Littérature scientifique sur le sujet « Lc-Hrms2 »
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Articles de revues sur le sujet "Lc-Hrms2"
Fuentes-Monteverde, Juan Carlos, Marvin J. Núñez, Oscar Amaya-Monterosa, Morena L. Martínez, Jaime Rodríguez et Carlos Jiménez. « Multistage Detection of Tetrodotoxin Traces in Diodon hystrix Collected in El Salvador ». Toxins 15, no 7 (25 juin 2023) : 409. http://dx.doi.org/10.3390/toxins15070409.
Texte intégralDandlen, Susana A., José P. Da Silva, Maria Graça Miguel, Amílcar Duarte, Deborah M. Power et Natália Tomás Marques. « Quick Decline and Stem Pitting Citrus tristeza virus Isolates Induce a Distinct Metabolomic Profile and Antioxidant Enzyme Activity in the Phloem Sap of Two Citrus Species ». Plants 12, no 6 (21 mars 2023) : 1394. http://dx.doi.org/10.3390/plants12061394.
Texte intégralYan, Meijia, Chenxue Song, Shiwen Su, Junliang Li, Zhiwei Hu, Sue Lin, Huixi Zou, Zheng Tang et Xiufeng Yan. « Quantification and Diversity Analyses of Glucosinolates in 191 Broccoli Genotypes Highlight Valuable Genetic Resources for Molecular Breeding ». Agronomy 13, no 12 (28 novembre 2023) : 2928. http://dx.doi.org/10.3390/agronomy13122928.
Texte intégralMartins-Noguerol, Raquel, Antonio Javier Moreno-Pérez, Sebastien Acket, Salim Makni, Rafael Garcés, Adrián Troncoso-Ponce, Joaquín J. Salas, Brigitte Thomasset et Enrique Martínez-Force. « Lipidomic Analysis of Plastidial Octanoyltransferase Mutants of Arabidopsis thaliana ». Metabolites 9, no 10 (29 septembre 2019) : 209. http://dx.doi.org/10.3390/metabo9100209.
Texte intégralKučera, Lukáš, Ondřej Kurka, Martin Golec et Petr Bednář. « Study of Tetrahydroxylated Anthraquinones—Potential Tool to Assess Degradation of Anthocyanins Rich Food ». Molecules 26, no 1 (22 décembre 2020) : 2. http://dx.doi.org/10.3390/molecules26010002.
Texte intégralRamiharimanana, Fenia D., Juliano G. Haddad, Maminiaina A. Andrianavalonirina, Cécile Apel, Florent Olivon, Nicolas Diotel, Philippe Desprès, Voahangy Vestalys Ramanandraibe et Chaker El Kalamouni. « Antiviral Effect of Stenocline ericoides DC. and Stenocline inuloides DC., Two Flavonoid-Rich Endemic Plants from Madagascar, against Dengue and Zika Viruses ». Pharmaceuticals 15, no 12 (30 novembre 2022) : 1500. http://dx.doi.org/10.3390/ph15121500.
Texte intégralThèses sur le sujet "Lc-Hrms2"
Cordonnier, Julien. « Toxoplasma gondii : identification par docking inverse sur des cibles moléculaires de composés actifs issus de ressources naturelles ». Electronic Thesis or Diss., Reims, 2024. http://www.theses.fr/2024REIMS001.
Texte intégralTree barks, by-product of forestry industry, constitute an abundant and sustainable source of natural compounds. Toxoplasma gondii is the parasite responsible for toxoplasmosis, posing a threat to fetuses, newborns, and immunocompromised individuals. The current therapeutics, limited and poorly tolerated, are now confronted to chemoresistant phenomena. This doctoral project aims to explore the chemical space associated with tree barks from the Champagne-Ardenne region, as relevant protein targets to fight T. gondii. An initial in silico evaluation using reverse docking (AMIDEv2.0) was carried out to identify biological target for triterpenes derived from betulone, isolated from the European alder, which had exhibited in vitro anti-toxoplasmosis activity. Among 87 proteins of T. gondii, CDPK3 was identified as the most probable target. Subsequently, a bank of 25 essential 3D protein structures for parasite survival, including 19 homology-modeled structures, was compiled. Thereafter, compounds from the Essential National Chemical Library were screened against this protein bank, using AMIDEv2.0. Two proteins were identified as potential targets; one of them was ATG3, a protein structure modeled from homologs with less than 50% identity. Subsequently, the barks of European Larch, whose n-heptane extract had shown significant activity (58% inhibition of parasitic growth at 100 µg/ml), were subjected to a chemical profiling. First, through a fractionation process using Centrifugal Partition Chromatography, and then a dereplication approach combining data from nuclear magnetic resonance and mass spectrometry. Tools like VersaDB and CATHEDRAL were developed to facilitate the creation of custom-databases and assess the confidence level of annotations. 52 molecules were annotated and associated with a confidence score. Simultaneously, in vitro tests demonstrated that 2 out of the 12 CPC fractions, primarily composed of terpenic derivatives, inhibited the parasite's survival by more than 40% at 25 µg/ml. Ultimately, the annotated compounds from L. decidua were subjected to AMIDEv2.0. The overlap between in vitro and in silico results highlighted 7-oxo-dehydroabietic acid and daniellic acid, strongly correlated with the in vitro inhibitory activity of the barks. CDPK1 and the SET-containing Protein are likely protein targets for these two ligands, thereby providing initial insights into their mechanism of action. These two hits are currently undergoing in vitro evaluation to verify the efficiency of developed approach during this doctoral project
Actes de conférences sur le sujet "Lc-Hrms2"
Cordonnier, J., S. Remy, A. Kotland, R. Leroy, A. Martinez, N. Borie, C. Sayagh et al. « Enhancing natural products annotation in dual 13C-NMR and LC-HRMS2 based complex mixtures chemical profiling through custom in silico databases ». Dans GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759205.
Texte intégralCordonnier, J., S. Remy, A. Kotland, R. Leroy, A. Martinez, N. Borie, C. Sayagh et al. « Short Lecture 11 “Enhancing natural products annotation in dual 13C-NMR and LC-HRMS2 based complex mixtures chemical profiling through custom in silico databases” ». Dans GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1758890.
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