Articles de revues : « Lahndā »

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Ponchirolli-Schneider, C. B., J. H. Pryor et C. R. Looney. « 136 IN VITRO DEVELOPMENT OF BOVINE EMBRYOS SUBMITTED TO LASER ASSISTED HATCHING ON DAY 6 AND DAY 7 OF EMBRYO CULTURE ». Reproduction, Fertility and Development 21, n^o 1 (2009) : 168. http://dx.doi.org/10.1071/rdv21n1ab136.

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In vitro production (IVP) of embryos is a valuable tool in bovine assisted reproduction. IVP embryos show lower pregnancy rates when compared to in vivo produced embryos. The inability of the IVP embryo to hatch from the zona pellucida (ZP) after embryo transfer is believed to be one contributing factor. The aim of this study was to compare the ability of IVP embryos to hatch and develop in vitro after being submitted to laser assisted hatching (LAH) at two different time periods of embryo culture: 144 h (Day 6) and 168 h (Day 7). In vitro maturated oocytes from slaughterhouse ovaries (Ovitra Biotechnologies, Amarillo, TX, USA) were fertilized with frozen/thawed semen from two different bulls (Day 0) and cultured in G1.5/G2.5 medium supplemented with 8 mg mL–1 of BSA (Vitrolife, Englewood, CA, USA) at 38.5°C, 5% CO2, 5% O2, 5% N2, in humidified atmosphere. On Day 6 post-fertilization, all viable embryos (n = 251), from three replicates, were washed in holding medium (Vigro Holding Plus, Bioniche, Pullman, WA, USA) and divided into four treatment groups: laser assisted hatching Day 6 and Day 7 (LAHD6 and LAHD7), control Day 6 and Day 7 (CD6 and CD7). The groups LAHD7 and CD7 were immediately placed in G2.5 and returned to the incubator until Day 7. Embryos from groups LAHD6 and CD6 were placed in G2.5 in separate wells of a four well dish and covered with 300 μL of mineral oil. Embryos from LAHD6 group had one third to one half of the external edge of the ZP exposed to a laser beam, using XY Clone® (Hamilton Thorne Biosciences, Inc., Beverly, MA, USA) laser system, with a pulse strength of 90% and a pulse length of 600 μs. The group CD6 was submitted to the same conditions, but did not receive the laser treatment. On Day 7, the experiment was repeated for embryos belonging to groups LAHD7 and CD7. Embryos from all groups were cultured in vitro and evaluated on Day 8 and Day 9 for stage of development. On Day 9, a random sample of embryos from each treatment group (n = 48) was stained with Hoechst 33342 (2.5 μg mL–1) and evaluated under UV light to determine the total number of cells. The number of hatched blastocysts was not different (chi-square, p > 0.05) among the groups on Day 9 of culture (LAHD6 = 49/66, CD6 = 38/61, LAHD7 = 42/59, CD7 = 47/65; 74, 62, 71 and 72%, respectively). However, on Day 8 of culture, LAHD6 showed a higher number (p < 0.05) of hatched blastocysts (40/66, 60%), when compared to group CD6 (26/61, 42%). There was no difference between groups LAHD7 (33/59, 55%) and CD7 (31/65, 47%) on Day 8. Comparison of the total number of cells showed no difference (Student’s t-test, p > 0.05) among the groups (LAHD6 = 154.8 ± 12.2, CD6 = 184.4 ± 19.5, LAHD7 = 170.4 ± 15.8, CD7 = 162.5 ± 14.6), indicating that LAH does not have a detrimental effect on mean cell production throughout embryo development in vitro. These data show that LAH on Day 6 of culture improves in vitro hatching rates on Day 8, while LAH on Day 7 shows no improvement on either Day 8 or 9. Kathy Bradley, Hamilton Thorne Biosciences, Inc.

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Bubenik, Vit. « An Interpretation of Split Ergativity in Indo-Iranian Languages ». Diachronica 6, n^o 2 (1 janvier 1989) : 181–212. http://dx.doi.org/10.1075/dia.6.2.03bub.

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SUMMARY This paper investigates three problems related to the phenomenon of split ergativity in several Indo-Iranian languages. (1) In ergative tenses Pashto and Kashmiri belong to the canonical ergative-absolutive type — irrespective of the definiteness of the nominal P(atient) — while Sindhî and LahndS pattern erga-tively only if P is indefinite. (2) In the case of pronominal arguments the rare antiabsolutive encodes the transitive Subject in ergative tenses and O in non-ergative tenses; the superabsolutive encodes the intransitive S, O in ergative tenses and the transitive S in non-ergative tenses. The Sindhf and Lahnda systems are based on the antiabsolutive without any traces of the superabsolutive. In Section (3) some historical evidence for the antiabsolutive patterning of pronominal clitics in both Middle Indie and Middle Iranian is presented. However, only in Middle Iranian there are some instances of the incipient superabsolutive which are evaluated as an ancestor of the contemporary Pashto superabsolutive (cf. zeyem "I am" and ze=ye vulid=em "he saw me" where the marker of the ergative O = em is a recategorized clitic form of the copula; originally I=his seen=am). RÉSUMÉ Cet article étudie trois problèmes liés au phénomène de l'ergativité partielle en plusieurs langues indo-iraniennes. (1) Aux temps ergatifs, le pachto et le cachemiri appartiennent au type canonique ergatif-absolutif— sans tenir compte de la nature définie-indéfinie du P(atient) nominal — tandis que le sindhi et lahnda appartiennent à ce type-ci seulement en cas du P indéfini. (2) En pachto et en cachemiri, pour les arguments pronominaux le type rare anti-absolutif-hyper-absolutif s'avère en quelques personnes du verbe (deux Ps sont a distinguer, à savoir, l'O(bjet) du predicat transitif aux temps ergatifs, pas aux temps non-ergatifs. L'anti-absolutif encode le S(ujet) transitif aux temps ergatifs et l'O aux temps non-ergatifs; le hyper-absolutif encode le S intransitif, l'O aux temps ergatifs et le S transitif aux temps non-ergatifs. Les systèmes du sindhi et du lahnda sont basés sur l'anti-absolutif sans aucune trace du hyper-absolutif. Dans (3) l'évidence historique pour le comportement antiabsolutif des clitiques pronominaux en moyen indien et iranien est présentée. En moyen iranien uniquement, il y a quelques exemples du hyper-absolutif naissant. Ceux-ci sont considérés comme le devancier du hyper-absolutif en pachto contemporain (cf. ze yem "je suis" et ze-ye vúlid-em "il m'a vu" où le suffixe de l'O ergatif -dm est la forme clitique de la copule récate-gorisée; originellement je=son vu=suis). ZUSAMMENFASSUNG In diesem Aufsatz werden drei Probleme untersucht, die sich auf das Phänomen der gespaltenen Ergativität in einzelnen indo-iranischen Sprachen beziehen. (1) In den ergativen Tempora — ungeachtet der Bestimmtheit des nominalen P(atienten) — gehören Puschtu und Kaschmiri zum kanonischen ergativ-absolutivischen Typus, während Sindhf und Lahnda nur dann, wenn P unbestimmt ist, zu diesem Typus gehören. (2) Im Falle der pronominalen Argumente ergibt sich der seltene antiabsolutiv-superabsolutivische Typus in verschiedenen Personen in Puschtu und Kaschmiri (zwei verschiedene Ps werden unterschieden: das O(bjekt) der transitiven Prädikate in ergativen im Gegensatz zu nicht-ergativen Tempora). Der Antiabsolutiv grammatikalisiert das transitive S(ubjekt) in ergativen und das O in nicht-ergativen Tempora; der Superabsolutiv grammatikalisiert das intransitive S, O in ergativen und das transitive S in nicht-ergativen Tempora. Die Système des Sindhf und Lahnda beruhen auf dem Antiabsolutiv ohne etwaige Spuren des Superabsolutivs auf-zuweisen. In (3) wird der historische Nachweis fur das antiabsolutivische Ver-halten der pronominalen Enklitika im Mittelindischen und Mitteliranischen geführt. Nur das Mitteliranische bietet ein paar Beispiele des in der Ent-wicklung befindlichen Superabsolutivs an, die hier als Vorfahr des Superabsolutivs im heutigen Puschtu beurteilt werden (vgl. ze yem "Ich bin" und ze-ye vúlid-em "er sah mich", wo das Merkmal des ergativen O =am eine rekate-gorisierte klitische Form der Kopula ist; ursprunglich: Ich=sein gesehe-ner=bin).

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Bhatti, Zafar Iqbal, Muhammad Asad Habib et Tamsila Naeem. « Number Marking in English and Thali : A Contrastive Study ». International Journal of English Linguistics 10, n^o 2 (13 février 2020) : 255. http://dx.doi.org/10.5539/ijel.v10n2p255.

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The aim of this paper is to explore the number system in Thali, a variety of Punjabi spoken by natives of Thal desert. There are three number categories singular, dual, and plural but all modern Indo Aryan languages have only singular and plural (Bashir & Kazmi, 2012, p. 119). It is one of the indigenous languages of Pakistan from the Lahnda group as described by Grierson (1819) in his benchmark book Linguistic Survey of India. Layyah is one of the prominent areas of Thal regions. The native speakers of Thali use this sub dialect of Saraiki in their household and professional life. The linguistic boundaries of the present Siraiki belt have changed under different linguistic variational rules as described by Labov (1963), Trudgal (2004), Eckert (2002) and Meryhoff (2008). There are many differences between Thali and Saraiki, on phonological, morphological and orthographical levels. Husain (2017) has pointed out linguistic differences between Saraiki and Lahnda and Thali is one of the popular languages of Lahnda spoken in different parts of Thal regions. According to the local language activists, Thali has been greatly influenced by Saraiki and Punjabi. The lexicon of Thali is composed for 20% of Punjabi, 45% of Saraiki, and 5% of loan words particularly English. Another particularity is that Perso-Arabic characters are used to write Thali. The most distinguishing characteristics of Thali are its parts of speech, word order, case marking, verb conjugation and, finally, usage of grammatical categories in terms of number, person, tense, voice and gender. In this perspective, number marking is the area to focus on noun morphology and exclusively on the recognition of number system in Thali nouns. The analysis of linguistic systems including grammar, lexicon, and phonology provide sound justifications of number marking systems in languages of the world (Chohan & García, 2019).

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Blanchard, Pierre, Jean Bourhis, Benjamin Lacas, Marshall R. Posner, Jan B. Vermorken, Juan J. Cruz Hernandez, Abderrahmane Bourredjem et al. « Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers : An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group ». Journal of Clinical Oncology 31, n^o 23 (10 août 2013) : 2854–60. http://dx.doi.org/10.1200/jco.2012.47.7802.

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Purpose Cisplatin plus fluorouracil (PF) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) in randomized trials in locoregionally advanced head and neck cancers (LAHNCs). The aim of this meta-analysis was to study the efficacy and toxicity of Tax-PF and PF and identify differences in outcomes in subsets of patients. Methods Five randomized trials representing 1,772 patients were identified. Updated individual patient data (IPD) were retrieved for all trials. The log-rank test, stratified by trial, was used for comparison. Interaction or trend tests were used to study the interaction between covariates and treatment. Results Median follow-up was 4.9 years. The hazard ratio (HR) of death was 0.79 (95% CI, 0.70 to 0.89; P < .001; absolute benefit at 5 years: 7.4%) in favor of Tax-PF. Heterogeneity was significant (P = .08, I2 = 51%) and related to one trial. There was no more heterogeneity after exclusion of this trial (P = .99, I2 = 0%), and HR of death was 0.72 (95% CI, 0.63 to 0.83) in favor of Tax-PF. There was no interaction between treatment effect and the following patient covariates: age, sex, performance status, tumor stage, or site. Tax-PF was associated with significant reductions of progression, locoregional failure, and distant failure compared with PF, with HRs of 0.78 (95% CI, 0.69 to 0.87; P < .001), 0.79 (95% CI, 0.66 to 0.94; P = .007), and 0.63 (95% CI, 0.45 to 0.89; P = .009) respectively. Conclusion This IPD meta-analysis shows the superiority of Tax-PF over PF as induction chemotherapy. Its precise role in the management of LAHNC remains to be determined.

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KÜÇÜKZOROĞLU, Merve. « Basra ve Kûfe Dil Ekollerinin Semâʻ Özelinde İhtilaflarının Örneklerle İzahı ». Düzce İlahiyat Dergisi 7, n^o 1 (30 juin 2023) : 33–59. http://dx.doi.org/10.61272/duid.1321209.

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İslâm dünyasında fetih hareketlerinin artmasıyla Arap olmayan milletler Araplarla bir arada yaşamaya başlamış, Arapça’ya olan yönelim artmış, bunun neticesinde dilde bozulmalar meydana gelmiştir. Lahn denilen bu bozulmalar, dînî nasların yanlış anlaşılması da dâhil birçok hataya sebebiyet vermiştir. Lahnin önüne geçmek için gramer kurallarının tespiti zorunlu hale gelerek bu hususta ilk çalışmalar Basra’da yapılmıştır. O dönemde Kûfe’de çeşitli alanlarda ilmi faaliyetlerin yürütülüyor olması sebebiyle Kûfe âlimlerinin, dil çalışmalarına daha sonra dâhil olduğu söylenmiştir. Yaşanılan bölgelerin coğrafi konumu, buralardaki siyasi ve sosyal durumlar ve yöntem farklılıkları Kûfe ve Basra’nın iki ayrı ekol olmasında etken sebepler olmuştur. Nahiv kaideleri ortaya konulurken her iki ekol de semâʻ, kıyâs, icmâʻ gibi metotları kullanmışlar, ancak bu metotları kullanma bakımından farklılık göstermişlerdir. Aynı şekilde çalışmamızın ana konusunu teşkil eden semâʻda başvurulan kaynaklar hususunda da birbirlerinden ayrılmışlardır. Basra ekolünün bu kaynakların kullanımında tavizsiz, katı bir tutum sergilediği söylenirken Kûfe ekolünün bir miktar daha müsamahakâr davrandığı belirtilmiştir. Nitekim nahiv kurallarının oluşturulmasında esas alınan tüm yöntemlerin çıkış noktası olan semâʻda takınılan tavrın diğer metotların kullanımında da tesiri olmuştur. Söz konusu metot hakkında gerek Arapça gerek Türkçe çalışmaların yapıldığı görülmüştür. Araştırmamızda ekollerin semâʻ özelinde ihtilafa düştükleri noktalar, örnekler vasıtasıyla müşahhas bir hale getirilecektir. Çalışmamızda semâʻdan ana hatlarıyla bahsedilerek müracaat edilen kaynaklar, Basra ve Kûfe ekollerinin farklı yaklaşımlarıyla birlikte ele alınacaktır. Çalışmamızı özgün kılacak nokta ise ekollerin semâʻ metodunda ihtilafa düştükleri meselelerin örnekler üzerinden izah edilecek olmasıdır. Böylelikle ihtilaf noktaları teoriden pratiğe dökülerek somutlaştırılmaya çalışılacaktır.

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Pimvichai, Sirinya, Yaowarat Matchim, Tanadej Sinthusake et Kiratiya Wongkalasin. « Quality of life and its correlates in pretreatment patients with locally advanced head and neck cancer : A cross-sectional study in Thailand ». Belitung Nursing Journal 9, n^o 3 (26 juin 2023) : 244–52. http://dx.doi.org/10.33546/bnj.2621.

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Background: Locally advanced head and neck cancer (LAHNC) can significantly impact the quality of life of patients in various ways. However, several factors can contribute to the decrease in quality of life. In Thailand, there is limited knowledge about the factors that affect the quality of life of patients with LAHNC before they receive treatment. Objective: This study aimed to examine the correlations between Palliative Performance Scale (PPS), family income, body mass index (BMI), age, comorbidity index, and the quality of life of patients with LAHNC before they undergo treatment. Methods: A correlational cross-sectional study was conducted, and data were collected from 94 pretreatment patients with LAHNC who were admitted to a cancer center in central Thailand using purposive sampling. The data collection instruments included a demographic data form, a medical record form, the Charlson Comorbidity Index (CCI), the Palliative Performance Scale (PPS), and the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) version 4. Descriptive statistics, Pearson’s correlation, and Spearman’s rank correlation were used to analyze the data. Results: All study participants completed the questionnaire. The results showed that the overall quality of life of the patients was moderate. PPS, family income, and body mass index were moderately positively correlated with quality of life (r = 0.494, p <0.01; r = 0.420, p <0.01; r = 0.339, p<0.01, respectively). Age had a moderate negative correlation with quality of life (r = -0.596, p <0.01), while comorbidity was not significantly associated with quality of life. Conclusion: The quality of life of patients with LAHNC before treatment was associated with various factors, including PPS, family income, body mass index, and age. These findings highlight the importance of nutritional support before treatment and the need for social support, especially for older adult patients, to improve their quality of life. The results of this study can be valuable for nurses in developing care programs that enhance the quality of life for patients with LAHNC during the pretreatment phase.

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MOHAMMAD SHAM MOHAMMAD et MOSLI TARSAT. « SEJARAH ASAL USUL IRANUN DAN BALANGINGI DI TUNGKU, 1840-1879 ». Jurnal Borneo Arkhailogia (Heritage, Archaeology and History) 7, n^o 1 (21 décembre 2022) : 178–88. http://dx.doi.org/10.51200/jba.v7i1.4215.

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Artikel ini mengupas tentang sejarah asal usul Iranun dan Balangingi di kawasan Tungku, Lahad Datu. Kedua-dua suku kaum ini merupakan antara suku kaum yang sebahagian besarnya terlibat dengan aktiviti ekonomi berasaskan kelautan. Terdapat juga sebahagian suku kaum ini yang terlibat dalam menjalankan aktiviti kegiatan pelanunan di kawasan Asia Tenggara. Kegiatan pelanunan telah dikaitkan dengan suku kaum ini disebabkan kemahiran pelayaran. Budaya cara hidup suku kaum ini khususnya yang menjalankan aktiviti pelanunan dan penculikan hamba di sepanjang perairan Kepulauan Borneo telah menyebabkan mereka telah ditakuti oleh para pelayar. Kajian ini menggunakan metode kualitatif iaitu temu bual selain sumber rujukan dan akhbar dan buku. Hasil kajian awal mendapati kedudukan geografi menjadi salah satu pemangkin kehadiran mereka di kawasan Tungku, Lahad Datu. The paper discusses about Iranun and Balangingi are sea tribes that carry out marine economic activities, especially fishing activities in Southeast Asia. Piracy activities have been associated with this tribe due to their sailing skills, especially in searching for slaves. The way of life of this tribe has become a culture to carry out fishing activities along this area of the Borneo archipelago. Records of these two races were found in Tungku, Lahad Datu due to its close geographical position in the Sulu archipelago. There are two main seas that surround the area of Tungku, Lahad Datu, namely the Sulu and Sulawesi seas. This study uses qualitative methods which are interviews, newspapers and books. This study was conducted to highlight the origins of Iranun and Balangingi in Tungku, Lahad Datu. The results of the preliminary study found that the geographical position was one of the catalysts for their presence in the Tungku area, Lahad Datu. The importance of this study is to detect the existence of Iranun and Balangingi in the area of Teluk Darvel which is Tungku. Tungku was the main settlement area that was carried out as a trade link during the era of Syarif Usman, Teluk Marudu.

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Mikulski, Dimitri V. « South Yemeni Historian Ahmad Fadl al-‘Abdali (1881–1943) on His Native Land (Based on the Historical Work Hadiyyat al-Zaman fi Akhbar muluk Lahdj wa ‘Adan) ». Oriental Courier, n^o 3-4 (2021) : 138. http://dx.doi.org/10.18254/s268684310018002-0.

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Ahmad Fadl al-‘Abdali (1881–1943) is a remarkable cultural figure of Southern Yemen. A close relative of the sovereigns of Sultanate of Lahdj, he displayed himself as a poet, a musician, a horticulturist, a general, a politician and, finally, a historian. While describing his native Lahdj and Aden, ruled by the British, in the historical work of Hadiyyat al-Zaman fi Akhbar muluk Lahdj wa ‘Adan al-‘Abdali revealed himself as a genuine adherent of the traditional Arabic school of history-writing, who nevertheless acquired some “alien” lessons and innovations. While telling the story of Ahmad Fadl al-‘Ablali and his work on history, the Author of the article puts his study into a broad historical framework, besides sharing with the reader his own impressions on the visit to Southern Yemen undertaken in 1982.

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Malik, Ahmed Abdul, Muhammad Khairi Bin Mahyuddin, Najib Sheikh Abdisamad et Mikail Ibrahim. « An Islamic Model of Conflict Management and Conflict Resolution : Lahad Datu in Sabah as a Case Study ». Mediterranean Journal of Social Sciences 9, n^o 3 (1 mai 2018) : 143–50. http://dx.doi.org/10.2478/mjss-2018-0056.

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Abstract Conflict is an inevitable part of human life. In any situation involving more than one person, conflict can arise. The causes of conflict range from philosophical differences and divergent goals, to power imbalances. When conflict arises, it is easy for people to be stubborn and remain entrenched in their positions and for tempers to flare, voices to rise and body language to become defensive or aggressive. Conflict is an unexpected inconvenience. This can be proved by the Lahad Datu Sabah conflict which occurred in 2013, where armed men landed in Lahad Datu to enforce an ancestral land claim. During the conflict, 12 security police were killed and some of them were mutilated. A week-long impasse in a coastal village ended in bloodshed, as a Malaysian ground assault gave way to air strikes. The aims of this research is to analyze the issues of Lahad Datu, to examine the strategies that can be used to promote peace and stability and to introduce an Islamic model of conflict resolution. A self-constructed survey instrument was distributed to 236 residents of Lahad Datu, who voluntarily participated in the study. The results indicated that a level of awareness and a resolution of conflict effects peoples’ reaction towards a government’s response to invaders, their perceptions about the causes of the conflict and their stance during a conflict. Furthermore, the study found that gender, religion, education, occupation and marital status had no effect on the dependent variables. Finally, the findings of the research disclosed that an Islamic model of conflict resolution can be used to resolve the conflict of Lahad Datu or similar social conflicts.

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Ambikapathy, Manimegalai, et Hasmah Zanuddin. « “Gatekeeper or Crisis Manager ? Coverage of "Lahad Datu" Conflict” ». International Journal of Engineering & ; Technology 7, n^o 3.21 (8 août 2018) : 476. http://dx.doi.org/10.14419/ijet.v7i3.21.17217.

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Lahad Datu conflict also known as “Sabah standoff” conflict, is unforgettable tragedies until killed about 10 of Malaysian security personnel and impacted economic, social and emotion of citizens especially at Lahad Datu, Sabah. The objective of this research is to examine the portrayal of solution from Malaysian Government for the “Lahad Datu Crisis” through newspaper framing in Malaysian mainstream newspapers namely Utusan Malaysia, The Star, Sin Chew and Nanban daily. The measurement for the crisis response will be measure through few independent variables such as category of “Lahad Datu” news; between problem, solution, people or neutral category. The following independent variable is through the slants of news; whether news is slanted in positive, negative or neutral slant. With the assistance of “Situational Crisis Communication Theory”, this research employed a systematic quantitative content analysis to gather the data. Finding revealed that, category of solution appeared most in Utusan Malaysia, The Star, Sin Chew and Nanban daily and news in positive slants were covered in all the selected dailies. In providing responses for the crisis, Justification and Concern crisis response portrayed most, however, through Kruskal Wallis test, data found that The Star and Utusan Malaysia portrayed most of the Justification and Concern responses compare to Sin Chew daily and Nanban daily.

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Roubet, C. « Koudiat Kifen Lahda ». Encyclopédie berbère, n^o 28-29 (1 janvier 2008) : 4271–82. http://dx.doi.org/10.4000/encyclopedieberbere.120.

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ÇELİK, Ahmet. « Hurma Çiftçi Lahdi ». PHASELIS, n^o 5 (24 septembre 2019) : 231–49. http://dx.doi.org/10.18367/pha.19015.

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Johnson-Buarque, E. J. « Phase I/II trial of induction chemotherapy in locally advanced head and neck carcinoma (LAHNC) and recurrent disease (RD) after surgery/radiotherapy with weekly docetaxel (D), tomudex (T) and cisplatin (P)—DTP ». Journal of Clinical Oncology 24, n^o 18_suppl (20 juin 2006) : 15536. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.15536.

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15536 Background: The role of neoadjuvant chemotherapy in LAHNC and treatment for RD have not been established yet. Infusional 5-FU combination with DP is one of the most active regimens for patients (pts) with LAHNC, at the same time is very toxic (hematological, gastrointestinal (GI) and cardiovascular). In order to reduce its toxicity we designed a novel weekly triple-drug scheme trying to reduce toxicity and mantain the high response rate. Methods: LAHNC and RD pts received D 35/mg/m2, T 1 mg/m2 and P 25 mg/m2 on days 1, 8 and 15. with one week rest. Some pts received only days 1 and 8 due to hematological toxicity (grade 2, 3 or 4). Planned treatment included 3 through 6 cycles (50% pts received 3 cycles). After neoadjuvant chemotherapy, pts with LAHNC were sent to their doctors to continue the treatment according to their own preference (surgery, RXT or RXT/QT). Results: Between november 2001 and may 2004, 24 pts (M = 17 F = 7) median age 61 (range 45–72) have been enrolled. 17 was LAHNC and 7 RD; tumor sites were: oral cavity 18 and oropharinx/larinx 6 pts. Response rate (RECIST) and toxicity (NCI) were avaible to all pts. 37.5% pts had grade 3/4 toxicity (hematological or GI) and these pts had a dose reduction. There was one febrile neutropenia and no deaths. The overall rate response was 91.6% (3 CR and 19 PR) in all sites of disease including lymphonodes. Conclusions: This scheme DTP has a high respose rate with low and manageable toxicity. It will be necessary to compare it with concurrent radiotherapy + dose reduction chemotherapy with or without cetuximab. No significant financial relationships to disclose.

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Driessen, Chantal M., Janneke C. Ham, Maroeska te Loo, Esther van Meerten, Maurits van Lamoen, Marina H. Hakobjan, Robert P. Takes et al. « Genetic Variants as Predictive Markers for Ototoxicity and Nephrotoxicity in Patients with Locally Advanced Head and Neck Cancer Treated with Cisplatin-Containing Chemoradiotherapy (The PRONE Study) ». Cancers 11, n^o 4 (17 avril 2019) : 551. http://dx.doi.org/10.3390/cancers11040551.

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Ototoxicity and nephrotoxicity are potentially irreversible side effects of chemoradiotherapy with cisplatin in locally advanced head and neck cancer (LAHNC) patients. Several predictive genetic variants have been described, but as yet none in LAHNC patients. The aim of this study is to investigate genetic variants as predictors for ototoxicity and nephrotoxicity in LAHNC patients treated with cisplatin-containing chemoradiotherapy. Our prospective cohort of 92 patients was genotyped for 10 genetic variants and evaluated for their association with cisplatin-induced ototoxicity (ACYP2, COMT, TPMT and WFS1) and nephrotoxicity (OCT2, MATE and XPD). Ototoxicity was determined by patient-reported complaints as well as tone audiometrical assessments. Nephrotoxicity was defined as a decrease of ≥25% in creatinine clearance during treatment compared to baseline. A significant association was observed between carriership of the A allele for rs1872328 in the ACYP2 gene and cisplatin-induced clinically determined ototoxicity (p = 0.019), and not for ototoxicity measured by tone audiometrical assessments (p = 0.449). Carriership of a T allele for rs316019 in the OCT2 gene was significantly associated with nephrotoxicity at any time during chemoradiotherapy (p = 0.022), but not with nephrotoxicity at the end of the chemoradiotherapy. In conclusion, we showed prospectively that in LAHNC patients genetic variants in ACYP2 are significantly associated with clinically determined ototoxicity. Validation studies are necessary to prove the added value for individualized treatments plans in these patients.

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Cholleng, Norsariha, et Aliza Binti Alias. « Halangan Utama Guru Pendidikan Khas Menjalankan Pengajaran Dalam Talian Sewaktu Perintah Kawalan Pergerakan (PKP) ». Malaysian Journal of Social Sciences and Humanities (MJSSH) 7, n^o 5 (25 mai 2022) : e001530. http://dx.doi.org/10.47405/mjssh.v7i5.1530.

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Kajian ini dijalankan bagi mengenal pasti halangan utama yang dihadapi dalam kalangan Guru Pendidikan Khas (GPK) sepanjang menjalankan pengajaran dalam talian sewaktu Perintah Kawalan Pergerakan (PKP) di Daerah Lahad Datu. Seramai 54 orang GPK yang mengajar di sekolah yang mempunyai Program Pendidikan Khas Integrasi di Lahad Datu telah terlibat dalam kajian ini. Instrumen kajian iaitu soal selidik telah disebarkan secara atas talian dalam bentuk “Google Form” dan data dianalisis secara statistik deskriptif dengan menggunakan perisian Statistical Package for Social Science (SPSS) Versi 26.0. Dapatan kajian mendapati halangan utama yang dihadapi oleh guru adalah sikap pelajar ketika mengikuti sesi pembelajaran dalam talian dengan perolehan data sebanyak 37 peratus bersamaan dengan 20 orang guru (37%), diikuti oleh ketiadaan rangkaian telefon sebanyak (33.3%) 18 orang guru. Kesimpulannya pihak yang berkaitan haruslah meneliti halangan yang dihadapi dalam kalangan Guru Pendidikan Khas di Lahad Datu dan mencari jalan penyelesaian untuk mengurangkan serta menyelesaikan masalah yang dihadapi agar sistem pendidikan pada masa PKP dapat di ditambah baik selaras dengan konsep pendidikan sepanjang hayat.

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Lu, Hsueh-Ju, Chao-Chun Yang, Ling-Wei Wang, Pen-Yuan Chu, Shyh-Kuan Tai, Ming-Huang Chen, Muh-Hwa Yang et Peter Mu-Hsin Chang. « Modified Weekly Cisplatin-Based Chemotherapy Is Acceptable in Postoperative Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer ». BioMed Research International 2015 (2015) : 1–7. http://dx.doi.org/10.1155/2015/307576.

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Background. Triweekly cisplatin-based postoperative concurrent chemoradiotherapy (CCRT) has high intolerance and toxicities in locally advanced head and neck cancer (LAHNC). We evaluated the effect of a modified weekly cisplatin-based chemotherapy in postoperative CCRT.Methods. A total of 117 patients with LAHNC were enrolled between December 2007 and December 2012. Survival, compliance/adverse events, and independent prognostic factors were analyzed.Results. Median follow-up time was 30.0 (3.1–73.0) months. Most patients completed the entire course of postoperative CCRT (radiotherapy ≥ 60 Gy, 94.9%; ≥6 times weekly chemotherapy, 75.2%). Only 17.1% patients required hospital admission. The most common adverse effect was grade 3/4 mucositis (28.2%). No patient died due to protocol-related adverse effects. Multivariate analysis revealed the following independent prognostic factors: oropharyngeal cancer, extracapsular spread, and total radiation dose. Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively.Conclusion. Modified weekly cisplatin-based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.

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Mutalik, Chinmaya, Di-Yan Wang, Dyah Ika Krisnawati, Achmad Jazidie, Sibidou Yougbare et Tsung-Rong Kuo. « Light-Activated Heterostructured Nanomaterials for Antibacterial Applications ». Nanomaterials 10, n^o 4 (30 mars 2020) : 643. http://dx.doi.org/10.3390/nano10040643.

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An outbreak of a bacterial contagion is a critical threat for human health worldwide. Recently, light-activated heterostructured nanomaterials (LAHNs) have shown potential as antibacterial agents, owing to their unique structural and optical properties. Many investigations have revealed that heterostructured nanomaterials are potential antibacterial agents under light irradiation. In this review, we summarize recent developments of light-activated antibacterial agents using heterostructured nanomaterials and specifically categorized those agents based on their various light harvesters. The detailed antibacterial mechanisms are also addressed. With the achievements of LAHNs as antibacterial agents, we further discuss the challenges and opportunities for their future clinical applications.

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Baxi, Shrujal S., Eric Jeffrey Sherman, Coral L. Atoria, Nancy Y. Lee, David G. Pfister et Elena B. Elkin. « Impact of cetuximab on chemoradiation use in older patients with locally advanced head and neck cancer. » Journal of Clinical Oncology 31, n^o 15_suppl (20 mai 2013) : 6594. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.6594.

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6594 Background: The benefit of chemoradiation (CTRT) in the treatment of locally advanced head and neck cancer (LAHNC) declines in older and sicker patients. In 2006, the FDA approved cetuximab in LAHNC. Cetuximab with radiation has a perceived lower side effect profile compared to standard chemotherapies used in CTRT. Our objective was to examine the impact of cetuximab on the use of CTRT in elderly patients with LAHNC. Methods: We identified adults aged 66 and older diagnosed with LAHNC between 1999 and 2007 in the Surveillance Epidemiology and End Results (SEER)-Medicare linked database. Treatment was categorized as CTRT or other based on Medicare claims within 6 months of diagnosis. We excluded patients who did not receive definitive treatment. In patients who had CTRT, we identified use of cetuximab based on drug-specific billing codes. We assessed trends in the use of CTRT over the entire study period and in the use of cetuximab since 2006. We examined the influence of age and comorbidity on the likelihood of receiving CTRT before and after 2006 adjusting for clinical and demographic factors. Results: We identified 4,809 patients with LAHNC. One-fourth were ≥80 years and almost a fifth had a Charlson comorbidity score (CCS) of ≥2. Overall more than 20% of patients received CTRT. The use of CTRT more than tripled over time, from 10% of patients diagnosed in 1999 to 38% in 2007 (p<0.0001 for trend). Of the 336 patients who had CTRT since 2006, 45% received cetuximab. Prior to 2006, patients ≥80 years or those with a CCS of ≥2 were significantly less likely to be treated with CTRT compared to younger patients or those with a CCS of 0. In patients diagnosed in 2006 or later, age and comorbidity no longer predicted the likelihood of receiving CTRT. Conclusions: In this population-based cohort of older adults, the use of CTRT increased substantially over time. The availability of cetuximab, with a perceived gentler side effect profile, may have increased the use of CTRT, especially in older and sicker patients. [Table: see text]

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Choudhary, Megha, Veenita Yogi, Sachet Saxena, Vidhi Gupta, Om P. Singh, Suresh Yadav et Rishika Saxena. « Comparison of Thyroid Toxicity Profiles in Head and Neck Cancer Patients Irradiated by 3D-Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy ». Medical Journal of Dr. D.Y. Patil Vidyapeeth 17, n^o 2 (mars 2024) : 404–10. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_879_22.

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ABSTRACT Background: In spite of recent technical advances in the radiation field, exposure to non-target organs such as the thyroid gland remains unavoidable in locally advanced head and neck cancer (LAHNC) planning, which is associated with late toxicities, and this may affect the lifestyle of cancer survivors. Aim: The purpose of this study was to estimate the incidence of thyroid toxicity in LAHNC patients treated with three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT). To establish its correlation, we have analyzed thyroid profile levels, DVH, and the doses of radiation received by the thyroid volume in both radiotherapy planning methods. Material and Method: Sixty patients with LAHNC enrolled and were divided into two groups treated with 3D-CRT (group A) and IMRT (group B). The patient’s thyroid function test, which consisted of serumT3, T4, and TSH, was done before starting radiotherapy and at 6 months and 12 months follow-up. Absolute thyroid volume, maximum dose, minimum dose, mean dose to the thyroid gland, and percentage of thyroid volume receiving as V10, V20, V30, V40, and V50 were studied. Results: After 6-month post-RT, 6.7% of patients in group A showed biochemical hypothyroidism, whereas biochemical hypothyroidism, sub-clinical hypothyroidism, and hyperthyroidism were observed in 10%, 3.3%, and 10% patients of group B, respectively. After 12 months post-RT, 23.3% of patients in group A showed hypothyroidism. In the 3DCRT group, mean T3 was significantly higher for patients with no hypothyroidism (P < 0.05). Mean T4 was observed to be significantly lower in both the groups in hypothyroid patients (P < 0.05). Mean TSH was significantly higher for hypothyroid patients in the IMRT group (P > 0.01). The difference in thyroid volume and thyroid dose was observed to be statistically significant (P < 0.05). Conclusion: The incidence of thyroid toxicity may be decreased by sparing the volume of the thyroid gland and the thyroid dose kept to a minimum. As per dosimetric parameters, >V40 may predict the risk of developing hypothyroidism after irradiation in LAHNC patients. We recommend regular thyroid function tests on follow-up visits of irradiated patients of LAHNC.

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Rumokoy, Laurentius J. M., Constatyn Sumolang, Ivonne Maria Untu et Wisje Lusia Toar. « KERAGAMAN SERANGGA PADA BUDIDAYA Brachiaria mutica DAN POTENSI REVITALISASI LAHAN DI BAWAH KANOPI KELAPA ». Pastura 10, n^o 2 (19 avril 2021) : 74. http://dx.doi.org/10.24843/pastura.2021.v10.i02.p03.

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Penelitian observasi ini bertujuan untuk mencari tahu kondisi lahan kelapa yang berpotensi direvitalisasi.Secara simultan penelitian ini memiliki tujuan lain untuk mencari tahu keragaman serangga di lokasi budidayaBrachiaria mutica di bawah kanopi pohon kelapa. Metode yang digunakan dalam studi ini terbagi dalam duatahap, pertama observasi keragaman serangga dilakukan pada lokasi budidaya B. mutica di bawah kanopikelapa dilakukan di Sentrum Agraris Lotta (SAL), tahap kedua adalah survei lapangan menyangkut levelkualitas lahan di bawah areal tanaman kelapa di daerah perbatasan Manado dan Minahasa Utara. Hasilpenelitian menunjukkan bahwa ada enam ordo dan 10 famili serangga dengan indeks keragaman sebesar0,323 SWI dengan pola interaksi positif antara serangga-serangga dengan B. mutica yang ditanam di bawah tanaman kelapa. Tedapat 37,5% lahan kelapa yang tergolong Q3. Kondisi kualitas lahan terbanyak pada level Q3 dan Q2 menunjukkan bahwa upaya revitalisasi dibutuhkan untuk dapat memaksimumkan lahandi bawah kanopi kelapa. Dengan demikian dapat disimpulkan bahwa upaya revitalisasi pemanfaatan lahandi bawah kanopi tanaman kelapa perlu dilakukan dengan mempertimbangkan berbagai kondisi lahan danperanan serangga yang berinteraksi dengan tanaman budidaya tersebut.Kata kunci interaksi serangga, Brachiaria mutica, revitalisasi, lahan kelapa

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Mustaffa, Normah, et Faridah Ibrahim. « Pembingkaian Visual Berita Krisis Lahad Datu (Visual Framing of Lahad Datu’s Crisis News) ». Jurnal Komunikasi, Malaysian Journal of Communication 34, n^o 1 (28 mars 2018) : 170–84. http://dx.doi.org/10.17576/jkmjc-2018-3401-10.

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Sudin, Mapatan, Md Noor Saper et Nor Sayyidatina Che Rozubi. « Kajian Tinjauan Buli Siber dalam kalangan Remaja Tingkatan Dua di Daerah Lahad Datu, Sabah ». Malaysian Journal of Social Sciences and Humanities (MJSSH) 7, n^o 8 (27 août 2022) : e001728. http://dx.doi.org/10.47405/mjssh.v7i8.1728.

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Kajian ini bertujuan untuk meninjau tentang kegiatan buli siber dalam kalangan remaja tingkatan dua di sekolah menengah di Daerah Lahad Datu, Sabah. Skop kajian tinjauan yang dikaji antaranya ialah mengenal pasti jumlah masa yang digunakan oleh remaja dalam melayari internet, tujuan melayari internet dan kekerapan remaja menjadi mangsa buli siber. Kajian ini menggunakan pendekatan kuantitatif melalui kaedah kajian tinjauan terhadap 166 remaja tingkatan dua di sekolah menengah di Daerah Lahad Datu Sabah. Data kajian diperolehi menggunakan instrumen soal selidik yang mengandungi aspek demografi, jumlah masa yang digunakan untuk melayari internet, tujuan melayari internet dan kekerapan menjadi mangsa buli siber. Data dianalisis menggunakan Statistical Package for Social Science (SPSS) versi 21.0. Dapatan kajian menunjukkan jumlah masa yang digunakan melayari internet dalam kalangan remaja tingkatan dua di Daerah Lahad Datu Sabah ialah 3 jam hingga 5 jam sehari iaitu 36.1 peratus. Kajian juga mendapati tujuan remaja melayari internet ialah untuk menghilangkan kebosanan iaitu sebanyak 42.8 peratus. Manakala remaja mangsa buli siber didapati sering menerima kata-kata kotor dan lucah di laman sosial. Kajian ini memberi implikasi bahawa buli siber adalah satu masalah yang perlu diberi perhatian serius kerana kesannya terhadap perkembangan remaja. Turut dibincangkan juga ialah kaedah pencegahan dan intervensi bagi menangani buli siber dalam kalangan remaja.

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Mulizar, Mulizar, et Awaluddin Awaluddin. « Potret Tilawah Al-Qur’an : Analisis Lahn Membaca Al-Qur’an (Studi Pada Mahasiswa IAIN Langsa, Aceh) ». Islamika : Jurnal Ilmu-Ilmu Keislaman 22, n^o 2 (31 décembre 2022) : 143–60. http://dx.doi.org/10.32939/islamika.v22i2.1527.

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This study aims to describe what and forms of errors (lahn) in reading the Qur'an. This paper is the result of a case study using a descriptive analysis method with a qualitative approach, where the main data sources are observation and interviews in the form of tests, and documentation. The results of this study explain that the error (Lahn) in reading the Qur'an to students is in the mention of the hijaiyah letters that are not in place, then the type of error (lahn) hijaiyah letters that students often make when reading the Qur'an is the letters (lha), ('ain), (ha), and (dza) and the more dominant error (lahn) is lahn khufi compared to lahn jali. Then the problems faced by students are the main categories in recitation problems, then fluency with the type of letters that are less fluent when pronouncing hijaiyah letters, namely the main letters are (lha), (dhad), (ghain), (dza), ( ha), then it is difficult to distinguish the length of the short reading and fluency in reading so that there are still stuttering in reading.

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Goudswaard, Nelleke. « Infix allomorphy in Ida'an-Begak ». ZAS Papers in Linguistics 34 (1 janvier 2004) : 89–102. http://dx.doi.org/10.21248/zaspil.34.2004.205.

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Ida'an-Begak is a Western Malayo-Polynesian language spoken by approximately 6,000 people on the east coast of Sabah, Malaysia, Borneo and belongs to the Sabahan subgroup of the North Borneo subgroup (Blust 1998). Ida'an-Begak has three dialects, Ida'an, spoken in the villages of Segama to the west of Lahad Datu, Ida'an Sungai spoken in the Kinabatangan and Sandakan districts, and Begak spoken in Ulu Tungku, to the east of Lahad Datu (Banker 1984).1 Moody (1993) deals with Ida'an; this paper concentrates on the Begak dialect. In this paper I will present new data gathered in the field and provide an analysis of the allomorphy. The study is based on spontaneous data as well as examples elicited from my language informants.

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YAĞCI, Hızır. « EVALUATION OF LAHN ISSUE ACCORDING TO HADITHISTS ». Abant İzzet Baysal Üniversitesi İlahiyat Fakültesi Dergisi 10, n^o 1 (31 mai 2022) : 193–211. http://dx.doi.org/10.33931/dergiabant.1077318.

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The concept of lahn which was used in the early periods as taking the word in a different direction started to be used for expressions contrary to i‘rab However, in the examples given in the hadith sources, it is seen that the concept of lahn is used for expressions contrary to i‘rab, it is also used to cover grammatical errors in a general sense. The lahn which became widespread with the Arabs starting tol ive together with people from different ethnic origins, usually stems from not knowing Arabic and tasheef. Although muhaddithun accepted the absence of lahn in the narratör as an issue that strengthens the narrator’s dhabt, they ruled that the presence of lahn does not harm the narrator’s justice. For this reason, narrators who are known to make grammatical errors are also accepted as thiqa (reliable). It does not seem appropriate to claim that the narration assumed to be lahn is weak or fabricated fort his reason alone, since different uses arising from dialect differecens are not considered lahn and grammatical defects allegedely occuring as i‘rab errors can be interpreted differently. Because, it has been seen that there are other reasons why the narrations with grammatical errors are considered weak. The use of hypothetical examples by those who argue that the words cannot be trusted in the event that there is a situation in the hadith that violates the meaning also supports our opinion.

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EKER, Fevziye. « Ekinözü Lahdi Üzerine İlk Değerlendirme ». Cedrus, n^o 7 (30 juin 2019) : 575–87. http://dx.doi.org/10.13113/cedrus.201926.

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CANKURT, Fatih. « Lahn in Prayer Kiraat in Short Surahs ». Turkish Academic Research Review - Türk Akademik Araştırmalar Dergisi [TARR] 8, n^o 4 (6 décembre 2023) : 1577–600. http://dx.doi.org/10.30622/tarr.1372809.

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Nüzulünden itibaren Kur’ân okuyuşunda yapılabilecek her türlü hatayı (lahn) engellemek üzere büyük gayret sarf edilmiştir. Bu maksatla ehil üstatlarca okuyuş hatalarının üzerine durulmuş, ilgili eserlerde de Kur’ân kırâatinde sakınılması gereken noktalara işaret edilmiştir. Lahn konusu kaynaklarda lahn-ı celî ve lahn-ı hafî olmak üzere iki alt başlık altında incelenmiştir. Lahn-ı hafî, kıraat alanında belirli yeterliliğe sahip olanların fark edebileceği türden hataları ifade ederken, temel seviyede Kur’ân okuma bilgisine sahip kimselerin görebileceği yanlışlar lahn-ı celî kapsamında ele alınmıştır. Kelimenin aslında tağyire, manada değişime sebep olabildiği için bilhassa lahn-ı celi türünden hatalardan sakınılması önemlidir. Bu başlık altında yer alan harf/hareke değişimi, harflerin incelik/kalınlığına riâyet etmeme gibi hatalar, hatim vb. faaliyetlerde yapıldığı takdirde dahi çok mühim iken, aynı yanlışların namaz kırâati esnasında da ortaya çıkması, ifa edilen ibadetin makbuliyetine engel teşkil edebilmektedir. Bu çalışmada, namaz esnasında yapılan ve yapılabilecek kırâat hatalarının tespiti ve tashihi amaçlanmaktadır. Bu kapsamda, gerek derslerine girilen İlahiyat Fakültesi öğrencilerinin okuyuşunda tespit edilen gerekse farklı şehirlerdeki muhtelif camilerde şahit olunan kırâat hataları saptanıp ne şekilde düzeltilmesi gerektiği ifade edilmeye çalışılmıştır. Bu vesileyle mevcut yanlış okumaların detaylı biçimde tespit ve tashih edilmesi suretiyle yapılan/yapılması muhtemel hataları engellemeye vesile olabilme maksadı güdülmüştür. Kur’ân-ı Kerîm’de yer alan bütün sûrelerdeki muhtemel hataların tespiti bu çalışmanın maksadını aşacağı için bazı kısa sûreler ele alınmıştır. Bu bağlamda, namaz kırâatiyle ilgilisi bulunan Tekbir, İstiâze-Besmele lafızları, Fatiha sûresi ve namazlarda okunması mutat Kur’ân-ı Kerîm’in son on sûresinde (Fîl-Nâs Sûreleri) yapılan yanlışlar tespit edilmiş, bunların ne şekilde düzeltilmesi gerektiği hususu açıklanmaya gayret edilmiştir.

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Kaźmierska, Joanna, Michał R. Kaźmierski, Tomasz Bajon, Tomasz Winiecki, Anna Bandurska-Luque, Adam Ryczkowski, Tomasz Piotrowski, Bartosz Bąk et Małgorzata Żmijewska-Tomczak. « Prediction of Incomplete Response of Primary Tumour Based on Clinical and Radiomics Features in Inoperable Head and Neck Cancers after Definitive Treatment ». Journal of Personalized Medicine 12, n^o 7 (30 juin 2022) : 1092. http://dx.doi.org/10.3390/jpm12071092.

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Radical treatment of patients diagnosed with inoperable and locally advanced head and neck cancers (LAHNC) is still a challenge for clinicians. Prediction of incomplete response (IR) of primary tumour would be of value to the treatment optimization for patients with LAHNC. Aim of this study was to develop and evaluate models based on clinical and radiomics features for prediction of IR in patients diagnosed with LAHNC and treated with definitive chemoradiation or radiotherapy. Clinical and imaging data of 290 patients were included into this retrospective study. Clinical model was built based on tumour and patient related features. Radiomics features were extracted based on imaging data, consisting of contrast- and non-contrast-enhanced pre-treatment CT images, obtained in process of diagnosis and radiotherapy planning. Performance of clinical and combined models were evaluated with area under the ROC curve (AUROC). Classification performance was evaluated using 5-fold cross validation. Model based on selected clinical features including ECOG performance, tumour stage T3/4, primary site: oral cavity and tumour volume were significantly predictive for IR, with AUROC of 0.78. Combining clinical and radiomics features did not improve model’s performance, achieving AUROC 0.77 and 0.68 for non-contrast enhanced and contrast-enhanced images respectively. The model based on clinical features showed good performance in IR prediction. Combined model performance suggests that real-world imaging data might not yet be ready for use in predictive models.

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Lahne, Alexander. « Die formellen Anforderungen an einen Überprüfungsantrag nach § 44 SGB X aus dem Blickwinkel des SGB II ». TUP - Theorie und Praxis der Sozialen Arbeit, n^o 4 (2 décembre 2021) : 306–10. http://dx.doi.org/10.3262/tup2104306.

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Bezieher*innen von Leistungen nach dem SGB II haben prinzipiell Anspruch auf Überprüfungen ihrer Bescheide. Allerdings sind die Voraussetzungen solcher Prüfungen nicht vollständig geklärt. Verständlich und praxisnah erläutert Alexander Lahne die gesetzlichen Grundlagen und Anwendungsfälle.

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Hitt, R., J. J. Grau, A. Lopez-Pousa, A. Berrocal, C. Garcia Giron, A. Irigoyen, J. Sastre, J. Martinez, H. Cortes-Funes et J. Cruz-Hernandez. « Final results of a randomized phase III trial comparing induction chemotherapy with cisplatin/5-FU or docetaxel/cisplatin/5-FU follow by chemoradiotherapy (CRT) versus CRT alone as first-line treatment of unresectable locally advanced head and neck cancer (LAHNC) ». Journal of Clinical Oncology 27, n^o 15_suppl (20 mai 2009) : 6009. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.6009.

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6009 Background: Induction chemotherapy (IC) with TPF isa standard regimen for patients (pts) with locally advanced head and neck squamous cell carcinoma (N Engl J Med. 2007;357:1705–1715). However, CRT alone is standard treatment for unresectable LAHNC. We designed a trial to compare two different regimens of IC followed by CRT versus CRT alone in pts with unresectable LAHNC. Methods: Pts with unresectable, measurable LAHNC, adequate organ function, and ECOG 0–1 were enrolled and stratified according to primary tumor site. (IC) regimens (3 cycles): PF (cisplatin 100 mg/m2 day [d] 1, then 5-FU 1,000 mg/m2 continuous infusion [CI], d1–5, q21d); TPF (docetaxel 75 mg/m2 d1, cisplatin 75 mg/m2 d1, 5-FU 750 mg/m2 CI, d1–5, q21d plus G-CSF and ciprofloxacin). All pts were to receive CRT, consisting of conventional radiotherapy up to 70 Gy plus cisplatin 100 mg/m2 d 1, 22, 43. The primary end point was time to treatment failure (TTF) for (IC) vs. no (IC); secondary endpoints included locoregional control (LRC) rate and safety; 438 pts were needed to demonstrate a 15% difference in treatment failure (death, progression, surgery, other treatments) with α = 0.05, β = 0.2. Results: From December 2002 to June 2007, 439 pts were enrolled: IC 311 pts (TPF 155, PF 156) and CRT 128 pts. The majority of pts were: ECOG 1 (70%); oropharynx and oral cavity (63%); T4 (75%); N2-N3 (61%). In evaluable pts (at least 1 cycle), the median TTF was 12.5 months with IC/CRT vs. 4.9 months with CRT alone (p < 0.001; HR 0.57; 95%CI 0.44–0.74); LRC rate was 60.9% IC/CRT vs. 44.5% CRT (p = 0.003; OR = 0.52; 95%CI 0.3–0.81). Grade 3–4 adverse events (IC/CRT vs. CRT) occurred in 83% vs. 69% of pts and included febrile neutropenia (10% vs 1%), and stomatitis (43.7% vs 37%). Conclusions: This is the first phase III trial to demonstrate that (IC) followed by CRT significantly increases TTF and LRC compared with CRT alone in pts with unresectable LAHNC. IC/CRT should now be considered standard treatment for these pts. No significant financial relationships to disclose.

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Ham, Janneke, Chantal Driessen, Mathijs P. Hendriks, W. Edward Fiets, Bas Kreike, Ann Hoeben, Marije Slingerland et al. « Cost-effectiveness of prophylactic antibiotics to prevent pneumonia in patients treated with chemoradiotherapy (CRT) for locally advanced head and neck carcinoma (LAHNC). » Journal of Clinical Oncology 35, n^o 15_suppl (20 mai 2017) : 6075. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6075.

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6075 Background: Recently, we reported about a prospective randomized study (PANTAP-study) investigating the effect of prophylactic antibiotics in LAHNC pts treated with CRT. We did not show a reduction in pneumonias, but did find a significant decrease in the number of hospitalizations. Detailed quality of life (QoL) results have been reported elsewhere. Now we present the results of the cost-effectiveness analysis. Methods: A multicenter study was performed in LAHNC pts treated with CRT, i.e.cisplatin weekly or 3-weekly combined with radiotherapy for 42 or 49 days. The standard treatment group (STG) received no prophylactic antibiotics; the intervention group (IG) received prophylactic antibiotics, i.e. amoxicillin/clavulanic acid, from day 29 until 14 days after completion of CRT. QoL questionnaires, including EQ-5D, QLQ-C30, EORTC Head&Neck35 and PSSHN, were taken before start of CRT, before start of antibiotics, at the end of CRT and at the end of follow up. Costs of hospitalization, prophylactic antibiotics, pain medication and anti-emetics were taken into account for the cost-effectiveness analysis. Results: A total of 94 pts were randomized; 48 pts to the STG and 47 pts to the IG. Between the STG and IG we found a difference per patient in costs of hospitalization of €2076 and €682 (p = 0.03), respectively, but not in the costs for pain medication per patient €78 and €46, respectively, (p = 0.382). The total costs of hospitalization in combination with prophylactic antibiotics, pain medication and anti-emetics were €2462 and €1037 (p = 0.046) in the STG and IG respectively, leading to a difference in total costs per patient of €1425 in favor of the IG. There were no significant differences in QoL between the groups. Conclusions: Prophylactic antibiotics during CRT for LAHNC did not reduce the rate of pneumonias, but reduced the number of hospitalizations in the IG, which led to a significant reduction in costs. Given the lack of adverse clinical effects, the same QoL, the cost savings and the impact of costs of hospitalization on health care globally, we recommend the use of prophylactic antibiotics in LAHNC pts receiving CRT. Clinical trial information: NCT01598402.

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Lahn, Bruce. « Bruce Lahn ». New Scientist 192, n^o 2578 (novembre 2006) : 65. http://dx.doi.org/10.1016/s0262-4079(06)61139-1.

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Lemson, Tatiana Maria Silva Coelho. « A problemática na caracterização da classe dos pronomes em língua portuguesa ». Entrepalavras 10, n^o 7esp (13 janvier 2020) : 49. http://dx.doi.org/10.22168/2237-6321-7esp1705.

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o presente artigo faz uma revisão das opiniões de Câmara Jr. (1969) e Lahud (1979) sobre os traços que marcam uma classe de vocábulos denominada pela tradição gramatical e por vários linguistas de pronome. Começamos, assim, com Câmara Jr. discutindo as noções de campo simbólico e campo mostrativo e o papel dos pronomes em sua proposta de classes de natureza morfossemântica. Trabalhamos também com Lahud que, ao iniciar o seu estudo sobre as teorias clássicas dos pronomes, esclarece-nos que sua proposta visa a simplesmente procurar certos pontos de referências conceituais para a organização e a análise dos dados que dispõe sobre a dêixis. Procuramos, portanto, entender o porquê destas teorias não conseguirem ser mais eficientes, uma vez que a classe de vocábulos caracterizadas por elas como sendo pronominal não se encaixa totalmente dentro desses pontos de vista, ou seja, as teorias conseguem somente englobar parte destes vocábulos. Observamos, entretanto, que o ponto em comum entre estas teorias é a utilização da dêixis como marca pronominal.

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Peddi, Prakash, Runhua Shi, Binu Nair, Fred Ampil, Glenn M. Mills et Syed H. Jafri. « Cisplatin, Cetuximab, and Radiation in Locally Advanced Head and Neck Squamous Cell Cancer : A Retrospective Review ». Clinical Medicine Insights : Oncology 9 (janvier 2015) : CMO.S18682. http://dx.doi.org/10.4137/cmo.s18682.

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Efficacy of cisplatin versus cetuximab with radiation in locally advanced head and neck cancer (LAHNC) was evaluated. A total of 96 patients with newly diagnosed LAHNC treated at our institution between 2006 and 2011 with concurrent radiation and cisplatin (group A, n = 45), cetuximab (group B, n = 24), or started with cisplatin but switched to cetuximab because of toxicity (group C, n = 27) were reviewed. Chi-square test, analysis of variance, and log-rank test were used for analysis. The three groups had similar baseline characteristics, except for median age, T stage, albumin levels, hemoglobin levels, performance status, and comorbidities. A complete response (CR) was seen in 77%, 17%, and 67% of patients ( P < 0.001), respectively. There was no significant difference in median overall survival (OS) between groups A and C. The median OS for groups A and C was not reached (>65 months), even though it was significantly longer than median OS for group B (11.6 months; P ≤ 0.001). The 2-year OS in groups A and C is significantly higher than that in group B (70% for groups A and C, 22% for group B). There is no significant difference in progression-free survival (PFS) between groups A and C. The median PFS for these groups was not reached (>62 months), and is significantly longer than that for group B (4.3 months; P ≤ 0.001). The 2-year PFS of group A (67%) and group C (76%) was significantly longer than that of group B (20%). Cisplatin with radiation appears to be more efficacious even in suboptimal dosing than cetuximab with radiation in LAHNC but the two groups were not well matched.

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Farwell, Wildon R., Elizabeth Lawler, Subha Chittamooru et Marc F. Botteman. « S165 – Locally Advanced Head and Neck Cancer Treatment Patterns ». Otolaryngology–Head and Neck Surgery 139, n^o 2_suppl (août 2008) : P131. http://dx.doi.org/10.1016/j.otohns.2008.05.339.

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Objectives We assessed the extent of chemoradiation therapy (CRT) or high-dose platinum-based chemotherapy plus radiation (P-CRT) initiation for patients with stage III/IV, locally advanced head and neck cancer (LAHNC) treated in the VA New England Healthcare System (VA-NEHS), and identified the factors associated with such initiation. Methods Newly diagnosed LAHNC patients treated in the VA-NEHS (from 1996 to 2006) were identified from electronic records. Patients’ tumor staging (TNM), demographics, performance score, comorbidities, alcohol and tobacco use or dependence, and diagnosis year were abstracted via chart review. The primary outcome was the initial treatment strategy, grouped as CRT ± surgery (including P-CRT), chemotherapy (CT) ± surgery, radiation therapy (RT) ± surgery, surgery alone, or no treatment. Multiple logistic regressions compared odds of failure to initiate CRT or P-CRT across the aforementioned patient characteristics. Results Of 496 patients identified, 34.5%, 34.7%, 6.7%, and 5.4% initiated CRT, RT, CT, and surgery alone, respectively, whereas 18.8% were untreated. Most patients initiating CRT (59.7%) or CT (51.5%) received platinum-based chemotherapy. Predictors of failure to initiate CRT included diagnosis year 2002 (OR=3.57, 95% CI: 2.32, 5.55), age >65 years old (OR=2.47, 95% CI: 1.55, 3.92), performance score <90 (OR=2.27, 95% CI: 1.43, 3.59), and past/present alcohol use (OR=1.95, 95% CI: 1.08, 3.52). Similar factors predicted failure to initiate P-CRT. Conclusions Although CRT/P-CRT initiation increased over time, older patients, patients with poorer performance status, and those using alcohol were less likely to initiate CRT. Research is needed to describe treatment outcomes in LAHNC patients not initiating CRT/P-CRT.

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Sintang, Suraya, Assis Kamu et Baba Musta. « Ujian dalam Menghadapi Bencana Gempa Bumi Berdasarkan Pengalaman Masyarakat Muslim di Lahad Datu, Sabah (An Affliction in Coping with Earthquake Disasters as Experienced by Muslim community in Lahad Datu, Sabah) ». UMRAN - International Journal of Islamic and Civilizational Studies 9, n^o 2 (28 juin 2022) : 85–100. http://dx.doi.org/10.11113/umran2022.9n2.539.

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Natural disasters are an unavoidable nature, and this phenomenon has been proven to occur either from a religious or scientific perspective. From the Islamic point of view, natural disasters considered as test of faithfulness. This study endevours to conceptualise the meaning of trial and its relation to the understanding of the Muslim community in Lahad Datu. The study discusses action taken by them in facing this natural disaster. This study employed quantitative method through distributing questionnaires around the district of Lahad Datu. The descriptive analysis was done to analyse the relationship between the demographic background of Muslim respondents with their level of understanding and knowledge of earthquake as a test of God. The results showed that majority of respondents, 80 percent, had experienced an earthquake. The average knowledge of the respondents about the history of the earthquake in Lahad Datu is at a minimum level and it can be said that the knowledge about the earthquake is based on the current or latest knowledge that they have experienced themselves. Nevertheless, respondents had a basic knowledge of earthquake as shown on the physical actions they took after an earthquake such as being aware of increasing the level of family safety and participating in disaster awareness programs. The results also show the respondents’ belief that the earthquake is a test of God can be true because their actions and practices after the earthquake are more towards positive practices that are not contrary to Islamic teachings. The study concludes that a holistic approach through the integration of science (geology) and religion (Islam) should be highlighted as a method for improving disaster risk reduction management in Malaysia, especially victims involving the Muslim community.

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Ternes, Thomas. « Limburg/Lahn : Dom, Stadt an der Lahn, Wasserchemische Gesellschaft ». Vom Wasser 121, n^o 4 (décembre 2023) : 105. http://dx.doi.org/10.1002/vomw.202300018.

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Trifiletti, Daniel M., Andrew Smith, Nandita Mitra, Surbhi Grover, John N. Lukens, Roger B. Cohen, Paul Read, William M. Mendenhall, Alexander Lin et Samuel Swisher-McClure. « Beyond Positive Margins and Extracapsular Extension : Evaluating the Utilization and Clinical Impact of Postoperative Chemoradiotherapy in Resected Locally Advanced Head and Neck Cancer ». Journal of Clinical Oncology 35, n^o 14 (10 mai 2017) : 1550–60. http://dx.doi.org/10.1200/jco.2016.68.2336.

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Purpose To examine recent utilization and survival outcomes associated with use of adjuvant chemoradiotherapy (CRT) for patients with resected locally advanced head and neck cancer (LAHNC) with negative surgical margins (SM negative) and no extracapsular extension (ECE). Materials and Methods We conducted a retrospective observational cohort study using the National Cancer Database evaluating patients diagnosed in 2004 to 2012 with AJCC stage III to IVB squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx treated with definitive surgery and adjuvant radiotherapy (RT) or CRT. We identified a subset of patients with SM negative and no ECE (n = 10,870). We determined factors associated with CRT use and examined overall survival of patients receiving CRT versus RT. We further evaluated survival outcomes by number of lymph nodes involved to assess whether this was associated with benefit from CRT. Results Among patients with resected LAHNC with SM negative and no ECE, 47% received adjuvant CRT. The use of CRT varied substantially according to several factors, including patient age, contralateral/bulky neck disease, increasing number of positive lymph nodes, and lower neck disease. CRT was associated with a statistically significant improvement in overall survival compared with RT alone (hazard ratio, 0.90; 95% CI, 0.86 to 0.94; P < .001). Survival benefits of CRT versus RT alone increased in patients with multiple positive lymph nodes. Conclusion The use of adjuvant CRT in patients with resected LAHNC with SM negative and no ECE is common. Substantial practice variation as well as the survival differences observed in this study support the conduct of additional research to guide personalized treatment approaches in this setting. The number of positive lymph nodes seems to be an appropriate selection factor for further investigation of CRT in such patients.

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Bhide, Shreerang, Jen Lee, Isaac Garcia-Murillas, Ros Cutts, Tara Hurley, Lorna Grove, Christopher Nutting, Kate Newbold, Nicholas C. Turner et Kevin Harrington. « Predicting response to radical (chemo)radiotherapy (R-CRT) with circulating HPV DNA and tumor DNA (ctDNA) analysis in locally-advanced head and neck squamous cell carcinoma (LAHNC). » Journal of Clinical Oncology 35, n^o 15_suppl (20 mai 2017) : 6043. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6043.

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6043 Background: Following R-CRT for human papilloma virus positive (HPV+) and negative (HPV-) LAHNC, patients frequently undergo unnecessary neck dissection (ND) and/or repeated biopsies for abnormal PET-CT findings even in the presence of a complete pathological response (pCR), which causes significant morbidity. We assessed the role of circulating tumor DNA analysis in identifying patients with true residual disease. Methods: We prospectively recruited development (DC, n=55) and test (TC, n=33) cohorts of LAHNC patients having R-CRT. For HPV+ tumors we developed a novel amplicon based next generation sequencing assay (HPV-detect) to detect circulating HPV DNA and for HPV- tumors we used personalised droplet digital PCR assays of somatic mutations. Circulating tumor DNA levels at 12 weeks post-R-CRT were correlated to residual disease assessed by PET-CT and surgery. Results: In the DC (27 HPV+), baseline HPV-detect demonstrated 100% sensitivity and 93% specificity, confirmed in the TC (20 HPV+). 37 HPV+ patients (DC&TC) had complete samples-set. 36 had a negative HPV-detect at end of treatment, including 6 patients who underwent ND (3) and repeat primary site biopsies (3) for positive PET-CT but had pCR on surgical/biopsy specimen. 1 patient had positive HPV-detect and positive biopsy, indicating 100% agreement for HPV-detect and residual cancer. In a 10 HPV- patients with complete sample-set, there was 90% agreement between ctDNA and residual disease in HPV- tumors (3 ctDNA positive and tumor present, 1 ctDNA negative but tumor present, and 6 negative ctDNA negative tumor) with 80% sensitivity for residual disease and 100% specificity. Combined agreement between ctDNA testing (HPV+ and -) & residual disease was 98% (Table). Conclusions: Circulating HPV DNA quantified using HPV-detect and ctDNA identifies patients with residual disease post-R-CRT in LAHNC. Further studies are required to validate these findings. [Table: see text]

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Taufiqurrochman, Taufiqurrochman. « FENOMENA LAHN DALAM RITUAL IBADAH ». El-HARAKAH (TERAKREDITASI) 9, n^o 2 (13 août 2008) : 165. http://dx.doi.org/10.18860/el.v9i2.4653.

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One of the language characteristics is that it is composed of a certain sound system that is distinctive to each other. Alquran that is revealed in Arabic should be articulated appropriately and accurately in order to avoid mistakes, explicitly or implicitly. Lahn is called as solecism in linguistics and catachresis in literature. According to tajwid science (Alquran Phonology), Lahn is defined as. mis pronunciation in reading Alquran. That is why the readers should be able to learn more about tajwid. It is important to avoid making lahn that will change the meaning of the Holly Alquran. This article is aimed at describing lahn phenomenon that appears in religious activities such as adzan, iqamat, tahlil, talbiyah, and praying. Salah satu karakteristik bahasa ialah ia terdiri dari sistem bunyi tertentu yang dapat membedakannya dengan lainnya. Alquran yang tertulis dalam Bahasa Arab harus diartikulasikan dengan tepat dan akurat agar terhindar dari kesalahan baik itu yang tampak maupun yang tersembunyi. Lahn disebut sebagai kesalahan tata bahasa dalam ilmu Linguistik dan catachresis dalam ilmu Sastra. Menurut ilmu Tajwid (Fonologi Alquran), Lahn didefinisikan sebagai kesalahan pengucapan dalam membaca Alquran. Maka dari itu, pembaca harus mempelajari Tajwid lebih jauh lagi. Artikel ini bertujuan untuk mendeskripsikan fenomena Lahn yang tampak dalam aktivitas keagamaan seperti azan, iqamah, tahlil, talbiyah, dan berdoa.

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Siti Fharhana., Yusof, Wan Hassan Wan Muhamad Saridan, Ramli Ahmad Termizi, Sahini Mohd Hilmi, Mohd Sanusi Mohammad Syazwan, Basri Nor Afifah et Abu Hanifah Nor Zati Hani. « Environmental radiology assessment in Lahad Datu, Sabah ». EPJ Web of Conferences 156 (2017) : 00008. http://dx.doi.org/10.1051/epjconf/201715600008.

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Schöll, Franz. « Makrozoobenthos der Lahn unter besonderer Berücksichtigung des schiffbaren Abschnitts von Gießen bis Lahnstein ». Decheniana : Verhandlungen des Naturhistorischen Vereins der Rheinlande und Westfalens 170 (6 septembre 2023) : 108–26. http://dx.doi.org/10.21248/decheniana.v170.4952.

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Das Makrozoobenthos der Lahn von der Quelle bis zur Mündung wird beschrieben. Datengrundlage sind Untersuchungen der Bundesanstalt für Gewässerkunde (BfG) am schiffbaren Abschnitt aus dem Jahre 2016 sowie Makrozoobenthos-Erhebungen des Landesamtes für Natur, Umwelt und Verbraucherschutz NRW, (LANUV NRW), des Hessischen Landesamtes für Naturschutz, Umwelt und Geologie (HLNUG) und des Landesamtes für Umwelt Rheinland-Pfalz (LFU RLP) aus den Jahren 2010 - 2014. Insgesamt wurden mehr als 200 Arten nachgewiesen. Die vorgefundene Lebensgemeinschaft entspricht der typologischen und längszonalen Gliederung der Lahn, die allerdings durch anthropogen Einflüsse überprägt wird. Das Arteninventar der schiffbaren Lahn liegt deutlich über dem des Mittelrheins und der unteren Mosel. Unterschiede bezüglich der Verbreitung von Neozoen und einheimischen Arten erklären sich mit dem unterschiedlichen Grad des Ausbaus für die Schifffahrt. Die Analyse der ökologischen Valenzen zeigt, dass das Potential für eine Wiederherstellung einer flusstypischen Lebensgemeinschaft im schiffbaren Abschnitt vorhanden ist.

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Seth, Manvi. « International Seminar on Museums and the Changing Cultural Landscape, Ladakh ». Museum Worlds 1, n^o 1 (1 juillet 2013) : 204–5. http://dx.doi.org/10.3167/armw.2013.010113.

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The international seminar on Museums and the Changing Cultural Landscape, coordinated by Dr. Manvi Seth, was organized by the department of museology in the National Museum Institute of History of Art, Conservation and Museology in collaboration with the Ladakh Autonomous Hill Development Council (LAHDC) from 2–4 September 2012 at the Central Institute of Buddhist Studies (CIBS), Leh, Ladakh, India.

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Ishiki, Hiroto, Yusuke Onozawa, Takashi Kojima, Shuichi Hironaka, Akira Fukutomi, Hirofumi Yasui, Kentaro Yamazaki et al. « Nutrition Support for Head and Neck Squamous Cell Carcinoma Patients Treated with Chemoradiotherapy : How Often and How Long ? » ISRN Oncology 2012 (13 février 2012) : 1–5. http://dx.doi.org/10.5402/2012/274739.

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Background. Oral intake of many patients with locally advanced head and neck cancer (LAHNC) decrease during chemoradiotherapy (CRT). Although prophylactic percutaneous endoscopic gastrostomy (PEG) is recommended, not a few patients complete CRT without using PEG tube. Patients and Methods. The subjects were patients with LAHNC who received CRT. We retrospectively investigated the incidence and duration of nutritional support during and after CRT, and predicting factors of nutritional support. For patients who required nutritional support, we also checked the day of initiation and the duration of nutritional support. Results. Of 53 patients, 29 patients (55%) required nutritional support during and/or after CRT. While no clear relation between requirement of nutritional support and variables including age, T stage, N stage, clinical stage and chemotherapy regimen, there could be some relationships between tumor primary sites and the requirement and duration of nutritional support. 17 (77%) of 22 patients with oropharynx cancer(OP) required nutritional support and prolonged for 4.4 months, and 11 (46%) of 24 patients with hypopharynx cancer(HP) required nutritional support and prolonged for 21.9 months. Conclusion. Nutritional support is indicated many HNC patients treated with CRT and primary sites may have some relation to its indication and duration.

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Hu, Ming-Hung, Ling-Wei Wang, Hsueh-Ju Lu, Pen-Yuan Chu, Shyh-Kuan Tai, Tsung-Lun Lee, Ming-Huang Chen, Muh-Hwa Yang et Peter Mu-Hsin Chang. « Cisplatin-Based Chemotherapy versus Cetuximab in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Cancer Treatment ». BioMed Research International 2014 (2014) : 1–7. http://dx.doi.org/10.1155/2014/904341.

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Background and Purpose. This study aimed to analyze survival, clinical responses, compliance, and adverse effects in locally advanced head and neck cancer (LAHNC) patients treated with split-dose cisplatin-based concurrent chemoradiation therapy (SD-CCRT) or cetuximab with concurrent radiation therapy (BioRT).Materials and Methods. We retrospectively evaluated 170 LAHNC patients diagnosed between January 1, 2009, and July 31, 2012: 116 received CCRT and 54 received BioRT.Results. Complete response rates were similar in the SD-CCRT and BioRT groups (63.8% versus 59.3%;P=0.807), and locoregional relapse rates were 18.1% and 13.0%, respectively (P=0.400). The 3-year relapse-free survival rate was 65.8% in the SD-CCRT group and 65.5% in the BioRT group, respectively (P=0.647). The 3-year overall survival rate was 78.5% in the SD-CCRT group and 70.9% in the BioRT group, respectively (P=0.879). Hematologic side effects were significantly more frequent in the SD-CCRT than in the BioRT group. Mucositis frequency was similar.Conclusions. Primary SD-CCRT and BioRT both showed good clinical response and survival. Hematologic toxicities were more frequent, but tolerable, in the SD-CCRT group. Both groups showed good compliance.

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Hitt, R., J. Grau, A. Lopez-Pousa, A. Berrocal, C. García-Giron, J. Belon, J. Sastre, J. Martinez-Trufero, H. Cortés-Funes et J. Cruz-Hernandez. « Randomized phase II/III clinical trial of induction chemotherapy (ICT) with either cisplatin/5-fluorouracil (PF) or docetaxel/cisplatin/5-fluorouracil (TPF) followed by chemoradiotherapy (CRT) vs. crt alone for patients (pts) with unresectable locally advanced head and neck cancer (LAHNC) ». Journal of Clinical Oncology 24, n^o 18_suppl (20 juin 2006) : 5515. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.5515.

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5515 Background: we have previously reported that ICT plus CRT is more active than CRT alone in pts with unresectable LAHNC (Hitt et al: ASCO 2005, abstract 5578). Here we present new data of efficacy and time to progression (TTP) in this trial. Methods: Patients: eligible pts included those with unresectable LAHNC, measurable disease, adequate organ function and ECOG 0–1. Pts were stratified according to primary tumor site. Treatment: Induction chemotherapy regimens (3 cycles): PF : P 100 mg/m2 day (d) 1, then F 1000 mg/m2 c.i. d1–5 q 21d; TPF: T 75 mg/m2 d1, P 75 mg/m2 d1, F 750 mg/m2 c.i. d 1–5 q 21 d plus G-CSF and ciprofloxacin. Chemoradiotherapy: conventional RT up to 70 Gy plus P 100 mg/m2 d 1–22–43 Results: Patients: a total of 310 pts have been accrued. Pts/tumor characteristics (ECOG, age, primary site, T/N stage) were well balanced among the three arms. T/N stage: T3–4 (88%); N2–3 (63%); pharynx-oropharynx site (62%). Treatment: Median number of cycles of ICT: 3; median dose of RT: 70 Gy, median number of cycles of P during RT in three arms: 3. Efficacy: Complete Response: 70% (ICT + CRT) vs. 49% (CRT alone) (p = 0.01). The response rate was similar between TPF and PF. Time to progression (TTP) in months: 16 (TPF + CRT); 12 (PF + CRT) vs 8 (CRT alone) (log-Rank= 0.02). G 3/4 toxicity (NCI criteria): Febrile neutropenia: 21% (TPF); mucositis: 10% (PF). Mucositis was observed in 55% (TPF + CRT), 60% (PF + CRT) and 36% (CRT alone) of the pts, respectively Conclusions: The results of the present randomised clinical trial demonstrate that the combination of ICT + CRT significantly increases the complete response rate and prolongs TTP when compared to CRT alone in patients with unresectable LAHNC. No significant financial relationships to disclose.

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Taberna, Miren, Cinta Hierro, Marc Diez, Jaime Canellas, Mivael Olivera, Silvia Vazquez, Valentín Navarro-Perez et al. « Influence of treatment received in long surviving patients of head and neck cancer. » Journal of Clinical Oncology 31, n^o 15_suppl (20 mai 2013) : e17010-e17010. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e17010.

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e17010 Background: Modification of radiotherapy (RT) schedules or the addition of CT/biologics in patients (pts) with locally advanced head-and-neck carcinomas (LAHNC) have resulted in improving survival, although this means increased morbidity. Our aim was to analyze late toxic effects that present our long survivors pts and how much these may affect their lives. Methods: We have prospectively assessed late toxicity based on the RTOG scoring system in 152 consecutive LAHNC long-term survivors treated from 1994 to 2009 in an outpatient clinic. All of them had received concomitant treatment or fractionated RT with or without induction. Multivariate logistic regressions (logit link) for toxicity were performed to detect toxicity factors, p-values and confidence intervals at 95 % level (CI). Pts also answered about the degree of life-affecting by these sequelae. Results: Median age 63 (29-78), 136 men. All received radical treatment with: RT alone (21%), concomitant RT with cisplatin (P) (51%) or cetuximab (C) (28%). Previous induction platinum-based CT was administered in 56% pts. Median dose RT: 70 Gy (60-80), with different fractionations. All pts had at least one grade 1-2 late effect and 21% experienced grade 3-4 toxicity. The most common toxicities are shown in the Table. Concomitant C was found to be an independent risk factor of decreasing late toxicity compared with P in the adjusted analysis by RT fraction: Grade 1-2 toxicity OR 0.292 (CI: 0.125-0.680, p: ,04) and grade 3-4 toxicity OR 0.299 (CI: 0.0909-0.999, p: ,05). 41% of pts felt their quality of life as no disabling and 17% as very disabling. Conclusions: Having chronic toxicity in long survivors with a LAHNC is very common, but the vast majority of them learn to adapt to it. The type of treatment performed clearly affect this late toxicity: pts treated with concomitant P have significant more late toxicity compared with the association with C. [Table: see text]

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Ilyas, Muhammad Azizzullah. « Diskursus Pemikiran Al-Jahiz Mengenai Gangguan Berbahasa ». Arabiyatuna : Jurnal Bahasa Arab 2, n^o 2 (26 décembre 2018) : 201. http://dx.doi.org/10.29240/jba.v2i2.572.

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The study of language pathology has been going on longer and developing with the development of language studies, the problems encountered in learning speaking skills are often related to speech skills which sometimes enter the language pathology area which requires educator knowledge especially the interference of Arabic learners. This study aims to analyze speech problems and language in the classical study represented by Al-Jahiz seen through the perspective of modern linguistics. This study uses a qualitative approach with library data sources, descriptive analysis is done by reading the content and analyzed. The results showed that Al-Jahiz's views were divided into speech disorders and language disorders; lusghah, luknah, lahn and ayy. Jahiz saw lahn as the worst speech disorder, and he assumed that in lahn is not only caused by articulation factors and motor aphasia but can also be driven by personal factors to replace sounds that are difficult to pronounce with light sounds.

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Mohd Tamring, Budi Anto, Mohd Sohaimi Esa, Romzi Ationg, Mohd Azri Ibrahim, Irma Wani Othman, Siti Aidah Lukin @ Lokin et Sharifah Darmia Sharif Adam. « EDUCATION ISSUES AMONG THE PALA'U COMMUNITY IN LAHAD DATU, SABAH ». International Journal of Law, Government and Communication 6, n^o 23 (30 avril 2021) : 01–22. http://dx.doi.org/10.35631/ijlgc.623001.

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Education is no longer a local or national issue but a universal issue affecting the world today. It has become fundamental to the development of society as well as a key element of any government agenda globally. It also began to play it significant in the community of immigrants or the stateless. The documentation and their citizenship status which are highly debated, thus, have not only sparked another issue such as politics and international relations but also social issues such as humanitarian associated with education. The Pala’u of Lahad Datu has been among the community encountering citizenship and other issues in Malaysia. This study examines the education issues affecting the Pala’u in Lahad Datu, involving 136 participants who provided their responses through a set of survey questionnaires. The study shows that their traditional way of life of being so much atteched with the sea made the viewer's education less important. Apart from that, factors such as bullying in the school, access to school, their nomadic nature of life, and low awareness among their parents also have been the reason why they did not attend school. Moreover, the documentation or the citizenship problem also made the Pala’u ineligible to access school according to Malaysia law.

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Yeh, Kun-Yun, Hang Huong Ling, Shu-Hang Ng, Cheng-Hsu Wang, Pei-Hung Chang, Wen-Chi Chou, Fang-Ping Chen et Yu-Ching Lin. « Role of the Appendicular Skeletal Muscle Index for Predicting the Recurrence-Free Survival of Head and Neck Cancer ». Diagnostics 11, n^o 2 (14 février 2021) : 309. http://dx.doi.org/10.3390/diagnostics11020309.

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Background: This study investigates whether the appendicular skeletal muscle index (ASMI) was an independent prognostic predictor for patients with locally advanced head and neck cancer (LAHNC) receiving concurrent chemoradiotherapy (CCRT) and whether there were any differences in lean mass loss in different body regions during CCRT. Methods: In this prospective study, we analyzed the clinicopathological variables and the total body composition data before and after treatment. The factors associated with the 2-year recurrence-free survival rate (RFSR) were analyzed via logistic regression analysis. Results: A total of 98 patients were eligible for analysis. The body weight, body mass index, and all parameters of body composition significantly decreased after CCRT. The pretreatment ASMI was the only independent prognostic factor for predicting the 2-year RFSR (hazard ratio, 0.235; 95% confidence interval, 0.062–0.885; p = 0.030). There was at least 5% reduction in total lean and fat mass (p < 0.001); however, the highest lean mass loss was observed in the arms (9.5%), followed by the legs (7.2%), hips (7.1%), waist (4.7%), and trunk (3.6%). Conclusions: The pretreatment ASMI was the only independent prognostic predictor for the 2-year RFSR of LAHNC patients undergoing CCRT. Asynchronous loss of lean mass may be observed in different body parts after CCRT.

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