Littérature scientifique sur le sujet « Microproteins »
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Articles de revues sur le sujet "Microproteins"
Bhati, Kaushal Kumar, Valdeko Kruusvee, Daniel Straub, Anil Kumar Nalini Chandran, Ki-Hong Jung et Stephan Wenkel. « Global Analysis of Cereal microProteins Suggests Diverse Roles in Crop Development and Environmental Adaptation ». G3: ; Genes|Genomes|Genetics 10, no 10 (6 août 2020) : 3709–17. http://dx.doi.org/10.1534/g3.120.400794.
Texte intégralMartinez, Marion, Marta Hergueta, Pilar Ximénez de Embún, Ana Dueso, David Torrents, Teresa Macarulla, Javier Muñoz, Héctor Peinado et María Abad. « Abstract C074 : Mining the secreted microproteome for novel regulators of PDAC progression ». Cancer Research 82, no 22_Supplement (15 novembre 2022) : C074. http://dx.doi.org/10.1158/1538-7445.panca22-c074.
Texte intégralKumagai, Hiroshi, Brendan Miller, Su-Jeong Kim, Naphada Leelaprachakul, Naoki Kikuchi, Kelvin Yen et Pinchas Cohen. « Novel Insights into Mitochondrial DNA : Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases ». Genes 14, no 2 (21 janvier 2023) : 286. http://dx.doi.org/10.3390/genes14020286.
Texte intégralCelia Henry Arnaud, special to C&EN. « Microproteins, macro impact ». C&EN Global Enterprise 101, no 19 (12 juin 2023) : 13–15. http://dx.doi.org/10.1021/cen-10119-feature1.
Texte intégralChen, Jin, Andreas-David Brunner, J. Zachery Cogan, James K. Nuñez, Alexander P. Fields, Britt Adamson, Daniel N. Itzhak et al. « Pervasive functional translation of noncanonical human open reading frames ». Science 367, no 6482 (5 mars 2020) : 1140–46. http://dx.doi.org/10.1126/science.aay0262.
Texte intégralde Klein, Niek, Enrico Magnani, Michael Banf et Seung Yon Rhee. « microProtein Prediction Program (miP3) : A Software for Predicting microProteins and Their Target Transcription Factors ». International Journal of Genomics 2015 (2015) : 1–4. http://dx.doi.org/10.1155/2015/734147.
Texte intégralRodrigues, Vandasue L., Ulla Dolde, Bin Sun, Anko Blaakmeer, Daniel Straub, Tenai Eguen, Esther Botterweg-Paredes et al. « A microProtein repressor complex in the shoot meristem controls the transition to flowering ». Plant Physiology 187, no 1 (20 mai 2021) : 187–202. http://dx.doi.org/10.1093/plphys/kiab235.
Texte intégralEguen, Tenai, Daniel Straub, Moritz Graeff et Stephan Wenkel. « MicroProteins : small size – big impact ». Trends in Plant Science 20, no 8 (août 2015) : 477–82. http://dx.doi.org/10.1016/j.tplants.2015.05.011.
Texte intégralHong, Shin-Young, Bin Sun, Daniel Straub, Anko Blaakmeer, Lorenzo Mineri, Jonas Koch, Henrik Brinch-Pedersen et al. « Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling ». Proceedings of the National Academy of Sciences 117, no 42 (8 octobre 2020) : 26197–205. http://dx.doi.org/10.1073/pnas.2005198117.
Texte intégralWu, Qingqing, Kunyan Kuang, Mohan Lyu, Yan Zhao, Yue Li, Jing Li, Ying Pan, Hui Shi et Shangwei Zhong. « Allosteric deactivation of PIFs and EIN3 by microproteins in light control of plant development ». Proceedings of the National Academy of Sciences 117, no 31 (21 juillet 2020) : 18858–68. http://dx.doi.org/10.1073/pnas.2002313117.
Texte intégralThèses sur le sujet "Microproteins"
Thongyoo, Panumart. « Macrocyclic cysteine knot microproteins : total syntheses and biological activities ». Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5285.
Texte intégralDebreczeni, Judit Éva. « X-ray crystallographic studies on two cysteine-rich anticarcinogenic microproteins ». [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97260278X.
Texte intégralGraeff, Moritz [Verfasser], et Stephan [Akademischer Betreuer] Wenkel. « MicroProteins in the Regulation of Flowering Time / Moritz Graeff ; Betreuer : Stephan Wenkel ». Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1197694692/34.
Texte intégralAboye, Teshome Leta. « Engineering of the Ultra-stable Cystine Knot Framework of Microproteins : Design, Chemical Synthesis and Structural Studies ». Doctoral thesis, Uppsala universitet, Avdelningen för farmakognosi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-145749.
Texte intégralDevaux, Alexandre. « Rôle de la polyadénylation intronique dans la réponse des cellules cancéreuses au cisplatine ». Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL015.
Texte intégralDuring studies on alternative polyadenylation (APA), short transcripts ending in an alternative last exon were discovered, known as intronic polyadenylation (IPA). IPA is regulated by splicing factors (including U1 snRNP), polyadenylation factors and transcription elongation factors (including CDK12). IPA isoforms are regulated by genotoxic agents (inducing DNA damage), including UV radiation and doxorubicin. Conversely, CDK12 inhibitors increase both IPA in DNA repair genes and cellular sensitivity to genotoxic agents. IPA often occurs in the coding region of genes, generating carboxy-terminally altered proteins. However, IPA transcripts are also generated in the first introns of genes, known as 5'IPA. Many 5'IPA transcripts are degraded by the nuclear exosome, but some are abundant and have a low coding potential. Two of these, derived from the ASCC3 and CDKN1A genes, have non-coding functions. In addition, studies using Ribo-seq and mass spectrometry (MS) are showing the existence -in mRNAs and lncRNAs- of small open reading frames (sORF) encoding microproteins (miP, proteins of less than 100 aa) which can be functional. No miP has been reported in 5'IPA isoforms. Cisplatin (CisPt) is a DNA-crosslinking agent widely used in non-small cell lung cancer (NSCLC). My team observed, by 3'-seq in NSCLC cells, that CisPt increases the expression of IPA isoforms compared to canonical mRNAs (IPA:LE ratio) in many genes, and that some IPA isoforms are poorly associated with heavy polysomes and are derived from the region upstream of the annotated translation initiation site of the gene (5'UTR-IPA isoforms). My objectives were to determine the role of IPA in cell response to CisPt. I first looked at the role of 5'UTR-IPA isoforms. For two of them, derived from the PRKAR1B and PHF20 genes, I showed that their depletion by siRNA increased the survival of NSCLC cells to CisPt. These two isoforms are associated with light polysomal fractions. Analyses of Ribo-seq and MS databases revealed the existence of sORFs in these two isoforms. By transfecting vectors containing these 5'UTR-IPA isoforms and by tagging their sORFs, I observed by ImmunoFluorescence (IF) and Western Blot that the 5'UTR-IPA isoform of PRKAR1B encodes a miP. Deletion of this IPA isoform or mutation of the sORF ATG endogenously by CRISPR gave a phenotype similar to the siRNAs. This is the first 5'UTR-IPA isoform encoding a miP (miP-5'UTR-IPA). By cross-referencing our 3'-seq data with Ribo-seq and MS data, we identified around a hundred potential miP-5'UTR-IPA isoforms induced by CisPt. Secondly, I investigated the possibility of sensitizing NSCLC cells to CisPt by targeting U1 snRNP with an antisense oligonucleotide (U1-AMO), that induces IPA in many genes. In several NSCLC cell lines, I showed sensitization to CisPt by U1-AMO in terms of cell growth inhibition and DNA damage induction (ƴH2AX foci). This sensitization is linked to a reduced expression of the canonical mRNAs of DNA crosslinks repair pathways (Fanconi and nucleotide excision repair), as shown by 3'-seq and RT-qPCR. However, U1-AMO prevented CisPt- induced cell cycle block and the effects of CisPt on the IPA:LE ratio of many genes. My work shows the impact of IPA on the response of cancer cells to CisPt, and reveals a new genetic paradigm, called miP-5'UTR-IPA, in which genes produce short miP-encoding transcripts by IPA
Schmoldt, Hans-Ulrich. « Neue Enzyminhibitoren und Rezeptoragonisten durch Variation funktionaler Schleifen von Mikroproteinen ». Doctoral thesis, [S.l.] : [s.n.], 2005. http://webdoc.sub.gwdg.de/diss/2005/schmoldt.
Texte intégralQuinn, Stuart Aidan. « Microproteins and Epigenetic Remodeling in Cancer and Aging ». Thesis, 2021. https://doi.org/10.7916/d8-hwat-bq40.
Texte intégralDebreczeni, Judit Eva. « X-ray crystallographic studies on two cysteine-rich anticarcinogenic microproteins ». Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-B022-B.
Texte intégralDusi. « CYSTINE-KNOT PEPTIDES AND BBX MICROPROTEINS AS CONTROLLING FACTORS OF FLOWER AND FRUIT DEVELOPMENT ». Doctoral thesis, 2022. http://hdl.handle.net/11562/1074488.
Texte intégralDebreczeni, Judit Éva [Verfasser]. « X-ray crystallographic studies on two cysteine-rich anticarcinogenic microproteins / vorgelegt von Judit Éva Debreczeni ». 2004. http://d-nb.info/97260278X/34.
Texte intégralLivres sur le sujet "Microproteins"
Quinn, Stuart Aidan. Microproteins and Epigenetic Remodeling in Cancer and Aging. [New York, N.Y.?] : [publisher not identified], 2021.
Trouver le texte intégralChapitres de livres sur le sujet "Microproteins"
Fiume, Elisa, Niek de Klein, Seung Yon Rhee et Enrico Magnani. « A Framework for Discovering, Designing, and Testing MicroProteins to Regulate Synthetic Transcriptional Modules ». Dans Methods in Molecular Biology, 175–88. New York, NY : Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6396-6_12.
Texte intégralAlewood, Dianne, John L. Andrews et Stephen B. H. Kent. « Total chemical synthesis of the microprotein EETI II and analogs ». Dans Peptides 1990, 167–68. Dordrecht : Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_67.
Texte intégralHeitz, A., A. Padilla, L. Chiche, D. Le-Nguyen et B. Castro. « 3D Structure of a chimeric microprotein inhibiting both trypsin and carboxypeptidase A ». Dans Peptides 1990, 579–80. Dordrecht : Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_242.
Texte intégralKliemt, Jana, et Jörg Soppa. « Diverse Functions of Small RNAs (sRNAs) in Halophilic Archaea : From Non-coding Regulatory sRNAs to Microprotein-Encoding sRNAs ». Dans RNA Metabolism and Gene Expression in Archaea, 225–42. Cham : Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65795-0_10.
Texte intégralLe-Nguyen, Dung, Annie Heitz, Laurent Chiche, Mohammed El Hajji et Bertrand Castro. « Folding pathway study of EETI II, a knotted microprotein containing three disulfide bridges : Structural characterization of the stable two-bridge intermediate ». Dans Peptides 1992, 521–22. Dordrecht : Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_232.
Texte intégralDeppisch, R., E. Ritz, et G. Stein. « Characteristics of ß2-microglobulin metabolism ». Dans Dialysis Amyloid, 195–214. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780192624949.003.0009.
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