Bibliographies thématiques / KL6

Littérature scientifique sur le sujet « KL6 »

Auteur : Grafiati

Publié le 10 mars 2023

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Articles de revues sur le sujet "KL6"

Thuy Duong, Nguyen Thi. « SELECTION OF INDIGENOUS STRAINS (Paecilomyces lilacinus) PARASITIZE Meloidogyne spp. ISOLATED FROM BA RIA – VUNG TAU PROVINCE ». Vietnam Journal of Science and Technology 55, n^o 1A (24 avril 2018) : 27. http://dx.doi.org/10.15625/2525-2518/55/1a/12379.

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Twenty two Paecilomyces lilacinus strains were isolated from forest soils and black pepper rhizospheres in Ba Ria –Vung Tau Province. The ability to degrade chitin of PB 3.3, PB 2.9, QT2, and QT5 strains was high. The ability to degrade casein of PB 1.3, PB 2.10, KL5, and KL6 strains was efficient. And then, these strains were parasitized females and egg masses of Meloidogyne spp. in vitro. In female parasitism test, the rates of parasitizing female nematodes reached more than 50 % after treating for 2 days. Four strains of PB 2.10, PB 1.3, KL6 and QT5 belonged to the first group achieved the highest parasitic (> 90 %) effects on female after 3 days of incubation. In egg masses parasitism test, three strains of PB 1.3, PB 2.10 and QT5 exhibited 83.33 %, 75 % and 75 % parasitism on egg masses after 11 days of incubation. The rates of parasitizing female were higher than egg masses. Three selected strains from the experiments were PB 1.3, PB 2.10 and QT5.

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LEIGH, I. M., H. NAVSARIA, P. E. PURKIS, I. A. MCKAY, P. E. BOWDEN et P. N. RIDDLE. « Keratins (Kl6 and Kl7) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro ». British Journal of Dermatology 133, n^o 4 (octobre 1995) : 501–11. http://dx.doi.org/10.1111/j.1365-2133.1995.tb02696.x.

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Zhao, Lina, Xinxin Xia, Ting Yuan, Junying Zhu, Zhen Shen et Min Li. « Molecular Epidemiology of Antimicrobial Resistance, Virulence and Capsular Serotypes of Carbapenemase-Carrying Klebsiella pneumoniae in China ». Antibiotics 11, n^o 8 (13 août 2022) : 1100. http://dx.doi.org/10.3390/antibiotics11081100.

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This study analyzed genomic data of 4643 strains of carbapenemase-carrying Klebsiella pneumoniae (KPN) in China by using the Kleborate software package. The data showed rich diversity in carbapenemase-carrying KPN genomes, which contain not only 152 sequence types but also 90 capsular serotypes. In 2013, the transfer of carbapenemase to hypervirulent Klebsiella pneumoniae (HvKP) of KL1 and KL2 occurred, and since 2014, the propagation of carbapenemase into mammals, poultry, and insects has been detected. The ST11 capsular serotype had a reversal of the prevalence of KL47 and KL64 in 2016, with KL64 replacing KL47 as the dominant serotype. Colibactin is a very suitable indicator to differentiate KL1-type HvKP and classic Klebsiella pneumoniae. The most prevalent yersiniabactin of KL1 is ybt1 ICEKp10, and that of ST11 carbapenem-resistant KPN(ST11-CRKP) is ybt9 ICEKp3. The virulence genes of KL1 carbapenem-resistant hypervirulent KPN (KL1-CRHvKP), as well as ST65- and ST86-type KL2-CRHvKP, were not lost after carbapenemase was obtained.

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Edd, Shannon N., Patrick Omoumi, Brigitte M. Jolles et Julien Favre. « Longitudinal Femoral Cartilage T2 Relaxation Time and Thickness Changes with Fast Sequential Radiographic Progression of Medial Knee Osteoarthritis—Data from the Osteoarthritis Initiative (OAI) ». Journal of Clinical Medicine 10, n^o 6 (21 mars 2021) : 1294. http://dx.doi.org/10.3390/jcm10061294.

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This study tested for longitudinal changes in femoral cartilage T2 relaxation time and thickness in fast-progressing medial femorotibial osteoarthritis (OA). From the Osteoarthritis Initiative (OAI) database, nineteen knees fulfilled the inclusion criteria, which included medial femorotibial OA and sequential progression from Kellgren–Lawrence grade (KL) 1 to KL2 to KL3 within five years. Median T2 value and mean thickness were calculated for six condylar volumes of interest (VOIs; medial/lateral anterior, central, posterior) and six sub-VOIs (medial/lateral anterior external, central, internal). T2 value and thickness changes between severity timepoints were tested using repeated statistics. T2 values increased between KL1 and KL2 and between KL1 and KL3 in the medial compartment (p ≤ 0.02), whereas both increases and decreases were observed between the same timepoints in the lateral compartment (p ≤ 0.02). Cartilage thickness decreased in VOI/subVOIs of the medial compartment from KL1 to KL2 and KL3 (p ≤ 0.014). Cartilage T2 value and thickness changes varied spatially over the femoral condyles. While all T2 changes occurred in the early radiographic stages of OA, thickness changes occurred primarily in the later stages. These data therefore support the use of T2 relaxation time analyses in methods of detecting disease-related change during early OA, a valuable period for therapeutic interventions.

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Aoshima, Yoichiro, Yasunori Enomoto, Shigeki Muto, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa et al. « Gremlin-1 for the Differential Diagnosis of Idiopathic Pulmonary Fibrosis Versus Other Interstitial Lung Diseases : A Clinical and Pathophysiological Analysis ». Lung 199, n^o 3 (26 mars 2021) : 289–98. http://dx.doi.org/10.1007/s00408-021-00440-y.

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Abstract Purpose The differential diagnosis of interstitial lung diseases (ILDs), particularly idiopathic pulmonary fibrosis (IPF) versus other non-IPF ILDs, is important for selecting the appropriate treatment. This retrospective study aimed to explore the utility of gremlin-1 for the differential diagnosis. Methods Serum gremlin-1 concentrations were measured using an ELISA in 50 patients with IPF, 42 patients with non-IPF ILD, and 30 healthy controls. The baseline clinical data, including pulmonary functions, prognosis, and three serum biomarkers (Krebs von den Lungen-6 [KL6], surfactant protein-D [SP-D], and lactate dehydrogenase [LDH]), were obtained through a medical record review for analyzing their associations with serum gremlin-1 concentrations. To evaluate the origin of gremlin-1, we performed immunostaining on lung sections. Results Serum gremlin-1 concentrations were significantly higher in patients with IPF (mean concentration, 14.4 ng/mL), followed by those with non-IPF ILD (8.8 ng/mL) and healthy controls (1.6 ng/mL). The area under the curve for IPF versus non-IPF ILDs was 0.759 (95% confidence interval, 0.661–0.857), which was superior to that of KL6/SP-D/LDH. The sensitivity and specificity for gremlin-1 (cutoff, 10.4 ng/mL) was 72 and 69%, respectively. By contrast, serum gremlin-1 concentrations were not associated with the pulmonary functions nor the prognosis in all patients with ILDs. In immunostaining, the gremlin-1 was broadly upregulated in IPF lungs, particularly at myofibroblasts, bronchiolar/alveolar epithelium, and CD163-positive M2-like macrophages. Conclusions Gremlin-1 may be a useful biomarker to improve the diagnostic accuracy for IPF compared to non-IPF ILDs, suggesting a role of this molecule in the pathogenesis of IPF.

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Zhou, Ying, Chunyang Wu, Bingjie Wang, YanLei Xu, Huilin Zhao, Yinjuan Guo, Xiaocui Wu et al. « Characterization difference of typical KL1, KL2 and ST11-KL64 hypervirulent and carbapenem-resistant Klebsiella pneumoniae ». Drug Resistance Updates 67 (mars 2023) : 100918. http://dx.doi.org/10.1016/j.drup.2023.100918.

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Ballester, Milara et Cortijo. « Mucins as a New Frontier in Pulmonary Fibrosis ». Journal of Clinical Medicine 8, n^o 9 (11 septembre 2019) : 1447. http://dx.doi.org/10.3390/jcm8091447.

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Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary disease with a median survival of 3–5 years after diagnosis. Recent evidence identifies mucins as key effectors in cell growth and tissue remodeling processes compatible with the processes observed in IPF. Mucins are classified in two groups depending on whether they are secreted (secreted mucins) or tethered to cell membranes (transmembrane mucins). Secreted mucins (MUC2, MUC5AC, MUC5B, MUC6-8 and MUC19) are released to the extracellular medium and recent evidence has shown that a promoter polymorphism in the secreted mucin MUC5B is associated with IPF risk. Otherwise, transmembrane mucins (MUC1, MUC3, MUC4, MUC12-17 and MUC20) have a receptor-like structure, sensing the external environment and activating intracellular signal transduction pathways essential for mucosal maintenance and damage repair. In this context, the extracellular domain can be released to the external environment by metalloproteinase action, increased in IPF, thus activating fibrotic processes. For example, several studies have reported increased serum extracellular secreted KL6/MUC1 during IPF acute exacerbation. Moreover, MUC1 and MUC4 overexpression in the main IPF cells has been observed. In this review we summarize the current knowledge of mucins as promising druggable targets for IPF.

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Conticini, E., M. D’alessandro, L. Bergantini, D. Castillo, P. Falsetti, P. Cameli, E. Bargagli, L. Cantarini et B. Frediani. « POS0823 KL-6 IN ANCA-ASSOCIATED VASCULITIS PATIENTS WITH AND WITHOUT ILD : A MACHINE LEARNING APPROACH ». Annals of the Rheumatic Diseases 81, Suppl 1 (23 mai 2022) : 702.2–703. http://dx.doi.org/10.1136/annrheumdis-2022-eular.480.

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BackgroundANCA-associated vasculitis (AAV) are small vessel vasculitis which may variously affect upper and lower respiratory tract. Patients with microscopic polyangiitis (MPA) and, less commonly, granulomatosis with polyangiitis (GPA), especially those who are ANCA-MPO-positive, may suffer from interstitial lung disease (ILD), which is associated with high morbidity and mortality as it is often underdiagnosed and responds poorly to conventional treatmentsObjectivesIn this study, we aimed to assess whether Krebs von den Lungen-6 (KL-6), a marker of fibrotic ILD, may be useful for distinguishing AAV patients with ILD from those without ILD, and whether its changes over time are correlated with disease activity.MethodsWe enrolled all consecutive patients evaluated in the period December 2020 - November 2021. Inclusion criteria were a diagnosis of GPA or MPA, active disease, and eligibility for Rituximab treatment according to EULAR recommendations. All patients underwent concomitant rheumatological and pneumological evaluation, lung function tests, routine blood tests, autoimmunity evaluation and KL-6 assay. Current and previous treatments, Birmingham vasculitis score (BVAS) and vasculitis damage index were also recorded.ResultsA total of 13 patients (Table 1) were enrolled. One was excluded due to a concomitant diagnosis of lung cancer. Higher serum KL-6 were in AAV-ILD compared with those without ILD (972.8±398.5 vs 305.4±93.9, p=0.0040). Area under the Receiver Operating Characteristics curve showed 100% of the diagnostic performance of KL-6 for identifying the ILD involvement (accuracy 91.7%) and the best cutoff value of 368 U/mL (Sensitivity 100% and specificity 87.5%). The decision-tree model showed a 33% improvement in class purity using a cut-off value of 513 U/mL to distinguish AAV patients with and without ILD (Figure 1). Stratifying AAV patients as MPA and GPA with and without ILD considering T0 and T1 KL-6, the model obtained an improvement of 40% for classifying GPA non-ILD with a T0 serum KL-6 cut-off value of 513 U/mL and a T1 KL-6 cut-off of 301 U/mL. A direct correlation was found between serum T0 KL-6 and T0 BVAS (r=0.578, p=0.044).Table 1.Patients’ featuresSex/ageDiagnosisLength of disease * (months)Organs involvedType of lung involvementT0 KL6 levelsT0 BVAST0 VDIT1 KL6 levelsT1 BVAST1 VDIF/83MPA28Lung, kidney, PNSILD, alveolar hemorrhage6258732507M/48GPA1Lung, kidney, nose, eyeNodules35218027920F/55GPA252Lung, skinNodules40115360233F/38MPA1Skin-34760---F/74MPA180Kidney, PNS-36811541405M/77MPA8Lung, kidney, PNS, skinILD, alveolar hemorrhage982241---F/49GPA60Nose, eye-1226211602M/60MPA40Skin, PNS-20591---F/39GPA4Nose-31063---M/71GPA24Lung, eye, jointsNodules, ILD152893---F/64MPA24LungILD7564-10030-F/59GPA72LungNodules3384--0-Figure 1.ROC curve and decision tree modelConclusionOur multicentre study demonstrated KL-6 as a reliable, non-invasive and easy-to-perform marker of ILD in AAV patients and its helpfulness for disease activity assessment. Changes in serum concentrations of KL-6 over time could be useful for monitoring AAV patients. Further study of KL-6 as a marker of response to therapy during long-term follow-up would also be worthwhile.Disclosure of InterestsNone declared

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Milara, Javier, Beatriz Ballester, Paula Montero, Juan Escriva, Enrique Artigues, Manuel Alós, Alfonso Pastor-Clerigues, Esteban Morcillo et Julio Cortijo. « MUC1 intracellular bioactivation mediates lung fibrosis ». Thorax 75, n^o 2 (4 décembre 2019) : 132–42. http://dx.doi.org/10.1136/thoraxjnl-2018-212735.

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BackgroundSerum KL6/mucin 1 (MUC1) has been identified as a potential biomarker in idiopathic pulmonary fibrosis (IPF), but the role of MUC1 intracellular bioactivation in IPF is unknown.ObjectiveTo characterise MUC1 intracellular bioactivation in IPF.Methods and resultsThe expression and phosphorylation of Thr41 and Tyr46 on the intracellular MUC1-cytoplasmic tail (CT) was increased in patients with IPF (n=22) compared with healthy subjects (n=21) and localised to fibroblasts and hyperplastic alveolar type II cells. Transforming growth factor (TGF)-β1 phosphorylated SMAD3 and thereby increased the phosphorylation of MUC1-CT Thr41 and Tyr46 in lung fibroblasts and alveolar type II cells, activating β-catenin to form a phospho-Smad3/MUC1-CT and MUC1-CT/β-catenin nuclear complex. This nuclear complex promoted alveolar epithelial type II and fibroblast to myofibroblast transitions, as well as cell senescence and fibroblast proliferation. The inhibition of MUC1-CT nuclear translocation using the inhibitor, GO-201 or silencing MUC1 by siRNA, reduced myofibroblast transition, senescence and proliferation in vitro. Bleomycin-induced lung fibrosis was reduced in mice treated with GO-201 and in MUC1-knockout mice. The profibrotic lectin, galectin-3, directly activated MUC1-CT and served as a bridge between the TGF-β receptor and the MUC1-C domain, indicating TGF-β1-dependent and TGF-β1-independent intracellular bioactivation of MUC1.ConclusionsMUC1 intracellular bioactivation is enhanced in IPF and promotes fibrotic processes that could represent potential druggable targets for IPF.

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Bentov, Itay, Goutham Narla, Hagit Schayek, Kuhihara Akita, Stephen R. Plymate, Derek LeRoith, Scott L. Friedman et Haim Werner. « Insulin-Like Growth Factor-I Regulates Krüppel-Like Factor-6 Gene Expression in a p53-Dependent Manner ». Endocrinology 149, n^o 4 (3 janvier 2008) : 1890–97. http://dx.doi.org/10.1210/en.2007-0844.

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High-circulating IGF-I concentrations are associated with an increased risk for breast, prostate, and colorectal cancer. Krüppel-like factor-6 (KLF6) is a zinc finger tumor suppressor inactivated in prostate and other types of cancer. We have previously demonstrated that KLF6 is a potent transactivator of the IGF-I receptor promoter. The aim of the present study was to examine the potential regulation of KLF6 gene expression by IGF-I. The human colon cancer cell lines HCT116 +/+ and −/− (with normal and disrupted p53, respectively) were treated with IGF-I. Western blots, quantitative RT-PCR, and transfection assays were used to evaluate the effect of IGF-I on KLF-6 production. Signaling pathway inhibitors were used to identify the mechanisms responsible for regulation of KLF6 expression. Small interfering RNA against p53 and KLF6 was used to assess the role of p53 in regulation of KLF6 expression by IGF-I and to evaluate KLF6 involvement in cell cycle control. Results obtained showed that IGF-I stimulated KLF-6 transcription in cells with normal, but not disrupted, p53, suggesting that KLF6 is a downstream target for IGF-I action. Stimulation of KLF6 expression by IGF-I in a p53-dependent manner may constitute a novel mechanism of action of IGF-I, with implications in normal cell cycle progression and cancer biology.

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Thèses sur le sujet "KL6"

Beynon, Linda M. « Structural studies of Escherichia coli K26 and K46-50 using chemical and microbiological methods ». Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24480.

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The capsular polysaccharides of Escherichia coli are immunogenic and antigenic. When conjugated to a carrier protein these polysaccharides can be used as vaccines. A knowledge of the structure of bacterial capsular polysaccharides is essential for understanding antibody-antigen interaction and also for understanding the chemical basis of serological differentiation. For these reasons structural studies of some E. coli capsular polysaccharides are being undertaken in this laboratory. In this thesis a preliminary investigation into the structures of capsular polysaccharides from E. coli serotypes K/46, K/47, K/48, K49 and K50 is presented. The qualitative composition of each polysaccharide was determined by varying the hydrolytic conditions used to cleave the glycosidic bonds between the monosaccharide units. Table I shows the sugars present in each capsular polysaccharide. [Table Omitted] The ratio of the sugars in each polysaccharide was determined using methanolysis followed by reduction with sodium borohydride. The presence of amino sugars was confirmed by deamination of the hydrolyzed polysaccharide and detection of the product by g.l.c. G.l.c.-m.s., of the alditol acetates of the monosaccharides obtained by hydrolysis of the polysaccharides, was used to confirm the type of monsaccharide. present in each polysaccharide, ₁H-N.m.r. spectroscopy was utilized to confirm the presence of deoxy sugars, amino sugars and non-carbohydrate substituents. E. coli K47 and K50 capsular polysaccharides were both found to have pyruvate present as a substituent. A bacteriophage was isolated from sewage for each of E. coli K47, K48 and K49 serotypes. Phage 47 also attacked E. coli K48 and K49 bacteria. The structure of E. coli K26 capsular polysaccharide was investigated using the techniques of acid hydrolysis, carbodiimide reduction and methanolysis followed by reduction with sodium borohydride. The polysaccharide was degraded using a bacteriophage-borne glycanase. The position of cleavage found by methylation of the reduced oligosaccharide. Combination of the data obtained from the chemical analysis, n.m.r spectroscopy and the bacteriophage degradation gave the two following possible structures for the E. coli K26 capsular polysaccharide. [Formula Omitted]
Science, Faculty of
Chemistry, Department of
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Islamovic, Mirnes. « Cross-Laminated Timber– En fallstudie av Hyttkammaren samt en jämförelse med prefabricerat betongelement ur platsomkostnadsperspektiv ». Thesis, Högskolan i Halmstad, Sektionen för ekonomi och teknik (SET), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-23766.

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Thorselius, Klara. « K16 ». Thesis, Konstfack, Textil, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:konstfack:diva-5585.

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Barrett, George Alexander. « Kinesiographic lesion monitoring (KLM) / ». Thesis, Connect to this title online ; UW restricted, 2003. http://hdl.handle.net/1773/6026.

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Züllig-Morf, Sonja. « Qualitätskontrolle proteinhaltiger Fertigarzneimittel ; Gehalts-, Reinheits- und Stabilitätsuntersuchungen an KLP-602® bzw. Lydium-KLP® / ». Zürich : [s.n.], 2002. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14656.

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Volyanik, Elena Vitalyevna. « Studies on the role of C/EBPÎ² and GADD153 in the regulation of K6 and K16 gene expression in the context of keratinocyte activation ». Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408727.

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Nguyen, The Quyen. « Caractérisation structurale du recrutement de la protéine JIP1 par la chaîne légère (KLC) de la kinésine1 ». Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS250/document.

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RésuméLes kinésines sont des moteurs moléculaires impliqués dans le transport intracellulaire de nombreux cargos au sein de la cellule. Bien que la motilité des kinésines soit bien comprise, les mécanismes moléculaires à la base du recrutement des cargos le sont beaucoup moins.La kinésine1 joue divers rôles dans les cellules neuronales, où elle contribue à l’organisation spatiale et temporelle de nombreux composants cellulaires. Elle jouerait un rôle dans différentes pathologies neurologiques, comme la maladie d’Alzheimer. Comprendre comment la kinésine1 reconnaît et interagit avec ses cargos est important pour déterminer son rôle, ainsi que celui de ses cargos, au niveau du fonctionnement des cellules normales et pathologiques. La kinésine1 est un hétérotétramère constitué de deux chaînes lourdes (KHC) et de deux chaînes légères (KLC) toutes deux étant capables de recruter des protéines cargos. L’une des premières protéines cargos à avoir été identifiée est JIP1 (JNK-interacting protein 1) qui est, entre autres: (i) une protéine d’échafaudage pour la voie de signalisation des MAP kinases et (ii) une protéine adaptatrice pour le transport de la protéine précurseur de l’amyloïde (APP) responsable de la maladie d’Alzheimer. Dans les deux cas, JIP1 régule des processus critiques au niveau de la cellule, ce qui en fait une protéine intéressante à étudier. Des premières études ont permis de mieux comprendre comment JIP1 est recrutée et transportée par la kinésine1. Cependant, le détail de l’interaction entre KLC et JIP1 n’est pas encore complètement décrit et donc compris.Objectifs : Mon travail de doctorat vise à caractériser au niveau moléculaire l’interaction entre KLC et JIP1. Pour ce faire, j’avais pour objectifs : 1) de caractériser les domaines d’interaction des deux protéines seules, 2) d’étudier la formation du complexe en solution par des approches biophysiques et 3) de déterminer la structure 3D du complexe par cristallographie.Résultats : Dans un premier temps, j’ai caractérisé le domaine TPR de KLC seul en contribuant entre autres au développement d’une boite à outils moléculaires. J’ai aussi participé à la détermination de deux structures cristallographiques du domaine TPR de KLC1/2 permettant de mettre en évidence la plasticité structurale de la 1ère hélice de ce domaine (Nguyen et al, soumis). Dans un second temps, j’ai mis en place les conditions d’expression et de purification du domaine PTB de JIP1 et mener la caractérisation structurale de ce domaine en solution. Bien que ce domaine de JIP1 ne soit pas nécessaire pour l’interaction avec KLC, j’ai pu étudier l’impact de sa présence au niveau du recrutement par KLC. Finalement, j’ai caractérisé le recrutement de JIP1 par KLC en confirmant tout d’abord un certain nombre d’information sur l’interaction entre le domaine TPR de KLC et la région C-terminale (Cter) de JIP1 au niveau moléculaire. Les nombreux essais de cristallisation que j’ai menés n’ont pas permis d’obtenir des cristaux du complexe KLC:JIP1. J’ai cependant pu cartographier de façon précise la zone d’interaction de JIP1-Cter avec le domaine TPR de KLC en employant les différents outils de KLC disponibles pour déterminer par calorimétrie leur affinité avec JIP1-Cter (Nguyen et al., en préparation).Conclusion : Ainsi, mon travail de doctorat a permis de mieux comprendre 1) la versatilité structurale du domaine TPR de KLC, 2) l’impact du domaine PTB de JIP1 pour son recrutement par KLC et 3) le mode d’interaction de JIP1 par KLC. Sur la base de ces données, je discuterai les bases structurales du mode d’interaction de KLC avec JIP1 et le comparerai à celui de KLC avec les cargos à motif WD, comme SKIP et Alcadéine-α
AbstractKinesins are molecular motors involved in the intracellular transport of many cargos within the cell. Although the motility of kinesins is well understood, the molecular mechanisms underlying cargo recruitment are much less so.Kinesin1 plays various roles in neuronal cells, where it contributes to the spatial and temporal organization of many cellular components. It would play a role in various neurological pathologies, such as Alzheimer's disease. Understanding how kinesin1 recognizes and interacts with its cargos is important to decorticate its role, as well as that of its cargos, in normal and pathological cells. Kinesin1 is a heterotetramer consisting of two heavy chains (KHC) and two light chains (KLC), both of which are capable of recruiting cargo proteins. One of the first cargo proteins to have been identified is JIP1 (JNK-interacting protein 1) which is: (i) a scaffold protein for the signaling pathway of MAP kinases and (ii) an adaptor protein for transporting amyloid precursor protein (APP) responsible for Alzheimer's disease. In both cases, JIP1 regulates critical processes at the cell level, making it an interesting protein to study. Early studies have led to a better understanding of how JIP1 is recruited and transported by kinesin1. However, the detail of the interaction between KLC and JIP1 is not yet fully described and therefore understood.Objectives: My doctoral work aims at characterizing at the molecular level the interaction between KLC and JIP1. To do this, I had the following objectives: 1) to characterize the interaction domains of the two proteins alone, 2) to study the formation of the complex in solution by biophysical approaches, and 3) to determine the 3D structure of the complex by crystallography.Results: Initially, I characterized the TPR domain of KLC alone, contributing among others to the development of a molecular toolbox. I also participated in the determination of two crystallographic structures of the TPR domain of KLC1/2 that highlights the structural plasticity of the first helix of this domain (Nguyen et al, submitted). In a second step, I set up the conditions for the expression and purification of the PTB domain of JIP1 and carry out the structural characterization of this domain in solution. Although this domain of JIP1 is not necessary for interaction with KLC, I studied the impact of its presence on recruitment by KLC. Finally, I characterized the recruitment of JIP1 by KLC by confirming a number of information on the interaction between the KLC-TPR and the C-terminal region (Cter) of JIP1 at the molecular level. The numerous crystallization tests that I carried out did not make it possible to obtain crystals of the KLC: JIP1 complex. However, I was able to precisely map the interaction zone of JIP1-Cter with the KLC-TPR domain using the various KLC tools available by determining by ITC their affinity with JIP1-Cter (Nguyen et al., In preparation ).Conclusion: Thus, my PhD work allowed to better understand 1) the structural versatility of the KLC-TPR domain, 2) the impact of the JIP1-PTB domain for its KLC recruitment, and 3) the interaction mode of JIP1 by KLC . On the basis of these data, I will discuss the structural basis of the mode of binding of KLC with JIP1 and compare it with that of KLC with WD-motif cargo, such as SKIP and Alcadein-α

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Almeida, Michael Aparício de. « Equity research da Air France - KLM ». Master's thesis, Instituto Superior de Economia e Gestão, 2019. http://hdl.handle.net/10400.5/19085.

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Mestrado em Contabilidade, Fiscalidade e Finanças Empresariais
A Air France-KLM (AF-KLM) é a companhia de bandeira da França, é resultado da fusão entre as empresas Air France (francesa) e KLM (holandesa) possuindo dois hubs principais situados em Paris e Schipol. O grupo é atualmente líder da europa em termos de tráfego e tem como objetivo ser uma das maiores companhias à escala global. O trabalho final de mestrado que se segue tem como objetivo principal estimar o valor intrínseco das ações da AF-KLM para 31 de dezembro de 2018. Este projeto é composto por uma revisão bibliográfica onde são analisados os métodos de avaliação possíveis e a partir da qual é definida a metodologia para este mesmo projeto. Foi também feita uma análise em relação ao ambiente macroeconómico, da indústria e especificamente da AF-KLM. De forma a calcular o valor intrínseco procedeu-se à avaliação por fluxos de caixa atualizados baseado em valores de FCFF pelo qual foi determinado um valor intrínseco de 11.33 euros para as ações da AF-KLM para a data de 31 de dezembro de 2018. Este valor sugere que as ações se encontram subvalorizadas e que possuem um potencial de crescimento de 19.55% face ao preço de 9.48 euros registado a 31 de dezembro de 2018. Através da avaliação relativa foram utilizados dois múltiplos, em que o enterprise valueto-EBITDA resultou num preço de 23.5 euros por ação e o price-to-earnings foi igual a 5.3 euros por ação culminando numa média de 14.43 euros por ação que corresponde a um potencial de crescimento de 52.2%.
Air France-KLM (AK-KLM) is the flag carrier of France resulted of the fusion between Air France (french) and KLM (dutch). It has two main hubs located in Paris and Schipol. The group is the current european leader in passenger traffic and aims to be one of the world's best airline companies. The following project aims to estimate the intrinsic value of AF-KLM's stock price as of December 31, 2018. It consists of a literature review where possible evaluation methods are analysed from which the methodology of this project is defined. An analysis was also made of the macroeconomic environment, industry and the company's specifics. In order to estimate the intrinsic value, cash flow discount model based on FCFF values was carried out whereby an intrinsic value of 11.33 euros was determined for AFKLM's shares as of 31 December 2018. This result suggests that shares are undervalued and have a growth potential of 19.55% compared to the closing price of 31 December 2018 (9.48 euros). Through the relative valuation two multiples were used, in which enterprise-value-to-EBITDA resulted in 23.5 euros per share and where the price-toearnings ratio gave a price of 5.3 euros per share, culminating in an average of 14.43 euros per share which corresponds to a growth potential of 52.2%.
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Burger, Daniel. « The KLT relations in unimodular gravity ». Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20989.

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Here we initiate a systematic study of some of the symmetry properties of unimodular gravity, building on much of the known structure of general relativity, and utilizing the powerful technology developed in that context, such as the spinor helicity formal-ism. In particular, we show, up to five-points and tree-level, that the KLT relations of perturbative gravity hold for trace free or unimodular gravity. This work is in conjunction with a paper written with A. Welman, J. Murugan and G.F.R. Ellis (ARXIV: 1511.08517)

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Steinberg, David. « Homological Properties of Standard KLR Modules ». Thesis, University of Oregon, 2017. http://hdl.handle.net/1794/22292.

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Khovanov-Lauda-Rouquier algebras, or KLR algebras, are a family of algebras known to categorify the upper half of the quantized enveloping algebra of a given Lie algebra. In finite type, these algebras come with a family of standard modules, which correspond to PBW bases under this categorification. In this thesis, we show that there are no non-zero homomorphisms between distinct standard modules and that all non-zero endomorphisms of standard modules are injective. We then apply this result to obtain applications to the modular representation theory of KLR algebras. Restricting our attention to finite type A, we are then able to compute explicit projective resolutions of all standard modules. Finally, in finite type A when alpha is a positive root, we let D be the direct sum of all distinct standard modules and compute the algebra structure on Ext(D, D). This dissertation includes unpublished co-authored material.

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Plus de sources

Livres sur le sujet "KL6"

Indonesia. Direktorat Jenderal Pembinaan Pelatihan dan Produktivitas Tenaga Kerja., dir. Studi kelayakan pengembangan KLK Karawang, KLK Bekasi, dan KLK Tangerang sebagai KLK industri. [Jakarta] : Departemen Tenaga Kerja R.I., Direktorat Jenderal Pembinaan Pelatihan dan Produktivitas Tenaga Kerja, 1995.

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Kojadinovic, Jelena. Sedam godina za tri okeana : Kli-Kli. Beograd : Kosmos, 1989.

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Gutfrański, Krzysztof. Kla-man. [Gdańsk] : Instytut Sztuki Wyspa, 2010.

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Thijs, Postma, dir. KLu vliegtuigen. Alkmaar : De Alk, 1987.

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translator, Levine Elihu, dir. Kli Yakar. Brooklyn, NY : Menucha Publishers, 2013.

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Hasni, Hussain. Ummat kli Manen. Karachi, Pakistan : Naunihal Adab, 1992.

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Rifbjerg, Klaus. Den sde kle. Kbenhavn : Information, 1999.

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Siregar, Nazaruddin. Pemetaan BLK/KLK. Jakarta : Departemen Tenaga Kerja dan Transmigrasi, Badan Penelitian, Pengembangan, dan Informasi, Pusat Litbang Ketenagakerjaan, 2006.

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Røed, Helge. Politikk og pensjoner : KLP gjennom 50 år. Oslo : Kommuneforlaget, 1998.

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Arnold, Heinz Ludwig, dir. Kindlers Literatur Lexikon (KLL). Stuttgart : J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0.

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Chapitres de livres sur le sujet "KL6"

Jackson, David. « KLM ». Dans Dynamic Organisations, 215–21. London : Palgrave Macmillan UK, 1997. http://dx.doi.org/10.1007/978-1-349-14169-2_13.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, N. Melnichenko-Koblyuk et al. « KLi[SO4] ». Dans Structure Types. Part 5 : Space Groups (173) P63 - (166) R-3m, 58. Berlin, Heidelberg : Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-46933-9_13.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, N. Melnichenko-Koblyuk et al. « KLi[SO4] ». Dans Structure Types. Part 5 : Space Groups (173) P63 - (166) R-3m, 79. Berlin, Heidelberg : Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-46933-9_34.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, N. Melnichenko-Koblyuk et al. « KLi[SO4] ». Dans Structure Types. Part 5 : Space Groups (173) P63 - (166) R-3m, 54. Berlin, Heidelberg : Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-46933-9_9.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, O. Pavlyuk, I. Savysyuk et S. Stoyko. « KLi[SO4] ». Dans Structure Types. Part 7 : Space Groups (160) R3m - (156) P3m1, 569–70. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-69949-1_211.

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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, O. Pavlyuk, I. Savysyuk et S. Stoyko. « KLi[SO4] ». Dans Structure Types. Part 7 : Space Groups (160) R3m - (156) P3m1, 579. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-69949-1_218.

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Maccone, Claudio. « Maccone third KLT theorem : Asymptotic KLT of GBM ». Dans Mathematical SETI, 585–606. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27437-4_26.

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Montebugnoli, Stelio. « Implementing the KLT ». Dans Searching for Extraterrestrial Intelligence, 275–84. Berlin, Heidelberg : Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13196-7_15.

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Maccone, Claudio. « A simple introduction to the KLT and BAM-KLT ». Dans Mathematical SETI, 411–48. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27437-4_17.

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Maccone, Claudio. « Maccone first KLT theorem : KLT of all timerescaled Brownian motions ». Dans Mathematical SETI, 535–47. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27437-4_22.

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Actes de conférences sur le sujet "KL6"

Lanzarone, Nicola, Valerio Alonzi, Laura Bergantini, Francesco Bianchi, Miriana D’Alessandro, Paola Rottoli, Rosa Metella Refini et al. « Serum and BAL levels of KL6 in chronic hypersensitivity pneumonitis Serum and BAL levels of KL6 in chronic hypersensitivity pneumonitis ». Dans ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa1359.

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Salazar, G., M. Kuwana, M. Wu, RM Estrada-Y-Martin, J. Ying, J. Charles, C. Bellocchi, M. Mayes et S. Assassi. « FRI0363 KL6 and not CCL-18 is a predictor of early progression in systemic sclerosis related interstitial lung disease ». Dans Annual European Congress of Rheumatology, 14–17 June, 2017. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. http://dx.doi.org/10.1136/annrheumdis-2017-eular.5145.

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Wang, Wei, Xianghua Yang, Jiaren Ye, Tandis S. Bidgoli, W. Lynn Watney, Hongtao Zhu et Qingbin Wang. « INFLUENCE OF SYNDEPOSITIONAL VOLCANISM ON OLIGOCENE SANDSTONE DIAGENESIS AND QUALITY : A COMPARISON OF THE BZ34-9 AND KL6 FIELDS IN THE SOUTHERN BOHAI SEA, CHINA ». Dans GSA Annual Meeting in Denver, Colorado, USA - 2016. Geological Society of America, 2016. http://dx.doi.org/10.1130/abs/2016am-286279.

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Winanto, Winanto, Mukhtarus Bahroinuddin, Endro Cahyono et Margaretha Thaliharjanti. « A Dynamic Simulation Assessment for Relocating Flare System into Separated Platform Utilizing Idle Subsea Main Oil line ». Dans SPE/IATMI Asia Pacific Oil & Gas Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/205741-ms.

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Abstract KLB is an offshore platform that consists of production wells and two train gas lift compressors. During well intervention, the KLB operation team must turn off the flaring system due to potential flare radiation of more than 500 BTU/hr-ft2at the working area and gas dispersion more than 50 %-LEL at the flare tip. The relocation of the KLB flaring system to the nearest platform keeps the KLB gas lift compressor operating during this activity. The relocation scenario can maintain the KLB platform production of 700 BOPD. KLA Flowstation is the nearest platform to the KLB. It is separated one kilometer, connected by an idle subsea oil pipeline, but there are no pigging facilities due to limited space at the KLB platform. Therefore, the comprehensive assessment to relocate the KLB flaring system is a) Flare system study using Flare Network software to simulate backpressure and Mach Number at tailpipe in the KLA and KLB flaring system; b). Dynamic transient simulation using Flow Assurance Software to calculate backpressure, liquid hold up, and slugging condition in the flare KO drum; and c). Flare radiation and dispersion study. The initial condition of the idle subsea oil pipeline was full of liquid as the preservation for a pipeline to prevent a further oil spill in case of a leak during the idle condition. The dewatering process for the idle subsea pipeline has been conducted by purging the pipeline utilizes 0.7 MMscfd gas lift with a pressure of 100 psig to displace liquid content to 20 bbl. The transient simulation for gas swapping was conducted at a gas rate of 4.1 MMscfd as the train compressor's flaring condition. The calculated backpressure at the KLB safety valve is 12.3 psig below the required maximum of 30 psig. The calculated liquid surge volume in the Flare KO drum during flaring is 17 bbl and can be handled by surge volume inside the KO drum. The predicted condensation inside the subsea pipeline shows that the maximum operation of the flaring system is limited to 30 days. The radiation and gas dispersion to the nearest facility is within a safe limit. The KLB teams successfully conducted the relocation of the flaring system from the KLB platform to the KLA platform. The result was no interruption of production, no risk of radiation, and no potential explosion during a well intervention. Experience in the last two activities has confirmed that this method can prevent revenue loss of 19 billion rupiahs. This study has initiated a new engineering standard and best practice for flaring systems as opposed to the current practice which states that the flare location shall be at the same location as the production facilities with no pocket piping in between. This study and field experience have proved that the flaring system can be located on a different platform by conducting engineering assessments to ensure process and process safety criteria are within Company and International Standard.

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Tjahyadi, Riza, et I. Made Suyasa. « KLX/KLY Reservoir Management Using Integrated Asset Modeling, Case Study ». Dans SPE Asia Pacific Oil and Gas Conference and Exhibition. Society of Petroleum Engineers, 2004. http://dx.doi.org/10.2118/88602-ms.

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Passemar, Emilie. « Precision SM calculations and theoretical interests beyond the SM in Kl2 and Kl3 decays ». Dans 2009 KAON International Conference. Trieste, Italy : Sissa Medialab, 2010. http://dx.doi.org/10.22323/1.083.0024.

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Harshvardhan, Adam Fidel, Nancy M. Amato et Lawrence Rauchwerger. « KLA ». Dans the 23rd international conference. New York, New York, USA : ACM Press, 2014. http://dx.doi.org/10.1145/2628071.2628091.

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Cousins, Benjamin, et Santosh Vempala. « Bypassing KLS ». Dans STOC '15 : Symposium on Theory of Computing. New York, NY, USA : ACM, 2015. http://dx.doi.org/10.1145/2746539.2746563.

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Leino, Katri, Antti Oulasvirta et Mikko Kurimo. « RL-KLM ». Dans IUI '19 : 24th International Conference on Intelligent User Interfaces. New York, NY, USA : ACM, 2019. http://dx.doi.org/10.1145/3301275.3302285.

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Yang, Shuo, Gaopan Kong et Zan Wu. « Experimental Study of Gas-Liquid Mass Transfer in a Rectangular Microchannel by Digital Image Analysis Method ». Dans ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-69095.

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Abstract Study of mass transfer in microchannels is indispensable for the design of microreactors. Gas-phase volume monitoring method has been widely used to study the mass transfer process. When using this method, bubble length was measured in most studies to calculate the bubble volume by assuming a symmetrical bubble shape. Therefore, this method is not suitable for asymmetric bubbles. The present study focuses on the mass transfer of CO2 bubbles in a flat rectangular microchannel by using the method of digital image analysis (DIA), especially for deformed bubbles. The dynamics of gas-liquid flow at different volumetric flow rates were observed by a high-speed recording system. Flow patterns were mapped and scaling laws were given for bubble size and bubble velocity. The results showed that the bubble volume increases as gas flow rate increases, while decreases as liquid flow rate increases. It can be explained by the bubble breakup mechanism. Besides, the bubble velocity increases as gas and liquid flow rates increase. The mass transfer of CO2 from bubbles to liquid slugs was quantitatively characterized by volumetric mass transfer coefficient kLa. The results showed that kLa and kL increase with increasing of superficial gas and liquid velocities. The same tendencies can be found in the literature. Finally, new mass transfer correlations were proposed. Predictions from the correlations showed a good agreement with the experimental data.

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Rapports d'organisations sur le sujet "KL6"

Rodriguez-Burgos, Rosa E. Targeted Analysis of KLF6/KLF6-SV1 Regulating Pathways in Prostrate Cancer Development and Metastasis. Fort Belvoir, VA : Defense Technical Information Center, septembre 2010. http://dx.doi.org/10.21236/ada542531.

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Rodriguez-Burgos, Rosa. Targeted Analysis of KLF6/KLF6-SV1 Regulating Pathways in Prostate Cancer Development and Metastasis. Fort Belvoir, VA : Defense Technical Information Center, septembre 2011. http://dx.doi.org/10.21236/ada551370.

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Mevarech, Moshe, Jeremy Bruenn et Yigal Koltin. Virus Encoded Toxin of the Corn Smut Ustilago Maydis - Isolation of Receptors and Mapping Functional Domains. United States Department of Agriculture, septembre 1995. http://dx.doi.org/10.32747/1995.7613022.bard.

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Ustilago maydis is a fungal pathogen of maize. Some strains of U. maydis encode secreted polypeptide toxins capable of killing other susceptible strains of U. maydis. Resistance to the toxins is conferred by recessive nuclear genes. The toxins are encoded by genomic segments of resident double-strande RNA viruses. The best characterized toxin, KP6, is composed of two polypeptides, a and b, which are not covalently linked. It is encoded by P6M2 dsRNA, which has been cloned, sequenced and expressed in a variety of systems. In this study we have shown that the toxin acts on the membranes of sensitive cells and that both polypeptides are required for toxin activity. The toxin has been shown to function by creating new pores in the cell membrane and disrupting ion fluxes. The experiments performed on artificial phospholipid bilayers indicated that KP6 forms large voltage-independent, cation-selective channels. Experiments leading to the resolution of structure-function relationship of the toxin by in vitro analysis have been initiated. During the course of this research the collaboration also yielded X-ray diffracion data of the crystallized a polypeptide. The effect of the toxin on the pathogen has been shown to be receptor-mediated. A potential receptor protein, identified in membrane fractions of sensitive cells, was subjected to tryptic hydrolysis followed by amino-acid analysis. The peptides obtained were used to isolate a cDNA fragment by reverse PCR, which showed 30% sequence homology to the human HLA protein. Analysis of other toxins secreted by U. maydis, KP1 and KP4, have demonstrated that, unlike KP6, they are composed of a single polypeptide. Finally, KP6 has been expressed in transgenic tobacco plants, indicating that accurate processing by Kex2p-like activity occurs in plants as well. Using tobacco as a model system, we determined that active antifungal toxins can be synthesized and targeted to the outside of transgenic plant cells. If this methodology can be applied to other agronomically crop species, then U. maydis toxins may provide a novel means for biological control of pathogenic fungi.

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McClenaghan, M. B., I. M. Kjarsgaard et B. A. Kjarsgaard. Indicator mineralogy of the KL-01 and KL-22 kimberlites, Lake Timiskaming kimberlite field, Ontario. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2008. http://dx.doi.org/10.4095/225398.

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Ryd, Anders. Evidence for the Flavor Changing Neutral Current Decays B->Kll and B->K*ll. Office of Scientific and Technical Information (OSTI), juillet 2002. http://dx.doi.org/10.2172/799971.

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Campbell, Myron, et Monica Tecchio. Proposal to Participate in J-Parc KL Experiment. Office of Scientific and Technical Information (OSTI), février 2013. http://dx.doi.org/10.2172/1061477.

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Carlson, Matthew D., Timothy A. Shedd et Gerald E. Kashmerick. Thermodynamic Analysis and Comparison of the K6 Cycle. Warrendale, PA : SAE International, novembre 2011. http://dx.doi.org/10.4271/2011-32-0600.

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Sadamoto, Masayoshi. Search for the Decay KL ->pi0 mu+ mu-. Office of Scientific and Technical Information (OSTI), février 1999. http://dx.doi.org/10.2172/1421477.

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Beuther, H. Sub-Arcsecond Sub-mm Continuum Observations of Orion-KL. Office of Scientific and Technical Information (OSTI), juin 2004. http://dx.doi.org/10.2172/827013.

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Granger, Trinity D., Victoria A. Henry et Stanley Latesky. Separation of Lanthanide Ions with Kl?ui Ligand Resin. Office of Scientific and Technical Information (OSTI), juillet 2007. http://dx.doi.org/10.2172/1029442.

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