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Auteur : Grafiati

Publié le 11 mars 2023

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1

_, _. « Re : Clin Invest Med. 2003 Feb;26(1):38-44 ». Clinical & ; Investigative Medicine 35, n^o 2 (1 avril 2012) : 45. http://dx.doi.org/10.25011/cim.v35i2.16286.

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Clinical and Investigative Medicine wishes to inform its readers of the following incident of redundant publication. The publication: Kang AK, Miller JA. Impact of gender on renal disease: the role of the renin angiotensin system. Clin Invest Med. 2003 Feb;26(1):38-44, contains a substantial amount of information and text reported in the previously published article, Kang AK, Miller JA. Effects of gender on the renin-angiotensin system, blood pressure, and renal function. Curr Hypertens Rep. 2002 Apr;4(2):143-51.

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Ammer, Stefanie, Christian Lambertz et Matthias Gauly. « Comparison of different measuring methods for body temperature in lactating cows under different climatic conditions ». Journal of Dairy Research 83, n^o 2 (mai 2016) : 165–72. http://dx.doi.org/10.1017/s0022029916000182.

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The aim of the research described here was to compare different methods of body temperature (BT) measurements in dairy cows. It was hypothesised that reticular temperature (RET) values reflect the physiological status of the animals in an equivalent way to rectal (RT) and vaginal (VT) measurements. RT, VT and RET temperatures of twelve lactating Holstein–Friesian cows were measured over five consecutive days in June and October 2013. While RT and VT were manually measured three times a day, RET was automatically recorded at 10 min intervals using a bolus in the reticulum. For comparison with RT and VT, different RET values were used: single values at the respective recording times (RET-SIN), and mean (RET-MEAN) and median (RET-MED) values of 2 h prior to RT and VT measurements. Overall, body temperatures averaged 38·1 ± 0·6, 38·2 ± 0·4, 38·7 ± 0·9, 38·5 ± 0·7 and 38·7 ± 0·5 °C for RT, VT, RET-SIN, RET-MEAN and RET-MED, respectively. RT and VT were lower than all RET measurements, while RET-SIN and RET-MED were higher than RET-MEAN (P < 0·001). RET-MEAN and RET-MED values were higher in the morning, whereas RT and VT were greatest in the evening (P < 0·001). Overall, records of RT and VT were strongly correlated (r = 0·75; P < 0·001). In contrast to RET-SIN and RET-MEAN, RET-MED was higher correlated to RT and VT. In June, coefficients were higher between all methods than in October. Relation of barn T to RT and VT was stronger when compared to RET measurements. RET-SIN was higher correlated to barn T than RET-MEAN or RET-MED. Correlation between VT and barn T was strongest (r = 0·48; P < 0·001). In summary, RET-MED showed highest correlation with VT and RT. However, single RET measurements (influenced by water or feed intake) can lead to extreme variations and differences to single VT and RT values.

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-. « Abstract From Current Literature Vol. 53 (1-2) ». Bangladesh Medical Journal Khulna 53, n^o 1-2 (18 juillet 2021) : 35–38. http://dx.doi.org/10.3329/bmjk.v53i1-2.54888.

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Islam, S. « An elegy for Dr Sajia - Dont we need more than a gentle societal push to end violence against women ? » Bangladesh Medical Journal 42, n^o 1 (26 mai 2014) : 38. http://dx.doi.org/10.3329/bmj.v42i1.18980.

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Datta, PG, KL Saha, JS Roy, AK Biswas et PP Das. « Congenital absence of one tonsil without any other congenital abnormality : a rare presentation ». Bangladesh Medical Research Council Bulletin 38, n^o 1 (22 avril 2012) : 39–40. http://dx.doi.org/10.3329/bmrcb.v38i1.10451.

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Kabir, AL, NM Irshadullah, A. Aziz, M. Begum et F. Rahman. « Back Pain : An Unusual Presentation of Castlemans Diseases ». Bangladesh Medical Research Council Bulletin 38, n^o 1 (22 avril 2012) : 40–41. http://dx.doi.org/10.3329/bmrcb.v38i1.10452.

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Rana, AQ. « Constipation presenting compliant and clinical marker of Parkinsons disease ». Bangladesh Medical Research Council Bulletin 38, n^o 1 (22 avril 2012) : 41–42. http://dx.doi.org/10.3329/bmrcb.v38i1.10453.

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Banik, Shibani, et Fahima Aktar. « Diameter of Renal Corpuscles of Bangladeshi People in Different Age Groups ». Journal of Enam Medical College 4, n^o 1 (23 février 2014) : 36–38. http://dx.doi.org/10.3329/jemc.v4i1.18067.

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Kutubi, Afroza. « Professionalism in Medical Practice ». Journal of Shaheed Suhrawardy Medical College 8, n^o 2 (5 juillet 2018) : 37–38. http://dx.doi.org/10.3329/jssmc.v8i2.37240.

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Burdge, Graham, et Karen Lillycrop. « Comment on Unterberger et al. J Med Primatol 38 (2009) 219-227 ». Journal of Medical Primatology 38, n^o 6 (décembre 2009) : 455–56. http://dx.doi.org/10.1111/j.1600-0684.2009.00388.x.

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Khan, MR, MA Aziz, MSU Shah et H. Imam. « Letter to the Editor ». Bangladesh Medical Research Council Bulletin 38, n^o 2 (9 décembre 2012) : 72–73. http://dx.doi.org/10.3329/bmrcb.v38i2.12886.

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Rashid, MA. « Interventional Physiatry : Need of the Day ». Journal of Shaheed Suhrawardy Medical College 4, n^o 2 (2 avril 2013) : 38. http://dx.doi.org/10.3329/jssmc.v4i2.14398.

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Editor, The. « Abstracts from Current Literature Vol.45(1-2) ». Bangladesh Medical Journal Khulna 45, n^o 1-2 (4 février 2013) : 38–41. http://dx.doi.org/10.3329/bmjk.v45i1-2.13630.

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Wells, Daniel R., Shelley Ost, Michael Kleinman et Natascha Thompson. « 38. PREDICTORS OF PASSING BOARD CERTIFICATION EXAMS IN A MED/PEDS RESIDENCY PROGRAM ». Academic Pediatrics 19, n^o 6 (août 2019) : e18-e19. http://dx.doi.org/10.1016/j.acap.2019.05.052.

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Bundsgaard, Anna Maj, et Vibeke Bliksted. « Socialkognitiv testning af raske danske voksne i alderen 20-38 år ». Psyke & ; Logos 40, n^o 2 (16 décembre 2019) : 53–68. http://dx.doi.org/10.7146/pl.v40i2.117806.

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I artiklen rapporteres resultater fra et studie, hvis formål var a) at undersøge, hvordan raske danske voksne præsterer på udvalgte socialkognitive tests (TASIT, Animerede Trekanter, Brünes Billedordning), og b) at undersøge det potentielle socialkognitive indhold i to kognitive tests (Billedordning WAIS-III og Familiebilleder WMS-III), der begge har gode danske normer i form af mange besvarelser fra forskellige aldersgrupper, som er repræsentative for den almindelige danske befolkning. 46 raske danske voksne i alderen 20-38 år gennemførte et omfattende testbatteri. Resultaterne viste, at de socialkognitive tests havde meget forskellige psykometriske egenskaber, herunder havde nogle alvorlige problemer med loftseffekt. Billedordning og Familiebilleder havde derimod gode psykometriske egenskaber med fin spredning i deltagernes besvarelser. Vi fandt ingen kønsforskelle i testene. En principal komponentanalyse, Principal Component Analysis (PCA),viste en korrelation mellem de to billedordningstest, hvorimod Familiebilleder korrelerede med de “oprigtige” filmklip fra TASIT. På baggrund af resultaterne fra dette studie kan især Billedordningstesten fra WAIS-III anses for at være en lovende kandidat som socialkognitiv test med gode danske normer. Der er dog stadig behov for mere forskning på området.

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Hofslundengen, Hilde, Sigrid Bøyum et Kjersti Sandnes Haukedal. « Betydningen av språkmiljøet hjemme for barnehagebarns andrespråklæring ». BARN - Forskning om barn og barndom i Norden 38, n^o 1 (7 mai 2020) : 23–38. http://dx.doi.org/10.5324/barn.v38i1.3576.

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Hensikten med studien var å undersøke sammenhenger mellom språklige hjemmemiljø og flerspråkligebarnehagebarns andrespråkferdigheter. Utvalget bestod av 71 barn med norsk somandrespråk (gjennomsnittsalder: 5,2 år; 33 jenter og 38 gutter). Språklig hjemmemiljø ble undersøktmed spørreskjema til foreldrene, mens andrespråkferdighetene ble undersøkt ved hjelp av ettestbatteri. Resultatene viste signifikante sammenhenger mellom andrespråkvokabular, narrativeferdigheter og fonembevissthet. Det var stor variasjon i hvor mye foreldrene leste for barna oghvor mange barnebøker de hadde hjemme. I halvparten av hjemmene leste de høyt på beggespråk, noe som hadde signifikant positiv sammenheng med barnas andrespråkvokabular og fonembevissthet.Foreldrenes utdanning hadde sammenheng med tid til høytlesing og antall barnebøkerpå førstespråket. Barnas alder, men ikke kjønn, korrelerte med andrespråkferdighetene.Samlet viser resultatene at høytlesing hjemme påvirker fonembevissthet, men at det som sterkestpredikerte barnas andrespråkferdigheter var hvor lenge barna hadde gått i barnehage.

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Author, No. « March Of Medicine ». Journal of Nepal Medical Association 3, n^o 1 (1 janvier 2003) : 39–44. http://dx.doi.org/10.31729/jnma.925.

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Report on Long-term Anticoagulant Therapy to the M.R.C. (1964) Brit. med. J.,1964, 2, 837Discoloration of Primary Dentition after Tetracycline Therapy In Pregnancy. Swallow. J.N. Lancet 1964, 2, 611Undernutrition in Infancy and Intellectual Development. Stoch M.B. & Smythe P.M. Arch. Dis. Childh., 1963, 38, 546.Oral Polio Vaccine Communications. JAMA, 1964. 190:41.Tetanus Prophylaxis. Cox. C. A., Knowelden.J. & Sharrard. W.J.H. Brit. med. J., 1963, 2, 1360.Eight Years' Experience with Oral Contraception. Tyler. E. T. Brit. med. J. 1964, 2, 843.Drug induced Blood Dyscrasias. JAMA, 1964. 188 :817 JAMA, 1964. 188: 531.

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Zaleski, Michael P., Mylene Truong et Cesar A. Moran. « Primary mediastinal chondrosarcomas : do they really exist ? » Mediastinum 4 (septembre 2020) : 24. http://dx.doi.org/10.21037/med-20-38.

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ONG, M., et S. GLANTZ. « Cardiovascular health and economic effects of smoke-free workplacesAm J Med. 2004;117:32-38 ». American Journal of Medicine 117, n^o 4 (15 août 2004) : 286. http://dx.doi.org/10.1016/s0002-9343(04)00427-9.

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Yartsev, Slav, et Thomas Rockwell Mackie. « Comment on “When is better best ? A multiobjective perspective” [Med. Phys. 38, 1635-1640 (2011)] ». Medical Physics 40, n^o 7 (17 juin 2013) : 077101. http://dx.doi.org/10.1118/1.4811106.

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Skalmerås, Maia Muri, Eirin Ellingbø et Albertina Rusandu. « Valg av modalitet ved karundersøkelser : CTA vs. MRA ». Radiography Open 7, n^o 1 (31 décembre 2021) : 34–53. http://dx.doi.org/10.7577/radopen.4605.

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Keywords: MRA, CTA, Modality choice, Angiographic imaging, Mixed method Sammendrag Hensikt Hensikten med denne studien var å undersøke hva som legges til grunn for radiologens valg av modalitet ved karundersøkelser. Dette med hensyn til at radiografen, med ansvar for berettigelse og selvstendig utførelse på CTA og MRA, bør kjenne til begrunnelsen for valgt modalitet. Metode Denne mixed method-studien bestod av en spørreundersøkelse med et nasjonalt perspektiv og et litteratursøk med et globalt perspektiv. Spørreundersøkelsen ble sendt til radiologer på offentlige sykehus i Norge. Litteratursøk ble gjennomført i databasene PubMed, Web of Science og Scopus, med søkeordene “MRA and CTA”, “MRA vs CTA” og “MRA and CTA and decision”. Resultat 38 respondenter deltok i undersøkelsen, og 21 studier ble inkludert fra litteratursøket. I resultatet kom det frem flere viktige faktorer som påvirker valg av modalitet, blant annet tilgjengelighet, pasientens situasjon, bildekvalitet og diagnostisk verdi. Noen viktig funn er at modalitetsvalg avhenger av patologi og dens lokalisasjon, samt at det i stor grad tas hensyn til ønske fra den som henviser. Konklusjon Valg av modalitet er hovedsakelig basert på klinisk problemstilling og pasientrelaterte faktorer. Faktorer knyttet til selve modaliteten som strålingsbelastning, undersøkelseshastighet, tilgjengelighet, er også tatt i betraktning, men foretrukken modalitet vil endres i takt med teknologiutvikling. Det kan sess et behov for retningslinjer for å øke radiografens kompetanse.

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Radin, Rachel M., Elissa S. Epel, Ashley E. Mason, Julie Vaccaro, Elena Fromer, Joanna Guan et Aric A. Prather. « Impact of digital meditation on work stress and health outcomes among adults with overweight : A randomized controlled trial ». PLOS ONE 18, n^o 3 (1 mars 2023) : e0280808. http://dx.doi.org/10.1371/journal.pone.0280808.

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Mindfulness meditation may improve well-being at work; however, effects on food cravings and metabolic health are not well known. We tested effects of digital meditation, alone or in combination with a healthy eating program, on perceived stress, cravings, and adiposity. We randomized 161 participants with overweight and moderate stress to digital meditation (‘MED,’ n = 38), digital meditation + healthy eating (‘MED+HE,’ n = 40), active control (‘HE,’ n = 41), or waitlist control (‘WL,’ n = 42) for 8 weeks. Participants (n = 145; M(SD) BMI: 30.8 (5.4) kg/m2) completed baseline and 8-week measures of stress (Perceived Stress Scale), cravings (Food Acceptance and Awareness Questionnaire) and adiposity (sagittal diameter and BMI). ANCOVAs revealed that those randomized to MED or MED+HE (vs. HE or WL) showed decreases in perceived stress (F = 15.19, p < .001, η2 = .10) and sagittal diameter (F = 4.59, p = .03, η2 = .04), with no differences in cravings or BMI. Those high in binge eating who received MED or MED+HE showed decreases in sagittal diameter (p = .03). Those with greater adherence to MED or MED+HE had greater reductions in stress, cravings, and adiposity (ps < .05). A brief digital mindfulness-based program is a low-cost method for reducing perceptions of stress and improving abdominal fat distribution patterns among adults with overweight and moderate stress. Future work should seek to clarify mechanisms by which such interventions contribute to improvements in health. Trial registration: Clinical trial registration http://www.ClinicalTrials.gov: identifier NCT03945214.

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Øines, Anne Marie. « De viktige bildebokvalgene – lesing av bildebøker som estetisk aktivitet i 38 barnehager ». BARN - Forskning om barn og barndom i Norden 37, n^o 2 (19 juin 2019) : 25–38. http://dx.doi.org/10.5324/barn.v37i2.3093.

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Denne artikkelen omhandler et utviklingsarbeid som involverte 38 barnehager. Et av målene med arbeidetvar at barnehagene skulle få økt kompetanse om nye bildebøker. Et annet var at de skulle få øktkunnskap, og forståelse for verdien av lesing som en estetisk aktivitet. Fokuset for denne teksten harvært å se på i hvilken grad bokutvalget, og kvalitetskriteriene for hva som er gode bildebøker har endretseg blant de ansatte etter deltakelse i prosjektet. En av endringene ser ut til å være at pedagogeneoftere enn før velger bildebøker av nyere dato; en annen endring er at barnehagelærerne oftere leserkomplekse bildebøker med et tolkningspotensiale i seg. Materialet viser at begge disse endringenehar ført til større leselyst blant barna. En tredje endring ser ut til å være at bokutvalget har endret segfra et tilfeldig til et gjennomtenkt og faglig begrunnet utvalg.

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O'Brien, Cara, Evan Henricks, Angela Beckert, Kathryn Denson et Edmund Duthie. « An 18-year Experience with an Innovative Geriatrics Training Model : Implications for the Workforce ». Innovation in Aging 5, Supplement_1 (1 décembre 2021) : 757–58. http://dx.doi.org/10.1093/geroni/igab046.2808.

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Abstract Despite the growing population of older adults, the geriatrics workforce has not similarly expanded. The number of geriatrics fellows has declined by 14.3% from 2012-2017. Implementation of innovative training programs may improve this reality. In 2002, the Medical College of Wisconsin (MCW) created the first four-year combined medicine residency and geriatrics fellowship (Med-Ger). Similar programs are currently being developed. The aim of this study is to describe the outcomes of the MCW Med-Ger program. Primary endpoints: American Board of Internal Medicine (ABIM) pass rates, ABIM Geriatric Medicine Certification pass rates, fellowship completion rates, and geriatric-focused practice. Results: There was a Med-Ger program fill rate of 73.7% (n=38). There was equivalent ABIM pass rate of 100% between Med-Ger graduates (n=18) and traditional graduates (n=25). Med-Ger trainees were more likely to complete their geriatrics fellowship (94.4% vs. 88%) and practice in geriatric-focused careers (82.4% vs. 68.2%). These outcomes suggest the benefit of a combined program for training future geriatricians. The MCW Med-Ger fill rate exceeds the national geriatrics fellowship fill rate of under 50%. Additionally, graduates may be more likely to practice geriatric medicine. This may help address population needs for an increased geriatrics workforce. In 2020, the ACGME approved an Advancing Innovation in Residency Education (AIRE) Medicine-Geriatrics Integrated Residency and Fellowship national pilot program. Further investigation of why trainees choose Med-Ger training and are more likely to continue with careers in geriatrics is needed in order to replicate the success of the MCW Med-Ger program.

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Li, Xinhua, Da Zhang et Bob Liu. « Comment on “In-patient to isocenter KERMA ratios in CT” [Med. Phys. 38, 5362-5369 (2011)] ». Medical Physics 38, n^o 12 (1 décembre 2011) : 6787–88. http://dx.doi.org/10.1118/1.3663667.

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Phillips, Mark, Clay Holdsworth, Ira Kalet, Wade Smith, Minsun Kim et Juergen Meyer. « Response to “Comment on ‘When is better best ? A multiobjective perspective’” [Med. Phys. 38, 1635-1640 (2011)] ». Medical Physics 40, n^o 7 (27 juin 2013) : 077102. http://dx.doi.org/10.1118/1.4811107.

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Pemmaraju, Naveen, Deborah A. Thomas, Hagop Kantarjian, Susan Mary O'Brien, Naval Guastad Daver, Aziz Nazha, Sherry Pierce, Guillermo Garcia-Manero, Jorge E. Cortes et Stefan Faderl. « Analysis of outcomes of patients (pts) with blastic plasmacytoid dendritic cell neoplasm (BPDCN). » Journal of Clinical Oncology 30, n^o 15_suppl (20 mai 2012) : 6578. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6578.

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6578 Background: BPDCN, formerly known as CD4 + CD56 + hematodermic tumor or blastic NK cell lymphoma, is a rare and aggressive hematologic malignancy. Little is known about outcomes of pts with BPDCN. Methods: We conducted a retrospective review of pts meeting following criteria: pathological diagnosis of BPDCN confirmed by an experienced hematopathologist and age ≥ 18. Results: 13 pts, diagnosed October 1998-July 2011, were identified. Median (med) age: 62 years (range 20-86 years), 12 (92%) were male. Bone marrow (BM) involved in 9 (69%), skin 8 (62%), lymph nodes 5 (38%), brain 1 and uterine/ovarian 1 pt. Immunophenotype by flow cytometry: CD4+ (11/11 pts), CD56+ (10/11 pts), TCL-1+ (4/4 pts). Karyotype (8 pts): del(12) (1pt), complex (2), and diploid (5). Med CBC: WBC 5.8 x 109/L (1.7-76.5), Hb 12.3 g/dL (8.3-17.0), platelet 107 x 109/L (44-255). Med BM blasts: 22% (0-77). 10 pts received first-line therapy with Hyper-CVAD alternating with high-dose methotrexate(MTX) and cytarabine (HCVAD) (in 1 pt following one cycle of CHOP), CHOP (2), oral MTX (1). Med follow-up time: 9 months (mo) (2-14 mo). Med number chemotherapy regimens: 1 (1-5). Complete remission (CR) in 10 pts. Med CR1: 19 mo (4-39 mo). Med overall survival (OS) 29 mo (1-44 mo). 9 pts have died, unknown cause (3), multi-organ failure (6). 10 pts received HCVAD as part of first line therapy: med OS: 29 mo (1-44 mo), med CR1: 21 mo (4-39 mo), 9/10 (90%) pts achieved CR1; 1 pt did not achieve CR1 (died, pneumonia, day 15). 9 pts (69%) had BM involvement (7 with other organs involved besides BM). 4 (31%) pts had no BM involvement; all 4 of these pts had skin involvement only. Med OS, med CR1 of pts with BM involvement: 23 mo (1-44mo), 22 mo (4-39mo), respectively. Med OS, med CR1 of skin only pts: 29 mo (2-31 mo), 7 mo (6-19 mo), respectively, p=not significant. 4 pts received stem cell transplant (SCT) (2 allogeneic ,2 autologous). Med OS for pts receiving SCT (n=4) was 31 mo(8-31 mo) versus med OS for non-SCT group (n=9) of 29 mo (1-44), p=not significant. Conclusions: Despite intensive multi-agent chemotherapy and SCT, response rates are low and survival is short. Better understanding of the biologic basis of this disease and novel treatment approaches for treatment of BPCDN are crucial.

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Skjenneberg, Sven. « Forord ved redaktøren og innholdsliste ». Rangifer 2, n^o 1-App (1 mars 2013) : i. http://dx.doi.org/10.7557/2.2.1-app.436.

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NORs arbeidsutvalg vedtok i møte i Helsingfors 25. februar 1981 at det første forskermøte i NORs regi skulle vies temaet ”Tap av rein”. Som sted for møtet ble valgt Hemavan i Sverige. Konferansen samlet 38 deltakere.Hovedhensikten med konferansen var:1. Få oversikt over tapenes omfang.2. Klarlegge status for den eksakte viten om tapsårsakene.3. Drøfte, eventuelt prioritere emner for fremtidige forskningsprosjekter innen temaet.

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Mortensen, Peter, Hao Gao, Godfrey Smith et Radostin D. Simitev. « Addendum : Action potential propagation and block in a model of atrial tissue with myocyte–fibroblast coupling ». Mathematical Medicine and Biology : A Journal of the IMA 38, n^o 3 (6 mai 2021) : 292–98. http://dx.doi.org/10.1093/imammb/dqab005.

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Abstract The analytical theory of our earlier study (Mortensen et al., 2021, Math. Med. Biol., 38, 106–131) is extended to address the outstanding cases of fibroblast barrier distribution and myocyte strait distribution. In particular, closed-form approximations to the resting membrane potential and to the critical parameter values for propagation are derived for these two non-uniform fibroblast distributions and are in good agreement with numerical estimates.

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Lal, Rayhan A., David M. Maahs, Chrysoula Dosiou, Tandy Aye et Marina Basina. « THE GUIDED TRANSFER OF CARE IMPROVES ADULT CLINIC SHOW RATE ». Endocrine Practice 26, n^o 5 (mai 2020) : 508–13. http://dx.doi.org/10.4158/ep-2019-0470.

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Objective: Every year, 500,000 youths in the U.S. with chronic disease turn 18 years of age and eventually require transfer to adult subspecialty care. Evidence-based interventions on the organization of transfer of care are limited, although engagement and retention in adult clinic are considered appropriate outcomes. Sustained continuity of care improves patient satisfaction and reduces hospitalization. Methods: We conducted a prospective, nonrandomized cohort study of patients with pediatric endocrine conditions, age 16 to 26 years, enrolled upon referral to the adult endocrine clinic of a physician trained in both adult and pediatric endocrinology (Med+Peds endocrinologist). Patients differed based on whether their referral originated from another pediatric endocrinologist (traditional transfer) or if the Med+Peds endocrinologist previously saw the patient in his pediatric endocrine clinic (guided transfer). Rather than relying on arbitrary age criteria, guided transfer to adult clinic occurred when physician and patient considered it appropriate. The primary outcome was show rate at the first and second adult visits. Results: Of 36 patients, 21 were referred by another pediatric endocrinologist and 15 underwent guided transfer. For traditional transfer, show rate to the first and second visit was 38%, compared to 100% in the guided transfer group ( P = .0001). Subgroup analysis of 27 patients with diabetes revealed that both groups had similar initial hemoglobin A1c ( P = .38), and the guided transfer group maintained hemoglobin A1c. Conclusion: Most traditional transfers were unsuccessful. Guided transfer was significantly more effective, with every patient successfully transferring, and could be implemented with adult endocrinologists willing to see patients in the pediatric clinic. Abbreviations: DKA = diabetic ketoacidosis; HbA1c = hemoglobin A1c; Med+Peds = Internal Medicine and Pediatrics

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Amado Garzón, Sandra, et Juan Sebastián Gómez Villalobos. « Empiema Necessitatis ». Acta Médica Colombiana 38, n^o 1 (29 avril 2013) : 28–31. http://dx.doi.org/10.36104/amc.2013.229.

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Se presenta el caso de un hombre de 73 años, agricultor, quien consulta por cuadro de tres meses de tos húmeda con expectoración verdosa, posteriormente hemoptoica, de predominio matutino, asociado a dolor lumbar izquierdo. Se documentó en imágenes empiema que se comunica con región lumbar izquierda, constituyendo así un cuadro de empiema necessitatis con presentación poco usual como lo es el drenaje hacia espacio paravertebral. (Acta Med Colomb 2013; 38: 28-31)

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Ogden, Kent, et Walter Huda. « Response to “Comment on ‘In-patient to isocenter KERMA ratios in CT’” [Med. Phys. 38, 5362-5369 (2010)] ». Medical Physics 39, n^o 1 (3 janvier 2012) : 562. http://dx.doi.org/10.1118/1.3663668.

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Zupan, Gregor. « Digitalni indeks slovenskih podjetij ». Uporabna informatika 25, n^o 4 (19 janvier 2018) : 11. http://dx.doi.org/10.31449/upinf.5.

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Digitalno preobraziti podjetje pomeni med drugim razviti s pomočjo digitalne tehnologije nove poslovne procese in modele, spremeniti organizacijo poslovanja. Namen digitalizacije je povezati med seboj posamezne poslovne procese, da bi ti potekali avtomatizirano, in to v vseh fazah: od prejema naročila, nabave materiala, proizvodnje do dostave končnega izdelka. Statistični urad Republike Slovenije (SURS) je pred izzivom, kako statistično spremljati digitalno preobrazbo slovenskih podjetij. V letnem statističnem raziskovanju Uporaba IKT v podjetjih z vsaj 10 zaposlenimi spremljamo številne kazalnike, ki z različnih vidikov kažejo razširjenost uporabe IKT v podjetjih, npr. delež zaposlenih, ki uporabljajo pri svojem delu računalnike, obseg spletne prodaje, koliko podjetij oglašuje na internetu ipd. Namen prispevka je prikazati, kako lahko te kazalnike, s katerimi spremljamo uporabo IKT, uporabimo za prikaz stopnje digitalizacije podjetij z vsaj desetimi zaposlenimi v Sloveniji. Lahko jo prikažemo z digitalnim indeksom, ki se izračunava na podlagi dvanajstih kazalnikov, s katerimi spremljamo uporabo IKT v podjetjih v posameznem letu. Leta 2016 je bilo med podjetji z vsaj desetimi zaposlenimi največ takih, ki so izkazovala »nizek« digitalni indeks (44 odstotkov); 38 odstotkov podjetij je izkazovalo »zelo nizek« digitalni indeks, 17 odstotkov »visok« digitalni indeks in 1 odstotek podjetij »zelo visok« digitalni indeks.

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Zupan, Gregor. « Digitalni indeks slovenskih podjetij ». Uporabna informatika 25, n^o 4 (19 janvier 2018) : 11. http://dx.doi.org/10.31449/upinf.vol25.num4.5.

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Digitalno preobraziti podjetje pomeni med drugim razviti s pomočjo digitalne tehnologije nove poslovne procese in modele, spremeniti organizacijo poslovanja. Namen digitalizacije je povezati med seboj posamezne poslovne procese, da bi ti potekali avtomatizirano, in to v vseh fazah: od prejema naročila, nabave materiala, proizvodnje do dostave končnega izdelka. Statistični urad Republike Slovenije (SURS) je pred izzivom, kako statistično spremljati digitalno preobrazbo slovenskih podjetij. V letnem statističnem raziskovanju Uporaba IKT v podjetjih z vsaj 10 zaposlenimi spremljamo številne kazalnike, ki z različnih vidikov kažejo razširjenost uporabe IKT v podjetjih, npr. delež zaposlenih, ki uporabljajo pri svojem delu računalnike, obseg spletne prodaje, koliko podjetij oglašuje na internetu ipd. Namen prispevka je prikazati, kako lahko te kazalnike, s katerimi spremljamo uporabo IKT, uporabimo za prikaz stopnje digitalizacije podjetij z vsaj desetimi zaposlenimi v Sloveniji. Lahko jo prikažemo z digitalnim indeksom, ki se izračunava na podlagi dvanajstih kazalnikov, s katerimi spremljamo uporabo IKT v podjetjih v posameznem letu. Leta 2016 je bilo med podjetji z vsaj desetimi zaposlenimi največ takih, ki so izkazovala »nizek« digitalni indeks (44 odstotkov); 38 odstotkov podjetij je izkazovalo »zelo nizek« digitalni indeks, 17 odstotkov »visok« digitalni indeks in 1 odstotek podjetij »zelo visok« digitalni indeks.

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Munmun, Salma Akter, Shiuly Chowdhury, Begum Nasrin, Rowson Ara et Nahida Parvin. « Precocious Puberty : A Case Report ». Ibrahim Cardiac Medical Journal 4, n^o 1 (5 décembre 2015) : 38–41. http://dx.doi.org/10.3329/icmj.v4i1.52872.

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A 4 years old girl was brought to the Department of Obstetrics and Gynaecology (of Bangabandhu Sheikh Mujib Medical University) for cyclical pervaginal bleeding and breast development. Her medical and family history was unremarkable. Evaluating her clinical presentations and investigations she was diagnosed as a case of precocious puberty. This case report emphasized how this condition should be evaluated and how these cases are to be managed. Ibrahim Cardiac Med J 2014; 4(1): 38-41

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Pacifico, Alessia, Rosalynn R. Z. Conic, Antonio Cristaudo, Sergio Garbarino, Marco Ardigò, Aldo Morrone, Paolo Iacovelli et al. « Diet-Related Phototoxic Reactions in Psoriatic Patients Undergoing Phototherapy : Results from a Multicenter Prospective Study ». Nutrients 13, n^o 9 (25 août 2021) : 2934. http://dx.doi.org/10.3390/nu13092934.

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Vegans and vegetarians often consume foods containing photosensitizers capable of triggering phytophotodermatitis. The potential effect of vegan and vegetarian diets on the response of psoriatic patients undergoing phototherapy is not well characterized. We assessed clinical outcomes of vegan, vegetarian and omnivore adult psoriatic patients undergoing band ultraviolet B phototherapy (NB-UVB). In this multicenter prospective observational study, we enrolled 119 adult, psoriatic patients, of whom 40 were omnivores, 41 were vegetarians and 38 were vegans, with phototherapy indication. After determining the minimum erythemal dose (MED), we performed NB-UVB sessions for 8 weeks. The first irradiation dosage was 70.00% of the MED, then increased by 20.00% (no erythema) or by 10.00% (presence of erythema) until a maximum single dose of 3 J/cm2 was reached and constantly maintained. All the enrolled patients completed the 8 weeks of therapy. Severe erythema was present in 16 (42.11%) vegans, 7 (17.07%) vegetarians and 4 (10.00%) omnivores (p < 0.01). MED was lowest among vegans (21.18 ± 4.85 J/m2), followed by vegetarians (28.90 ± 6.66 J/m2) and omnivores (33.63 ± 4.53 J/m2, p < 0.01). Patients with severe erythema were more likely to have a high furocumarin intake (OR 5.67, 95% CI 3.74–8.61, p < 0.01). Vegans consumed the highest amount of furocumarin-rich foods. A model examining erythema, adjusted for gender, age, skin type, MED, phototherapy type, number of phototherapies and furocumarin intake, confirmed that vegans had a lower number of treatments. Vegans had more frequent severe erythema from NB-UVB, even after adjustment of the phototherapy protocol for their lower MED. Assessing diet information and adapting the protocol for vegan patients may be prudent.

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Lundberg, Helge Einar, Helge Holo, Trond Holand, Hans E. Fagertun et Stig Larsen. « Determination of maintenance Jarlsberg® cheese dose to keep the obtained serum osteocalcin level ; a response surface pathway designed de-escalation dose study with individual starting values ». International Journal of Clinical Trials 8, n^o 3 (22 juillet 2021) : 174. http://dx.doi.org/10.18203/2349-3259.ijct20212841.

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<p class="abstract"><strong>Background:</strong> Daily maximum effective dose (MED) of Jarlsberg® increased the serum osteocalcin (tOC) level, vitamin K2 and affected the lipid pattern positively. The aim of the study was to estimate and verify a daily maintenance dose.</p><p class="abstract"><strong>Methods:</strong> 12 healthy female volunteers (HV) were included in a de-escalation study after a six week run-in period on the daily MED of 57 g Jarlsberg® cheese. A 3-level within-patient response surface pathway (RSP) design with individual starting values was developed. Another 12 HVs were included in a new study with a six week run-in period on MED followed with six weeks on the estimated maintenance dose. All HVs were premenopausal female between 20 and 52 years of age. The main variable in the studies was the tOC level.</p><p class="abstract"><strong>Results:</strong> tOC, cOC and the vitamin K2 variants increases significantly (p<0.01) during the run-in period on daily MED of Jarlsberg® in both studies. The maintenance daily dose was estimated to 45 g (95% CI: 38-52 g/day) and used in the new study. The tOC level was reduced from 19.8 ng/ml (95% CI: 12.0-27.6) obtained in the run-in period to 18.5 ng/ml (95% CI: 11.7-25.3) during the maintenance part. This represents a reduction of 6.6%. The sum of vitamin K2 variants changed from 0.58 ng/ml on MED of Jarlsberg® to 0.59 ng/ml (95% CI: 0.37-0.82) during the maintenance period.</p><p class="abstract"><strong>Conclusions: </strong>Daily MED of Jarlsberg® cheese increases tOC, cOC and the vitamin K2 level. The maintenance Jarlsberg® dose was estimated to 45 g/day and verified as sufficient.</p>

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Mojumdar, Sumon Kanti, Md Nazrul Islam, Abul Khair Ahmedullah, Md Abu Shahin et Md Masudul Hassan. « Leflunamide Induced Pneumonitis in Rheumatoid Arthritis - A Case Report and Review of Literature ». Bangladesh Medical Journal 46, n^o 1 (21 novembre 2017) : 38–40. http://dx.doi.org/10.3329/bmj.v46i1.34638.

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A 51 year old woman while treated on methotrexate (MTX) and leflunomide (LEF) for rheumatoid arthritis (RA), developed exertional breathlessness and undue tiredness followed by fever and cough, at her 11 years of suffering. Her respiratory symptoms developed around 12 weeks after leflunomide intake. She improved with steroid treatment. The Leflunomide (LEF) induced interstitial pneumonitis is an uncommon condition in absence of prior lung disease but potentially fatal. We report a case of Leflunomide (LEF) induced interstitial pneumonitis.Bangladesh Med J. 2017 Jan; 46 (1): 38-40

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Fisher, Allan H. « American Podiatric Medical Association Missing Time Survey, 2004 ». Journal of the American Podiatric Medical Association 94, n^o 6 (1 novembre 2004) : 604–7. http://dx.doi.org/10.7547/0940604.

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A 2004 survey of US adults found that 19% had experienced foot problems at work at some time. As a result, 38% reported lost productivity and 28% missed time at work. Younger, less educated male workers were more likely to suffer from foot problems. The percentage of the total population surveyed who missed time at work owing to foot problems was 5.4% in 2004. In a previous survey conducted in 2000, the corresponding percentage was 6.6%. (J Am Podiatr Med Assoc 94(6): 604–607, 2004)

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Bhowmik, Devolina, Md Ruhul Amin Miah, Shirin Tarafder, Ahmed Abu Saleh et Manash Chandra Sarker. « Distribution of HLA-B Locus Antigens in Patients with Psoriatic Arthritis in Bangladesh ». Bangladesh Journal of Medical Microbiology 12, n^o 2 (16 août 2018) : 14–20. http://dx.doi.org/10.3329/bjmm.v12i2.51691.

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This study was designed to investigate the distribution of HLA-B locus antigens in patients with psoriatic arthritis (PsA) in Bangladesh and identify HLA markers related to disease manifestation in PsA. HLA-B typing was carried out by polymerase chain reaction (PCR) with sequence specific primers in a group of 50 consecutive PsA patients. The reports of HLA-B locus antigens typing were collected from 50 ages and sex matched unrelated healthy donors as controls. A total of 17 HLA-B locus antigens were determined in both patients and controls. The most common antigen was B*15 (34%) followed by B*07 (26%), B*27 (24%), B*38 (20%). Human leukocyte antigens B*07, B*27 and B*38 alleles were found to be significantly prevalent in PsA patients compared with healthy controls. We found a statistically significant association between spondylitis pattern and the presence of HLA-B*27. PsA in Bangladeshi patients seems to be associated with the presence of B*07, B*27 and B*38 alleles. Bangladesh J Med Microbiol 2018; 12 (2): 14-20

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Ibrahim, N. K., G. Nguyen, D. Suki, B. Hennessy, A. Montero, J. E. Sarriera, F. Symmans, V. Valero, R. Sawaya et K. Aldape. « Clinicopathological correlation (CC) and outcome of breast cancer patients (pts) with resected brain metastasis (BM) ». Journal of Clinical Oncology 24, n^o 18_suppl (20 juin 2006) : 656. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.656.

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656 Background: We aimed at determining the pathologic features of metastatic breast lesions to the brain, and their correlation with the primary tumor, and their effect on postneurosurgical survival (PNS). Methods: Tissue samples from 123 pts who underwent surgical resection of BM at MDACC between 1984–2004, were examined for estrogen receptor-α (ER) by IHC and HER2 by FISH or IHC. Pts’ medical records were retrospectively reviewed for CC. Results: Median (med) age at BM diagnosis was 51 years. The med time from primary diagnosis to BM was 33 months (Range (R)0–304). Infiltrating ductal cancers were found in 89%. ER was negative and HER2 amplified in 73% and 37% of BM, respectively; ER-/Her2- was seen in 43%, ER-/Her2+ in 30%, ER+/Her2+ in 6%. Concordance of ER and HER2 status between primary and BM were both 88% (p=NS, for discordance). ER positivity was associated with a longer primary diagnosis to BM interval [med 39 months (R, 0–213) vs. 29 months (R, 0–304) in the ER- pts; p=0.02]; HER2 amplification was not (p=0.82). The med PNS was 11.2 months (R, 9.0–13.5) for 112 pts with no pre- craniotomy brain radiation. Pts with ER+ metastases experienced apparent longer PNS survival than ER- pts [med 18.9 months (95% CI, 4.8–33.1) vs. 9.9 months (95% CI, 7.6–12.1 months), respectively, p=0.06], as did those with HER2-amplified BM [med 13.8 months vs. 9.9 months, respectively; p=0.10]. Pts aged 45 to <60 years had significantly longer pns survival (med 15.5 months) than younger or older pts (med 9.5 and 5.1 months, respectively), p≤.05 for all pair- wise comparisons. In mutivariate analyses correcting for age, functional status, and systemic tumor burden, neither ER nor HER2 status were independent predictors of pns. Of the 38 patients with HER2-amplified tumors and no pre- craniotomy radiation, 14 received trastuzumab (Tz) prior to initial neurosurgery. These 14 pts had longer PNS compared to those with HER2-amplified tumors not receiving Tz [median, 25.4 months vs. 10.7 months, respectively, p=NS). Conclusions: ER and HER2 positivity were highly concordant between primary and BM. Resected BM were more likely to be ER- or HER2-amplified. ER positivity and HER2 amplification were not significant independent predictors of PNS, though both showed a strong trend in univariate analyses. Middle age group pts had the best PNS survival. No significant financial relationships to disclose.

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Fiedler, Erik Sporon. « Processioner i Nürnberg : De nationalsocialistiske rigspartidage under Det Tredje Rige, 1933-38 ». Religionsvidenskabeligt Tidsskrift, n^o 66 (15 juin 2017) : 182. http://dx.doi.org/10.7146/rt.v0i66.26455.

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English abstract: The Nuremberg Party Rallies of the National Socialists are arguably the most important events on the special liturgical calendar of the Nazi-movement. A lot of the phenomena that make the Nazi movement a political religion are present at the rallies. The aim of this article is to give a thorough historical description of the events, especially the rallies that took place between 1933 and 1938, and to place them in a context where their significance to the study of religion becomes clear. The article begins with a brief discussion of the concept of political religion, and a historical account of the rallies is then given. Finally, the article considers the special relevance of the processions held during the rallies.Dansk resume: De nazistiske partikongresser, der blev afholdt i Nürnberg, er formentlig den vigtigste begivenhed i den særlige nazistiske højtidskalender. På partidagene forekom mange af de ting, der gør, at nazismen ofte bliver betragtet en politisk religion. Sigtet med artiklen er at give en grundig historisk beskrivelse af begivenheden, særligt som den tog sig ud i perioden 1933-38, og at indplacere den i en kontekst, hvor den får religionsvidenskabelig relevans. Artiklen begynder med en kort diskussion af begrebet politisk religion, førend der gives en historisk redegørelse for partidagene. Afslutningsvis behandler artiklen den særlige betydning, de processioner har, der afholdtes under partidagene.

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Zaidi, SHH, et Preeti Agarwal. « Study of Supratrochlear Foramen of Humerus : A Morphometric Study ». International Journal of Advanced and Integrated Medical Sciences 2, n^o 1 (2017) : 8–10. http://dx.doi.org/10.5005/jp-journals-10050-10065.

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ABSTRACT This study is conducted to know the incidence of supratrochlear foramen and its morphometry. A total of 38 humerus bones are studied in the Indian population sample, in light of available literature, and clinical, racial, and regional significance is drawn, if present. Materials and methods Thirty-eight humerus bones belonging to the museum of the Department of Anatomy, Rohilkhand Medical College & Hospital, Bareilly, Uttar Pradesh, India, were studied to observe the incidence of supratrochlear foramen anomaly in the Indian population sample. Results The supratrochlear foramen anomaly was observed in 7 out of 38 humeri studied, i.e., 18.4%. Conclusion: The findings are of considerable clinical, racial, and regional significance, and are discussed. How to cite this article Agarwal P, Zaidi SHH. Study of Supratrochlear Foramen of Humerus: A Morphometric Study. Int J Adv Integ Med Sci 2017;2(1):8-10.

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Hossain, MM, MM Hossain, MH Muhib, MR Mia, S. Kumar et SA Wadud. « In vitro antioxidant potential study of some synthetic quinoxalines ». Bangladesh Medical Research Council Bulletin 38, n^o 2 (9 décembre 2012) : 47–50. http://dx.doi.org/10.3329/bmrcb.v38i2.12880.

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In continuation of our study the in vitro antioxidant activity of some novel quinoxaline derivatives was investigated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method with respect to ascorbic acid. To determine the antioxidant activity, a number of substituted indoxyls (3A-G), cyclic ketones (2A-G), and quinoxalines (1A-G) were synthesized by both microwave and conventional heating methods. The present findings revealed that some quinoxalines and their precursors (1D, 1F, 1G and 2E) exhibited a marked scavenging effect on DPPH radical. DOI: http://dx.doi.org/10.3329/bmrcb.v38i2.12880 Bangladesh Med Res Counc Bull 2012; 38: 47-50

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Kazhdan, Michael, Todd McNutt, Russell Taylor, Binbin Wu et Patricio Simari. « Comment on “A planning quality evaluation tool for prostate adaptive IMRT based on machine learning” [Med. Phys. 38, 719 (2011)] ». Medical Physics 38, n^o 5 (9 mai 2011) : 2820. http://dx.doi.org/10.1118/1.3578612.

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Fleming, Jennifer, Penny Kris-Etherton, Kristina Petersen et David Baer. « Effect of Mediterranean Diets with Varying Amounts of Lean Beef on Measures of Vascular Health ». Current Developments in Nutrition 4, Supplement_2 (29 mai 2020) : 521. http://dx.doi.org/10.1093/cdn/nzaa046_021.

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Abstract Objectives To evaluate the effects of Mediterranean (MED) diets with different quantities of lean beef (0.5, 2.5 and 5.5 oz/day) compared to an Average American diet (AAD) on brachial and central blood pressure, pulse wave velocity (PWV) and augmentation index (AI). Methods We conducted a multicenter, 4-period controlled feeding, randomized crossover study at Penn State University and USDA-Beltsville to evaluate the effects of MED diets (CHO 42%, PRO 17%, FAT 41%, SFA 8%, MUFA 26%, PUFA 8%) with different quantities of lean beef (0.5, 2.5 and 5.5 oz/day) compared to an average American diet (AAD; CHO 52%, PRO 15%, FAT 33%, SFA 12%, MUFA 13%, PUFA 8%) on vascular health. Participants (n = 66) included generally healthy males and females (BMI = 20–38 kg/m2) 30 to 67 years. Participants were randomized to each of the 4 diets for 4 weeks with an approximate 2-week break between treatments. Central blood pressure, PWV and AI were measured using the SphygmoCor ECEL-System. Endpoints were assessed at baseline and the end of each 4-week diet period. Results There was a significant treatment effect for PWV (P < 0.01); PWV was lower following consumption of the MED diets containing 0.5 oz. lean beef/day (6.86 m/sec ± 0.14; P < 0.05) and 2.5 oz. of lean beef/day (6.84 m/sec ± 0.15; P < 0.01) compared to the AAD (7.10 m/sec ± 0.14). Compared to the AAD, both the 0.5 oz./day (−3.30 mmHg ± 0.76) and 2.5 oz./day (−2.94 mmHg ± 0.76) MED diets elicited greater reductions in central systolic blood. A similar pattern was observed for central diastolic pressure. Compared to AAD, all three MED diets significantly decreased brachial systolic and diastolic pressures (P < 0.01 for all). Compared to baseline only the MED 0.5 elicited a significant reduction in AI (P < 0.01). Conclusions This study demonstrated improvements in measures of arterial stiffness and central blood pressure following Mediterranean diets containing low to moderate amounts of lean beef. Funding Sources National Cattleman's Beef Association, The Penn State Clinical and Translational Research Institute, Pennsylvania State University Clinical and Translational Science Award, and NIH/National Center for Advancing Translational Sciences grant no. UL1TR000127.

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Naher, Nurun, Laila Nurun Nahar, Sabina Sultana, Abdul Matin, Md Hasan Jamal Fakir et Md Rafiqul Islam. « Carnitine Palmitoyl Tranferase Type 1 Deficiency in Fatty acid oxidation disorder : A Case report ». Journal of Shaheed Suhrawardy Medical College 6, n^o 1 (7 mars 2017) : 38–40. http://dx.doi.org/10.3329/jssmc.v6i1.31491.

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Carnitine palmitoyltransferase 1(CPT-1) catalyzes the formation of acylcarnitine, which is the first step in the oxidation of long chain fatty acid in the mitochondria. CPT-1 deficiency is an inborn error of metabolism. Reported patient with CPT -1 deficiency was a 16 months old boy present with hypoketotic hypoglycaemia, hepatomegaly with raised liver transaminases, hyperamminaemia, convulsion and unconsciousness. Diagnosis was established by IMD panel study. Treatment was done by correction of hypoglycemia, avoidance of hypoglycemia by ensuring frequent feeding, avoidance of prolonged fasting, treatment of infection & other supportive measures.J Shaheed Suhrawardy Med Coll, June 2014, Vol.6(1); 38-40

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Abu-Rumman, Patricia L., David G. Armstrong et Brent P. Nixon. « Use of Clinical Laboratory Parameters to Evaluate Wound Healing Potential in Diabetes Mellitus ». Journal of the American Podiatric Medical Association 92, n^o 1 (1 janvier 2002) : 38–47. http://dx.doi.org/10.7547/87507315-92-1-38.

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Clinicians caring for chronic wounds can easily overlook nutritional status. Patients with diabetes are at high risk for primary and secondary malnutrition. Although profiles exist defining the extent of the deficiency, the process of wound healing and the interactions of the macronutrients and micronutrients necessary to accomplish it must first be understood. In elderly patients with diabetes, additional factors such as liver and renal function, the interdependence of the immune system, and protein synthesis, also must be considered. This article provides a practical format to assist clinicians in better evaluating this often difficult-to-assess area of care. (J Am Podiatr Med Assoc 92(1): 38-47, 2002)

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Romano, Dario, Valentino De Ruvo, Paolo Fogagnolo, Roberta Farci et Luca Mario Rossetti. « Inter-Eye Comparison of the Ocular Surface of Glaucoma Patients Receiving Surgical and Medical Treatments ». Journal of Clinical Medicine 11, n^o 5 (24 février 2022) : 1238. http://dx.doi.org/10.3390/jcm11051238.

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Background: Ocular surface frequently affects glaucoma patients. In this paper we aimed at evaluating the impact of glaucoma surgery on the ocular surface of patients who received unilateral trabeculectomy. Methods: 26 consecutive patients successfully treated with trabeculectomy on one eye (Trab Eye) and under control with topical treatments on the fellow eye (Med Eye) were included in this observational study. They received IDEEL and OSDI questionnaires, Tear Film Osmolarity (TFO), grading of conjunctival hyperemia, fluorescein tear break-up time (tBUT), grading of corneal staining and Schirmer test. Results: IDEEL and OSDI scores were 48 ± 38 and 11 ± 12, respectively, with moderate correlation (r = 0.50, p = 0.03). Compared with Med eyes, Trab Eyes had higher tBUT (6.5 ± 3.5 vs. 5.1 ± 2.7 s, p = 0.004), lower conjunctival hyperemia (0.8 ± 0.9 and 1.7 ± 1.1 respectively, p < 0.001) and lower corneal staining (0.3 ± 0.5 and 0.6 ± 0.5, respectively, p = 0.03). Correlation between corneal staining and conjunctival hyperemia was 0.55 in Trab Eyes (p = 0.01) and 0.44 in Med Eyes (p > 0.05). Patients with bilateral corneal staining had had threefold worse questionnaire scores (p < 0.05). The duration of treatment and the daily exposure to preservatives did not directly affect OS parameters in this cohort of patients. Conclusions: Patients receiving successful trabeculectomy showed better OS homeostasis (higher TBUT, lower grading of conjunctival hyperemia and corneal staining) than fellow medically treated eyes. Presence of corneal epithelial damage in both eyes is the factor more consistently affecting questionnaire scores.

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Polizzotto, Mark N., Thomas S. Uldrick, Victoria Wang, Karen Aleman, Kathleen M. Wyvill, Vickie Marshall, Stefania Pittaluga et al. « Distinct Human and Viral Interleukin-6 Profiles and Other Viral and Immunologic Abnormalities In KSHV-Associated Multicentric Castleman Disease : Relationship with Disease Activity and Individual Disease Manifestations ». Blood 118, n^o 21 (18 novembre 2011) : 1573. http://dx.doi.org/10.1182/blood.v118.21.1573.1573.

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Abstract Abstract 1573 Background: Multicentric Castleman disease (MCD) is a polyclonal B-cell lymphoproliferative disorder characterized by flares of severe inflammatory symptoms, including fever and cachexia, with cytopenias and biochemical abnormalities. In the idiopathic form, its pathogenesis is linked to overproduction of interleukin (IL)-6. A distinct form of MCD is caused by Kaposi sarcoma-associated herpesvirus (KSHV, also called human herpesvirus [HHV]-8). KSHV encodes a viral homolog of IL-6, vIL-6, and this has been hypothesized to be central to KSHV-MCD pathogenesis. However, viral and human cytokines have not been examined together in KSHV-MCD, and their contribution to disease activity and symptoms is not known. Methods: Patients with pathologically-proven KSHV-MCD were enrolled on a prospective natural history study incorporating pilot evaluation of novel therapies (NCT00099073). Factors potentially important in pathogenesis were assayed at flare and complete clinical and laboratory remission: KSHV viral load (VL) in peripheral blood mononuclear cells, vIL-6, IL-1β, IL-5, human IL-6 (hIL-6), IL-8, IL-10, IL-12p70, IFN-γ and TNF-α. Paired analyses were performed for each patient comparing initial flare and remission. Associations between cytokines and individual disease manifestations were explored across all flares. Results: 21 patients had at least one flare for analysis (19 [90%] male; med age 44 [range 29–52]). 34 flares were observed (range 1–3 per patient) and followed to remission (20 patients) or death (1). All were HIV infected: CD4 med 252cells/μL (range 24–1319), HIV VL med <48 copies/mL (<48–64,100), 94% receiving antiretrovirals. Clinical symptoms included fever (present in 62%, med 38°C [range 36.1–40.5]); fatigue (91%, med CTC grade 2 [0–3]), gastrointestinal (GI) symptoms (68%, med grade 1 [0–3]) and respiratory symptoms (61%, med grade 1 [0–2]). Laboratory findings included anemia (97%, 9.9g/L [6.8–14.4]), thrombocytopenia (68%, 100×103cells/μL [6–567]), hypoalbuminemia (97%, 2.7g/L [1.2–3.9]) hyponatremia (68%, 133mEg/L [127–143]) and C-reactive protein (CRP) elevation (100%, 87.3g/L [6.3–339.5]). Factors elevated during initial flares were: KSHV VL (med 14,700/106 PBMCs [range 0–3,913,000] P <0.0001 compared with remission); vIL-6 (detected in 48%, <1560pg/mL [<1560-20,500] P= 0.0039); hIL-6 (15.9pg/mL [1.4-171.5] P= 0.0006); IL-10 (449pg/mL [2.8-85,900] P= 0.0007); TNF-α (29.0 pg/ml [7.9–90.8] P= 0.0083) and IL-1β (1.2 pg/ml [0.1–5.7] P= 0.0027). IL-5 was decreased compared with remission (0.6 [0.1–15.4] P= 0.016). Differences were most marked for vIL-6 (undetectable in all remissions), hIL-6 (med increase from remission 520%) and IL-10 (med increase from remission 5000%). KSHV VL was correlated with hIL-6 (R = 0.68, P= 0.001) and IL-10 (R=0.82, P= 0.001) across all flares and remissions; other correlations were weaker. There was also a strong association between KSHV VL and vIL-6 (P= 0.001 by Jonckheere-Terpstra). For hIL-6 and vIL-6 only, we observed distinct profiles across flares: vIL-6 elevation only (2 flares, 6%), hIL-6 only (17 flares, 50%), and hIL-6 with vIL-6 (13 flares, 38%). In 2 flares (6%), neither vIL-6 nor hIL-6 were detected at onset, but in both hIL-6 alone soon became elevated. In contrast, KSHV VL, IL-10, TNF-α and IL-1β were consistently elevated during flares. Compared with hIL-6-only flares, hIL-6 with vIL-6 flares exhibited significantly higher CRP (P =0.0009); worse hyponatremia (P =0.02); higher KSHV VL (P =0.016) and IL-10 (P= 0.012); and lower IL-5 (P= 0.009). In linear/logistic regression models of disease manifestations with cytokines, best predictors were: GI symptoms, respiratory symptoms, temperature, platelet count: hIL-6 alone; hemoglobin: hIL-6 and vIL-6; sodium: hIL-6, vIL-6 and IL-10; albumin: IL-1β and vIL-6. Conclusions: This prospective analysis shows for the first time that vIL-6 and hIL-6 can independently or together lead to flares of KSHV-MCD. It shows novel associations of KSHV-MCD flares with IL-1β and TNF-α elevation and IL-5 depression while confirming associations with KSHV VL and IL-10. It further suggests that vIL-6 and hIL-6 may jointly contribute to the severity of some symptoms during flares. As vIL-6 can signal independently of the ligand-binding IL-6 receptor-a, these findings have implications for the development of novel KSHV-MCD therapies targeting IL-6 and its downstream signaling. Disclosures: No relevant conflicts of interest to declare.

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