Littérature scientifique sur le sujet « Massa del top »

El INIFAP pone a disposición de los productores de trigo de riego la variedad ‘Conatrigo F2015’, obtenida en el Programa de Mejoramiento Genético de Trigo en el Campo Experimental Valle de México. Se cruzaron los progenitores Thelin y Weebill en El Batán en P-V/2001, la F1 se retrocruzó hacia WEEBILL en Cd. Obregón en O-I/2001-2002. La cruza F1 TOP (CGSS02Y00079T) se sembró en El Batán en P-V/2002, fueron cosechadas en forma masal un número indefinido de plantas (099B), este procedimiento se siguió alternadamente en El Batán, Atizapán y Cd. Obregón hasta la F5 que fue sembrada en Cd. Obregón, Son. en O-I/2004-2005, se seleccionó y cosecho individualmente la planta No. 6 (6Y) obteniéndose la línea que dio origen a la variedad. Del ciclo O-I/2007-2008 hasta O-I/2014-2015 fue evaluada por INIFAP en diez estados y hasta en 120condiciones diferente. Su genealogía es Thelin/2*Wbll1 y pedigrí, CGSS02Y00079T-099B-099B-099Y-099M-6Y-0B. el número de registro definitivo es TRI-174- 231117 y título de obtentor 1895. Posee los genes Lr24 y Lr46 que les otorgan resistencia a las razas de roya de la hoja presentes en México. Posee los genes Yr29 y Yr30 que le confieren resistencia en planta adulta a roya amarilla. Superó en rendimiento desde 3% (Kronstad F2004) hasta 32% (Palmerín F2004) en riego normal. Es de grano duro con masa fuerte (W> 300 J × 10-4), extensible (PL< 1), volumen de pan superior que el de Kronstad F2004, con masa adecuada para panificación mecanizada o como mejoradora de masas suaves y tenaces.

Abstract Background: CID occurs in up to 80% of patients with breast cancer who receive trastuzumab (H), pertuzumab (P), and a taxane, with grade 3 experienced by 8-12% of patients. Crofelemer is an extract of the Croton lechleri tree that inhibits luminal chloride efflux, implicated in the HP-related CID. We hypothesized crofelemer would prevent diarrhea in patients with HER2+ breast cancer receiving HP and docetaxel or paclitaxel, with/without carboplatin (THP or TCHP) in the neoadjuvant, adjuvant, or metastatic setting. Clinical trial information: NCT02910219. Methods: Adult patients with HER2+ any stage breast cancer, scheduled to receive at least 3 consecutive cycles of TCHP (docetaxel, carboplatin, trastuzumab and pertuzumab) or THP (trastuzumab and pertuzumab with paclitaxel or docetaxel), normal organ function, PS 0-2, who provided written informed consent were randomized 1:1 to receive crofelemer 125 mg PO 2x/day during cycles 1 and 2 of chemotherapy or no scheduled prophylactic medication. Randomization was stratified according to chemotherapy regimen. The primary endpoint was the incidence of CID of any grade for ≥2 consecutive days assessed by NCI CTCAE v4.0. Provider reported outcomes were collected during clinic visits and prospectively documented in clinical notes. Patient reported outcomes (PRO) were collected from patient diaries. Secondary endpoints were incidence of all grades and grade 3/4 CID by cycle/stratum; time to onset and duration of CID; stool consistency; frequency of break through anti-diarrheal medications use; and FACIT-D total score. Fisher’s exact test was used for comparing binary and categorical variables and summary statistics and Wilcoxon test for ordinal grade variables. The trial was designed to detect a 40% absolute decrease in incidence of CID (from 60% to 20%), two-sided significance level of 0.10. Results: A total of 53 patients were enrolled between 02/21/2017- 08/25/2020 on crofelemer (n=27) or control (n=26) arms. One patient withdrew consent prior to starting protocol procedures and was substituted. Early treatment discontinuation occurred in 7 cases: complications of diarrhea (n=1, control group), chemotherapy regimen changed for other cause than diarrhea (n=4) and non-compliance with trial procedures (n=2). 29 patients had early stage disease treated with TCHP; 23 patients had metastatic disease treated with THP (16 with paclitaxel and 7 with docetaxel). The primary endpoint was not statistically different between the two groups. The incidence of Grade 2 or greater diarrhea was 20.9% vs 26.4% of patients receiving crofelemer or placebo respectively in cycle 1, and 9.5% vs 41.1% in cycle 2 (Table). Results were consistent between provider assessments and patient reported outcomes (PRO). Detailed description of pooled cycle 1-2 data using correlated ordinal model and the additional secondary endpoints will be presented. Conclusions: Although there was no significant difference between crofelemer and control for diarrhea for 2 or more consecutive days in both cycles, there was a clinically meaningful difference between the crofelemer and control groups in maximum within-cycle diarrhea ordinal CTCAE grade diarrhea. These data are supportive for further testing of crofelemer in the ongoing randomized Phase 3 trial OnTARGET (NCT04538625). CycleCTCAE bCrofelemerControlPDiarrhea &gt;= 2 consecutive days a168.069.6NS d265.272.2Maximum diarrhea grade a1Grade 0 c33.321.1NS eGrade 145.852.6Grade 216.721.1Grade 34.25.3Grade 40.00.02Grade 0 c38.117.60.0261 eGrade 152.441.2Grade 29.523.5Grade 30.017.6Grade 40.00.0Maximum diarrhea grade PRO f1Grade 0 c4.08.7NS eGrade 172.039.1Grade 216.043.5Grade 38.08.7Grade 40.00.02Grade 0 c9.10.00.0361 eGrade 181.866.7Grade 24.522.2Grade 34.511.1Grade 40.00.0aProvider assessedbCTCAE: NCI Common Terminology Criteria for Adverse Events v4.0cGrade 0: no diarrheadFisher''s exact testeWilcoxon rank sum testfPRO: Patient reported outcomes Citation Format: Paula R Pohlmann, Deena Graham, Tianmin Wu, Yvonne Ottaviano, Mahsa Mohebtash, Shweta Kurian, Donna McNamara, Filipa Lynce, Robert Warren, Asma Dilawari, Suman Rao, Candace Mainor, Nicole Swanson, Ming Tan, Claudine Isaacs, Sandra M. Swain. Halt-d: A randomized open label phase 2 study of crofelemer for the prevention of chemotherapy induced diarrhea (cid) in patients with breast cancer receiving trastuzumab, pertuzumab, and a taxane [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P5-18-09.

<p>El texto resalta cómo el inconformismo de los sectores populares con el tradicionalismo político, liberal-conservador en Colombia y con las irregularidades en el conteo y reconteo de los votos en las elecciones presidenciales de 1970, pusieron en crisis al régimen político “frentenacionalista”, y a su candidato Misael Pastrana Borrero. Desde la historia política y social se analiza el papel de las masas y las posiciones y acciones de las elites para legitimar el poder; así, el evidente fraude electoral en las elecciones del 19 de abril de 1970 fue asumido por las masas como una burla al sistema democrático y a su expresión como ciudadanos, lo que motivó movilizaciones en diversas regiones del país. A partir de este hecho los actores sociales reivindicaron su papel como ciudadanos y reclamaron sus derechos, acudiendo a la denuncia en las diversas instituciones, a la movilización y a la protesta y, tres años después, a la movilización armada que se denominó M-19.</p><p> </p><p> </p><br /><table border="0" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="299"> </td><td valign="top" width="299"> </td></tr></tbody></table>

By most accounts, “resilience” is a pretty resilient concept. Or policy instrument. Or heuristic tool. It’s this last that really concerns us here: resilience not as a politics, but rather as a descriptive device for attempts in the humanities—particularly in rhetoric and cultural studies—to adequately describe a discursive event. Or rather, to adequately describe a class of discursive events: those that involve rhetorical resistance by victimised subjects. I’ve argued elsewhere (Munro, Descriptive; Reading) that Peircean semiosis, inflected by a rhetorical postulate of genre, equips us well to closely describe a discursive event. Here, I want briefly to suggest that resilience—“discursive” resilience, to coin a term—might usefully supplement these hypotheses, at least from time to time. To support this suggestion, I’ll signal some uses of resilience before turning briefly to a case study: a sensational Argentine homicide case, which occurred in October 2002, and came to be known as the caso Belsunce. At the time, Argentina was wracked by economic crises and political instability. The imposition of severe restrictions on cash withdrawals from bank deposits had provoked major civil unrest. Between 21 December 2001 and 2 January 2002, Argentines witnessed a succession of five presidents. “Resilient” is a term that readily comes to mind to describe many of those who endured this catastrophic period. To describe the caso Belsunce, however—to describe its constitution and import as a discursive event—we might appeal to some more disciplinary-specific understandings of resilience. Glossing Peircean semiosis as a teleological process, Short notes that “one and the same thing […] may be many different signs at once” (106). Any given sign, in other words, admits of multiple interpretants or uptakes. And so it is with resilience, which is both a keyword in academic disciplines ranging from psychology to ecology and political science, and a buzzword in several corporate domains and spheres of governmental activity. It’s particularly prevalent in the discourses of highly networked post-9/11 Anglophone societies. So what, pray tell, is resilience? To the American Psychological Association, resilience comprises “the process of adapting well in the face of adversity.” To the Resilience Solutions Group at Arizona State University, resilience is “the capacity to recover fully from acute stressors, to carry on in the face of chronic difficulties: to regain one’s balance after losing it.” To the Stockholm Resilience Centre, resilience amounts to the “capacity of a system to continually change and adapt yet remain within critical thresholds,” while to the Resilience Alliance, resilience is similarly “the capacity of a system to absorb disturbance and still retain its basic function and structure” (Walker and Salt xiii). The adjective “resilient” is thus predicated of those entities, individuals or collectivities, which exhibit “resilience”. A “resilient Australia,” for example, is one “where all Australians are better able to adapt to change, where we have reduced exposure to risks, and where we are all better able to bounce back from disaster” (Australian Government). It’s tempting here to synthesise these statements with a sense of “ordinary language” usage to derive a definitional distillate: “resilience” is a capacity attributed to an entity which recovers intact from major injury. This capacity is evidenced in a reaction or uptake: a “resilient” entity is one which suffers some insult or disturbance, but whose integrity is held to have been maintained, or even enhanced, by its resistive or adaptive response. A conjecturally “resilient” entity is thus one which would presumably evince resilience if faced with an unrealised aversive event. However, such abstractions ignore how definitional claims do rhetorical work. On any given occasion, how “resilience” and its cognates are construed and what they connote are a function, at least in part, of the purposes of rhetorical agents and the protocols and objects of the disciplines or genres in which these agents put these terms to work. In disciplines operating within the same form of life or sphere of activity—disciplines sharing general conventions and broad objects of inquiry, such as the capacious ecological sciences or the contiguous fields of study within the ambit of applied psychology—resilience acts, at least at times, as a something of a “boundary object” (Star and Griesemer). Correlatively, across more diverse and distant fields of inquiry, resilience can work in more seemingly exclusive or contradictory ways (see Handmer and Dovers). Rhetorical aims and disciplinary objects similarly determine the originary tales we are inclined to tell. In the social sciences, the advent of resilience is often attributed to applied psychology, indebted, in turn, to epidemiology (see Seery, Holman and Cohen Silver). In environmental science, by contrast, resilience is typically taken to be a theory born in ecology (indebted to engineering and to the physical sciences, in particular to complex systems theory [see Janssen, Schoon, Ke and Börner]). Having no foundational claim to stake and, moreover, having different purposes and taking different objects, some more recent uptakes of resilience, in, for instance, securitisation studies, allow for its multidisciplinary roots (see Bourbeau; Kaufmann). But if resilience is many things to many people, a couple of commonalities in its range of translations should be drawn out. First, irrespective of its discipline or sphere of activity, talk of resilience typically entails construing an object of inquiry qua system, be that system an individual, a community of circumstance, a state, a socio-ecological unit or some differently delimited entity. This bounded system suffers some insult with no resulting loss of structural, relational, functional or other integrity. Second, resilience is usually marshalled to promote a politics. Resilience talk often consorts with discourses of meliorative action and of readily quantifiable practical effects. When the environmental sciences take the “Earth system” and the dynamics of global change as their objects of inquiry, a postulate of resilience is key to the elaboration and implementation of natural resource management policy. Proponents of socio-ecological resilience see the resilience hypothesis as enabling a demonstrably more enlightened stewardship of the biosphere (see Folke et al.; Holling; Walker and Salt). When applied psychology takes the anomalous situation of disadvantaged, at-risk individuals triumphing over trauma as its declared object of inquiry, a postulate of resilience is key to the positing and identification of personal and environmental resources or protective factors which would enable the overcoming of adversity. Proponents of psychosocial resilience see this concept as enabling the elaboration and implementation of interventions to foster individual and collective wellbeing (see Goldstein and Brooks; Ungar). Similarly, when policy think-tanks and government departments and agencies take the apprehension of particular threats to the social fabric as their object of inquiry, a postulate of resilience—or of a lack thereof—is critical to the elaboration and implementation of urban infrastructure, emergency planning and disaster management policies (see Drury et al.; Handmer and Dovers). However, despite its often positive connotations, resilience is well understood as a “normatively open” (Bourbeau 11) concept. This openness is apparent in some theories and practices of resilience. In limnological modelling, for example, eutrophication can result in a lake’s being in an undesirable, albeit resilient, turbid-water state (see Carpenter et al.; Walker and Meyers). But perhaps the negative connotations or indeed perverse effects of resilience are most apparent in some of its political uptakes. Certainly, governmental operationalisations of resilience are coming under increased scrutiny. Chief among the criticisms levelled at the “muddled politics” (Grove 147) of and around resilience is that its mobilisation works to constitute a particular neoliberal subjectivity (see Joseph; Neocleous). By enabling a conservative focus on individual responsibility, preparedness and adaptability, the topos of resilience contributes critically to the development of neoliberal governmentality (Joseph). In a practical sense, this deployment of resilience silences resistance: “building resilient subjects,” observe Evans and Reid (85), “involves the deliberate disabling of political habits. […] Resilient subjects are subjects that have accepted the imperative not to resist or secure themselves from the difficulties they are faced with but instead adapt to their enabling conditions.” It’s this prospect of practical acquiescence that sees resistance at times opposed to resilience (Neocleous). “Good intentions not withstanding,” notes Grove (146), “the effect of resilience initiatives is often to defend and strengthen the political economic status quo.” There’s much to commend in these analyses of how neoliberal uses of resilience constitute citizens as highly accommodating of capital and the state. But such critiques pertain to the governmental mobilisation of resilience in the contemporary “advanced liberal” settings of “various Anglo-Saxon countries” (Joseph 47). There are, of course, other instances—other events in other times and places—in which resilience indisputably sorts with resistance. Such an event is the caso Belsunce, in which a rhetorically resilient journalistic community pushed back, resisting some of the excesses of a corrupt neoliberal Argentine regime. I’ll turn briefly to this infamous case to suggest that a notion of “discursive resilience” might afford us some purchase when it comes to describing discursive events. To be clear: we’re considering resilience here not as an anticipatory politics, but rather as an analytic device to supplement the descriptive tools of Peircean semiosis and a rhetorical postulate of genre. As such, it’s more an instrument than an answer: a program, perhaps, for ongoing work. Although drawing on different disciplinary construals of the term, this use of resilience would be particularly indebted to the resilience thinking developed in ecology (see Carpenter el al.; Folke et al.; Holling; Walker et al.; Walker and Salt). Things would, of course, be lost in translation (see Adger; Gallopín): in taking a discursive event, rather than the dynamics of a socio-ecological system, as our object of inquiry, we’d retain some topological analogies while dispensing with, for example, Holling’s four-phase adaptive cycle (see Carpenter et al.; Folke; Gunderson; Gunderson and Holling; Walker et al.). For our purposes, it’s unlikely that descriptions of ecosystem succession need to be carried across. However, the general postulates of ecological resilience thinking—that a system is a complex series of dynamic relations and functions located at any given time within a basin of attraction (or stability domain or system regime) delimited by thresholds; that it is subject to multiple attractors and follows trajectories describable over varying scales of time and space; that these trajectories are inflected by exogenous and endogenous perturbations to which the system is subject; that the system either proves itself resilient to these perturbations in its adaptive or resistive response, or transforms, flipping from one domain (or basin) to another may well prove useful to some descriptive projects in the humanities. Resilience is fundamentally a question of uptake or response. Hence, when examining resilience in socio-ecological systems, Gallopín notes that it’s useful to consider “not only the resilience of the system (maintenance within a basin) but also coping with impacts produced and taking advantage of opportunities” (300). Argentine society in the early-to-mid 2000s was one such socio-political system, and the caso Belsunce was both one such impact and one such opportunity. Well-connected in the world of finance, 57-year-old former stockbroker Carlos Alberto Carrascosa lived with his 50-year-old sociologist turned charity worker wife, María Marta García Belsunce, close to their relatives in the exclusive gated community of Carmel Country Club, Pilar, Provincia de Buenos Aires, Argentina. At 7:07 pm on Sunday 27 October 2002, Carrascosa called ambulance emergencies, claiming that his wife had slipped and knocked her head while drawing a bath alone that rainy Sunday afternoon. At the time of his call, it transpired, Carrascosa was at home in the presence of intimates. Blood was pooled on the bathroom floor and smeared and spattered on its walls and adjoining areas. María Marta lay lifeless, brain matter oozing from several holes in her left parietal and temporal lobes. This was the moment when Carrascosa, calm and coherent, called emergency services, but didn’t advert the police. Someone, he told the operator, had slipped in the bath and bumped her head. Carrascosa described María Marta as breathing, with a faint pulse, but somehow failed to mention the holes in her head. “A knock with a tap,” a police source told journalist Horacio Cecchi, “really doesn’t compare with the five shots to the head, the spillage of brain matter and the loss of about half a litre of blood suffered by the victim” (Cecchi and Kollmann). Rather than a bathroom tap, María Marta’s head had met with five bullets discharged from a .32-calibre revolver. In effect, reported Cecchi, María Marta had died twice. “While perhaps a common conceit in fiction,” notes Cecchi, “in reality, dying twice is, by definition, impossible. María Marta’s two obscure endings seem to unsettle this certainty.” Her cadaver was eventually subjected to an autopsy, and what had been a tale of clumsiness and happenstance was rewritten, reinscribed under the Argentine Penal Code. The autopsy was conducted 36 days after the burial of María Marta; nine days later, she was mentioned for the second time in the mainstream Argentine press. Her reappearance, however, was marked by a shift in rubrics: from a short death notice in La Nación, María Marta was translated to the crime section of Argentina’s dailies. Until his wife’s mediatic reapparition, Carroscosa and other relatives had persisted with their “accident” hypothesis. Indeed, they’d taken a range of measures to preclude the sorts of uptakes that might ordinarily be expected to flow, under functioning liberal democratic regimes, from the discovery of a corpse with five projectiles lodged in its head. Subsequently recited as part of Carrascosa’s indictment, these measures were extensively reiterated in media coverage of the case. One of the more notorious actions involved the disposal of the sixth bullet, which was found lying under María Marta. In the course of moving the body of his half-sister, John Hurtig retrieved a small metallic object. This discovery was discussed by a number of family members, including Carrascosa, who had received ballistics training during his four years of naval instruction at the Escuela Nacional de Náutica de la Armada. They determined that the object was a lug or connector rod (“pituto”) used in library shelving: nothing, in any case, to indicate a homicide. With this determination made, the “pituto” was duly wrapped in lavatory paper and flushed down the toilet. This episode occasioned a range of outraged articles in Argentine dailies examining the topoi of privilege, power, corruption and impunity. “Distinguished persons,” notes Viau pointedly, “are so disposed […] that in the midst of all that chaos, they can locate a small, hard, steely object, wrap it in lavatory paper and flush it down the toilet, for that must be how they usually dispose of […] all that rubbish that no longer fits under the carpet.” Most often, though, critical comment was conducted by translating the reporting of the case to the genres of crime fiction. In an article entitled Someone Call Agatha Christie, Quick!, H.A.T. writes that “[s]omething smells rotten in the Carmel Country; a whole pile of rubbish seems to have been swept under its plush carpets.” An exemplary intervention in this vein was the work of journalist and novelist Vicente Battista, for whom the case (María Marta) “synthesizes the best of both traditions of crime fiction: the murder mystery and the hard-boiled novels.” “The crime,” Battista (¿Hubo Otra Mujer?) has Rodolfo observe in the first of his speculative dialogues on the case, “seems to be lifted from an Agatha Christie novel, but the criminal turns out to be a copy of the savage killers that Jim Thompson usually depicts.” Later, in an interview in which he correctly predicted the verdict, Battista expanded on these remarks: This familiar plot brings together the English murder mystery and the American hard-boiled novels. The murder mystery because it has all the elements: the crime takes place in a sealed room. In this instance, sealed not only because it occurred in a house, but also in a country, a sealed place of privilege. The victim was a society lady. Burglary is not the motive. In classic murder mystery novels, it was a bit unseemly that one should kill in order to rob. One killed either for a juicy sum of money, or for revenge, or out of passion. In those novels there were neither corrupt judges nor fugitive lawyers. Once Sherlock Holmes […] or Hercule Poirot […] said ‘this is the murderer’, that was that. That’s to say, once fingered in the climactic living room scene, with everyone gathered around the hearth, the perpetrator wouldn’t resist at all. And everyone would be happy because the judges were thought to be upright persons, at least in fiction. […] The violence of the crime of María Marta is part of the hard-boiled novel, and the sealed location in which it takes place, part of the murder mystery (Alarcón). I’ve argued elsewhere (Munro, Belsunce) that the translation of the case to the genres of crime fiction and their metaanalysis was a means by which a victimised Argentine public, represented by a disempowered and marginalised fourth estate, sought some rhetorical recompense. The postulate of resilience, however, might help further to describe and contextualise this notorious discursive event. A disaffected Argentine press finds itself in a stability domain with multiple attractors: on the one hand, an acquiescence to ever-increasing politico-juridical corruption, malfeasance and elitist impunity; on the other, an attractor of increasing contestation, democratisation, accountability and transparency. A discursive event like the caso Belsunce further perturbs Argentine society, threatening to displace it from its democratising trajectory. Unable to enforce due process, Argentina’s fourth estate adapts, doing what, in the circumstances, amounts to the next best thing: it denounces the proceedings by translating the case to the genres of crime fiction. In so doing, it engages a venerable reception history in which the co-constitution of true crime fiction and investigative journalism is exemplified by the figure of Rodolfo Walsh, whose denunciatory works mark a “politicisation of crime” (see Amar Sánchez Juegos; El sueño). Put otherwise, a section of Argentina’s fourth estate bounced back: by making poetics do rhetorical work, it resisted the pull towards what ecology calls an undesirable basin of attraction. Through a show of discursive resilience, these journalists worked to keep Argentine society on a democratising track. 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Introduction As the country with the fifth largest population in the world, Indonesia is a massive potential market for mobile technology adoption and development. Despite an annual per capita income of only $1,280 USD (World Bank), there are 63 million mobile phone users in Indonesia (Suhartono, sec. 1.7) and it is predicted to reach 80 million in 2007 (Jakarta Post 1). Mobile phones are not only a symbol of Indonesian modernity (Barendregt 5), but like other communication technology can become a platform through which to explore socio-political issues (Winner 28). In this article we explore the role mobile phone technology in contemporary forms of social, intimate, and sexual relationships in Indonesia. We argue that new forms of expression and relations are facilitated by the particular features of mobile technology. We discuss two cases from contemporary Indonesia: a mobile dating service (BEDD) and mobile phone pornography. For each case study, we first discuss the socio-political background in Indonesia, then describe the technological affordances of the mobile phone which facilitate dating and pornography, and finally give examples of how the mobile phone is effecting change in dating and pornographic practices. This study is placed at a time when social relations, intimacy, and sexuality in Indonesia have become central public issues. Since the end of the New Order whilst many people have embraced the new freedoms of reformasi and democratization, there is also a high degree of social anxiety, tension and uncertainty (Juliastuti 139-40). These social changes and desires have played out in the formations of new and exciting modes of creativity, solidarity, and sociality (Heryanto and Hadiz 262) and equally violence, terror and criminality (Heryanto and Hadiz 256). The diverse and plural nature of Indonesian society is alive with a myriad of people and activities, and it is into this diverse social body that the mobile phone has become a central and prominent feature of interaction. The focus of our study is dating and pornography as mediated by the mobile phone; however, we do not suggest that these are new experiences in Indonesia. Rather over the last decade social, intimate, and sexual relationships have all been undergoing change and their motivations can be traced to a variety of sources including the factors of globalization, democratization and modernization. Throughout Asia “new media have become a crucial site for constituting new Asian sexual identities and communities” (Berry, Martin, and Yue 13) as people are connecting through new communication technologies. In this article we suggest that mobile phone technology opens new possibilities and introduces new channels, dynamics, and intensities of social interaction. Mobile phones are particularly powerful communication tools because of their mobility, accessibility, and convergence (Ling 16-19; Ito 14-15; Katz and Aakhus 303). These characteristics of mobile phones do not in and of themselves bring about any particular changes in dating and pornography, but they may facilitate changes already underway (Barendegt 7-9; Barker 9). Mobile Dating Background The majority of Indonesians in the 1960s and 1970s had arranged marriages (Smith-Hefner 443). Education reform during the 70s and 80s encouraged more women to attain an education which in turn led to the delaying of marriage and the changing of courtship practices (Smith-Hefner 450). “Compared to previous generations, [younger Indonesians] are freer to mix with the opposite sex and to choose their own marriage,” (Utomo 225). Modern courtship in Java is characterized by “self-initiated romance” and dating (Smith-Hefner 451). Mobile technology is beginning to play a role in initiating romance between young Indonesians. Technology One mobile matching or dating service available in Indonesia is called BEDD (www.bedd.com). BEDD is a free software for mobile phones in which users fill out a profile about themselves and can meet BEDD members who are within 20-30 feet using a Bluetooth connection on their mobile devices. BEDD members’ phones automatically exchange profile information so that users can easily meet new people who match their profile requests. BEDD calls itself mobile social networking community; “BEDD is a new Bluetooth enabled mobile social medium that allows people to meet, interact and communicate in a new way by letting their mobile phones do all the work as they go throughout their day.” As part of a larger project on mobile social networking (Humphreys 6), a field study was conducted of BEDD users in Jakarta, Indonesia and Singapore (where BEDD is based) in early 2006. In-depth interviews and open-ended user surveys were conducted with users, BEDD’s CEO and strategic partners in order to understand the social uses and effects BEDD. The majority of BEDD members (which topped 100,000 in January 2006) are in Indonesia thanks to a partnership with Nokia where BEDD came pre-installed on several phone models. In management interviews, both BEDD and Nokia explained that they partnered because both companies want to help “build community”. They felt that Bluetooth technology such as BEDD could be used to help youth meet new people and keep in touch with old friends. Examples One of BEDD’s functions is to help lower barriers to social interaction in public spaces. By sharing profile information and allowing for free text messaging, BEDD can facilitate conversations between BEDD members. According to users, mediating the initial conversation also helps to alleviate social anxiety, which often accompanies meeting new people. While social mingling and hanging out between Jakarta teenagers is a relatively common practice, one user said that BEDD provides a new and fun way to meet and flirt. In a society that must balance between an “idealized morality” and an increasingly sexualized popular culture (Utomo 226), BEDD provides a modern mode of self-initiated matchmaking. While BEDD was originally intended to aid in the matchmaking process of dating, it has been appropriated into everyday life in Indonesia because of its interpretive flexibility (Pinch & Bjiker 27). Though BEDD is certainly used to meet “beautiful girls” (according to one Indonesian male user), it is also commonly used to text message old friends. One member said he uses BEDD to text his friends in class when the lecture gets boring. BEDD appears to be a helpful modern communication tool when people are physically proximate but cannot easily talk to one another. BEDD can become a covert way to exchange messages with people nearby for free. Another potential explanation for BEDD’s increasing popularity is its ability to allow users to have private conversations in public space. Bennett notes that courtship in private spaces is seen as dangerous because it may lead to sexual impropriety (154). Dating and courtship in public spaces are seen as safer, particularly for conserving the reputation young Indonesian women. Therefore Bluetooth connections via mobile technologies can be a tool to make private social connections between young men and women “safer”. Bluetooth communication via mobile phones has also become prevalent in more conservative Muslim societies (Sullivan, par. 7; Braude, par. 3). There are, however, safety concerns about meeting strangers in public spaces. When asked, “What advice would you give a first time BEDD user?” one respondent answered, “harus bisa mnilai seseorang krn itu sangat penting, kita mnilai seseorang bukan cuma dari luarnya” (translated: be careful in evaluating (new) people, and don’t ever judge the book by its cover”). Nevertheless, only one person participating in this study mentioned this concern. To some degree meeting someone in a public may be safer than meeting someone in an online environment. Not only are there other people around in public spaces to physically observe, but co-location means there may be some accountability for how BEDD members present themselves. The development and adoption of matchmaking services such as BEDD suggests that the role of the mobile phone in Indonesia is not just to communicate with friends and family but to act as a modern social networking tool as well. For young Indonesians BEDD can facilitate the transfer of social information so as to encourage the development of new social ties. That said, there is still debate about exactly whom BEDD is connecting and for what purposes. On one hand, BEDD could help build community in Indonesia. One the other hand, because of its privacy it could become a tool for more promiscuous activities (Bennett 154-5). There are user profiles to suggest that people are using BEDD for both purposes. For example, note what four young women in Jakarta wrote in the BEDD profiles: Personal Description Looking For I am a good prayer, recite the holy book, love saving (money), love cycling… and a bit narcist. Meaning of life Ordinary gurl, good student, single, Owen lover, and the rest is up to you to judge. Phrenz ?! Peace?! Wondeful life! I am talkative, have no patience but so sweet. I am so girly, narcist, shy and love cute guys. Check my fs (Friendster) account if you’re so curious. Well, I am just an ordinary girl tho. Anybody who wants to know me. A boy friend would be welcomed. Play Station addict—can’t live without it! I am a rebel, love rock, love hiphop, naughty, if you want proof dial 081********* phrenz n cute guyz As these profiles suggest, the technology can be used to send different kinds of messages. The mobile phone and the BEDD software merely facilitate the process of social exchange, but what Indonesians use it for is up to them. Thus BEDD and the mobile phone become tools through which Indonesians can explore their identities. BEDD can be used in a variety of social and communicative contexts to allow users to explore their modern, social freedoms. Mobile Pornography Background Mobile phone pornography builds on a long tradition of pornography and sexually explicit material in Indonesia through the use of a new technology for an old art and product. Indonesia has a rich sexual history with a documented and prevalent sex industry (Suryakusuma 115). Lesmana suggests that the country has a tenuous pornographic industry prone to censorship and nationalist politics intent on its destruction. Since the end of the New Order and opening of press freedoms there has been a proliferation in published material including a mushrooming of tabloids, men’s magazines such as FHM, Maxim and Playboy, which are often regarded as pornographic. This is attributed to the decline of the power of the bureaucracy and government and the new role of capital in the formation of culture (Chua 16). There is a parallel pornography industry, however, that is more amateur, local, and homemade (Barker 6). It is into this range of material that mobile phone pornography falls. Amongst the myriad forms of pornography and sexually explicit material available in Indonesia, the mobile phone in recent years has emerged as a new platform for production, distribution, and consumption. This section will not deal with the ethics of representation nor engage with the debate about definitions and the rights and wrongs of pornography. Instead what will be shown is how the mobile phone can be and has been used as an instrument/medium for the production and consumption of pornography within contemporary social relationships. Technology There are several technological features of the mobile phone that make pornography possible. As has already been noted the mobile phone has had a large adoption rate in Indonesia, and increasingly these phones come equipped with cameras and the ability to send data via MMS and Bluetooth. Coupled with the mobility of the phone, the convergence of technology in the mobile phone makes it possible for pornography to be produced and consumed in a different way than what has been possible before. It is only recently that the mobile phone has been marketed as a video camera with the release of the Nokia N90; however, quality and recording time are severely limited. Still, the mobile phone is a convenient and at-hand tool for the production and consumption of individually made, local, and non-professional pieces of porn, sex and sexuality. It is impossible to know how many such films are in circulation. A number of websites that offer these films for downloads host between 50 and 100 clips in .3gp file format, with probably more in actual circulation. At the very least, this is a tenfold increase in number compared to the recent emergence of non-professional VCD films (Barker 3). This must in part be attributed to the advantages that the mobile phone has over standard video cameras including cost, mobility, convergence, and the absence of intervening data processing and disc production. Examples There are various examples of mobile pornography in Indonesia. These range from the pornographic text message sent between lovers to the mobile phone video of explicit sexual acts (Barendregt 14-5). The mobile phone affords privacy for the production and exchange of pornographic messages and media. Because mobile devices are individually owned, however, pornographic material found on mobile phones can be directly tied to the individual owners. For example, police in Kotabaru inspected the phones of high school students in search of pornographic materials and arrested those individuals on whose phones it was found (Barendregt 18). Mobile phone pornography became a national political issue in 2006 when an explicit one-minute clip of a singer and an Indonesian politician became public. Videoed in 2004, the clip shows Maria Eva, a 27 year-old dangdut singer (see Browne, 25-6) and Yahya Zaini, a married 42 year-old who was head of religious affairs for the Golkar political party. Their three-year affair ended in 2005, but the film did not become public until 2006. It spread like wildfire between phones and across the internet, however, and put an otherwise secret relationship into the limelight. These types of affairs and relationships were common knowledge to people through gossip, exposes such as Jakarta Undercover (Emka 93-108) and stories in tabloids; yet this culture of adultery and prostitution continued and remained anonymous because of bureaucratic control of evidence and information (Suryakusuma 115). In this case, however, the filming of Maria Eva once public proves the identities of those involved and their infidelity. As a result of the scandal it was further revealed that Maria Eva had been forced by Yayha Zaini and his wife to have an abortion, deepening the moral crisis. Yahya Zaini later resigned as his party’s head of Religious Affairs (Asmarani, sec. 1-2), due to what was called the country’s “first real sex scandal” (Naughton, par. 2). As these examples show, there are definite risks and consequences involved in the production of mobile pornography. Even messages/media that are meant to be shared between two consenting individuals can eventually make their way into the public mobile realm and have serious consequences for those involved. Mobile video and photography does, however, represent a potential new check on the Indonesian bureaucratic elite which has not been previously available by other means such as a watchdog media. “The role of the press as a control mechanism is practically nonexistent [in Jakarta], which in effect protects corruption, nepotism, financial manipulation, social injustice, and repression, as well as the murky sexual life of the bureaucratic power elite,” (Suryakusuma 117). Thus while originally a mobile video may have been created for personal pleasure, through its mass dissemination via new media it can become a means of sousveillance (Mann, Nolan and Wellman 332-3) whereby the control of surveillance is flipped to reveal the often hidden abuses of power by officials. Whilst the debates over pornography in Indonesia tend to focus on the moral aspects of it, the broader social impacts of technology on relationships are often ignored. Issues related to power relations or even media as cultural expression are often disregarded as moral judgments cast a heavy shadow over discussions of locally produced Indonesian mobile pornography. It is possible to move beyond the moral critique of pornographic media to explore the social significance of its proliferation as a cultural product. Conclusion In these two case studies we have tried to show how the mobile phone in Indonesia has become a mode of interaction but also a platform through which to explore other current issues and debates related to dating, sexuality and media. Since 1998 and the fall of the New Order, Indonesia has been struggling with blending old and new, a desire of change and nostalgia for past, and popular desire for a “New Indonesia” (Heryanto, sec. Post-1998). Cultural products within Indonesia have played an important role in exploring these issues. The mobile phone in Indonesia is not just a technology, but also a product in and through which these desires are played out. Changes in dating and pornography practices have been occurring in Indonesia for some time. As people use mobile technology to produce, communicate, and consume, the device becomes intricately related to identity struggle and cultural production within Indonesia. It is important to keep in mind, however, that while mobile technology adoption within Indonesia is growing, it is still limited to a particular subset of the population. As has been previously observed (Barendregt 3), it is wealthier, young people in urban areas who are most intensely involved in mobile technology. As handset prices decrease and availability in rural areas increases, however, no longer will mobile technology be so demographically confined in Indonesia. The convergent technology of the mobile phone opens many possibilities for creative adoption and usage. As a communication device it allows for the creation, sharing, and viewing of messages. Therefore, the technology itself facilitates social connections and networking. As demonstrated in the cases of dating and pornography, the mobile phone is both a tool for meeting new people and disseminating sexual messages/media because it is a networked technology. The mobile phone is not fundamentally changing dating and pornography practices, but it is accelerating social and cultural trends already underway in Indonesia by facilitating the exchange and dissemination of messages and media. As these case studies show, what kinds of messages Indonesians choose to create and share are up to them. The same device can be used for relatively innocuous behavior as well as more controversial behavior. With increased adoption in Indonesia, the mobile will continue to be a lens through which to further explore modern socio-political issues. 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"Modernity and the Mobile Phone: Exploring Tensions about Dating and Sex in Indonesia." M/C Journal 10.1 (2007). echo date('d M. Y'); ?> <http://journal.media-culture.org.au/0703/06-humphreys-barker.php>. APA Style Humphreys, L., and T. Barker. (Mar. 2007) "Modernity and the Mobile Phone: Exploring Tensions about Dating and Sex in Indonesia," M/C Journal, 10(1). Retrieved echo date('d M. Y'); ?> from <http://journal.media-culture.org.au/0703/06-humphreys-barker.php>.

Il presente elaborato riporta una misura della massa del quark top effettuata impiegando dati raccolti tramite il rivelatore CMS a LHC durante il Run del 2016, con energia del centro di massa per le collisioni pp pari a 13 TeV e luminosità integrata di 37.0 fb^(−1). Sono stati studiati i prodotti di decadimento di coppie tt secondo il canale totalmente adronico (all jets) in regime boosted. Tale canale risulta essere caratterizzato dalla presenza di due jet ampi, associati sia al decadimento dei bosoni W che al quark b. Per migliorare la purezza del campione gli eventi candidati sono stati selezionati richiedendo la presenza di quark b in ciascuno di essi. Un'ulteriore richiesta di selezione è stata imposta tramite un'analisi multivariata per aumentare la discriminazione degli eventi di fondo. La misura della massa del quark top è stata ottenuta effettuando un fit di massima verosimiglianza e considerando possibili cause di incertezza sistematica. Il valore finale risulta essere: m_t = 171.9 ± 0.3(stat) ± 1.7(sist) GeV. La misura risulta pertanto consistente con la media mondiale di 173.1 ± 0.6 GeV.

In questa tesi ci concentriamo su alcuni aspetti teorici che concernono la determinazione della massa del quark top ($ m_t $), problema che persiste nell'essere altamente controverso. Generalmente, per misurare la massa del top, sono necessarie predizioni teoriche dipendenti da $m_t$. Il parametro $m_t$ coincide con la massa fisica, che è collegata alla massa nuda attraverso una procedura di rinormalizzazione. Sono possibili diversi schemi di rinormalizzazione per la massa e il più naturale sembra essere quello della massa polo. Tuttavia, nel caso di oggetti colorati, la massa polo contiene rinormaloni di origine infrarossa, i quali si manifestano come coefficienti che crescono fattorialmente, rovinando la convergenza delle serie perturbativa e portando ad ambigutá di ordine $\Lambda_{\rm QCD}$. D’altro canto, shemi di massa come l’$\overline{\rm MS}$ sono liberi da questi rinormaloni. Fortunatamente, l’ambiguitá rinormalonica sembra essere ben al di sotto dell’errore sistematico quotato per le misurazioni della massa polo. Pertanto questo tipo di determinazione è ancora affidabile. Nella prima parte della tesi studiamo la presenza di rinormaloni in osservabili che possono essere impiegate per la determinazione della massa del top. Consideriamo un modello semplificato per descrivere il processo $W^* \to t \bar{b} \to W b \bar{b}$. Il calcolo è eseguito nel limite in cui il numero di sapori dei quark leggeri $n_f$ è molto grande, utilizzando un nuovo metodo con cui è possibile valutare numericamente una generica osservabile all’ordine $\alpha_s(\alpha_s n_f)^n$ per ogni valore di $n$. Due sono le sorgenti di rinormaloni nelle nostre osservabile: l’uso della massa polo e la richiesta di tagli cinematici sui momenti dei jet. Per questo, predizioni ottenute nello schema polo sono comparate con quelle calcolate nello schema $\overline{\rm MS}$. Dalla nostra analisi risulta che la sezione d’urto senza tagli, se espressa in termini della massa $\overline{\rm MS}$, è libera da rinormaloni lineari, i quali appaiono però in ogni schema appena vengono introdotti dei tagli cinematici relativi al momento dei jet. Inoltre, la massa dei prodotti di decadimento del top è sempre affetta da rinormaloni lineari. L’energia del bosone $W$ ha un rinormalone in ogni schema nel limite in cui la larghezza di decadimento del top è zero, altrimenti, quando una larghezza finita è usata nel calcolo, tali rinormaloni sono assenti nello schema $\overline{\rm MS}$. Le determinazioni più precise della massa del top sono quelle dirette, ossia quelle basate sulla ricostruzione della cinematica dei prodotti di decadimento del top. Queste misure sono basate sull’uso di generatori di eventi Monte Carlo. I generatori che vengono utilizzati devono essere il più accurati possibili, onde evitare imprecisioni nella misura. A questo proposito, nella seconda parte della tesi confrontiamo diversi generatori NLO, implementati nel codice {\tt POWHEG BOX}, che differiscono per il livello di accuratezza impiegato nel descrivere il decadimento del top. Anche l’impatto dei programmi Monte Carlo che implementano la “parton shower”, e che quindi completano gli eventi generati da POWHEG BOX, è oggetto di studio in questa seconda parte della tesi. In particolare, noi ci focalizziamo sui programmi più usati, Pythia8.2 ed Herwig7.1, e presentiamo un metodo per interfacciarli a processi contenenti risonanze che possono emettere radiazione. Il paragone fra diversi generatori Monte Carlo che hanno formalmente lo stesso livello di accuratezza è infatti un passo obbligato verso una stima ragionevole dell’incertezza associata alla misurazione della massa del quark top.
In this thesis we focus on the theoretical subtleties of the top-quark mass ($m_t$) determination, issue which persists in being highly controversial. Typically, in order to infer the top mass, theoretical predictions dependent on $m_t$ are employed. The parameter $m_t$ is the physical mass, that is connected with the bare mass though a renormalization procedure. Several renormalization schemes are possible and the most natural seems to be the pole-mass one. However, the pole mass is not very well defined for a coloured object like the top quark. The pole mass is indeed affected by the presence of infrared renormalons. They manifest as factorially growing coefficients that spoil the convergence of the perturbative series, leading to ambiguities of order of $\Lambda_{\rm QCD}$. On the other hand, short-distance mass schemes, like the $\overline{\rm MS}$, are known to be free from such renormalons. Luckily, the renormalon ambiguity seems to be safely below the quoted systematic errors on the pole-mass determinations, so these measurements are still valuable. In the first part of the thesis, we investigate the presence of linear renormalons in observables that can be employed to determine the top mass. We considered a simplified toy model to describe $W^* \to t \bar{b} \to Wb \bar{b}$. The computation is carried out in the limit of a large number of flavours ($n_f$), using a new method that allows to easily evaluate any infrared safe observable at order $\alpha_s(\alpha_s n_f)^n$ for any $n$. The observables we consider are, in general, affected by two sources of renormalons: the pole-mass definition and the jet requirements. We compare and discuss the predictions obtained in the usual pole scheme with those computed in the $\overline{\rm MS}$ one. We find that the total cross section without cuts, when expressed in terms of the $\overline{\rm MS}$ mass, does not exhibit linear renormalons, but, as soon as selection cuts are introduced, jets-related linear renormalons arise in any mass scheme. In addition, we show that the reconstructed mass is affected by linear renormalons in any scheme. The average energy of the $W$ boson (that we consider as a simplified example of leptonic observable) has a renormalon in the narrow-width limit in any mass scheme, that is however screened at large orders for finite top widths, provided the top mass is in the $\overline{\rm MS}$ scheme. The most precise determinations of the top mass are the direct ones, i.e. those that rely upon the reconstruction of the kinematics of the top-decay products. Direct determinations are heavily based on the use of Monte Carlo event generators. The generators employed must be as much accurate as possible, in order not to introduce biases in the measurements. To this purpose, the second part of the thesis is devoted to the comparison of several NLO generators, implemented in the {\tt POWHEG BOX} framework, that differ by the level of accuracy employed to describe the top decay. The impact of the shower Monte Carlo programs, used to complete the NLO events generated by {\tt POWHEG BOX}, is also studied. In particular, we discuss the two most widely used shower Monte Carlo programs, i.e. {\tt Pythia 8.2} and \{\tt Herwig 7.1}, and we present a method to interface them with processes that contain decayed emitting resonances. The comparison of several Monte Carlo programs that have formally the same level of accuracy is, indeed, a mandatory step towards a sound estimate of the uncertainty associated with $m_t$.

Iron is essential for multiple biological functions and its plasma levels have to be tightly regulated. Hepcidin, a peptide hormone produced by liver, is the main regulator of iron homeostasis and its altered production is related to functional iron deficiency (high hepcidin levels) or iron overload (hepcidin deficiency). The first part of the project here described is the quantification of serum hepcidin levels in the Val Borbera (VB) population, a genetic isolate living in Northern Italy, as part of a larger project started in 2005 for a demographic and epidemiological analysis. Serum hepcidin measurements were performed in our lab by a validated mass spectrometry-based method i.e. Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS). This technique allowed also the discrimination and quantification of a truncated hepcidin isoform, hepcidin-20, that has been studied for the first time at population level. In the second part of the project it is described the use of the SELDI platform for proteome profiling analysis, comparing spectra of subjects affected by iron disorders with those of healthy controls. Differentially expressed peptides, representing putative novel biomarkers have been further studied, as described in the third part of the work, both by classic proteomics (co-immunoprecipitation and Western blotting) and bioinformatics approaches, in order to confirm results and gain insight about the molecular pathway involved. The results of the projects here presented, like the establishment of a reference range for hepcidin-25 levels and the discovery of a putative novel biomarker of iron homeostasis diseases, could have clinical applications, both at diagnostic and therapeutic levels.

The monograph is devoted to the literary and scientific heritage of the famous French writer, historian, philosopher, thinker, diplomat and statesman F. R. de Chateaubriand, whose scientific works were practically unknown to the Russian reader for many decades. Being the founder of French romanticism and laying the main elements of this direction of culture, F. R. de Chateaubriand nevertheless causes numerous disputes and questions. The monograph shows the process of formation of the writer's romantic worldview on the example of his early works, which still retain traces of the literature of the XVIII century and already carry new romantic trends of the XIX century. The author also presents the facts of the writer's biography and analyzes a number of his historical works devoted to medieval France. From the Renaissance until the end of the XVIII century, one of the elements of medieval architecture and Christian religion-Gothic architecture — was perceived as something negative, barbaric, rude, completely inconsistent with the aesthetics of the XVI — XVIII centuries. F. R. de Chateaubriand was one of the first researchers who discovered the beauty of Gothic churches and the color of national history to the mass reader at the turn of the XVIII—XIX centuries. The rehabilitation of Gothic architecture was accomplished by F. R. de Chateaubriand in his Treatise "the genius of Christianity". The famous "forest theory" of the origin of Gothic helped to "remove" negative assessments of the middle Ages and influenced the formation and development of romanticism both in France and in other European countries. It was F. R. de Chateaubriand's idea of the relationship between medieval architecture and Christian consciousness that influenced all the subsequent development and formation of the history of medieval art. For a wide range of readers interested in the history of literature.

The First World War cost Europe the leadership of the world. But the United States of Woodrow Wilson was not ready to take its place. The 1920s brought Europe to a crossroads where mass democracy, mass production, and mass communications—the latter two dominated by American innovations— transformed ideas of sovereignty, modernity, and identity everywhere. The financial crash of 1929 destroyed illusions about the United States as the land of the future, and helped legitimize the totalitarians. European democrats looked to the 1930s New Deal as their last best hope. During the Second World War Roosevelt rebuilt the global order, with the United Nations and other new institutions. But the United States was now looking to ‘retire’ Europe from the world scene, and build a new universe based on America’s experience of the link between mass prosperity and democratic stability.

One of the major outstanding questions about black holes is whether they remain stable when subject to small perturbations. An affirmative answer to this question would provide strong theoretical support for the physical reality of black holes. This book takes an important step toward solving the fundamental black hole stability problem in general relativity by establishing the stability of nonrotating black holes — or Schwarzschild spacetimes — under so-called polarized perturbations. This restriction ensures that the final state of evolution is itself a Schwarzschild space. Building on the remarkable advances made in the past fifteen years in establishing quantitative linear stability, the book introduces a series of new ideas to deal with the strongly nonlinear, covariant features of the Einstein equations. Most preeminent among them is the general covariant modulation (GCM) procedure that allows them to determine the center of mass frame and the mass of the final black hole state. Essential reading for mathematicians and physicists alike, the book introduces a rich theoretical framework relevant to situations such as the full setting of the Kerr stability conjecture.

This chapter explores the role of “power politics”—the domain of national security interests and the procurement and use of military power—in the decline of mass atrocities in East Asia. It suggests that power politics made an important, but not the singularly most important, contribution. The chapter has three parts. First, it explores how conventional power politics contributed to the decline of mass atrocities in East Asia. Although not central to the overall story, once they were established, the balance of power and both conventional and nuclear deterrence played a role in limiting the further escalation of potential conflicts. Second, it examines the limits of power politics. Third, it points to specific security practices that were more consequential, including the development of omnidirectional security relations, a tendency to avoid destabilizing competition, de-polarization, and the enmeshing of great powers in the region’s norms

The previous Chapter presented a discussion of the notion of local and global equilibria and shown that these equilibria represent the special forms taken by the distribution function once direct and inverse collisions come into balance. This Chapter provides an elementary introduction to transport phenomena and discusses their intimate relation to non-equilibrium processes at the microscopic scale. In particular it shall deal with the connection between the transport coefficients, such as mass, momentum and energy diffusivity with the molecular mean free path, namely the distance traveled by a representative molecules between two subsequent collisions. The discussion also highlights the fundamental role of inhomogeneity in fueling non-equilibrium processes.

A mass of comparative material, Greek and Latin, rhythmic and unrhythmic, enables us to scrutinize sharply Plutarch’s treatment in the Life of Alexander of Alexander’s leap into an Indian city full of enemies. Alexander’s life was a field cultivated with particular assiduity by ancient writers; Plutarch himself treats the incident at length in a philosophical work: De Alexandri Magni Fortuna aut Virtute, speech 2. The density of rhythm in this passage is crucial to making the moment a climax in the Life; the writing is actually sober and intently compact when compared both to Plutarch’s own treatment in the piece mentioned and to the Homeric account in Arrian. This sobriety is historiographical as well as stylistic.

The introduction to the book discusses Saddam Hussein’s religious policies and how they eventually led to the emergence of religious insurgencies when his regime fell during the American-led invasion of Iraq in 2003. It shows that Saddam worked diligently and to some extent successfully to impose the Ba‘th Party’s Arab nationalist interpretation of religion on a critical mass of Iraqi society. The introduction also places Saddam’s policies within a broader context of authoritarian regimes in the 20th century. It discusses how these regimes needed to create the institutional capacity to deal with religion if they wanted to instrumentalize it politically. The Soviet Union created Red Priests, Communist China created the religious sector, and the Nazis created German Christians. Similarly, the Ba’thists in Iraq need to create a cadre of trusted religious leaders as well as the security infrastructure to monitor them and thus instrumentalize Islam.

The history of the evaluation of uncertain evidence before the quantification of probability in 1654 is a mass of examples relevant to current debates. They deal with matters that in general are as unquantified now as ever – the degree to which evidence supports theory, the strength and justification of inductive inferences, the weight of testimony, the combination of pieces of uncertain evidence, the price of risk, the philosophical nature of chance, and the problem of acting in case of doubt. Concepts similar to modern “proof beyond reasonable doubt” were developed especially in the legal theory of evidence. Moral theology discussed “probabilism”, the doctrine that one could follow a probable opinion in ethics even if the opposite was more probable. Philosophers understood the difficult problem of induction. Legal discussion of “aleatory contracts” such as insurance and games of chance developed the framework in which the quantification of probability eventually took place.

Carceral logics permeate our thinking about humans and nonhumans. We imagine that greater punishment will reduce crime and make society safer. We hope that more convictions and policing for animal crimes will keep animals safe and elevate their social status. The dominant approach to human-animal relations is governed by an unjust imbalance of power that subordinates or ignores the interest nonhumans have in freedom. In this volume Lori Gruen and Justin Marceau invite experts to provide insights into the complicated intersection of issues that arise in thinking about animal law, violence, mass incarceration, and social change. Advocates for enhancing the legal status of animals could learn a great deal from the history and successes (and failures) of other social movements. Likewise, social change lawyers, as well as animal advocates, might learn lessons from each other about the interconnections of oppression as they work to achieve liberation for all. This title is also available as Open Access on Cambridge Core.

Commemoration of controversial historical episodes can trigger adverse hostile reactions of ‘decommemorating’, which aim to stamp out memory but in practice signify an oblique form of engaging with remembrance. In the wider context of a fin-de-siècle craze for commemoration, the centenary of the 1798 rebellion was celebrated by nationalists in Ulster in 1898. The commemorations were contested on many levels, showing infighting between rival nationalist factions, as well as conflicts between nationalists and unionists. Overt displays of public remembrance antagonized loyalists, provoking mass rioting and the destruction of a monument for a folk heroine. In turn, renewed interest among cultural revivalists resulted in new productions of cultural memory. Decommemorating triggered a surge of re-commemorating, which came to an end with the outbreak of the Irish Revolution.

Tanzania Peace Corps director Paul Sack and Peace Corps doctor Tom McHugh fly to Mwanza, meet with attorneys, then fly to Maswa. In Maswa, they meet Bill, who appears to be suffering from a severe stress reaction; McHugh performs a postmortem on Peppy; and they fly back to Mwanza, where McHugh assists an eminent pathologist from Nairobi in a second and more complete autopsy. In Dar es Salaam, Peace Corps officials meet with Tanzania police officers to find out how the police plan to proceed, while Peace Corps medical staff deal with the complex issues of obtaining a coffin suitable for withstanding the heat and humidity, the proper medical exit authorization, and where to find an expert pathologist.

The robotic neck mechanism considered in this paper has as main element a soft link that emulates a human neck with two DOF (flexion, extension and lateral bending). The mechanism is based on a Cable-Driven Parallel Mechanism (CDPM) with components easy to manufacture in a 3D printer.Due to the soft link properties and the platform mechanics, it is important to provide a robust control system. Two designs, a robust PID controller and a Fractional Order PI controller (FOPI) are proposed and compared, the fractional order control showing an enhanced performance. Both control approaches are tested in the real prototype, validating the soft neck feasibility and showing the robustness of the platform to mass changes at the neck tip.

This chapter focuses on the relationship between race and space—between competing ideas for how people of different races should reside spatially—by looking at the Union army’s various attempts to remove refugees en masse. These removals attempted to resettle the people in places far removed from active combat, including northern states, islands in the Mississippi River, and even Haiti. Some of these efforts bore a great deal of resemblance to antebellum colonization plans, and, as in those cases, black men and women in the Civil War largely resisted being sent away. Most of the removals were justified by white officials in environmental terms, driven by racial ideologies that linked particular climates and landscapes to people of color. The chapter also argues that removals were sometimes triggered by concerns about gender and sex too—by beliefs that the physical proximity of black women and white men in military encampments had made rape inevitable.

In this work, DEP platforms with funnelled and micro-tip electrode patterns were fabricated, and integrated with polydimethylsiloxane (PDMS) microchannel blocks. The DEP platforms were employed to manipulate polystyrene particles of 1 and 3 μm. The response of the system was characterised in a wide range of signal magnitudes (1–30 V peak-to-peak) and frequencies (100 kHz to 200 MHz), as well as the liquid flow rates (1 to 10 μL/min). Calculations were also carried out to analyse the DEP spectra of polystyrene particles when suspended in the medium (deionised water) to determine the optimum operating frequency of the DEP systems. Both experimental results and theoretical calculations indicated that polystyrene particles can experience positive and negative DEP forces within certain frequency ranges of the applied electric field, and the crossover frequency (where the DEP force is zero) of the system strongly depends on the conductivities of the particles. Additionally, larger particles experience stronger DEP forces and can be more efficiently concentrated at or repelled along the electrodes. The concentration performance of the DEP systems were evaluated by measuring the thickness of particle streams at different flow rates. Finally, the ability of funnelled and micro-tip electrodes to trap the particles was compared.

Abstract Numerical investigations have been performed to study the effect of incidence angle on the aerodynamic and film cooling performance for the suction surface squealer tip with different film-hole arrangements at τ = 1.5% and BR = 1.0. Meanwhile, the full squealer tip as baseline is also investigated. Three incidence angles at design condition (0 deg) and off-design conditions (± 7 deg) are investigated. The suction surface, pressure surface, and the camber line have seven holes each, with an extra hole right at the leading edge. The Mach number at the cascade inlet and outlet are 0.24 and 0.52, respectively. The results show that the incidence angle has a significant effect on the tip leakage flow characteristics and coolant flow direction. The film cooling effectiveness distribution is altered, especially for the film holes near the leading edge. When the incidence angle changes from +7 deg to 0 and −7 deg, the ‘re-attachment line’ moves downstream and the total tip leakage mass flow ratio decreases, but the suction surface tip leakage mass flow ratio near leading edge increases. In general, the total tip leakage mass flow ratio for suction surface squealer tip is 1% greater than that for full squealer tip at the same incidence angle. The total pressure loss coefficient of suction surface squealer tip is larger than that for full squealer tip. The full squealer tip with film holes near suction surface and the suction surface squealer tip with film hole along camber line show high film cooling performance, and the area averaged film cooling effectiveness at positive incidence angle +7 deg is higher than that at 0 and −7 deg. The coolant discharged from film holes near pressure surface only cools narrow region near pressure surface.

Micro-electro mechanical systems (MEMS) biochips realizing high-speed and high-efficiency of reaction and analysis attract much attention in medical as well as chemical fields. Especially, the miniaturized devices enabling small sample volume, arrayed, and portable measurement may become a powerful tool for material analysis and process control. We have proposed a novel micro optical diffusion sensor (MODS) which enables small sample volume, highspeed and non-contact measurement of diffusion coefficient of liquid sample. MODS consists of a pair of transparent electrodes (Al-doped Zinc oxide: AZO), a photoconductive layer (amorphous silicon: a-Si:H), two MEMS mirrors and excitation and probing fibers for inducing and detecting concentration distribution. The initial concentration distribution of sample is created by an opto-dielectrophoretic (opto-DEP) manipulation along with a sinusoidal pattern of irradiated beam on a photoconductive layer. In the present paper, the measurement principle is proposed, and the preliminary experiment using a bench top apparatus is reported.

Forests comprised of nominally vertically aligned carbon nanotubes (CNTs), having outstanding thermal and mechanical properties, are excellent candidates for thermal interface materials (TIMs). However, the thermal performance of CNT forest TIMs has been limited by the presence of high thermal contact resistances at the CNT tip interface. The high thermal contact resistance at the CNT tip interface stems from two sources: (1) the relatively weak van der Waals type bonding, which impedes phonon transport, and (2) low contact area. In this work we will show that common solvents, such as water, can be applied to the CNT forest to increase the contact area and reduce the contact resistance by an average of 75%. Specifically, there are two likely mechanisms that can increase the contact area when a CNT forest is wet with a fluid and compressed in an interface. The first is relaxing the van der Waals interactions between contacting CNTs within the forest, consequently decreasing the stiffness of the forest and allowing it to better conform to the opposing surface. The second is the pulling of CNT tips through capillary interactions into contact with the opposing surface as the solvent evaporates. By measuring the thermal resistance of CNT TIMs before and after soaking in variety of solvents the capacity of each mechanism for reducing the contact resistance is explored.

El cambio climático exige que las ciudades introduzcan la sostenibilidad ambiental en su renovación, el concepto de Desarrollo Orientado al Transporte Sostenible –DOTS- ha venido estudiando la integración de los sistemas de transporte al urbanismo, por esta razón este artículo estudia, en ese sentido, específicamente la influencia que tiene la localización de los usos en la ciudad como elemento que propicia o evita las emisiones contaminantes por causa del transporte a partir de la revisión de los datos más recientes de movilidad en Bogotá en cuanto a modos utilizados, motivos de los viajes, localización del origen y destino, tiempos de viaje y el espacio público entorno a los sistemas de transporte; con el fin de identificar los elementos del DOTS en Bogotá, en relación con usos del suelo, la relación entre la infraestructura masiva y no motorizada y la articulación de con los instrumentos de planeación urbana existentes. Climate change requires that cities introduce environmental sustainability in its renewal, the concept of Transport Oriented Development -TOD- has been studing the integration between transport systems and urbanism, which is why this article studies, in this way, specifically the use land influence as an element that promotes or prevents emissions because of transportation from the review of the most recent mobility data in Bogotá in about modes used, reasons for travel, location of the origin and destination, travel times and public space around transport systems; to identify the TOD elements in Bogotá in relation to land use, the relationship between mass and non-motorized transport infrastructure and the join existing with urban planning instruments.

Abstract The parametric response of a cantilever thick beam with a tip mass subjected to harmonic axial support motion is investigated. The governing non-linear equation of motion is derived for an arbitrary axial support motion. To formulate a simple, physically correct dynamic model for the stability and periodicity analyses, the governing equation is truncated to the first characteristic mode of vibration. Using Green’s function and Schauder’s fixed point theorem, the necessary and sufficient conditions for the existence of periodic oscillatory behavior of the beam are established. The influence of the harmonic base excitation parameters, i.e., the excitation amplitude and frequency, on the steady-state amplitude of vibration are determined. Depending on the values of the excitation amplitude and frequency in the stable and unstable regions, the solution exhibits many shapes besides the transition periodic shapes. Numerical results indicate that for a given beam under a known excitation, increasing the tip mass would usually reduce the stable periodic region. To show the effect of rotary inertia and shear deformation, the beam model is reduced to the Euler-Bernoulli and purely flexural beam theories, respectively. The results show that using purely flexural or even Euler-Bernoulli model rather than Timoshenko, would produce an incorrect periodic region.

This study deals with bio-ethanol distilled from disposed alcoholic beverages. Through the various experiments while using a small displacement engine which is equipped with electric fuel injection (E.F.I.) system, the feasibility of the disposed alcoholic beverages; leftover-beer is investigated as one of the bio-mass sources. Currently bio-masses are classified into the following seven bio-mass sources, livestock excreta, sewage sludge, human waste sludge, waste of food, agricultural residue, wood-based (wood chips) bio-mass and crops. In those bio-mass sources, the authors pay their attention to the amount of leftover-beer after a banquet. Our investigation clarifies that about 12 l of beer is left and disposed after a banquet of 150 people. Since beer contains 5% alcohols, 600 cc of ethanol can be obtained without fermentation process. Thus in order to obtain alcohol as a fuel, in collaboration with some hotels, leftover-beer is collected. As to a fuel, higher concentration of distilled alcoholic beverages is preferable. Therefore a new double distillation system is developed to separate water, and 85.9% bio-ethanol fuel is produced from 5% alcoholic density of leftover-beer. The ethanol evaporation characteristic of this bio-ethanol is investigated, it is equal to 98% ethanol reagent. This showed that it can be mixed with gasoline. Also, in order to confirm its performance as a fuel, the obtained ethanol is experimented with 121 cc of small displacement engine which is equipped with E.F.I. system. The results of this experiment are compared to unleaded gasoline and showed that it has the same performance of engine power, especially in case of before top dead center (B.T.D.C.) 15.0 deg.. We also calculated the volume of CO2 emission discharged in distilled ethanol under driving conditions B.T.D.C. 15.0 deg., 4000 rpm, for 1 hour. The CO2 production of distilled ethanol is 34.4 kgCO2, on the other hand, CO2 production of unleaded gasoline is 2.82 kgCO2. This result shows that the system with high energy efficiency to separate ethanol and water is desired. Furthermore, the density of acetaldehyde from exhaust gas is analyzed. An extremely low reading of 28 ppm is obtained. The results prove the effect of acetaldehyde to the human body is negligible. Finally, employing 50 cc motorcycles with our developed E.F.I. system, experiment with bio-mass ethanol is executed. The results proved the feasibility of our developed bio-ethanol can be a new low emission bio-mass source.

High thermal load on the turbine blade tip surface would lead to high temperature corrosion and severe structural damage. One method to reduce blade tip high thermal stress is to use cooler fluid from the compressor, that exists dirt purge hole mounted on the tip underside, for cooling purpose. In this study, internal serpentine cooling passage is modeled as a U bend channel with a sharp 180-deg turn with the dirt purge hole arranged at the tip-wall. The effect of the layout of dirt purge hole and varying coolant mass flow rate on flow structure, heat transfer on the tip-wall and friction factor of the U bend channel are numerically studied with Reynolds number ranging from 100,000 to 440,000. The results show that the vortex pair is forced to flow near the tip-wall while the increasing shearing effect induced by the vortex pairs increases the local heat transfer. With an increase mass flow rate of the dirt purge hole, the suction effect enhances the local heat transfer performance. However, the pressure loss is also increased accordingly at all Reynolds numbers. The augmentations with Reynold analogy performance and the thermal performance for 5.8% mass flow rate case is 12.5% and 12.7%, respectively, which reaches the highest performance augmentation compared to the smooth-tip channel.

Though the solid-gas multiphase flow has been studied experimentally and numerically, the transport phenomena have not been cleared due to its complexity, computational time required and economical costs for hardwares. In this study the heat and mass transfer of solid-gas collision dominated flow in a rectangular vessel is analyzed by the Discrete Particle Simulation (DPS), a kind of the Dispersed Element Methods (DEM)[1]. This method describes the discrete phase and continuous phase by the Lagrange and the Euler methods respectively, and has been used to simulate the multiphase flows of various geometrical systems. In order to analyze the thermal field we took account of the energy equation and heat conduction between colliding particles. We treated the continuous phase as a pseudo two dimensional flow, and the interaction between continuous and discrete phases as two way coupling. The positions, the momenta and the temperature information of particles and velocity and temperature distribution of fluid were obtained as functions of time from results of these numerical simulations. When the hot air flowed from bottom to top in the vessel of packed bed, we traced the particles and got the temperature distribution of fluid. The particles at the surface of the packed bed jumped first and made the void areas at the middle of vessel. We found the void areas that rise in the dispersed particles.

La poesía gráfica se ha consolidado en los últimos años como uno de los campos de experimentación del cómic más activo y fructífero. La exploración de las posibilidades del cómic alejadas de la tradicional narratividad secuencial ha permitido entroncar la narración visual con la poesía concreta y caligramática, encontrando una relación cuya naturalidad y potencialidad resulta sorprendente (McHale, 2010). Aunque las primeras experiencias de la poesía gráfica pueden ser rastreadas en la obra de George Herriman y en la fundacional Poema en viñetas de Dino Buzzatti, en la última década se ha producido un desarrollo espectacular desde el espacio de libertad que representa la autoedición y el fanzinismo. Autores y autoras como Bianca Stone, Warren Craghead o Tom Hart han marcado un camino que en España ha sido seguido por una activa generación de jóvenes autores y autoras entre los que destacan Cynthia Alfonso, Klari Moreno, Julia Huete, María Medem, Óscar Raña, Begoña García-Alén, Andrés Magan o Roberto Masso, entre otros. En este trabajo, analizaremos la obra de García-Alén (Pontevedra, 1989), estudiando la evolución que se ha producido desde sus primeras publicaciones autoeditadas en su sello Noche Liquida, como Lujo Infinito (2015), La máscara de oro (2016), Orden y Forma (2016), Unha Gran Dama (2017) y Nueva Mística de Vigo (2018), a las publicadas por editoriales alternativas, como Perlas del Infierno (Fosfatina, 2014) o Nuevas estructuras (Apa Apa Cómics, 2017). Nos centraremos especialmente es esta última, examinando sus estrategias de narración visual a través del simbolismo, la composición espacial y cromática y el montaje analítico como estructura temporal interna de la página. McHale, B. (2010) Narrativity and Segmentivity, or, Poetry in the Gutter. En M. Grishakova y M.L Ryan (eds.), Intermediality and Storytelling, (p 27-48). Berlin: Walter de Gruyter.

The Joint Comprehensive Plan of Action (JCPOA) explicitly states that it “should not be considered as setting precedents for any other state or for fundamental principles of international law.” However, its unique negotiations process, provisions, and implementation created an important set of tools that could provide valuable insights and lessons for a Middle East Weapons of mass Destruction Free Zone (ME WMDFZ). Understanding these tools in a regional context based on the JCPOA experience could provide ME WMDFZ negotiators and researchers important additional tools, ideas, and lessons learned on the road toward negotiating a Zone treaty. This series explores lessons from the JCPOA for the ME WMDFZ through essays focusing on five key themes, including the Iran nuclear deal’s negotiating process, structure and format; nuclear fuel cycle activities and research; safeguards and verification; nuclear cooperation; and compliance and enforcement.

One of the main functions of mass media is influence on public opinion. So emotionally-painted lexical means are widely used in mass media in relation to leading politicians who are the centre of political arena. They are exposed to the frequent criticism, a negative estimation. The present article is devoted to the consideration of pejorative lexicon which is applied in nominations for heads of states. An empirical material of research were electronic newspapers and editions: Der Spiegel, Die Zeit, Sueddeutsche Zeitung, Der Tagesspiegel, taz, Die Welt, Gegenblende. As the basic methods of research are the following: the componental analysis, the lexico-semantic analysis, the stylistic analysis. The result of research revealed, that in German mass media there is a significant amount of persons names pejorative colouring. They express censure, disrespect, sneer, hatred, antipathy, condemnation, mistrust and so on. There main word-formations for persons nominations are composition, a derivation with using of suffixes and subsuffixes, attributive word-combinations, metaphorically-metonymical way. The materials of the research work can be used in the course of learning German language, at the practical training in oral speech, and also in the course of lexicology, general and aspect lexicography.

Commercialization of consumers’ personal data in the digital economy poses serious, both conceptual and practical, challenges to the traditional approach of European Union (EU) Consumer Law. This article argues that mass-spread, automated, algorithmic decision-making casts doubt on the foundational paradigm of EU consumer law: consent and autonomy. Moreover, it poses threats of discrimination and under- mining of consumer privacy. It is argued that the recent legislative reaction by the EU Commission, in the form of the ‘New Deal for Consumers’, was a step in the right direction, but fell short due to its continued reliance on consent, autonomy and failure to adequately protect consumers from indirect discrimination. It is posited that a focus on creating a contracting landscape where the consumer may be properly informed in material respects is required, which in turn necessitates blending the approaches of competition, consumer protection and data protection laws.

The Report provides an overview of the current state of knowledge on the ageing of large dams –an emerging global development issue as tens of thousands of existing large dams have reached or exceeded an “alert” age threshold of 50 years, and many others will soon approach 100 years. These aged structures incur rapidly rising maintenance needs and costs while simultaneously declining their effectiveness and posing potential threats to human safety and the environment. The Report analyzes large dam construction trends across major geographical regions and primary dam functions, such as water supply, irrigation, flood control, hydropower, and recreation. Analysis of existing global datasets indicates that despite plans in some regions and countries to build more water storage dams, particularly for hydropower generation, there will not be another “dam revolution” to match the scale of the high-intensity dam construction experienced in the early to middle, 20th century. At the same time, many of the large dams constructed then are aging, and hence we are already experiencing a “mass ageing” of water storage infrastructure. The Report further explores the emerging practice of decommissioning ageing dams, which can be removal or re-operation, to address issues of ensuring public safety, escalating maintenance costs, reservoir sedimentation, and restoration of a natural river ecosystem. Decommissioning becomes the option if economic and practical limitations prevent a dam from being upgraded or if its original use has become obsolete. The cost of dam removal is estimated to be an order of magnitude less than that of repairing. The Report also gives an overview of dam decommissioning’s socio-economic impacts, including those on local livelihoods, heritage, property value, recreation, and aesthetics. Notably, the nature of these impacts varies significantly between low- and high-income countries. The Report shows that while dam decommissioning is a relatively recent phenomenon, it is gaining pace in the USA and Europe, where many dams are older. However, it is primarily small dams that have been removed to date, and the decommissioning of large dams is still in its infancy, with only a few known cases in the last decade. A few case studies of ageing and decommissioned large dams illustrate the complexity and length of the process that is often necessary to orchestrate the dam removal safely. Even removing a small dam requires years (often decades), continuous expert and public involvement, and lengthy regulatory reviews. With the mass ageing of dams well underway, it is important to develop a framework of protocols that will guide and accelerate the process of dam removal. Overall, the Report aims to attract global attention to the creeping issue of ageing water storage infrastructure and stimulate international efforts to deal with this emerging water risk. This Report’s primary target audiences are governments and their partners responsible for planning and implementing water infrastructure development and management, emphasizing adaptat

The arts do not exist in vacuum and cannot be valued in abstract ways; their value is how they make people feel, what they can empower people to do and how they interact with place to create legacy. This research presents insights across Australia and Aotearoa New Zealand about the value of arts and culture that may be factored into whole of government decision making to enable creative, vibrant, liveable and inclusive communities and nations. The COVID-19 pandemic has revealed a great deal about our societies, our collective wellbeing, and how urgent the choices we make now are for our futures. There has been a great deal of discussion – formally and informally – about the value of the arts in our lives at this time. Rightly, it has been pointed out that during this profound disruption entertainment has been a lifeline for many, and this argument serves to re-enforce what the public (and governments) already know about audience behaviours and the economic value of the arts and entertainment sectors. Wesley Enoch stated in The Saturday Paper, “[m]etrics for success are already skewing from qualitative to quantitative. In coming years, this will continue unabated, with impact measured by numbers of eyeballs engaged in transitory exposure or mass distraction rather than deep connection, community development and risk” (2020, 7). This disconnect between the impact of arts and culture on individuals and communities, and what is measured, will continue without leadership from the sector that involves more diverse voices and perspectives. In undertaking this research for Australia Council for the Arts and Manatū Taonga Ministry for Culture & Heritage, New Zealand, the agreed aims of this research are expressed as: 1. Significantly advance the understanding and approaches to design, development and implementation of assessment frameworks to gauge the value and impact of arts engagement with a focus on redefining evaluative practices to determine wellbeing, public value and social inclusion resulting from arts engagement in Australia and Aotearoa New Zealand. 2. Develop comprehensive, contemporary, rigorous new language frameworks to account for a multiplicity of understandings related to the value and impact of arts and culture across diverse communities. 3. Conduct sector analysis around understandings of markers of impact and value of arts engagement to identify success factors for broad government, policy, professional practitioner and community engagement. This research develops innovative conceptual understandings that can be used to assess the value and impact of arts and cultural engagement. The discussion shows how interaction with arts and culture creates, supports and extends factors such as public value, wellbeing, and social inclusion. The intersection of previously published research, and interviews with key informants including artists, peak arts organisations, gallery or museum staff, community cultural development organisations, funders and researchers, illuminates the differing perceptions about public value. The report proffers opportunities to develop a new discourse about what the arts contribute, how the contribution can be described, and what opportunities exist to assist the arts sector to communicate outcomes of arts engagement in Australia and Aotearoa New Zealand.

The avian influenza virus, subtype H9N2 subtype, defined as having a low pathogenicity, causes extensive economical losses in commercial flocks, probably due to management and synergism with other pathogens. AIV H9N2 was first identified in Israel in the year 2000, and since then it became endemic and widespread in Israel. Control by vaccination of commercial flocks with an inactivated vaccine has been introduced since 2007. In face of the continuous H9N2 outbreaks, and the application of the vaccination policy, we aimed in the present study to provide a method of differentiating naturally infected from vaccinated animals (DIVA). The aim of the assay would be detect only antibodies created by a de-novo infection, since the inactivated vaccine virus is not reproducing, and might provide a simple tool for mass detection of novel infections of commercial flocks. To fulfill the overall aim, the project was designed to include four operational objectives: 1. Evaluation of the genetic evolution of AIV in Israel; 2. Assessment of the diagnostic value of an NS1 ELISA; 3. NS1 ELISA as evaluation criteria for measuring the efficacy of vaccination against H9N2 AIV; 4. Development of an AIV H9 subtype specific ELISA systems. Major conclusion and implications drawn from the project were: 1. A continuous genetic change occurred in the collection of H9N2 isolates, and new introductions were identified. It was shown thatthe differences between the HA proteins of viruses used for vaccine productionand local fieldisolatesincreasedin parallelwith the durationand intensity ofvaccine use, therefore, developing a differential assay for the vaccine and the wild type viruses was the project main aim. 2. To assess the diagnostic value of an NS1 ELISA we first performed experimental infection trials using representative viruses of all introductions, and used the sera and recombinant NS1 antigens of the same viruses in homologous and heterologous NS1 ELISA combination. The NS1 ELISA was evidently reactive in all combinations, and did not discriminate significantly between different groups. 3. However, several major drawbacks of the NS1 ELISA were recognized: a) The evaluation of the vaccination effect in challenged birds, showed that the level of the NS1 antibodies dropped due to the vaccination-dependent virus level drop; b) the applicability of the NS1-ELISA was verified on sera of commercial flocks and found to be unusable due to physico-chemical composition of the sera and the recombinant antigen, c) commercial sera showed non-reactivity that might be caused by many factors, including vaccination, uncertainty regarding the infection time, and possibly low antigen avidity, d) NS1 elevated antibody levels for less than 2 months in SPF chicks. Due to the above mentioned reasons we do not recommend the application of the DIVA NS1 ELISA assay for monitoring and differentiation AIV H9N2 naturally-infected from vaccinated commercial birds.