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Littérature scientifique sur le sujet « LC-DS »

Auteur : Grafiati

Publié le 10 mars 2023

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Articles de revues sur le sujet "LC-DS"

Nemutlu, Emirhan, Gokcen Orgul, Tuba Recber, Emine Aydin, Ece Ozkan, Mert Turgal, Mehmet Alikasifoglu, Sedef Kir et Mehmet Sinan Beksac. « Metabolic Infrastructure of Pregnant Women With Trisomy 21 Fetuses ; Metabolomic Analysis ». Zeitschrift für Geburtshilfe und Neonatologie 223, n^o 05 (27 mai 2019) : 297–303. http://dx.doi.org/10.1055/a-0877-7869.

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AbstractWe aimed to configure impaired/altered metabolomic profiles of pregnant women carrying Down syndrome (DS) fetuses. The study involved 21 and 32 pregnant women with DS and euploid fetuses, respectively, as determined by prenatal screening and diagnosis as part of an antenatal care program. Metabolomic analyses were carried out using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-qTOF-MS) methods. A total of 95 metabolites were identified. GC-MS analysis indicated that levels of 2-hydroxybutyric acid, benzoic acid, nonanoic acid, 3-hydroxybutyric acid, and 2-ketoisocaproic acid were increased in the DS group, where beta-alanine, threonic acid, oxalic acid, alpha-tocopherol, uracil, 2-piperidone, and creatinine were decreased. However, LC-qTOF-MS analysis showed that lipid-related metabolites were decreased in women carrying DS fetuses, whereas creatine, N4-phosphoagmatine, citrate, 2,5-dioxopentanoate, 2-furoate, pyruvate, and fructose levels were increased. Pathway analysis was also performed using metabolites whose levels were significantly altered (p<0.05) between the groups, and the findings indicated that the biosynthesis pathways of aminoacyl-tRNA and “valine-leucine-isoleucine”, and metabolism pathways of “glycine-serine-threonine”, nitrogen, “alanine-aspartate-glutamate”, propanoate, glycerophospholipid, cysteine, methionine, and phenylalanine were significantly altered. Our findings indicate a special type of metabolic status/syndrome in pregnant women with Down syndrome fetuses. It could be speculated that altered metabolic status might influence both gametogenesis and embryogenesis. Down syndrome is a complex genetic disorder that is important to detect prenatally, but may also be prevented by taking necessary precautions prior to pregnancy.

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Hu, Wei, Ning Liu, Yuhua Tian et Lianxue Zhang. « Molecular Cloning, Expression, Purification, and Functional Characterization of Dammarenediol Synthase fromPanax ginseng ». BioMed Research International 2013 (2013) : 1–7. http://dx.doi.org/10.1155/2013/285740.

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The objective of this study is to clone and charecterize the expression of dammarenediol synthase gene and then to determine the relationship between the expression of dammarenediol synthase gene that is involved in the ginsenoside biosynthetic pathway and the ginsenoside content. A cDNA phage library was constructed from a five-year-old ginseng root. The cDNA library was screened for the dammarenediol synthase gene by using its specific primers. It was further cloned and expressed in pET-30a vector. The recombinant plasmid pET-30a-DS was expressed in RosettaE. coli. The recombinant DS protein was purified by affinity chromatography. The production of dammarenediol was detected by liquid chromatography-mass spectrometry (LC-MS). Results showed that dammarenediol synthase gene was cloned from the cDNA library and was expressed in RosettaE. coliand the SDS-PAGE analysis showed the presence of purified DS protein. LS-MS showed the activity of DS protein, as the protein content increases the dammarenediol increases. Our results indicate that the recombinant dammarenediol synthase protein could increase the production of dammarenediol and the expression of DS played a vital role in the biosynthesis of ginsenosides inP. ginseng.

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Caruel, F., S. Bourguignon, B. Lallement, S. Fargeas, A. DeBussac, K. Harris, G. L. Erickson et J. B. Wahl. « SNECMA Experience With Cost-Effective DS Airfoil Technology Applied Using CM 186 LC® Alloy ». Journal of Engineering for Gas Turbines and Power 120, n^o 1 (1 janvier 1998) : 97–104. http://dx.doi.org/10.1115/1.2818093.

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From a cost point of view SNECMA has found DS columnar grain manufacturing technology to be highly attractive compared to single crystal. CM 186 LC alloy exhibits enhanced mechanical and environmental properties and temperature capability compared to MAR M 200 Hf alloy; these properties are close to first-generation single crystal alloys up to 982°C (1800°F). The alloy is shown to be amenable to various coating and brazing high-temperature processes. The longer term creeprupture/phase stability data base on the alloy has now been extended out to 8300 hours at 1038°C (1900°F). Castings for engine test have been produced using CM 186 LC alloy.

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Rai, R. K., et J. K. Sahu. « Mean-stress and oxidation effects on fatigue behaviour of CM 247 DS LC alloy ». Materials Science and Technology 35, n^o 10 (23 mai 2019) : 1220–26. http://dx.doi.org/10.1080/02670836.2019.1618048.

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Yuan, F. H., Y. S. Yoo, C. Y. Jo, B. G. Choi et Z. Q. Hu. « Surface orientation dependent oxidation behavior of aluminized DS CM 247 LC nickel-base superalloy ». Surface and Coatings Technology 183, n^o 1 (mai 2004) : 106–10. http://dx.doi.org/10.1016/j.surfcoat.2003.09.066.

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Qiang, Fangfang, Zhijin Zhao, Junna Shang et Lei Shen. « Estimation of spreading sequences in LC-DS-CDMA signals based on sparse auto-encoder ». Evolutionary Intelligence 13, n^o 2 (26 septembre 2019) : 235–46. http://dx.doi.org/10.1007/s12065-019-00298-3.

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Tyrtyshnaia, Anna, Sophia Konovalova, Arina Ponomarenko, Anastasia Egoraeva et Igor Manzhulo. « Fatty Acid-Derived N-acylethanolamines Dietary Supplementation Attenuates Neuroinflammation and Cognitive Impairment in LPS Murine Model ». Nutrients 14, n^o 18 (19 septembre 2022) : 3879. http://dx.doi.org/10.3390/nu14183879.

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Neuroinflammation plays a critical role in the pathogenesis of most neurological and neurodegenerative diseases and therefore represents a potential therapeutic target. In this regard, accelerating the resolution process in chronic neuroinflammation may be an effective strategy to deal with the cognitive consequences of neuropathology and generalized inflammatory processes. N-acylethanolamine (NAE) derivatives of fatty acids, being highly active lipid mediators, possess pro-resolving activity in inflammatory processes and are promising agents for the suppression of neuroinflammation and its consequences. This paper is devoted to a study of the effects played by dietary supplement (DS), containing a composition of fatty acid-derived NAEs, obtained from squid Berryteuthis magister, on the hippocampal neuroinflammatory and memory processes. By detecting the production of pro-inflammatory cytokines and glial markers, a pronounced anti-inflammatory activity of DS was demonstrated both in vitro and in vivo. DS administration reversed the LPS-induced reduction in hippocampal neurogenesis and memory deterioration. LC-MS analysis revealed an increase in the production of a range of NAEs with well-documented anti-inflammatory activity in response to the administered lipid composition. To conclude, we found that tested DS suppresses the neuroinflammatory response by reducing glial activation, positively regulates neural progenitor proliferation, and attenuates hippocampal-dependent memory impairment.

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Polo, Giulia, Daniela Gueraldi, Antonella Giuliani, Laura Rubert, Chiara Cazzorla, Leonardo Salviati, Antonio Marzollo, Alessandra Biffi, Alessandro P. Burlina et Alberto B. Burlina. « The combined use of enzyme activity and metabolite assays as a strategy for newborn screening of mucopolysaccharidosis type I ». Clinical Chemistry and Laboratory Medicine (CCLM) 58, n^o 12 (26 novembre 2020) : 2063–72. http://dx.doi.org/10.1515/cclm-2020-0064.

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AbstractObjectivesMucopolysaccharidosis type I (MPS I) was added to our expanded screening panel in 2015. Since then, 127,869 newborns were screened by measuring α-L-iduronidase (IDUA) enzyme activity with liquid chromatography tandem mass spectrometry (LC-MS/MS). High false positives due to frequent pseudodeficiency alleles prompted us to develop a second-tier test to quantify glycosaminoglycan (GAG) levels in dried blood spot (DBS).MethodsHeparan-sulfate (HS) and dermatan-sulfate (DS) were measured with LC-MS/MS after methanolysis. DBSs were incubated with methanolic-HCl 3 N at 65 °C for 45 min. Chromatographic separation used an amide column with a gradient of acetonitrile and water with 10 mM ammonium acetate in a 9-min run. The method was validated for specificity, linearity, lower limit of quantification (LOQ), accuracy and precision.ResultsIntra- and inter-day coefficients of variation were <15% for both metabolites. Reference values in 40 healthy newborns were: HS mean 1.0 mg/L, 0–3.2; DS mean 1.5 mg/L, 0.5–2.7). The two confirmed newborn MPS I patients had elevated HS (4.9–10.4 mg/L, n.v. <3.2) and DS (7.4–8.8 mg/L, n.v. <2.7). Since its introduction in February 2019, the second-tier test reduced the recall rate from 0.046% to 0.006%. Among 127,869 specimens screened, the incidence was 1:63,935 live births. Both patients started enzyme replacement therapy (ERT) within 15 days of birth and one of them received allogenic hematopoietic stem cell transplantation (HSCT) at ht age of 6 months.ConclusionsGAGs in DBS increased the specificity of newborn screening for MPS I by reducing false-positives due to heterozygosity or pseudodeficiency. Early diagnosis and therapeutical approach has improved the outcome of our patients with MPS I.

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Mancini, Ilaria, Guido Domingo, Marcella Bracale, Francesco Loreto et Susanna Pollastri. « Isoprene Emission Influences the Proteomic Profile of Arabidopsis Plants under Well-Watered and Drought-Stress Conditions ». International Journal of Molecular Sciences 23, n^o 7 (30 mars 2022) : 3836. http://dx.doi.org/10.3390/ijms23073836.

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Isoprene is a small lipophilic molecule synthesized in plastids and abundantly released into the atmosphere. Isoprene-emitting plants are better protected against abiotic stresses, but the mechanism of action of isoprene is still under debate. In this study, we compared the physiological responses and proteomic profiles of Arabidopsis which express the isoprene synthase (ISPS) gene and emit isoprene with those of non-emitting plants under both drought-stress (DS) and well-watered (WW) conditions. We aimed to investigate whether isoprene-emitting plants displayed a different proteomic profile that is consistent with the metabolic changes already reported. Only ISPS DS plants were able to maintain the same photosynthesis and fresh weight of WW plants. LC–MS/MS-based proteomic analysis revealed changes in protein abundance that were dependent on the capacity for emitting isoprene in addition to those caused by the DS. The majority of the proteins changed in response to the interaction between DS and isoprene emission. These include proteins that are associated with the activation of secondary metabolisms leading to ABA, trehalose, and proline accumulations. Overall, our proteomic data suggest that isoprene exerts its protective mechanism at different levels: under drought stress, isoprene affects the abundance of chloroplast proteins, confirming a strong direct or indirect antioxidant action and also modulates signaling and hormone pathways, especially those controlling ABA synthesis. Unexpectedly, isoprene also alters membrane trafficking.

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Rai, R. K., J. K. Sahu, A. Pramanick, N. Paulose, DC Fernando et S. K. Das. « Creep deformation micro-mechanisms of CM 247 DS LC Ni-base superalloy under relevant service condition ». Materials Characterization 150 (avril 2019) : 155–65. http://dx.doi.org/10.1016/j.matchar.2019.02.021.

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Thèses sur le sujet "LC-DS"

Pingeon, Marine. « Development and validation of analytical methods for therapeutic drug monitoring ». Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4509.

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2017 - 2018
The U.S. Food and Drug Administration defines as Precision or Personalized Medicine (PM) an innovative therapeutic approach that tailors therapy and prevention on patients based on inter-individual variabilities in molecular or environmental features and in lifestyles. The major goals of PM are to maximize treatment efficacy and to reduce cost, toxicities and therapy failure rates by early identification of patients who might benefit or not of a specific treatment. In this scenario, therapeutic drug monitoring (TDM) is an important laboratory tool for PM because of the possibility to measure several drugs and bioactive molecules in human biological matrices. TDM is based on the hypothesis that in the majority of drugs, there is a relationship between administered dose and circulating concentration of unbound fraction - and between this concentration and observed pharmacological effects. TDM is recommended for drugs with significant inter-individual pharmacokinetic variability and an established relationship between blood concentrations and clinical efficacy and/or toxicity. Moreover, TDM is also advisable in special populations such as pregnant women and children. To date, liquid chromatography and immunometric assay are still considered the standard for molecule measurement in biological fluids; however, in recent years, LC tandem mass spectrometry (LC-MS) is gaining popularity because of the possibility of in-depth and multiplexed analysis with high selectivity and specificity. During this Ph.D. program, we developed several high performance LC (HPLC)- and LC-MS/MS-based approaches for TDM of different drugs measured in various types of body fluids and validated according to EMA and FDA guidelines. In particular, we focused on: 1) TDM of hydroxychloroquine (HCQ) blood concentration, a drug with a wide therapeutic window. Our method was validated on a cohort of patients with Systemic Lupus Erythematosus treated with HCQ and blood concentrations were correlated to several clinical parameters, such quality of life. Moreover, TDM of HCQ was also used to monitor treatment adherence in those subjects. 2) TDM of a commonly used chemotherapeutic agent, the 5-fluorouracil (5-FU), which is known to have a narrow therapeutic window and a high toxicity 3) TDM of a new kinase inhibitor, Ruxolitinib, approved for the treatment of myeloproliferative hematologic disorders. 4) TDM of several drugs, such as caffeine and phenobarbital, in newborns who are at particular risk of uncorrected drug dosage. Due to the need to carry out analyses on very-small volume samples, we validated an analytical method using micro-sampling techniques such as the dried blood spot (DBS) sampling combined with LC-MS/MS analysis. [edited by author]
XVII n.s. (XXXI ciclo)

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Conrado, Marli 1972, Marcos Rivail da 1956 Silva et Universidade Regional de Blumenau Programa de Pós-Graduação em Química. « Validação de metodologia para determinação de cadaverina e putrecina por LC-MS/MS e aplicação em água como indicador de contaminação por necrochorume / ». reponame:Biblioteca Digital de Teses e Dissertações FURB, 2015. http://www.bc.furb.br/docs/DS/2015/360440_1_1.pdf.

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Orientador: Marcos Rivail da Silva.
Co-orientador: Martinho Rau.
Dissertação (Mestrado em Química) - Programa de Pós-Graduação em Química, Centro de Ciências Exatas e Naturais, Universidade Regional de Blumenau, Blumenau.

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Chapitres de livres sur le sujet "LC-DS"

Bayerlein, M., W. Hartnagel et Ch Sommer. « Phenomenological Damage Parameters for TMF Life Prediction of DS CM 247 LC ». Dans Fatigue under Thermal and Mechanical Loading : Mechanisms, Mechanics and Modelling, 109–18. Dordrecht : Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-015-8636-8_12.

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Actes de conférences sur le sujet "LC-DS"

Erickson, G. L., K. Harris et R. E. Schwer. « Directionally Solidified DS CM 247 LC—Optimized Mechanical Properties Resulting From Extensive γ′ Solutioning ». Dans ASME 1985 International Gas Turbine Conference and Exhibit. American Society of Mechanical Engineers, 1985. http://dx.doi.org/10.1115/85-gt-107.

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Complete coarse γ′ and greater than 90% eutectic γ-γ′ solutioning, without incipient melting, is demonstrated for the DS CM 247 LC superalloy. This unusual capability for this advanced Ni-base turbine blade and vane material results in considerable mechanical properties enhancement, with the DS alloy capability being near to current single crystal superalloys in the 345–207 MPa, 871°C–982°C (50–30 ksi, 1600°F–1800°F) operating condition. Microstructural features are detailed correlating strength and alloy stability.

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Caruel, F., S. Bourguignon, B. Lallement, S. Fargeas, A. DeBussac, K. Harris, G. L. Erickson et J. B. Wahl. « SNECMA Experience With Cost Effective DS Airfoil Technology Applied Using CM 186 LC® Alloy ». Dans ASME 1996 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/96-gt-493.

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From a cost point of view SNECMA has found DS columnar grain manufacturing technology to be highly attractive compared to single crystal. CM 186 LC alloy exhibits enhanced mechanical and environmental properties and temperature capability compared to MAR M 200 Hf alloy; these properties are close to first generation single crystal alloys up to 982°C (1800°F). The alloy is shown to be amenable to various coating and brazing high temperature processes. The longer term creep-rupture/phase stability data base on the alloy has now been extended out to 8300 hours at 1038°C (1900°F). Castings for engine test have been produced using CM 186 LC alloy.

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Burkholder, Phil S., Malcolm C. Thomas, Randy Helmink, Donald J. Frasier, Ken Harris et Jacqueline B. Wahl. « CM 186 LC® Alloy Single Crystal Turbine Vanes ». Dans ASME 1999 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/99-gt-379.

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There is a need to introduce advanced turbine technology at reduced cost. SX superalloy vanes demonstrate excellent engine performance and durability benefits compared to their polycrystalline counterparts. However, their manufacturing cost can be prohibitive due to low casting and solution heat treatment yields due to rejectable grain defects. High purity (carbon and boron free), ultra high creep and fatigue strength SX alloys are limited to low angle boundaries (LABs) normally not exceeding 6° in critical airfoil locations. Carbon (C) and boron (B) containing SX superalloys (Ross, et al., 1996) can accommodate low angle boundaries in the 9°–12° range with an overall sacrifice in creep and fatigue properties. Aero engine vane segments with complex configurations, can result in not only LAB defects exceeding 9°–12° but also high angle grain boundary (HAB) defects ≥ 15° occurring during the SX solidification process. This is further excaberated by recrystallised grains occurring during solution heat treatment from residual casting stresses and associated strain. CM 186 LC® is a hafnium (Hf) containing nickel-base superalloy developed for directionally solidified (DS) columnar grain turbine airfoils. SX casting experience — development and production — has shown the alloy can be readily cast into aero turbine multi-airfoil segments. Mechanical property and turbine engine testing show the alloy can accommodate grain boundaries at least up to 30° resulting in high SX casting yields. The SX vane components are either used as-cast or approximately 50% partial solutioned which avoid any recrystallisation (Rx) problems. Component costs can be < 50% of that of a conventional high purity SX alloy. Mechanical property, oxidation and coating performance characterisation studies on SX CM 186 LC (including DS test pieces) and turbine engine test and application experience show a 72°F (40°C) metal temperature capability improvement (thin wall) over DS MAR M 002 alloy.

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Shiunn-Jang Chern, Chun-HungSun et R. H. H. Yang. « Blind fully space-time RAKE DS-CDMA multiuser receiver based on min/max criterion with LC-RLS algorithms ». Dans 2005 International Symposium on Intelligent Signal Processing and Communication Systems. IEEE, 2005. http://dx.doi.org/10.1109/ispacs.2005.1595453.

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Korinko, Paul S., Michael J. Barber et Malcolm Thomas. « Coating Characterization and Evaluation of Directionally Solidified CM 186 LC® and Single Crystal CMSX-4® ». Dans ASME 1996 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/96-gt-426.

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Hot corrosion and long-time dynamic oxidation tests were conducted on several alloy (equiaxed MM-0011 and IN738. SX CMSX-4. and DS CM186LC) and coating (Simple aluminide, Pt-aluminide, and NiCoCrAlY) combinations. The coating performance in both hot corrosion and oxidation testing was, in most cases, influenced by the substrate composition. An overlay NiCoCrAlY on either CMSX-4 or CM186LC appeared unaffected visually, but there were indications during metallographic examination that this coating substrate combination was beginning to degrade after a 1000 hour hot corrosion test. The results of the oxidation test indicated that several of the alloy/coating combinations that were superior in the hot corrosion test were inferior in oxidation. After 6000 hours of dynamic oxidation testing at 1038°C (1900°F) two of the alloy/coating combinations had not yet reached negative weight changes. Metallographic results from the oxidation test show a significant reaction layer in the CMSX-4 coated with either simple or modified aluminides or NiCoCrAlY overlay coatings.

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