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1
Orucevic, Fedja. « Production de microtores de silice sur silicium : excitation et caractérisation de leurs modes de galerie ». Paris 6, 2007. http://www.theses.fr/2007PA066642.
Texte intégralRésumé :
Les microtores de silice sur les puces de silicium sont un nouveau type de microcavités à modes de galerie. Dans la double filiation des microsphères de silice et des microdisques de GaAs, ils en combinent les avantages, soit la très haute surtension des cavités de silice fondue (Q ~ 107 – 109), et les faibles volumes accessibles par les microcavités intégrées (V~ 100*(lambda/N)3), ce qui fait d’eux des composants idéaux pour les expériences d’électrodynamique quantique en cavité et d’optique non-linéaire. L’intégration des microtores découle de leur méthode de fabrication qui implique successivement des étapes de la lithographie et gravure de la silice et du silicium, puis la fusion au laser CO2. Cette thèse décrit successivement les modes de galerie des microcavités toriques, et la méthode de fabrication des microtores. Elle porte ensuite sur la caractérisation, l’excitation et la détection de ces modes. Elle décrit notamment une détection en onde évanescente grâce à des fibres polies selon un plan formant un grand angle avec l’axe optique, en sorte de réaliser l’accord de phase entre la microcavité et la fibre. Ceci permet de sélectionner la fluorescence émise dans les modes de galerie, au détriment de la celle émises dans les modes fuyants. De meilleures sélectivité et efficacité sont obtenues en utilisant des fibres amincies (tapers) que nous avons produites et étudiés en grand détail. Ces résultats permettent d’obtenir un couplage optimal entre les tapers et les modes des microcavités. Le spectre des modes de galerie a ainsi pu être obtenu et comparé aux prédictions théoriques.
2
Lassalle, Emmanuel. « Emission quantique spontanée : modifications induites par l'environnement ». Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0197.
Texte intégralRésumé :
Le contrôle de l’émission spontanée d’émetteurs quantiques est d’une importance capitale dans le développement des futures technologies quantiques. La base de ces applications consiste en la manipulation d’atomes, de molécules ou d’atomes "artificiels", comme sources élémentaires de lumière, et en l’exploitation de la nature quantique de la lumière émise, constituée de photons uniques. En parallèle des développements récents des techniques de nanofabrication et des nanotechnologies, une compréhension théorique des mécanismes d’interaction fondamentaux entre émetteurs quantiques et leur environnement devient également capitale. Dans cette thèse, nous considérons l’émission spontanée dans trois paradigmes différents, traitant de la modification de ce processus due à l’environnement : le problème du "monitorage" de l’émission spontanée, l’interaction d’émetteurs quantiques avec des résonances optiques supportées par des structures nanométriques placées à proximité et l’interaction lointaine entre des émetteurs et des méta-surfaces. Nous présentons et utilisons différents formalismes pour modéliser ces différentes situations, qui interfacent différents domaines de la physique comme l’optique quantique et la nanophotonique. Nous illustrons chaque situation par des prédictions théoriques réalistes sur comment l’émission spontanée est modifiée. Pour chacune de ces prédictions, nous faisons des propositions expérimentales pour de futures confirmations de ces effets, afin d’améliorer notre compréhension et le contrôle de ces processus fondamentaux d’interaction lumière-matièreThe control of the spontaneous emission of quantum emitters is of fundamental importance for the development of future quantum technologies. Such applications rely on the manipulation of atoms, molecules, or "artificial" atoms, as elementary sources of light, and on the exploitation of the quantum nature of the emitted light, single photons. In parallel to the recent developments in nanofabrication techniques and nanotechnologies, theoretical understanding of the fundamental interaction mechanisms between quantum emitters and their environment also becomes more and more essential.In this thesis, we tackle three different paradigms of the spontaneous emission phenomenon, all dealing with modifications of the spontaneous emission induced the environment: the problem of monitored spontaneous emission, the interaction between quantum emitters and optical resonances supported by nearby nanostructures and the remote interaction between quantum emitters and metasurfaces. We present and deal with different formalisms to model such different situations, interfacing different fields of physics like quantum optics and nanophotonics. In each of these situations, we illustrate with realistic theoretical predictions how the spontaneous emission is modified. For each case, for provide with experimental proposals for future confirmations of these predictions, to bring a better understanding and control over these fundamental processes
3
FRANCESCHINI, PAOLO. « NOVEL SCHEMES FOR ULTRAFAST MANIPULATION OF QUANTUM MATERIALS ». Doctoral thesis, Università Cattolica del Sacro Cuore, 2022. http://hdl.handle.net/10280/111822.
Texte intégralRésumé :
La possibilità di controllare le proprietà elettroniche on-demand su una scala di tempo ultraveloce rappresenta una delle sfide più intriganti verso la realizzazione di dispositivi fotonici ed elettronici di nuova generazione. Stimolata da questo, negli ultimi decenni la ricerca scientifica ha concentrato la propria attenzione su diverse piattaforme a stato solido. Tra tutte, nanostrutture dielettriche (e metamateriali) e materiali correlati si presentano come i più promettenti candidati per la realizzazione di dispositivi dotati di nuove funzionalità. Al di là delle caratteristiche specifiche che rendono i dielettrici più adatti ad applicazioni in fotonica e i materiali correlati ai dispositivi elettronici, entrambe le categorie manifestano nuove funzionalità se soggetti ad uno stimolo esterno sotto forma di impulsi di luce con durata più breve della scala di tempo caratteristica del rilassamento dei gradi di libertà interni al sistema. Infatti, lo stato fuori equilibrio raggiunto a seguito di una foto-eccitazione presenta proprietà elettroniche ed ottiche di gran lunga differenti da quelle all'equilibrio. Pertanto, l'obiettivo di questo lavoro di tesi consiste nello sviluppo di nuovi metodi ed approcci sperimentali in grado di indurre, misurare e controllare nuove funzionalità in materiali complessi su una scala di tempo ultraveloce.The possibility to control the electronic properties on-demand on an ultrafast time scale represents one of the most exciting challenges towards the realization of new generation photonic and electronic devices. Triggered by this, in the last decades the research activity focused its attention to different solid-state platforms. Among all, dielectric nanostructures (and metamaterials) and correlated materials represent the most promising candidate for the implementation of devices endowed by new functionalities. Apart from the specific features making dielectrics more suitable for photonic applications and correlated materials for electronic devices, both categories exhibit new functionalities if subjected to an external stimulus in the form of excitation light pulses shorter than the relaxation timescale of the internal degrees of freedom of the system. Indeed, the out-of-equilibrium state achieved upon photoexcitation exhibits electronic and optical properties highly different from those at equilibrium. Therefore, the aim of this thesis work consists in the development of new methods and experimental approaches capable to induce, measure, and control new functionalities in complex materials on an ultrafast time scale.
4
NAHM, KIEBONG. « LIGHT SCATTERING BY POLYSTYRENE SPHERES ON A CONDUCTING PLANE (MIE, IMAGE CHARGE, INTERFERENCE, BRDF) ». Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188071.
Texte intégralRésumé :
A system consisting of a sphere sitting on a clean mirror was modeled as a two particle system: the real sphere and its image sphere, treating the mirror as a conducting plane. When the system was irradiated with a plane-polarized collimated laser beam with varying angles of incidence, the scattering from each particle was assumed to follow Mie's solution for light scattering by a sphere. Phase difference between the scattering by the real sphere and the one by its image sphere was assessed by the geometry of the model. The far field solutions from each of the spheres were added to yield a phase dependent intensity function. Another model assumed no phase correlation between the two and the intensities from each spheres were added. Also discussed is the Double Interaction Mode, which takes the mirror-sphere separation into consideration. These theoretical results were converted to Bidirectional Reflectance Distribution Functions (BRDF). The theoretical as well as the empirical surface scattering from a good quality optical surface was introduced. The BRDF values thus calculated were added to the background scattering by the mirror since no interaction was assumed between the spheres and the rough metallic surface of the mirror. The test sample was prepared with polystyrene spheres with the nominal diameter of 0.984 μm on a high quality aluminum mirror. The BRDF data from this sample with 6328Å and 4416Å were compared with the one obtained with the model described above. The comparison strongly indicated that there existed no phase correlation between the scatterings by the two spheres. Determination of the sphere size and practical applicability for estimating the sphere number density on the surface are also discussed.
5
Spiegel, Andrew William. « A Soft ECU Approach to Develop a Powertrain Control Strategy ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1430904023.
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6
So, Chi-leung. « Transgenic mouse model of human chondrodysplasia / ». Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19161347.
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Bishop, Katherine Mary. « A threshold model for development of the corpus callosum in normal and acallosal mice ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq22952.pdf.
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Wood, R. G. « Rossby waves in mid-latitude oceans ». Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379474.
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蘇志良 et Chi-leung So. « Transgenic mouse model of human chondrodysplasia ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31237678.
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衛永剛 et Wing-kong Wai. « Abnormal chondrocyte differentiation : a transgenic model ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237800.
Texte intégral
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Wai, Wing-kong. « Abnormal chondrocyte differentiation : a transgenic model / ». Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19656439.
Texte intégral
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Ho, Wing-lau, et 何穎流. « Investigating neurodegeneration in the retina of tau P301L mice ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B4833392X.
Texte intégralRésumé :
Neurodegeneration is a collective term for the progressive loss of structure, function or even death of neurons. This includes diseases like Alzheimer’s disease, frontotemporal dementia, Parkinson’s disease and motor neuron disease. Recent researches have shown great interest in the role of tau proteins, which have versatile functions including microtubule stabilization and signal relay in the central nervous system.
Retina and optic nerve, being part of the central nervous system, can also be affected by similar processes. In neurodegenerative diseases visual disturbances including difficulties in reading and finding object, depth perception, perceiving structure from motion, color recognition and impairment in spatial contrast sensitivity have all been observed. Some of these defects may be attributed to changes at ocular level.
The effect of tau mutation was investigated in this study utilizing a transgenic P301L tau mice model. Morphometric analysis has been utilized to quatify the neurodegenerative changes, including the thickness of inner nuclear layer(INL), density of retinal ganglion cells(RGCs) and size of RGCs. Retinal sections stained by hematoxylin and eosin(H&E) were analyzed. Comparisons were made between the P301L tau mice and the control mice in addition to comparisons between different age groups.
The study found that there was a significant decrease of thickness of INL of P301L tau mice when compared with control mice. The effect was more pronounced in the peripheral area and the effect increased with age. Regarding density of RGCs, P301L tau mice showed a similar age-related decline as control mice. And regarding the size of RGCs, the RGCs from P301L tau mice increased in size with age and the RGCs from control mice decreased in size with age.published_or_final_version
Anatomy
Master
Master of Medical Sciences
13
Bowling, John Robert Reid. « Design of an Experimental Mine Simulator for the Development of a Procedure for Utilization Multiple Tracer Gases in Underground Mines ». Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/32538.
Texte intégralRésumé :
An experimental mine simulator was constructed which will be used to conduct
tracer gas experiments in the laboratory. The test apparatus simulates a mine in a tabular
deposit and is modular and simple and can be easily rearranged to represent a variety of
mine geometries. The apparatus is appropriate for the use of tracer gases by being both
airtight and open-circuit (exhausting to the atmosphere) and by maintaining turbulent
flow throughout the model, ensuring the tracer gas is fully dispersed.
The model features ports for injection and sampling of tracer gases, which
represent boreholes present in an actual mine. The model is designed, in part, for the
practice of tracer gas release and sampling methods in the laboratory. Valves on the
apparatus represent ventilation controls, such as stoppings or regulators, or changing
resistances in a mine, such an increase in resistance due to a roof fall or a decrease in
resistance due to stoppings being destroyed. The relative resistances of airways can be
changed by changing the status of the valves to represent different states of the
ventilation controls.
The mine simulator should serve as a tool for identifying and investigating novel
tracer gases, developing a procedure for performing ventilation surveys using multiple
tracer gases, and eventually developing a method for remotely inferring ventilation
changes using tracer gases.Master of Science
14
Gilder, Michael Frederick James. « Molecular investigations in animal models of Huntington's disease ». Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325046.
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Liu, Chun. « Individual-based models of wood mice in ecotoxicology ». Thesis, University of Reading, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590671.
Texte intégralRésumé :
The wood mouse (Apodemus sylvaticus) is a common and widespread species in Europe and therefore often used as a focal species in the risk assessments of pesticides. Recent years have seen a growing interest in the use of ecological models in ecological risk assessments. The purpose of this PhD project was to construct and apply population models of the wood mouse to support risk assessment of pesticides. In the thesis I first reviewed the current practice of risk assessment and the weaknesses and the advantages of ecological models, in particular individual-based models. Following a modelling cycle, the PhD project started with a literature review of the basic ecology of the wood mouse and relevant information for modelling purposes. A conceptual model was then constructed, based on which an individual-based model was developed. The model was fully described and its ecological credibility was evaluated by the "pattern-oriented" validation method. The model was then used to link the spatial choice of wood mice and their potential exposure to pesticide application in the field. Analyses of the model showed that when the population density reached a high level in the off-crop hedgerows, which act as the source habitat for wood mice, the surplus were driven to the crop fields and thus have a high risk of exposure if pesticides are applied. The model was further developed by incorporating a sub module of toxicokinetic processes which represented exposure as internal concentration instead of ingested dose. The interactions between the spatial patterns of foraging provided by the individual-based model and the temporal patterns of absorption and elimination provided by the toxicokinetic model were explored. The combined model showed little further reduction of risk than either of the two models respectively alone. It suggested that such a combined approach is most likely to bring added value when the spatio-temporal patterns of feeding are at the intermediate level, i.e. when mice divide their foraging between exposed crop and unexposed areas. I then used the model to explore the population-level sensitivity in terms of both population size and population growth rate, to detrimental effects on individual-level life-history traits. The results showed the two indices had different sensitivities to changes in life-history traits. Thus, endpoint from the models used in risk assessments should take into account whether the protection goal is to ensure that the population remains stable or that it grows. The overall high level of sensitivity to survival also indicated that protection should be more focused on acute effects than chronic effects. Finally I summarised the major findings in the thesis and discussed the need for future research, as well as the lessons learnt about conventional risk assessment approach and the opportunities ecological modelling brings for a more realistic and ecologically relevant risk assessment for pesticides.
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Islam, Aunul. « Catalytic hydrogenation of model coal extract mid-distillates ». Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38048.
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Wang, YueYi. « Ca2+ handling in a mice model of CPVT ». Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS156/document.
Texte intégralRésumé :
Le canal calcique de libération du Ca2+, appelé récepteur à la ryanodine (RyR) est localisé dans la membrane du réticulum sarcoplasmique des cardiomyocytes, en incluant ceux du pacemaker, et a un rôle important dans le couplage excitation contraction et la génération du rythme cardiaque. Des mutations dans leur gène sont responsables de la tachycardie catécholergique (CPVT), qui est une maladie létale, manifestée par des syncopes ou mort subite lors de stress émotionnel ou physique. Au repos, ces patients ont un électrocardiogramme normal, mais une tendance plus importante à la bradycardie.Nos collaborateurs ont identifié la mutation RyR2R420Q dans une famille espagnole atteinte de CPVT. Nous avons construit une souris portant cette mutation et étudié l’activité du nœud sinoatrial (NSA, pacemaker principale) afin d’élucider les mécanismes.Nous avons trouvé que les cellules du NSA présentent une activité spontanée plus lente que les souris sauvages (WT). Dans la cellule in situ, on peut étudier l’activité des RyRs par l’analyse des « sparks » Ca2+, qui sont des évenements élémentaires produits par l’activation d’un cluster des RyRs. Nos analyses en microscopie confocale sur des NSA disséquées on montré que la fréquence des sparks Ca2+ était légèrement augmentée. Par contre, la longueur de ces sparks est fortement prolongée dans les cellules KI. Ceci produit une libération plus importante de Ca2+ pendant la diastole dans les cellules KI qui réduit l’automatisme, en réduisant la charge en Ca2+ du réticulum sarcoplasmique et en inactivant le courant calcique type L. Donc les thérapies en étude qi favoriseraient la stabilisation du RyR2 en état fermé pourraient ne pas Être efficaces, et il faudra plutôt essayer des thérapies qui faciliteraient la fermeture du canal, une fois il est ouvertThe cardiac type-2 ryanodine receptor (RyR2) encodes a Ca2+ release channel on sarcoplasmic reticulum (SR) membrane in cardiomyocytes, including sinoatrial node (SAN) myocytes, and releases Ca2+ required for contraction and SAN spontaneous rhythm. Its genetic defects are related to catecholaminergic polymorphic ventricular tachycardia (CPVT), which is a lethal heritable disease characterized by exercise/stress-induced syncope and/or sudden cardiac death. Interestingly, CPVT patients frequently present SAN dysfunction as bradycardia at rest.In a previous study, a novel CPVT-related RyR2 mutation (RyR2R420Q) in a Spanish family, associated with SAN dysfunction was reported. R420 is located at the N-terminal portion of the channel and seems to be an important site for maintaining a stable A/B/C domain of N-terminus in RyR2. As N-terminal mutation resultant RyR2 behaviour and SAN function are never analyzed before, we created the KI mice model bearing mutation R420Q to understand the underlying mechanism.In this thesis, we found increased Ca2+ release during diastole, indicating a gain-of-function effect of RyR2 N-terminal mutation R420Q. Interestingly, this defect may not be only an enhanced activity, as the Ca2+ sparks frequency was only slightly increased in KI, but also the closing mechanism, producing longer Ca2+ sparks. That is, the number of Ca2+ sparks is increased by the RyR2R420Q mutation, and meanwhile the amount of Ca2+ released in each Ca2+ spark is also dramatically enhanced. This increased Ca2+ release retards SR Ca2+ replenishment, disrupting the Ca2+ clock and the coupled clock, resulting in the slower SAN function. Thus favouring RyR stabilization in the closing state might not be an adequate therapy but accelerating its closure
18
Bucaioni, Alessio. « Bidirectionality in Model-Driven Engineering ». Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-18202.
Texte intégralRésumé :
In Model-Driven Engineering bidirectional model transformations emerged as an important ingredient to cope with scenarios such as change propagation, synchronization and to keep consistent system views whenever changes occurring on some view have to be propagated over the others. However, bidirectional mappings open a number of intricate issues that have been only partially solved by research. This master thesis identifies a set of features characterizing bidirectional transformations and validates them against two existing approaches. In particular, a benchmark based on the UML2RDBMS transformation and consisting of two different configurations is implemented by means of two different approaches, such as Triple Graph Grammars and the Janus Transformation Language, for understanding bidirectional transformations with respect to the elicited features.
19
Siu, Kwan-yin. « The development and characterization of a knockout model for secretin ». Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40887674.
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Clifford, Adrianne Brown. « Tumor Associated Macrophages in a MaFIA Mouse Model ». Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1427.pdf.
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Rezazadeh, Baee Mir Ali. « Privacy-preserving authentication and key management for cooperative intelligent transportation systems ». Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212412/1/Mir%20Ali_Rezazadeh%20Baee_Thesis.pdf.
Texte intégralRésumé :
Car accidents kill or injure millions of people. Cooperative Intelligent Transportation Systems (C-ITS) can increase road safety and reduce accidents through the application of information and communication technologies for communicating vehicles. However, C-ITS applications are vulnerable to potential cyber-attacks involving message manipulation, where messages may be altered intentionally or fake messages sent, compromising the safety goals. Cryptographic techniques can be used to solve this, but this must be done in a way that preserves driver privacy, so that unauthorized surveillance and tracking of drivers is not possible. This research develops a secure conditional privacy-preserving authentication scheme for C-ITS applications.
22
Huang, Mei-hui. « Factors influencing self-directed learning readiness amongst Taiwanese nursing students ». Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/20709/1/Mei-hui_Huang_Thesis.pdf.
Texte intégralRésumé :
Rapid scientific and technological advances in health care mean that nurses need to keep learning and engage in professional education so that they can continue to provide safe and quality care. Education programs which prepare nurses for practice as a registered nurse have a vital role to play in ensuring that graduates are self-directed in responding to the need for ongoing learning throughout their professional career. In many countries, improving students’ readiness for self-directed learning has thus gained increasing recognition as being an important goal of nursing education programs. This level of interest in developing self-directedness in learning is evident in many policy documents and research in Taiwan. The aim of this study was to investigate factors influencing self-directed learning readiness amongst Taiwanese nursing students. A conceptual framework adopted from Biggs’s ‘3P model of teaching and learning’ was constructed to guide this study’s investigation. This study employed a two-staged mixed-method design to obtain a better understanding of Taiwanese students’ experience of SDL in undergraduate nursing programs. Stage one of the present study was a qualitative approach using semi-structured interview to explore students’ experiences with learning activities which they perceived to be self-directed in their undergraduate programs. Eight students were interviewed. Findings from this stage reveal that participants perceived a shift in teaching and learning styles between their previous nursing programs and the university. The more frequent use of student-directed learning activities, in which students were encouraged to be active and to take responsibility for their learning tasks, was one of the changes in teaching and learning approaches perceived by participants. Participants further suggested a number of factors that influenced the outcomes of these learning activities, including teacher-student interaction, facilitation process and learning resources. Stage two of this study used a quantitative approach consisting of two phases: instrument pilot testing and a cross-sectional survey. In the first phase, the instruments were translated into Chinese through a rigorous translation process and tested with a convenience sample of nursing students in Taiwan. Results indicated the translated instruments were reliable and stable. The second phase, a cross-sectional survey, was conducted to examine the conceptual framework of this study. A total of 369 undergraduate nursing students completed the questionnaire. Results of data analysis provides support for the conceptual framework proposed for this study, suggesting that students’ achievement goals and their perceptions of the learning environment significantly influence their adoption of learning approaches and the development of SDL readiness. Based on the results, this study provides practical implications that nurse educators may adopt to enhance students’ SDL readiness. This study also provides theoretical implications and recommendations for future research. It is envisaged that these recommendations may help future researchers focus their research design and further understandings of how to help students develop their ability to become self-directed learners.
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Thomas, Sunu Samuel. « Murine models of cerebral ischemia, development of a mouse model of global cerebral ischemia ; response of GluR2 knockout mice in a model of permanent focal cerebral ischemia ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0026/MQ50439.pdf.
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Maheu, Bruno. « Généralisation de la théorie de Lorenz-Mie et applications ». Rouen, 1987. http://www.theses.fr/1987ROUES025.
Texte intégralRésumé :
Théorie de la diffusion d'un faisceau gaussien par un diffuseur sphérique homogène et isotrope. Les résultats ouvrent sur des applications à la granulométrie optique. On expose par la suite un modèle à quatre flux pour décrire la diffusion multiple d'une onde électromagnétique par un nuage dense de diffuseurs
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Hebig, Regina, et Holger Giese. « MDE settings in SAP : a descriptive field study ». Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2012/6019/.
Texte intégralRésumé :
MDE techniques are more and more used in praxis. However, there is currently a lack of detailed reports about how different MDE techniques are integrated into the development and combined with each other. To learn more about such MDE settings, we performed a descriptive and exploratory field study with SAP, which is a worldwide operating company with around 50.000 employees and builds enterprise software applications. This technical report describes insights we got during this study. For example, we identified that MDE settings are subject to evolution. Finally, this report outlines directions for future research to provide practical advises for the application of MDE settings.Techniken der modellgetriebenen Entwicklung (MDE) werden mehr und mehr in der Praxis eingesetzt. Dabei gibt es wenige detaillierte Berichte darüber wie unterschiedliche MDE-Techniken kombiniert und in die Entwicklung integriert werden. Die vorliegende beschreibende Feldstudie dient dem Zweck, in SAP genutzte MDE-Ansätze detailliert zu beschreiben. SAP ist ein weltweit operierendes Unternehmen, hat ca. 50 000 Mitarbeiter und stellt Softwarelösungen für Firmen her. Der vorliegende technische Bericht beschreibt die Einblicke die wir in dieser Studie erhalten haben. Dazu gehört die Einsicht, dass MDE Ansätze einer Evolution unterliegen. Schließlich umreißt dieser Bericht mögliche Richtungen für zukünftige Forschung um praktische Ratschläge für die Gestaltung von MDE Ansätzen geben zu können.
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Meehan, Patrick James. « Development of a Water Cloud Radiance Model for Use in Training an Artificial Neural Network to Recover Cloud Properties from Sun Photometer Observations ». Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/103742.
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As the planetary climate continues to evolve, it is important to build an accurate long-term climate record. State-of-the-art atmospheric science requires a variety of approaches to the measurement of the atmospheric structure and composition. This thesis supports the possibility of inferring cloud properties from sun photometer observations of the cloud solar aureole using an artificial neural network (ANN). Training of an ANN requires a large number of input and output parameter sets. A cloud radiance model is derived that takes into consideration the cloud depth, the mean size of the cloud water particles, and the cloud liquid water content. The cloud radiance model derived here is capable of considering the wavelength of the incident sunlight and the cloud lateral dimensions as parameters; however, here we consider only one wavelength—550 nm—and one lateral dimension—500 m—to demonstrate its performance. The cloud radiance model is then used to generate solar aureole profiles corresponding to the cloud parameters as they would be observed using a sun photometer. Coefficients representative of the solar aureole profiles may then be used as inputs to a trained ANN to infer the parameters used to generate the profile. This process is demonstrated through examples. A manuscript submitted for possible publication based on an early version of the cloud radiance model was deemed naïve by reviewers, ultimately leading to improvements documented here.Master of Science
The Earth's climate is driven by heat from the sun and the exchange of heat between the Earth and space. The role of clouds is paramount in this process. One aspect of "cloud forcing" is cloud structure and composition. Required measures may be obtained by satellite or surface-based observations. Described here is the creation of a numerical model that calculates the disposition of individual bundles of light within water clouds. The clouds created in the model are all described by the mean size of the cloud water droplets, the amount of water in the cloud, and cloud depth. Changing these factors relative to each other changes the amount of light that traverses the cloud and the angle at which the individual bundles of light leave the cloud as measured using a device called a sun photometer. The measured amount and angle of bundles of light leaving the cloud are used to recover the parameters that characterize the cloud; i.e., the size of the cloud water droplets, the amount of water in the cloud, and the cloud depth. Two versions of the cloud radiance model are described.
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Agarwal, Rajat. « A model for minimizing cost for housing laboratory mice ». [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0001241.
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Balastik, Martin. « Trim2 mutant mice as a model for cerebellar ataxia ». Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=975117025.
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Kowalski, P. C. « Models of interannual mid-latitude sea surface temperature variability ». Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1394920/.
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Well established and novel simple mixed layer models are used to investigate some of the factors influencing mid-latitude sea surface temperature variability. This thesis focuses in particular on the re-emergence mechanism and the factors that influence it. The re-emergence mechanism describes the process whereby winter sea surface temperature anomalies can become sequestered below the mixed layer as it reforms in the spring/summer and are entrained into the mixed layer in the following winter, subsequently impacting the sea surface temperature. In chapter 2 the idealized mixed layer column model used in Stevenson [36] and the quasi-geostrophic wind driven ocean model are derived. Chapter 3 investigates how sea surface temperature anomalies are generated and decay through mixed layer processes and in the absence of atmospheric feedback. The e ect of atmospheric feedback on the sea surface temperature and mixed layer is investigated in chapter 4. Two new models of the re-emergence mechanism are presented in chapter 5: the first is a stochastic two season model and the second is an entraining mixed layer model with a fixed mixed layer annual cycle. These models are used to investigate some of the factors, such as the diff erence between the summer and winter mixed layer depth, that influence the re-emergence mechanism. The impact of interannual mixed layer depth variability on the re-emergence mechanism is then investigated using the model of Stevenson [36]. In chapters 6 and 7, the impact of local Ekman pumping and associated Rossby wave induced vertical motion on the sea surface temperature, the mixed layer and the re-emergence mechanism are investigated.
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Siu, Kwan-yin, et 蕭君言. « The development and characterization of a knockout model for secretin ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40887674.
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Owen, Michelle L. « Exposure model : detailed profiling and quantification of the exposure of personnel to geotechnical hazards in underground mines ». University of Western Australia. School of Civil and Resource Engineering, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0031.
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[Truncated abstract] This thesis presents an operationally applicable and reliable model for quantification of the exposure of underground mining personnel to geotechnical hazards. The model is shown to have the flexibility to apply to very different operational environments, within the context of mechanised metalliferous mines. It provides an essential component for carrying out quantitative geotechnical risk analyses of underground mines. Increasingly prevalent within the Australian mining industry are moves towards a riskbased philosophy instead of prescriptive design procedures. A barrier to this has been the lag in availability of resources (personnel and technical) required for the intensive effort of applying probabilistic methods to geotechnical engineering at mines ... One of the missing components for quantitative risk analysis in mines has been an accurate model of personnel exposure to geotechnical hazards, from which meaningful estimates can be made of the probabilities of serious or fatal injury given a rockfall. Exposure profiling for geotechnical risk analysis at minesites has traditionally involved the simple classification of travelways and entry areas by their occupancy rate, not taking into account traffic and work characteristics which may significantly influence the risks. Therefore, it was the focus of this thesis to address that deficiency and progress the ability to perform semi-quantitative and quantitative risk analyses in mines.
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Arbic, Brian K. « Generation of mid-ocean eddies : the local baroclinic instability hypothesis ». Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/53047.
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Thesis (Ph.D.)--Joint Program in Physical Oceanography (Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences and the Woods Hole Oceanographic Institution), 2000.Includes bibliographical references (p. 284-290).
by Brian Kenneth Arbic.
Ph.D.
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Reed, J. « Mine roadway modelling methods ». Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383759.
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Chung, Chi-kin Samuel. « The development and characterization of a gene-knockout mouse model for secretin receptor / ». View the Table of Contents & ; Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31491121.
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Ganesan, Poo Balan. « Development of an image-based anatomical network model and modelling of circulation of mouse retinal vasculature ». Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210068.
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Eastgard, Rebecca Lugar. « Diet-induced hyperhomocysteinemia in a mouse model / ». Thesis, Connect to this title online ; UW restricted, 2002. http://hdl.handle.net/1773/6601.
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Planckaert, Jean-Pierre. « Modélisation du soudage MIG/MAG en mode short-arc ». Phd thesis, Université Henri Poincaré - Nancy I, 2008. http://tel.archives-ouvertes.fr/tel-00325823.
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Il existe aujourd'hui de nombreux procédés de soudage répondant à la très grande variété d'assemblage à réaliser et aux caractéristiques des métaux utilisés. Le premier chapitre décrit les différentes sources d'énergie utilisées en soudage. Suite à cela, une explication plus détaillée du soudage à l'arc électrique est donnée. Enfin nous présentons la conception d'une plateforme d'essai de soudage.Il est possible, bien sûr, d'utiliser une approche empirique pour optimiser un procédé. Néanmoins il y a des avantages à choisir une approche analytique puisqu'on peut en attendre des avancées significatives dans la compréhension des interactions dynamiques présentes dans l'arc. C'est pourquoi nous présentons dans le chapitre 2 les connaissances théoriques de la physique quant au comportement du métal liquide transféré en soudage MIG/MAG.
Ce travail comporte donc également un aspect expérimental nécessaire à l'élaboration des bases de données utilisées pour la construction des modèles. Les différents enregistrements ont été effectués au CTAS sur une plate forme équipée d'un système d'acquisition de données pour les mesures de tension, courant, vitesse fil et d'un système de vidéo rapide. Le chapitre 3 présente notre recherche d'une méthode de segmentation permettant d'obtenir le suivi de variables pertinentes. Nous y proposons un capteur logiciel basé sur la théorie des contours actifs et montrons de bons résultats obtenus sur des vidéos expérimentales.
Une étape d'ajustement de certains paramètres est indispensable. Elle est donnée dans le chapitre 4. Le simulateur créé permet d'interpréter certains phénomènes importants en soudage, de réaliser une étude de sensibilité « sans risque » et de donner les signatures théoriques de défauts.
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Liljestrand, Charlotte. « Spatial mode engineering in mid-infrared optical parametric oscillators ». Thesis, KTH, Laserfysik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-42705.
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The purpose of this thesis was to investigate the possibilities of enhancing the temporal and spatial coherence of parametric devices in the mid-infrared spectrum by exploiting inherent coherence selection of Bessel beams. Several optical parametric oscillators (OPO) were constructed and characterized for various types of resonators and pump lasers. In the first part of this work an OPO was constructed out of a periodically poled KTP (PPKTP) crystal within a stable resonator. It was pumped by a Q-switched Nd:YAG laser in transversal and longitudinal single mode operation. The OPO was pumped at 1064 nm and operated at signal wavelength of 1595.9 nm with a bandwidth at FWHM of 0.2 nm and idler wavelength 3192.9 nm and bandwidth of 0.5nm at FWHM. The stable resonator was constructed out of a curved input coupler and a planar output coupler to generate a spatially coherent beam. The beam quality factor of the OPO was measured to M2=1.3 and M2=1.7 in the horizontal and the vertical direction respectively. In the second part of this work conical beams, and hence noncollinear phase matching, was used. This was done to improve and study the temporal and spatial coherence of the generated beam if the OPO is pumped by a laser operating in multiple transversal and longitudinal modes. Using noncollinear phase matching provides a possibility of generating a highly coherent signal (or idler) wave when using a pump laser which operates in multiple transversal and longitudinal modes. Usually, such pump laser makes it difficult to generate highly coherent beams since the properties, such as bandwidth and beam quality factor, of the pump laser are transferred to the generated waves. So called multimode lasers, which operate in multiple modes, can be considered inexpensive and reliable while providing high pulse energies, and they are therefore attractive as pump sources for nonlinear processes. Throughout this second part a Q-switched Nd:YAG laser operating in multiple transversal and longitudinal modes at a wavelength 1064 nm was used. Optical parametric generation (OPG) was used to compare the effects between pumping with a Gaussian wave, and collinear phase matching, and pumping with a conical, a Bessel beam and hence noncollinear phase matching. Thereafter, optical parametric oscillation was studied with collinear and noncollinear phase matching using a Fabry-Perot cavity. The OPO pumped by a Q-switched Gaussian beam, and hence using collinear phase matching had a signal wave at 1596.3 nm and a bandwidth at FWHM of 4 nm. The OPO pumped by a conical beam, hence a Bessel beam and noncollinear phase matching, had a signal wave at 1596.5 nm and a bandwidth at FWHM of 0.2 nm. Both OPOs had a beam quality factor M2~2 in horizontal and vertical direction.
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Planckaert, Jean-Pierre Brie David Djermoune El-Hadi. « Modélisation du soudage MIG/MAG en mode short-arc ». S. l. : Nancy 1, 2008. http://www.scd.uhp-nancy.fr/docnum/SCD_T_2008_0024_PLANCKAERT.pdf.
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Zhu, Gongwen. « Q-switched and Mode-locked Mid-IR Fiber Lasers ». Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/578593.
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Mid-infrared (IR) lasers (2-12 μm) have found tremendous applications in medical surgeries, spectroscopy, remote sensing, etc. Nowadays, mid-IR emissions are usually generated from semiconductor lasers, gas lasers, and solid-state lasers based on nonlinear wavelength conversion. However, they usually have disadvantages including poor beam quality, low efficiency, and complicated configurations. Mid-IR fiber lasers have the advantages of excellent beam quality, high efficiency, inherent simplicity, compactness, and outstanding heat-dissipating capability, and have attracted significant interest in recent years. In this dissertation, I have studied and investigated Q-switched and mode-locked fiber lasers in the mid-IR wavelength region. My dissertation includes six chapters: In Chapter 1, I review the background of mid-IR lasers and address my motivation on the research of mid-IR fiber lasers; In Chapter 2, I present the experimental results of microsecond and nanosecond Er³⁺-doped and Ho³⁺-doped fiber lasers in the 3 μm wavelength region Q-switched by Fe²⁺:ZnSe and graphene saturable absorbers. In Chapter 3, Q-switched 3 μm laser fiber amplifiers are investigated experimentally and theoretically and their power scaling are discussed. In Chapter 4, a graphene mode-locked Er³⁺-doped fiber lasers at 2.8 μm with a pulse width < 50 ps is presented. In Chapter 5, extending the spectral range of mid-IR fiber lasers by use of nonlinear wavelength conversion is addressed and discussed. I have proposed 10-watt-level 3-5 μm Raman lasers using tellurite fibers as the nonlinear gain medium and pumped by our Er³⁺-doped fiber lasers at 2.8 μm. In the last chapter, the prospect of mid-IR fiber laser is addressed and further research work is discussed.
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Cook, Amy. « Development of an Integrated Surface and Subsurface Model of Everglades National Park ». FIU Digital Commons, 2012. http://digitalcommons.fiu.edu/etd/634.
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An integrated surface-subsurface hydrological model of Everglades National Park (ENP) was developed using MIKE SHE and MIKE 11 modeling software. The model has a resolution of 400 meters, covers approximately 1050 square miles of ENP, includes 110 miles of drainage canals with a variety of hydraulic structures, and processes hydrological information, such as evapotranspiration, precipitation, groundwater levels, canal discharges and levels, and operational schedules. Calibration was based on time series and probability of exceedance for water levels and discharges in the years 1987 through 1997. Model verification was then completed for the period of 1998 through 2005. Parameter sensitivity in uncertainty analysis showed that the model was most sensitive to the hydraulic conductivity of the regional Surficial Aquifer System, the Manning's roughness coefficient, and the leakage coefficient, which defines the canal-subsurface interaction. The model offers an enhanced predictive capability, compared to other models currently available, to simulate the flow regime in ENP and to forecast the impact of topography, water flows, and modifying operation schedules.
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Marx, Carl. « An analytical accident investigation model for the South African mining industry ». Thesis, University of Pretoria, 2003. http://hdl.handle.net/2263/25826.
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Ou, Linda Ye. « Hyperactive p53 leads to age-related phenotypes in mice model ». Diss., [La Jolla, Calif.] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p1460672.
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Heess, Nicolas Manfred Otto. « Learning generative models of mid-level structure in natural images ». Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/5866.
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Natural images arise from complicated processes involving many factors of variation. They reflect the wealth of shapes and appearances of objects in our three-dimensional world, but they are also affected by factors such as distortions due to perspective, occlusions, and illumination, giving rise to structure with regularities at many different levels. Prior knowledge about these regularities and suitable representations that allow efficient reasoning about the properties of a visual scene are important for many image processing and computer vision tasks. This thesis focuses on models of image structure at intermediate levels of complexity as required, for instance, for image inpainting or segmentation. It aims at developing generative, probabilistic models of this kind of structure, and, in particular, at devising strategies for learning such models in a largely unsupervised manner from data. One hallmark of natural images is that they can often be decomposed into regions with very different visual characteristics. The main approach of this thesis is therefore to represent images in terms of regions that are characterized by their shapes and appearances, and an image is then composed from many such regions. We explore approaches to learn about the appearance of regions, to learn about region shapes, and ways to combine several regions to form a full image. To achieve this goal, we make use of some ideas for unsupervised learning developed in the literature on models of low-level image structure and in the “deep learning” literature. These models are used as building blocks of more structured model formulations that incorporate additional prior knowledge of how images are formed. The thesis makes the following contributions: Firstly, we investigate a popular, MRF based prior of natural image structure, the Field-of Experts, with respect to its ability to model image textures, and propose an extended formulation that is considerably more successful at this task. This formulation gives rise to a fully parametric, translation-invariant probabilistic generative model of image textures. We illustrate how this model can be used as a component of a more comprehensive model of images comprising multiple textured regions. Secondly, we develop a model of region shape. This work is an extension of the “Masked Restricted Boltzmann Machine” proposed by Le Roux et al. (2011) and it allows explicit reasoning about the independent shapes and relative depths of occluding objects. We develop an inference and unsupervised learning scheme and demonstrate how this shape model, in combination with the masked RBM gives rise to a good model of natural image patches. Finally, we demonstrate how this model of region shape can be extended to model shapes in large images. The result is a generative model of large images which are formed by composition from many small, partially overlapping and occluding objects.
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Neves, Maria C. « Models of stress at mid-ocean ridges and their offsets ». Thesis, Durham University, 2000. http://etheses.dur.ac.uk/4408/.
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This thesis aims to investigate the stresses at mid-ocean ridge offsets, and particularly at the particular class of offsets represented by oceanic microplates. Amongthese, the Easter microplate is one of the best surveyed. This thesis first studies the stress field associated with mid-ocean ridges and simple types of ridge offsets, and then uses the stress field observed at Easter to constrain the driving mechanism of microplates. Two-dimensional finite element modelling is used to predict the lithospheric stress indicators, which are then compared with observations. Extensional structures at high angles (> 35 ) to ridge trends are often observed at ridge-transform intersections and non-tranform offsets, but remained unexplained until now. This study proposes that the topographic loading created by the elevation of mid-ocean ridges relative to old seafloor is a source of ridge parallel tensile stresses, and shows they can be explained by the rotation of ridge parallel tensile stresses at locked offsets. The elasto-plastic rheology is used to investigate the evolution of normal faults near mid-ocean ridges. It is shown that variations in the lithospheric strength, caused entirely by variations in the brittle layer thickness, can account for the observed variations in fault character with spreading rate and along-axis position. Plasticity is shown to prevent the achievement of large fault throws in thin brittle layers. Consequently, it may be important at fast spreading ridges. A new dynamic model is proposed for Easter microplate. It mainly consists of: 1) driving forces along the East and West Rifts, resulting from the combination of a regional tensile stress with an increasing ridge strength towards rift tips, 2) mantle basal drag resisting the microplate rotation, and contributing with less than 20% to the total resisting torque, and 3) resisting forces along the northern and southern boundaries. To explain both the earthquake focal mechanism evidence and theexistence of compressional ridges in the Nazca plate, the boundary conditions alongthe northern boundary are required to change with time, from completely locked tolocked in the normal direction only. This study does not invalidate the microplate kinematic model proposed by Schouten et al. (1993), but shows that normal resisting forces along the northern and southern boundaries of Easter microplate must exist in order to explain the stress observations. Also, it suggests that ridge strength variations play an important role in the dyamics of mid-ocean ridge overlap regions.
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Scott, Jameson Lee. « Towards a Petrologically Constrained Thermal Model of Mid-Ocean Ridges ». The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1496397674423802.
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Makinen, Kimmo. « Spontaneous model of experimental autoimmune uveoretinitis : IRBP-HEL transgenic mice ». Thesis, University of Aberdeen, 2006. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU490269.
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To generate a spontaneous EAU model, transgenic mice expressing membrane-bound hen egg lysozyme (HEL) under control of the IRBP promoter were generated. The mice expressed HEL in the photoreceptors, and in the thymus as measured by immunofluorescent confocal microscopy and real-time RT-PCR, respectively. When crossed with the 3A9 TCR-transgenic mice whose CD4+ T cells are HEL-specific, double-transgenic mice developed spontaneous EAU with 100% incidence and an onset age of 22 days post-partum. The ocular inflammation was multifocal and affected the posterior segment of the eye, and led to complete retinal destruction over 5-8 weeks. The lesions comprised multiple retinal granulomas, vasculitis, perivasculitis, mild vitritis and infiltration at the limbus (junction between cornea and sclera). The retina contained numerous CD4+T cells, which made contact with perivascular MHC II+CD11c+ dendritic cells, whilst F4/80 + macrophages were found within the photoreceptor cell layer, implicating them in structural damage. Therefore, the features of spontaneous EAU resembled those of IRBP-induced EAU. One difference, however, was that there were many CD3+CD4-gammadelta-like T cell cells in the inflamed retina, which were also the earliest T cells to enter the eye at EAU onset. CD4SP thymocytes were severely deleted in the double-tg mice, leading to peripheral CD4+ T cell deficiency at EAU onset, which bestowed a CD44hi pseudomemory phenotype on clonotype low CD4+T cells, and may have enabled breakdown of tolerance. The early activation marker CD69 was not upregulated on CD4+ T cells in any of the secondary lymphoid tissues studied, suggesting that HEL presentation may have been exclusive to the eye. The IRBP-HEL mice also constitute a new EAU model system in which self-tolerance and the efficacy of therapeutics can be studied.
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Nguyen, Tam Hong. « Pex13 Mutant Mice as Models for the Peroxisome Biogenesis Disorders ». Thesis, Griffith University, 2008. http://hdl.handle.net/10072/366797.
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Zellweger syndrome (ZS) is the most severe form of a spectrum of disorders resulting from mutations in PEX genes, genes that encode proteins necessary for peroxisome biogenesis. Loss of functional peroxiosmes leads to disruption of multiple metabolic pathways involving the peroxisome, including very long chain fatty acid oxidation and plasmalogen and bile acid synthesis. ZS patients exhibit a range of clinical abnormalities, including facial dysmorphism, cataracts, hypotonia, seizures, psychomotor retardation, and hearing impairment. In terms of tissue pathology, there are also wide ranging effects, including neuronal migration defects, hepatomegaly, retinopathy, and renal cysts. Pex13 encodes a peroxisomal membrane protein that is essential for peroxisome biogenesis. Previous work in this laboratory resulted in the generation of a Pex13-null mouse model for the purpose of investigating the pathogenesis of Zellweger syndrome. The work in the first part of this thesis extends these studies and describes the generation and initial characterisation of tissue-specific Pex13 mouse models. These tissue-specific models are expected be useful tools for analysis of the impact of localised, brain- and liver-specific elimination of peroxisomes on the pathogenesis of ZS. In addition, in the second part of the thesis, a separate and novel hypothesis is addressed as an explanation for the molecular pathogenesis of ZS, through investigating the relationship between reduced peroxisome abundance and microtubule-mediated peroxisome trafficking.
Pex13 brain mutant mice were generated by mating the previously generated Pex13-floxed mice with mice expressing Cre recombinase under the control of the neuron-specific rat nestin promoter. Pex13 brain mutant mice displayed growth retardation beginning at day 5 postnatal, with gradual deterioration until death at approximately day 22 postnatal. Other clinical features included contracted postures, under-developed lower body mass, abnormal and unsteady gait, and abnormal motor coordination. In terms of brain metabolic function, these mice exhibited significant defects in plasmalogen synthesis, but, surprisingly, VLCFA levels were similar to those of littermate control mice. Significantly, peroxisome elimination in brain resulted in increased levels of plasmalogen levels in liver of Pex13 brain mutant mice. Consistent with the expected pathology resulting from deficiency of brain peroxisomes, brain mutants exhibited defective neuronal migration characterised by increased cellular density in the intermediate zone of the neocortex. Microarray analysis of total brain RNA from Pex13 brain mutants revealed several functionally-linked pathways associated with the differentially expressed genes, including cell-cell signalling, cell compromise/death, lipid metabolism, cell movement, and serotonin synthesis.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
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陳醒覺 et Sing-kwok Chan. « Mouse preproendothelin-1 gene : transgenic mouse models to study tissue-specific and developmental expression andregulation ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31236571.
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Stinnett, Hilary M. « OSTEOACTIVIN IN SKELETON : CHARACTERIZATION OF OSTEOACTIVIN KNOCKOUT MICE & ; THERAPEUTIC IMPLICATIONS ». Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1428859108.
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