Littérature scientifique sur le sujet « Lipid nanoparticles of nonlamellar lipids »
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Articles de revues sur le sujet "Lipid nanoparticles of nonlamellar lipids"
Mertins, Omar, Patrick D. Mathews et Angelina Angelova. « Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications ». Nanomaterials 10, no 5 (18 mai 2020) : 963. http://dx.doi.org/10.3390/nano10050963.
Texte intégralNakano, Minoru. « Preparation and Structural Investigation of Lipid Nanoparticles with Nonlamellar Phases ». MEMBRANE 31, no 4 (2006) : 202–6. http://dx.doi.org/10.5360/membrane.31.202.
Texte intégralZerkoune, Leïla, Sylviane Lesieur, Jean-Luc Putaux, Luc Choisnard, Annabelle Gèze, Denis Wouessidjewe, Borislav Angelov, Corinne Vebert-Nardin, James Doutch et Angelina Angelova. « Mesoporous self-assembled nanoparticles of biotransesterified cyclodextrins and nonlamellar lipids as carriers of water-insoluble substances ». Soft Matter 12, no 36 (2016) : 7539–50. http://dx.doi.org/10.1039/c6sm00661b.
Texte intégralLeu, Jassica S. L., Jasy J. X. Teoh, Angel L. Q. Ling, Joey Chong, Yan Shan Loo, Intan Diana Mat Azmi, Noor Idayu Zahid, Rajendran J. C. Bose et Thiagarajan Madheswaran. « Recent Advances in the Development of Liquid Crystalline Nanoparticles as Drug Delivery Systems ». Pharmaceutics 15, no 5 (6 mai 2023) : 1421. http://dx.doi.org/10.3390/pharmaceutics15051421.
Texte intégralEleraky, Nermin E., Ayat Allam, Sahar B. Hassan et Mahmoud M. Omar. « Nanomedicine Fight against Antibacterial Resistance : An Overview of the Recent Pharmaceutical Innovations ». Pharmaceutics 12, no 2 (8 février 2020) : 142. http://dx.doi.org/10.3390/pharmaceutics12020142.
Texte intégralNguyễn, Cảnh Hưng, Jean-Luc Putaux, Gianluca Santoni, Sana Tfaili, Sophie Fourmentin, Jean-Baptiste Coty, Luc Choisnard et al. « New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids : Preparation and characterization ». International Journal of Pharmaceutics 531, no 2 (octobre 2017) : 444–56. http://dx.doi.org/10.1016/j.ijpharm.2017.07.007.
Texte intégralVandoolaeghe, Pauline, Justas Barauskas, Markus Johnsson, Fredrik Tiberg et Tommy Nylander. « Interaction between Lamellar (Vesicles) and Nonlamellar Lipid Liquid-Crystalline Nanoparticles as Studied by Time-Resolved Small-Angle X-ray Diffraction† ». Langmuir 25, no 7 (7 avril 2009) : 3999–4008. http://dx.doi.org/10.1021/la802768q.
Texte intégralBarauskas, Justas, Camilla Cervin, Fredrik Tiberg et Markus Johnsson. « Structure of lyotropic self-assembled lipid nonlamellar liquid crystals and their nanoparticles in mixtures of phosphatidyl choline and α-tocopherol (vitamin E) ». Physical Chemistry Chemical Physics 10, no 43 (2008) : 6483. http://dx.doi.org/10.1039/b811251g.
Texte intégralBasañez, Gorka, Juanita C. Sharpe, Jennifer Galanis, Teresa B. Brandt, J. Marie Hardwick et Joshua Zimmerberg. « Bax-type Apoptotic Proteins Porate Pure Lipid Bilayers through a Mechanism Sensitive to Intrinsic Monolayer Curvature ». Journal of Biological Chemistry 277, no 51 (14 octobre 2002) : 49360–65. http://dx.doi.org/10.1074/jbc.m206069200.
Texte intégralBaeza, Isabel, Leopoldo Aguilar, Miguel Ibáñez, Carlos Wong, Francisco Alvarado-Alemán, Carolina Soto, Alejandro Escobar-Gutiérrez, Ricardo Mondragón et Sirenia González. « Identification of phosphatidate nonlamellar phases on liposomes by flow cytometry ». Biochemistry and Cell Biology 73, no 5-6 (1 mai 1995) : 289–97. http://dx.doi.org/10.1139/o95-036.
Texte intégralThèses sur le sujet "Lipid nanoparticles of nonlamellar lipids"
Leesajakul, Warunee. « Preparation and characterization of lipid nanoparticles containing nonlamellar liquid crystalline phases ». 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/145512.
Texte intégralWu, Yu. « Neuroprotective liquid crystalline cubosome and hexosome nanoparticle formulations by self-assembly of plasmalogen lipids and a neurotrophic peptide ». Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ003.
Texte intégralThe primary aim of this thesis is to investigate the neuroprotective effect of plasmalogens (Pls) and explore the potential of lipid nanoparticles against neurodegenerative diseases. Our strategy aims to create a self-assembled system, enhancing the efficacy of plasmalogens and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection. The Pls, a distinctive group of membrane glycerophospholipids, typically contain a polyunsaturated fatty acyl chain at the sn-2 position and an alkyl chain linked by a vinyl-ether bond at the sn-1 position of the glycerol backbone. Pls, with their unique structure featuring a vinyl ether bond, possess free radical scavenging capabilities and antioxidant properties. Addressing the decline in plasmalogen levels in aging individuals holds promise for therapies related to Parkinson's disease, Alzheimer's disease, and dementia. Recent research has expanded our understanding of their antioxidant effects, anti-inflammation, and their involvement in ferroptosis. However, challenges persist in implementing plasmalogens in treatments of neurodegenerative diseases and in developing suitable drug delivery systems. We summarize the progress in lipid nanoparticles (LNPs) for targeting multiple neurodegeneration mechanisms. Our research on plasmalogen-loaded LNPs explores their fabrication mechanism and in vitro/in vivo impacts on neurodegenerative models. Our study shows the feasibility of enhancing Pls efficacy using LNPs as carriers. We employ natural plasmalogens from scallops to create nanoformulations involving a non-lamellar lipid excipient (MO) for structural stabilization, various surfactants, and small amounts of vitamin E, curcumin, or coenzyme Q10. Using small-angle X-ray scattering (SAXS), we identified the structural features of various LNPs (vesicles, cubosomes, and hexosomes). Our in vitro evaluations utilized human neuroblastoma SH-SY5Y cells, differentiated with 10 µM retinoic acid for 5 days. Cell viability tests indicated non-toxicity of the LNPs at a total lipid concentration of 10 µM for 24-hour incubation. We study the impact of Pls nanoparticles on an in vitro model of Parkinson's disease using neuronal cells induced by the neurotoxin 6-OHDA. Using the SH-SY5Y cell line, we explore cellular damage mechanisms (oxidative stress and apoptotic enzymes) via identifying the impact on the ERK-Akt-CREB-BDNF signaling pathway. Several documented neuroprotective compounds were used to demonstrate the ability to restore neuronal lesions caused by 6-OHDA, offering a model of neurodegenerative conditions to further elucidate the beneficial effects of the Pls-based LNPs. We then focus on the cAMP response element binding protein (CREB) and its phosphorylation leading to neurotrophin expression, crucial in preventing neurological disorders. Through lipid peptide nano-assemblies, we studied the impact of different structural organizations of the LNPs on CREB phosphorylation in an in vitro model of Parkinson's disease. Notably, liquid crystalline lipid nanoparticles loaded with plasmalogens prolonged CREB activation under neurodegenerative conditions, showing potential for enhanced neuroregeneration through sustained CREB activation in response to the neurotrophic nanoassemblies. In a mouse model of Parkinson's disease, vesicle and hexosome LNPs demonstrated distinct effectiveness in restoring motor function. The nanomedicine-mediated intervention influenced Parkinson's disease-related gene regulation and rebalanced lipid profiles. Nasal administration of Pls-loaded LNPs improved disease behavioral symptoms and downregulated genes like IL33 and Tnfa. The obtained results indicated the significant impact of hexosomal LNP nanomedicines on disease attenuation, lipid metabolism, and responsive gene modifications potentially involved in regeneration
Kamo, Tomoari. « Lipid membrane structure modulated by nonlamellar-forming lipids and interaction with amphipathic peptide ». 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/137121.
Texte intégralBruzas, Ian R. « Biocompatible noble metal nanoparticle substrates for bioanalytical and biophysical analysis of protein and lipids ». University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1553250462519941.
Texte intégralWa, Kasongo Kasongo. « An investigation into the feasibility of incorporating didanosine into innovative solid lipid nanocarriers ». Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003278.
Texte intégralFuhrer, Andrew B. « The Role of Lipid Domains and Sterol Chemistry in Nanoparticle-Cell Membrane Interactions ». Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1596569401131742.
Texte intégralColomé, Letícia Marques. « Desenvolvimento de nanopartículas inovadoras a partir de constituintes da biodiversidade brasileira destinadas à aplicação tópica de antioxidantes ». reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/143368.
Texte intégralLipid nanoparticles have been developed for administration of active substances to the skin, both for pharmaceutical and cosmetic uses. In the present work, we proposed the first use of a none-refined natural biodegradable and biocompatible lipid – Cupuaçu seed butter (Theobroma grandiflorum) – for the preparation of lipid nanoparticles, which were called theospheres. Theospheres were prepared by emulsification-solvent evaporation (ESE) and by high pressure homogenization technique (HPH), presenting size in nanometrical range and narrow particle size distribution for both methods. Taking these results into account, the next step of this work was the preparation of theospheres by ESE method using Cupuaçu seed butter with or without Brazil nut (Bertholletia excelsa) seed oil - another ingredient derived from an Amazonian fruit - intending the encapsulation of an antioxidant. Idebenone (IDB) has been selected due to its known antioxidant action and because it has been used in antiaging cosmetic formulations. IDB was incorporated in the theospheres presenting encapsulation efficiency higher than 99%. The in vitro release evaluation demonstrated that the release of IDB from theospheres was lower than that of free drug. Besides, the in vitro release study highlighted the elastic characteristics of theospheres. Additionally, IDB-loaded theospheres showed higher antioxidant activity compared to free IDB. Viewing the cutaneous administration, theosphere suspensions prepared by HPH technique were incorporated into hydrogels. The rheograms of the semi-solid formulations exhibited a non-Newtonian behavior presenting pseudoplastic characteristics. In vitro occlusion study highlighted the dependence of the occlusive effect on the lipidic composition of the theospheres. Finally, in vitro human skin permeation studies showed that theospheres and lipid-core nanocapsules, used in this study in a comparative way, changed the permeation of IDB, increasing the accumulative amount of IDB in the upper skin layer.
Haraszti, Reka A. « Engineered Exosomes for Delivery of Therapeutic siRNAs to Neurons ». eScholarship@UMMS, 2018. https://escholarship.umassmed.edu/gsbs_diss/971.
Texte intégralMeanwell, Michael Weiwei. « Synthetic Lipids for Drug Delivery Applications ». Thesis, 2015. http://hdl.handle.net/1828/6714.
Texte intégralGraduate
Kumar, Krishan. « The Role of Liposomal Hybrids and Gold Nanoparticles in the Efficacious Transport of Nucleic Acids and Small Molecular Drugs for Cancer Nanomedicine ». Thesis, 2015. https://etd.iisc.ac.in/handle/2005/3880.
Texte intégralLivres sur le sujet "Lipid nanoparticles of nonlamellar lipids"
Harding, Ian, Rohan Shah, Daniel Eldridge et Enzo Palombo. Lipid Nanoparticles : Production, Characterization and Stability. Springer London, Limited, 2014.
Trouver le texte intégralHarding, Ian, Rohan Shah, Daniel Eldridge et Enzo Palombo. Lipid Nanoparticles : Production, Characterization and Stability : Production, Characterization and Stability. Springer, 2014.
Trouver le texte intégralChapitres de livres sur le sujet "Lipid nanoparticles of nonlamellar lipids"
Hernández-Esquivel, Rosa-Alejandra, Gabriela Navarro-Tovar, Elvia Zárate-Hernández et Patricia Aguirre-Bañuelos. « Solid Lipid Nanoparticles (SLN) ». Dans Nanocomposite Materials for Biomedical and Energy Storage Applications. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102536.
Texte intégralWinter, Roland, et Anne Landwehr. « High-Pressure Effects on the Structure and Phase Behavior of Model Membrane Systems ». Dans High Pressure Effects in Molecular Biophysics and Enzymology. Oxford University Press, 1996. http://dx.doi.org/10.1093/oso/9780195097221.003.0021.
Texte intégralGidwani, Bina, Priya Namdeo, Sakshi Tiwari, Atul Tripathi, Ravindra Kumar Pandey, Shiv Shankar Shukla, Veenu Joshi, Vishal Jain, Suresh Thareja et Amber Vyas. « Lipoidal Carrier as Drug Delivery System ». Dans Nanoparticles and Nanocarriers-Based Pharmaceutical Formulations, 273–302. BENTHAM SCIENCE PUBLISHERS, 2022. http://dx.doi.org/10.2174/9789815049787122010012.
Texte intégralCervantes-Covarrubias, Paola, Ayla Vea-Barragan, Aracely Serrano-Medina, Eugenia Gabriela Carrillo-Cedillo et José Manuel Cornejo-Bravo. « Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments ». Dans Research Anthology on Synthesis, Characterization, and Applications of Nanomaterials, 330–56. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-8591-7.ch015.
Texte intégralCervantes-Covarrubias, Paola, Ayla Vea-Barragan, Aracely Serrano-Medina, Eugenia Gabriela Carrillo-Cedillo et José Manuel Cornejo-Bravo. « Optimizing the Size of Drug-Loaded Nanoparticles Using Design of Experiments ». Dans Design of Experiments for Chemical, Pharmaceutical, Food, and Industrial Applications, 131–57. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-7998-1518-1.ch006.
Texte intégralActes de conférences sur le sujet "Lipid nanoparticles of nonlamellar lipids"
Trapani, Adriana, Delia Mandracchia, Giuseppe Tripodo, Sante Di Gioia, Stefano Castellani, Nicola Cioffi, Nicoletta Ditaranto, Maria Angeles Esteban et Massimo Conese. « Solid lipid nanoparticles made of self-emulsifying lipids for efficient encapsulation of hydrophilic substances ». Dans 15th International Conference on Concentrator Photovoltaic Systems (CPV-15). AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5123565.
Texte intégralReed, Scott M., Min S. Wang et Erica L. Curello. « Electrophoretic Mobility of Lipid Coated Nanoparticles : Understanding the Influence of Size and Charge on a Lipoprotein Particle Mimic ». Dans ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64158.
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