Bibliographies thématiques / Mdz0

Littérature scientifique sur le sujet « Mdz0 »

Auteur : Grafiati
Publié le 25 juillet 2024

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Articles de revues sur le sujet "Mdz0"

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Fuentes, Yihajara, Claudia Giovagnoli-Vicuña, Mario Faúndez et Ady Giordano. « Microencapsulation of Chilean Papaya Waste Extract and Its Impact on Physicochemical and Bioactive Properties ». Antioxidants 12, no 10 (23 octobre 2023) : 1900. http://dx.doi.org/10.3390/antiox12101900.

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The microencapsulation of bioactive extracts of Chilean papaya waste, including both seeds and skin, was investigated. Papaya waste extract microcapsules utilizing maltodextrin at 10% (MD10), 20% (MD20), and 30% (MD30) (w/v) as the wall material through the freeze-drying process were obtained, and subsequently their physicochemical, antioxidant, and antimicrobial properties were evaluated. The TPC efficiency and yield values achieved were more than 60% for the microencapsulated seed and skin extracts, respectively. The best results for phenolic and antioxidant compounds were found in the microencapsulated seed extract with MD20, with a value of 44.20 ± 3.32 EAG/g DW for total phenols and an antioxidant capacity of 12.0 ± 0.32 mol ET/g DW for the DPPH and 236.3 ± 4.1 mol ET/g DW for the FRAP assay. In addition, the seed and skin samples reduced ROS generation in H2O2-treated Hek293 cells. In terms of antimicrobial activity, values ranging from 7 to 15 mm of inhibitory halos were found, with the maximum value corresponding to the inhibition of S. aureus, for both microencapsulated extracts. Therefore, the successful microencapsulation of the waste bioactive extracts (seed and skin) with the demonstrated antimicrobial and antioxidant properties highlight the bioactivity from Chilean papaya waste resources.
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Campo Fernández, Mercedes, Donna Fiorella Granja Rizzo, Nubia Lisbeth Matute Castro, Osmany Cuesta Rubio et Ingrid Márquez Hernández. « Microencapsulación mediante secado por atomización a partir de un extracto de los cálices de Hibiscus sabdariffa L. » Revista Colombiana de Química 50, no 1 (25 mars 2021) : 40–50. http://dx.doi.org/10.15446/rev.colomb.quim.v50n1.88424.

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La investigación tuvo como objetivo definir las mejores condiciones de extracción asistida por ultrasonido de los cálices de H. sabdariffa L. y la obtención de polvos microencapsulados, mediante secado por aspersión. Los extractos fueron analizados, considerando como variables: disolvente (agua y agua/etanol) y la relación temperatura/tiempo de extracción (25 ºC/60 min y 60 ºC/30 min). Para el secado se evaluaron las variables temperatura de entrada (150 ºC; 190 ºC) y la mezcla de encapsulantes goma arábiga (G) y maltodextrina (MD) (G40/MD60; G60/MD40). Los parámetros utilizados para el análisis fueron: rendimiento, pH, °Bx, composición química (fenoles y antocianinas totales, CLAE-EM) y capacidad antioxidante (DPPH). La mejor condición para la extracción de polifenoles resultó ser con agua:etanol (80:20), a 60 °C y durante 30 min. Se identificó la presencia de ácidos fenólicos, glicósidos de flavonoles y las antocianinas (delfinidina-3-sambubiósido y cianidina-3-sambubiósido), como las señales de mayor intensidad. Con el secado por atomización a 150 °C y con G60/MD40, se logró el mayor contenido de fenoles totales y antocianinas, sin embargo, la capacidad antioxidante se favoreció a 150 °C y con G40/MD60. Las micropartículas obtenidas podrían valorarse como materia prima para la elaboración de fitofármacos o alimentos funcionales, considerando su fácil manipulación, posible estabilidad y su valor antioxidante.
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Hejgaard, Jørn, William A. Laing, Salla Marttila, Andrew P. Gleave et Thomas H. Roberts. « Serpins in fruit and vegetative tissues of apple (Malus domestica) : expression of four serpins with distinct reactive centres and characterisation of a major inhibitory seed form, MdZ1b ». Functional Plant Biology 32, no 6 (2005) : 517. http://dx.doi.org/10.1071/fp04220.

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Most serpins irreversibly inhibit serine proteinases of the chymotrypsin family using a suicide-substrate-based mechanism. Serpins are present in all domains of life, but physiological functions in the plant kingdom are yet to be elucidated. Inhibitory properties of many abundant cereal grain serpins are well characterised, but serpins have not been identified in eudicot seeds. In apple (Malus domestica Borkh.), the origin of 88 serpin expressed sequence tags (ESTs) identified among 160 000 ESTs from 30 cultivar-, tissue- and time-specific libraries showed that serpin genes are expressed in a wide variety of tissues, including developing and mature fruits, seeds and vegetative buds as well as developing, mature and senescing leaves. Analysis of 46 sequences, most full-length, identified serpins with four distinct reactive centres belonging to two subfamilies (MdZ1 and MdZ2) with ~85% amino acid sequence identity. MdZ1 included three molecular forms with identical reactive centre loop (RCL) sequences except for three different, but related, residues at P2 (Asp, Asn or Glu). A major seed serpin, MdZ1b, with P2–P1′ Glu–Arg–Arg was purified from decorticated seeds and characterised kinetically. MdZ1b was a fast inhibitor of bovine and porcine trypsin (second-order association rate constant k a ~4 × 106 m –1 s–1 and stoichiometry of inhibition SI = 1). Human plasmin and urokinase-type plasminogen activator (u-PA), but not thrombin, were inhibited at lower rates (k a ~104 m –1 s–1). Chymotrypsin was inhibited at the same site (k a~4 × 103 m –1 s–1), but a significant part of MdZ1b was cleaved as substrate (SI > 2). Unexpectedly, the MdZ1b-trypsin complex was relatively short-lived with a first-order dissociation rate constant k d in the order of 10−4 s–1. The bulk of mature seed MdZ1b was localised to the cotyledons. The content of MdZ1b in ripe apples was 5–26 µg per seed, whereas MdZ1b could not be detected in the cortex or skin. Localisation and inhibitory specificity of serpins in monocot and eudicot plants are compared and putative functions are discussed.
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Lacey, D. L., J. C. Chappel et S. L. Teitelbaum. « Interleukin 1 stimulates proliferation of a nontransformed T lymphocyte line in the absence of a co-mitogen. » Journal of Immunology 139, no 8 (15 octobre 1987) : 2649–55. http://dx.doi.org/10.4049/jimmunol.139.8.2649.

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Abstract Although interleukin (IL) 2-responsive T cell lines provide an opportunity to study the cellular effects of this lymphokine on homogeneous T lymphocyte populations, T cell clones which proliferate in response to IL-1 alone have not been available. We have isolated from cultures of the nontransformed murine T helper cell line, D10 . G4 . 1, a variant (MD10 cells) which proliferates (no lectin or antigen needed) in response to IL-1 alone. The MD10 cells are markedly sensitive to either murine or human recombinant IL-alpha (HrIL-1 alpha) with half-maximal responses observed at monokine concentrations as low as 0.4 X 10(-12) M or 0.8 U/ml, respectively. MD10 cells show the maximal IL-1 effect at 72 hr where the response exceeds the base line by 100-fold (approximately 3,000----300,000 cpm of [3H]thymidine). Whereas both HrIL-2 and purified murine B cell-stimulatory factor 1 (MpBSF-1) induce MD10 proliferation, the maximal response to either is much lower (HrIL-2: 50X baseline; MpBSF-1: less than 20X base line) than to IL-1. Conditioned media from control, concanavalin A-, or IL-1-treated MD10 cells fail to stimulate CTLL or HT-2 cell proliferation alone or inhibit CTLL mitogenesis in the presence of added HrIL-2. Furthermore, monoclonal antibodies to BSF-1 fail to inhibit IL-1-stimulated MD10 replication, and neither HT-2 nor CTLL cells proliferate despite direct cell-to-cell contact with IL-1-treated MD10 cells. When combined, IL-1 (10(-13), 10(-12) M) and IL-2 (10(-13) to 10(-10) M) act synergistically in their MD10 cell growth-promoting effects. MD10 proliferation induced by either IL-1 or IL-2 is relatively resistant to cyclosporine A, with the ID50 of cyclosporine for both IL-1- and IL-2-exposed MD10 cells (ID50 5000 ng/ml) exceeding that for concanavalin A-activated splenocytes (ID50 20 ng/ml) by 2 to 3 orders of magnitude. Finally, MD10 cells bear the L3T4 antigen, IL-2 receptors, and the same clonotypic antigen receptor as the parent clone as recognized by monoclonal antibody 3D3. These data suggest that, in respect to this particular T cell line, IL-1 is directly growth-promoting or, alternatively, induces the production of undetectable, intermediate growth factor(s) resistant to inhibition by cyclosporine A.
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Civitelli, R., S. L. Teitelbaum, K. A. Hruska et D. L. Lacey. « IL-1 activates the Na+/H+ antiport in a murine T cell. » Journal of Immunology 143, no 12 (15 décembre 1989) : 4000–4008. http://dx.doi.org/10.4049/jimmunol.143.12.4000.

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Abstract One of the early events following growth factor exposure is elevation of intracellular pH, a process mediated by the Na+/H+ antiport. We studied the effects of human rIL-1 alpha (HrIL-1 alpha) on intracellular pH (pHi) and calcium ([Ca2+]i) in a murine T cell line (MD10 cells), which proliferates in response to IL-1 alone. By using the intracellularly trapped fluorescent dyes (2(1),7(1)-bis-2-carboxyethyl)-5(and -6) carboxyfluorescein) and indo-1, we monitored immediate to early changes of pHi and [Ca2+]i in response to HrIL-1 alpha. Exposure to HrIL-1 alpha (120 pM) leads to an early, sustained intracellular alkalinization (delta pH = + 0.09 +/- 0.03) that plateaus within 20 min. Lower concentrations of the monokine (12 pM, 1.2 pM) have a positive but not statistically significant effect on pHi. These effects parallel the degree of MD10 IL-1R saturation predicted by the KD (49 pM) as assessed by 125I-HrIL-1 alpha binding by MD10 cells (Bmax = approximately 1300). Both the MD10 IL-1 receptor KD and the HrIL-1 alpha concentration required to induce early measurable alkaline pH shifts, however, exceed by three orders of magnitude the HrIL-1 alpha ED50 (50 fM) required for MD10 proliferation. The IL-1-induced rise in pHi is both sodium dependent and amiloride sensitive, indicative of activation of the Na+/H+ antiport. Additionally, PMA (100 nM) and IL-2 (2 nM) alkalinize MD10 cells, with the rise in pHi as a result of PMA exceeding the maximal IL-1 effect (delta pH = + 0.13 +/- 0.04). Furthermore, although PMA alkalinizes cells previously exposed to HrIL-1 alpha, the monokine does not alter the pHi of PMA-treated MD10 cells. Importantly, intracellular alkalinization induced by either HrIL-1 alpha or PMA is inhibited by staurosporine (1 mu iM). Finally, HrIL-1 alpha does not change MD10 [Ca2+]i, in either an acute or sustained fashion. These results indicate that IL-1 activates the Na+/H+ antiport in T cells by a mechanism that is unrelated to changes in [Ca2+]i but may involve protein kinase C activation.
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Vernillo, Anthony. « Using Patients as Participants in Dental Board Exams for Licensure — A Contemporary Demonstration of Reductio ad Absurdum ». Journal of the Academy of Distinguished Educators 6, no 1 (2018) : 10. http://dx.doi.org/10.33682/56xr-mdz4.

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In his commentary, Dr. Vernillo supports Dr. Schloss's argument and goes further. He asserts that given advances in current computer and informational technology, board examinations that adequately assess dental students' clinical skills without the use of human subjects are doable, ethically justified, and should be mandated.
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Foo, Ning-Ping, Yu-Fan Liu, Ping-Ching Wu, Chung-Hsi Hsing, Bu-Miin Huang et Edmund-Cheung So. « Midazolam’s Effects on Delayed-Rectifier K+ Current and Intermediate-Conductance Ca2+-Activated K+ Channel in Jurkat T-lymphocytes ». International Journal of Molecular Sciences 22, no 13 (4 juillet 2021) : 7198. http://dx.doi.org/10.3390/ijms22137198.

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Midazolam (MDZ) could affect lymphocyte immune functions. However, the influence of MDZ on cell’s K+ currents has never been investigated. Thus, in the present study, the effects of MDZ on Jurkat T lymphocytes were studied using the patch-clamp technique. Results showed that MDZ suppressed the amplitude of delayed-rectifier K+ current (IK(DR)) in concentration-, time-, and state-dependent manners. The IC50 for MDZ-mediated reduction of IK(DR) density was 5.87 μM. Increasing MDZ concentration raised the rate of current-density inactivation and its inhibitory action on IK(DR) density was estimated with a dissociation constant of 5.14 μM. In addition, the inactivation curve of IK(DR) associated with MDZ was shifted to a hyperpolarized potential with no change on the slope factor. MDZ-induced inhibition of IK(DR) was not reversed by flumazenil. In addition, the activity of intermediate-conductance Ca2+-activated K+ (IKCa) channels was suppressed by MDZ. Furthermore, inhibition by MDZ on both IK(DR) and IKCa-channel activity appeared to be independent from GABAA receptors and affected immune-regulating cytokine expression in LPS/PMA-treated human T lymphocytes. In conclusion, MDZ suppressed current density of IK(DR) in concentration-, time-, and state-dependent manners in Jurkat T-lymphocytes and affected immune-regulating cytokine expression in LPS/PMA-treated human T lymphocytes.
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Lu, Hsin-Ling, King-Chuen Wu, Char-Wen Chen, Hung-Kai Weng, Bu-Miin Huang, Ting-Yu Lin, Ming-Hsin Liu, Edmund-Cheung So, Ruey-Mo Lin et Yang-Kao Wang. « Anticancer Effects of Midazolam on Lung and Breast Cancers by Inhibiting Cell Proliferation and Epithelial-Mesenchymal Transition ». Life 11, no 12 (13 décembre 2021) : 1396. http://dx.doi.org/10.3390/life11121396.

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Despite improvements in cancer treatments resulting in higher survival rates, the proliferation and metastasis of tumors still raise new questions in cancer therapy. Therefore, new drugs and strategies are still needed. Midazolam (MDZ) is a common sedative drug acting through the γ-aminobutyric acid receptor in the central nervous system and also binds to the peripheral benzodiazepine receptor (PBR) in peripheral tissues. Previous studies have shown that MDZ inhibits cancer cell proliferation but increases cancer cell apoptosis through different mechanisms. In this study, we investigated the possible anticancer mechanisms of MDZ on different cancer cell types. MDZ inhibited transforming growth factor β (TGF-β)-induced cancer cell proliferation of both A549 and MCF-7 cells. MDZ also inhibited TGF-β-induced cell migration, invasion, epithelial-mesenchymal-transition, and Smad phosphorylation in both cancer cell lines. Inhibition of PBR by PK11195 rescued the MDZ-inhibited cell proliferation, suggesting that MDZ worked through PBR to inhibit TGF-β pathway. Furthermore, MDZ inhibited proliferation, migration, invasion and levels of mesenchymal proteins in MDA-MD-231 triple-negative breast cancer cells. Together, MDZ inhibits cancer cell proliferation both in epithelial and mesenchymal types and EMT, indicating an important role for MDZ as a candidate to treat lung and breast cancers.
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Harigaya, Hiroko, Risako Chiba-Ohkuma, Takeo Karakida, Ryuji Yamamoto, Keiko Fujii-Abe, Hiroshi Kawahara et Yasuo Yamakoshi. « Potential for Drug Repositioning of Midazolam as an Inhibitor of Inflammatory Bone Resorption ». International Journal of Molecular Sciences 25, no 14 (12 juillet 2024) : 7651. http://dx.doi.org/10.3390/ijms25147651.

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Drug repositioning is a method for exploring new effects of existing drugs, the safety and pharmacokinetics of which have been confirmed in humans. Here, we demonstrate the potential drug repositioning of midazolam (MDZ), which is used for intravenous sedation, as an inhibitor of inflammatory bone resorption. We cultured a mouse macrophage-like cell line with or without MDZ and evaluated its effects on the induction of differentiation of these cells into osteoclasts. For in vivo investigations, we administered lipopolysaccharide (LPS) together with MDZ (LPS+MDZ) to the parietal region of mice and evaluated the results based on the percentage of bone resorption and calvaria volume. Furthermore, we examined the effects of MDZ on the production of reactive oxygen species (ROS) in cells and on its signaling pathway. MDZ inhibited osteoclast differentiation and bone resorption activity. In animal studies, the LPS+MDZ group showed a decreasing trend associated with the rate of bone resorption. In addition, the bone matrix volume in the LPS+MDZ group was slightly higher than in the LPS only group. MDZ inhibited osteoclast differentiation by decreasing ROS production and thereby negatively regulating the p38 mitogen-activated protein kinase pathway. Thus, we propose that MDZ could potentially be used for treating inflammatory bone resorption, for example, in periodontal disease.
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Shrestha, Nikesh, Saba Khan, Yub Raj Neupane, Shweta Dang, Shadab Md, Usama A. Fahmy, Sabna Kotta, Nabil A. Alhakamy, Sanjula Baboota et Javed Ali. « Tailoring Midazolam-Loaded Chitosan Nanoparticulate Formulation for Enhanced Brain Delivery via Intranasal Route ». Polymers 12, no 11 (4 novembre 2020) : 2589. http://dx.doi.org/10.3390/polym12112589.

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In the present study, midazolam (MDZ)-loaded chitosan nanoparticle formulation was investigated for enhanced transport to the brain through the intranasal (IN) route. These days, IN MDZ is very much in demand for treating life-threatening seizure emergencies; therefore, its nanoparticle formulation was formulated in the present work because it could substantially improve its brain targeting via the IN route. MDZ-loaded chitosan nanoparticles (MDZ-CSNPs) were formulated and optimized by the ionic gelation method and then evaluated for particle size, particle size distribution (PDI), drug loading (DL), encapsulation efficiency (EE), and in vitro release as well as in vitro permeation. The concentration of MDZ in the brain after the intranasal administration of MDZ-CSNPs (Cmax 423.41 ± 10.23 ng/mL, tmax 2 h, and area under the curve from 0 to 480 min (AUC0-480) of 1920.87 ng.min/mL) was found to be comparatively higher to that achieved following intravenous (IV) administration of MDZ solution (Cmax 245.44 ± 12.83 ng/mL, tmax 1 h, and AUC0-480 1208.94 ng.min/mL) and IN administration of MDZ solution (Cmax 211.67 ± 12.82, tmax 2 h, and AUC0-480 1036.78 ng.min/mL). The brain–blood ratio of MDZ-CSNPs (IN) were significantly greater at all sampling time points when compared to that of MDZ solution (IV) and MDZ (IN), which indicate that direct nose-to-brain delivery by bypassing the blood–brain barrier demonstrates superiority in brain delivery. The drug-targeting efficiency (DTE%) as well as nose-to-brain direct transport percentage (DTP%) of MDZ-CSNPs (IN) was found to be comparatively higher than that for other formulations, suggesting better brain targeting potential. Thus, the obtained results demonstrated that IN MDZ-CSNP has come up as a promising approach, which exhibits tremendous potential to mark a new landscape for the treatment of status epilepticus.
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Thèses sur le sujet "Mdz0"

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Flygare, Patrik, et Hampus Gustafsson. « Framtagning av layout och produktions- och materialflöde till MD60-linan på Maxidoor AB : Development of layout and production and material flow for the MD60 line at Maxidoor AB ». Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84449.

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Maxidoor AB är i en expanderingsfas och flera nya projekt har påbörjats, där ett av projekten är att designa en ny produktionslina för en ny produkt. Produkten som utvecklats är en branddörr som följer en ny standard och kräver en annan tillverkningsprocess än den som finns på företaget idag. Projektet som redovisas i rapporten handlar om att designa en produktionslina där målet är att linan ska ha kapacitet att tillverka 20 dörrar/skift. Utmaningar för att nå målet är att ytan som linan ska anläggas på är begränsad och då det är en ny produkt/produktionslina som utvecklats har inget nuläge funnits att utgå ifrån. Som hjälp för att ta fram en ny produktionslina har Bengt Andreassons steg för steg lista använts, där flera förslag på layouter genererats samt viktats utifrån att minska lean slöserier. Relevant teori såsom lean och produktionsteknik har samlats in och applicerats på det bästa förslaget för att skapa en effektiv process som har potential att nå målet. För att få fram vilka arbetsmoment och dess kapacitet produktionslinan behöver har intervjuer och en analys av ett tidigare examensarbete genomförts. Resultatet av projektet är en layout som minimerar lean slöserier där produktions- och materialflödet har definierats. Till arbetsmomenten har en metodstandard utvecklats med en kompletterande arbetsbeskrivning för att försöka säkerställa att kvalitet byggs in i processen. Material kommer beställas på order och genom ett kanbansystem.
Maxidoor AB is in an expansion phase and several new projects have been started, one of which is to design a new production line for a new product. The product that has been developed is a fire door that follows a new standard and requires a different manufacturing process than the one that the company has today. The project presented in the report is about designing a production line where the goal is for the line to have the capacity to manufacture 20 doors / shifts. Challenges to reach the goal are that the area on which the production line is to be built on is limited and since it is a new product / production line that has been developed, no current situation has been found to be based on. To help develop a new production line, Bengt Andreasson's step by step list has been used, where several suggestions for layouts have been generated and weighted based on reducing lean waste. Relevant theory such as lean and production technology has been collected and applied to the best proposal to create an efficient process that has the potential to reach the goal. In order to find out what work steps and their capacity the production line needs, interviews and an analysis of a previous degree project have been carried out. The result of the project is a layout that minimizes lean wastes where the production and material flow has been defined. For the work steps, a method standard has been developed with a supplementary job description to try to ensure that quality is built into the process. Materials will be ordered on order and through a kanban system.
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Virlogeux, Pascal. « Geologie de la marge nord-mozambique et de la chaine davie (9s a 21s) : campagne md40-macamo ». Paris 6, 1987. http://www.theses.fr/1987PA066662.

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Papo, Jones Malesela. « The effect of alloy chemistry and strain rate on the Md30 temperature of metastable austenitic stainless steels ». Master's thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/14045.

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Includes bibliographical references.
The work covered in this thesis provides a comprehensive discussion of the transformation behaviour of Type 304 metastable stainless steels with small' variations in alloy composition. The study focuses mainly on the austenite stability with respect to alloy composition, rate of deformation and temperature. To achieve these objectives, uniaxial tensile tests at 0.3 true strain were performed at low and high strain rates (10-3s-1 and 3 x 10-2s-1 respectively), in the temperature range of -60 to 55°C under isothermal testing conditions.
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Virlogeux, Pascal. « Géologie de la marge Nord-Mozambique et de la chaîne Davie campagne MD40-Macamo (9 °S à 21 °S) / ». Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37610659w.

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Li, Mengyao. « USING SEMIPHYSIOLOGICALLY-BASED PHARMACOKINETIC (SEMI-PBPK) MODELING TO EXPLORE THE IMPACT OF DIFFERENCES BETWEEN THE INTRAVENOUS (IV) AND ORAL (PO) ROUTE OF ADMINISTRATION ON THE MAGNITUDE AND TIME COURSE OF CYP3A-MEDIATED METABOLIC DRUG-DRUG INTERACTIONS (DDI) USING MIDAZOLAM (MDZ) AS PROTOTYPICAL SUBSTRATE AND FLUCONAZOLE (FLZ) AND ERYTHROMYCIN (ERY) AS PROTOTYPICAL INHIBITORS ». VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4402.

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The purpose of the project was to investigate the impact of IV and PO routes difference for MDZ, a prototypical CYP3A substrate, and two CYP3A inhibitors (CYP3AI) -FLZ and ERY-, on the magnitude and time course of their inhibitory metabolic DDI. Individual semi-PBPK models for MDZ, FLZ and ERY were developed and validated separately, using pharmacokinetic (PK) parameters from clinical/in-vitro studies and published physiological parameters. Subsequently, DDI sub-models between MDZ and CYP3AIs incorporated non-competitive and mechanism-based inhibition (MBI) for FLZ and ERY, respectively, on hepatic and gut wall (GW) CYP3A metabolism of MDZ, using available in-vitro/in-vivo information. Model-simulated MDZ PK profiles were compared with observed data from available clinical PK and DDI studies, by visual predictive check and exposure metrics comparison. DDI magnitude and time course for CYP3AI (IV vs. PO) followed by MDZ (IV vs. PO) at various time points were predicted by the validated semi-PBPK-DDI models. Two hypothetical CYP3A substrates and four CYP3AI (derived from MDZ, FLZ and ERY, with GW metabolism removed, hepatic metabolism reduced, or oral bioavailability (Foral) and/or elimination half-life (t1/2) modified) were also simulated to generalize conclusions. The final semi-PBPK-DDI models predict well the PK profiles for IV/PO MDZ in absence/presence of IV/PO CYP3AI, with deviations between model-predicted and observed exposure metrics within 30%. Prospective simulations demonstrate that: 1) CYP3A substrates, e.g., MDZ, are consistently more sensitive to metabolic inhibition after PO than after IV administration, due to pre-systemic hepatic and/or GW metabolism. For substrates without GW metabolism and limited hepatic metabolism, only a marginal route difference for substrate administration is observed. 2) For high-Foral CYP3AIs, e.g., FLZ, no inhibitor IV-PO route DDI differences are expected, unless they are given simultaneously with PO MDZ. 3) For low-Foral CYP3AIs, e.g., ERY, greater inhibition is expected after IV than after PO administration for IV MDZ, but is difficult to predict for PO MDZ. 4) In addition to Foral and plasma t1/2 of CYP3AIs, the DDI onset, peak and duration are determined by their oral absorption rate and by the resulting hepatic and/or GW concentration profiles relative to Ki for noncompetitive CYP3AIs, but by CYP3A kinetics (synthesis, degradation rate) for MBI CYP3AIs.
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Vaňková, Barbora. « Testové proměnné v Blochově Vícedimenzionálním kresebném testu (Mehrdimensionale Zeichentest - MDZT) u epileptiků ». Master's thesis, 1993. http://www.nusl.cz/ntk/nusl-365927.

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Izawa, Chika. « Extended TOF-SIMS analysis on low-nickel austenitic stainless steels : The influence of oxide layers on hydrogen embrittlement ». Doctoral thesis, 2015. http://hdl.handle.net/11858/00-1735-0000-0028-8693-0.

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Livres sur le sujet "Mdz0"

1

19uu. bod ljongs mdza' gzhas. Pe cin : Mi rigs dpe skrun khang, 2005.

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Tchiba, Martin. MD60 : Worte-Klänge-Bilder zum 60. Geburtstag des Komponisten Michael Denhoff. Brühl : Edition Gravis, 2015.

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Siregetu̇ Gu̇u̇si Corji, fl. 1587-1618., Bu̇rnėė D et Ėnkhtȯr D, dir. Mdza ṅs blun źes bya baʾi mdo = : U̇lgėriĭn dalaĭ : Shuluun unalt khėmėėkh sudar. Ulaanbaatar : [s.n.], 1996.

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Ludwig, Werner, Dr. rer. nat., Friedrich-Schiller-Universität Jena. Sektion Chemie. MDZ "Thermische Analysenverfahren." et Chemische Gesellschaft der Deutschen Demokratischen Republik. AG Thermoanalyse., dir. Thermische Analysenverfahren in Industrie und Forschung : Arbeitstagung der Sektion Chemie der Friedrich-Schiller-Universität Jena MDZ "Thermische Analysenverfahren" und der AG Thermoanalyse der Chemischen Gesellschaft der DDR, 6. bis 8. September 1989 in Jena. Jena : Friedrich-Schiller-Universität, 1990.

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Nagaura, Ky¿. Mdzu : Murders. Kodansha, Limited, 2019.

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泽绒降措. Rta'i yi mdza' gzhas. 2019.

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Critical Care Manual of Clinical Procedures and Competencies. Wiley & Sons, Limited, John, 2013.

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Occupational Health Law. Wiley & Sons, Limited, John, 2008.

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Occupational Health Law. Wiley & Sons, Limited, John, 2010.

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Chapitres de livres sur le sujet "Mdz0"

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« Midazolam (MDZ) ». Dans Checkliste Arzneimittel A–Z, sous la direction de Detlev Schneider et Frank Richling. Stuttgart : Georg Thieme Verlag, 2013. http://dx.doi.org/10.1055/b-0034-82589.

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Steenbarger, Brett. « Solution-Focused Brief Therapy ». Dans The Art and Science of Brief Psychotherapies. American Psychiatric Association Publishing, 2017. http://dx.doi.org/10.1176/appi.books.9781615372072.md10.

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Plioplys, Sigita, et Miya Asato. « Neurological Examination, Electroencephalography, and Neuroimaging ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing, 2009. http://dx.doi.org/10.1176/appi.books.9781585623921.md10.

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Connolly, Sucheta, et Liza Suárez. « Generalized Anxiety Disorder, Specific Phobia, Panic Disorder, Social Phobia, and Selective Mutism ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing, 2009. http://dx.doi.org/10.1176/appi.books.9781585623921.md20.

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Hamilton, John, et Eric Daleiden. « Evidence-Based Practices ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing, 2009. http://dx.doi.org/10.1176/appi.books.9781585623921.md30.

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Walsh, Froma. « Family Transitions ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing, 2009. http://dx.doi.org/10.1176/appi.books.9781585623921.md40.

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Scahill, Lawrence, Yann Poncin et Alexander Westphal. « Alpha-Adrenergics, Beta-Blockers, Benzodiazepines, Buspirone, and Desmopressin ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing, 2009. http://dx.doi.org/10.1176/appi.books.9781585623921.md50.

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Nagy, Paul. « Motivational Interviewing ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Publishing, 2009. http://dx.doi.org/10.1176/appi.books.9781585623921.md60.

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Pliszka, Steven. « Attention-Deficit/Hyperactivity Disorder ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Association Publishing, 2015. http://dx.doi.org/10.1176/appi.books.9781615370306.md10.

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Eddy, Kamryn, Helen Murray et Daniel Le Grange. « Eating and Feeding Disorders ». Dans Dulcan’s Textbook of Child and Adolescent Psychiatry. American Psychiatric Association Publishing, 2015. http://dx.doi.org/10.1176/appi.books.9781615370306.md20.

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Actes de conférences sur le sujet "Mdz0"

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NICHOLS, HERBERT. « UDF engine/MD80 flight test program ». Dans 24th Joint Propulsion Conference. Reston, Virigina : American Institute of Aeronautics and Astronautics, 1988. http://dx.doi.org/10.2514/6.1988-2805.

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Zhao, Kai, Sheng Di, Danny Perez, Xin Liang, Zizhong Chen et Franck Cappello. « MDZ : An Efficient Error-bounded Lossy Compressor for Molecular Dynamics ». Dans 2022 IEEE 38th International Conference on Data Engineering (ICDE). IEEE, 2022. http://dx.doi.org/10.1109/icde53745.2022.00007.

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Azevedo, Ruan de, Adriel Barbosa, Gabriel de Souza, João Férrer, Márcio Lima, Pedro Fraiman, Rafael Maffei et al. « Super refractory status epilepticus in a child : brain on “fires” ». Dans XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.700.

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Introduction: New onset of a refractory status epilepticus (NORSE) is a clinical presentation, without a clear cause, within the first 72h of admission of a non-epileptic patient. FIRES (Febrile Infection-Related Epilepsy Syndrome) is a NORSE subgroup with febrile prodrome 24 hours to 2 weeks before the onset of status. This case reports a previously healthy 7-year-old female with FIRES and super refractory status epilepticus (SE). Methods: This is a case report based on retrospective analysis of a single patient’s medical record. Results: The patient presented with SE four days after low grade fever and airway infection. Midazolam (MDZ) 0.15 mg/kg, phenytoin (PFT) 30 mg/ kg, phenobarbital (PB) 15 mg/kg were administered in sequence; followed by continuous infusion of MDZ 1 mg/kg/h and ketamine (KET) 30 mcg/kg/ min. Empirical treatment started with ceftriaxone, acyclovir and ampicillin. Exams on admission: Brain magnetic resonance (MRI) with no abnormalities; normal serum leukocyte count and electrolyte levels; cerebrospinal fluid (CSF) with 61 cells (71% lymphocytes), protein 38, Lactate 15, glucose 61 (mg/dL). CSF on two different occasions was negative for infectious agents and autoimmune antibodies. Electroencephalograms (EEG) on the 3rd, 4th and 7th days after hospitalization revealed SE despite the followings drugs: Levetiracetam 60 mg/kg, Lacosamide 10 mg/kg, topiramate 10 mg/kg, MDZ 2 mg/kg/h, KET 2 mg/kg/h. Throughout hospitalization, she received a 3 days course of methylprednisolone 30 mg/kg/day, followed by five days of immunoglobulin 2 g/ kg/day, ketogenic diet and thiopental 5 mg/kg/h. From the 13th day on, EEG maintained global suppression and no epileptiform activity. The patient died on the 18th day after a septic shock. Conclusion: NORSE and FIRES are entities with unfavorable outcomes and high mortality rates. Autoimmune/inflammatory encephalitis represents 40% of NORSE causes.
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Nagashima, Yasuaki, Shinichi Onuki, Yoshiharu Shimose, Atsushi Yamada et Tomoyuki Kikugawa. « Asymmetric-Cladding 1480-nm Pump Laser with CW Fiber Output Power of 1 W ». Dans Optical Amplifiers and Their Applications. Washington, D.C. : OSA, 2003. http://dx.doi.org/10.1364/oaa.2003.md10.

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Lin, Ching-Fuh, Chia-Wei Tsai, Yi-Shin Su et Gagik Sh Shmavonyan. « Extremely Broadband InGaAsP/InP Superluminescent Diode/Semiconductor Optical Amplifiers with Emission Spectrum Covering from 1250 nm to 1650 nm ». Dans Optical Amplifiers and Their Applications. Washington, D.C. : OSA, 2003. http://dx.doi.org/10.1364/oaa.2003.md20.

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Hu, Hua, Longfa Pan et Yi Ni. « A New Rate 8/12 Run-Length Limited (2, 9) Code for Four-Level Read-Only Optical Disc ». Dans Optical Data Storage. Washington, D.C. : OSA, 2007. http://dx.doi.org/10.1364/ods.2007.md10.

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Dubinin, Alexander, Tatyana Cherezova, Alexey Belyakov et Alexis Kudryashov. « Human Retina Imaging : Anisoplanatism Considerations ». Dans European Conference on Biomedical Optics. Washington, D.C. : OSA, 2005. http://dx.doi.org/10.1364/ecbo.2005.md10.

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Folks, William R., Sidhartha K. Pandey et Glenn Boreman. « Refractive Index at THz Frequencies of Various Plastics ». Dans Optical Terahertz Science and Technology. Washington, D.C. : OSA, 2007. http://dx.doi.org/10.1364/otst.2007.md10.

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Yao, Xin-Cheng, et John S. George. « Fast Optical Imaging of Neural Activation in Isolated Retina ». Dans Biomedical Topical Meeting. Washington, D.C. : OSA, 2006. http://dx.doi.org/10.1364/bio.2006.md10.

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Vernhes, Richard, Oleg Zabeida, Jolanta Klemberg-Sapieha et Ludvik Martinu. « Properties, Growth and Filter Applications of a-SiN^x:H Alloys Prepared in Pulsed Radiofrequency Plasma ». Dans Optical Interference Coatings. Washington, D.C. : OSA, 2007. http://dx.doi.org/10.1364/oic.2007.md10.

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Rapports d'organisations sur le sujet "Mdz0"

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Fischl, Iris, Joachim Kaufmann et Thomas Oberholzner. Zwischenevaluierung des FTI-Programms "Mobilität der Zukunft" (MdZ). Bmvit, août 2018. http://dx.doi.org/10.22163/fteval.2018.346.

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Tiefenthaler, Brigitte, et Simon Zingerle. Externe Wirkungsprüfung der Urbanen Mobilitätslabore. Https://mobilitaetderzukunft.at, novembre 2020. http://dx.doi.org/10.22163/fteval.2020.503.

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In der vorliegenden externen Wirkungsprüfung wurden jene fünf Urbanen Mobilitätslabore (UML), die in der 7. Ausschreibung des Forschungsförderungsprogramms "Mobilität der Zukunft (MdZ)" gefördert wurden, auf die bisher erzielten Ergebnisse und Wirkungen untersucht. Einerseits auf der Ebene des einzelnen UML und andererseits auf der Ebene der UML-Initiative insgesamt. Ziel war es, das bisher Erreichte und die damit verbundenen Erfahrungen zu analysieren und auf dieser Grundlage Empfehlungen für die künftige Arbeit in diesem Rahmen (und möglicherweise darüber hinaus) zu entwickeln.
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