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Articles de revues sur le sujet « LLA pediatrica »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

Tumino, Manuela, Benedetta Accordi, Manuela Sciro, et al. "Expression of Annexin 2 in Pediatric B-Acute Lymphoblastic Leukemia: A Marker of Aggressiveness and A Potential Therapeutic Target." Blood 114, no. 22 (2009): 2605. http://dx.doi.org/10.1182/blood.v114.22.2605.2605.

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Abstract Abstract 2605 Poster Board II-581 Background. Annexin II (ANXA2) is a member of a peripheral membrane-binding protein family acting in a calcium-dependent manner, is involved in many cellular mechanisms, as cell proliferation and membrane physiology and is related to cancer progression. The aim of this study was to assess the ANXA2 expression in B cell precursor acute lymphoblastic leukemia (Bcp-ALL), in the attempt to finally evaluate it as a new potential therapeutic target. Materials and Methods. The ANXA2 expression was tested in 77 newly diagnosed pediatric Bcp-ALL diagnosed and

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Gripp, Isabella Morais, Ana Luisa Fava janetti Nacari, Iris Lopes de Faria, et al. "Leucemia Linfoblástica Aguda em Pediatria: Epidemiologia, diagnóstico, terapias-alvo e desafios no tratamento." Brazilian Journal of Health Review 7, no. 9 (2024): e75785. https://doi.org/10.34119/bjhrv7n9-358.

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A leucemia linfoblástica aguda (LLA) é o câncer hematológico mais comum na infância, com uma incidência global significativa. Sua prevalência é mais alta em crianças, mas também pode ocorrer em adultos, com picos de incidência na infância e na idade adulta precoce. A doença caracteriza-se pela proliferação descontrolada de linfócitos imaturos, o que compromete a função normal da medula óssea e do sistema imunológico. O diagnóstico da LLA é realizado por meio de exames laboratoriais, como a análise do sangue periférico, mielograma e técnicas de imagem. A confirmação do diagnóstico depende da id

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dos Santos Ramos, Pâmela Camila, Yasmin Suassuna Lacerda de Vasconcelos, Lizanka Dias Abrantes, Desirée Duarte Serra, and Luciane Mari Brito Cavalcante. "Abordagem no Tratamento da Leucemia Linfoblástica Aguda em Pediatria: Monitoramento e perspectivas." Brazilian Journal of Implantology and Health Sciences 5, no. 5 (2023): 5327–41. http://dx.doi.org/10.36557/2674-8169.2023v5n5p5327-5341.

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A Leucemia Linfoblástica Aguda (LLA) em crianças é uma condição desafiadora que demanda uma abordagem terapêutica complexa e multidisciplinar. No tratamento da LLA pediátrica, o monitoramento contínuo desempenha um papel crucial para avaliar a resposta ao tratamento e ajustar as estratégias conforme necessário. A utilização de métodos de imagem, como ressonância magnética e tomografia computadorizada, aliada a exames laboratoriais especializados, permite uma análise mais precisa da evolução da doença e seus efeitos no organismo infantil. O acompanhamento frequente dos pacientes é fundame

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Schräder, Josele da Rocha, Leonara Leite Vidal, Cícero Thiago Moreira Alves, et al. "Uma análise da Leucemia Linfóide Aguda em crianças com Síndrome de Down: uma revisão de literatura." Caderno Pedagógico 21, no. 8 (2024): e7204. http://dx.doi.org/10.54033/cadpedv21n8-260.

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Introdução: A leucemia linfocítica aguda (LLA) é uma doença degenerativa causada pela proliferação clonal de células progenitoras linfóides. Objetivo: Observar a correlação da LLA com a Síndrome de Down (SD) e como isso afeta as crianças com SD. Metodologia: Trata-se de uma revisão integrativa de literatura, a procura por artigos foi realizada durante os meses de dezembro de 2022 e fevereiro de 2023, utilizando as bases de dados SciElo, BVS e LILACS. Os descritores em saúde, retirados dos Descritores em Ciências da Saúde (DeCs), foram: Síndrome de Down; Pediatria; Leucemia Linfóide Aguda. Fora

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Yalçın, Koray, Ersin Erhal, Melih Yıldırım, et al. "Pediyatrik Kanser Hastalarında Otolog Kök Hücre Toplama İşlemine Etki Eden Faktörlerin Değerlendirilmesi." LLM Dergi 6, no. 1 (2022): 9–15. http://dx.doi.org/10.5578/llm.20229902.

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Objective: Pediatric cancer patients comprise a fragile patient group regarding age and intensive therapy. It is known that factors like apheresis machine, characteristics of patients, primary disease, and cellular parameters before the process impact the efficacy of stem cell apheresis. In this study, we aim to evaluate the characteristic features of stem cell apheresis and the influencing factors of the process. Patients and Methods: This study involves 42 patients who received a total of 88 aphereses, between August 2012-March 2021in our pediatric stem cell transplantation unit. All of the

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Silva, Dandara Cristina da, Naiara Pereira Rodrigues, Sângela de Jesus, and Afrânio Côgo Destefanio. "AVANÇOS NA TERAPIA COM CÉLULAS CAR-T PARA LEUCEMIA LINFOBLÁSTICA AGUDA EM PEDIATRIA: UM ENFOQUE EM EFETIVIDADE CLÍNICA E PERSPECTIVAS FUTURAS." Centro de Pesquisas Avançadas em Qualidade de Vida 16, V16N1 (2024): 1. http://dx.doi.org/10.36692/v16n1-149r.

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A leucemia linfoblástica aguda (LLA) é o câncer mais comum na infância, representando uma parte significativa das leucemias pediátricas. Apesar dos avanços na quimioterapia, uma proporção substancial de pacientes pediátricos ainda enfrenta recidiva ou resistência ao tratamento. A terapia com células CAR-T (Chimeric Antigen Receptor T-cell) surgiu como uma abordagem inovadora para neoplasias hematológicas refratárias e recidivantes. Este estudo tem como objetivo avaliar a eficácia e segurança da terapia com células CAR-T no tratamento de LLA em crianças. Foram incluídos estudos publicados nos ú

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ÜNAL İNCE, Elif, Gül Hatice ERKOL TUNCER, Talia İLERİ, et al. "Impact of ABO Incompatibility on Pediatric Haematopoietic Stem Cell Transplantation." LLM Dergi 2, no. 1 (2018): 9–14. http://dx.doi.org/10.5578/llm.66211.

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Casagrande, Lucas Zuccolotto, Fernanda Paiva Yenikomshian, Gustavo Angelo Medeiros, Julia Dias Ribeiro Neta, Leonardo Costa Grespan, and Leonardo Reinert Hilgert. "TECNOLOGÍA CAR-T EN EL MANEJO DE LA LEUCEMIA LINFOBLÁSTICA AGUDA DE CÉLULAS T:." Revista Ibero-Americana de Humanidades, Ciências e Educação 10, no. 7 (2024): 2936–46. http://dx.doi.org/10.51891/rease.v10i7.15011.

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A leucemia linfoblástica aguda de células T (LLA-T) é um tipo de neoplasia maligna que afeta a linhagem linfocítica T, e é um dos mais comuns na pediatria oncológica. Consiste na proliferação descontrolada de células progenitoras hematopoiéticas e pode se tornar um tumor bastante agressivo em alguns casos. Entretanto, a utilização da técnica de células CAR-T pode frear a enfermidade e levar à remissão pacientes que não reagiram aos tratamentos convencionais - como quimioterapia e transplante de medula. O presente trabalho busca apresentar a utilização da técnica CAR-T no tratamento da LLA-T em

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Moreira, Karina Andrade, Ana Lucia Miranda de Carvalho, Marcia Trindade Schramm, Renata Brum Martucci, Leonardo Borges Murad, and Danúbia da Cunha Antunes Saraiva. "Estado Nutricional de Pacientes Pediátricos Recém-Diagnosticados com Leucemia Linfoblástica Aguda em um Instituto de Referência em Oncologia do Rio de Janeiro." Revista Brasileira de Cancerologia 64, no. 3 (2019): 349–55. http://dx.doi.org/10.32635/2176-9745.rbc.2018v64n3.35.

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Introdução: A leucemia linfoblástica aguda (LLA ) constitui a neoplasia mais comum em pediatria e a avaliação nutricional é um instrumento essencial para conhecer as condições de saúde dos pacientes. O presente estudo teve como objetivo avaliar e descrever o estado nutricional de pacientes pediátricos recém-diagnosticados com LLA e verificar a relação do índice de massa corporal para idade (IMC/I) com as demais medidas antropométricas. Método: Estudo observacional, transversal, realizado com pacientes de 1 a 18 anos, recém-diagnosticados com LLA , no período de janeiro/2004 a dezembro/2009. Os

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Verma, P., A. Jhanwar, and R. R. Singh. "The influence of prenatal screening on the contemporary operative outcomes and functional alleviation after vascular ring surgery in children." CARDIOMETRY, no. 26 (March 1, 2023): 842–48. http://dx.doi.org/10.18137/cardiometry.2023.26.842848.

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Objective: The impact of prenatal screening on contemporary operative outcomes and functional alleviation during pediatric Vascular Ring Surgery (VRS) is analysed in this research. Methods:All patients who had surgical treatment of an isolated VR at the Texas Children’s Hospitalbetween 1996 and 2018were included in the study. Patients who simultaneously underwent intracardiac repair were disqualified. Other congenital cardiac conditions, clinical symptomatology, contemporary surgical intervention, perioperative outcome, reoperation rates, functional alleviation, and complications were all exam

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Reshetov, Igor V., and Natalia I. Usoltseva. "To the 75th anniversary of Academician of the Russian Academy of Sciences Vladimir G. Polyakov." Annals of the Russian academy of medical sciences 79, no. 6 (2024): 563–64. https://doi.org/10.15690/vramn18042.

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On September 14, 2024, an outstanding scientist in the field of pediatric oncology, Honored Healthcare Worker of the Russian Federation, head of the Department of Pediatric Oncology named after Academician L.A. Durnov, Federal State Budgetary Educational Institution of the Russian Ministry of Health, Advisor to the Director of the L.A. Durnov Research Institute of Pediatric Oncology and Hematology of the Federal State Budgetary Institution “National Medical Research Center of Oncology named after N.N. Blokhina” Ministry of Health of the Russian Federation, Doctor of Medical Sciences, Professor

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TJ, Syntia, Endang Retnowati, Yetti Hernaningsih, I. Dewa Gede Ugrasena, and Soeprapto Ma’at. "COMPARISON OF PERIPHERAL BLOOD ACTIVATED NK CELL PERCENTAGE BEFORE AND AFTER INDUCTION PHASE CHEMOTHERAPY IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA (Perbandingan Persentase Sel NK Teraktivasi Darah Tepi Sebelum dan Sesudah Kemoterapi Tahap Induksi di Pasien Leukemia Limfoblastik Akut Anak)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 23, no. 3 (2018): 281. http://dx.doi.org/10.24293/ijcpml.v23i3.1208.

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Leukemia Limfoblastik Akut (LLA) adalah keganasan sel progenitor limfoid yang berasal dari sumsum tulang dan ditandai proliferasileukosit. Kejadian LLA masih tinggi, sehingga perlu diteliti peran sel NK dalam melawan leukemia. Tujuan penelitian adalah untukmengetahui perbedaan persentase sel NK teraktivasi sebelum dan sesudah pengobatan induksi dan hubungan persentase sel NK teraktivasisebelum pengobatan induksi dengan keluaran kemoterapi pasien LLA anak. Penelitian analitik observasional dengan rancang banguncohort prospektif. Subjek penelitian 27 pasien di Ruang Rawat Inap Hemato-Onkologi An

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Pedrosa, Francisco, and Mecneide Lins. "Leucemia linfóide aguda: uma doença curável." Revista Brasileira de Saúde Materno Infantil 2, no. 1 (2002): 63–68. http://dx.doi.org/10.1590/s1519-38292002000100010.

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RESUMO: Leucemia linfóide Aguda (LLA), é o tipo mais comum de câncer infantil, constituindo cerca de um terço de todas as neoplasias malignas da criança. A incidência de LLA em crianças nos Estados Unidos é aproximadamente de 3,4 casos por 100.000 crianças menores de 15 anos de idade. Até a metade do século passado, as leucemias eram consideras universalmene, uma doença fatal. O desenvolvimento de combinações terapêuticas, utilizando diversas drogas citotóxicas com ou sem transplante de medula óssea, tem aumentado o percentual de cura da criança portadora de Leucemia linfóide Aguda em mais de

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Nur’Aini, Farida, Endang Retnowati, Yetti Hernaningsih, and Mia Ratwita A. "COMPARISON OF PERCENTAGE PERIPHERAL BLOOD LYMPHOBLAST PROLIFERATION AND APOPTOSIS IN PEDIATRIC ACUTE LYMPHOBLASTIC LEUKEMIA BEFORE AND AFTER CHEMOTHERAPY INDUCTION PHASE (Perbandingan Persentase Proliferasi dan Apoptosis Limfoblas di Darah Tepi di Pasien Leukemia Limfoblastik Akut Anak Sebelum dan Sesudah Kemoterapi Tahap Induksi)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 23, no. 3 (2018): 263. http://dx.doi.org/10.24293/ijcpml.v23i3.1205.

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Leukemia Limfoblastik Akut (LLA) adalah penyakit neoplasma yang dihasilkan dari perpindahan somatik multistep progenitorlimfoid di sumsum tulang, ditandai maturation arrest, proliferasi tidak terkendali seri limfoid serta penumpukan limfoblas di sumsumtulang dan darah tepi. Kelainan terkait aktivitas proliferasi sel berkaitan dengan kendali apoptosis. Penelitian ini bertujuan mengetahuiperbandingan persentase proliferasi dan apoptosis limfoblas di darah tepi pasien LLA anak sebelum dan sesudah kemoterapi tahapinduksi. Subjek penelitian sebesar 12 pasien LLA anak kasus baru yang diperiksa sebel

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Nasr, BP, NS Santosnan, E. Delbuono, et al. "RECONHECIMENTO DE LLA PH-LIKE COM A INTEGRAÇÃO DOS MÉTODOS DIAGNÓSTICOS: EXPERIÊNCIA EM PEDIATRIA." Hematology, Transfusion and Cell Therapy 45 (October 2023): S226. http://dx.doi.org/10.1016/j.htct.2023.09.466.

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Rusanti, Rahmi, Yetti Hernaningsih, Endang Retnowati, Mia Ratwita Andarsini, and Andy Cahyadi. "CORRELATION OF BLAST PERCENTAGE TO CD34 OF BONE MARROW IN ALL PEDIATRIC PATIENTS." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 24, no. 1 (2018): 53. http://dx.doi.org/10.24293/ijcpml.v24i1.1156.

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Leukemia Limfoblastik Akut (LLA) adalah penyakit keganasan sel progenitor limfoid yang berasal dari sumsum tulang. Tanda khasdari diagnosis leukemia akut adalah sel blas. Pemeriksaan mikroskopis dilakukan untuk menentukan persentase sel blas pada diagnosisleukemia akut. Immunophenotyping merupakan metode diagnostik yang dapat membantu menegakkan diagnosis pada keganasanhematologi. CD34 merupakan antigen yang sering digunakan untuk identifikasi sel induk hemopoeisis atau blas. Penelitian ini bertujuanuntuk mengetahui kenasaban antara persentase blas dengan ekspresi CD34 di sumsum tulang di pasi

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Salem, Ronza, Jonathan Lorber, and Ron Karmeli. "LEA 25. Pediatric Penetrating Injury of Popliteal Fossa." Journal of Vascular Surgery 70, no. 5 (2019): e124. http://dx.doi.org/10.1016/j.jvs.2019.08.042.

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Wicaksono, Sony, Mia Ratwita Andarsini, I. Dewa Gede Ugrasena, Andi Cahyadi, Maria Christina Shanty Larasati, and Susanto Nugroho. "Hematologic Recovery in Pediatric Patients with Acute Lymphoblastic Leukemia After Induction Chemotherapy." Bali Medical Journal 13, no. 1 (2023): 143–47. http://dx.doi.org/10.15562/bmj.v13i1.4910.

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Link of Video Abstract: https://youtu.be/ulLjSscae2Q Introduction: Myelosuppression in Acute Lymphoblastic Leukemia (ALL) children was associated with high morbidity and mortality. Chemotherapy was aimed to achieve remission conditions, including the elimination of blast cells in the bone marrow. However, the evidence of hematologic recovery after induction chemotherapy was poorly described. This study aimed to evaluate the profile of peripheral blood and the outcome of children with ALL after induction chemotherapy. Methods: A prospective study was conducted in the Hematology-Oncology Pediatr

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Rykov, M. Yu, and V. G. Polyakov. "THE HISTORY OF PEDIATRIC ONCOLOGY IN THE USSR-RUSSIA: THE 40TH ANNIVERSARY OF THE INSTITUTE OF PEDIATRIC ONCOLOGY AND HEMATOLOGY OF THE N.N. BLOKHIN RUSSIAN CANCER RESEARCH CENTER AND THE 20TH ANNIVERSARY OF PEDIATRIC ONCOLOGY." Russian Journal of Oncology 22, no. 2 (2017): 107–12. http://dx.doi.org/10.18821/1028-9984-2017-22-1-107-112.

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The article describes the history of the selection of pediatric oncology as a separate specialty, the organization of first oncological departments and the creation of the first in the USSR Research Institute of Pediatric Oncology and Hematology. There is described the role of academician L.A. Durnov as the founder of oncopediatrics in the national health care

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Lehane, Alison J., Gwyneth A. Sullivan, Jennifer B. Dunn, et al. "538 Life Cycle Analysis of a Single Use Laryngoscope – A Target to Reduce Operating Room Environmental Impact." Journal of Clinical and Translational Science 8, s1 (2024): 160. http://dx.doi.org/10.1017/cts.2024.459.

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OBJECTIVES/GOALS: Health care accounts for an estimated 10% of U.S. greenhouse gas (GHG) emissions. Concerted efforts to decrease waste are needed including critical appraisal of single use items. The purpose of this study was to conduct life cycle analyses (LCA) of a pediatric single use laryngoscope to inform environmental impact and identify targets to reduce waste. METHODS/STUDY POPULATION: LCA was used to quantify the environmental impact of a single use pediatric laryngoscope. LCA is an industry standard measure of energy consumption, water consumption, and GHG emissions encompassing a “

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Villadiego Peña, Shirly Carolina, Luisa Fernanda Ruiz Espitia, Wilson José German Serpa, Fabio Javier Molina-Morales, and Sara Cecilia Soto-De León. "Caracterización de leucemia linfoide aguda en pacientes con protocolo BFM-ALLIC-2009 en fase de inducción. Montería (Córdoba), Colombia." Pediatría 55, no. 2 (2022): 51–59. http://dx.doi.org/10.14295/rp.v55i2.281.

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Objetivo. Caracterizar los pacientes con leucemia linfoide aguda (LLA) que recibieron protocolo BFM-ALL IC-2009 en la fase de inducción entre los años 2014 y 2019 en la clínica IMAT de la ciudad de Montería, Córdoba, Colombia. Métodos. Estudio retrospectivo de corte transversal, de pacientes pediátricos con diagnóstico de LLA, en los que se aplicó el protocolo BFM-ALL-IC-2009 en fase de inducción, caracterizando la población según origen y sexo, e identificando asociaciones con variables sociodemográficas, por medio de una regresión logística ordinal con estratificación. Resultados. Se incluye

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Yustinadewi, Putu Desy, Putu Sanna Yustiantara, and Inna Narayani. "MDR-1 GENE 1199 VARIANT PRIMER DESIGN TECHNIQUES IN PEDIATRIC PATIENT BUFFY COAT SAMPLES WITH LLA." Metamorfosa: Journal of Biological Sciences 5, no. 1 (2018): 105. http://dx.doi.org/10.24843/metamorfosa.2018.v05.i01.p16.

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Single Nucleotide Polymorphism (SNP) 1199 dapat diidentifikasi menggunakan sampel buffy coat dengan metode Polymerase Chain Reaction (PCR). Komponen- komponen yang diperlukan pada proses PCR adalah template DNA; sepasang primer, yaitu suatu oligonukleotida pendek yang mempunyai urutan nukleotida yang komplementer dengan urutan nukleotida DNA templat; dNTPs (Deoxynucleotide triphosphates); buffer PCR; magnesium klorida (MgCl2) dan enzim polimerase DNA (Handoyo dan Rudiretna, 2001). Primer sangat mempengaruhi spesifitas dan sensitivitas reaksi PCR. Rancangan suatu primer merupakan salah satu par

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Boissel, Nicolas, Marie-Françoise Auclerc, Véronique Lhéritier, et al. "Should Adolescents With Acute Lymphoblastic Leukemia Be Treated as Old Children or Young Adults? Comparison of the French FRALLE-93 and LALA-94 Trials." Journal of Clinical Oncology 21, no. 5 (2003): 774–80. http://dx.doi.org/10.1200/jco.2003.02.053.

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Purpose: To compare pediatric and adult therapeutic practices in the treatment of acute lymphoblastic leukemia (ALL) in adolescents. Patients and Methods: From June 1993 to September 1994, 77 and 100 adolescents (15 to 20 years of age) were enrolled in the pediatric FRALLE-93 and adult LALA-94 protocols, respectively. Among the different prognostic factors, we retrospectively analyzed the effect of the trial on achieving complete remission (CR) and event-free survival (EFS). Results: Patients were younger in the FRALLE-93 than in the LALA-94 protocol (median age, 15.9 v 17.9 years, respectivel

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Ovalle B., Pilar, Manuel Azócar M., Carolina Nicklas D., Milena Villarroel C., and Jorge Morales V. "Reacciones de hipersensibilidad asociadas al uso de asparaginasa en niños con leucemia linfoblástica aguda." Andes Pediatrica 92, no. 2 (2021): 182. http://dx.doi.org/10.32641/andespediatr.v92i2.2151.

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El tratamiento de la leucemia linfoblástica aguda (LLA) incluye el uso de asparaginasa (ASP), medicamento asociado a reacciones de hipersensibilidad (RHS) que requieren discontinuar su uso.Objetivo: Determinar la incidencia de RHS asociadas a ASP que requieran discontinuar su uso y describirlas, y verificar si hay asociación entre incidencia de RHS y protocolos o sobrevida.Pacientes y Método: Estudio retrospectivo. Se revisaron los registros clínicos de todos los pacientes (1-15 años) diagnosticados de LLA entre enero de 2010 y diciembre de 2015 en el Hospital Luis Calvo Mackenna. Se determinó

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Özer, Zeynep. "Leveraging machine learning for improved outcomes in pediatric appendicitis diagnosis and management." Journal of Innovative Engineering and Natural Science 5, no. 2 (2025): 490–506. https://doi.org/10.61112/jiens.1592608.

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Pediatric appendicitis, as a critical condition, represents clinical challenges in both diagnostic and treatment management due to the variability in its presentation and the absence of a specific biomarker for both diagnosis and outcome prediction. Leveraging Machine Learning (ML) algorithms, this study aims to improve diagnostic accuracy and treatment strategies utilizing a robust dataset from the Children’s Hospital St. Hedwig in Regensburg, Germany, containing extensive clinical data and a broad spectrum of patient demographics. We evaluated the efficiency of three ML techniques, including

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Leite, Edinalva Pereira, Maria Tereza Cartaxo Muniz, Alita da Cunha Andrade Cirne de Azevedo, et al. "Fatores prognósticos em crianças e adolescentes com Leucemia Linfóide Aguda." Revista Brasileira de Saúde Materno Infantil 7, no. 4 (2007): 413–21. http://dx.doi.org/10.1590/s1519-38292007000400009.

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OBJETIVOS: descrever características clínico-laboratoriais, determinar taxas de resposta ao tratamento e identificar fatores de risco que influenciaram na sobrevida de pacientes pediátricos com leucemia linfóide aguda (LLA). MÉTODOS: estudo retrospectivo do tipo série de casos com 108 pacientes de idade até 18 anos, admitidos para tratamento de LLA na Fundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Brasil, de janeiro de 1993 a dezembro de 2001. As variáveis analisadas foram: sexo, idade, principais sintomas e sinais, leucometria, imunofenótipo e grupo de risco ao diagnóstico, tax

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Consuelo-Sánchez, Alejandra, Rodrigo Vázquez-Frías, Alejandra Reyes-De la Rosa, Carlos P. Acosta-Rodríguez-Bueno, María P. Ortal-Vite, and Jorge J. Cebolla. "Mutations Identified in a Cohort of Mexican Patients with Lysosomal Acid Lipase Deficiency." Annals of Hepatology 17, no. 5 (2018): 0–10. http://dx.doi.org/10.5604/01.3001.0012.4899.

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Introduction and aim. Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive disease caused by mutations in the LIPA gene, located on the long arm of chromosome 10 (10q23.31). Up until now, more than 59 mutations have been described and which are the cause of a very wide clinical spectrum. The goal of this study was to identify the mutations present in Mexican pediatric patients with a diagnosis of LAL-D. Material and methods. A cross-sectional study was carried out which included all the pediatric patients with LAL-D treated in a tertiary hospital in Mexico from January 2000 to Ju

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Karbalivand, H., A. Iyare, A. Aponte, X. Xianhong, M. Kim, and T. Havranek. "Hypoglycemia screening of asymptomatic newborns on the 2nd day of life." Journal of Neonatal-Perinatal Medicine 15, no. 2 (2022): 311–16. http://dx.doi.org/10.3233/npm-210861.

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BACKGROUND: Neonatal hypoglycemia management in the first 48 hours is guided by the American Academy of Pediatrics (AAP) and Pediatric Endocrine Society (PES) recommendations. Our aim was to determine the incidence of hypoglycemia via point of care test (POCT) on the 2nd day of life (DOL) among healthy, asymptomatic neonates regardless of risk factors. METHODS: In this prospective observational study, preprandial point of care glucose concentration was measured on the 2nd DOL in 150 healthy, asymptomatic neonates in the newborn nursery. We used 50 mg/dl (2.8 mmol/L) as the hypoglycemia thresho

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Feick, Emma, Peggy-Rae Hamilton, Marlene Luis, et al. "A pilot study examining measures of balance and mobility in children with unilateral lower-limb amputation." Prosthetics and Orthotics International 40, no. 1 (2014): 65–74. http://dx.doi.org/10.1177/0309364614560941.

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Background:Individuals with unilateral lower-limb amputation (LLA) have altered structure and physiology of their lower limbs which impairs their balance, mobility, physical function and participation in physical activities. As part of (re)habilitation, focus is given to improving gait and balance in order to enhance overall mobility, function, self-efficacy, and independence. However, the relationships amongst body impairments and physical activity limitations remain unclear, particularly in the pediatric population.Objective:To provide an examination of the relationships among balance and mo

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Huguet, Françoise, Emmanuel Raffoux, Xavier Thomas, et al. "Towards a Pediatric Approach in Adults with Acute Lymphoblastic Leukemia (ALL): The GRAALL-2003 Study." Blood 108, no. 11 (2006): 147. http://dx.doi.org/10.1182/blood.v108.11.147.147.

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Abstract Introduction: In a recent French FRALLE versus LALA comparison, we have demonstrated a large benefit in outcome when adolescents and young adults were treated in a pediatric rather than an adult ALL protocol (Boissel JCO 2003). Similar provocative results have been observed in three other pediatric versus adult ALL studies (Stock ASH 2000, de Bont Leukemia 2004, Testi ASH 2004). One explanation may be the larger amounts of steroids, vincristine (VCR), and L-asparaginase (L-aspa) administered in pediatric patients. The GRAALL-2003 study was thus designed to offer a pediatric approach i

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Crary, Shelley V., Lilianne B. McKissack, Joana M. Mack, Saritha Ranabothu, Megan E. Rogers, and Shelley E. Crary. "Hypercoagulability Evaluation in Pediatric Kidney Transplant Recipients to Optimize Outcomes." Blood 144, Supplement 1 (2024): 5022. https://doi.org/10.1182/blood-2024-212269.

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Introduction: Kidney transplant has been shown to be the best treatment for children with end-stage kidney disease. Graft thrombosis is a well-recognized complication following kidney transplant and is one of the leading causes of early graft loss. Hypercoagulability has been implicated as a risk factor leading to graft thrombosis. Pre-transplant hypercoagulability evaluation can guide prophylactic strategies to mitigate thrombotic events and early graft loss, yet utility of universal screening for hypercoagulability in the pre-transplant population remains controversial. We report a single ce

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Almira, Isni Dhiyah, and Selvi Nafianti. "Hubungan Pemberian Kortikosteroid terhadap Kenaikan Berat Badan pada Anak Penderita Leukemia Limfoblastik Akut Fase Induksi di RSUP Haji Adam Malik Medan." SCRIPTA SCORE Scientific Medical Journal 2, no. 2 (2021): 76–83. http://dx.doi.org/10.32734/scripta.v2i2.3409.

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Background: Glucocorticoid corticosteroids have vasoconstrictive, anti-proliferation, anti-inflammatory, and immunosuppressant effects through interactions with glucocorticoid receptors which have also been found in one type of leukemia, acute lymphoblastic leukemia (ALL). The most common side effect long-term use of high dose corticosteroids is increase in body weight resulting in obesity. It is one of the main problems in ALL patients, because it leads to persistent leukemia, increase of the risk of recurrence, and poor event-free survival. This has been associated with the use of glucocorti

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Kessous, Roy, Eyal Sheiner, Daniella Landau, and Tamar Wainstock. "A History of Large for Gestational Age at Birth and Future Risk for Pediatric Neoplasms: A Population-Based Cohort Study." Journal of Clinical Medicine 9, no. 5 (2020): 1336. http://dx.doi.org/10.3390/jcm9051336.

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Objective: The aim of this study was to evaluate the association between large for gestational age (LGA) at birth and future risk of childhood neoplasm. Study design: a population-based cohort to compare the long-term risk (up to the age of 18 years) of childhood neoplasms (benign and malignant) in children that were born LGA vs. those that were appropriate for gestational age (AGA), between the years 1991–2014. Childhood neoplasms diagnosis were defined according to international classification of disease 9 (ICD-9) codes recorded medical files. Kaplan–Meier survival curves were used in order

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Ashutosh, Ranjan, and Kumar Mahesh. "Comparison of Videolaryngoscopy and Direct Laryngoscopy for Tracheal Intubation in Paediatric Patients." International Journal of Pharmaceutical and Clinical Research 16, no. 6 (2024): 2475–77. https://doi.org/10.5281/zenodo.13851666.

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This prospective, randomized controlled trial conducted at Jawahar Lal Nehru Medical College & Hospital, Bhagalpur, Bihar, from February 2023 to January 2024, compared video laryngoscopy (VL) and direct laryngoscopy (DL) in 100 pediatric patients undergoing tracheal intubation. The study aimed to assess first-attempt success rates, glottic visualization quality, intubation duration, airway-related complications, and patient stress indicators. Results demonstrated that VL significantly outperformed DL, achieving higher first-attempt success rates (88% vs. 68%), superior glottic views (92% G

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Campbell, Elizabeth A., Mitchell G. Maltenfort, Justine Shults, Christopher B. Forrest, and Aaron J. Masino. "Characterizing clinical pediatric obesity subtypes using electronic health record data." PLOS Digital Health 1, no. 8 (2022): e0000073. http://dx.doi.org/10.1371/journal.pdig.0000073.

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In this work, we present a study of electronic health record (EHR) data that aims to identify pediatric obesity clinical subtypes. Specifically, we examine whether certain temporal condition patterns associated with childhood obesity incidence tend to cluster together to characterize subtypes of clinically similar patients. In a previous study, the sequence mining algorithm, SPADE was implemented on EHR data from a large retrospective cohort (n = 49 594 patients) to identify common condition trajectories surrounding pediatric obesity incidence. In this study, we used Latent Class Analysis (LCA

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Buczyńska, Anna, and Urszula Grzybowska-Chlebowczyk. "Prognostic Factors of Biologic Therapy in Pediatric IBD." Children 9, no. 10 (2022): 1558. http://dx.doi.org/10.3390/children9101558.

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This was a retrospective cohort study aimed at identifying parameters measured at diagnosis of pediatric IBD to predict subsequent biologic therapy, as an equivalent to an unfavorable clinical course. Identification of predictors of poor outcomes is an important issue in current ECCO guidelines on pIBD. The study population consisted of 119 children with Crohn’s disease and 112 with ulcerative colitis, diagnosed and monitored for at least 1 year from 2009–2019. The population was divided into the study groups separately: 39 children with CD and 14 with UC who received biologics before the age

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Ben Abdelali, Raouf, Vahid Asnafi, Thibaut Leguay, et al. "Pediatric-inspired intensified therapy of adult T-ALL reveals the favorable outcome of NOTCH1/FBXW7 mutations, but not of low ERG/BAALC expression: a GRAALL study." Blood 118, no. 19 (2011): 5099–107. http://dx.doi.org/10.1182/blood-2011-02-334219.

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Abstract Despite recent progress in the understanding of acute lymphoblastic leukemia (T-ALL) oncogenesis, few markers are sufficiently frequent in large subgroups to allow their use in therapeutic stratification. Low ERG and BAALC expression (E/Blow) and NOTCH1/FBXW7 (N/F) mutations have been proposed as powerful prognostic markers in large cohorts of adult T-ALL. We therefore compared the predictive prognostic value of N/F mutations versus E/Blow in 232 adult T-ALLs enrolled in the LALA-94 and Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) protocols. The outcome of T-ALLs

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Safin, D. A., N. E. Gorbatova, S. A. Zolotov та ін. "The first experience of treating linear types of capillary angiodysplasia of the skin in children with green laser light λ 520 ± 10.0 nm". Russian Journal of Pediatric Surgery 27, № 4 (2023): 277–83. http://dx.doi.org/10.55308/1560-9510-2023-27-4-277-283.

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Introduction. The linear type of capillary angiodysplasia (LCA) is represented by pathologically dilated vessels of the capillary flow located between the epidermis and hypodermis. LCA may be both congenital and acquired. By the type of blood supply, LCA are arterial, venous and mixed. Local infections and injuries, excessive solar insolation and hormonal imbalance are noted among LCA causes. LCAs are benign lesions, but they may have complications which may be triggered, for example, by traumatic damage to a pathologically enlarged vessel. There is a large number of non-invasive and invasive

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Saini, Shelly, Andrew Y. Koh, and Ayesha Zia. "Identifying Gut Microbiota and Immune Host Factors Associated with Bleeding Risk in Children with Immune Thrombocytopenic Purpura." Blood 144, Supplement 1 (2024): 2551. https://doi.org/10.1182/blood-2024-199928.

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Background: Immune thrombocytopenia (ITP) may cause clinically significant bleeding episodes that can adversely affect a patient's quality of life. The gut microbiome plays a critical role in host immune system education and response in both healthy and diseased states. Previous studies comparing microbial taxa and cytokine levels in ITP patients have focused on differences between healthy controls and ITP participants. The role of the microbiome and cytokine levels in bleeding risk among ITP patients remains unclear. Methods: In our prospective cohort study, we analyzed stool and blood sample

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Danniele, Santos Andrade de Lavôr, and Cândida Pereira Mayara. "Potencialidades e fragilidades nos cuidados paliativos de enfermagem em pediatria: uma revisão integrativa." Revista JRG de Estudos Acadêmicos 6, no. 13 (2023): 1147–57. https://doi.org/10.5281/zenodo.8087111.

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<strong>Objetivo: </strong>Investigar os fatores que potencializam e fragilizam a assistência de Enfermagem às crianças em cuidados paliativos. <strong>Materiais e Métodos: </strong>Revisão integrativa da literatura realizada nas bases de dados SciELO, LILACS e BDENF entre os meses de junho de 2021 e abril de 2022, as quais geraram 517 referências. Após remoção dos artigos pesquisados, foi utilizados critérios de inclusão e exclusão, a amostra final foi composta por 6 artigos. <strong>Resultados: </strong>A boa r

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Úriz Monaut, J. J., N. García de Andoin Barandiaran, P. Esparza Paz, et al. "Tratamiento y profilaxis secundaria con voriconazol en un paciente pediátrico con lla y aspergilosis pulmonar." Anales de Pediatría 66, no. 3 (2007): 333–34. http://dx.doi.org/10.1016/s1695-4033(07)70415-0.

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Pombo, M., M. L. Couce, J. M. Couselo, and J. Devesa. "56 NEUROENDOCRINE ALTERATIONS INDUSCED BY CRANIAL IRRADIATION (CR) IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (LLA)." Pediatric Research 24, no. 4 (1988): 526. http://dx.doi.org/10.1203/00006450-198810000-00077.

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Bravo-Valenzuela, Nathalie Jeanne Magioli, and Guilherme Ricardo Nunes Silva. "Aneurysm of the Left Coronary Artery in Postoperative Bland-White-Garland Syndrome." Case Reports in Cardiology 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/568014.

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We report a case of anomalous left coronary artery from the pulmonary artery (ALCAPA) or Bland-White-Garland syndrome, present the challenges of performing a differential diagnosis, and discuss the treatment of the syndrome. Although ALCAPA is a rare congenital heart disease, it is one of the most common causes of myocardial ischemia in childhood and presents a diagnostic challenge. A four-year-old girl was referred to a pediatric cardiologist for evaluation of mitral valve regurgitation murmur and heart failure. The transthoracic echocardiogram demonstrated the left coronary artery (LCA) not

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Levitch, Cara, Alice Ann Holland, Jesse Bledsoe, et al. "QOL-11. Comparison of Neuropsychological Functioning in Pediatric Posterior Fossa Tumor Survivors: Medulloblastoma, Low-Grade Astrocytoma, and Healthy Controls." Neuro-Oncology 24, Supplement_1 (2022): i135. http://dx.doi.org/10.1093/neuonc/noac079.494.

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Abstract BACKGROUND: Neuropsychological comparison of medulloblastoma (MB) and cerebellar low-grade astrocytoma (LGA) survivors to controls can clarify treatment-related neurocognitive late effects. While both brain tumor groups undergo surgery to the posterior fossa, children with MB additionally receive craniospinal irradiation with boost and chemotherapy. This study provides an updated comparison of neuropsychological functioning in these two groups and examines effects of demographic risk factors upon outcomes. PROCEDURE: Forty-two children (16 MB, 9 LGA, 17 controls) completed measures of

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Arai, Katsuhiro, Reiko Kunisaki, Fumihiko Kakuta, et al. "Phenotypic characteristics of pediatric inflammatory bowel disease in Japan: results from a multicenter registry." Intestinal Research 18, no. 4 (2020): 412–20. http://dx.doi.org/10.5217/ir.2019.00130.

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Background/Aims: There are few published registry studies from Asia on pediatric inflammatory bowel disease (IBD). Registry network data enable comparisons among ethnic groups. This study examined the characteristics of IBD in Japanese children and compared them with those in European children.Methods: This was a cross-sectional multicenter registry study of newly diagnosed Japanese pediatric IBD patients. The Paris classification was used to categorize IBD features, and results were compared with published EUROKIDS data.Results: A total of 265 pediatric IBD patients were initially registered,

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Huguet, Françoise, Thibaut Leguay, Emmanuel Raffoux, et al. "Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study." Journal of Clinical Oncology 27, no. 6 (2009): 911–18. http://dx.doi.org/10.1200/jco.2008.18.6916.

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Purpose Retrospective comparisons have suggested that adolescents or teenagers with acute lymphoblastic leukemia (ALL) benefit from pediatric rather than adult chemotherapy regimens. Thus, the aim of the present phase II study was to test a pediatric-inspired treatment, including intensified doses of nonmyelotoxic drugs, such as prednisone, vincristine, or l-asparaginase, in adult patients with ALL up to the age of 60 years. Patients and Methods Between 2003 and 2005, 225 adult patients (median age, 31 years; range, 15 to 60 years) with Philadelphia chromosome–negative ALL were enrolled onto t

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Kuryaninova, V. A., E. A. Cherkasova, T. V. Strokova, et al. "Lysosomal acid lipase deficiency and its clinical pathophysiology, enzyme replacement therapy features: bibliographical review and a case report." Pediatria. Journal named after G.N. Speransky 103, no. 5 (2024): 108–17. http://dx.doi.org/10.24110/0031-403x-2024-103-5-108-117.

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Lysosomal acid lipase deficiency (LALD) is a rare disease of lysosomal storage inherited in an autosomal recessive manner and caused by damaging mutations in the LIPA gene encoding the synthesis of the enzyme lysosomal acid lipase (LAL). Authors represent basic information about LALD, describe its typical clinical and laboratory manifestations, features of enzyme replacement therapy with Sebelipase alfa (sold under the brand name KANUMA®), which is a recombinant form of the enzyme LAL, outcomes and prognosis of the disease in children. Modern methods for the LALD detection and an algorithm for

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Furtado, FM, LA Pinheiro, ER Biojone, et al. "IMPLEMENTAÇÃO DE TRATAMENTO PARA LLA EM PEDIATRIA COM INTENSIDADE AJUSTADA À DRM MEDIDA POR CITOMETRIA DE FLUXO DE NOVA GERAÇÃO." Hematology, Transfusion and Cell Therapy 43 (October 2021): S288. http://dx.doi.org/10.1016/j.htct.2021.10.487.

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Patni, Maninder, Uday Pratap, Ruchi Sarawgi, and Ruchi Gupta. "Compare the Clinical Profile of Pediatric Patients in either Deep or Awake State underSevoflurane Anaesthesia afterthe Removal of Proseal LMA." Academia Anesthesiologica International 4, no. 2 (2019): 136–41. http://dx.doi.org/10.21276/aan.2019.4.2.32.

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Finnveden, Göran, Rickard Arvidsson, Anna Björklund, Jeroen Guinée, Reinout Heijungs, and Michael Martin. "Six areas of methodological debate on attributional life cycle assessment." E3S Web of Conferences 349 (2022): 03007. http://dx.doi.org/10.1051/e3sconf/202234903007.

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There is a general agreement in the LCA community that there are two types of LCAs: attributional and consequential. There have been numerous discussions about the pros and cons of the two approaches and on differences in methodology, in particular about methods that can be used in consequential LCA. There are, however, methodological aspects of attributional LCA and how it can be used that need further attention. This article discusses six areas of debate and potential misunderstandings concerning attributional LCA. These are: 1) LCA results of all the products in the world should add up to t

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