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1
OLOBATUYI, KEHINDE IBUKUN. "A Family of Variational Algorithms for Approximate Bayesian Inference of High-Dimensional Data." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/325856.
Texte intégralRésumé :
L’approccio Bayesiano alle tecniche di machine-learning consente di integrare in un modello le informazioni a priori per evitare problemi di overfitting, cercando di approssimare la distribuzione a posteriori. Fornisce inoltre una metodologia coerente per la scelta fra diversi modelli alternativi, e richiede tipicamente uno sforzo computazionale considerevole, tale da rendere alcuni problemi intrattabili.
Questa tesi propone una famiglia di metodologie di tipo Variational Bayes per approssimare la complessità computazionale dell’approccio Bayesiano tramite l’utilizzo di variabili latenti, minimizzando la distanza di Kullback-Leibler tra la distribuzione a posteriori esatta e quella approssimata. Il primo capitolo riepiloga i concetti chiave dell’inferenza bayesiana e gli algoritmi di propagazione. Il secondo capitolo introduce il metodo Variational Bayes, il quale generalizza gli algoritmi di Expectation Maximization (EM) per la stima dei parametri tramite un approccio a massima verosimiglianza. Vengono inoltre discusse le approssimazioni fattorizzate per i metodi di Expectation Propagation (EP). Nei capitoli da 3 a 5 vengono derivate e testate diverse varianti dei metodi Variational Bayes per la famiglia dei Cluster Weighted Models (CWMs) e, partendo da un breve cenno storico, vengono proposte diverse nuove classi di CWM. Inizialmente viene analizzato il problema della riduzione di dimensionalità nei CWM, introducendo una nuova classe basata su t-distributed stochastic neighbor embedding (tSNE). Nel secondo lavoro viene proposto un Multinomial CWM per la classificazione multinomiale ed un Zero-inflated Poisson CWM per dati di tipo zero-inflazionato. Vengono derivati ed applicati gli algoritmi EM per la stima dei parametri, considerando tre diverse alternative per il passo di massimizzazione: Minimi Quadrati Ordinari (OLS), Minimi Quadrati Pesati Iterati (IRLS), e Discesa Stocastica del Gradiente (SGD). Per concludere, vengono testate le performance classificative dei modelli CWM utilizzando otto criteri diversi e vari Adjusted Rand Index (ARI). Nel sesto capitolo vengono proposte due varianti del metodo di Expectation Propagation per inverse models denominate EP-MCMC e EP-ADMM, applicandole a modelli bayesiani per image-reconstruction e confrontandone le performance con i metodi MCMC. Il settimo capitolo chiude la tesi, traendo le conclusioni dei lavori svolti e riassumendo i possibili sviluppi futuri.<br>The Bayesian framework for machine learning allows the incorporation of prior knowledge into the system in a coherent manner which avoids overfitting problems but rather seeks to approximate the exact posterior and provides a principled basis for the selection of model among alternative models. Unfortunately, the computation required in Bayesian framework is usually intractable. This thesis provides a family of Variational Bayesian (VB) framework which approximates these intractable computations with latent variables by minimizing the Kullback-Leibler divergence between the exact posterior and the approximate distribution.
Chapter 1 presents background materials on Bayesian inference, and propagation algorithms. Chapter 2 discusses the family of variational Bayesian theory. It generalizes the expectation maximization (EM) algorithm for learning maximum likelihood parameters. Finally, it discusses factorized approximation of Expectation propagation.
Chapter 3 - 5 derive and apply the variants of Variational Bayesian to the family of cluster weighted models (CWMs). It investigates the background history of CWM and proposes new different members into the family. First, the dimensionality of CWM is explored by introducing the t-distributed stochastic neighbor embedding (tSNE) for dimensionality reduction which leads to CMWs based on tSNE for high-dimensional data. Afterwards, we propose a Multinomial CWM for multiclass classification and Zero-inflated Poisson CWM for zero-inflated data. This work derives and applies the Expectation Maximization algorithm with three different maximization step algorithms: Ordinary Least Squares (OLS), Iteratively Reweighted Least Squares (IRLS), and Stochastic Gradient Descent (SGD) to estimate the models' parameters. It finally examines the classification performance of the family of CWM by eight different information criteria and varieties of Adjusted Rand Index (ARI).
Chapter 6 proposes a variant of Expectation Propagation: EP-MCMC, EP-ADMM algorithms to the inverse models. It demonstrates EP-MCMC and EP-ADMM on complex Bayesian models for image reconstruction and compares the performance to MCMC. Chapter 7 concludes with a discussion and possible future directions for optimization algorithms.
2
Taouli, Abderrahim [Verfasser]. "Aciditäts- und Adsorptionsuntersuchungen an mesoporösen MCM-41- und MCM-48-Materialien / Abderrahim Taouli." Aachen : Shaker, 2003. http://d-nb.info/1172613982/34.
Texte intégral
3
Bandyopadhyay, Mahuya. "Synthesis of mesoporous MCM-48 with nanodispersed metal and metal oxide particles inside the pore system." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=974056669.
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4
Nalbant, Asli. "Synthesis And Characterization Of Cu-mcm-41 And Ni-mcm-41 Type Catalytic Materials." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/3/12605788/index.pdf.
Texte intégralRésumé :
Discovery of mesoporous materials by Mobil researchers in 1992 opened a new field in catalytic applications. The materials designated as M41S family are MCM-41 with one-dimensional hexagonal structure, MCM-48 with three-dimensional cubic structure and MCM-51 with unstable lamellar structure. This family of materials have high surface areas up to 1500 m2/g, narrow pore size distributions with pore sizes varying from 20 to 100 Å<br>. These materials can be activated by incorporation of metals or active compounds into their structures.
In this study, copper and nickel incorporated MCM-41 type catalytic materials were synthesized via different methods namely, impregnation, high temperature and low temperature direct synthesis methods. The Cu-MCM-41, and Ni-MCM-41, as well as synthesized MCM-41 were characterized by using XRD, TEM, N2 sorption, SEM, XRF, EDS, AAS and TPR.
MCM-41 was synthesized with high temperature direct synthesis method. High surface area values up to 1400 m2/g of MCM-41 mesoporous materials were obtained with high pore volumes up to 1.17 cc/g.
Cu-MCM-41 type catalytic materials were synthesized with three different methods. Impregnation and high temperature direct synthesis methods gave better results than those of low temperature direct synthesis method. In impregnation, relatively high surface area values (730 m2/g) were obtained with Cu/Si mole ratio as high as 0.3 in the product. For the case of high temperature direct synthesis products, Cu/Si mole ratios as high as 0.26 were obtained with somewhat smaller surface areas (400 m2/g). Low temperature direct synthesis method is the least favorable method in metal loading.
Ni-MCM-41 type of catalytic materials were synthesized by impregnation and high temperature direct syntheses methods. Ni incorporation by high temperature direct synthesis method gave high surface area values (560-930 m2/g) having Ni/Si mole ratios of 0.12-0.28.
5
FREIRE, Vitória de Andrade. "Desenvolvimento de material micro-mesoporoso do tipo MCM-22/MCM-41: sítese e caracterização." Universidade Federal de Campina Grande, 2016. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/297.
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Previous issue date: 2016-04-29<br>Capes<br>A pesquisa no desenvolvimento de estruturas do tipo micro-mesoporosas tem
por intuito a obtenção de materiais porosos com características superiores, uma
vez que busca unir a ácidez elevada da zeólita MCM-22, com o sistema de
mesoporos, da peneira molecular MCM-41, consequentemente melhorar a
difusão de moléculas volumosas. Nesta pesquisa foram sintetizadas as
seguintes estruturas porosas: Inicialmente foi obtido o percussor lamelar MCM22-(P)
com razão molar SiO2\Al2O3 = 30 e ativada para obter sua forma zeólítica
MCM-22 a 550 0C por 5 horas. Em seguida, foi realizada a síntese do material
micro-mesoporoso do tipo MCM-22/MCM-41, tratando 2 g da zeólita MCM-22,
com uma solução de 25 mL de brometo de cetiltrimetilamônio (CTABr) a 10 %
em massa, onde o material permaneceu em estufa a 1100C por 7 dias. Com o
intuito de obter um novo material com melhor organização estrutural, utilizou-se
a MCM-22 nas seguintes proporções (5%, 10% e 15%), permanecendo em
estufa a 300C por 24 horas, sendo ativado em corrente de ar por 5500C por 5
horas. Os resultados das caracterizações de difratometria de raios-X,
evidenciaram a formação do precursor MCM-22 (P) e sua forma zeólítica MCM22,
com os picos da topologia MWW. A curvas obtidas por meio da análise
termogravimétrica (TG/DrTG), demostraram as perdas de massa da água e
demais adsorvatos. As micrografias (MEV), apresentou formato toroidal com
depreciamento na região central para a MCM-22. Por meio dos resultados de
adsorção física de N2, verifica-se que as zeólitas MCM-22, com isotermas do tipo
I e loop de histerese do tipo H4. A partir dos difratogramas de raios - X para os
materiais micro-mesoporosos foi possível observar a formação das estruturas
porosas, com a identificação dos picos de reflexão pertinentes a fase
microporosa da MCM-22 e da peneira molecular MCM-41, coexistindo em uma
única fase estrutural. As imagens obtidas por MEV, detectam a formação de
aglomerados de partículas da fase mesoporosa sendo constituída em torno da
fase microporosa. A análise textural mostraram uma diminuição do volume de
microporos e um aumento do volume de mesoporos, com isotermas do tipo IV e
histereses 2. Demonstrando assim que as caracterizações foram eficazes na
elucidação das estruturas porosas. Foi possível obter os materiais micromesoporosos
para ambas as metodologias adotadas, sendo o teor de 5% de
zeólita MCM-22 a melhor condição de síntese para obtenção desse novo material.<br>The research on the development of micro-mesoporous structures has the
purpose of obtaining porous materials with superior characteristics, once it seeks
to join the high acidity of MCM-22 zeolite with the mesoporous system of MCM41
molecular sieve, consequently improving the diffusion of bulky molecules. In
this research, the following porous structures were synthesized: Initially, the
MCM-22-(P) lamellar precursor was obtained with molar ratio of SiO2\Al2O3 = 30
and was activated to obtain its MCM-22 zeolite form at 550 °C for 5 hours. Then,
MCM-22/MCM-41 micro-mesoporous material was synthesized by treating 2 g of
MCM-22 zeolite with a solution of 25 mL of 10% wt cetyltrimethylammonium
bromide (CTABr), where the material remained in an incubator at 110 °C for 7
days. In order to obtain a new material with better structural organization, the
MCM-22 was used in the following proportions (5%, 10% and 15%), remaining in
an incubator at 30 °C for 24 hours, being activated in air stream at 550 °C for 5
hours. The results of the X-ray diffraction characterization demonstrated the
MCM-22 (P) precursor formation and its MCM-22 zeolite form, with MWW
topology peaks. The curves obtained by means of the thermogravimetric analysis
(TG/DrTG), showed the losses of water mass and other adsorbates. The
micrographs (SEM) presented toroidal format with depreciation in the central
region for MCM-22. By means of the results of physical adsorption of N2, it was
verified for MCM-22 zeolites: type I isotherms and hysteresis loops of type-IV.
From the X-ray diffractograms for the micro-mesoporous materials, it was
possible to observe the formation of the porous structures, with the identification
of the reflection peaks pertinent to the microporous phase of MCM-22 and the
MCM-41 molecular sieve, coexisting in a single structural phase. The SEM
images detected the formation of particle agglomerates of the mesoporous phase
being constituted around the microporous phase. The textural analysis showed a
decrease in the volume of micropores and an increase in the volume of
mesopores, with type IV isotherms and hysteresis loops of type-II. Thus
demonstrating that the characterizations were effective in elucidating the porous
structures. It was possible to obtain the micro-mesoporous materials for both
methodologies, being the 5% content of MCM-22 zeolite the best synthesis
condition to obtain this new material.
6
Konak, Edith. "Identifikation von Signalweginteraktionspartnern des Zelladhäsionsmoleküls Muc18/MCAM/CD146." Diss., lmu, 2000. http://nbn-resolving.de/urn:nbn:de:bvb:19-2421.
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Dye, Danielle E. "The role of MCAM in melanoma and metastasis." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0207.
Texte intégralRésumé :
[Truncated abstract] Melanoma cell adhesion molecule (MCAM) is highly expressed in more than 70% of metastatic melanoma and is correlated with invasive potential. However, the specific contribution MCAM makes to invasion and metastasis in melanoma is not clear. In this study, I have demonstrated that transfection of MCAM into MCAM-negative melanoma and CHO cells leads to changes in cell shape, and the modulation of cell-to-cell and cell-matrix interactions. MCAM positive cells were slower to spread on collagen type I, collagen type IV and laminin 1 than MCAM negative cells, although these differences were not apparent on vitronectin, fibronectin and laminin 10. In contrast, MCAM expression had little effect on cell adhesion to any of the matrices tested. MCAM positive (compared to negative) cells also showed morphological changes and a rearrangement of the actin cytoskeleton when plated on a matrix containing laminin 5. Taken together, these data suggest that MCAM expression modulates β1-integrinmediated spreading on matrix, but has little effect on αvβ3-mediated cell-matrix interactions. As this study provided little evidence to suggest that MCAM transfection altered β1 integrin expression levels on melanoma cells, it is proposed that a competitive interaction between the cytoplasmic domains of MCAM and β1 integrin may affect mature focal adhesion assembly. MCAM expression in melanoma cells was also associated with decreased cell movement over matrix into a scratch-wound site and an increased tendency to form cell cords on Matrigel. These two assays gauge the propensity of a cell to engage in cell-cell versus cell-matrix interactions, and suggest that MCAM positive cells favour cell-cell adhesion. Interestingly, MCAM transfection was also associated with an increased ability of melanoma cells to migrate through a basement membrane towards a chemoattractant. ... Analysis of the intracellular domain of MCAM revealed the presence of tyrosine and dileucine endocytosis signals. Interestingly, disruption of these two motifs did not seem to impair the internalization of MCAM from the cell surface. The di-leucine motif, however, was necessary for the recycling of MCAM back to the surface following endocytosis. Lastly, MCAM was found to exists as dimers within the cell membrane in the absence of ligand, although the exact location of the dimerization motif is not yet clearly defined. Collectively, findings from my study suggest: MCAM expression in melanoma cells facilitates cell-cell interactions, whilst concomitantly modulating cell-matrix interactions. MCAM transfection also leads to enhanced migration of melanoma cells through a basement membrane. Thus, MCAM expression may increase the ability of melanoma cells to migrate as a collective, a feature of highly invasive cancer. The intracellular domain of MCAM interacts with ApxL2, a novel member of the Shroom family of actin-binding proteins. It is likely that ApxL2 links a proportion of MCAM within the cell to the actin cytoskeleton, contributing to cell shape determination and other processes, such as migration. MCAM exists as dimers on the cell surface and is internalized at least partially by a clathrin-mediated mechanism.
8
Kuismin, M. (Markku). "EM- ja MCEM-algoritmi apuvälineenä suurimman uskottavuuden estimoinnissa." Master's thesis, University of Oulu, 2013. http://urn.fi/URN:NBN:fi:oulu-201312051972.
Texte intégralRésumé :
Tutkielmassa tutkitaan suurimman uskottavuuden menetelmään perustuvaa Expected Maximization-algoritmia (EM-algoritmi). Työn pääpaino on algoritmin ominaisuuksien teoreettisessa tarkastelussa eikä siinä käsitellä todellisia tutkimusongelmia tai empiirisiä aineistoja.
Aluksi tarkastellaan algoritmia matemaattisesti SU-menetelmän tavoin. Tämä teoriaosuus perustuu pääsääntöisesti McLachlanin ja Krishnanin kirjaan The EM Algorithm and Extensions (1997). Algoritmin avulla tutkitaan kahden normaalijakauman sekoitusta ja tähän liittyviä parametreja. Tämä esimerkki perustuu pääsääntöisesti Louisin (1982) artikkeliin.
EM-algoritmin lisäksi tutkitaan Monte Carlo EM-algoritmia (MCEM-algoritmi). Algoritmia sovelletaan yksinkertaisen yleistetyn lineaarisen sekamallin parametrien analysoinnissa. Aineistona käytetään McCullochin artikkelin esimerkin mukaan simuloitua binääristä dataa. Tässä osuudessa lähteinä on pääsääntöisesti käytetty McCullochin artikkelia Maximum likelihood algorithms for generalized linear mixed models (1997) ja Robertin ja Casellan kirjaa Introducing Monte Carlo Methods with R (2010).
Lopuksi vertaillaan muodostetulla MCEM-algoritmilla laskettuja estimaatteja toiseen Markovin ketju Monte Carlo-menetelmään. Tätä varten simuloitua aineistoa analysoidaan myös bayesiläisittäin soveltamalla Gibbsin otantaa parametrien posteriorien simuloimisessa. Pääasiallisena lähteenä on käytety Läärän kirjoittamaa luentomonistetta Johdatus bayesiläiseen tilastotieteeseen (2013).
EM-algoritmilla saatiin normaalijakaumien sekoituksessa erittäin hyviä SU-estimaatteja. Algoritmi on herkkä alkuarvojen valinnalle ja kaukana SU-estimaateista valituilla alkuarvoilla algoritmia on ajettava kauan uskottavuuden maksimoimiseksi. MCEM-algoritmin tapauksessa Monte Carlo otoskoon valitseminen liian suureksi lähinnä hidastaa algoritmia kohtuuttomasti eikä millään tavalla edistä algoritmin stabiloitumista. Tutkielmassa ei saatu MCEM-algoritmilla estimaatteja, jotka olisivat maksimoineet uskottavuusfunktion arvon. Laskemalla aineistosta bootsrap-estimaatit saatiin paremmat tulokset, joilla uskottavuusfunktion arvo on MCEM-estimaatteja suurempi.
9
Satti, Rabab. "Modulation of MCM Helicase activity." Thesis, University of York, 2011. http://etheses.whiterose.ac.uk/2418/.
Texte intégralRésumé :
The minichromosome maintenance (MCM) proteins are essential for the initiation and progression of DNA replication. MCMs are believed to function as the replicative helicase in archaea and eukaryotes. In the present studies, human MCM and archaeal MCM from Methanococcus maripaludis were purified from E.coli and assembled as complexes. The six MCMs from human eo-purified over multiples steps including three chromatographic steps when eo-expressed in E. coli suggesting that they form a heterohexamer complex. Reconstitution of in vitro helicase activity of the human complex and individual subunits of M maripaludis were described. Furthermore the effect of phosphorylation on human MCM complex and M maripaludis MCM A were also tested and the effect of phosphorylation was shown to be inhibitory on helicase activities. Different reaction conditions were monitored on MCM helicase activity and the most interesting was the effect of salts on helicase assays which showed that glutamate has a significant positive effect while chloride ions inhibit helicase activity. Putative kinases were purified from M maripaludis and Methanocaldococcus jannaschii and trials were conducted to assign them a role in regulating the DNA initiation process.
10
Maile, Eva C. "Beiträge zur precursorchemischen Präparation von Cu/ZnO- und Pd/ZnO- Trägerkatalysatoren." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975798758.
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Musengi, Sandra. "The role of bank finance in small firm growth : a case study." Thesis, Rhodes University, 2003. http://eprints.ru.ac.za/2317/1/MUSENGI-MCom-TR03-75.pdf.
Texte intégral
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Ismaili, Hami. "Multi-criteria Decision Support for Strategic Program Prioritization at Defence Research and Development Canada." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23996.
Texte intégralRésumé :
The objective of this thesis research is to model the multiple program objectives used by Defence Research and Development Canada (DRDC) for the annual management and allocation of their broad range of Science and Technology (S&T) projects in order to best achieve the strategic goals of the agency and the government.
This M.Sc. thesis presents methodologies, techniques and applications in Linear Programming (LP) and Multi-Criteria Decision Making (MCDM) for decision support in program prioritization and project selection of the DRDC S&T projects.
The results of this research produce a model that supports decision makers effectively in the assignment of limited human and financial resources to competing S&T projects based on the evaluation of projects that merit funding and the multiple criteria established by the organization. While there is a well-defined set of criteria for the annual program formulation process, the selection procedure is currently based on simple scoring processes and expert judgement; it lacks a well-defined and structured analysis. The application of an MCDM framework is proposed to take advantage of the well-structured problem and improve annual renewal and ongoing monitoring or project performance measures. The results of the analysis provide a traceable and rigorous MCDM framework to evaluate the performance of DRDC S&T projects for enhanced resource allocation.
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Gouvêa, Adriele Ferreira. "Analise da expressão de KI-67, P53, MCM 2 e MCM 5 em leucoplasia verrucosa proliferativa." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287853.
Texte intégralRésumé :
Orientador: Marcio Ajudarte Lopes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-10T15:16:37Z (GMT). No. of bitstreams: 1
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Previous issue date: 2008<br>Resumo: Leucoplasia verrucosa proliferativa é uma forma agressiva de leucoplasia oral, que afeta mais mulheres acima de 60 anos, sem história de etilismo e tabagismo. Tem apresentação clínica multifocal, mostra recorrência e sempre desenvolve displasia epitelial e carcinoma espinocelular (CEC). O objetivo deste trabalho foi avaliar os achados clínico-patológicos e a expressão imunohistoquímica de ki-67, p53, Mcm2 e Mcm5, na tentativa de elucidar o comportamento biológico distinto desta condição. Os dados clínico-patológicos de 12 pacientes foram revisados. Todos eram mulheres, acima de 50 anos (50% acima de 70 anos), 91,7% eram não fumantes e nenhuma etilista habitual. Os casos acompanhados por mais tempo mostraram aspectos clínicos compatíveis com lesões iniciais com presença de hiperqueratose e acantose, desenvolvimento de diferentes graus de displasia e CEC. Os locais mais acometidos foram rebordo alveolar (66,6%), língua (50%) e mucosa jugal (41,6%). Quatro pacientes desenvolveram CEC. Os achados imunohistoquímicos mostraram expressões variáveis em cada marcador. As áreas epiteliais sem displasia mostraram imunopositividade fraca para p53 e ki- 67 e moderada para Mcm2 e Mcm5; os casos de displasia leve tiveram expressão fraca de p53, moderada de ki-67 e Mcm5 e forte de Mcm2; displasia moderada exibiu marcação fraca de Mcm5 e de p53 e Mcm2, além de expressão moderada de ki-67; CEC mostrou expressão fraca de Mcm5, moderada de Mcm2 e forte de ki-67 e p53. Não foi observado, na maioria dos casos, um padrão regular de aumento de marcação imunohistoquímica conforme avanço do grau de displasia epitelial. A expressão de ki-67, Mcm2 e Mcm5 mostrou-se variada, com casos de displasias leves apresentando forte imunopositividade<br>Abstract: Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia that affects particularly women over 60 years of age, without tobacco and alcohol intake history. Has multifocal presentation, presents recurrences and always develops epithelial dysplasia and squamous cell carcinoma (SCC). The aim of this study was to evaluate the clinico-pathological findings and the ki-67, p53, Mcm2 and Mcm5 immunohistochemical expression, in order to elucidate the distinct biologic behavior of this condition. The clinico-pathological data of 12 patients were reviewed. All were women, above 50 years (50% above 70 years of age), 91.7% were non smoker and 100% were non-drinker. The cases with longer follow-up showed clinical aspects compatible with initial lesions presenting hyperkeratosis and acantosis, development of different grade of epithelial dysplasia and SCC. Alveolar ridge (66,6%), tongue (50%) and buccal mucosa (41,6%) were the most affected sites. Four patients developed SCC. The immunohistochemical findings showed variable expression for each antibody. Areas without epithelial dysplasia showed weak positivity to p53 and ki-67 and moderate to Mcm2 and Mcm5. Mild dysplasia cases showed weak positivity to p53, moderate to ki-67and Mcm5 and strong to Mcm2; moderate dysplasia exhibited weak p53, Mcm2 and Mcm5 expression and moderated ki-67 imunopositivity; SCC showed weak Mcm5 positivity, moderate expression of Mcm2 and strong imunopositivity of ki-67 and p53.The majority of the cases did not show a regular pattern of increasing immunohistochemical expression according to higher grades of epithelial dysplasia. Ki-67, Mcm2 and Mcm5 showed variable imunopositivity, with some mild dysplasia cases presenting strong expression<br>Mestrado<br>Patologia<br>Mestre em Estomatopatologia
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Gilani, Golshid. "MCDM approach for assessing the sustainability of buildings' facades." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/669822.
Texte intégralRésumé :
Construction industry is known to cause major social, economic and environmental impacts on the society so that promoting sustainable construction practice affects positively and allows generating a balance among these pillars. Besides, to achieve sustainability goals in a building project, the stakeholders' needs and expectations have to be met and taken into consideration.
One of the main and largest components of a building, which could highly contribute to the sustainability performance of the whole building is the facade. Previous studies confirmed the predominant role of facades in minimizing environmental effects and decreasing buildings' costs as well as providing comfort for inhabitants.
Despite the impact of facades on sustainability, indicators that govern the performance of the pillars are often dismissed or, if considered, these are rather subjectively measured - especially those associated with the social requirement. On the other hand, the vast majority of the existing tools fail at considering stakeholders' satisfaction in the assessment and selection process of optimal facade systems.
Within this context, a new comprehensive approach to quantify the sustainability index of facade systems including the most representative economic, environmental and social indicators and integrating the stakeholders’ satisfaction was developed.
The approach is based on MIVES (Integrated Value Model for Sustainable Assessment), a Multi Criteria Decision Making (MCDM) model, which allows minimizing the subjectivity in the decision-making process and relies on the value function concept.
This new approach was particularly optimized for residential building facades and successfully validated by analyzing five residential facade systems commonly used in Barcelona. The model is applicable for other countries and cities as well. Furthermore, through assessing the sustainability of two real buildings and validating the goodness of the results, the applicability of this approach was demonstrated.
The results proved several capabilities and potentials of the model, these being: (1) quantify, objectively, the sustainability of facade systems from the economic, environmental and social perspectives involving the stakeholders’ preferences and (2), identify strengths and weaknesses of facades that would allow implementing improving measures.
The proposed approach was designed to be a decisive support for decision-making in the field of facade management. Findings confirm that the approach is valuable and suitable for use in practice by public and private stakeholders. Future works could be to develop a digital application for building and architectural offices so that these could consider sustainability in the design, assessment and selection processes of facades to make the best decision. Next research steps could also adapt this approach to other types of buildings in order to move towards more sustainable architecture and construction.<br>Es sabido que la industria de la construcción causa importantes impactos sociales, económicos y ambientales en la sociedad, por lo que promover prácticas de construcción sostenibles tiene efectos positivos y permite generar un equilibrio entre estos tres pilares de la sostenibilidad. Además, para lograr los objetivos de sostenibilidad en un proyecto de construcción, las necesidades y expectativas de las partes y profesionales implicados deben cumplirse y tomarse en consideración. Uno de los componentes principales y de más envergadura de un edificio, que podría contribuir en gran medida al comportamiento sostenible de todo el edificio es la fachada. Hay estudios previos que han confirmado el papel predominante de las fachadas a la hora de minimizar los efectos ambientales y disminuir los costos de los edificios, además de proporcionar comodidad a los habitantes. A pesar del impacto de las fachadas en la sostenibilidad, los indicadores que rigen el desempeño de los pilares a menudo se descartan o, si se consideran, se miden de manera bastante subjetiva, especialmente aquellos asociados con los aspectos sociales. Por otro lado, la gran mayoría de las herramientas existentes no tienen en cuenta la satisfacción de las partes interesadas en el proceso de evaluación y selección de sistemas de fachada óptimos. En este contexto, se ha desarrollado un nuevo modelo integral para cuantificar el índice de sostenibilidad de los sistemas de fachada, incluyendo los indicadores económicos, ambientales y sociales más representativos e integrando la satisfacción de las partes interesadas. El modelo se basa en MIVES, un modelo de toma de decisiones multi criterio (MCDM), que permite minimizar la subjetividad en el proceso de toma de decisiones y se basa en el concepto de función de valor. Este nuevo modelo ha sido especialmente optimizado para fachadas de edificios residenciales y validado con éxito mediante el análisis de cinco sistemas de fachadas residenciales de uso común en Barcelona. El modelo es aplicable a otros países y ciudades también. Además, al evaluar la sostenibilidad de dos edificios reales y validar la bondad de los resultados, se ha probado la aplicabilidad de este modelo. Los resultados han demostrado varias capacidades y potenciales del modelo, como son: (1) cuantificar, objetivamente, la sostenibilidad de los sistemas de fachada desde las perspectivas económicas, ambientales y sociales que involucran las preferencias de las partes interesadas y (2), identificar las fortalezas y debilidades de las fachadas, lo que permitiría implementar medidas de mejora. El enfoque propuesto ha sido diseñado para ser un soporte decisivo para la toma de decisiones en el campo de la gestión de fachadas. Los resultados confirman que el enfoque es valioso y adecuado para su uso en la práctica por parte de las partes interesadas públicas y privadas. Los trabajos futuros podrían ser desarrollar una aplicación digital para estudios de arquitectura y edificación para que estos estudios puedan considerar la sostenibilidad en los procesos de diseño, evaluación y selección de fachadas con el objetivo de tomar la mejor decisión. Los próximos pasos de investigación también podrían adaptar este enfoque a otros tipos de edificios para avanzar hacia una arquitectura y construcción más sostenible.
15
Maida, Martina, Konradin Maier, Nikolaus Obwegeser, and Volker Stix. "Explaining MCDM acceptance: a conceptual model of influencing factors." IEEE Digital Library, 2011. http://epub.wu.ac.at/3719/1/33.pdf.
Texte intégralRésumé :
The number of newly developed Multi-Criteria Decision Making (MCDM) methods grew considerably in the last decades. Although their theoretical foundations are solid, there is still a lack of acceptance and application in the practical field. The objective of this research is the development of a conceptual model of factors that influence MCDM acceptance that serves as a starting point for further research. For this purpose, a broad diversified literature survey was conducted in the discipline of technology adoption and related topics (like human computer interaction) with special focus on MCDM acceptance. The constructs collected within the literature survey were classified based on a qualitative approach which yielded a
conceptual model structuring the identified factors according to individual, social, technology-related, task-related and facilitating aspects. (author's abstract)
16
Barry, E. R. "Functional analysis of Sulfolobus solfataricus MCM." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596432.
Texte intégralRésumé :
The minichromosome maintenance (MCM) complex is thought to function as the replicative helicase in eukaryotes and archaea. It is a member of the AAA+ (ATPases associated with various cellular activities) protein family. In this thesis, I demonstrated that the isolated AAA+ domain of <i>Sulfolobus solfataricus </i>MCM is a functional helicase, however its catalytic properties are very different to those of the full length protein. The N-terminus of the protein is required to confer substrate specificity on the enzyme, and also to enhance processive helicase activity. Communication between DNA binding sites in the N- and C-termini of the protein is shown to depend on a highly conserved loop, which protrudes from the N-terminus of the protein towards the AAA+ domain, where it interacts with a DNA binding β-hairpin in a dynamic, nucleotide dependent manner. This communication is mediated between, rather than within, allowing a model to be proposed for how helicase activity is co-ordinated; both between DNA binding sites within subunits, but also between subunits around the ring. Finally, I investigated reports of phosphorylated forms of MCM <i>in vivo</i> and identify a phosphorylated serine residue in the AAA+ domains of endogenous <i>S. solfataricus </i>MCM. Mutant forms of the protein with phosphomimetics at this site have elevated helicase activity <i>in vitro</i>. To identify the kinase responsible, several <i>S. solfataricus </i>kinases are investigated biochemically, and one is identified which has high levels of kinase activity on MCM. This is shown to interact with MCM <i>in vivo</i> and to be regulated in a cell cycle dependent manner.
17
McGeoch, Adam Thomas. "Mutational analysis of an archaeal MCM." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612891.
Texte intégral
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MEDEIROS, Cláudia Dourado. "Desenvolvimento de Peneiras Moleculares MCM-41 E Al-MCM-41, via processo hidrotermal assistido por micro-ondas." Universidade Federal de Campina Grande, 2014. http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/527.
Texte intégralRésumé :
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Previous issue date: 2014-04-02<br>Capes<br>As peneiras moleculares mesoporosas possuem um arranjo hexagonal de
mesoporos com diâmetros de poros que variam de 2 a 10 nm, possuindo assim uma
área superficial elevada. A adição de um metal a sua estrutura tem como função
gerar a acidez ao material o tornando mais reativo, aumentado assim a possibilidade
do seu uso como catalisador na indústria do petróleo. Atualmente, um dos
problemas encontrados pelos pesquisadores para obtenção desse tipo de peneira, é
o longo tempo de formação das estruturas. No presente trabalho as peneiras
moleculares mesoporosas MCM-41 e Al-MCM-41 foram sintetizadas utilizando dois
processos hidrotermais, a tradicional e por micro-ondas, com o objetivo principal de
reduzir o tempo de síntese do material. A peneira molecular MCM-41 foi sintetizada
utilizando o processo hidrotermal tradicional, 100 oC por 48 horas , como também
utilizando o processo hidrotermal de micro-ondas através de três metodologias,
adotando diferentes tempos e temperaturas. Tomando como base os resultados
obtidos com as sínteses da peneira molecular MCM-41 por meio do método
hidrotermal de micro-ondas, os mesmos métodos foram aplicados para a peneira
molecular Al-MCM-41 nas mesmas condições de tempo e temperatura. Através dos
difratogramas foi possível perceber que a estrutura hexagonal foi formada. Verificouse
que o melhor tempo de síntese da Al-MCM-41 se deu com 60 minutos a 130 oC.
A partir destes dados, foram realizadas novas sínteses, reduzindo o tempo
gradativamente. Os resultados das análises de DRX, MEV e FTIR comprovam que
as peneiras moleculares mesoporosas foram formadas, sendo possível identificar
sua estrutura e morfologia. Os melhores resultados de síntese para as peneiras
moleculares mesoporosas MCM-41 e Al-MCM-41, foram nos tempos 60 e 40
minutos e temperatura de 130 oC, respectivamente.<br>The mesoporous molecular sieves have a hexagonal arrangement of
mesopores with pore diameters ranging from 2 to 10 nm, which implies in a high
surface area. The addition of a metal into these structures has the function of
generating acidity in the material making it more reactive, increasing the possibility of
using it as a catalyst into the oil industry. Nowadays, one of the problems found by
researches to obtain these type of molecular sieves is the long time of structure
formation taken by these materials. In this study, the mesoporous molecular sieves
MCM - 41 and Al -MCM -41 were synthesized using two traditional microwave, with
the primary goal of reducing the time of synthesis of the material hydrothermal
processes. The molecular sieve MCM -41 was synthesized using the traditional
hydrothermal process 100 °C for 48 hours , as well as hydrothermal process using
microwave by three methods , adopting different times and temperatures . Based on
the results obtained with the synthesis of molecular sieve MCM -41 by hydrothermal
microwave method, the same methods were applied to the molecular sieve Al -MCM
-41 under the same conditions of time and temperature. Through the DRX patterns
was observed that the hexagonal structure was formed. It was found that the best
time of synthesis of Al- MCM-41 was given 60 minutes at 130 oC. From these data,
new syntheses were carried out by reducing the time gradually. The results of DRX,
MEV and FTIR show that the mesoporous molecular sieves were formed, it is
possible to identify their structure and morphology. The best results for the synthesis
of mesoporous molecular sieves MCM - 41 and Al -MCM -41, were at times 60 and
40 minutes and temperatures of 130 °C, respectively.
19
Shaikh, Rehan. "Mobile CRM (mCRM) : A CASE STUDY OF MOBILE CRM STRATEGIES." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177536.
Texte intégralRésumé :
Mobile technology has evolved drastically over the years, and so has the customer’s perception of and expectations on mobile services. Mobile phones have become the essential part of customer’s life style and they expect consumer services to be available on mobile phone. In this saturated market, providing better customer experience through the channel preferred by customers is as important as selling the actual product or services. In the quest to retain existing customers as well as attracting new, companies are developing innovative mobile customer relationship management (mCRM) strategies to strike a balance between its investments and fulfilling of customers need to generate maximum profit. However, not all mCRM strategies succeed leaving customers dissatisfied and switching to competitors providing better mobile services. The purpose of this study is to understand the dynamics between the customer acceptance, customer satisfaction and customer loyalty in the context of mCRM services. Thus, answering the following research questions: a) What are the factors behind customer acceptance? b) Do mCRM services have any effect on customer loyalty? Qualitative research method were utilized to closely study two different mCRM strategies from different industries with costumer in focus. Data for the study was gathered from a costumer survey as well as from interviews with informants within the company. In addition, external data from public domain was used to validate the findings of the study. Furthermore, a research model was developed by identifying the constructs adopted from literature study of technology acceptance model (TAM3) and customer loyalty. The research model was the basis for developing the customer feedback survey. In addition, the constructs helped in identifying the impact on customer acceptance and customer loyalty for the respective mCRM strategy. This study confirms previous findings and contributes to our understanding of technology acceptance as well as customer loyalty. The study reveals that mCRM services are mostly useful to urban customers with busy and on-the-go lifestyle. Furthermore, the study shows that through well practice use behavior customer develops a habit based on the prior evaluation of perceived usefulness and perceived value. In addition, the study indicates that customers build up a new trust towards the mCRM services through the usage of the service. Finally, the results of the study indicate that the mCRM services have an impact on company’s net customer loyalty.
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Chevalier-Boisvert, Maxime. "McVM: An optimizing virtual machine for the MATLAB programming language." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86850.
Texte intégralRésumé :
In recent years, there has been an increase in the popularity of dynamic languages such as Python, Ruby, PHP, JavaScript and MATLAB. Programmers appreciate the productivity gains and ease of use associated with such languages. However, most of them still run in virtual machines which provide no Just-In-Time (JIT) compilation support, and thus perform relatively poorly when compared to their statically compiled counterparts. While the reference MATLAB implementation does include a built-in compiler, this implementation is not open sourced and little is known abouts its internal workings. TheMcVMproject has focused on the design and implementation of an optimizing virtual machine for a subset of the MATLAB programming language.<br>Virtual machines and JIT compilers can benefit from advantages that static compilers do not have. It is possible for virtual machines to make use of more dynamic information than static compilers have access to, and thus, to implement optimization strategies that are more adapted to dynamic languages. Through theMcVMproject, some possible avenues to significantly improve the performance of dynamic languages have been explored. Namely, a just-in-time type-based program specialization scheme has been implemented in order to take advantage of dynamically available type information.<br>One of the main contributions of this project is to provide an alternative implementation of the MATLAB programming language. There is already an open source MATLAB interpreter (GNU Octave), but our implementation also includes an optimizing JIT compiler and will be open sourced under the BSD license. McVM aims to become a viable implementation for end-users, but could also see use in the compiler research community as a testbed for dynamic language optimizations. In addition to the contribution of the McVM framework itself, we also contribute the design and implementation of a novel just-in-time type-based program specialization system aimed at dynamic languages.<br>The novel specialization system implemented in McVM shows much promise in terms of potential speed improvements, yielding performance gains up to 3 orders of magnitude faster than competing implementations such as GNU Octave. It is also easily adaptable to other dynamic programming languages such as Python, Ruby and JavaScript. The investigation of performance issues we make in this thesis also suggests future research directions for the design of dynamic language compilers of the future.<br>Ces dernières années, il y a eu une augmentation de la popularité des langages dynamiques tels que Python, Ruby, PHP, JavaScript et MATLAB. Les programmeurs apprécient les gains de productivité et la facilité d'utilisation associée à ces langues. Cependant, la plupart de ces langages s'exécutent encore dans des machines virtuelles qui ne fournissent aucun support pour la compilation à la volée, et ont donc une performance inférieure si on les compare à leurs homologues compilés statiquement. Bien que l'implémentation de référence de MATLAB comprenne un compilateur intégré, cette application n'est pas open source et son fonctionnement interne demeure un secret industriel. Le projet McVM a mis l'accent sur la conception et l'implémentation d'une machine virtuelle optimisée pour un sous-ensemble du langage de programmation MATLAB.<br>Les machines virtuelles et les compilateurs à la volée peuvent bénéficier d'avantages que les compilateurs statiques n'ont pas. Il est possible pour les machines virtuelles de faire usage d'informations dynamique à laquelle les compilateurs statiques n'ont pas accès, et donc, de mettre en oeuvre des stratégies d'optimisation qui sont plus adaptées aux langages dynamiques. à travers le projet McVM, plusieurs avenues possibles pour améliorer considérablement la performance des langages dynamiques ont été explorées. Entre autre, un système de spécialisation de programmes à la volée permettant de profiter d'informations sur les types disponible dynamiquement a été implémenté.<br>L'une des principales contributions de ce projet est de fournir une implémentation alternative du langage de programmation MATLAB. Il existe déjà un interpréteur MATLAB open source (GNU Octave), mais notre application comprend également un compilateur à la volée optimisé et sera distribuée sous la licence open source BSD. McVM vise à devenir une implémentation viable pour les utilisateurs finaux, mais pourrait aussi être utilisée dans le milieu de la recherche sur les compilateurs comme outil d'expérimentation. En plus de la contribution du logiciel intégré McVM lui-même, nous avons également contribué à la conception et la réalisation d'un système de spécialisation de programme à la volée visant à l'optimisation des langages dynamiques.<br>Le système de spécialisation mis en oeuvre dans McVM se montre très prometteur en termes de potentiel d'améliorations de la vitesse d'exécution, permettant des gains de performance allant jusqu'à trois ordres de grandeur comparés aux implémentations concurrentes telles que GNU Octave. Il est également facilement adaptable à d'autres langages de programmation dynamique tels que Python, Ruby et JavaScript. L'examen des problèmes de performance que nous faisons dans cette thèse suggère aussi des pistes de recherche pour la conception des compilateurs de langages de programmation dynamiques de l'avenir.
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Harfield, Jake. "MCAM in Melanoma Metastasis: The Role of Putative Endocytosis Motifs." Thesis, Curtin University, 2021. http://hdl.handle.net/20.500.11937/85747.
Texte intégralRésumé :
Melanoma cell adhesion molecule (MCAM) is a marker of melanoma metastasis and contributes to melanoma progression but how MCAM is sorted and recycled through the cell is unknown. Two putative endocytosis motifs have been identified in the intracellular domain of MCAM. The generation of wild-type and mutant MCAM expressing Colo239F cells was explored in this thesis to determine the role of these endocytosis motifs in melanoma metastasis.
22
Mosadeghi, Razieh. "A Spatial Multi-Criteria Decision Making Model for Coastal Land Use Planning." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367691.
Texte intégralRésumé :
Modern planning theories encourage approaches that consider different stakeholders with a variety of discourse types and values to minimise politically motivated and single interest dominated decisions. Quantitative approaches such as Multi-criteria Decision Making (MCDM) techniques combined with GIS have been applied successfully in a number of land suitability analysis and environmental planning and management scenarios. The use of spatial MCDM techniques can improve the transparency and analytic rigor of the future land use decisions. In the last decade, applications of the MCDM techniques in GIS-based land suitability procedures have increased, however, applying these techniques at large-scale planning processes is rare. This highlights the need for examining how quantitative approaches such as MCDM techniques can integrate and therefore improve local planning and decision-making outcomes. This study is considered to be the first that by using a realistic and detailed set of criteria and group decision making, compares two MCDM techniques (analytical hierarchy procedure (AHP) Fuzzy AHP) in defining the extent of land-use zones at a large scale in Australia. The presented approach is particularly helpful in situation where local decision-makers are left with considerable room for discretion during the political transitions.
Consequently, this research examines the application of MCDM methods in local land use planning for a 17,500 ha area, controlled by four local government areas (LGAs) in the northeast Gold Coast, located in southeast Queensland, Australia.<br>Thesis (PhD Doctorate)<br>Doctor of Philosophy (PhD)<br>Griffith School of Environment<br>Science, Environment, Engineering and Technology<br>Full Text
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Ali, Baraa Abbas. "Sorption Of C8 Aromatics On Mcm-41." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12611983/index.pdf.
Texte intégralRésumé :
The discovery of MCM-41 materials have attracted substantial research attention due to the remarkable features of these materials including a narrow pore size distribution, high surface area, high pore volume, and high thermal and hydrothermal stability, as well as, parallel hexagonal arrangement of uniform cylindrical pores without pore channel intersection. These well-defined structural characteristics make them ideal media to study the adsorption, catalysis, ion exchange, and separation.
MCM-41 sample used in this study was synthesized in (Chemical Engineering Department, Gazi University). The MCM-41 was synthesized by using sodium silicate (0.0705 mol, 27% Silica) as a source of silica and surfactant cetyltrimethylammoniumbromides (CTMABr) (0.036 mol) as template. A characteristic feature of this direct hydothermal synthesis was relatively long synthesis time (96 hour at 120°<br>C).
MCM-41 was characterized by using XRD, and nitrogen physisorption analysis techniques. The characteristic peak in the low-angle region corresponding to 2&<br>#952<br>= 2.406°<br>was obtained for MCM-41 sample indicating high structural ordering of the MCM-41sample. The BET, surface area was found as (492.2 m /g), with an average pore diameter (25 Å<br>).
In this study the sorption equilibrium of C aromatics (p-xylene, m-xylene, o-xylene, and ethylbenzene ) on MCM-41 at different temperatures (30°<br>C, 50°<br>C, 65°<br>C, 80°<br>C) was investigated by using an automated gravimetric electrobalance system. It was found that the amounts of each sorbate (p-xylene, m-xylene, o-xylene, and ethylbenzene) adsorbed at a given relative pressure on MCM-41 decreased when the temperature of the adsorption isotherms increases.
The adsorption isotherms were type V, according to IUPAC isotherm classification due to the mesoporous nature of the MCM-41 sample. The hysteresis are associated with condensation-evaporation within a narrow distribution of mesopores with each adsorption isotherms. It was shown that as the temperature for the adsorption isotherms increases the size of hysteresis decreases for each sorbate. The volume of sorbates (V ) were obtained from the mass uptake at maximum relative pressure by taking the normal liquid density at the adsorption temperature for all sorbates. These values are significantly lower than that obtained from low-temperature nitrogen isotherm. The reason of this difference is that the density of the adsorbed phase is unlikely to be exactly the same as that of the liquid adsorptive and curvature of some isotherms at high relative pressure leads to uncertainty in the location of the upper limit for pore filling.
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Aftanasar, M. S. "Fabrication of rectangular waveguides using MCM technology." Thesis, University of Surrey, 2003. http://epubs.surrey.ac.uk/843298/.
Texte intégralRésumé :
Rectangular waveguide is known for its ability to propagate microwave signals with low loss in a wide range of microwave and millimetre-wave applications. Recent developments in these applications have focussed particularly on integration of different circuits and miniaturisation of modules; rectangular waveguide requires expensive fabrication methods and is replaced wherever possible with planar transmission lines. However, these have much higher losses. This research has investigated the feasibility of several low cost methods of fabricating dielectric-filled rectangular waveguide. The methods used are based on multichip module (MCM) technology. The technologies used to fabricate the waveguides are multichip module laminate (MCM-L) and multichip module ceramic (MCM-C) processes. In the MCM-L method, a PCB milling machine technique was used with PCB laminates designed for a multilayer process. With the MCM-C technology, two material types are used to fabricate dielectric-filled waveguide using multilayer thick film processing. The materials used are the photoetchable and photoimageable thick film pastes. The photoimageable thick film process was successfully used to fabricate H-plane offset waveguide filters. LTCC processing using Green Tape materials was also investigated for the dielectric-filled rectangular waveguide fabrication. The MCM-L and photoetchable thick film dielectric filled rectangular were fabricated in- house, whilst the photoimageable waveguide was fabricated by Hibridas as part of a collaborative project. The performances were tested using TRL calibration on the VNA, and a range of transitions, guides, and filters have been evaluated, including a 160-170 GHz bandpass filter. Key words: Dielectric-filled rectangular waveguide, MCM technology, photoetchable and photoimageable thick film technology, LTCC.
25
Ivetic, Aleksandar. "Analysis of MCM proteins in Drosophila melanogaster." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287900.
Texte intégral
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Moreau, Matthew Joseph. "A biophysical and biochemical investigation of MCM." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612169.
Texte intégral
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Santos, Danilo Oliveira. "Avaliação da versatilidade do MCM-41 funcionalizado." Universidade Federal de Sergipe, 2012. https://ri.ufs.br/handle/riufs/6054.
Texte intégralRésumé :
Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>In this work the mesoporous material MCM-41 was functionalized with 3-aminopropyltrimetoxysilane (APS) for several purposes such as adsorption of the remazol red dye, immobilization of lanthanide ions (Eu+3, Tb+3 or Gd+3), coordination with the 2,6-pyridinedicarboxylic acid (dpa) and immobilization of the complex [RuCl2(PPh3)2(Meo-bipy)]. The structural and textural properties of the MCM-41 and NH2-MCM-41 were characterized by absorption spectroscopy in the infrared region, thermal analysis, X-ray diffraction and nitrogen adsorption-dessorption. The adsorption capacity of NH2-MCM-41 was studied with Remazol Red dye. The following parameters were studied in the adsorption process: pH, temperature, adsorbent dosage and initial concentration. The desorption process was studied in a NaOH solution which different concentrations. The Freundlich isotherm model was found to be fit with the equilibrium isotherm data. Kinetics of adsorption follows the modified Avrami rate equation. The NH2-MCM-41 adsorbed 99,1 % of the dye in 360 minutes at 25 ºC. Data from X-ray diffractograms of the NH2-MCM-41-Ln(dpa) (Ln = Eu+3, Tb+3 or Gd+3) material indicated that the materials showed a hexagonal structure with a low degree of ordering. The insertion of the lanthanide ions was indicated by the shift of the amine group of APTS in the spectra of NH2-MCM-41-Ln. The coordination of dpa to NH2-MCM-41-Ln (Ln = Eu+3, Tb+3 or Gd+3) materials was evidenced by the shift of the bands of COH and COO-. The elemental analysis indicated the coordination in the ratio 1:3 (metal:dpa). The nitrogen adsorption analysis shows that with changes in MCM-41, the surface area, pore volume and diameter of the material decreased indicating the immobilization of ions lanthanides and dpa within the pores of the mesoporous material. The evaluation of the triplet level of the ligand, from the spectra of the NH2-MCM-41-Gd(dpa)3 shows that their position favors the energy transfer of metal to ligand for NH2-MCM-41-Eu(dpa)3 material, however the NH2-MCM-41-Tb(dpa)3 material this process is complicated due to the triplet level of ligand is below the issuing level of the Tb+3 ion. Data from X-ray diffractograms of NH2-MCM-41-[RuCl(PPh3)2(Meo-bipy)] showed a hexagonal structure with a low degree of ordering. In addition, the adsorption spectra in the infrared region of the immobilized complex have a displacement in the band 1612 cm-1 characteristic of the ruthenium complex. The thermogravimetric analysis showed that the complex immobilized on the functionalized MCM-41 present high thermal
stability compared to free complex. The nitrogen adsorption analysis showed that surface area, pore volume and diameter of the NH2-MCM-41-[RuCl(PPh3)2(Meo-bipy)] are smaller than for the NH2-MCM-41, indicating the immobilization the complex within the pores of the NH2-MCM-41. Catalytic tests for reduction of ketones were carried out with the [RuCl2(PPh3)2(Meo-bipy)] complex. For acetophenone and sulcatone, [RuCl2(PPh3)2(Meo-bipy)] proved to be a good catalyst with 90.50 % and 33.95 % conversion, respectively.<br>Neste trabalho, o material mesoporoso MCM-41 foi funcionalizado com 3-aminopropilmetoxisilano (APTS) para diversas finalidades como, adsorção do corante vermelho de remazol, imobilização de íons lantanídeos (Eu+3, Tb+3 ou Gd+3), coordenação com o ácido 2,6-piridina-dicarboxílico (dpa) e imobilização do complexo [RuCl2(PPh3)2(Meo-bipy)]. As propriedades estruturais e texturais do MCM-41 e do NH2-MCM-41 foram caracterizados por espectroscopia de absorção na região do infravermelho, análise térmica, difratometria de raios-X e adsorção-dessorção de nitrogênio. A capacidade de adsorção do corante vermelho de remazol foi avaliada com o NH2-MCM-41. Os seguintes parâmetros foram estudados: pH, temperatura, dose do adsorvente e concentração do corante. O processo de dessorção foi examinado em solução aquosa de NaOH em diferentes concentrações. O modelo de isoterma de Freudlich obteve maior adequação ao processo de adsorção e a cinética de adsorção seguiu o modelo modificado de Avrami. O NH2-MCM-41 adsorveu 99,1 % do corante em 360 minutos a 25 ºC. Os dados dos difratogramas de raios-X dos materiais NH2-MCM-41-Ln(dpa) (Ln = Eu+3, Tb+3 ou Gd+3), indicaram que estes materiais apresentaram estruturas hexagonais com baixo grau de ordenação. A inserção dos íons lantanídeos foi indicada pelo deslocamento da banda do grupo amina do APTS nos espectros do NH2-MCM-41-Ln. A coordenação do dpa aos materiais NH2-MCM-41-Ln (Ln = Eu+3, Tb+3 ou Gd+3) foi evidenciada através do deslocamento das bandas do COH e do COO-. A análise elementar indicou a coordenação na proporção 1:3 (metal: dpa). A análise da adsorção de nitrogênio revela que com as modificações no MCM-41, a área superficial, diâmetro e volume de poros dos materiais diminuíram indicando a imobilização dos íons lantanídeos e do dpa no interior dos poros do material mesoporoso. A avaliação do nível tripleto do ligante, a partir do espectro do NH2-MCM-41-Gd(dpa)3, demonstra que sua posição favorece a transferência de energia ligante-metal para o material NH2-MCM-41-Eu(dpa)3, entretanto, para o material NH2-MCM-41-Tb(dpa)3 este processo é dificultado devido o nível tripleto do ligante está abaixo do nível emissor do íon Tb+3. Os dados de difratogramas de raios-X do NH2-MCM-41-[RuCl(PPh3)2(Meo-bipy)] evidenciaram uma estrutura hexagonal com baixo grau de ordenação. Além disso, o espectro de absorção na região do infravermelho do complexo imobilizado apresenta um deslocamento na banda em 1612 cm-1 característica do complexo de rutênio. As análises termogravimétricas demonstram que os complexos imobilizados no MCM-41 funcionalizado apresentam elevada estabilidade térmica comparada com a do complexo livre. Os dados da adsorção de nitrogênio demonstraram que a área superficial, diâmetro e volume de poros do NH2-MCM-41-[RuCl(PPh3)2(Meo-bipy)] são menores que para o NH2-MCM-41, indicando a eficiência no processo de imobilização do complexo no interior dos poros do NH2-MCM-41. Testes catalíticos para redução de cetonas foram realizados com o complexo [RuCl2(PPh3)2(Meo-bipy)]. Para a acetofenona e sulcatona, o [RuCl2(PPh3)2(Meo-bipy)] mostrou-se ser um bom catalisador com 90,50 % e 33,95 % de conversão, respectivamente.
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Sherman, Daniel A. "Assembly of the Schizosaccharomyces pombe MCM complex /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9951421.
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Medineckiene, Milena. "Integrated decision making in civil engineering, based on multi-criteria assessment and buildings’ certification." Doctoral thesis, KTH, Byggnadsteknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-200946.
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Significant investments are being made in the construction sector in order to raise the quality of the buildings and make them more sustainable and energy-efficient. The key aspect of these investments should be the purposeful optimization of the possible renovation and construction measures. However, this important matter usually is being pushed aside in favor of construction price and/or quality. Nevertheless, there are plenty of criteria that play a major role in building sustainable development. The main purpose of this study is to present a tool that combines multi-criteria decision making (MCDM) methods and building certification systems in order to make weighted decisions in complicated construction tasks. For this, a decision making model was developed with a focus on sustainability, buildings’ life cycle, MCDM methods, and building certification. The first section of this thesis, the introduction, discusses the importance of the investigated area, and the main objectives, tasks, and structure of the thesis. A literature review is presented in Section 2 – Theory. The main works in the area of sustainability, LCA, building certification, and MCDM are collected to show their role and importance and how they interact in the construction industry. Section 3 presents and discusses the main ideas and instructions of the proposed decision making model. Section 4 (Methodology) introduces the main existing and proposed techniques that I have used to implement the study. Sections 5 and 6 are the case studies, which demonstrate how the proposed methods can be used in practice. Final conclusions and recommendations are presented in Section 7.<br><p>QC 20170209</p><br>Funded by L.E. Lundberg foundation
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Tiesmeier, Dominique Katlin. "MCDM problem-structuring framework and a real estate decision support model." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/mcdm-problemstructuring-framework-and-a-real-estate-decision-support-model(a3376b20-6d3c-4b78-9aac-e645b454ad51).html.
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The real estate selection process might be regarded as a typical Multi-Criteria Decision Making (MCDM) problem. With current literature concentrating predominantly on institutional investment decision making, additional effort should be directed towards studying inexperienced homebuyers who want to buy a property in which to live. In this context, authors have described the decision environment as a complex decision process with restricted access to property data, high financial burdens partially due to the illiquid nature of the investment, the unfamiliarity with the decision task and low transparency in information aggregation. Consequently, this situation could benefit from a more structured approach that assists homebuyers in their actions. In order to guide the decision making process and provide a suitable support mechanism, it is necessary to first structure the problem and extract the required information. A thorough literature review shows that little guidance is available for MCDM problem structuring. Consequently, this research first proposes an MCDM problem-structuring framework to decompose complex problems into smaller parts. Foremost, the application is intended for high-involvement consumer products and services. This framework is derived from MCDM and methodology literature, where the former provides the elements that need to be defined in any MCDM problem situation, and the latter suggests suitable data collection and analysis methods to obtain the information. As a result, the first contribution to existing literature is the introduction of an MCDM problem-structuring framework, which consists of a carefully designed sequential exploratory mixed method procedure. Next, following the proposed structure, the real estate selection problem in Majorca (Spain) is defined. Whilst providing the inherent problem elements and establishing a comprehensive list of evaluation criteria to assess luxury properties, the fieldwork also offers behavioural insights, contributing and supplementing existing real estate research. In particular, major misunderstandings and false assumptions during real estate agent and client interactions are observed, stressing the need to optimise communication and targeting strategies. On the basis of the relevant real estate evaluation criteria, a dataset of alternative houses is created and subsequently rated by prospective luxury-homebuyers. This provides the basis for the third research focus, the construction of a decision support model for real estate selection. In accordance to the problem features and model requirements, the Evidential Reasoning (ER) rule is identified to offer a powerful and transparent evidence aggregation process, with the potential to have a superior performance than other methods in addressing the selection decision. Due to the ER rule’s short history (2013), application studies in general are practically non-existing and unprecedented in the real estate domain. Therefore, the use of a modified ER model can provide the real estate literature with a prescriptive multi-criteria decision support mechanism, whilst simultaneously offering an application study for the MCDM community and other relevant decision analysis domains. In closing, modelling a real problem using the ER rule highlights the method’s advantages and might in turn increase awareness, leading to more applications.
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Lundström, Edvin, and Carl Svensson. "Including ESG concerns in the portfolio selection process : An MCDM approach." Thesis, KTH, Optimeringslära och systemteori, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-146745.
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In recent years investors in the financial markets around the globe have begun to focus on non-financial factors in their portfolio selection processes. Three main areas of concerns are: Environmental, Social and corporate Governance (ESG). Previous research has mainly focused on implementing these concerns using qualitative methods, e.g. negative screening. Our thesis integrates these concerns in a Multi-Criteria Decision-Making (MCDM) framework, making it possible for investors to view the portfolio selection as a trade-o_ between three criteria: Return, Risk and ESG. This extends the traditional Markowitz frontier from two to three dimensions. Companies included are the ones in the index OMXS30. Return and risk are estimated using the single-index model. The ESG criterion is implemented as a linear function and estimated using two public ESG indices. We will use two different optimization methods, the weighted sum approach and the "-constraint method to compute the efficient frontier. These are evaluated and we conclude that each method has its own strengths and weaknesses. We can see that integrating ESG concerns as a third objective in addition to risk and return alters the portfolio selection process. It increases the complexity of choosing a portfolio, but also yielding a better decision basis for the investor. To mitigate the increase of complexity we propose the ESG-to-variability ratio in analogy with the Sharpe ratio, effectively reducing the number of portfolios an investor should consider.<br>Under senare år har investerare på världens finansiella marknader fått upp ögonen för icke-finansiella faktorer och hur dessa kan inkluderas i portföljvalsprocessen. Tre områden står i fokus: miljö-, sociala och bolagsstyrningsfrågor (på engelska förkortat ESG). Tidigare forskning har framför allt fokuserat på hur dessa faktorer kan implementeras genom att använda kvalitativa metoder som t.ex. negativ screening. Vår uppsats integrerar dessa faktorer i ett Multi- Criteria Decision-Making (MCDM) framework, vilket möjliggör för investerare att se på portföljvalsprocessen som en avvägning mellan tre kriterier: Avkastning, Risk och ESG. Detta leder till att den traditionella Markowitzfronten utökas från två till tre dimensioner. De företag som inkluderats ar de som ingår i OMXS30. Risk och avkastning skattades genom att använda singleindexmodellen. ESG kriteriet ar implementerat som en linjär funktion och skattat genom att använda två publika ESG-index. För att beräkna den effektiva fronten använder vi två optimeringsmetoder: the weighted sum approach och the ε-constraint method. Dessa utvärderas och vi drar slutsatsen att respektive metod har såväl styrkor som svagheter. Vi kan se att ett inkluderande av ESG som en tredje målfunktion, utöver risk och avkastning, förändrar portföljvalsprocessen. Komplexiteten vid portföljval ökar, samtidigt som investeraren får ett bättre beslutsunderlag. För att lindra ökningen av komplexitet så introducerar vi the ESG-to-variability ratio i analogi med Sharpe ratio, vilket effektivt reducerar antalet portföljer en investerare bör välja emellan.
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Jagannathan, Madhav. "Functional Characterization of the MCM Complex Binding Protein, MCM-BP." Thesis, 2014. http://hdl.handle.net/1807/65669.
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Complete and accurate DNA replication is essential to maintain the genetic integrity in all organisms. In eukaryotes, the minichromosome maintenance (MCM) complex forms the catalytic core of the CMG helicase that unwinds DNA at the replication fork. We have previously identified a conserved MCM complex binding protein (MCM-BP) through a proteomic screen in human cells. In chapter two of this thesis, I show that MCM-BP makes an important contribution to nuclear morphology in human cells by affecting centrosome duplication. I also show that MCM-BP depletion results in G2 checkpoint signaling and the induction of replication stress. A recent study in Xenopus egg extracts has suggested that MCM-BP functions to unload the MCM complex from chromatin during S-phase. However, the mechanism of this process remains enigmatic. In chapter three of this thesis, I show that MCM-BP directly binds the de-ubiquitylating enzyme, USP7 and that this interaction is mediated by S158 on MCM-BP and the USP7 TRAF domain. Furthermore, I indicate a novel role for USP7 in DNA replication that involves unloading of the MCM complex during S-phase. Finally, my data suggest that MCM-BP tethers an interaction between the USP7 and the MCM complex to facilitate MCM complex unloading at the end of S-phase.
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Chang, Kai-Jie, and 張凱傑. "Multi-Component Molding (MCM)." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/65614904538782820143.
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碩士<br>國立雲林科技大學<br>機械工程系碩士班<br>95<br>In the modern plastic molded product fabrication, multi-component molding (MCM) is one of the great methods to diversify the development. Due to its complicated nature and the unclear physical mechanism for the Multi-Component Molding (MCM) processes, more investigations on its thermomechanical behavior are needed. In this study, the product geometrical effects and material selections in MCM processes have been conducted. Due to the differences between two plastic materials and the mold metal, there are complex temperature and stress distributions during the molding process. Warpage caused by such uneven temperature distribution will be investigated. The effects of the processing conditions on the bonding strength and residual stresses are also studied.
During the second shot, the polymer melt was filled between first shot and mold metal and this resulted in uneven temperature distribution of the second shot polymer. The asymmetric residual stresses were built up and caused warpage of the final parts. Both CAE simulation and real experimental data showed quite similar tendency of the final warpage. Due to this effect, the final part tends to warp inward while the thicknesses of 2nd shot are larger than 0.5 mm. The larger the 2nd shot thickness, the higher the warpage.
Effects of different processing conditions on the bonding strengths were studied by the Taguchi’s design of experiments. Experiment results reveal that the higher the mold temperatures, the higher the bonding strengths. Mold temperature is the key factor to affect the diffusion behavior. The second significant factor is the melt temperature. Normal contact has higher bonding strength than the shear contact because normal contact has similar directions of the molecular orientation.
The residual stresses were measured by the photo-elasticity equipment. After the 2nd shot, the contact regions between two shots experience an annealing-like process. This results in reduction of the residual stresses of the 1st shot. On the other hand, the uneven temperature results in higher residual stresses and warpage of the second shot.
The present results are believed to help people better understand the mechanism and make the proper design to fabricate the modern MCM products.
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Lung, Chu-Mao, and 龍竹茂. "Subcontractor Selection for Construction Company using MCPM." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/g6trjw.
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碩士<br>國立臺灣科技大學<br>營建工程系<br>99<br>This research focuses on subcontractor selection decision for construction industry. The accuracy of critical factors on subcontractor selection decision affects the operating performance on the construction industry. The construction industry can no longer make decision by directly using lowest prices. However, it must have the complete evaluation and analysis after rethinking to select an appropriate subcontractor to reach the Project goal and the profit predefined for increase the company’s competition.
Has given this, this research for create industry who of practice demand, development out " Subcontractor Selection For Construction Company " main consider construction management in the duration and the cost two large frame factor for core, which reference related theory including has (Fuzzy Preference Relations, FPR) and (Cumulative Prospect Theory, CPT) makes construction industry which can for Subcontracting of the Project, application ”Multi-Criteria Prospect Model, MCPM”, derivation out expectations (Prospect Value), to as subcontractor selection of decision making.
By using the subcontractor selection decision models, the construction industry might integrate all assessments of company internal information within the company, on the subcontractors selecting by engineering firms which make the best judgment for the profit forecasting and project success probability implementation.
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Wu, Je-An, and 吳哲安. "MCDM in Portfolio Selection with Short Selling." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/97541547064279200979.
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碩士<br>國立暨南國際大學<br>資訊管理學系<br>97<br>The mean-variance model proposed by Markowitz (1952) becomes a foundation for the theory of the portfolio selection. Therefore, most studies have focused on the effect of long position but paid less attention on the behavior of short selling and other criteria. In this study, we propose three multi-criteria portfolio selection models based on the mean-variance model with criteria of return, risk, short selling, β and skewness. And the multiple objective programming is used to deal with multi-criteria decision making problems. Two examples based on the Taiwan stock market are utilized to assess the proposed model by adopting a rolling window approach to simulate a real-life transaction situation. And we found the proposed model with multiple criteria has higher profit than mean-variance model.
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Otaki, Chia, and 張嘉瀧. "A MCDM Model for Casino Service Quality." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/37288842530164120483.
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碩士<br>稻江科技暨管理學院<br>休閒遊憩與旅運管理學系碩士班<br>103<br>Abstract
The purpose of this study is to construct a decision making model for casino managers to improve the service quality. This paper uses decision making trial and evaluation laboratory (DEMATEL) and DEMATEL-based analytical network process (DANP) to explore the interrelationship and influential weights within dimensions/criteria. The empirical findings reveal that the criteria of casino service quality possessed a self-effect relationship based on DEMATEL technique. Based on the influential network relation map (INRM), the dimension that managers should improve first when improving casino service quality is tangibility. In the ten criteria, polite of casino personnel is the most important criterion, followed by providing exclusive services, understand customer needs, proper accounts, records accurate, dedicated service, prompt service, professionals, staff appearance, and environmental equipment.
Keywords: casino service quality, MCDM, DEMATEL, ANP
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YAN-LIANG, CHEN, and 陳彥良. "A MCDM Model for Exploring Casino Sites." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61708678678358601100.
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碩士<br>稻江科技暨管理學院<br>休閒遊憩管理學系碩士班<br>103<br>The purpose of this paper is to build a decision making model for casino managers to improve the casino sites. This paper uses decision making trial and evaluation laboratory (DEMATEL) and DEMATEL-based analytical network process (DANP) to explore the interrelationship and influential weights within dimensions/criteria. The empirical findings reveal that the criteria of casino sites possessed a self-effect relationship based on DEMATEL technique. According to the influential network relation map (INRM), the dimension that managers should improve first when improving casino sites is geographical features. In the ten criteria, tourist resources is the most important criterion, followed by waste disposal, ecological balance, transport facilitation, transport costs, labor supply, government policies, public support, location and land use.
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Yang, Yating, and 楊雅婷. "Using MCDM Evaluation Model of Convertible Bonds." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/55413025693108763926.
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碩士<br>開南大學<br>企業與創業管理學系<br>99<br>Evaluation model of convertible bonds is an important financial evaluation for financial investment in recent years; the model indicates that options pricing theory and pure bond theory are most commonly used method. But it did not explain the relative weight of these two methods and what are the sub-factor that will influence the methods. Therefore the purpose of this thesis is to discuss more in details, which evaluation of convertible bonds did not explain. This paper use DEMATEL (Decision Making Trial and Evaluation Laboratory), and ANP (Analytic Network Process) to establish the evaluation model. Our research also uses VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje) to selection convertible bonds in three firms of technology industry. The result shows that these two factors have the relationship of interdependence and feedback. In these eight evaluation criteria, the most important factor that will affect investment is the convertible price, followed by the underlying stock price and yield to maturity. In the selection of technology industry, the leading manufacturer B is the closet to investor’s aspired level.
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COSTA, ROSSELLA. "The role of the stem cell marker, melanoma cell adhesion molecule MCAM/CD146." Doctoral thesis, 2009. http://hdl.handle.net/11573/917900.
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CD146 is a transmembrane Ig-like glycoprotein identified as a marker of tumor progression and metastasis. More recently, Sacchetti et al. have identified CD146 as a marker of mesenchymal cell stemness related to the ability to regenerate bone and stroma and to establish the hematopoietic microenvironment. Some aspects concerning CD146 are still to be investigated: these include the identification of CD146 natural ligand and the mechanistic relationship between the protein and its patho-physiological role. To investigate on these questions, by genetically manipulating the expression of CD146, we produced a CD146 encoding lentivector and a set of CD146 interfering vectors. By using the interfering vectors, we assessed that CD146 plays a pivotal role in supporting proliferation of human and murine primary stem cells, as its absence alters their growth.
In order to shed light on CD146 patho-physiological role we investigated its molecular ligand by screening a random phage peptide library on CD146 over expressing (through a lentiviral vector) human mesenchymal stem cells or skeletal stem cells (hSSCs). After several rounds of biopanning we randomly isolated some phage clones which show (through an ELISA assay) a strong binding ability to hSSC CD146+ and recurrent amino acid motifs.
The isolated peptides were further characterized and a blast analysis was carried on. They didn’t show any sequence homology to MCAM/CD146 suggesting i) that CD146 could be involved both in a heterophilic and homophilic (as recently reported by Staquicini et al.) interactions and ii) that the isolated peptides could represent novel ligands of human mesenchymal stem cells. In vivo, we could successfully use a CD146 interfering vector, containing a puromycin resistance coding gene, to produce a knocked down mouse model. Currently, we have a second generation of mice that were genotyped at weaning and tested for mRNA expression at two months. 100% of the mice analysed was positive for provirus integration and a large percentage (almost 62% for F1) expressed the puromycin resistance gene. Moreover, more than 50% CD146 down regulation was observed in four F1 mice. In this context, we could define i) that interfered genotype can be inherited and ii) that CD146 down regulation is compatible with the mouse survival
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KHANNA, GRINIL, and 古逸. "A Fuzzy MCDM Approach on Determining Best Managers." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/93507411701283125307.
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碩士<br>南臺科技大學<br>商管專業學院<br>104<br>Human resources has been evolving from not just an administrative discipline, but increasingly oriented around building relationships and employee management strategy. Human resources is beginning to flex new muscles backed with people analytics and organizations are further realizing they are as strong as the people within them. Leading global companies are starting to ask questions such as, “How can we make our workers improve performance and work better together?” and, “What can we do to make our employees feel happier to work here?” Google released their results from a two year project which discovered the eight criteria that determines what makes a good manager at Google (Garvin, Kind, & Wagonfeld, 2013). This research paper demonstrates a Fuzzy Set Theory Multi-criteria Decision Making (MCDM) tool to define the best managers according to that eight criteria. This MCDM tool is built to work with qualitative as well as quantitative information. The alternatives being analyzed give fuzzy values which are then converted back into crisp values via a Maximizing Minimizing Set method (Chen, 1985). This allows to easily discern a ranking of the best managers using the initial input of a set of decision makers.
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Tai, Wei-Chun, and 戴偉峻. "A MCDM Method for Selecting an ERP System." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/21931060455018757625.
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碩士<br>國立中山大學<br>資訊管理學系研究所<br>90<br>In this e-commerce era, Enterprise Resource Planning (ERP) has been viewed as the entering cost for conducting the business and establishing contact with others. ERP system is very expensive and enormous complex package software, and applies the best business practice with partial adjustment and integration to suit for the operation of different enterprises. But due to the characteristics of high investement, high complexity and high risk of failure of ERP systems, misfits have been one of important issues for the implementation of ERP systems. Therefore, the selection of an appropriate ERP system has become the key factor leading to the eventual success of an ERP system implementation. And we select an appropriate ERP system by studing a case that uses ELECTRE I as evaluating tool.
This paper first identifies a set of evaluating criteria based on the extensive literature review and the considerat5ion of the environment and characteristics of ERP systems. Once the list was generated, an iterative process of personal interview with the consultant, suppliers, users and managers was conducted to modify the evaluating criteria in order to insure the integrity of it. The result of this study is not only can contribute to the understanding of the functionalities of an ERP system, but also can provide a practical guideline for the selection of an ERP system.
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ThiKy, Nguyen, and 阮氏紀. "Managing Customer Experience in RetailStores: Hybrid MCDM Approach." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/5b32j8.
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Liang, Yi-Jie, and 梁奕傑. "Using a Hybrid MCDM Model toSelect Green Suppliers." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/ww7sn6.
Texte intégralRésumé :
碩士<br>國立臺北科技大學<br>工業工程與管理系碩士班<br>101<br>International organizations concerning environmental protection have advocated that all products for environmental protection must be made and used properly by law as people, nowadays, have become more and more concerned about our mother nature. Therefore, many companies have been forced to implement Green Supply Chain Management. For recent years, academic thesis about this issue has been frequently discussed. However, the discussion of the environmental performance by Green Supply Chain Management doesn’t seem to be much. Thus, to model the study for the evaluation of the green suppliers, this study pointed out 12 criteria and 4 dimensions by the related references and the survey by the specialists. Through Multiple-criteria Decision Making, this study has confirmed the structural relation by using Decision Making Trial and Evaluation Laboratory (DEMATEL). And this study also combines this method with DEMATEL-based on Analytic Network Process (DANP) to find weights of criteria. At last, this study finds the optimal green supplier for the business manager. The finding suggests that green certifications be the most important criterion. Government regulation and environmental legal-compliance came in second priority. Experts think the regulation compliance is a basic requirement in the selection of suppliers. There are plenty of international environmental certification organizations, firms should first obtain the certificate to enter the green supply chain. This study can provide firms with selecting the optimal green suppliers. Decision makers can use this evaluation process to prioritize the suppliers. Finally, this study also can find out the key strategy of implementing Green Supply Chain Management.
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CHUANG, LI-CHIEN, and 莊立謙. "Use Fuzzy MCDM Approaches in the Policy Evaluation." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/u9kv65.
Texte intégralRésumé :
碩士<br>德明財經科技大學<br>物流管理系<br>102<br>This research focuses on the analysis of Taipei “White Paper on Transport Policy”, aiming to use Multiple Criteria Decision Making on policy evaluation model, for promoting policy planning and evaluation of reference. The research literature analysis is based on the report "Evaluation policy and guidelines for evaluations”; to advance the proposed evaluation criteria and to use Fuzzy Delphi survey questionnaire as a research tool. In this study, the transport policy experts include Taipei government civil service and academic experts. The research method uses Fuzzy Delphi Method (FDM), After analyzing the expert opinion, this study establishes transport policy evaluation framework divided into "efficiency", "effectiveness", "impact", "relevance" and "sustainability" forming the five main criteria as well as twenty guidelines. The results of this research will enable government officials in policy planning, policy-relevant research scholars and industry circles to implement policies related to contractors and other objects of reference.
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You, geng ming, and 游振明. "Investment Alternatives of Port Facilities by Using MCDM." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/50377559767957145936.
Texte intégral
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Chuang, Mei-Ling, and 莊梅菱. "Managing Airline Image and Reputation Using Fuzzy MCDM." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/44666837966356672563.
Texte intégralRésumé :
碩士<br>開南大學<br>空運管理學系碩士班<br>95<br>In today’s highly competitive marketing of air transportation, preferable airline images are acknowledged as having the potential to impact on customer loyalty toward the firm. Those images will not only influence frequent customers to choose familiar airlines in next flight, but also through the word-of-mouth, they will heavily impact on other potential customers’ purchasing behaviors who has not yet had experience with the airline. The management of airline image is a challenging task. If managed properly, positive airline images can add value to a firm in many ways. On the other hand, it would destroy an airline’s reputation and alienate their customers. Airline image provides a powerful way of differentiating with their competitors and stimulating purchase. However, the airline image is a vague concept and difficult to quantitative measurement in the past. Therefore, the objective of this paper is to provide a fuzzy MCDM (Multi Criteria Decision Making) model to quantified image of airlines so that management can fully comprehend the relative positioning of airlines in the market, make informed judgments about it and decisively act upon it.
The result of study shows that, both service quality and corporate image are important dimensions to the evaluation of experts and passengers; with regard to airlines which provide intangible service, they should pay much attention to both main dimensions which would be main actual-touched services by passengers. According to passengers’ evaluation, here we suggest each airline mentioned in this study to modify the parts where passengers consider to be strengthened, in order to stabilize passengers’ traveling options. In addition, as for the corporate image established by each airline, it could be found the most suitable competitive niche by corporate 's own advantage; to do different strategies base on different advantages and enterprise image of each airline, so as to make deep image for passengers, creating unusual enterprise image for the purpose of creating a win-win situation of profit.
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Hsu, Keng-We, and 許耿維. "A MCDM Method for Selecting an e-Store." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/27118592737207928360.
Texte intégralRésumé :
碩士<br>國立中山大學<br>資訊管理學系研究所<br>94<br>Since the internet opened for commercial use, more and more e-Stores are built on the World Wide Web .It is important to know which factors are the main concerns for the selection of an e-Store become the key points that our research institute will discuss next.
This paper first identifies a set of evaluating criteria concerning e-Store based on the extensive literature review, and the evaluating criteria for the option on e-Store is made after consideration of the environment and characteristics of e-Store. Then, an iterative process of personal questionnaires with the e-Store consumers was conducted to modify the evaluating criteria in order to ensure its integrity, and decide the importance of each of evaluating criteria. Secondly, we’ll choose an appropriate e-Store by studying a case with ELECTRE I as an evaluation method. The result of this research not only can contribute to the understanding of e-Store evaluation, but also provide a practical guideline for the enterprise that will introduced e-Store in the near future.
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Chiang, Cheng-hsin, and 江成欣. "MCDM Approach for Evaluating Effects in E-Learning." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/98894220490166028777.
Texte intégralRésumé :
碩士<br>國立交通大學<br>科技管理研究所<br>93<br>According to the development of Internet, plenty and useful information let e-learning becomes a trend of learning and training in 21st century. In recent years, USA, Europa and Taiwan, etc. has started to promote e-learning. They hope masses could learn what they want to know through Internet. Due to the promotion of e-learning, each corporation has started to promote e-learning, so the training costs could be reduced, the courses could reuse, and the learners could learn without any limitation. As a result, e-learning became a new method to do training in corporations. Therefore, how to evaluate the effectiveness of e-learning is a very important issue. For this purpose, according to literature review, this research found out 58 elements which are related to e-learning effects evaluation. Then, we adopted the factor analysis to categorize each element; the results are 9 main factors. Under each factor, we used DEMATEL method to determine the influence relationship of each element. After that, we adopted fuzzy integral to determine the weights of each element, and then use AHP method to calculate the final weights of 9 factors. We took Masterlink Securities Corp. as our empirical study, we chosen two courses as analysis targets. After the evaluation, the results could be shown that this e-learning evaluation model is applicable and it also indicated elements which need to be improved.
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林文雅. "Integration MOP and Fuzzy MCDM for Train Scheduling." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/21524436637030958961.
Texte intégralRésumé :
碩士<br>國立海洋大學<br>河海工程學系<br>91<br>Our work concerns the problem that the demand of passengers exceeds the capacity of the existing train schedule of Taipei Mass Rapid Transit. This article presents a model for the optimization of the tactical train schedules, which maximizes the level of the service and minimizes the risk of the operation. The model is an application of a multi-objective programming and a new approach of fuzzy measures named MOFA.
The research of MOFA is divided into two stages. The first stage is to create Application of Integration Model MOFA to Train Scheduling that is considered to maximize the level of service and minimize the risk of operation. We also examine it from several aspects such as the constraint of the signal system, the customer service, and the safety in this model. However, the conflict of trains at a terminal station has to be taken into consideration as well. The purpose of the first stage is to evaluate a lot of sets of the strategic headway (i.e. non-inferior), in which satisfies the preceding objectives and all the constraints. We could obtain several alternatives of headway by scenario approaching in this stage, and the result would apply to the next stage. The second stage is the extension of the first stage, which is an application of new fuzzy measures and fuzzy integrals approaching to calculate weights between the objectives. When we determine the weight of the objectives on decision-making problem. The approach of the fuzzy measures and fuzzy integrals, which Sugeno provided, always needs a lot of input information. Therefore, the new fuzzy measure approach needs fewer inputs to calculate the weights of an objective. We could evaluate the optimal solution for headway of train scheduling in this stage.
In the previous publications, the researchers focused on the conflict between two trains passing or meeting at a common section. Moreover, they only considered a single objective when they formulated a model of train scheduling. In our model, we both consider that the conflict between two trains passing or meeting at a common section in the strategic headway model, and also the satisfy multi-objective. Additionally, we apply the new fuzzy measure approach to dominate the alternatives. We also present the results of a computational study with the model. The processing techniques are tested based on the data from Taipei Mass Rapid Transit. The result of the case study will assist the dispatchers of Taipei MRT in their train schedule planning works.
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Sheng, Ni Yuan, and 倪源勝. "Hybrid MCDM Model for Improving Airport Service Quality." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/74512369931900772098.
Texte intégralRésumé :
碩士<br>開南大學<br>商學院碩士在職專班<br>102<br>Abstract
In this study, we applied new hybrid multiple criteria decision
making (MCDM) model. The model comprises decision-making trial
and evaluation laboratory (DEMATEL) to explore the interdependent
and feedback problems among criteria for building the influential
network relation map (INRM), DEMATEL-based ANP (DANP) to find
the influential weights, and VlseKriterijumska Optimizacija I
Kompromisno Resenje (VIKOR) combining DANP to evaluate and
improve the performance matrix of each alternative based on INRM for
achieving the greatest airport performances.
In this paper we have the following conclusion:the dimension of
assurance of international airport services is the major influence which
has impact on the tangibility; and the criterion of equipment and
comfortable is the critical to the airport service quality.
According to the empirical results, we provide the following
suggestions to the airport company: To implement a risk management
system for criteria safety inspection and automatic e-gate in order to
ensure the airport service quality; to establish the overall logistic
support management system；and to use the airport service quality
evaluation model to prove service quality.
Keywords: Airport Service Quality, MCDM, DEMATEL, DANP,
VIKOR, aspiration level