Articles de revues sur le sujet « Mehtić family »

Abstract Islamic mehir practices (dower) and other financial arrangements during a marriage reveal how marriage, gender and religion are understood and reconfigured in Istanbul today. Drawing on religious women's narratives of mehir and gifts of gold, this article examines the complex interplay between economic transactions and intimate marital relationships in Istanbul, as well as the relation between my interlocutors’ practices of mehir and wedding gifts and their sense of propriety. It suggests that women's ways of understanding and practising economic marriage transactions are ambivalently shaped by intimate entanglements of religion, nuclear family, conjugal love, secular civil law, and reputation and honour. Women uneasily navigate the ambivalences of the intimate sphere as they make decisions and engage in practices related to economic marriage transactions.

The Mehri Language is an endangered language spoken in eastern Yemen, a sub-group of the Semitic language family, and a Southern Arabic language. The syntax of Mehri wh-questions has not been explored within minimalism; hence, there is a morpho-syntactic need to provide a modern analysis of wh-questions in order to show how the interrogative structures can be derived. This study aims to examine the syntax of the wh-question movement in Mehri’s unaccusative/ergative and unergative structures and answer the following questions within Chomsky’s (2000 and 2008) Phase-based Theory: (i) Does the Mehri language allow fronting of wh-phrases to [Spec-CP]? And (ii) how can wh-movement in Mehri unaccusative and (un)ergative structures be accounted for? This work presents a novel analysis of wh-question movement in unaccusative/ergative and unergative structures in Mehri; it demonstrates that the source head C triggers the movement of wh-adjunct and wh-subject phrases. In wh-adjunct extraction, two strategies are employed: overt wh-fronting and wh-in-situ; when the head Foc inherits an edge feature from C, wh-adjunct overtly undergoes movement from its original position within v*P to the left peripheries of [Spec-FocP] and subsequently to [Spec-CP]. When the lexical wh-adjunct remains within v*P, its question features covertly move to [Spec-CP], because the head Foc does not inherit an edge feature from C. In wh-subject extraction, the wh-subject overly undergoes movement to [Spec-CP] because C obligatorily inherits the edge feature to the head Top, which triggers movement of the illogical subject in unaccusative/ergative structures and the logical external specifier in unergative structures to [Spec-CP]. Moreover, Mehri obeys the Phase Impenetrability Condition of Chomsky, where wh-subject and wh-adjunct phrases must pass through certain phases until [Spec-CP].

Learning outcomes The learning outcomes are as follows: decision-making in the areas of business plan, business strategy, financial management, profit planning and marketing, learning from outer business environment, succession planning for first-generation entrepreneur and choosing appropriate source of financing and drivers for diversification. Case overview/synopsis Immersed in sipping green tea in his capacious office lounge, the octogenarian Arjun Mehta introspected on the trials and tribulations of his journey as an entrepreneur, the voyage which started four decades ago. From 1976 to 2018, the business has now traversed three generations. Starting with Spice Mart (Sole Proprietor) to Hindware and Lament Construction (partnership firms) to Starlite Homes Pvt. Ltd. (corporate entity), Mr Mehta witnessed transformation and restructuring in organization with every new generation which characterized the evolution of family business. Handholding children to take up the reins of Spice Mart was not a calculated choice. Yet it is remarkable to study the growth in organizational structure of the regional family business. As a self-made entrepreneur, morals, ethics and value system are vital ingredients steering the organic growth story. Third-generation Mehta’s are enterprising, aspiring and visionary. With the incorporation of a corporate entity, they convinced themselves to bring inorganic growth in their business. Arjun Mehta gleamed with pride as Spice Mart partakes an organized structure which had lost prominence with the second-generation entrepreneurs. But he is equally hammered with juxtaposed thoughts. He contemplates whether the integration of retail business with real estate corroborates sustainable innovation. Will independent businesses create the brand’s footprints perpetually? Should the millennial confine business natively or should they grow internationally and become a conglomerate? Complexity academic level The case can be exclusively taught to masters and executive education class of students pursuing entrepreneurship and business management courses. The case will supplement understanding of theories of entrepreneurship and dimensions of family businesses in emerging economies. Supplementary materials Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes. Subject code CSS 3: Entrepreneurship.

Suketu Mehta is one of the most prolific writers of non-fiction writings emigrated to Newyork from Mumbai along with his family at the age of 14. In the year 1998 he returns to Mumbai and recaptures the maximity of it through various interviews of the local inhabitants and the emigrants from the country. Mehta encompasses these interviews in his narrative non-fictional book, Maximum City: Bombay Lost and Found. This insider outsider perspective of Mumbai resembles with Dante’s Inferno. This research paper basically aims at Mehta’s portrayal of the megacity Mumbai along with the dichotomy of individualism and collectivism. It analyses how the city reciprocates with its inhabitants. It also takes in to account that how this metropolis, despite all its scarcity, is a center of attraction for people across the country to upgrade their living and working status. The way the city caters all its residents, bring forth the juxtaposition of individualism and collectivism.

This paper aims to investigate the languages used in various domains (different settings) in the southern society of Oman and explores the possibility to what extent these languages will be preserved in the future. A number of 40 people from different age groups from the southern Omani society were involved in this study who speak Arabic, Jibbali, and Mehri. Through using a questionnaire and following a thematic analysis, the findings revealed that found both Jibbali and Mehri are used in informal domains within most age groups. Some younger participants were found to already be shifting their language use towards Arabic, even with their family and friends, which is an indication of a gradual shift from these minority languages to Arabic in the southern community which are unlikely to be maintained. Based on these findings, it is recommended that the Omani government take proactive actions to protect minority languages in Oman as encouraging and enabling their use in classrooms, as well as by creating linguistic corpora of these languages that can be used as learning resources.

Snezana Mladenovic Drinic, Editor of the journal Genetika request that it is necessary write exactly family name of the Corresponding author POPULATION DIFFERENTIATION AND GENE FLOW IN Erodium cicutarium: A POTENTIAL MEDICINAL PLANT by Yaocheng JIA*1, Majid KHAYYATNEZHAD2, Shahram MEHRI3 1University of Yuncheng, Department of arts and crafts design, Yuncheng, Shanxi, 044000 2Young Researchers Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran. 3Department of Agronomy and Plant Breeding, ParsAbad Moghan Branch, Islamic Azad University, ParsAbad Moghan, Iran Original scientific paper https://doi.org/10.2298/GENSR2003127J published in the journal Genetika, 2020, Vol 52, No.3, 1127-1144 since due to typing error family name of the Corresponding author Majid KHAYATNEZHAD has not been correctly written, as: Majid KHAYYATNEZHAD But in has to be written as: Majid KHAYATNEZHAD <br><br><font color="red"><b> Link to the corrected article <u><a href="http://dx.doi.org/10.2298/GENSR2003127J">10.2298/GENSR2003127J</a></b></u>

Abstract The tumor ascites environment is enriched with cytokines and growth factors especially members of the Transforming Growth Factor-β (TGF-β) family, that play crucial roles in modulating anoikis sensitivity and consequently metastatic progression in ovarian cancer. Here, we demonstrated for the first-time significant broad dichotomy between these TGF-β members: BMPs and TGF-β/activin and their regulated SMADs in this process. We previously reported BMP9/GDF2 to be in low to undetected levels in ovarian cancer patient-derived ascites and promoted anoikis resistance in both breast and ovarian cancer cell lines. We have now identified additional BMPs -BMP2, BMP4 and BMP9 as promoting anoikis sensitivity in a spectrum of ovarian cancer cells. Conversely, we found TGF-βs (1 and 2) to be in much higher expression and demonstrated that TGF-β and activin promoted anoikis resistance in ovarian cancer. Hence, in an attempt to identify genes downstream of BMPs that may provide anoikis resistance, transcriptomics was performed leading to the identification of Sox2, a developmental gene with prior established roles in OVCA, as being significantly downregulated in response to BMP9. We further uncovered Sox2 to be reciprocally regulated by anoikis-promoting BMPs (2, 4 and 9) and anoikis suppressing TGF-β and activin A. Our findings highlight a novel contrasting SMAD dependent regulation of Sox2 as a central node for controlling tumor cell survival in ovarian cancers demonstrating a subset of BMPs as a therapeutic strategy in cancer. The studies presented here begin to elucidate the mechanisms of reciprocal epigenetic regulation of Sox2 by BMP and TGF-β/activin in the context of ovarian cancer, which is the most lethal gynecologic malignancy in women due to peritoneal metastatic spread. Citation Format: Zainab M. Shonibare, Mehri Monavarian, Kathleen O'Connell, Diego Altamore, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Andrew Berchuck, Andrew B. Nixon, Rebecca Arend, Nam Y. Lee, Ryan Miller, Nadine Hempel, Karthikeyan Mythreye. Reciprocal Sox2 regulation by SMAD1 and SMAD3 is critical for anoikis resistance and metastasis in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 107.

This article proposes a reading of Mehdi Charef’s Le Harki de Meriem [‘Meriem’s Harki’] (1989) and its 2016 edition that focuses on the text’s discursive and paratextual practices employed to represent Franco-Algerian historical and cultural heritage. This non-linear narrative presents a family saga over the course of the twentieth century, revealing in the process key episodes of the mutual and turbulent history of colonial Algeria and postcolonial France. Through a discussion of passages and editorial work that relate the novel with historical events, I will trace patterns of critique that emphasize their concern with history as a source of knowledge. Such a dialectical analysis will in turn provide a reading paradigm that paves the way into a hybrid France that fragments both the French national grand narrative and Franco-Algerian memory.

Recent portrayals of trans-Mediterranean mobility within French and Maghrebi francophone queer cinema have showcased the return of immigrant and second-generation queer men of Maghrebi origin to their diasporic homeland in North Africa. Focusing on two films from this corpus – Rémi Lange’s 2001 Tarik El Hob (The Road to Love) and Mehdi Ben Attia’s 2009 Le fil (The String) — this article traces the ways in which ethnic queer subjects have fostered alternative genealogies of kinship and intimacy in relation to the French nation state and the Maghrebi heteronormative family. It demonstrates how such a reconceptualization of kinship ties involves the renegotiation of domesticity for queer Maghrebi immigrant and diasporic subjects against the backdrop of institutional kinship structures such as civil unions and same-sex marriage in contemporary France.

The aim of this study is to investigate the role of Iranian traditional needlework in people's family and social life with an emphasis on the art of Pateh embroidery. In this article, the history of textile industry, the history of clothes, different sewing styles and how they have been influenced by each other, are studied. According to the "History of Iranian Textile Industry", a book written by Mehdi Beheshtipour, textile industry in Iran dates back to 7000 years ago.Tabari book of history states that this industry goes back to 4000 years ago. Excavations in Shoosh show that burlap weaving, silk weaving and embroidery were forms of art at the time of JamsheedPishdadi. Herodotus says that Xerxes wore embroidered clothes. Marco Polo refers to the art of Kerman's Pateh embroidery in his travelogue. Qajar era is called the renaissance of Iranian needlework. Different styles of needlework have been investigated in previous practical studies with reference to the regionswhere they are common and how they are used. Pateh embroidery is considered as a traditional art in Kerman. This form of needlework has been paid attention to since 1906 from economic, social and cultural perspectives and studied as a profession that can meet people's financial and aesthetic needs.

AimBullying is a significant problem among school children and within the climate and culture of many schools. Research has indicated that environmental and psychosocial factors may play an important role in the culture change needed to minimise bullying behaviours in schools (Goldweber et al., 2013; Mehta et al., 2013; Sapouna & Wolke, 2013). A growing body of literature suggests that belonging, one such type of psychosocial factor may act as a buffer for bullying perpetration. For this reason, the current study aimed to explore the relationship between peer, family, and school belonging and bullying behaviours.Method/RationaleStudents from rural middle schools (ages 11–14; N=912) in the United States completed surveys including questionnaires on bullying and peer, family, and school belonging. Structural equation modeling was used to examine the relationship between belonging and bullying behaviour.FindingsThe results support the hypotheses and suggest there is a link between sense of belonging (peer, family, and school) and bullying behaviour.LimitationsThe most notable limitation is that the data are cross-sectional, examining the variables at one particular time point, which eliminates the possibility of studying longitudinal impact. Further, all measured constructs examined were done through self-report assessments. Thus, observational and behavioural information was not collected or utilised in the current study.ConclusionsThese findings have an important applied component and could lead to stronger intervention efforts. Specifically, interventions that focus on increasing positive peer-level interactions, coupled with a stronger sense of school community or belonging, could result in decreases in bullying behaviours.

The paper aims at exploring the female protagonist, Radhika Mehta, of One Indian Girl by Chetan Bhagat in the light of the ideals of the New Woman in Indian context. This is an ideal which had emerged in the late 19th century and has had a profound influence to date. It associates women as independent, physically adept and mentally acute, and able to work, study, and socialize equal to men. Having been exposed to many Western countries during her career, Radhika focuses on her status and career, earns more than boys normally does, involves in premarital sex, and shows her individuality. However, she cannot renegotiate the traditional roles altogether. Rather, she tries to evade a critique of power relations within the family and attempt to get the best of both worlds, concretizing existing gender roles and taking on additional new ones.

In December 1977 an independent candidate named Mehdi Zana was elected mayor of Diyarbakır, one of the biggest cities in Turkey's southeastern region. His election was a striking event, upsetting the troika of class, party, and state that had maintained a tight hold over the local political apparatus in Diyarbakır since the 1940s. Unlike most prior mayors of Diyarbakır, Zana did not come from a prominent family of local notables but was a working-class tailor with a middle-school education. He was one of only two independent candidates who won electoral contests in Turkey's sixty-seven big-city races; his election therefore flew in the face of a national trend that favored candidates from the country's two main political parties. Zana was well known for his left-wing, Kurdist politics, and at the time of his election he already had spent several years in jail for his activism. In a system that suppressed collective expressions of Kurdish identity, he was thus a clear ideological interloper.

We introduce and study a family of random processes with a discrete time related to products of random matrices. Such processes are formed by singular values of random matrix products, and the number of factors in a random matrix product plays a role of a discrete time. We consider in detail the case when the (squared) singular values of the initial random matrix form a polynomial ensemble, and the initial random matrix is multiplied by standard complex Gaussian matrices. In this case, we show that the random process is a discrete-time determinantal point process. For three special cases (the case when the initial random matrix is a standard complex Gaussian matrix, the case when it is a truncated unitary matrix, or the case when it is a standard complex Gaussian matrix with a source) we compute the dynamical correlation functions explicitly, and find the hard edge scaling limits of the correlation kernels. The proofs rely on the Eynard–Mehta theorem, and on contour integral representations for the correlation kernels suitable for an asymptotic analysis.

AbstractNew data about the fauna of nematodes of Baruscapillaria genus have been obtained which show that they parasitize domestic geese in the Poltava region of the Ukraine. It has been established that the species composition of Capillariidae is represented by two species—B. anseris (Madsen, 1945, Moravec, 1982) and B. obsignata (Madsen, 1945, Moravec, 1982). For the first time in the Ukraine, parasitisation with non-specific geese species of Capillariidae family, B. obsignata, have been substantiated. It was found that capillariosis of geese was more frequent in the co-invasions of the birds’ digestive channel; the prevalence of invasion was 41.97 %. According to the results of helminthological dissection and identification of isolated pathogens, 40 varieties of co-invasions were found, where nematodes of the Baruscapillaria genus were combined with cestodes of two species: Drepanidotaenia lanceolata (Bloch, 1782) and Tschertkovilepis setigera (Froehlich, 1789), as well as with nematodes of four other species: Аmidostomum anseris (Zeder, 1800), Trichostrongylus tenuis (Mehlis, 1846), Heterakis gallinarum (Schrank, 1788) and Heterakis dispar (Schrank, 1790). Most often, we recorded capillariosis as a part of two- (prevalence—17.75 %) and three-component (11.75 %) co-invasions, and the main coexisting helminths of Capillariidae from Baruscapillaria genus were nematodes A. anseris (prevalence 22.78 %) and H. dispar (14.15 %).

<p>Arabic is the first widely used language in Oman. It is not uncommon, however, to come across Omanis who converse in minority languages other than Arabic. Remarkably, these languages are of three different families: Indo-Iranian languages such as Kumzari, Lawati, Zadjali, Baluchi; Modern South Arabian languages such as Harsusi, Bathari, Hobyot, Mehri, and Jabbali /Shehri; and Bantu language family which includes Swahili. Named after the ethnic groups speaking them as mother tongues side by side with Arabic, the number of speakers of these languages varies as some are spoken by thousands of speakers while other languages may claim only a few hundred speakers. Academic work geared towards exploring these languages is scarce indeed, especially languages such as Kumzari, Harsusi, Zadjali, Bathari and Hobyot, a fact that makes them lesser-known and uninvestigated as opposed to their counterparts. In view of this, the focus of this paper lies on one of the lesser-known and unexplored minority languages spoken in Oman, namely Kumzari. In line with this, the study highlights the genetic affiliation of Kumzari, its speakers and their location, views on the origin of its name and its future status.</p>

The process of the settlement Sulice modern Bosniak families origin and development is possible to observe, based on the available historical sources, only in 19th century. The main data sources were the male population census of Kaza Srebrenica from 1850/51, and the first entries of owners in land registers of Srebrenica district in 1894. By comparing the data from the sources above, as well as from the population census of 1991, it was possible to establish continuity of settlement and development of Sulice families in this part of Srebrenica municipality. In the Sulice population census from 1850/51 the following last names are mentioned: Behramović, Bejan, Bejanović, Haskić, Hodžić, Huremović, Kandžetović, Kumović, Smajić, Spahić and Šulić. By the first entries in land registers of 1894 for the cadastral municipality of Sulice a large number of last names is stated, the most common of which are: Abdurahmanović (Hadžihafizbegović), Ademović, Aljkanović, Avdić, Bajramović, Beganović, Begić, Begović, Bektić, Burić, Bumbulović, Čivić (Rešić), Delić, Dudić, Džananović, Džanić, Džinović, Efendić, Fočak, Fržina, Gurda, Gurdić, Halilbašić, Hasanović, Hasić, Haskić, Hodžić, Huseinović, Husić, Ibišević, Ibrahimović, Idrizović, Imširović, Jahić (Kadrić), Junuzagić, Kadrić, Kajmaković, Kovačević, Kuleša, Lemeš, Lolić, Mahmutović, Mandžić, Mašić, Mehić, Mehmedović, Mehmedović (Silajdžić), Mehanović, Meholjić (Mehanović), Mešić, Mostarac (Dženetić), Muhić (Mujić), Musić, Mustafić, Nuhanović, Nukić, Nukić (Begović), Okanović, Omerović, Osmanović (Kavazović), Osmanović (Selimović), Palalić, Pašagić, Pinjić (Čikarić), Pitarević, Prijepoljac, Ramić, Rustanbegović, Salihović, Selmanagić, Selimović, Siručić (Salihović), Smajlović, Suljić, Sumbulović, Šarvan, Šećić, Šehić, Šolić (Šulić), Špijodić, Tanković, Tepić, Ustić, Uzunović, Vranjkovina, Zildžić, Zimić, Zulo (Agičević). Only those families who lived in the Sulice settlement in the second half of the 19th century have been researched in this paper. Those are the following families: Abdurahmanovićs (Hadžihafizbegović), Alićs, Aljkanovićs, Avdićs, Bajramovićs (Behramović), Begovićs, Bejans, Bejanovićs, Bektićs, Burićs, Džinovićs, Haskićs, Hodžićs, Huseinovićs, Imširovićs, Kadrićs, Kandžetovićs, Kulešas, Mehanovićs (Kandžetović), Mujkićs, Musićs, Mustafićs (Dervanović), Mustafićs (Spahić), Nuhanovićs, Nukićs, Osmanovićs (Selimović), Pejmanovićs, Sahadžićs, Selimovićs (Huremović), Selimovićs (Kumović), Smajlovićs, Suljićs (Smajić), Šarvans, Šolićs and Špijodićs. Most male members who had been listed in 1850/51 census in the Sulice settlement had their descendants, either male or female, who continued their family, i.e. genetic lineage, thus preserving their family and genetic heritage. Some families, such as Alićs, Abdurahmanovićs, Haskićs, Kadrićs, Kandžetovićs, Mehanovićs, Nuhanovićs, Selimovićs, etc. were more numerous than others, due to either greater natural increase or less emigration outside the Sulice settlement. However, it was not possible to research the impact of migration on the overall Sulice population growth because it was not a part of the official policy of neither Ottoman nor Austro-Hungarian Empire. On the contrary, the Austro-Hungarian Monarchy made an effort to minimize the extent of Muslim emigration from Bosnia and Herzegovina in the period from 1879 to 1918 because this did not work in its favour considering the commitments it had made during the Berlin Congress in 1878. It is important to note that most male members of the Sulice settlement families, who had been listed in 1850/51 census, took their family name (last name) at the end of the 19th century or at the beginning of the 20th century because it was mandatory during the Austro-Hungarian occupation of Bosnia and Herzegovina, while during the Ottoman Empire rule it was not. The phenomenon of formation of family names (last names) for the wider area of the Osat region was not specifically researched, thus not in this paper either, because the topic of this paper has been to research the process of formation of the individual families in the Sulice settlement in the second half of the 19th century. Based on this this process it is possible to notice that most families, who have a common ancestor, kept their common family name, i.e. last name.

Abstract Abstract 1730 Poster Board I-756 The sonic hedgehog (SHH) pathway, associated with proliferative stem cell niches of many organs, is frequently deregulated in diverse cancers. We have previously shown that the SHH pathway augments the survival of tumor cells by inducing antiapoptotic molecules including bcl-2 and provides resistance to a number of conventional cancer therapies. Aberrant activation of the SHH pathway has been associated with activation and maintenance of lymphoid malignancies. Additionally, our recent data indicates that p63, a p53 family member and an important marker of stem cells has multiple interacting nodes with the SHH pathway. Based on these observations, we hypothesized i) that there is crosstalk between the SHH and p53/p63 networks in cells and, ii) inhibition of the SHH pathway with simultaneous activation of the p53 pathway would result in increased cell death in cancer cell lines of lymphoid origin. Using SDS-PAGE followed by immunoblotting and RT-PCR we surveyed a panel of 18 leukemia/lymphoma cell lines for components of the SHH pathway and the p53/p63/p73 network. Robust SHH pathway expression was observed in 15 of the 18 cell lines examined. Interestingly, in p53 deficient cell lines there was an increase in p63/p73 expression as compared to cell lines with wild type (WT) p53. A set of the previously analyzed diffuse large B- cell lymphoma (DLBCL) cell lines were selected and were representative of both p53 deficient and WT cell lines and also the activated B-like DLBCL (ABC) and germinal center B-like DLBCL (GCB) subgroups. These cells were treated with cyclopamine, an inhibitor of the SHH pathway and/or nutlin, an HDM2 antagonist. Cell viability (MTS assay) was measured using both compounds at various drug concentrations and time points. In addition we also investigated the effects of the drugs individually and in combination on components of the p53/p63 and SHH axes and their targets. Our findings suggest that treatment of p53 (WT) cell lines with a combination of nutlin and cyclopamine results in reduced cell survival than treatment with either drug alone and at lower drug concentrations and that the p53 status of the cell line may be more important in determining therapeutic response to the selected compounds. In addition the p53/p63 pathway may have a novel role in regulation of specific components of the SHH pathway in cells of lymphoid origin. In conclusion, these observations provide proof of concept that a combinatorial therapeutic approach, targeting both the p53 and SHH axes would provide a more robust and favorable response in large B cell lymphomas. Acknowledgments This work was supported in part by the The Mehta Family Foundation Disclosures No relevant conflicts of interest to declare.

Review of European Studies wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated. Review of European Studies is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://recruitment.ccsenet.org and e-mail the completed application form to res@ccsenet.org. Reviewers for Volume 11, Number 1 Alejandra Moreno Alvarez, Universidad de Oviedo, Spain Arthur Becker-Weidman, Center For Family Development, USA Carmen Ramos, University of Oviedo, Spain Dave Williams, Dublin Institute of Technology, Ireland Efstathios Stefos, University of the Aegean, Greece Emilia Salvanou, Hellenic Open University, Greece Gabriela Gruber, Lucian Blaga University of Sibiu, Romania George Touche, Texas A&amp;M University, USA Hyunsook Kang, Stephen F. Austin State University, United States Ifigeneia Vamvakidou, University of Western Macedonia, Greece Ioan-Gheorghe Rotaru, &lsquo;Timotheus&rsquo; Brethren Theological Institute of Bucharest, Romania Ioanna Efstathiou, University of the Aegean, Greece Karen Ferreira-Meyers, University of Swaziland, Swaziland Macleans Mzumara, Bindura University of Science Education, Zimbabwe Maria-Eleni Syrmali, Panteion University, Greece Meenal Tula, University of Hyderabad, India Mehdi Ghasemi, University of Turku, Finland Mirosław Kowalski, University of Zielona G&oacute;ra, Poland Nikos Christofis, Shaanxi Normal University, Greece Rebecca Burwell, Westfield State University, USA Rickey Ray, Northeast State Community College, USA Ronald James Scott, Leading-Edge Research Institute, USA Savanam Chandra Sekhar, St. Ann&rsquo;s College of Engineering &amp; Technology, Chirala, India Serena Kelly, University of Canterbury, New Zealand Smita M. Patil, School of Gender and Development Studies, India Szabolcs Blazsek, Universidad Francisco Marroquin, Guatemala

11007 Background: The HER-2/neu oncoprotein is a transmembrane tyrosine kinase that belongs to the family of epidermal growth factor receptors. It is known to be overexpressed in 20–40% of breast cancers. Increased serum HER-2/neu (sHER-2/neu) concentrations at the beginning of adjuvant breast cancer therapy have been shown to be of prognostic importance (Mehta et al, 1998). Using the sera from the Takeda® Adjuvant Breast Cancer Study with Leuprorelin (TABLE study), we tested for the prognostic value of sHER-2/neu. Methods: A total of 133 premenopausal, node-positive, hormone-receptor positive patients received either 11.25 mg of leuprorelin s.c. every 3 months over 2 years or CMF chemotherapy for 6 cycles. Blood samples were collected at baseline and at 3, 6, 12, 18, 24 and 30 mo. The primary endpoint of the study was to determine the relapse-free survival (RFS) after 2 years. sHER-2/neu was measured using a standardized ELISA (upper limit of normal 15 ng/ml). As the baseline sHER-2/neu concentrations ranged from 3.8–14.0 ng/ml, results were grouped in terciles. Data were analyzed using Kaplan-Meier and Cox Proportional Hazards survival analysis. Results: Material was available from 80 patients in leuprorelin arm and 53 patients in CMF arm. 65 of 133 patients had relapsed during the follow-up time of up 7 years after treatment. The median RFS was 62.9 mo. The RFS time depended on the concentrations of sHER-2/neu at baseline: RFS was significantly shorter in patients of the third tercile with sHER-2/neu levels >8.8 ng/ml than in patients of the first tercile with levels <7.2 ng/ml (p=0.0232). Five years after initial therapy, we found that 73% of patients in the first tercile group of baseline sHER-2/neu had no relapse. In the second tercile, 63.3% of patients were relapse-free, while in the third tercile only 47.2% of patients had not suffered from a relapse. Conclusions: Higher sHER-2/neu concentrations at the beginning of adjuvant therapy in the TABLE-Study have a prognostic importance for RFS. This observation was evaluated irrespective of the HER-2/neu tissue status and could be of clinically importance for adjuvant therapy with the monoclonal anti-HER-2/neu antibody trastuzumab or other anti-HER-2/neu targeted therapies. No significant financial relationships to disclose.

Abstract Background Current mitigation strategies for SARS-CoV-2 rely on population-wide adoption of non-pharmaceutical interventions (NPIs). Monitoring NPI adoption, mobility patterns and their association with SARS-CoV-2 infection can provide key information for public health agencies and be used to calibrate transmission models. Methods We used an online panel to accrue representative samples from Florida, Illinois, and Maryland (n=3,009, approximately 1,000 per state) from July 15–31, 2020 and capture socio-demographically and geographically resolved information about NPI adoption and mobility in the prior 2 weeks. Logistic regression was used to identify correlates of self-reported SARS-CoV-2 infection in the prior 2 weeks. Results Overall, 96% reported traveling outside their home in the prior 2 weeks, the most common reason being to visit a grocery store/pharmacy (92%), followed by visiting friends/family (61%), and visiting a place of worship (23%); 22% reporting public transportation use. In total, 44% of respondents reported always practicing social distancing and 40% reported always using a mask indoors and outdoors. Overall, 74 (2.5%) reported testing positive for SARS-CoV-2 in the prior 2 weeks, with strong dose-response relationships between several forms of movement frequency and SARS-CoV-2 positivity. Variables capturing mobility were all highly correlated with one another, suggesting there are clusters of individuals who engage in multiple activities (Figure); 41% of positive cases engaged in all forms of mobility captured compared to 1% of those who did not test positive within the prior 2 weeks. Patterns of mobility and NPI uptake did not significantly differ by state; however, there were significant relationships with age, race/ethnicity, and gender. In multivariable models including adjustment for NPIs, significant relationships remained with public transportation, visiting a place of worship, and participating in outdoor group fitness activities. Figure. Heatmap depicting pairwise Spearman correlation coefficients between survey responses. Pairwise correlation coefficients are displayed in the boxes at intersection of any two variables. Questions were asked with respect activities in the prior 2 weeks. Conclusion NPI adoption and mobility did not vary across these three states with variable policies and SARS-CoV-2 positivity rates. Rather, associations with recent positivity appear to be driven largely by mobility patterns and engagement in activities where NPI use may be challenging or inconsistent. Disclosures Shruti Mehta, PhD, MPH, Gilead Sciences (Other Financial or Material Support, Speaker) Sunil Solomon, MD, PhD, MPH, Abbott Diagnostics (Grant/Research Support)Gilead Sciences (Grant/Research Support, Advisor or Review Panel member)

BackgroundWith total hip arthroplasty (THA) utilization rising rapidly,[1]it is important to understand social determinants of health (SDOH) that contribute to disparities in THA outcomes.ObjectivesWe sought to explore the relationship of multiple community-level SDOH with 90-day readmission, 90-day mortality, 1-year revision post-THA, and length of stay (LOS) using prediction modelling.MethodsOur retrospective study using the Pennsylvania Health Care Cost Containment Council Database included 105,336 patients undergoing THA 2012-2018. Community-level variables include walkability index; median household income; and percent unpaid family workers, without health insurance and not in the labor force, above high school, above college, foreign-born, speaking languages other than English, with computer access, and with internet access. They were extracted from US census via geocoding. We trained explainable boosting machine using Generalized additive models to predict readmission, mortality, LOS, and revision. Resulting mean absolute scores (MAS) were aggregated to measure collective importance of the above “community-factors.”ResultsPredictive performance was best for mortality (AUROC=0.76); it was moderate for readmission (AUROC=0.66), revision (AUROC=0.58), and LOS (RMSE=0.41, R2=0.2). Community factors relatively contributed more to adverse outcomes than race in all models. The top 3 predictors of readmission were discharge location, age, and comorbidities (MAS =0.24, 0.15, 0.13, respectively). The top 3 predictors of mortality were community factors, discharge location, and age (MAS=0.31, 0.24, 0.19, respectively). The top 3 predictors of revision were community factors, discharge location, and comorbidities (MAS=0.03, 0.01, 0.005, respectively). Lastly, the top 3 predictors for LOS were discharge location, community factors, and comorbidities.ConclusionIn all THA outcome models, aggregated community factors were more important than individual race in predicting 90-day readmission, 90-day mortality, 1-year revision, and length of stay.Reference[1]Wolford ML, Palso K, Bercovitz A. Hospitalization for total hip replacement among inpatients aged 45 and over: United States, 2000-2010.NCHS Data Brief. 2015;(186):1-8.“Community” is the aggregate importance score for % householder living alone, % foreign born, % speaking language other than English, % with computer access, % with internet access, national walkability index, % not in labor force without insurance, % above high school, % above college, % with unpaid family workers, and median household income, extracted from American Community Survey or calculated by the National Walkability Index software from patient zip code.Table 1.Patient-level characteristics by outcomeOutcome90-day readmission90-day mortalityRevisionNoN = 96914YesN = 8422pNoN = 105027YesN=309pNoN = 103719YesN = 1617pAge65.0 [58.0; 73.0]69.0 [60.0; 77.0]****65.0 [58.0; 73.0]77.0 [67.0; 84.0]****65.0 [58.0; 73.0]65.0 [58.0;74.0]NSSex******Female52330 (54.0%)4647 (55.2%)56826 (54.1%)151 (48.9%)56046 (54.0%)931 (57.6%)Male44584 (46.0%)3775 (44.8%)48201 (45.9%)158 (51.1%)47673 (46.0%)686 (42.4%)Race****NSNSBlack6262 (6.47%)692 (8.22%)6936 (6.60%)18 (5.83%)6835 (6.59%)119 (7.36%)Other2956 (3.05%)186 (2.21%)3135 (2.98%)7 (2.27%)3108 (3.00%)34 (2.10%)White87619 (90.5%)7539 (89.5%)94874 (90.4%)284 (91.9%)93695 (90.4%)1463 (90.5%)Missing775820811Length of stay2.00 [1.00; 3.00]3.00 [2.00; 3.00]****2.00 [1.00; 3.00]3.00 [2.00; 4.00]****2.00 [1.00;3.00]2.00 [2.00;3.00]****Elixhauser comorbidity index************>54797 (4.95%)1078 (12.8%)5792 (5.51%)83 (26.9%)5751 (5.54%)124 (7.67%)016952 (17.5%)714 (8.48%)17647 (16.8%)19 (6.15%)17488 (16.9%)178 (11.0%)1-475165 (77.6%)6630 (78.7%)81588 (77.7%)207 (67.0%)80480 (77.6%)1315 (81.3%)Categorical variables N(%), continuous variables median[IQR].**** p < 0.001; *** p < 0.01; ** p < 0.05; * p < 0.1; NS = nonsignificantAcknowledgements:NIL.Disclosure of InterestsBella Mehta Consultant of: Novartis education content development, Yi Yuan: None declared, Diyu Pearce-Fisher: None declared, Kaylee Ho: None declared, Susan Goodman Consultant of: Paid consultant for UCB., Grant/research support from: Research support from Novartis., Michael Parks: None declared, Fei Wang: None declared, Mark Fontana: None declared, Said Ibrahim: None declared, Peter Cram: None declared, Rich Caruna: None declared.

Abstract 4-1BB is a co-stimulatory TNF receptor family member upregulated on activated T cells, where it supports proliferation and enhanced functionality. 4-1BB agonizing monoclonal antibodies have thus far failed to progress beyond early clinical development, either due to hepatic toxicities caused by FcγR-crosslinking (urelumab) or due to low clinical activity (utomilumab). An attractive next-generation approach to 4-1BB agonistic therapeutics are multi-functional biologics that conditionally activate 4-1BB only in the tumor microenvironment, thereby localizing activity and minimizing toxicity. Furthermore, there is a strong rationale to combine 4-1BB agonism with checkpoint inhibition. Opal is a novel multi-specific construct that, in a single molecule, combines (i) a single-chain, trimeric 4-1BB ligand (sc4-1BBL); (ii) an engineered variant of the PD1 extracellular domain (ECD) with affinity-enhancing mutations (mutPD1); and (iii) a serum half-life extension domain. By fusing sc4-1BBL and mutPD1, 4-1BB agonism became conditional on the presence of PDL1 or PDL2. By using the mutPD1 ECD rather than an anti-PDL1 antibody, the specificity of Opal is expanded to PDL2-expressing cancer cells with low to undetectable levels of PDL1. The use of trimeric 4-1BBL is expected to optimally agonize the 4-1BB receptor by engaging its natural binding site. Opal omits a functional Fc gamma domain to avoid the hepatic toxicities associated with urelumab. Opal properties were characterized using biophysical and cellular assays. We showed by surface plasmon resonance spectroscopy that compared to wildtype (wt) PD1, mutPD1 had affinities for PDL1 and PDL2 that were enhanced by &gt;2000-fold and &gt;200-fold, respectively. In a competition ELISA assay, Opal effectively blocked wt PD1 from binding to PDL1 and PDL2. PDL1/2-conditional activation of 4-1BB was shown in two independent assays. First, using 4-1BB reporter cells, 4-1BB activity was enhanced &gt;5x when Opal was pre-complexed with recombinant PDL1-Fc. Second, when activated PBMCs were co-cultured in the presence of HEK293T-PDL1 or -PDL2 cells with serial dilutions of Opal, induction of IFNγ secretion was detectable only in the presence of PDL1 or PDL2. Importantly, variants of Opal with abrogated PD1 or 4-1BBL domains failed to trigger IFNγ production. To evaluate the efficacy and toxicity of Opal in vivo, MC38 tumor cells expressing human PDL1 were inoculated in the flanks of mice expressing human 4-1BB. When tumor-bearing mice were treated IP with Opal at 1 mg/kg, 7/10 mice exhibited durable cures without significant body weight loss. Taken together, the preclinical data suggests that Opal may exhibit single-agent activity in solid tumors by conditionally activating effector cells in the tumor microenvironment via 4-1BB agonism while concurrently blocking the PD1/PDL1/PDL2 axis. Citation Format: Naveen K. Mehta, Bochong Li, Patrick A. Baeuerle, Jennifer S. Michaelson. Opal is a conditional 4-1BB agonistic fusion protein comprising trimerized 4-1BB ligand and a high affinity variant of the extracellular domain of PD-1 [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2076.

Abstract Introduction: CFT7455 is a highly potent and novel Ikaros Family Zinc Finger Protein 1/3 (IKZF1/3) degrader. In xenograft models, CFT7455 has more potent IKZF1/3 degradation compared to other degraders. Early observations from the FIH clinical trial (NCT04756726) along with supporting translational studies are presented here. Methods: Pre-clinical studies comparing CFT7455 and CC-92480 in both in vitro and xenograft models were performed. The pre-clinical studies’ results coincided with observations from the on-going clinical trial. The clinical trial is an open-label, Phase 1/2, multi-center, FIH study in heavily pretreated relapsed/refractory (R/R) MM and non-Hodgkin’s lymphoma (NHL) patients evaluating safety, tolerability, and PK of CFT7455. Eligible MM patients are R/R to therapy and are not candidates for regimens known to provide clinical benefit. A starting dose of 50 μg QD 21 days on/7 days off (21/7) in 28-day cycles was administered. Results: CFT7455 and CC-92480 showed similar cereblon binding profiles and in vitro IKZF1/3 degradation kinetics, translating into sub-nanomolar GI50 values in proliferation assays across a panel of MM cell lines. In the NCI-H929 xenograft model, 100 μg/kg/day of CFT7455 resulted in durable tumor regressions, while 1000 μg/kg/day of CC-92480 gave tumor stasis. Similar results were seen in a systemic model of MM, MM1.S. Both compounds achieved &gt;95% IKZF3 degradation in tumors 4h post dose. At 48h post dose, CFT7455 was more effective than CC-92480 in maintaining IKZF3 degradation (65% vs. 6% respectively). When levels of CFT7455 and CC-92480 in plasma and tumor were compared, CFT7455 concentrations were &gt; DC80 in tumor 48h post dose, while CC-92480 levels were undetectable in tumor and plasma, demonstrating CFT7455 has longer exposure resulting in sustained IKZF1/3 degradation in pre-clinical models. In cohort A, 5 heavily pre-treated MM patients (pts) received single agent CFT7455. 4 pts have received at least 3 cycles, with 2 pts receiving 5 cycles. Neutropenia (grade 4) was observed in 3/5 pts without coincident fever or infection. Additionally, a 2-4 fold accumulation in plasma CFT7455 exposure at steady state was observed. Early pharmacodynamic (PD) data demonstrates deep persistent degradation of IKZF3 (~100%) and serum free light chain reduction (up to 72%) in response to treatment. Stable disease has been observed in 34 pts, suggesting clinical benefit. Conclusions: While CFT7455 showed clinical benefit at 50 ug with deep target degradation, neutropenia was dose limiting. PK/PD modeling suggests alternative dosing regimens may result in increased tolerability with preserved efficacy, and evaluation of them is underway. Updated results will be presented at the meeting. Citation Format: Sagar Lonial, Shambavi Richard, Jeffrey V Matous, Andrew J. Yee, Urvi Shah, Neha Mehta-Shah, Thomas Martin, Eli Muchtar, Sikander Ailawadhi, Paul G. Richardson, Manisha Bhutani, Samantha Perino, Jason Kirby, Roman V. Agafonov, Prasoon Chaturvedi, Bradley Class, Matthew Schnaderbeck, Michael R. Palmer, Cathleen Gorman, Oliver Schoenborn-Kellenberger, Amanda Hoerres, Stewart L. Fisher, Roy M. Pollock, Adam Crystal, Michelle Mahler, Jesus Bardeja. Pharmacokinetic (PK) profile of a novel IKZF1/3 degrader, CFT7455, enables significant potency advantage over other IKZF1/3 degraders in models of multiple myeloma (MM) and the results of the initial treatment cohort from a first-in-human (FIH) phase 1/2 study of CFT7455 in MM [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT186.

Prussian Blue (PB) and its analogues (PBAs) are a large family of transition metal hexacyanoferrates with general formula of AxM[Fe(CN)6]γ□1-γ∙zH2O. They have open framework structure, redox-active sites and strong structural stability, which makes them perspective electrode materials, as PBAs are able to perform the rapid insertion and extraction of the ions with the lowest possible lattice strain. In addition, they are safe, non-toxic and relatively inexpensive. Among simple PBAs, manganese hexacyanoferrate (MnHCF) displays a high specific capacity and redox plateaus at a high voltage against lithium and sodium in LIBs and SIBs [1]. The synthesis of MnHCF is possible by simple co-precipitation method. In our group we synthesized and investigated its structure and electrochemical performance as a cathode material. For the characterization of MnHCF several conventional and synchrotron-based techniques were used. Generally, after cycling inside the battery some changes might occur in the cathode material, including changing the charge states of the different elements. For the investigation of this phenomenon synchrotron techniques are particularly informative, such as energy-dependent full field transmission soft X-ray microscopy (TXM), which is able to give a full picture at the nanometre scale of the chemical state and spatial distribution of the elements [2]. By using X‐rays in the “soft” energy region (<3 KeV), it is possible to access transitions from the core levels of the light elements, such as the K‐edge of nitrogen, oxygen, fluorine, as well as L- and M- edges of heavier elements [3, 4]. TXM provides pixel-by-pixel absorption spectrum, making it possible to select groups of pixels and map regions with the similar spectral features [2]. Therefore, TXM studies were conducted on our material before and after cycling, and the special protocol of the data treatment was developed and applied to the results of the analysis in order to enhance the representation of the heterogeneities, if any, and then to extract the most relevant spectra. Indeed, the inhomogeneities within the samples were identified, especially in the aged electrodes. It was observed that the distribution of the heterogeneities were different for the electrodes extracted from the Li-ion system, compared to Na. Characteristic spectra from the entire samples as well as particular regions with different oxidation states were obtained and compared to one another, which made it evident, that the treated results from the iron L-edge and manganese L-edge expressed strong correlation, however, while in the Fe K-edge the distribution of heterogeneities looked quite random, a weak bulk-border effect was observed in case of the Mn K-edge. [1] A. Mullaliu, J. Asenbauer, G. Aquilanti, S. Passerini, M. Giorgetti, Small Methods 4, (2019) 1900529. [2] A. Sorrentino, L. Simonelli, A. Kazzazi, N. Laszczynski, A. Birrozzi, A. Mullaliu, E. Pereiro, S. Passerini, M. Giorgetti, D. Tonti, Appl. Sci., no. 11, p. 2791, 2021. [3] D. Tonti, M. Olivares-Marín, A. Sorrentino, E. Pereiro, L. P. Mehdi Khodaei, Ed., IntechOpen, 22 March, 2017.[1] A. Mullaliu, J. Asenbauer, G. Aquilanti, S. Passerini, M. Giorgetti, Small Methods 4, (2019) 1900529.[2] A. Sorrentino, L. Simonelli, A. Kazzazi, N. Laszczynski, A. Birrozzi, A. Mullaliu, E. Pereiro, S. Passerini, M. Giorgetti, D. Tonti, Appl. Sci., no. 11, p. 2791, 2021. [4] D. Attwood, Cambridge: Cambridge University Press, 1999. Figure 1

BackgroundSGN-B7H4V is a novel, investigational vedotin antibody drug conjugate (ADC) directed to B7-H4, a member of the B7 family of immune checkpoint ligands. B7-H4 expression is elevated on a variety of solid tumors including breast, ovarian, and endometrial tumors.1 SGN-B7H4V is composed of a fully human IgG1 anti-B7-H4 monoclonal antibody (mAb) conjugated to the microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable peptide linker. SGN-B7H4V is designed to bind and internalize the immune checkpoint ligand B7-H4/ADC complex from the surface of malignant cells and release the cytotoxic payload MMAE. This ”vedotin” drug linker system has been clinically validated by multiple ADC programs, including brentuximab vedotin, enfortumab vedotin, and polatuzumab vedotin.2–4 Here, we characterize the target antigen B7-H4 and evaluate SGN-B7H4V activity in preclinical models.MethodsB7-H4 expression was characterized by RNA expression and immunohistochemistry across multiple solid tumor types. The ability of SGN-B7H4V to kill B7-H4-expressing tumor cells in vitro and in vivo in a variety of xenograft tumor models was also evaluated. Finally, the tolerability of SGN-B7H4V was assessed in rodent and non-human primate toxicology studies.ResultsImmunohistochemistry confirmed expression of B7-H4 across multiple solid tumor types, including ovarian and breast tumors. In vitro, upon binding to SGN-B7H4V, the immune checkpoint ligand B7-H4 was rapidly internalized and delivered the cytotoxic payload MMAE. Moreover, SGN-B7H4V killed B7-H4-expressing tumor cells in vitro by MMAE-mediated cytotoxicity, antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent cellular phagocytosis (ADCP). In vivo, SGN-B7H4V demonstrated strong anti-tumor activity in multiple xenograft models, including ovarian and breast cancer models. Activity was observed in models with both uniformly high and heterogeneous expression of B7-H4, consistent with robust bystander activity of vedotin ADCs. Finally, SGN-B7H4V was tolerated in both rat and non-human primate (NHP) toxicology studies at doses consistent with approved vedotin ADCs.ConclusionsB7-H4 is a promising ADC target expressed by several solid tumor types. SGN-B7H4V demonstrates robust anti-tumor activity in preclinical models through multiple potential mechanisms and is tolerated in rat and NHP toxicity studies. Altogether, these data support further evaluation of SGN-B7H4V in a planned, first-in-human phase 1 clinical study.AcknowledgementsWe would like to thank Kellie Spahr for conjugation support and Martha Anderson for in vivo biology support.ReferencesLeong SR, Liang WC, Wu Y, Crocker L, Cheng E, Sampath D, et al. An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer. Mol Pharm 2015;12(6):1717–29. Epub 2015/04/09. doi: 10.1021/mp5007745. PubMed PMID: 25853436.Rosenberg JE, O’Donnell PH, Balar AV, McGregor BA, Heath EI, Yu EY, et al. Pivotal trial of enfortumab vedotin in urothelial carcinoma after platinum and anti-programmed death 1/programmed death ligand 1 therapy. J Clin Oncol 2019;37(29):2592–600. Epub 2019/07/30. doi: 10.1200/JCO.19.01140. PubMed PMID: 31356140; PubMed Central PMCID: PMC.Senter PD, Sievers EL. The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Nat Biotechnol 2012;30(7):631–7. Epub 2012/07/12. doi: 10.1038/nbt.2289. PubMed PMID: 22781692.Tilly H, Morschhauser F, Bartlett NL, Mehta A, Salles G, Haioun C, et al. Polatuzumab vedotin in combination with immunochemotherapy in patients with previously untreated diffuse large B-cell lymphoma: an open-label, non-randomised, phase 1b-2 study. Lancet Oncol 2019;20(7):998–1010. Epub 2019/05/19. doi: 10.1016/S1470-2045(19)30091–9. PubMed PMID: 31101489.Ethics ApprovalAll animal studies were conducted in accordance with protocols reviewed and approved by the Institutional Animal Care and Use Committee at Seagen or the external testing facility that conducted the studies.

Abstract Background: The impact of financial toxicity (FT) on cancer patients is significant in terms of lost productivity and poor quality of life (QoL). Past studies have reported negative influence of high FT on patients actively undergoing treatment for breast cancer. However, existing data largely comes from quaternary referral centers, and the populations surveyed may not be generalizable in terms of income and insurance status across the United States. There is also limited understanding regarding the relationship between FT measured throughout the continuum of cancer care, demographics, disease factors, and QoL indicators in breast cancer survivors, particularly those from underserved communities. Methods: Breast cancer survivors who received treatment between 2015 and 2019 at Loma Linda University Cancer Center located in San Bernardino County, CA were invited to complete an anonymous online survey assessing demographics, disease history, FT, and QoL. A modified version of the Comprehensive Score for Financial Toxicity (COST) survey was used to assess FT at baseline and after treatment. The patient-reported outcomes measurement information system (PROMIS) survey was used to assess QoL. Demographic data were summarized using descriptive statistics. Associations between disease factors and FT measured at baseline and after treatment were analyzed using multivariable linear regression. Positive COST score coefficients indicate lower FT, while negative COST score coefficients indicate higher FT. Correlations between FT and QoL were evaluated using the Pearson correlation. Results: A total of 407 surveys were sent to breast cancer survivors who met study criteria, of whom 16% responded. Amongst 65 patients included in this analysis, the median age was 64 (IQR 56, 70), 68% were white (n = 44), 18% were unemployed, 13% had a high school or lower level of education, and 16% had an annual income &lt; $30,000. Mean COST score at baseline and after treatment were 21.6 ± 9.6 and 12.9 ± 7.8, respectively. During treatment, 21% of patients turned down or skipped treatment, 23% quit their job, and 15% reported family members quit their job. At baseline, lower FT was significantly associated with age &gt; 80 (6.2 95% CI: 4.1 to 8.3), presence of a college (4.5 95% CI: 1.4 to 10.4) or graduate degree (5.2 95% CI: 4.7 to 6.2), current employment (2.7 95% CI: 2.0 to 3.4), retiree status (6.7 95% CI: 0.4 to 13.0), and household income &gt; $30,000 (5.9 95% CI: 2.7 to 9.1) (p &lt; 0.05), while higher FT was significantly associated with Hispanic ethnicity (-4.1 95% CI: -6.7 to -1.5), Medicare (-1.6 95% CI: -5.2 to -2.0), and Medicaid insurance (-6.9 95% CI: -12.5 to -1.2) (p &lt; 0.05). After treatment, higher FT was significantly associated with receiving 3 or more combined modality treatments (-5.6 95% CI: -9.7 to -1.5) and having 5 or more treatment-related side effects (-6.0 95% CI: -10.4 to -1.6) (p &lt; 0.05). Finally, FT after treatment overall correlated positively with physical and mental health (Pearson coefficient 0.63 and 0.60 respectively, p &lt; 0.01). Conclusions: These findings suggest a significant association between FT, baseline demographics, treatment modalities, side effects, and quality of life in an underserved population of breast cancer survivors. In the future, FT should be assessed at baseline and throughout the continuum of breast cancer care to provide individualized assistance to patients facing financial strain, as it affects compliance to treatment which in turn can adversely affect cancer-related outcomes and QoL. Additional policies are needed to address the increasing cost of breast cancer care. Citation Format: Akhil Mehta, Jukes Namm, Ellen D'Errico, Eric Lau, Sharon Lum, Gayathri Nagaraj. Burden of financial toxicity in an underserved population of breast cancer survivors [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P4-11-25.

Abstract Background: Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults which is still incurable although novel drugs and new combination of chemotherapies are used . With the development of genetic and molecular biology technologies, more and more genes are found to be related to leukemogenesis and drug resistance of AML. TET2, a member of the ten-eleven-translocation gene family which can modify DNA by catalyzing the conversion of 5-mehtyl-cytosine to 5-hydroxymethyl-cytosine , is often inactivated through mutation or deletion in myeloid malignancies. Recent research reported that TET2 knock-down can promote proliferation of hematopoietic stem cells and leukemic cells. Also, several clinical studies showed that patients with TET2 mutation or low levels of TET2 expression have more aggressive disease courses than those with normal levels of TET2. However, the mechanism of the phenomenon is unknown. Our aim is to uncover how TET2 protein level is negatively correlated with AML cell proliferation and to provide a better view of target therapy in AML. Methods: We determined the expression levels of TET2 and other target genes in acute leukemia cell lines, bone marrow AML specimens, and peripheral blood mononuclear cells from healthy donors by qRT-PCR and Western blot. We also determined the mutation status of TET2 in AML cell lines. CCK8 and flow cytometry were used to determine cell proliferation, cell apoptosis, and cell cycle profile. Methylation-specific PCR were used to examine the methylation status in gene promoter regions. Also, we developed TET2 knock-down lentivirus to transfect AML cell lines to examine the effect of TET2 depletion. Last, RNA-seq was used to compare gene expression level changes between TET2 knock-down cell lines and the control cell lines. Results: AML cells from AML cell lines (KG-1,U937, Kasumi, HL-60, THP-1, and MV4-11) and AML patients' specimens expressed lower levels of TET2 than those of PBMC from the healthy donor (P<0.05). Among AML cell lines, U937 barely expressed TET2, while KG-1 expressed TET2 at a relatively higher level than those of other AML cell lines. We constructed a TET2 shRNA to transfect KG-1,THP-1,MV-4-11,Kasumi,and HL-60, and used qRT-PCR and western blot to verify the knock-down efficiency. CCK8 confirmed that knocking down TET2 could increase leukemia cell proliferation (P<0.05). Flow cytometry showed that cell cycle profile was altered in TET2 knock-down cells compared to the negative control cells. In order to identify target genes, we performed RNA-seq on wildtype and TET2 knockdown KG-1 cells and found that the expression of cell cycle related genes, DNA replication related genes, and some oncogenes were changed. We focused on Pim-1, an oncogene related to leukemogenesis, which was significantly up-regulated in the RNA-seq profile. Western blot and qPCR verified the RNA-seq results of Pim-1 expression in the transfected cells . Also, AML patients' bone marrow samples (n=35) were tested by qPCR and 28 of them were found to express low TET2 but high Pim-1 with the other 7 being opposite. For detailed exploration in expression regulation of Pim-1 via TET2, we screened genes affecting Pim-1 expression and found SHP-1, a tumor suppress gene which is often silenced by promoter methylation in AML. Western blot band of SHP-1 was attenuated in TET2 knockdown KG-1 cells. Moreover, methylation-specific PCR showed that after knocking down TET2 in KG-1 cell line, the promoter regions were methylated much more than the control cells. These results indicated that the function of TET2 in epigenetic modulation plays an important role in regulating Pim-1 expression. Finally, using flow cytometry and CCK8 we surprisingly found that knocking down TET2 expression could lead leukemic cells (KG-1, THP-1 and MV-4-11) more sensitive to Pim-1 inhibitor (SGI-1776 free base) and decitabine (a demethylation agent treating MDS and AML) (P<0.05). Conclusion: Our study showed that knocking down TET2 promoted leukemic cell proliferation. This phenomenon may correlate to Pim-1 up-regulation. Our clinical data also showed that the expression of TET2 and Pim-1 have an inverse relationship. The mechanism of TET2 regulating Pim-1 expression may be related to the epigenetic modulation function of TET2. Finally, we found TET2 downregulation could increase leukemia vulnerability to Pim-1 inhibitor and decitbine, and provide a novel view of target therapy in AML. Disclosures No relevant conflicts of interest to declare.

Abstract Relapsed or refractory (R/R) peripheral T-cell lymphoma (PTCL) is a family of aggressive lymphomas, with a median overall survival (OS) of less than 6 months. Current FDA approved therapies for R/R PTCL have modest overall response rates (ORR) of &lt; 30%. Duvelisib (DUV), a dual PI3K-δ,γ inhibitor, is FDA approved at 25 mg twice daily (BID) for the treatment of R/R chronic lymphocytic leukemia and R/R follicular lymphoma. On 10/3/2019, DUV received orphan designation for treatment of patients with R/R T-cell lymphomas. In the Phase 2, open-label, multi-center, parallel cohort PRIMO trial of DUV in R/R PTCL, the initial results of the dose-optimization phase (N=33) demonstrated a 54% ORR in the 75 mg BID (N=13) and 35% in the 25 mg BID (N=20) cohorts, respectively, by investigator assessment (INV). (NCT03372057; supported by Secura Bio). The expansion phase of PRIMO has a targeted enrollment of ~125 pts. Expansion phase eligibility criteria included histologically confirmed R/R PTCL after &gt;1 cycle of a prior standard regimen, a CD4 lymphocyte count of ≥ 50/mm 3 and required PJP prophylaxis. HSV/VZV prophylaxis was strongly recommended. Based on the dose optimization results, pts in the expansion phase receive DUV at 75 mg BID for 2 cycles to maximize rapid tumor control, followed by 25 mg BID to maintain long-term disease control and mitigate late toxicities, until progressive disease (PD) or unacceptable toxicity. The primary endpoint is ORR by IRC assessment, and secondary endpoints include ORR by INV assessment, duration of response (DOR), PFS, OS, disease control rate, and safety; all analyses consisted of pts that received at least 1 dose of DUV. This analysis is from an interim data cutoff as of May 21, 2021 that includes the first 6 months of data for the 78 patients included in the analysis. Pts had a median age of 66.5 years (range, 21-92 years) and a median of 3 prior lines of therapy (range, 1-7). The ORR by IRC assessment was 50% (39/78 patients) and the CR rate was 32.1% (25/78 patients), see Table 1. 14 patients (18%) remained on treatment; 37 pts discontinued due to PD (47.4%), 15 discontinued to due adverse events (19.2%) , 4 died (5.1%), and 1 each discontinued for secondary malignancy, lack of response, and withdrawal of consent. 5 patients (6.4%) discontinued therapy to undergo stem cell transplant, which suggests that DUV may be used as a bridge to transplant for appropriate patients. There were 3 deaths related or possibly related to duvelisib: pneumonitis, Epstein-Barr associated lymphoproliferative disorder, and sepsis. The most frequent &gt; Grade 3 adverse events seen were neutropenia (38.5%), ALT/AST increased (24.4%/ 21.8%), rash (7.7%), lymphocyte count decreased (7.7%), and sepsis (6.4%), see Table 2. ALT and/or AST elevations were the most common AEs leading to treatment discontinuations (N=12, 15.4%). The interim results of the first 78 patients in the PRIMO expansion phase show an ORR of 50% and a CR rate of 32%, which suggests this therapy is superior to currently available SOC therapeutic options. Duvelisib was well tolerated in this population and remained consistent with the known safety profile of DUV. These data, from a large diverse population of T cell lymphoma patients, build upon prior reports demonstrating DUV as an active oral treatment for pts with RR PTCL. Data from this interim analysis may be updated prior to the abstract presentation. Figure 1 Figure 1. Disclosures Brammer: Celgene: Research Funding; Kymera Therapeutics: Consultancy; Seattle Genetics: Speakers Bureau. Zinzani: BMS: Other: Advisory board, Speakers Bureau; ROCHE: Other, Speakers Bureau; SANDOZ: Other: Advisory board; ADC Therap.: Other; SERVIER: Other: Advisory board, Speakers Bureau; JANSSEN-CILAG: Other: Advisory board, Speakers Bureau; GILEAD: Other: Advisory board, Speakers Bureau; CELLTRION: Other: Advisory board, Speakers Bureau; EUSAPHARMA: Consultancy, Other, Speakers Bureau; TAKEDA: Other: Advisory board, Speakers Bureau; KYOWA KIRIN: Other, Speakers Bureau; NOVARTIS: Consultancy, Other, Speakers Bureau; TG Therapeutics: Other: Advisory board, Speakers Bureau; MSD: Consultancy, Other: Advisory board, Speakers Bureau; Incyte: Other, Speakers Bureau; Beigene: Other, Speakers Bureau; VERASTEM: Consultancy, Other: Advisory board, Speakers Bureau. Zain: Secura Bio, Ono , Legend, Kiyowa Kirin, Myeloid Therapeutics Verastem Daichi Sankyo: Consultancy; Secura Bio, DaichiSankyo, Abbvie: Research Funding; Kiyoaw Kirin, Secura Bio, Seattle Genetics: Honoraria. Casulo: BMS: Research Funding; Verastem: Research Funding; Genentech: Research Funding; Gilead: Research Funding. Jacobsen: Takeda: Consultancy; Syros: Consultancy; Janssen: Research Funding; Novartis: Research Funding; Pharmacyclics: Research Funding; Acerta: Research Funding. Gritti: Takeda: Consultancy; Roche: Consultancy; Kite Gilead: Consultancy; IQvia: Consultancy; Italfarmaco: Consultancy; Clinigen: Consultancy. Litwak: Secura Bio: Current Employment. Cohan: Secura Bio: Current Employment. Katz: Secura Bio: Current Employment. Mehta-Shah: C4 Therapeutics: Consultancy; Roche/Genentech: Research Funding; Kiowa Hakko Kirin: Consultancy; Karyopharm: Consultancy; Innate Pharmaceuticals: Research Funding; Celgene: Research Funding; Bristol Myers Squibb: Research Funding; AstraZeneca: Research Funding; Daiichi Sankyo: Consultancy, Research Funding; Secura Bio: Consultancy, Research Funding; Ono Pharmaceuticals: Consultancy; Corvus Pharmaceuticals: Research Funding; Verastem: Research Funding. Horwitz: ADC Therapeutics, Affimed, Aileron, Celgene, Daiichi Sankyo, Forty Seven, Inc., Kyowa Hakko Kirin, Millennium /Takeda, Seattle Genetics, Trillium Therapeutics, and Verastem/SecuraBio.: Consultancy, Research Funding; Affimed: Research Funding; Aileron: Research Funding; Acrotech Biopharma, Affimed, ADC Therapeutics, Astex, Merck, Portola Pharma, C4 Therapeutics, Celgene, Janssen, Kura Oncology, Kyowa Hakko Kirin, Myeloid Therapeutics, ONO Pharmaceuticals, Seattle Genetics, Shoreline Biosciences, Inc, Takeda, Trillium Th: Consultancy; Celgene: Research Funding; C4 Therapeutics: Consultancy; Crispr Therapeutics: Research Funding; Daiichi Sankyo: Research Funding; Forty Seven, Inc.: Research Funding; Kura Oncology: Consultancy; Kyowa Hakko Kirin: Consultancy, Research Funding; Millennium/Takeda: Research Funding; Myeloid Therapeutics: Consultancy; ONO Pharmaceuticals: Consultancy; Seattle Genetics: Consultancy, Research Funding; Secura Bio: Consultancy; Shoreline Biosciences, Inc.: Consultancy; Takeda: Consultancy; Trillium Therapeutics: Consultancy, Research Funding; Tubulis: Consultancy; Verastem/Securabio: Research Funding. OffLabel Disclosure: Duvelisib is approved in relapsed/refraction CLL/SLL and FL. This study evaluates duvelisib in PTCL

Empirical studies proved that good corporate governance had a positive link to the success of an organization. Good in directing and managing organizational processes, structures, and information mean satisfaction guaranteed was given to all stakeholders. Essential factor like working atmosphere may be considered when looking into corporate governance as well as organizational success. However, limited literature focused on the importance of communication climate and its connection to corporate governance and organizational success. Hence, this study looked into the predicting effect of communication climate to perceived corporate governance and organizational success. A total of ninety-eight rank and file employees voluntarily participated in accomplishing three questionnaires such as the Communication Climate Inventory by Costigen & Schiedler; Corporate Governance Survey adapted from Wickramanayake’s Seven Characteristics of Corporate Governance; and Organizational Success Survey adapted from Ilyas & Rafig used to measure communication climate, corporate governance, and organizational success respectively. Results revealed that communication climate was a predictor of perceived corporate governance and organizational success. This implied that the role of supervisors in setting work conditions was essential on how rank and file employees perceived corporate governance and organizational success.ReferencesAbdu Rashid, M., Azman bin Othman, M., Zainudin bin Othman, M., Ain bt Arshad, F. (2015). The influence of work environment on employees job performance: a case study of Administrative staff in a manufacturing industry. 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Background: Interleukin-2-Inducible T-Cell Kinase (ITK) is a Tec-family, non-receptor tyrosine kinase expressed in T-cells that plays a key role in T-cell receptor (TCR) signaling, which is required for development and differentiation of T-cells. In T-cell lymphoproliferative disorders, expression of the TCR and its downstream signaling components, including ITK, are maintained which suggests malignant T cells exploit this growth and survival pathway to their advantage. Antigen-presenting cells, abundant in the lymphoma microenvironment, also may provide antigen to drive TCR signaling through ITK. CPI-818 is a first-in-class, irreversible ITK inhibitor with selectivity for ITK. In preclinical studies, CPI-818 blocks TCR signaling in vitro and is efficacious in murine models and canines with T-cell lymphomas. We report results from the dose escalation portion of an ongoing phase 1/1b trial of CPI-818 in patients with relapsed/refractory T-cell lymphoma (CPI-818-001 study, NCT03952078). The trial is being conducted at sites in the United States, Australia, and South Korea. Methods: In dose-escalation, cohorts (3+3 design) enrolled patients with cutaneous and peripheral T-cell lymphoma who have progressed on, refractory to, relapsed, or intolerant to at least 2 standard therapies; age ≥ 18 years; ECOG status 0-1; and adequate organ function. CPI-818 was administered in ascending dose levels (100, 200, 400, 600mg BID) continuously for up to sixteen 21-day cycles, until progression or unacceptable toxicity. In dose expansion, PTCL-NOS and CTCL patients are receiving CPI-818 at a dose of 600 mg BID. The primary objectives of the study are to evaluate the safety and to establish the maximum tolerated dose (MTD) or the maximum administered dose of CPI-818. Safety events will be assessed according to the NCI-CTCAEv5. Secondary objectives include evaluating pharmacokinetics and efficacy as assessed by the investigator using standard response criteria at the end of every 3 cycles. ITK occupancy in peripheral blood T cells and tumor tissue as well as biomarkers associated with anti-tumor activity in tumor and blood samples are being evaluated. Results: In dose-escalation, sixteen patients were enrolled in four cohorts: 100 mg BID (n=4), 200 mg BID (n=3), 400 mg BID (n=5), and 600 mg BID (n=4). No dose-limiting toxicities were observed in any of these cohorts and the MTD was not reached. Treatment related adverse events (TRAEs) were reported in 9 (47.4%) patients and were all Grade 1-2 in severity. The most common (&gt;1 patient) were fatigue (15.8%), nausea (10.5%), and rash (10.5%) and no infections were reported. By flow cytometry, no consistent changes in circulating non-malignant or total T cell number or phenotype were observed. Pharmacodynamic analysis revealed ITK engagement by CPI-818 in all cohorts when CPI-818 is dosed BID. With increasing dose, the trough ITK occupancy in both blood and tissue increased. At doses of 200 mg and greater, trough occupancies were &gt;75%. Near complete ITK inhibition (98%) was achieved at 600 mg BID and therefore, this dose was selected as the expansion cohort dose and higher doses were not explored. Reduction in serum cytokines including IL2 (six of eight patients), IFNg (eight of eight patients), and TNFa (eight of eight patients) was observed 24hr post-dose in patients treated with doses of 400 and 600mg, but not at lower doses. In dose escalation, a total of four PTCL patients were enrolled at doses of 200 mg BID or greater. A confirmed complete response was achieved in one PTCL-NOS patient in the 200mg BID cohort. Among 7 CTCL patients enrolled, a Nodal CR, improved mSWAT and slowing of Sézary cell expansion were seen (Figure 1). Given the safety profile, the PK/PD findings, and the early signs of efficacy, PTCL-NOS and CTCL cohorts were expanded at 600mg BID. To date, two patients with PTCL-NOS and one patient with CTCL have been recently enrolled in expansion cohorts. Conclusion: The dose-escalation part of the CPI-818-001 trial demonstrated that the 100, 200, 400 and 600 mg BID doses are well tolerated. Clinical activity was observed in both PTCL-NOS and CTCL. Reduction of serum levels of canonical T cell cytokines is consistent with on-mechanism drug inhibition of inflammatory T cell pathways. Disease specific expansion cohorts for PTCL-NOS and CTCL are enrolling patients at a dose of 600 mg BID. Disclosures Khodadoust: Seattle Genetics: Consultancy; Kyowa Kirin: Consultancy. Feldman:Abbvie: Honoraria; Pharmacyclics: Honoraria, Other, Speakers Bureau; Amgen: Research Funding; Cell Medica: Research Funding; Eisai: Research Funding; Kyowa Kirin: Consultancy, Research Funding; Pfizer: Research Funding; Portola: Research Funding; Janssen: Speakers Bureau; AstraZeneca: Consultancy; Seattle Genetics, Inc.: Consultancy, Honoraria, Other: Travel expenses, Research Funding, Speakers Bureau; Takeda: Honoraria, Other: Travel expenses; Celgene: Honoraria, Research Funding; Kite: Honoraria, Other: Travel expenses, Speakers Bureau; BMS: Consultancy, Honoraria, Research Funding; Corvus: Research Funding; Rhizen: Research Funding; Viracta: Research Funding; Trillium: Research Funding; Bayer: Consultancy, Honoraria. Yoon:Celltrion: Honoraria; Samyang: Research Funding; Amgen, Chongkundang, Celgene, Astrazeneca: Consultancy. Kim:miRagen: Research Funding; Elorac: Research Funding; Neumedicine: Consultancy, Research Funding; Horizon Pharma: Consultancy, Research Funding; Innate Pharma: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Kyowa-Kirin Pharma: Research Funding; Medivir: Membership on an entity's Board of Directors or advisory committees; Forty Seven Inc: Research Funding; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding; Trillium: Research Funding; Eisai: Membership on an entity's Board of Directors or advisory committees, Research Funding; Corvus: Research Funding; Merck: Research Funding; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees; Portola: Research Funding; Solingenix: Research Funding; Galderma: Membership on an entity's Board of Directors or advisory committees, Research Funding. Mehta-Shah:Karyopharm Therapeutics: Consultancy; Verastem: Research Funding; Innate Pharmaceuticals: Research Funding; Celgene: Research Funding; Kyowa Hakko Kirin: Consultancy; Corvus: Research Funding; Bristol Myers-Squibb: Research Funding; C4 Therapeutics: Consultancy; Genetech/Roche: Research Funding. Kim:Mundipharma: Research Funding; Donga: Research Funding; Kyowa Kirn: Research Funding; Celltrion: Research Funding; JJ: Research Funding; Pfizer: Research Funding; F. Hoffmann-La Roche: Research Funding. Horwitz:ASTEX: Consultancy; Janssen: Consultancy; Kura Oncology: Consultancy; Miragen: Consultancy; Myeloid Therapeutics: Consultancy; Verastem: Consultancy, Research Funding; Vividion Therapeutics: Consultancy; Affirmed: Consultancy; C4 Therapeutics: Consultancy; Daiichi Sankyo: Research Funding; Celgene: Consultancy, Research Funding; Forty Seven: Consultancy, Research Funding; Infinity/Verastem: Research Funding; Kyowa Hakka Kirin: Consultancy, Research Funding; Millenium/Takeda: Consultancy, Research Funding; Seattle Genetics: Consultancy, Research Funding; Trillium: Consultancy, Research Funding; Corvus: Consultancy; Innate Pharma: Consultancy; Mundipharma: Consultancy; Portola: Consultancy, Research Funding; Beigene: Consultancy; Aileron: Consultancy, Research Funding; ADCT Therapeutics: Consultancy, Research Funding; GlaxoSmithKline: Consultancy. Buggy:Corvus Pharmaceuticals: Consultancy, Current Employment, Current equity holder in publicly-traded company. Hotson:Corvus Pharmaceuticals: Current Employment. Hill:Corvus Pharmaceuticals: Current Employment, Current equity holder in publicly-traded company. Munneke:Corvus Pharmaceuticals: Current Employment. Mahabhashyam:Corvus Pharmaceuticals: Current Employment. Miller:Corvus Pharmaceuticals: Current Employment, Current equity holder in publicly-traded company. Janc:Corvus Pharmaceuticals: Current Employment, Current equity holder in publicly-traded company. Mobasher:Corvus Pharmaceuticals: Current Employment, Current equity holder in publicly-traded company.

Bir yerin aile yapısını anlamak sosyal ve ekonomik yapısını anlamak kadar önemlidir. Bu çalışmada 1760-1766 yılları arasında Antakya Kazası’nda ailenin yapısını araştırmak hedeflenmiştir. Osmanlı Devleti’nde hukuki işlemlerin kaydedildiği kadı sicilleri aile yapısı hakkında da hayli bilgi vermektedir. Bu sebeple araştırma için belirtilen tarihler arasındaki şeriyye sicillerinden faydalanılmıştır. Çalışmanın amacı 1760-1766 yılları arasında Antakya Kazası kadı sicillerindeki belgelerde ailenin oluşumu ve dağılımının yanı sıra ailenin sosyal ve ekonomik yapısı hakkında bilgileri de tespit etmektir. Ailenin yapısını iyi anlamak için nişan, evlenme, mehir, boşanma, eş ve çocuk sayılarıyla ilgili bilgiler ele alınmıştır. Ayrıca ailenin yaşam alanı ve kullanılan eşyalar tespit edilmeye çalışılmıştır. Aile oluşumunda tarafların anlaşarak nişanlanması ve bu nişanın bozulmasıyla çıkan anlaşmazlıkların mahkemeye yansıdığı, aynı zamanda boşanma için de mahkemeye başvurulduğu görülmektedir. Evlenme sırasında veya evlilik sonrasında erkeğin kadına vermesi gereken mehir miktarı ile ailenin yaşadığı mahalle, ev tipleri ve kullanılan eşyalarla ilgili bilgiler verilmiştir. Bu bilgiler Antakya Kazası’nda aile yapısı, toplumun sosyal, ekonomik ve kültürel yaşayışını belirli ölçüde de olsa ortaya koymaktadır.

AbstractFollowing E. Wigner’s original vision, we prove that sampling the eigenvalue gaps within the bulk spectrum of a fixed (deformed) Wigner matrix H yields the celebrated Wigner-Dyson-Mehta universal statistics with high probability. Similarly, we prove universality for a monoparametric family of deformed Wigner matrices $$H+xA$$ H + x A with a deterministic Hermitian matrix A and a fixed Wigner matrix H, just using the randomness of a single scalar real random variable x. Both results constitute quenched versions of bulk universality that has so far only been proven in annealed sense with respect to the probability space of the matrix ensemble.

Ultrastructural features of the nematode Trichostrongylus tenuis were studied. Helminthological studies were carried out in the Nakhchivan Autonomous Republic in 2015–2018. The material from domestic waterfowl was collected by the method of complete parasitological dissection. Along with the fact that this helminth is a specific parasite of domestic waterfowl, it dominates among all the types of helminths noted by us and is the cause of serious changes in the host organism. The study of the ultrastructure of the nematode T. tenuis is important for identifying parasitic-host relationships, clarifying the systematic position of parasites and in preparing measures to combat these parasites. In addition, a wide variety of morphological features of the lateral alae, allows them to be used as one of the main features for identifying helminth species. The article first presents data on the ultrastructural features of the lateral alae of the nematode T. tenuis. As a result of the studies, it was found that, despite the fact that in some parasitic nematodes of the Trichostrongylidae family the morphological structure of the lateral alae of the cuticle is identical over the entire surface of the body, in the nematode T. tenuis belonging to the same family, four forms were revealed during ultrastructural studies, which were represented using diagrams and electron diffraction patterns. Lateral alae consist of cortical, homogeneous, and fibrillary layers differing in size, thickness, and other features. From the front (oral) part of body of the nematode T. tenuis to the beginning of the intestine, the cuticle is smooth; on the body part from the small intestine and behind it, lateral alae begin to be observed, which resemble a “ridge” in shape. When approaching the posterior end of the body, the lateral alae take the form of “hooks”. On the caudal region, the lateral alae become even more complicated and get the form of “spikes”, and relatively small outgrowths are additionally observed on these lateral wings. These signs can be used to clarify the taxonomic position of helminth species.

This paper discusses Deepa Mehta’s lighthearted romantic comedy Bollywood/Hollywood as a representation of the Indian diasporic community settled in Canada. What makes this film especially interesting is that it focuses on how, for overseas Indians, Bollywood offers the possibility of accessing the home culture in a globalised world. Bollywood as an industry is synonymous with the genre of family melodrama, and when Mehta uses this term it represents, not just the Bombay Film Industry, but also the cultural iconicity of the genre, which in turn represents the film sensibility of the entire ‘mass’ of Indians located within the country and in the diaspora. At one level, the film is a lighthearted comic portrayal of the Indo-Canadian community in Toronto and its strong connection with “our magnificent Indian culture” (B/H) through the Hindi movies churned out by Bollywood. At a closer look at a number of scenes, light is cast on the way Deepa Mehta emphasizes the cultural divides through interesting narrative and visual constructions. The actual argument of the film emerges in a dialectical reading and recognition of the oppositional forces operating within and without the narrative world. What is particularly striking about this film is its self-reflexivity. It announces itself as a Bollywood melodrama and celebrates this identity. Bollywood is thus positioned as both a subject and an object of contemplation—a world of Cinema that is a part of our memory and a vehicle of history. The critique of the formula also comes from within the formulaic narrative itself. Deepa Mehta constantly uses the genre and also plays around with it in interesting ways

Mostly the people of the villages in Mehsi block of East Champaran are engaged in farming and animal husbandry and farm labour. The farmers of this village are also engaged in growing vegetables and spice crops for sale in the nearest markets. Mr Vijay Kumar was not able to maintain his family with farming occupation alone earlier. He earned 2-3 lakhs rupees annually by selling honey and bee colonies in nearby markets and at district level market. He set good example for enabling extra income along with agriculture. He established bee keeping unit in his farm along with agricultural crops. After establishing his venture, he is able to meet the local demand by providing good quality of honey and bee colonies to villagers. Despite earlier challenges like lack of market for his honey and difficulty in managing his colonies during the summer, Mr. Kumar has dramatically changed his life and that of his family through the sale of honey and honeybee colonies

As writing itself has been an indispensable part of the diasporic expression, what remains integral is its history encrypted in every experience. With time and over generations, diaspora writing has witnessed a tremendous diversity of experience and their consequent expression. For instance, the long history of Sikh immigration to Canada doesn’t obfuscate substantial moments of identity negotiation, group solidarity, co-creation, and cooperation along with the invented mechanisms of social hierarchies and differences which exhibit the least discontinuity in the diaspora. The case for the present study is the story of a Punjabi Sikh Dalit family of Mahia Ram Mehmi, in Canada since 1906 sourced from South Asian American Digital Archive (SAADA) penned by Riya Lalitha. This paper comprehends the Sikh diaspora society in Canada keeping sight of the following objectives: (i) How religious practice is intertwined with the social system? (ii) How community advocacy may realize the tangible goal of prejudice (for example, caste) liberation in society? Explorations into this story will unfold the deep abyss of social hierarchy dividing the diaspora and the entire institutional mechanism growing out of such geopolitical circumstances such as Apna Gurudwara, Chetna Foundation, International Dalit Conference (IDC), etc.

Papers N Parcels (hereafter PnP) is an end-to-end logistics business organization founded in 2018 by Tilak Mehta, who was a teenager at the time. The capital that supported the initial activity of the company was derived from family investments. The company has an efficient business model and gains a competitive advantage by setting up its primary objectives and strategies, which position it for success. PnP aims to deliver its products within 4–8 h of an order, which is the fastest rate among existing delivery companies. The parcels are picked up from the end customers and delivered to the recipient company’s main hub. From there, the parcel is sent to the final recipient with the help of the PnP app. This approach streamlines the process, and the time involved is very minimal. The business model of this fast-moving company was new and unique. The case study highlights how effectively PnP capitalizes on the vast network of dabbawalas (lunchbox deliverymen) in Mumbai who use the PnP app.

Introduction: Sexual health is an important aspect of public health, especially in women. Healthy and satisfying sexual intercourse is an important factor in maintaining family health and preventing sexual disorders. In Iran, the prevalence of women sexual disorders was reported 31-72% in different age groups. The purpose of this study was to investigate the effect of a post marriage marital skills educational program on sexual function of women referring to the marriage counseling center of Mehriz City in 2020. Methods: This quasi-experimental study was conducted on 72 women who had been married for 6 months to one year. The participants were divided into the control (n = 36) and intervention (n = 36) groups. The data were collected using female sexual function index (FSTI) questionnaire. The intervention group was educated in 4 sessions of 120 minutes. Data analysis was performed by SPSS version 22 using descriptive and analytical statistics. Results: The mean age of the subjects in the intervention group was 22.58±4.83 and in the control group was 21.83±4.01years. The results showed that after the educational intervention, the mean score of sexual function increased significantly from 22.9 to 27 in the intervention group (p <0.05). There was also a significant increase in sexual desire, psychological stimulation, vaginal moisture, orgasm, satisfaction and a decrease in sexual pain (p <0.05). In the control group, the mean score of sexual function did not change significantly. Conclusion: It seems that the designed intervention of marital skills education on women's sexual function had a significant effect on all dimensions of sexual function. It is recommended that educational-counseling interventions be performed after marriage in health centers.

Background: One of the factors influencing the level of general health and quality of life of individuals, is the level of social support that people enjoy. Given the importance of general health, quality of life and the amount of social support and their relationship with the level of physical activity in young people in Yazd province counties were studied. Methods: The study population of this descriptive, cross-sectional study consisted of 15- to 29-year-old people. Given the study population, sample size was calculated for the counties Yazd, Mehriz, Ardakan and Meybod separately. Methods: A total of 1533 people were selected by cluster sampling, and a person aged 15-29 years from each family completed the questionnaire. The questionnaire used, in addition to demographic questions, included three sections general health questionnaire (GHQ-28), Multidimensional Scale of Perceived Social Support, and World Health Organization Quality Of Life Brief (WHOQOL-BREF). The data were analyzed by SPSS18, nonparametric statistical tests and Pearson's correlation. Results: The mean general health score of youth was 30.82 (9.56) and the mean scores of their quality of life and social support were 38.32 (8.67) and 42.64 (7.73), respectively. Mental health, quality of life and social support were significantly associated with education level (P-value ≤ 0.001). The quality of life of young athletes was higher than that of young non-athletes (P-value ≤ 0.001). General health and social support were higher in women than in men (P-value ≤ 0.001). Conclusion: The general health level of Yazd youth is higher than the cut-off point and not optimal, but based on social and cultural conditions in this province, the levels of social support and quality of life were found to be satisfactory. Planning to increase the level of vitality and exercise in different fields can be an opportunity to improve the general health of young people.

This paper discusses the presentation of fame that can be identified through popular search terms. These terms reveal how the rapidly shifting interest in individual identities of ‘fame’ are cast against a continuous sequence of expected and unexpected events including movie releases, annual holidays, murders and terrorist attacks. The central claim of this paper is that fame is continuously reconstituted across a wide spectrum of cultural experiences and actions. Fame is attached to individuals as a personification of mainstream cultural fascination with specific events – whether manufactured or unexpected – and artefacts. This paper takes up the argument of Tyler (204) and Tomas (31) that promotes the potential of the Internet, and particularly the Web, as a ‘social laboratory’ that offers the means to rapidly and continuously identify the activities and interest of contemporary ‘everyday life’. This contrasts with positions that argue for the significance of the Internet in distinction and as a distinct space (Stone; Stallabrass; cf. Liff, Steward & Watts 97). However, this paper is not ‘another’ paper about the Internet or the Web. The data used in its discussion is admittedly gathered from this realm but is used as evidence into a wider framework of contemporary culture(s) that is media obsessed. This obsession both shapes and draws upon the transitory fame of individuals to frame and structure a form (or an illusion) of cultural continuity through a continuous presentation of events relating to ‘their’ fame. Fame is culturally achieved (Rojek 18) (manufactured) at various historical intersections of events and artefacts with their expression as a search term being just one indicator. Fame is not something that can be individually self-assumed as the (desperate) efforts in the UK of glamour model Jodie Marsh (Befuddle) (and others) often prove. Considered individually, the realisation of one’s fame can be seen as providence and the identification of ‘luck’ is an often cited basis for the possession of fame (Rojek 37). This is certainly a common explanation given by ‘famous people’ in ‘candid’ interviews. However, clear parallels can be seen in the analysis of invention (Boorstin 11). Inventions do not appear unexpectedly or in the absence of a need, they are a cultural response that occurs irrespective of the individual ‘genius’ of an inventor. The achievement of fame fulfills a similar cultural need at a particular historical moment. If Pamela Anderson had not achieved fame then – inevitably – another woman who could offer the contemporary idealised artefact of the female body would be available to be heavily represented through popular Web searches. The lists of search terms were gathered from wordtracker’s “Top 500 Search Terms” newsletter and represent the most popular search terms from September 2001 to February 2003. The terms that are found consistently at the top of the lists tend to be generic, for example ‘sex’, ‘autos’, ‘free music’ and ‘films’. Another predominant set of terms that repeatedly appear are the partial or full address of the most popular Web sites such as hotmail.com, yahoo.com and ebay.com. The lists of search terms also reveals the continuous importance of file sharing technologies, the commodification of women’s bodies through pornographic Web sites (MacKinnon in Mehta & Plaza 55) and the use of the Internet to gather copyrighted or even illicit goods for free such as music, software, warez and serialz. Fame – in the form that it can be identified through popular Web search terms – is heavily represented by individual media figures of either television or film. However, these people are not exclusively ‘mainstream’ actors. This is revealed through the public expression of ‘private’ cultural knowledges of ‘adult’ actors such as Tawny Kitaen or Tera Patrick. For the majority of these individuals who can be identified through popular search terms few receive a sustained level of interest beyond a few weeks blurring the observation of fleeting fame with that of momentary popularity. These brief expressions of interest are mechanical and even predictable forms of fame. Tera Patrick’s single appearance as a popular search terms occurred the day after she re-signed to host a Playboy Television program, “Nightcalls 411”. The surge of interest in Tawny Kitaen paralleled her arrest for spousal abuse and battery on her professional baseball playing husband. Interest in Natalie Portman and Orlando Bloom, two of the most popular ‘conventional’ actors observed in the lists of popular search terms (with Bloom as one of the few men regularly included in the lists) is more mundanely linked with the release of the films in which they appear. Outside of these specific events interest in these ‘younger’ actors does not rise to a significant level that is sufficient to appear within the lists of popular search terms. It is Pamela Anderson, however, who solely achieves sustained long-term individual search engine popularity. Anderson’s life (rather than her career) provides a continuous stream of moments and events that sustain attention in her as a popular search term. In November 2001, Anderson had a miscarriage and received a surge of interest as a search term; in March 2002 she announced that she had contracted Hepatitis C after sharing a tattoo needle with her former husband this was followed by a surge of interest as a search term. One month later she announced her engagement to Kid Rock which provoked another spike of interest. By June 2002 Anderson’s V.I.P. television series had been dropped by her network while she simultaneously announced involvement with a animation project called Stripperella, a combination that again peaked interest in her as a search term. Fame, in this context of celebrity and drawing upon these examples, can be seen as being as much related to negative moments in these individual’s lives as it is to success in their chosen field. This suggests that one parameter of search engine interest in fame revolves around revelations of the ‘normality’ of individuals such as Anderson. Bloom and Portman, in contrast, do not attract this attention possibly through their lack of ‘history’ but more plausibly by their adherence to the script of events manufactured ‘for them’ regarding their careers rather than ‘by them’ and about their ‘real’ lives. Baudrillard (41) observed that “in earlier time an event was something that happened – now it is something that is designed to happen. It occurs, therefore as a virtual artefact, as a reflection of pre-existing media-defined forms.” This observation is a harbinger to bin Laden’s spectacular manipulation of western mainstream media by bringing an apparently spontaneous event to the public gaze. The terms gathered from the Web search engine offer an alternative parameter for fame – achieved through the spectacle of unexpected public events. Most prominently is the identity (and misspellings) of Osama bin Laden however others also obtain fame through equally unexpected events (unexpected at least for those who experience it and for the mainstream media who act as an accomplice). Unexpected events, and arguably infamy or notoriety (Rojek 12), do not, however, necessarily ensure any greater persistence of fame. Osama bin Laden, perhaps the exception, as a consequence of his general identification as the architect of the 11 September 2001 bombings, is evident in popular search terms for a period of months after the attacks. This fame is evident in a different form to that of television, film or musically oriented fame. Osama bin Laden became an instant and dominating search term immediately after the September 11 terrorist attacks. After this, interest in this event, and arguably bin Laden’s individual fame, gradually dropped away over a number of weeks until disappearing completely – echoing what Rojek observes as the inevitable evanescence of fame The notoriety of bin Laden was eventually subsumed and extinguished by mainstream US politics which encouraged a shift towards its own hegemonic agendas including – most notably – the political regime of Iraq. Other unexpected forms of fame are also related to specific moments of conflict, tension or aggression. Daniel Pearl, the US journalist, experienced a brief posthumous form of fame in May 2002 when he was beheaded in Afghanistan after being accused of spying. However, it was not the execution or the death of Pearl that primarily contributed to this sudden and unexpected interest. More significantly – for a Web enabled culture – was the relatively ready availability online of a video recording of the beheading. The motivation for the video being placed online, despite being formally banned by the US government, was a political action that defended the American belief in the right to freedom of speech. However, popular interest in this video is arguably more closely related to the perverse and voyeuristic cultural traits of contemporary mainstream culture (that is proved so regularly through many of the most popular search terms). The discovery of Chandra Levy’s body in a Washington D.C. park in May 2002 also offered brief posthumous fame. However, the interest in ‘Klingle Mansion’ – one of the last things Levy searched for on the Web before she disappeared 13 months earlier – suggests a perverse interest in the details of the murder, its peculiarities and Levy’s relationship to a Democrat senator rather than an expression of sympathy or grief for the murdered woman or her family. DeBord (thesis 60) claims that “media stars are spectacular representations of living human beings, distilling the essence of the spectacle’s banality into images of possible roles. Stardom is a diversification in the semblance of life.” In many respects identifying the difference between unexpected, ‘lived’ or manufactured fame offers little for extending the critical understanding of fame itself. Regular and unexpected events are not the sole determinant of fame, however, the close association between ‘being’ a popular search term and moments in one’s life suggests that this articulation of fame is closely driven by an ever-changing pastiche of personal, local and global events. Increasingly, these events are articulated through popular search terms revealing the role of the Web as a guide to broader mainstream cultural attitudes. “Our” interest with fame is a product of contemporary event-driven culture in all its variations. “Our” construction of fame is also produced by this same culture. The popular identification of individual fame shifts to meet prevailing cultural “needs”. These needs are expressed as, among other things, tabloid articles, ‘candid’ television interviews and Web search terms. References Baudrillard, J. The Transparency of Evil. Trans. J. Benedict. London: Verso, 1993. Befuddle. “Jodie Marsh Drunk Collection.” http://www.befuddle.co.uk/celebs/celebs_jodie_marsh.html>. Boorstin, D. Hidden History: Exploring Our Secret Past. New York: Vintage, 1989. DeBord, G. Society of the Spectacle. Trans. D.Nicholson-Smith. New York: Zone Books, 1994. Liff, S, F. Steward and P. Watts. “From the Social to the Virtual … and Back Again.” Virtual Society? Get Real! Ed. S Woolgar. Oxford: Oxford University Press, 2002. McLaren, C. “Celebs, Freaks, Media Lit: Interview with Joshua Gamson.” Stay Free! 15 (1998). http://www.stayfreemagazine.org/archives/15/josh.html>. Mehta, M., and D. Plaza. “A Content Analysis of Pornographic Images on the Internet.” The Information Society 13.2 (1997): 153-61. Rojek, C. Celebrity. London: Reaktion Books, 2001. Stallabrass, J. “Empowering Technology: The Exploration of Cyberspace.” New Left Review 211 (1995): 3-32. Stone, A. “Will the Real Body Please Stand Up: Boundary Stories about Virtual Cultures.” Cyberspace: First Steps. Ed. M. Benedikt. Cambridge, MA: MIT Press, 1991. Tomas, D. “Old Ritual for New Spaces.” Cyberspace: First Steps. Ed. M. Benedikt. Cambridge, MA: MIT Press, 1991. Tyler, T. “Is the Internet Changing Social Life? It Seems the More Things Change, the More They Stay the Same.” Journal of Social Issues 58.1 (2002): 195-205. Citation reference for this article MLA Style Fletcher, Gordon. "An Index of Fame?: Critical Identifications of Fame in the 'Social Laboratory'." M/C Journal 7.5 (2004). echo date('d M. Y'); ?> <http://journal.media-culture.org.au/0411/06-fletcher.php>. APA Style Fletcher, G. (Nov. 2004) "An Index of Fame?: Critical Identifications of Fame in the 'Social Laboratory'," M/C Journal, 7(5). Retrieved echo date('d M. Y'); ?> from <http://journal.media-culture.org.au/0411/06-fletcher.php>.

An Ethical Approval Statement or Statement of Informed Consent should have been included for the articles listed below. Their corresponding statements are presented following the article information: Kolge NE, Patni VJ, Potnis S. Semi-permanent Substitution of Maxillary Anterior Teeth: TADs Supported Approach. Journal of Indian Orthodontic Society. 2019;53(2):148-150. doi:10.1177/0301574219841176 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Doshi UH. Precise Placement of Fixed Retainers Using Mini Molds. Journal of Indian Orthodontic Society. 2019;53(3):206-207. doi:10.1177/0301574219851625 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Mohan S, Reddy CM, Jain S. A Simple Spring Mechanics for Molar Intrusion. Journal of Indian Orthodontic Society. 2019;53(3):208-210. doi:10.1177/0301574219853078 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Ahluwalia R, Srivastava S, Garg H. A Simple Technique for Retrieval of Fractured Mini-implant. Journal of Indian Orthodontic Society. 2019;53(3):211-212. doi:10.1177/0301574219853723 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Bhupali NR, Verma RK, Verma S, Singh SP. Welded Archwire Hooks. Journal of Indian Orthodontic Society. 2019;53(3):213-214. doi:10.1177/0301574219861203 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Ratre R, Jain S, Chourse S. Guide Hook to Prevent Trauma to Soft Tissues by Retraction Element Used with TAD. Journal of Indian Orthodontic Society. 2019;53(3):215-216. doi:10.1177/0301574219861206 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Ambekar VR, Mathur AK, Thushar BK. Keychain Attachment. Journal of Indian Orthodontic Society. 2019;53(4):287-288. doi:10.1177/0301574219865365 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Dhar S. Camouflage of Skeletal Class III Malocclusion in an Adult Male Using Miniscrew Anchorage From the External Oblique Ridge in Conjunction With Face Mask Wear. Journal of Indian Orthodontic Society. 2019;53(4):289-294. doi:10.1177/0301574219865358 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Nayak A. Indian board of Orthodontics Case Report: Orthodontic Management of a Palatally Impacted Maxillary Canine. Journal of Indian Orthodontic Society. 2019;53(4):295-305. doi:10.1177/0301574219884495 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Johnson MP, Leone JM. Case Report: Correction of Class II Div 2 Malocclusion With Maxillary Arch Extraction and Lower IPR. Journal of Family Issues. 2020;54(1):322-349. doi:10.1177/0192513X04270345 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Singh GP, Nehra K, Mitra R, Nakra O, Singla A. Orthosurgical Management of Class III Malocclusion Emphasizing the Pivotal Role of CBCT. Journal of Indian Orthodontic Society. 2020;54(1):69-76. doi:10.1177/0301574219888056 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Chitra P. A New Approach to Prevent Crown Loosening and Caries in the AdvanSync2 Class II Corrector. Journal of Indian Orthodontic Society. 2020;54(1):77-79. doi:10.1177/0301574219886706 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Takane V, Nagaraj K, Keshan D, Keluskar K. A Unique Treatment Approach for Orthodontic Correction of a Unilateral Maxillary Canine-Lateral Incisor Transposition with Contralateral Impacted Maxillary Second Premolar. Journal of Indian Orthodontic Society. 2020;54(2):142-146. doi:10.1177/0301574219889140 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. George AM, Vakil KK, Govindaraj A, Kumar MV, Gautam R, Nene S. Formulating a New Orthodontic Index: An Indian Board of Orthodontics Initiative. Journal of Indian Orthodontic Society. 2020;54(2):147-149. doi:10.1177/0301574220919216 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Verma S. Case Report: Orthosurgical Management of Skeletal Class III Malocclusion. Journal of Indian Orthodontic Society. 2020;54(2):150-156. doi:10.1177/0301574220919219 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Gupta K, Khare R, Agrawal N, Chaukse A, Gupta NN. Retainer Holding Clip. Journal of Indian Orthodontic Society. 2020;54(2):157-160. doi:10.1177/0301574219884549 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Pattanaik S. Management of a Skeletal Class II Malocclusion Using 2-Phase Treatment: An Indian Board of Orthodontics Case Report. Journal of Indian Orthodontic Society. 2020;54(3):240-247. doi:10.1177/0301574220947551 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Bhattacharya A, Trivedi R, Parekh H, Mehta F, Patel R, Tyagi V. A Combined Orthodontic and Surgical Treatment Approach to Treat Vertically Diverse Skeletal Class II Malocclusions: A Case Series. Journal of Indian Orthodontic Society. 2020;54(3):248-259. doi:10.1177/0301574220905171 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Garabadu A, Chalasani S. “A”—Safe Way to Orthodontic Practice During COVID Times. Journal of Indian Orthodontic Society. 2020;54(3):260-261. doi:10.1177/0301574220947542 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Thakkar D, Ghosh A, Keshwani T. Digital Workflow for CBCT-Guided Customized Miniscrew-Assisted Rapid Palatal Expansion (3D Digital MARPE): A Clinical Innovation. Journal of Indian Orthodontic Society. 2020;54(3):262-266. doi:10.1177/0301574220926690 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Sangamesh B. Multistage Treatment of a Class II Division 1 Malocclusion With Severe Crowding. Journal of Indian Orthodontic Society. 2020;54(4):366-373. doi:10.1177/0301574220965684 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Banker AM, Muchhadia RP, Desai BB, Shah PA. Long-Term Results of a Modified Removable Expansion Plate to Increase Arch Length: A Series of 10 Cases. Journal of Indian Orthodontic Society. 2020;54(4):374-381. doi:10.1177/0301574220939493 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Mahendra TVD, Mulakala V. An Innovative Lingual Retainer Wire Stabilizer. Journal of Indian Orthodontic Society. 2020;54(4):382-383. doi:10.1177/0301574220941492 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Raju A, S M, Shetty B, Gopinath S. Correction of Relapsed Midline Diastema. Journal of Indian Orthodontic Society. 2020;54(4):384-385. doi:10.1177/0301574220924010 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Chauhan D, Datana S, Govindraj V. Model Surgery Simplified with the Use of Old Radiographic Films. Journal of Indian Orthodontic Society. 2020;54(4):386-388. doi:10.1177/0301574220950084 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Kohli SS, Singh Kohli V. Management of Bilaterally Impacted Labial and Palatal Maxillary Canines With One-Year Follow-Up: A Case Report. Journal of Indian Orthodontic Society. 2021;55(1):73-84. doi:10.1177/0301574220965307 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Parveen S, Mascarenhas R. Management of Skeletal Class II in a Growing Patient Using a Headgear and a Fixed Functional Appliance, with a Three-Year Follow-up : An Indian Board of Orthodontics Case Report. Journal of Indian Orthodontic Society. 2021;55(1):85-91. doi:10.1177/0301574220986247 Statement of Informed Consent: Written informed consent was obtained from the subject for the use of photographs for publication. Ram RR, Ranganayakulu I, K AV. Mathieu Forceps: A Learners Aid for Positioning the Weldable Molar Tube. Journal of Indian Orthodontic Society. 2021;55(1):92-93. doi:10.1177/0301574220952963 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used. Gopalakrishnan S, Chacko T, Jacob J. Management of Lip Biting Using Clear Aligner/Clear Retainer. Journal of Indian Orthodontic Society. 2021;55(1):94-95. doi:10.1177/0301574220964897 Statement of Informed Consent: Informed consent was not sought for the present study because no identifiable images were used.