Littérature scientifique sur le sujet « Let-7 miRNA »
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Articles de revues sur le sujet "Let-7 miRNA"
Manier, Salomon, Antonio Sacco, Patricia Maiso, Yong Zhang, Yang Liu, Yosra Aljawai, Weixin Wang et al. « Let-7 Microrna Family Members Regulate Cell Proliferation in Multiple Myeloma ». Blood 120, no 21 (16 novembre 2012) : 570. http://dx.doi.org/10.1182/blood.v120.21.570.570.
Texte intégralFang, W.-J., C.-Z. Lin, H.-H. Zhang, J. Qian, L. Zhong et N. Xu. « Detection of let-7a MicroRNA by Real-time PCR in Colorectal Cancer : a Single-centre Experience from China ». Journal of International Medical Research 35, no 5 (septembre 2007) : 716–23. http://dx.doi.org/10.1177/147323000703500518.
Texte intégralCampbell, Ashley M., Carlos F. De La Cruz-Herrera, Edyta Marcon, Jack Greenblatt et Lori Frappier. « Epstein-Barr Virus BGLF2 commandeers RISC to interfere with cellular miRNA function ». PLOS Pathogens 18, no 1 (10 janvier 2022) : e1010235. http://dx.doi.org/10.1371/journal.ppat.1010235.
Texte intégralPasquinelli, Amy E. « The primary target of let-7 microRNA ». Biochemical Society Transactions 41, no 4 (18 juillet 2013) : 821–24. http://dx.doi.org/10.1042/bst20130020.
Texte intégralRen, Zhiji, et Victor R. Ambros. « Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress ». Proceedings of the National Academy of Sciences 112, no 18 (20 avril 2015) : E2366—E2375. http://dx.doi.org/10.1073/pnas.1422858112.
Texte intégralLiu, Jun, Madeline A. Sauer, Shaza G. Hussein, Junyu Yang, Daniel G. Tenen et Li Chai. « SALL4 and microRNA : The Role of Let-7 ». Genes 12, no 9 (24 août 2021) : 1301. http://dx.doi.org/10.3390/genes12091301.
Texte intégralZhang, Pengcheng, Mallory I. Frederick et Ilka U. Heinemann. « Terminal Uridylyltransferases TUT4/7 Regulate microRNA and mRNA Homeostasis ». Cells 11, no 23 (23 novembre 2022) : 3742. http://dx.doi.org/10.3390/cells11233742.
Texte intégralMedhi, Ragini, Jonathan Price, Giulia Furlan, Beronia Gorges, Alexandra Sapetschnig et Eric A. Miska. « RNA uridyl transferases TUT4/7 differentially regulate miRNA variants depending on the cancer cell type ». RNA 28, no 3 (23 décembre 2021) : 353–70. http://dx.doi.org/10.1261/rna.078976.121.
Texte intégralEmmrich, Stephan, Sarva Keihani, Dirk Reinhardt et Jan-Henning Klusmann. « Members of the Mir-99/100~125 Tricistrons Cooperatively Induce a Pre-Leukemic Myeloproliferative Disorder ». Blood 126, no 23 (3 décembre 2015) : 3579. http://dx.doi.org/10.1182/blood.v126.23.3579.3579.
Texte intégralde Vasconcellos, Jaira F., Colleen Byrnes, Y. Terry Lee, Megha Kaushal, Joshua M. Allwardt, Antoinette Rabel et Jeffery L. Miller. « Targeted Reduction of Let-7a miRNA Increases Fetal Hemoglobin in Human Adult Erythroblasts ». Blood 124, no 21 (6 décembre 2014) : 451. http://dx.doi.org/10.1182/blood.v124.21.451.451.
Texte intégralThèses sur le sujet "Let-7 miRNA"
ORNAGHI, SARA. « Modulazione dell'espressione del miRNA let-7 da parte del nuovo peptide pre-implantation factor : implicazioni per la neuroprotezione in un modello animale di encefalopatia ipossico-ischemica del prematuro ». Doctoral thesis, Universita' Milano Bicocca, 2014. http://hdl.handle.net/10281/193813.
Texte intégralLeppert, Ulrike. « Die Biogenese des COP9 Signalosoms wird durch microRNAs der let-7-Familie reguliert ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16224.
Texte intégralThe COP9 signalosome is a highly conserved protein complex composed of eight subunits. In this study a novel, regulatory mechanism of CSN biogenesis was identified. We used stable transfected siCSN1 cells in which the protein and the mRNA expression of CSN subuntis were downregulated. Transfection of His-CSN1 in those siCSN1 cells led to the induction of the de novo Synthesis of the whole CSN complex. In addition the expression of the transcription factors STAT1 and c-Myc was elevated. The cells were treated with IFN alpha or IFN gamma, respectively. This resulted in the induction of the CSN de novo synthesis. Moreover, the siRNA-mediated inhibition of STAT1, c-Myc, Lin28B as well as treatment with the pharmacological inhibitors AG9 or AG490 led to a reduced protein expression of the analysed CSN subunits. We found that in all experiments there was a significant change on protein level in contrast to a marginal change on the RNA level. Based on our study we hypothesized that the CSN biogenesis ist regulated post-transcriptionally by miRNAs. The participation of miRNAs in the regulation of CSN biogenesis was further analysed. The siCSN1 cells were transfected with complementary hairpin inhibitors of let-7 miRNAs, leading to an induction of the CSN synthesis. The transfection of let-7 miRNA-mimics, which enhance the impact of miRNA on target mRNAs, resulted in an decrease of the CSN expression. These findings prove the involvement of miRNAs in CSN biogenesis, presumably via the c-Myc/Lin28B/let-7 pathway. Furthermore, using miRBase Sanger database and MicroInspector software, potential binding sites for let-7 miRNAs were detected within the mRNA sequences of CSN subunits as well as of subunits of the proteasomal lid. Therefore, there is evidence to suggest that this mechanism is crucial for the regulation of the biogenesis of the proteasomal lid as well.
Nouri, Sirine. « Development of new NMR methods to study miRNA dynamics ». Electronic Thesis or Diss., Lyon 1, 2023. http://www.theses.fr/2023LYO10006.
Texte intégralNon-coding RNAs have appeared in the last decades as central elements of numerous biological processes and understanding how they can perform their function is essential both at the fundamental level and in the perspective of potential applications. Solution- state Nuclear Magnetic Resonance (NMR) methods are a unique way to characterize the structure and dynamics of RNAs and thus shed light on their intrinsic plasticity. This thesis focuses on the development of novel methodologies to describe complex dynamics occurring in RNA with a particular focus on the let-7 micro RNA precursor an interesting system as the deregulation of let-7 can perturb cell development and differentiation and lead to the development of cell-based diseases such as cancer. Due to its size and the flexibility inherent to large RNA loop, the study of the let-7 miRNA precursor remains at the forefront of biological NMR. This work addresses the implementation of an enzymatic production protocol of high concentrated and very pure RNA sample for NMR spectroscopy and the development of new strategies for resonance assignment of RNAs with large non-helical dynamic elements. These methods are used to investigate the structure and dynamics of the let-7 micro RNA precursor. A combination of Small-Angle X-Ray scattering and NMR spectroscopy experimental data (Residual Dipolar Couplings either externally or field-induced) were measured. These experimental data are used in an ensemble optimization method to selectively refine models generated by extensive all-atom molecular dynamics simulations. The selected ensemble is in good agreement with the NMR experimental data. From the structural analysis of the selected ensemble and Chemical Exchange Saturation Transfer experiments, we propose a hypothesis that correlates fast and slow exchange processes happening in the non-helical region of the RNA with its ability to interact with regulatory proteins
Mayr, Florian [Verfasser]. « Structural and Functional Analysis of Lin28-Mediated Inhibition of let-7 miRNA Biogenesis / Florian Mayr ». Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1035182513/34.
Texte intégralWagner, Siegfried [Verfasser]. « Analyses of miRNA let-7 and its targets in canine neoplasias as model for human counterparts / Siegfried Wagner ». Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2015. http://d-nb.info/1070285471/34.
Texte intégralThornton, James Edward. « Roles for Terminal Uridyl Transferases in the Post-Transcriptional Regulation of Developmental miRNAs ». Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11195.
Texte intégralAnene, Chinedu A. « Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells ». Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16041.
Texte intégralFu, Xiaonan. « Functional study of miRNA-mRNA interactions in malaria mosquito An. gambiae ». Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96216.
Texte intégralPHD
Rößling, Rosa [Verfasser]. « Die let-7-miRNA-Familie : Untersuchung ihres Vorkommens in humanem Liquor bei neurodegenerativen Erkrankungen und ihrer neurotoxischen Wirkung in vitro / Rosa Rößling ». Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223928578/34.
Texte intégralKönig, Annekatrin [Verfasser], Halyna [Akademischer Betreuer] Shcherbata, Andreas [Akademischer Betreuer] Wodarz et Jörg [Akademischer Betreuer] Großhans. « Ecdysone signaling and miRNA let-7 cooperate in regulating the differentiation of the germline stem cell progeny / Annekatrin König. Gutachter : Andreas Wodarz ; Jörg Großhans. Betreuer : Halyna Shcherbata ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1070686158/34.
Texte intégralChapitres de livres sur le sujet "Let-7 miRNA"
Skonieczna, Magdalena, Dorota Hudy, Patryk Bil, Malgorzata Adamiec, Marta Stachowska et Krzysztof Biernacki. « Role of Let-7 Family miRNAs in Migration of Colorectal Cancer HCT 116 and Caco-2 Cells After Stimulation by the Adipokine Vaspin. Time-Lapse Live-Cell Microscopic Observations ». Dans Advances in Intelligent Systems and Computing, 47–61. Cham : Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-29885-2_5.
Texte intégralZentilli, Marcos, Milton C. Graves, Ryan Mathur, Jacob J. Hanley, Larry M. Heaman et Ricardo Boric. « Locating the “Missing Half” of the Giant Chuquicamata Porphyry Copper Deposit, Chile ». Dans Tectonomagmatic Influences on Metallogeny and Hydrothermal Ore Deposits : A Tribute to Jeremy P. Richards (Volume I), 69–85. Society of Economic Geologists, 2021. http://dx.doi.org/10.5382/sp.24.05.
Texte intégralActes de conférences sur le sujet "Let-7 miRNA"
Powers, John T., Kaloyan Tsanov, Frederik Roels, Catherine Spina, Richard Ebright, Marc Seligson, Yvanka de Soysa et al. « Abstract LB-165 : Multiple mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-lb-165.
Texte intégralPowers, John T., Kaloyan M. Tsanov, Frederik Roles, Richard Ebright, Marc Seligson, Yvanka de Soysa, Patrick Cahan et al. « Abstract LB-290 : Multiple distinct mechanisms disrupt let-7 miRNA biogenesis and function in neuroblastoma ». Dans Proceedings : AACR 106th Annual Meeting 2015 ; April 18-22, 2015 ; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-lb-290.
Texte intégralHojo, Nozomi, Alyse Huisken, Hanmin Wang, Evgeny Chirshev, Sang Nguyen, Carlotta Glackin, Yevgeniya Ioffe et Juli Unternaehrer. « Abstract 1989 : Mechanism of tumor suppressor miRNA let-7 downregulation in ovarian cancer : The epithelial-mesenchymal transition factor Snail is associated with stemness and represses let-7 ». Dans Proceedings : AACR Annual Meeting 2018 ; April 14-18, 2018 ; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1989.
Texte intégralHuisken, Alyse, Nozomi Hojo, Hanmin Wang, Evgeny Chirshev, Carlotta Glackin, Yevgeniya Ioffe et Julia J. Unternaehrer-Hamm. « Abstract A73 : Mechanism of tumor suppressor miRNA let-7 downregulation in ovarian cancer : The epithelial-mesenchymal transition factor Snail is associated with stemness and represses let-7 ». Dans Abstracts : AACR Special Conference : Addressing Critical Questions in Ovarian Cancer Research and Treatment ; October 1-4, 2017 ; Pittsburgh, PA. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1557-3265.ovca17-a73.
Texte intégralNasreen, Najmunnisa, Nazli Khodayari, Kamal A. Mohammed, Michael Jantz et Eugene P. Goldberg. « EphrinA1 Inhibits Tumor Growth Via Let-7 MiRNA Expression And Repression Of RAS Oncogene In Malignant Mesothelioma ». Dans American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5155.
Texte intégralGeorgiev, Todor, Krasimir Avramov, Aneliya Draganova, Valentin Dichev, Nikolay Mehterov et Kiril Terziyski. « Downregulation of miRNA-125b and let-7 provides a novel aspect to chronic insomnia disorder – a pilot study ». Dans ERS Sleep and Breathing 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/23120541.sleepandbreathing-2023.125.
Texte intégralDalay, Nejat, Zubeyde Yalniz et Orkun Gurbuz. « Abstract A48 : The K-ras let-7 miRNA binding site variant and K-ras mutations in colon cancer ». Dans Abstracts : AACR Special Conference on RAS Oncogenes : From Biology to Therapy ; February 24-27, 2014 ; Lake Buena Vista, FL. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1557-3125.rasonc14-a48.
Texte intégralMenezes, Miriam-Rose, Goeun Bae, Yong Sung Park, Julien Balzeau, Clifford C. Stephan et John P. Hagan. « Abstract 1244 : Anin vitrobiological assay to identify small molecule upregulators of let-7 miRNA in LIN28- positive ovarian cancer cells ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1244.
Texte intégralVIDARD, Laurent, Claire MARIET, Eric BOITIER, Véronique SIERRA, Elisabeth CAVROIS, Carlos GARCIA-ECHEVERRIA et Hélène GOULAOUIC. « Abstract 3550 : Inhibition of either LIN28A or ZCCHC11 (TUT4) provides distinct effects on the expression of the let-7 miRNA family and tumor cell proliferation ». Dans Proceedings : AACR Annual Meeting 2014 ; April 5-9, 2014 ; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3550.
Texte intégralDu, Y., et J. Lu. « Abstract P5-10-15 : Genetic variants located in beta2 adrenergic receptor gene (ADRB2) and miRNA let-7 binding site alter breast cancer susceptibility : a case control analysis ». Dans Abstracts : Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012 ; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p5-10-15.
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