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Articles de revues sur le sujet « Metabolismo, Flusso »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Hammers, A. "Diagnostica per immagini cerebrale tramite tomografia a emissione di positroni in neurologia: dalla misurazione del flusso sanguigno e del metabolismo all’esplorazione della neurotrasmissione." EMC - Neurologia 15, no. 2 (2015): 1–9. http://dx.doi.org/10.1016/s1634-7072(15)70502-7.

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Martins, A. M. C. R. P. da F. "METABOLISMO DA GLUTAMINA NA CÉLULA TUMORAL." Arquivos do Instituto Biológico 70, no. 2 (2003): 231–37. http://dx.doi.org/10.1590/1808-1657v70p2312003.

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RESUMO Neoplasias são doenças com alterações no DNA, provocadas por diversos eventos.Sua origem é monoclonal e com desenvolvimento e instabilidade gênica, novos clones surgem. Os atributos neoplásicos (cariótipo, invasibilidade, suscetibilidade a anti-neoplásicos, ritmo de crescimento, suscetibilidade hormonal, capacidade metastática) são heterogêneos, exigindo fluxo energético alto, macromoléculas e nitrogênio. Assim, as vias metabólicas nessas células garantem-lhes precursores para a síntese de lipídeos estruturais e reguladores, DNA e RNA. Célula tumoral usa qualquer substrato como fonte en

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Medina-Galván, Julio, Juan Manuel Audelo-Naranjo, and José Alfredo Arreola-Lizárraga. "Importancia del monitoreo de procesos biogeoquímicos en lagunas costeras: Área Natural Protegida estero El Soldado como estudio de caso." Investigación y Ciencia de la Universidad Autónoma de Aguascalientes, no. 77 (May 31, 2019): 12–18. http://dx.doi.org/10.33064/iycuaa2019772087.

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Esta contribución presenta estimaciones de los flujos de nutrientes y el metabolismo neto en una laguna costera prístina del Golfo de California. Durante primavera se realizaron muestreos de variables del agua en la laguna y el mar adyacente. Los flujos de nutrientes y el metabolismo neto del ecosistema fueron estimados con el modelo biogeoquímico propuesto por el programa LOICZ (Interacciones Tierra Océano en la Zona Costera). La tasa de renovación del agua fue de 3 días. La laguna El Soldado funcionó como fuente de nitrógeno (+61mol día–1) y como sumidero de fósforo (-42 mol día–1). El metab

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Martin, W. R. Wayne, and Michael R. Hayden. "Cerebral Glucose and Dopa Metabolism in Movement Disorders." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, S3 (1987): 448–51. http://dx.doi.org/10.1017/s0317167100037896.

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ABSTRACT:The development of positron emission tomography (PET) has enabled us to perform in vivo measurements of certain aspects of regional cerebral function. Regional cerebral glucose metabolism may be readily quantified with [18F] fluoro-2-deoxyglucose (FDG) and presynaptic dopaminergic function may be studied with the labelled dopa analog 6-[18F] fluoro-L-dopa. We have applied a model to the analysis of 6-FD/PET data with which in vivo age-related changes in dopaminergic function may be demonstrated in normal subjects. With this technique, we have studied a series of asymptomatic MPTP-expo

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Sylvia, A. L., and C. A. Piantadosi. "Brain Oxygen Metabolism in Fluosol-43 Circulated Rats." Biomaterials, Artificial Cells and Artificial Organs 16, no. 1-3 (1988): 679–80. http://dx.doi.org/10.3109/10731198809132637.

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Medina-Galván, Julio, Carmen Cristina Osuna-Martínez, Gustavo Padilla-Arredondo, et al. "Estado trófico, dinámica de nutrientes y metabolismo neto de una laguna costera subtropical (Golfo de California) receptora de aguas residuales." Revista Internacional de Contaminación Ambiental 38 (October 31, 2022): 449–63. http://dx.doi.org/10.20937/rica.54396.

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Se evaluaron el estado trófico, la dinámica de nutrientes y el metabolismo neto de una laguna costera subtropical ubicada en la costa este del Golfo de California. La laguna Santa María es un sistema receptor de aguas residuales urbanas, camaronícolas y agrícolas. En la laguna y el mar adyacente se realizaron muestreos de agua en verano e invierno para obtener información de temperatura, salinidad, oxígeno disuelto, nutrientes inorgánicos disueltos y clorofila a. El estado trófico se estimó con el índice TRIX, mientras que los flujos de nutrientes y el metabolismo neto se estimaron con el mode

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Haggstrom, Lucy R., Julia A. Nelson, Eva A. Wegner, and Gideon A. Caplan. "2-18F-fluoro-2-deoxyglucose positron emission tomography in delirium." Journal of Cerebral Blood Flow & Metabolism 37, no. 11 (2017): 3556–67. http://dx.doi.org/10.1177/0271678x17701764.

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Delirium is a common, serious, yet poorly understood syndrome. Growing evidence suggests cerebral metabolism is fundamentally disturbed; however, it has not been investigated using 2-18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) in delirium. This prospective study thus explored FDG PET patterns of cerebral glucose metabolism in older inpatients with delirium. A particular emphasis was on the posterior cingulate cortex (PCC), a key region for attention, which is a central feature of delirium. Delirium scans were compared with post-delirium scans using visual analysis and se

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Rodríguez Jàcome, Gabriela, and Asunción Blanco-Romero. "Metabolismo insular: flujos y retos del desarrollo territorial en las Islas Galápagos (Ecuador)." Anales de Geografía de la Universidad Complutense 38, no. 1 (2018): 113–35. http://dx.doi.org/10.5209/aguc.60471.

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Los espacios insulares son territorios cuyo tamaño, disponibilidad de recursos y accesibilidad son limitados. La insularidad marca unas dinámicas territoriales singulares en estos espacios, que a pesar de su gran valor estratégico los hacen dependientes de las relaciones con el exterior. Las islas Galápagos, pertenecientes a la República del Ecuador, constituyen un caso muy particular de estudio. Si bien las categorías de Patrimonio Natural Mundial y Parque Nacional le dan condiciones de protección de la naturaleza, únicas en el mundo, sus habitantes soportan la misma, o incluso mayor, problem

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Dutta, Prasanta, Travis C. Salzillo, Shivanand Pudakalakatti, et al. "Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging." Cells 8, no. 4 (2019): 340. http://dx.doi.org/10.3390/cells8040340.

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Precisely measuring tumor-associated alterations in metabolism clinically will enable the efficient assessment of therapeutic responses. Advances in imaging technologies can exploit the differences in cancer-associated cell metabolism as compared to normal tissue metabolism, linking changes in target metabolism to therapeutic efficacy. Metabolic imaging by Positron Emission Tomography (PET) employing 2-fluoro-deoxy-glucose ([18F]FDG) has been used as a routine diagnostic tool in the clinic. Recently developed hyperpolarized Magnetic Resonance (HP-MR), which radically increases the sensitivity

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Gierlinger, Sylvia, Friedrich Hauer, Gudrun Pollack, and Fridolin Krausmann. "Metabolismo y paisaje acuático en una ciudad en la industrialización: una evaluación cuantitativa del uso de los recursos y su relación con la transformación del paisaje acuático urbano en Viena del siglo XIX." Agua y Territorio, no. 7 (June 30, 2016): 109–24. http://dx.doi.org/10.17561/at.v0i7.2966.

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En este trabajo tomamos la perspectiva del metabolismo urbano para investigar la transformación del paisaje acuático de Viena. Mostramos cómo el metabolismo de la ciudad se entrelaza profundamente con el paisaje acuático y cómo esta relación cambió durante la industrialización. El eje metodológico de esta investigación parte de una evaluación cuantitativa del uso de los recursos urbanos utilizando métodos de contabilidad de flujos metabólicos. Se presentan los datos sobre la entrada de energía (1800 a 1914), materiales (1830-1874) y agua (1860 a 1910), así como los flujos de las aguas residual

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Kawagoe, Fumihiro, Sayuri Mototani, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, and Atsushi Kittaka. "Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism." International Journal of Molecular Sciences 22, no. 21 (2021): 11863. http://dx.doi.org/10.3390/ijms222111863.

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Two 24-fluoro-25-hydroxyvitamin D3 analogues (3,4) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D3 side-chain C24 position was achieved via Sharpless dihydroxylation, and a deoxyfluorination reaction was utilized for the fluorination step. Comparison between (24R)- and (24S)-24-fluoro-25-hydroxyvitamin D3 revealed that the C24-R-configuration isomer 4 was more resistant to CYP24A1-dependent metabolism than its 24S-isomer 3. The new synthetic route of the CYP24A1 main metabolite (24R)-24,25-dihydroxyvitamin D3 (6) and its 24S-isomer (5) was also stu

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Honka, Miikka-Juhani, Eleni Rebelos, Simona Malaspina, and Pirjo Nuutila. "Hepatic Positron Emission Tomography: Applications in Metabolism, Haemodynamics and Cancer." Metabolites 12, no. 4 (2022): 321. http://dx.doi.org/10.3390/metabo12040321.

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Evaluating in vivo the metabolic rates of the human liver has been a challenge due to its unique perfusion system. Positron emission tomography (PET) represents the current gold standard for assessing non-invasively tissue metabolic rates in vivo. Here, we review the existing literature on the assessment of hepatic metabolism, haemodynamics and cancer with PET. The tracer mainly used in metabolic studies has been [18F]2-fluoro-2-deoxy-D-glucose (18F-FDG). Its application not only enables the evaluation of hepatic glucose uptake in a variety of metabolic conditions and interventions, but based

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Offer, J., J. C. Metcalfe, and G. A. Smith. "The uptake of 3H-labelled monodeoxyfluoro-myo-inositols into thymocytes and their incorporation into phospholipid in permeabilized cells." Biochemical Journal 291, no. 2 (1993): 553–60. http://dx.doi.org/10.1042/bj2910553.

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Monodeoxyfluoro-myo-inositols were applied to electropermeabilized and intact thymocyte preparations to study their metabolism and uptake in order to investigate their suitability as potential inhibitors of phosphoinositide-mediated cellular responses. Only three of the monodeoxyfluoro-myo-inositols were incorporated into the phospholipids of thymocytes: 1D-3-deoxy-3-fluoro-myo-inositol, 5-deoxy-5-fluoro-myo-inositol and 1D-6-deoxy-6-fluoro-myo-inositol, all of which were weaker substrates for phosphatidylinositol synthase than was myo-inositol. The 3-, 5- and 6-fluoro analogues also behaved a

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Soares, Pierre Castro, Celso Akio Maruta, Maria Claudia Araripe Sucupira, et al. "Diagnóstico de carência energética em bovinos por testes de metabolismo ruminal." Brazilian Journal of Veterinary Research and Animal Science 43, no. 1 (2006): 33. http://dx.doi.org/10.11606/issn.1678-4456.bjvras.2006.26515.

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Avaliou-se o metabolismo ruminal de bovinos submetidos ou não a dietas carentes em energia, por meio de provas bioquímicas e funcionais no fluido ruminal e urinário com finalidade diagnóstica. Para tal, foram utilizados 10 garrotes mestiços providos de cânula ruminal que foram divididos em dois grupos, ou seja: controle (C; n=4) dieta balanceada para ganho diário de 900 g e carência pronunciada de energia (CP; n=6) recebendo 30% a menos do nível de mantença em energia. Após os bovinos serem alimentados por 140 d foram coletadas amostras de fluido ruminal e urina antes da alimentação e nas 1ª,

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Novak, Marie M. A., Katherine Shimizu, and Barry J. Blackburn. "A fluorine-19 nuclear magnetic resonance study of 5-fluorouracil metabolism in Mesocestoides corti tetrathyridia." Canadian Journal of Zoology 70, no. 2 (1992): 406–10. http://dx.doi.org/10.1139/z92-061.

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Fluorine-19 nuclear magnetic resonance spectra of live tetrathyridia of Mesocestoides corti incubated in 10 mM 5-fluorouracil (5-FU) showed that these larvae metabolize 5-FU to α-fluoro-β-ureidopropionic acid (FUPA), α-fluoro-β-alanine (FBA1) and fluoronucleotides (FNuct). This metabolism is predominantly catabolic, since as time progressed (up to 7 h) the 5-FU signal continuously decreased while the FBA1 signal correspondingly increased and the composite FNuct peak remained small. Similar spectra were obtained from acid extracts of tetrathyridia, except that an additional, very small fluoronu

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Barrio, Jorge R., Sung-Cheng Huang, Dan-Chu Yu, et al. "Radiofluorinated L-m-Tyrosines: New In-Vivo Probes for Central Dopamine Biochemistry." Journal of Cerebral Blood Flow & Metabolism 16, no. 4 (1996): 667–78. http://dx.doi.org/10.1097/00004647-199607000-00018.

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In this work, we introduce 6-[18F]fluoro-L- m-tyrosine (6-FMT) and compare its in-vivo kinetic and biochemical behaviors in monkeys and rodents with those of 4-FMT and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (DOPA) (FDOPA). These radiofluorinated m-tyrosine presynaptic dopaminergic probes, resistant to peripheral 3- O-methylation, offer a nonpharmacological alternative to the use of catechol- O-methyltransferase inhibitors. Like FDOPA, 4-FMT and 6-FMT are analogs that essentially follow the L-DOPA pathway of central metabolism. After i.v. administration in nonhuman primates and rodents, the

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Junck, Larry, Sid Gilman, Jill R. Rothley, Annette T. Betley, Robert A. Koeppe, and Richard D. Hichwa. "A Relationship between Metabolism in Frontal Lobes and Cerebellum in Normal Subjects Studied with PET." Journal of Cerebral Blood Flow & Metabolism 8, no. 6 (1988): 774–82. http://dx.doi.org/10.1038/jcbfm.1988.132.

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Lesions of one cerebral hemisphere are associated with decreased glucose metabolism, oxygen metabolism, and blood flow in the contralateral cerebellar hemisphere. We used positron emission tomography to look for a functional relationship in cerebral metabolism between the cerebral cortex and the contralateral cerebellum in normal human subjects. Twenty-four normal subjects were scanned with [18F]fluoro-2-deoxy-D-glucose while in a resting state. Asymmetry in local CMRglu (LCMRglu) in the frontal cortex was strongly correlated with asymmetry in LCMRglu in the opposite direction in the cerebella

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Hunt, Aoife, Uwe Haberkorn, Johannes Schröder, and Peter Schönknecht. "Neural Correlates of Executive Dysfunction in Prodromal and Manifest Alzheimer’s Disease." GeroPsych 24, no. 2 (2011): 77–81. http://dx.doi.org/10.1024/1662-9647/a000038.

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Executive function is frequently impaired in patients with Alzheimer’s disease (AD) and its prodromal stage, and can be assessed using the Trail-Making Test (TMT). We aimed to elicit the neural and cognitive correlates of TMT subtests using positron emission tomography with 18-fluoro-D-deoxy-glucose, and neuropsychological testing in 20 patients with prodromal or manifest AD as well as 14 controls. TMT-A correlated with glucose metabolism in the left middle frontal cortex, TMT-B performance correlated with the metabolism in the right middle frontal cortex and the right precentral gyrus, and TM

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MacLusky, N. J., L. C. Krey, B. Parsons, et al. "Are catechol oestrogens obligatory mediators of oestrogen action in the central nervous system? II. Potencies of natural and synthetic oestrogens for induction of gonadotrophin release and female sexual behaviour in the rat." Journal of Endocrinology 110, no. 3 (1986): 499–505. http://dx.doi.org/10.1677/joe.0.1100499.

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ABSTRACT The role of catechol oestrogen formation in the mechanism by which circulating oestrogens facilitate gonadotrophin release and female sexual behaviour was explored in adult female rats. The effects of oestradiol-17β were compared with those of a group of oestrogens with either a reduced affinity for oestrogen receptors (oestradiol-17α) or a reduced ability to act as substrates for catechol oestrogen formation (2-fluoro-oestradiol, 4-fluoro-oestradiol and moxestrol (11β-methoxy-17α-ethynyloestradiol)). Rats were ovariectomized on the evening of dioestrus day 1 of the 4-day oestrous cyc

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Pfeiffer, D. G., N. J. MacLusky, E. Barnea, et al. "Are catechol oestrogens obligatory mediators of oestrogen action in the central nervous system? I. Characterization of pharmacological probes with different receptor binding affinities and catechol oestrogen formation rates." Journal of Endocrinology 110, no. 3 (1986): 489–97. http://dx.doi.org/10.1677/joe.0.1100489.

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ABSTRACT In an attempt to define pharmacological probes with which to test the role of catechol oestrogen formation in the central nervous system, five oestrogens (oestradiol-17β, oestradiol-17α, 4-fluoro-oestradiol, 2-fluoro-oestradiol and moxestrol (11β-methoxy-17α-ethynyloestradiol) were studied for binding to oestrogen receptors and conversion to catechol metabolites. Binding to cytosol oestrogen receptors was measured in the hypothalamus–preoptic area–amygdala (HPA), pituitary gland and uterus of ovariectomized rats. Conversion to catechol oestrogens was tested in microsomes from the HPA,

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Berkowitz, B. A., T. Moriyama, H. M. Fales, R. A. Byrd, and R. S. Balaban. "In vivo metabolism of 3-deoxy-3-fluoro-D-glucose." Journal of Biological Chemistry 265, no. 21 (1990): 12417–23. http://dx.doi.org/10.1016/s0021-9258(19)38363-2.

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Gallego Sánchez-Torij, J., E. Larrumbide Gómez-Rubiera, and C. Bedoya Frutos. "Metabolismo en los edificios. Estudio de medidas para el ahorro del consumo de agua en tres centros docentes en Madrid." Informes de la Construcción 72, no. 557 (2020): 325. http://dx.doi.org/10.3989/ic.67829.

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Estudios previos han investigado sobre el desempeño energético de centros docentes. Sin embargo, no parece haberse explorado suficientemente la relación entre consumo de energía y consumo de agua en este tipo de edificios. Este artículo presenta los resultados de un estudio empírico, basado en la metodología de la auditoría energética operativa, realizado en tres centros docentes ubicados en la Comunidad de Madrid. Los resultados sugieren que las medidas de ahorro en el consumo de agua, como implantar perlizadores, temporizadores o doble pulsadores, son relevantes en cuanto a la mejora de la e

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Kim, Shin, Hyon-Ah Yi, Kyoung Sook Won, Ji Soo Lee, and Hae Won Kim. "Association between Visceral Adipose Tissue Metabolism and Alzheimer’s Disease Pathology." Metabolites 12, no. 3 (2022): 258. http://dx.doi.org/10.3390/metabo12030258.

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The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer’s disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A vox

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Parrado Rodríguez, Cristhian, Andrea Cevallos Aráuz, and Leonardo Arias Álvarez. "Metabolismo urbano en la ciudad de Baeza, Ecuador. Análisis de sus flujos del agua." Bitácora Urbano Territorial 28, no. 3 (2018): 131–41. http://dx.doi.org/10.15446/bitacora.v28n3.72183.

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A partir del concepto de metabolismo urbano el artículo analiza el estado de los flujos de entrada y salida del agua de la zona antigua de la ciudad de Baeza, la cabecera cantonal de Quijos (Ecuador). Detalla la existencia de procesos metabólicos entrópicos donde no hay una reintegración efectiva del recurso hídrico al ecosistema urbano. Igualmente, desde la visión de ecobarrio presenta una propuesta de intervención que establece lineamientos para generar una mejor recirculación del agua en el territorio. En esa medida, el artículo procura incentivar la discusión sobre cómo lograr un equilibri

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March Corbella, Hug, and David Saurí Pujol. "Flujos de agua, flujos de capital: sistemas de abastecimiento y gobernanza del agua en Madrid y Barcelona." Investigaciones Geográficas, no. 51 (April 15, 2010): 7. http://dx.doi.org/10.14198/ingeo2010.51.01.

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El agua es un elemento clave para el sustento del metabolismo de las ciudades. Sin embargo, los orígenes, métodos de «producción», y modelos de gestión del flujo de urbano de agua pueden variar geográficamente. En este artículo se comparan los sistemas de abastecimiento y gestión de agua potable en las dos principales regiones metropolitanas del Estado: Barcelona y Madrid. En Barcelona, el agua procede de distintas fuentes entre las cuales destaca la desalación, vigente desde el verano de 2009. En Madrid, el sistema de abastecimiento depende fuertemente de las aguas superficiales procedentes d

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Merecz-Sadowska, Anna, Vera M. S. Isca, Przemysław Sitarek та ін. "Exploring the Anticancer Potential of Semisynthetic Derivatives of 7α-Acetoxy-6β-hydroxyroyleanone from Plectranthus sp.: An In Silico Approach". International Journal of Molecular Sciences 25, № 8 (2024): 4529. http://dx.doi.org/10.3390/ijms25084529.

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The diterpene 7α-acetoxy-6β-hydroxyroyleanone isolated from Plectranthus grandidentatus demonstrates promising antibacterial, anti-inflammatory and anticancer properties. However, its bioactivity may be enhanced via strategic structural modifications of such natural products through semisynthesis. The anticancer potential of 7α-acetoxy-6β-hydroxyroyleanone and five derivatives was analyzed in silico via the prediction of chemicals absorption, distribution, metabolism, excretion, and toxicity (ADMET), quantum mechanical calculations, molecular docking and molecular dynamic simulation. The prote

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Wiese, Claudia, Marianne Cogoli-Greuter, Mario Argentini, Thomas Mäder, Regin Weinreich, and Kaspar H. Winterhalter. "Metabolism of 5-fluoro-DOPA and 6-fluoro-DOPA enantiomers in aggregating cell cultures of fetal rat brain." Biochemical Pharmacology 44, no. 1 (1992): 99–105. http://dx.doi.org/10.1016/0006-2952(92)90043-i.

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Montoya García, Dainiz Noray, Salvador Adame-Martínez, Edel Cadena-Vargas, Verónica Martínez-Miranda, and Cristián Julian Diaz Alvarez. "Metabolismo urbano de los municipios de Toluca y Metepec, Estado de México, México." Quivera Revista de Estudios Territoriales 25, no. 2 (2023): 107. http://dx.doi.org/10.36677/qret.v25i2.19063.

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Las ciudades modernas presentan problemas ambientales y sociales debido a su metabolismo lineal, lo cual propicia un colapso inminente. Este trabajo da cuenta del metabolismo urbano de los municipios Toluca y Metepec localizados en la parte central de México. Para ello se empleó el Análisis de Flujos de Materiales y Energía (AFME) de 2000 a 2019 considerando a ambas localidades como sistemas termodinámicos abiertos. Las entradas fueron: consumos de electricidad, de combustible y de agua; y las salidas: emisiones de CO2 (derivados de la electricidad y quema de gasolinas), aguas residuales y gen

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Reith, Jakob, Suzan Dyve, Hiroto Kuwabara, Mark Guttman, Mirko Diksic, and Albert Gjedde. "Blood—Brain Transfer and Metabolism of 6-[18F]Fluoro-L-DOPA in Rat." Journal of Cerebral Blood Flow & Metabolism 10, no. 5 (1990): 707–19. http://dx.doi.org/10.1038/jcbfm.1990.124.

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In a study designed to reveal the rates of blood–brain transfer and decarboxylation of fluoro-L-3,4-dihydroxyphenylalanine (FDOPA), we discovered a major discrepancy between the DOPA decarboxylase activity reported in the literature and the rate of FDOPA decarboxylation measured in the study. “Donor” rats received intravenous injections of 6 mCi fluorine-18-labeled FDOPA. The donor rats synthesized methyl-FDOPA. Arterial plasma, containing both FDOPA and methyl-FDOPA, was sampled from the donor rats at different times and reinjected into “recipient” rats in which it circulated for 20 s. The bl

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Feng, Han, Xiaobo Wang, Jian Chen, et al. "Nuclear Imaging of Glucose Metabolism: Beyond 18F-FDG." Contrast Media & Molecular Imaging 2019 (March 26, 2019): 1–12. http://dx.doi.org/10.1155/2019/7954854.

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Glucose homeostasis plays a key role in numerous fundamental aspects of life, and its dysregulation is associated with many important diseases such as cancer. The atypical glucose metabolic phenomenon, known as the Warburg effect, has been recognized as a hallmark of cancer and serves as a promising target for tumor specific imaging. At present, 2-deoxy-2-[18F]fluoro-glucose (18F-FDG)-based positron emission tomography/computed tomography (PET/CT) represented the state-of-the-art radionuclide imaging technique for this purpose. The powerful impact of 18F-FDG has prompted intensive research eff

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Da Silva, Eduardo Valdemar, Thaiz Ferreira Galvão, Mariana Dourado Cruz, and Jaim Simões De Oliveira. "APLICAÇÃO DA LIPIDÔMICA NA DOENÇA DE ALZHEIMER." REVISTA FOCO 16, no. 9 (2023): e3010. http://dx.doi.org/10.54751/revistafoco.v16n9-197.

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O metabolismo lipídico tem uma função significativa no sistema nervoso central e a doença de Alzheimer é uma doença senil relacionada à idade, que é caracterizada por degeneração nervosa. O desenvolvimento patológico da doença de Alzheimer está intimamente relacionado aos distúrbios do metabolismo dos lipídios. Como o cérebro tem um alto teor de lipídios, o perfil lipidômico pode oferecer novos “caminhos” sobre a doença de Alzheimer. Assim, o objetivo do estudo foi avaliar a aplicação da lipidômica no auxílio da diversidade e especificidade das características lipídicas, relacionando com a doe

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Li, Jing, Yumei Wang, Kejie He, et al. "Effect of Acupuncture at LR3 on Cerebral Glucose Metabolism in a Rat Model of Hypertension: A 18F-FDG-PET Study." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/5712857.

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Our objective was to investigate the effect of acupuncture at LR3 on cerebral glucose metabolism in spontaneously hypertensive rats (SHRs). We used 18F-2-fluoro-deoxy-D-glucose positron emission tomography (18F-FDG-PET) to examine the effects of acupuncture at LR3 on cerebral glucose metabolism in SHRs. SHRs were randomly allocated to receive no treatment (SHR group), needling at LR3 (SHR + LR3 group), or sham needling (SHR + sham group). Rats received 10 min acupuncture once per day for 7 days and were compared to normotensive Wistar Kyoto (WKY) rats. Blood pressure (BP) measurement and PET w

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Huang, Yung-Cheng, Chien-Chin Hsu, Wei-Che Lin, et al. "Effects of Metformin on the Cerebral Metabolic Changes in Type 2 Diabetic Patients." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/694326.

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Metformin, a widely used antidiabetic drug, has numerous effects on human metabolism. Based on emerging cellular, animal, and epidemiological studies, we hypothesized that metformin leads to cerebral metabolic changes in diabetic patients. To explore metabolism-influenced foci of brain, we used 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography for type 2 diabetic patients taking metformin (MET,n=18), withdrawing from metformin (wdMET,n=13), and not taking metformin (noMET,n=9). Compared with the noMET group, statistical parametric mapping showed that the MET group had clusters

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Baek, Suji, Jisu Kim, Byung Seok Moon, et al. "Camphene Attenuates Skeletal Muscle Atrophy by Regulating Oxidative Stress and Lipid Metabolism in Rats." Nutrients 12, no. 12 (2020): 3731. http://dx.doi.org/10.3390/nu12123731.

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Sarcopenia- or cachexia-related muscle atrophy is due to imbalanced energy metabolism and oxidative stress-induced muscle dysfunction. Monoterpenes play biological and pharmacological reactive oxygen species (ROS) scavenging roles. Hence, we explored the effects of camphene, a bicyclic monoterpene, on skeletal muscle atrophy in vitro and in vivo. We treated L6 myoblast cells with camphene and then examined the ROS-related oxidative stress using Mito TrackerTM Red FM and anti-8-oxoguanine antibody staining. To investigate lipid metabolism, we performed real-time polymerase chain reactions, holo

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Daniellou, Richard, Hongyan Zheng, and David RJ Palmer. "Kinetics of the reaction catalyzed by inositol dehydrogenase from Bacillus subtilis and inhibition by fluorinated substrate analogs." Canadian Journal of Chemistry 84, no. 4 (2006): 522–27. http://dx.doi.org/10.1139/v06-033.

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Inositol dehydrogenase (EC 1.1.1.18) from Bacillus subtilis catalyzes the oxidation of myo-inositol to scyllo-inosose by transfer of the equatorial hydride of the substrate to NAD+. This is a key enzyme in the metabolism of myo-inositol, a primary carbon source for soil bacteria. In light of our recent discovery that the enzyme has a broad substrate spectrum while maintaining high stereoselectivity, we seek a more thorough understanding of the enzyme and its active site. We have examined the kinetics of the recombinant enzyme, and synthesized fluorinated substrate analogues as competitive inhi

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Firnau, G., S. Sood, R. Chirakal, C. Nahmias, and E. S. Garnett. "Cerebral Metabolism of 6?[18F]Fluoro-l-3,4-Dihydroxyphenylalanine in the Primate." Journal of Neurochemistry 48, no. 4 (1987): 1077–82. http://dx.doi.org/10.1111/j.1471-4159.1987.tb05629.x.

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Darland, G. K., R. Hajdu, H. Kropp, F. M. Kahan, R. W. Walker, and W. J. Vandenheuvel. "Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine." Drug Metabolism and Disposition 14, no. 6 (1986): 668–73. https://doi.org/10.1016/s0090-9556(25)08992-5.

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GRUN, Bernhard R., Ulrike BERGER, Franz OBERDORFER, et al. "Metabolism and actions of 2-deoxy-2-fluoro-d-galactose in vivo." European Journal of Biochemistry 190, no. 1 (1990): 11–19. http://dx.doi.org/10.1111/j.1432-1033.1990.tb15539.x.

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Sbrissa, Diego, J. M. McIntosh, and Norman F. Taylor. "The metabolism of 4-deoxy-4-fluoro-d-glucose in Pseudomonas putida." Carbohydrate Research 203, no. 2 (1990): 271–80. http://dx.doi.org/10.1016/0008-6215(90)80024-w.

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Fraternale, Alessandra, Luigia Rossi, and Mauro Magnani. "Encapsulation, metabolism and release of 2-fluoro-ara-AMP from human erythrocytes." Biochimica et Biophysica Acta (BBA) - General Subjects 1291, no. 2 (1996): 149–54. http://dx.doi.org/10.1016/0304-4165(96)00059-1.

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Mouttaki, Housna, Mark A. Nanny, and Michael J. McInerney. "Metabolism of Hydroxylated and Fluorinated Benzoates by Syntrophus aciditrophicus and Detection of a Fluorodiene Metabolite." Applied and Environmental Microbiology 75, no. 4 (2008): 998–1004. http://dx.doi.org/10.1128/aem.01870-08.

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ABSTRACT Transformations of 2-hydroxybenzoate and fluorobenzoate isomers were investigated in the strictly anaerobic Syntrophus aciditrophicus to gain insight into the initial steps of the metabolism of aromatic acids. 2-Hydroxybenzoate was metabolized to methane and acetate by S. aciditrophicus and Methanospirillum hungatei cocultures and reduced to cyclohexane carboxylate by pure cultures of S. aciditrophicus when grown in the presence of crotonate. Under both conditions, transient accumulation of benzoate but not phenol was observed, indicating that dehydroxylation occurred prior to ring re

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Vitti, Dorinha Miriam Silber Schmidt, Carlos Eduardo Furtado, João Batista da Silva Quadros, et al. "Efeitos de diferentes níveis de cálcio dietético na cinética de cálcio e fósforo em eqüinos." Revista Brasileira de Zootecnia 37, no. 3 (2008): 478–86. http://dx.doi.org/10.1590/s1516-35982008000300013.

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Objetivou-se estudar o metabolismo de cálcio (Ca) e fósforo (P) nos eqüinos em crescimento que receberam diferentes níveis de suplementação de Ca: 0,15; 0,45 e 0,75% na dieta, utilizando-se o modelo determinístico e compartimental. Foram utilizadas informações sobre o estudo de metabolismo e cinética de Ca e P em tecidos, obtidas pela técnica da diluição isotópica. Constatou-se que os níveis dietéticos de Ca tiveram influência na absorção real do Ca, sendo menor para o nível 0,15% (4,97 g Ca/dia). As trocas de Ca entre o sangue e o trato digestivo foram menores para o nível 0,15%. A mobilizaçã

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Murakami, Eisuke, Congrong Niu, Haiying Bao та ін. "The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase". Antimicrobial Agents and Chemotherapy 52, № 2 (2007): 458–64. http://dx.doi.org/10.1128/aac.01184-07.

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ABSTRACT β-d-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) is a potent inhibitor of hepatitis C virus (HCV) RNA replication in an HCV replicon assay. The 5′-triphosphate of PSI-6130 is a competitive inhibitor of the HCV RNA-dependent RNA polymerase (RdRp) and acts as a nonobligate chain terminator. Recently, it has been shown that the metabolism of PSI-6130 also results in the formation of the 5′-triphosphate of the uridine congener, β-d-2′-deoxy-2′-fluoro-2′-C-methyluridine (PSI-6206; RO2433). Here we show that the formation of the 5′-triphosphate of RO2433 (RO2433-TP) requires the deamin

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Bøgesø, Klaus P., and Michael Bech Sommer. "The effect of aromatic substitution on neuroleptic activity in 1-piperazino-3-phenylindans. A comparison based on a new D-2 receptor model with corresponding 10-piperazino-10,11-dihydrodibenzo[b,f]thiepins." Collection of Czechoslovak Chemical Communications 56, no. 11 (1991): 2456–67. http://dx.doi.org/10.1135/cccc19912456.

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The validity of a new dopamine D-2 receptor interaction model based on conformational analysis and least-squares superimposition studies of the indan derivative tefludazine and the thiepin derivative octoclothepin was further tested by comparison of the effect of aromatic substitution on D-2 antagonistic activity in two series of indan and thiepin derivatives. The indan series include new derivatives substituted in the 4-, 7-, 2’- and 3’-position. The substitution effects were largely parallel with one important exception: Only 6-substituted indans have significant neuroleptic activity while b

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Huber, M., B. Kittner, C. Hojer, G. R. Fink, M. Neveling, and W. D. Heiss. "Effect of Propentofylline on Regional Cerebral Glucose Metabolism in Acute Ischemic Stroke." Journal of Cerebral Blood Flow & Metabolism 13, no. 3 (1993): 526–30. http://dx.doi.org/10.1038/jcbfm.1993.68.

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In a randomized double-blind placebo-controlled study in 30 patients with acute ischemic stroke, the effect of the adenosine uptake blocker propentofylline on regional brain glucose metabolism (rCMRglu) was investigated using repeated positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-d-glucose (FDG). Treatment was initiated within 48 h after onset of symptoms. The clinical course was followed for 3 months. In the propentofylline group, after 14 days rCMRglu was increased in the infarct by 37.3% and was practically unchanged in other brain regions, whereas in the control group gluco

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Hasselbalch, S. G., P. L. Madsen, L. P. Hageman, et al. "Changes in cerebral blood flow and carbohydrate metabolism during acute hyperketonemia." American Journal of Physiology-Endocrinology and Metabolism 270, no. 5 (1996): E746—E751. http://dx.doi.org/10.1152/ajpendo.1996.270.5.e746.

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During starvation, brain energy metabolism in humans changes toward oxidation of ketone bodies. To investigate if this shift is directly coupled to circulating blood concentrations of ketone bodies, we measured global cerebral blood flow (CBF) and global cerebral carbohydrate metabolism with the Kety-Schmidt technique before and during intravenous infusion with ketone bodies. During acute hyperketonemia (mean beta-hydroxybutyrate blood concentration 2.16 mM), cerebral uptake of ketones increased from 1.11 to 5.60 mumol.100 g-1.min-1, counterbalanced by an equivalent reduction of the cerebral g

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Melega, William P., Scott T. Grafton, Sung-Cheng Huang, Nagichettiar Satyamurthy, Michael E. Phelps, and Jorge R. Barrio. "L-6-[18F]Fluoro-DOPA Metabolism in Monkeys and Humans: Biochemical Parameters for the Formulation of Tracer Kinetic Models with Positron Emission Tomography." Journal of Cerebral Blood Flow & Metabolism 11, no. 6 (1991): 890–97. http://dx.doi.org/10.1038/jcbfm.1991.154.

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Characterization of peripheral and cerebral l-3,4-dihydroxy-6-[18F]fluorophenylalanine (FDOPA) metabolism in humans and monkeys has shown FDOPA to be an analogue of l-DOPA for the study of the dopaminergic system with positron emission tomography (PET). In human studies with carbidopa pretreatment, l-3,4-dihydroxy-6-[18F]fluoro-3- O-methylphenylalanine (3-OMFD) was the only FDOPA metabolite detected in plasma. FDOPA administration in monkeys resulted in selective accumulation of FDOPA metabolites in central dopaminergic regions, whereas 3-OMFD of peripheral origin was uniformly distributed amo

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García Serna, María Isabel, Tito Morales-Pinzón, and Jhoniers Guerrero Erazo. "Análisis de flujos de agua en áreas metropolitanas desde la perspectiva del metabolismo urbano." Luna Azul, no. 39 (June 6, 2014): 234–49. http://dx.doi.org/10.17151/luaz.2014.39.14.

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Ustsinau, Usevalad, Lukas Nics, Marcus Hacker, and Cecile Philippe. "A Fully Automated Synthesis of 14-(R,S)-[18F]fluoro-6-thia-heptadecanoic Acid ([18F]FTHA) on the Elixys Radiosynthesizer." Pharmaceuticals 17, no. 3 (2024): 318. http://dx.doi.org/10.3390/ph17030318.

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14-(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA) is a radiocompound for imaging the fatty acid circulation by positron emission tomography. A revived interest in imaging of lipid metabolism led us to a constant tracer production over three years, initially using a conventional vessel-based synthesizer and later transitioning to the cassette-based Elixys synthesizer. On the Elixys module, the radiochemical yield of [18F]FTHA could be increased by more than two times, reaching 13.01 ± 5.63% at the end of the synthesis, while maintaining necessary quality control results.

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Conceição, Luís, Sofia Morais, and Cláudia Aragão. "Fluxos de nutrientes em larvas de peixes: aplicação de técnicas com marcadores isotópicos e de modelação." Revista Brasileira de Zootecnia 36, suppl (2007): 11–20. http://dx.doi.org/10.1590/s1516-35982007001000002.

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Um modelo mecanístico que simule o crescimento durante a fase larvar de peixes deverá contribuir para um melhor conhecimento do processo de crescimento e respectivo metabolismo, com a intenção de elucidar as suas necessidades alimentares e desenvolver estratégias de alimentação adequadas. O modelo desenvolvido simula o crescimento e a evolução da composição bioquímica das larvas ao longo do tempo. O modelo depende essencialmente do consumo de alimento, sendo os nutrientes absorvidos usados para a produção de energia ou em processos de biossíntese e é baseado na estequiometria do metabolismo in

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