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Pendyurina, Lyudmila. « Issues of personal self-realization in the concept of education by J. Krishnamurti ». SHS Web of Conferences 70 (2019) : 05007. http://dx.doi.org/10.1051/shsconf/20197005007.
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The article discusses the problems of individual development and self-development, put forward in the teachings of the Indian thinker J. Krishnamurti, explores the specifics of the humanistic approach in the modern cultural educational space. The author analyzes the content of the cultural-like and cultural-creation paradigm of J. Krishnamurti’s education and upbringing, reveals its main ideas and provisions, traces the ways of forming psychological and mental attitudes that have internal constant value. The article gives an analysis of the projective pedagogical and educational decisions of J. Krishnamurti, allowing you to change the idea of education as an information-cognitive process and remove the narrowly focused scientific and utilitarian principles of its construction.
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Islam, Merina. « J Krishnamurti’s Insight on Meditation ». Tattva - Journal of Philosophy 8, no 1 (1 janvier 2016) : 19–26. http://dx.doi.org/10.12726/tjp.15.2.
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J. Krishnamurti, whose life and teachings spanned the greater part of the 20th Century, is regarded by many as one who has had the most profound impact on human consciousness in modern times. He talked of the things that concern all of us in our everyday life: the problems of living in modern society, the individual’s search for security, and the need for human beings to free themselves from their inner burdens of violence, fear and sorrow. Meditation, according to Krishnamurti, is not the popular tranquilizer that most people call to mind, but an attempt to see if there is an end to knowledge, therefore freedom from the known. What Krishnamurti considers meditation is along the lines of insight meditation or jyana yoga. Meditation is not a means to an end; there is no end, no arrival; it is a movement in time and out of time. Every system and method binds thought to time, but choice less awareness of every thought and feeling, as well as an understanding of their motives, their mechanism, allowing them to blossom, is the beginning of meditation. This paper is an attempt to discuss J. Krishnamurti’s insight on what meditation is and how to practice it.
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Limbasiya, Nailesh. « Book review : Jiddu Krishnamurti, J. Krishnamurti on Education ». Journal of Human Values 28, no 3 (4 août 2022) : 271–75. http://dx.doi.org/10.1177/09716858221093445.
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Srinivasan, T. S. « J. Krishnamurti and the Practice of Management ». Vision : The Journal of Business Perspective 4, no 1_suppl (janvier 2000) : 52–56. http://dx.doi.org/10.1177/09722629000040s107.
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Berghout, Amina. « Education and the Significance of Life by Jiddu Krishnamurti ». Central European Journal of Educational Research 4, no 1 (27 juin 2022) : 166–69. http://dx.doi.org/10.37441/cejer/2022/4/1/10681.
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Muñiz Cruz, Néstor de Jesús. « La educación y el significado de la vida ». Miscelánea Filosófica αρχή Revista Electrónica 1, no 3 (10 avril 2018) : 13–14. http://dx.doi.org/10.31644/mfarchere_v.1;n.3/18-a02.
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La educación forma en nosotros una nueva perspectiva sobre la vida, el cómo desarrollarnos en ella, nos forma con códigos de eticidad, etc. La vida es de suma importancia ya que en ella nos podemos manifestar como personas en la realidad. Es decir, tenemos la plena libertad de conocer, de aprender y dar ese conocimiento aprendido, el significado de la vida, desde mi perspectiva y de la de Krishnamurti es formar en la libertad. J. Krishnamurti en su obra “la educación y el significado de la vida” nos muestra un panorama amplio sobre la problemática que existe en la sociedad postmoderna, a lo cual, daré algunos puntos importantes: La liberación de lo religioso; para él, el alumno debe de quitarse esos pensamientos religiosos que simplemente atarían su proceso de estudio. ¿De que qué liberación nos habla? Precisamente de liberarse de creencias, ritos, falsas esperanzas y temores que simplemente coaccionan su libertad y su voluntad.
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Quirós Rodríguez, Rafael. « S. Patwardhan & ; J. Krishnamurti : Hindu Women and the Guru-Shishya Relationship ». Indialogs 3, Violences (16 avril 2016) : 169. http://dx.doi.org/10.5565/rev/indialogs.54.
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Dewhurst, David. « Awareness of mind : A discussion of the Krishnamurti schools in India ». Educational Philosophy and Theory 26, no 2 (janvier 1994) : 16–32. http://dx.doi.org/10.1111/j.1469-5812.1994.tb00204.x.
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Edwards, Stephen Edwards, et Jeffrey Dufour. « Human Psychology and the Concept of God in Indian Society ». International Journal of Social Science Research and Review 3, no 4 (9 décembre 2020) : 1–8. http://dx.doi.org/10.47814/ijssrr.v3i4.51.
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The concept of God in human mind has been and will always be a diversified concept. To understand God one has to travel through his mind and its contents. The centuries of inheritance have cemented the beliefs, on which we stand today. The concept of God is different for every human but to understand the whole concept of God one has to put his inherited knowledge on bay and look what he perceives. As J. Krishnamurti says- We have to completely come out of our psychological conditioning only then there is a possibility of understanding the immense named as God. Since, primitive time till today’s modern world this one word ‘God’ has played a major role in human living. It has travelled through the ages in human mind and to clearly understand this concept of God we have to look at our journey as mankind, without this neither we should accept nor reject the concept of God.
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Shulman, D. « Bh. Krishnamurti and J. P. L. Gwynn : A grammar of Modern Telugu. xxii, 459 pp. Delhi : Oxford University Press, 1985 [pub. 1986]. £25. » Bulletin of the School of Oriental and African Studies 52, no 1 (février 1989) : 162–63. http://dx.doi.org/10.1017/s0041977x00023508.
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Tuite, Kevin. « Dimensions of Sociolinguistics in South Asia : Papers in Memory of Gerald B. Kelley.Edward J. Dimrock, Jr., Braj B. Kachru, and Bh. Krishnamurti, eds ». American Anthropologist 97, no 2 (juin 1995) : 400–401. http://dx.doi.org/10.1525/aa.1995.97.2.02a00590.
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Ferrer, Albert. « Ethics within a spiritual/metaphysical world view towards integral Value-Based education : J. Krishnamurti and theosophy at the junction of the west and the east ». GYANODAYA - The Journal of Progressive Education 11, no 1 (2018) : 30. http://dx.doi.org/10.5958/2229-4422.2018.00006.3.
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STOCCHINO, ALESSANDRO. « Self-sustained double-diffusive interleaving ». Journal of Fluid Mechanics 662 (6 septembre 2010) : 384–97. http://dx.doi.org/10.1017/s0022112010003253.
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The formation and evolution of double-diffusive interleaving is experimentally investigated with the purpose of analysing the influence of the convective flow structures, at different scales, on the mean flow. Recently, Krishnamurti (J. Fluid Mech., vol. 558, 2006, p. 113) has shown that, in the case of a continuous stratification experiment, the Reynolds stresses, due to convective flow patches, are able to vertically transport horizontal momentum, maintaining the mean flow. This mechanism is similar to the turbulent wind observed in thermal convection. In this study, the interleaving is produced using the classical set-up of Ruddick & Turner (Deep-Sea Res., vol. 558, 1979, p. 903). The dam-break experiments better resemble the case of oceanic fronts, where interleaving is commonly observed. The flow structures are investigated by measuring the two-dimensional flow fields using the particle image velocimetry technique. The resulting two-dimensional vector fields reveal complex fine-scale flow structures, and convective patterns are observed inside the finger-favourable layers. Vortical structures at scales comparable with the layer thickness are embedded in these regions and seem to be responsible for sustaining the horizontal mean flow against the viscous dissipations, especially in a region close to the layer nose. A spectral analysis of the flow fields suggest that the energy balance is governed by an inverse energy cascade, which implies a transfer of energy from the smaller scales to the larger scales (mean flow).
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MONKHOUSE, W. S. « Textbook of Anatomy. By R. Kanagasuntheram, P. Sivanandasigham and A. Krishnamurti. (Pp. xvi+695 ; illustrated ; f20 paperback ; ISBN 0 86311 652 3.) London : Sangam Books. 1996. » Journal of Anatomy 192, no 3 (avril 1998) : 473–76. http://dx.doi.org/10.1046/j.1469-7580.1998.192304736.x.
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Pandey, Parth Sarthi. « J. Krishnamurti's Right Education ». Educational Quest- An International Journal of Education and Applied Social Sciences 4, no 3 (2013) : 207. http://dx.doi.org/10.5958/j.2230-7311.4.3.020.
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Kneupper, Theodore L. « J. Krishnamurti's Critique of Religion ». Journal of Indian Philosophy and Religion 17 (2012) : 3–37. http://dx.doi.org/10.5840/jipr2012171.
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Pakhomov, Sergey. « The transformation of classical Tantra in the modern Neotantric movement (on the example of Russia) ». St. Tikhons' University Review 110 (21 décembre 2023) : 81–102. http://dx.doi.org/10.15382/sturi2023110.81-102.
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The article reflects on the transformations that classical Tantra has undergone in the West and in Russia in the 20th – 21st centuries. The basis for the image of Tantra in the Western imagination was the model of «non-dual» Shaiva-Shakta Tantrism. The first serious interpretation and exegesis of Tantra was provided by J. Woodroffe (1865–1936). In parallel with him, the first popularizer of the new Tantra, P. Bernard (1875–1955), worked in the United States. He paid great attention to the themes of love, body and sexuality. But the soil for Neotantra was formed later, and the New Age and “sexual revolution” became its main ingredients. The first Neotantrist should be considered the Indian guru Osho Rajneesh (1931–1990). In Osho’s sermons, classical tantra was combined with Zen Buddhism, Taoism, Western psychotherapy, the teachings of Gurdjieff and Krishnamurti. Osho taught his students spontaneity, naturalness, totality, rebellion against the “slavery of the mind”. Many Neotantric teachers popular in Russia are students of Osho. The arrival of Swami Virato Nostradamus (1938–2013) in 1992 can be considered the beginning of the spread of Tantra in Russia. Among the well-known domestic Neotantric teachers are L. Teternikov, A. Lapin, P. Ostrikov, S. Slyusarev, A. Shelyakov, A. Lyubarsky, S. Knyazev and others. The article analyzes the views of Russian Neotantrists on human nature, their reflection on Tantra, attitude to yoga, religion, women, sexuality. In general, these views are dependent on Osho and his disciples. There are some similarities between Neotantra and classical Tantra (eg., syncretism, practicality, interest in the concept of energy, etc.), although the context of these traits should always be considered. There are more differences between them. In Neotantra we see: rejection of religiosity; declining value of mentoring; rejection of concepts important for classical Tantra (moksha, karma, samsara, etc.) or their remaking; emphasizing the importance of sexuality; absence of sacred texts and sacred language; psychologization. Neotantra is gradually becoming an increasingly organic part of the westernized global world.
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P, Pandiyarasa, et Ravikumar A. « Koshas in the Human Body ». International Research Journal of Tamil 4, no 4 (19 octobre 2022) : 408–11. http://dx.doi.org/10.34256/irjt22454.
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Gosas are very necessary for the growth of the body. Minerals are formed in the body through this kosha. These are the basic materials for the production of body parts and body production. It can be known that the body is made up of pancha kosa and these minerals are the raw materials for the creation of human race when male and female are conceived. Annamaya kosa is the basic kosa of the body and these are called food body. This food gives the body the necessary energy. The actions of the inner self are visible on the face. Annamaya Kosam makes this clear to us every day through our face. Pranamaya kosham is very helpful for the development of Annamaya kosham. These are known as wind body. This kosham can also be said to be the energy of the body. After rising in the soil of a child, the body experiences Pranamaya kosham. The body is aware. Next is the manon medhosam and the awareness kosam which works together with the pranamaya kosam. These are very helpful in the development of life. There are eight types of yoga for movement of the kosham. These tips are very helpful in implementing them. Through this we can know that the Vijyanmaya Kosam is activated. Therefore, the instinctive state is the Vijyanmaya Kosam that surrounds the body. This is the state of self-awareness according to philosopher J. Krishnamurti says, "Who am I?" The thought should occur to every human being, then the Anandamaya Kosha starts working in this body. This energy can be seen in the body. Thus, through the Kosha, the body, soul and soul work in the same straight line for development in human life and the body passes the state of peace and reaches the state of samadhi. Therefore, the function of the Kosha in the human body is very plays an important role.
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Chaukar, Himani. « Constructing Indian Philosophical Antidotes for the Cardinal Fallacies ». International Journal of Philosophical Practice 7, no 1 (2021) : 41–60. http://dx.doi.org/10.5840/ijpp2021714.
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Philosophy in general is defined as the theory or attitude that acts as a guiding principle for an enriched life. Since time immemorial, many notable scholars have guided humanity towards leading a nourished and fulfilling life through their philosophical preaching and writings and were used by as benchmarks many in their day-to-day life. With the passage of time, Philosophy has taken strides and has evolved majorly to touch the human race irrespective of their caste, race, color, creed, region, etc. and is presently a major contributor for a better world. An extension of this subject is the Logic Based Therapy (LBT) which is slowly but surely is gaining grounds in today's world and is being used as a proficient tool to enhance the value of an individual's life by tackling his erroneous thoughts, also called fallacies in philosophical terms and to bring him on track towards a better existence. Hence, Logic-Based-Therapy (LBT) is fundamentally a philosophical therapy as it makes use of the philosophical wisdom from antiquity, transforming them into antidotes and ultimately using these potent antidotes to treat the cardinal fallacies. Till date, LBT has been the domain of Western philosophical antidotes but Indian philosophy also has an immense plethora of insights to offer in this area. The Sanskrit word for Philosophy is 'Darshan' which means 'Vision'. Indian Philosophy is considered as the vision of the wise and learned people and it becomes even more relevant as it embeds the potential to make our lives qualitatively better. Hence, the ultimate aim of Indian Philosophy is to be a guide for humanity and lead them towards the path of leading a 'good and meaningful life' whilst overcoming our fallacies and issues in our daily lives mainly through the preaching and writings of some great Indian philosophers. The current paper is an attempt at constructing such useful Indian Philosophical antidotes from the ideas of some of the most prominent contemporary Indian Philosophers like Rabindranath Tagore, Swami Vivekananda, Mahatma Gandhi, Lokamanya Tilak, Gopal Agarkar and J. Krishnamurti. The main focus being the key aspects of these philosopher's ideas that are relevant in addressing the cardinal fallacies and strengthening/promoting the corresponding transcendental virtues.
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Samal, Himansusekhar. « Post-Pandemic Human Predicament : J. Krishnamurti’s Philosophical insight ». Research Journal of Philosophy & ; Social Sciences 47, no 2 (31 décembre 2021) : 199–206. http://dx.doi.org/10.31995/rjpsss.2021v47i02.26.
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Naveen Kumar, V., et Madhuram Krishnamurthy. « Probiotics in Caries Prevention ». Journal of Contemporary Dental Practice 19, no 2 (2018) : 123–24. http://dx.doi.org/10.5005/jp-journals-10024-2224.
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Cochran, John C. « The Stille Reaction (Farina, Vittorio ; Krishnamurthy, Venkat ; Scott, William J.) ». Journal of Chemical Education 76, no 10 (octobre 1999) : 1344. http://dx.doi.org/10.1021/ed076p1344.
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Krishnamurthy, Gautham, Harjeet Singh et Rajinder Singh. « Successful Conservative Management of Spontaneous Antegrade Migration of Feeding Jejunostomy ». Euroasian Journal of Hepato-Gastroenterology 7, no 1 (2017) : 84–86. http://dx.doi.org/10.5005/jp-journals-10018-1219.
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ABSTRACT Successful conservative management of spontaneous antegrade migration of feeding jejunostomy of a patient with dysphagia due to carcinoma of nasopharynx is reported. How to cite this article: Krishnamurthy G, Pandit N, Singh H, Singh R. Successful Conservative Management of Spontaneous Antegrade Migration of Feeding Jejunostomy. Euroasian J Hepato-Gastroenterol 2017;7(1):84-86.
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Smitha, SG, Sakshi Bhardwaj, BV Chandregowda et Thejasvi Krishnamurthy. « Chondroid Syringoma of Nose ». An International Journal Clinical Rhinology 5, no 1 (2012) : 30–31. http://dx.doi.org/10.5005/jp-journals-10013-1113.
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ABSTRACT Chondroid Syringoma is a rare cutaneous tumor which usually arises in middle age with predilection for head and neck region. We report a case of chondroid syringoma of nose with review of literature. How to cite this article Chandregowda BV, Smitha SG, Bhardwaj S, Krishnamurthy T. Chondroid Syringoma of Nose. Clin Rhinol Int J 2012;5(1):30-31.
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Kumar, Vijay, Kusuma Vijay Kumar et KH Krishnamurthy. « A Rare Case Report of Microperforate Hymen with Difficulty in Penetration ». Journal of SAFOMS 2, no 2 (2014) : 97–98. http://dx.doi.org/10.5005/jp-journals-10032-1052.
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ABSTRACT A rare case of 26-year-old women with microperforate hymen reported a difficulty in intercourse. Hymenectomy is the surgical treatment for imperforate hymen and microperforate hymen. A knife or electrocautery can be used to excise hymenal tissue. How to cite this article Kumar V, Kumar KV, Krishnamurthy KH, Kumar R. A Rare Case Report of Microperforate Hymen with Difficulty in Penetration. J South Asian Feder Menopause Soc 2014;2(2):97-98.
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Pinto, Ana Cristina Silva, Fernando Ferreira Costa, Sandra Fatima Menosi Gualandro, Patricia Belintani Blum Fonseca, Carolina Tosin Bueno et Rodolfo D. Cançado. « Burden of Sickle Cell Disease : A Brazilian Societal Perspective Analysis ». Blood 136, Supplement 1 (5 novembre 2020) : 10–11. http://dx.doi.org/10.1182/blood-2020-136168.
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Introduction: Sickle cell disease (SCD) is a group of inherited disorders that shorten life expectancy. It is estimated that 300,000 children are born with the disease worldwide each year [1,2]. In Brazil is it estimated that 3,500 children are born with SCD each year [3]. The SCD is a multisystem disorder that leads to several complications (acute and chronic) including vaso-occlusive crisis [1,4]. SCD patients experience increase morbidity and mortality, the implications of which are known to impacts the whole society [2]. Although there is some knowledge about the clinical impacts of SCD, little is known about the societal costs. Due to the limited available, to the best of our knowledge there are no similar studies which have been conducted and published. The aim of this study is to estimate SCD societal costs based on a burden of disease model, utilizing the Brazilian societal perspective. Material and Methods: A burden of disease model (Figure 1) was built considering direct medical costs to adults and children and indirect costs, taking into account lost wages due to SCD related morbidity and death. Direct costs were estimated using a bottom-up strategy and micro-costing method, and indirect costs were estimated using a prevalence method. Disability-adjusted life years (DALYs) were calculated from the sum of years of life lost and disability. The rate and duration of SCD related complications (including death) was calculated using information from a Brazilian governmental healthcare public database (DATASUS). The prevalence of each complication was determined by literature data or medical experts. It is important to point that there is some uncertainty around the prevalence estimates. Direct costs for complications were captured from the Brazilian public healthcare system table of procedures and medications (SIGTAP). Indirect costs attributed to productivity loss were calculated using the human capital method. All values were reported in 2020 Brazilian real (BRL). Results: Considering a prevalence of 23.9 cases per 100,000 (50,000 patients in 2018) and a probability of death of 1.11% (560 deaths in 2018), the annual total SCD cost in Brazil was estimated at 1,519,473,501 BRL. Table 1 shows the contribution of the direct and indirect costs to the total cost for the SCD population in Brazil. Further, results were stratified by children and adults (56% and 44%, respectively). Indirect cost was the main driver of disease burden, estimated at 1,128,355,824 BRL. Approximately 40,829 DALYs were lost by SCD patients in 2018 (22,750 and 18,079 among adults and children, respectively). Direct medical costs represented 25.7% of total costs and were estimated at 391,117,677 BRL. Provision of standard of care was the main driver of direct costs in both populations (157,521,597 BRL for adults and 100,133,575 BRL for children). Chronic complication management was shown to be more expensive than acute complication management among adults, while the opposite was observed for children. Vaso-occlusive crisis was the acute complication most frequently observed in available literature and according to medical experts (75.0% among adults and 59.5% among children). Acute chest syndrome had the highest disability weight (0.33). Considering chronic complications, calculous chronic cholecystitis was considered the most frequent among adults (62.0%) and renal abnormalities (without failure) among children (20.0%). Conclusion: SCD patients generate a high economic burden for the Brazilian society greater than one point five billion BRL per year. Most of the cost is related to indirect burden due to increased mortality and morbidity. Investments in technologies and therapies that can decrease the impact of SCD on patients' lives by reducing morbidity and/or mortality are necessary. References: 1. Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, et al. Sickle cell disease. Nat Rev. 2018 Jun 15;4(1):18010. 2. Mburu J, Odame I. Sickle cell disease : Reducing the global disease burden. 2019;41(February):82-8. 3. Carneiro-Proietti ABF, Kelly S, Miranda Teixeira C, Sabino EC, Alencar CS, Capuani L, et al. Clinical and genetic ancestry profile of a large multi-centre sickle cell disease cohort in Brazil. Br J Haematol. 2018 Sep;182(6):895-908. 4. Piel FB, Steinberg MH, Rees DC. Sickle Cell Disease. Longo DL, editor. N Engl J Med. 2017 Apr 20;376(16):1561-73. Figure 1 Disclosures Pinto: Novartis: Consultancy. Costa:Novartis: Consultancy. Gualandro:Novartis: Consultancy. Fonseca:Novartis: Consultancy. Bueno:Novartis: Current Employment. Cançado:Novartis: Consultancy.
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Krishnamurthy, Gautham, Hemanth Kumar, Rinki Das et Rajesh Gupta. « Isolated Duodenal Trauma following Cricket Ball Injury ». Journal of Postgraduate Medicine, Education and Research 49, no 4 (2015) : 213–15. http://dx.doi.org/10.5005/jp-journals-10028-1179.
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ABSTRACT A fifteen years old boy presented to the emergency department with blunt trauma abdomen following cricket ball injury. At the time of presentation, patient was hemodynamically stable with diffuse abdominal tenderness and right hypochondrial guarding. On exploratory laparotomy, he was found to have isolated duodenal laceration and underwent pancreas preserving total duodenectomy with ampullojejunostomy. In the postoperative period, patient developed fever with respiratory tract infection and eventually succumbed to multiorgan dysfunction. To the best of our knowledge, this is the first case report describing isolated duodenal injury resulting from blunt abdominal trauma due to cricket ball. How to cite this article Krishnamurthy G, Kumar H, Das R, Gupta R. Isolated Duodenal Trauma following Cricket Ball Injury. J Postgrad Med Edu Res 2015;49(4):213-215.
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Hymes, Dell. « J. A. Fishman, A. Tabouret-Keller, M. Clyne, B. Krishnamurti, and M. Abdulaziz (eds.), The Fergusonian impact, in honor of Charles A. Ferguson on the occasion of his 65th birthday. Vol. 1 : From phonology to society. Vol. 2 : Sociolinguistics and the sociology of language. Berlin and New York : Mouton de Gruyter, 1986. Pp. xv + 545 ; xv + 598. » Language in Society 18, no 2 (juin 1989) : 267–69. http://dx.doi.org/10.1017/s0047404500013531.
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Denise Blanchard-Boehm, R. « Water for Texas by Jim Norwine, John R. Giardino, and Sushma Krishnamurthy, eds ». Professional Geographer 58, no 3 (août 2006) : 362–65. http://dx.doi.org/10.1111/j.1467-9272.2006.00573_4.x.
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Minh, Pham Thi, Bui Thi Tuyet, Tran Thi Thu Thao et Le Thi Thu Hang. « Application of ensemble Kalman filter in WRF model to forecast rainfall on monsoon onset period in South Vietnam ». VIETNAM JOURNAL OF EARTH SCIENCES 40, no 4 (18 septembre 2018) : 367–94. http://dx.doi.org/10.15625/0866-7187/40/4/13134.
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This paper presents some results of rainfall forecast in the monsoon onset period in South Vietnam, with the use of ensemble Kalman filter to assimilate observation data into the initial field of the model. The study of rainfall forecasts are experimented at the time of Southern monsoon outbreaks for 3 years (2005, 2008 and 2009), corresponding to 18 cases. In each case, there are five trials, including satellite wind data assimilation, upper-air sounding data assimilation, mixed data (satellite wind+upper-air sounding data) assimilation and two controlled trials (one single predictive test and one multi-physical ensemble prediction), which is equivalent to 85 forecasts for one trial. Based on the statistical evaluation of 36 samples (18 meteorological stations and 18 trials), the results show that Kalman filter assimilates satellite wind data to forecast well rainfall at 48 hours and 72 hours ranges. With 24 hour forecasting period, upper-air sounding data assimilation and mixed data assimilation experiments predicted better rainfall than non-assimilation tests. The results of the assessment based on the phase prediction indicators also show that the ensemble Kalman filter assimilating satellite wind data and mixed data sets improve the rain forecasting capability of the model at 48 hours and 72 hour ranges, while the upper-air sounding data assimilation test produces satisfactory results at the 72 hour forecast range, and the multi-physical ensemble test predicted good rainfall at 24 hour and 48 hour forecasts. The results of this research initially lead to a new research approach, Kalman Filter Application that assimilates the existing observation data into input data of the model that can improve the quality of rainfall forecast in Southern Vietnam and overall country in general.References Bui Minh Tuan, Nguyen Minh Truong, 2013. Determining the onset indexes for the summer monsoon over southern Vietnam using numerical model with reanalysis data. VNU Journal of Science, 29(1S), 187-195.Charney J.G., 1955. The use of the primitive equations of motion in numerical prediction, Tellus, 7, 22.Cong Thanh, Tran Tan Tien, Nguyen Tien Toan, 2015. Assessing prediction of rainfall over Quang Ngai area of Vietnam from 1 to 2 day terms. VNU Journal of Science, 31(3S), 231-237.Courtier P., Talagrand O., 1987. Variational assimilation of meteorological observations with the adjoint vorticity equations, Part II, Numerical results. Quart. J. Roy. Meteor. Soc., 113, 1329.Daley R., 1991. Atmospheric data analysis. Cambridge University Press, Cambridge.Elementi M., Marsigli C., Paccagnella T., 2005. High resolution forecast of heavy precipitation with Lokal Modell: analysis of two case studies in the Alpine area. Natural Hazards and Earth System Sciences, 5, 593-602.Fasullo J. and Webster P.J., 2003. 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Soc., 131C, 3269-3289.Hunt B.R., Kostelich E., Szunyogh I., 2007. Efficient data assimilation for spatiotemporal chaos: a local ensemble transform Kalman filter. Physica D., 230, 112-126.Kalnay E., 2003. Atmospheric modeling, data assimilation and predictability. Cambridge University Press, 181.Kalnay et al., 2008. A local ensemble transform Kalman filter data assimilation system for the NCEP global model. Tellus A, 60(1), 113-130.Kato T., Aranami K., 2009. Formation Factors of 2004 Niigata-Fukushima and Fukui Heavy Rainfalls and Problems in the Predictions using a Cloud-Resolving Model. SOLA. 10, doi:10.2151/sola.Kieu C.Q., 2010. Estimation of Model Error in the Kalman Filter by Perturbed Forcing. VNU Journal of Science, Natural Sciences and Technology, 26(3S), 310-316.Kieu C.Q., 2011. Overview of the Ensemble Kalman Filter and Its Application to the Weather Research and Forecasting (WRF) model. VNU Journal of Science, Natural Sciences and Technology, 27(1S), 17-28.Kieu C.Q., Truong N.M., Mai H.T., and Ngo Duc T., 2012. Sensitivity of the Track and Intensity Forecasts of Typhoon Megi (2010) to Satellite-Derived Atmosphere Motion Vectors with the Ensenble Kalman filter. J. Atmos. Oceanic Technol., 29, 1794-1810.Kieu Thi Xin, 2005. Study on large-scale rainfall forecast by modern technology for flood prevention in Vietnam. State-level independent scientific and technological briefing report, 121-151.Kieu Thi Xin, Vu Thanh Hang, Le Duc, Nguyen Manh Linh, 2013. Climate simulation in Vietnam using regional climate nonhydrostatic NHRCM and hydrostatic RegCM models. Vietnam National University, Hanoi. Journal of Natural sciences and technology, 29(2S), 243-25.Krishnamurti T.N., Bounoa L., 1996. An introduction to numerical weather prediction techniques. CRC Press, Boca Raton, FA.Lau K.M., Yang S., 1997. Climatology and interannual variability of the Southeast Asian summer monsoon. 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Local ensemble transform Kalman filtering with an AGCM at a T159/L48 resolution. Mon. Wea. Rev., 135, 3841-3861.Nguyen Khanh Van, Tong Phuc Tuan, Vuong Van Vu, Nguyen Manh Ha, 2013. The heavy rain differences based on topo-geographical analyse at Coastal Central Region, from Thanh Hoa to Khanh Hoa. J. Sciences of the Earth, 35, 301-309.Nguyen Minh Truong, Bui Minh Tuan, 2013. A case study on summer monsoon onset prediction for southern Vietnam in 2012 using the RAMS model. VNU Journal of Science, 29(1S), 179-186.Phillips N.A., 1960b. Numerical weather prediction. Adv. Computers, 1, 43-91, Kalnay 2004.Phillips N., 1960a. On the problem of the initial data for the primitive equations, Tellus, 12, 121126.Phuong Nguyen Duc, 2013. Experiment on combinatorial Kalman filtering method for WRF model to forecast heavy rain in central region in Vietnam. 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Sci., 80, 629-638.Webster P.J., Magana V.O., Palmer T.N., Shukla J., Tomas R.A., Yanai M., Yasunari T., 1998. Monsoons: Processes, predictability, and teprospects for prediction, J. Geophys. Res., 103, 14451-14510.Wilks Daniel S., 1997. Statistical Methods in the Atmospheric Sciences. Ithaca New York., 59, 255.Whitaker J.S., Hamill T.M., 2002. Ensemble data assimilation without perturbed observations. Mon. Wea. Rev., 130, 1913.Wu G., Zhang Y., 1998. Tibetan plateau forcing and the timing of the monsoon onset over South Asia and the South China Sea. Mon.Wea.Rev., 126, 913-927.Zhang Z., Chan J.C.L., and Ding Y., 2004. Characteristics, evolution and mechanisms of the summer monsoon onset over Southeast Asia. J.Climatology, 24, 1461-1482.http://weather.uwyo.edu/upperair/sounding.html and http://tropic.ssec.wisc.edu/archive/
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Christopher, Pradeep, Bala Gughan, Poorna Devadoss et Naveen H. Krishnamurthy. « A Case of Cleft Hypoplastic Maxilla corrected by Single-stage Lefort 1 Osteotomy to improve Esthetics and Function ». Journal of Health Sciences & ; Research 6, no 1 (2015) : 25–27. http://dx.doi.org/10.5005/jp-journals-10042-1015.
Texte intégralRésumé :
ABSTRACT Among the congenital anomalies, cleft lip and palate take about 14% of the total population; among them, unilateral cleft lip and palate is predominant than bilateral. Cleft lip correction preceding the cleft palate is usually done within a gap of 3 years. Due to the wide median palatal cleft, a perfectly performed Langenbeck pushback closures can leave behind persistent oronasal fistulas during the healing process, due to which severe scarring of palatal mucosa takes place. Secondary alveolar grafting is a procedure performed irrespective of the age for persistent oronasal fistulas. Further closure of nasal and palatal fistula with intervening bone graft is always successful but can compromise the growth of maxilla resulting in hypoplasia. In one such case of a failed secondary alveolar grafting, a Lefort 1 advancement alone was done not only to improve the facial esthetics but also function. This paper discusses in detail the comprehensive surgical procedure performed. How to cite this article Christopher P, Gughan B, Devadoss P, Krishnamurthy NH. A Case of Cleft Hypoplastic Maxilla corrected by Single-stage Lefort 1 Osteotomy to improve Esthetics and Function. J Health Sci Res 2015;6(1):25-27.
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Babirad, A. M. « ATTITUDES TOWARDS DISEASE IN PATIENTS WITH CHRONIC PHASE OF ISCHEMIC STROKE BY THE RESULTS OF THE PERSONAL QUESTIONNAIRE OF THE BEKHTEREV INSTITUTE ». East European Journal of Parkinson`s Disease and Movement Disorders 6, no 3-4 (30 décembre 2020) : 19–26. http://dx.doi.org/10.33444/2414-0007.6.3-4.19-26.
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Every year, strokes are diagnosed in about 16 million people, of whom 5.7 million die and about the same number become disabled (Feigin V.L., Forouzanfar M.H., Krishnamurthi R., et al., 2014; Virani S.S., Alonso A., Benjamin E.J., et al., 2020; Kim J., Thayabaranathan T., Donnan G.A., et al. 2020). The objective of our research was to study the attitudes towards disease in patients with chronic phase of ischemic stroke. Material and methods. 100 consecutive patients with chronic phase of ischemic stroke and 17 patients with chronic cerebral ischemia were questioned in neurology in-patient department. The types of attitude towards disease were identified with the help of the Personal Questionnaire of the Bekhterev Institute. Results. We found that pathological types of attitude towards disease begin to form before the development of a stroke as a result of chronic cerebral ischemia. Among patients with chronic phase of ischemic stroke, pathological types of attitude towards disease prevailed significantly, and the harmonious type was rare (84.0% vs 16.0%, p < 0.001). The most frequently observed were neurasthenic (36.0%), harmonious (16.0%), anxious (16.0%), ergopathic (10.0%) and sensitive (8.0%) types of attitude towards disease. Our study has shown that any ischemic stroke, even in the case of complete recovery of the lost functions, can be associated with pathological types of attitude towards disease. Keywords: ischemic stroke, the Personal Questionnaire of the Bekhterev Institute, attitudes towards disease.
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Culbertson, Adam, Satyender Goel, Margaret Madden, Niloufar Safaeinili, Kathryn Jackson, Thomas Carton, Russ Waitman et al. « The Building Blocks of Inter-operability ». Applied Clinical Informatics 08, no 02 (avril 2017) : 322–36. http://dx.doi.org/10.4338/aci-2016-11-ra-0196.
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SummaryBackground: Patient matching is a key barrier to achieving interoperability. Patient demographic elements must be consistently collected over time and region to be valuable elements for patient matching.Objectives: We sought to determine what patient demographic attributes are collected at multiple institutions in the United States and see how their availability changes over time and across clinical sites.Methods: We compiled a list of 36 demographic elements that stakeholders previously identified as essential patient demographic attributes that should be collected for the purpose of linking patient records. We studied a convenience sample of 9 health care systems from geographically distinct sites around the country. We identified changes in the availability of individual patient demographic attributes over time and across clinical sites.Results: Several attributes were consistently available over the study period (2005–2014) including last name (99.96%), first name (99.95%), date of birth (98.82%), gender/sex (99.73%), postal code (94.71%), and full street address (94.65%). Other attributes changed significantly from 2005–2014: Social security number (SSN) availability declined from 83.3% to 50.44% (p<0.0001). Email address availability increased from 8.94% up to 54% availability (p<0.0001). Work phone number increased from 20.61% to 52.33% (p<0.0001).Conclusions: Overall, first name, last name, date of birth, gender/sex and address were widely collected across institutional sites and over time. Availability of emerging attributes such as email and phone numbers are increasing while SSN use is declining. Understanding the relative availability of patient attributes can inform strategies for optimal matching in healthcare.Citation: Culbertson A, Goel S, Madden MB, Jackson KL, Carton T, Waitman R, Liu M, Krishnamurthy A, Hall L, Cappella N, Visweswaran S, Safaeinili N, Becich MJ, Applegate R, Bernstam E, Rothman R, Matheny M, Lipori G, Bian J, Hogan W, Bell D, Martin A, Grannis S, Klann J, Sutphen R, O’Hara AB, Kho A. The building blocks of interoperability: A multisite analysis of patient demographic attributes available for matching. Appl Clin Inform 2017; 8: 322–336 https://doi.org/10.4338/ACI-2016-11-RA-0196
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Wang, Aicheng, Kejun Mao, Tao Li, Lizhao Guan, Yuhong Chen, Haiting Dai, Xian Wu et al. « Abstract 5609 : A WRN screening cascade to facilitate novel drug discovery ». Cancer Research 84, no 6_Supplement (22 mars 2024) : 5609. http://dx.doi.org/10.1158/1538-7445.am2024-5609.
Texte intégralRésumé :
Abstract Human RecQ deconjugating enzyme WRN is involved in DNA replication, DNA repair, recombination, transcription and telomere stabilization[1]. It plays a key role in nucleic acid metabolism as well. WRN defects lead to premature aging, type II diabetes, osteoporosis, atherosclerosis and cancer[2]. Hence it is of great interest of both pharmaceutical and academic field to develop the WRN inhibitors. Here we constructed an integrated experimental cascade, which contains both in vitro and in vivo assays, to conduct the high throughput hit-to-lead compound screen. WRN proteins of different length have been successfully purified and utilized to develop multiple biochemical assays such as unwinding assay and ATPase assay. We have also validated different cellular assays, including proliferation and immunofluorescence, to assess the cytotoxicity and the influence of downstream biomarkers of WRN inhibitors. A WRN knock-out cell line has been generated to better appreciate the inhibition mechanism. In addition, we have generated a WRN-HiBiT knock-in cell line to evaluate WRN degraders or target-compound interactions. Lastly, multiple CDX models utilizing different MSI or MSS cell lines have been validated to help determine the efficacy of WRN inhibitors thus shed light on the drug indications. Together our WRN screening cascade can provide comprehensive compound evaluation across in vitro and in vivo platforms, thus serve as an efficient screening platform for new drug discovery. [1] Kitano K. Structural mechanisms of human RecQ helicases WRN and BLM. Front Genet. 2014 Oct 29;5:366. [2]Hussain M, Krishnamurthy S, Patel J, Kim E, Baptiste BA, Croteau DL, Bohr VA. Skin Abnormalities in Disorders with DNA Repair Defects, Premature Aging, and Mitochondrial Dysfunction. J Invest Dermatol. 2021 Apr;141(4S):968-975. Citation Format: Aicheng Wang, Kejun Mao, Tao Li, Lizhao Guan, Yuhong Chen, Haiting Dai, Xian Wu, Jiabao Lv, Xu Wang, Cong Huang, Tiejun Bing. A WRN screening cascade to facilitate novel drug discovery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5609.
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Krishnamurthy, A., Y. Kisten, A. Circiumaru, K. Sakurabas, P. Jarvolli, J. J. Jimenez Andrade, P. Damberg et al. « OP0326 ACPA-INDUCED PAIN-BEHAVIOR, BONE LOSS AND TENDON INFLAMMATION IN MICE : A NOVEL MODEL FOR THE PRE-DISEASE PHASES OF ACPA-POSITIVE RHEUMATOID ARTHRITIS ». Annals of the Rheumatic Diseases 79, Suppl 1 (juin 2020) : 200.2–200. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5583.
Texte intégralRésumé :
Background:In rheumatoid arthritis (RA), anti-citrullinated protein antibodies (ACPAs) are associated with bone loss and pain. Recently, tenosynovitis has been suggested as a predicting factor for arthritis progression in individuals at-risk for RA.Objectives:We aimed to investigate if transfer of human ACPAs into mice could induce tenosynovitis and/or subclinical inflammation.Methods:Monoclonal ACPA (1325:04C03 and 1325:01B09) and control (1362:01E02) antibodies (mAbs) were generated from synovial plasma or memory B cells of RA patients. 2mg of combination of monoclonal ACPAs or control antibody were injected in BALB/c female mice (age 12-16 weeks) (n= 9). Pain-like behavior was monitored by measuring mechanical hypersensitivity using von Frey filaments every 3 days and estimation by up-down Dixon method. Bone morphometrics was analyzed by micro-CT. Using specially designed mobilization casts, dedicated mouse MRI coils, and gadolinium enhanced contrast medium, the hind limbs of these mice were scanned in a 9.4 T scanner and resulting T1-weighted images were evaluated for signs of soft tissue joint inflammation. The MRI images were scored for the presence of joint involvement and tendon inflammatory changes by 3 readers in a blinded manner.Figure 1.NAPA performed on healthy donor mo-DCs incubated with native, PAD2-citrullinated, and PAD4-citrullinated fibrinogen. Alpha, beta, and gamma chains of fibrinogen are shown separately. Each colored line represents a unique peptide. Nested peptides with a common core motif are shown in the same color. Grey bar denotes peptides with identical core motif between samples.Results:ACPAs (1325:04C03 and 1325:01B09) induced pain-like behavior (lasting for at least 4 weeks) and reduction of the trabecular and cortical bone thickness in the hind limbs as compared to control monoclonal antibodies (p<0.05). While no macroscopic or MRI signs of synovial inflammation were detected, MRI subclinical inflammation of the tendon sheaths was present in mice injected with ACPAs, but not in those injected with control mAb. Semi-quantitative scoring of the inflammatory tendon changes showed significant higher values in mice injected with ACPA (median of 1, range 0 to 2) than those injected with control mAb (median of 0, range 0 to 1).Conclusion:We show that ACPA induces pain-like behavior, bone loss and tendon sheath inflammation in mice, a model that mimics the preclinical state of ACPA positive RA.References:[1]Harre, U. et al. J Clin Invest (2012)[2]Krishnamurthy, A. et al. Ann Rheum Dis (2016, 2019), JI 2019[3]Wigerblad, G. et al. Ann Rheum Dis (2016, 2019)[4]KleyerA, Seminars in Arthritis and Rheumatism (2016)Disclosure of Interests:Akilan Krishnamurthy: None declared, Yogan Kisten: None declared, Alexandra Circiumaru: None declared, Koji Sakurabas: None declared, Patrik Jarvolli: None declared, Juan Jimenez Jimenez Andrade: None declared, Peter Damberg: None declared, Heidi Wähämaa: None declared, Vivianne Malmström Grant/research support from: VM has had research grants from Janssen Pharmaceutica, Lars Klareskog: None declared, Camilla Svensson: None declared, Bence Réthi: None declared, Anca Catrina: None declared
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Lati, R., R. Aly, H. Eizenberg et T. Lande. « First Report of the Parasitic Plant Phelipanche aegyptiaca Infecting Kenaf in Israel ». Plant Disease 97, no 5 (mai 2013) : 695. http://dx.doi.org/10.1094/pdis-10-12-1001-pdn.
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Kenaf (Hibiscus cannabinus L.; Malvaceae) is an annual fiber crop that has recently been introduced as a niche crop in Israel, and grown mainly at areas with high summer temperatures. It is advantageous in crop rotation in these areas since it can rapidly accumulate biomass under high temperatures when other crops (e.g., tomato, sunflower, corn, and sorghum) cannot be cultivated. Additionally, the fact that it can be irrigated with waste water makes it attractive under these climatic conditions. Broomrapes (Phelipanche and Orobanche spp.) are chlorophyll-lacking obligatory root-parasitic plants that parasitize the root system of many field crops and vegetables (1). Parasitism by P. aegyptiaca has economic impacts on various crops belonging to several botanical families (e.g., Solanaceae, Apiaceae, Fabaceae, and Asteraceae). This parasitic weed is common in most agricultural areas in Israel including the coastal plain, Yisre'el Valley, the Jordan Valley, and the Negev Desert. High infection levels by P. aegyptiaca have result in a severe yield losses and quality reduction in these crops. Parasitism of P. aegyptiaca on kenaf was observed in September 2012 in a field located in Bet-Shean Valley (Latitude 32° 30' N; Longitude 35° 30' E; 105 m), with an average density of 0.7 plant/m2, in a total area of 0.3 ha. This crop was planted on May 2012 in plots that were previously affected. Infection did not lead to visible symptoms or damage to kenaf, but allowed seed production by the parasite. In order to verify that kenaf was a host of P. aegyptiaca, 10 samples of kenaf plants infected with P. aegyptiaca were taken to the lab and the root systems of the plant and the parasite were carefully washed. Cross-sections of the connection between kenaf and the parasite were taken and inspected for xylem connections under a compound microscope (BX61, Olympus) equipped with high-resolution digital camera (DP-70, Olympus), under 40× magnification. A clear xylem connection between the weed's tubercles and kenaf roots was observed, confirming the development of functional Phelipanche haustoria. To our knowledge, this is the first report of kenaf as a host for P. aegyptiaca. Kenaf has been reported to induce the germination of O. cernua in India (3). Cotton, another member of the Malvaceae, has also been reported to stimulate seed germination of O. minor (4) and P. aegyptiaca (2). However, to the best of our knowledge, this finding reports the first occurrence of a Malvaceae crop as a host for P. aegyptiaca. References: (1) H. Eizenberg et al. Weed Sci. 55:152, 2007. (2) M. Ghotbi et al. Int. J. Agri. Sci. 2:62, 2012. (3) G. V. G. Krishnamurthy et al. Indian J. Weed Sci. 9:95, 1977. (4) Y. Ma et al. Agron. J. 104:569, 2012.
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Siqueira, Rebeca Talita de Souza, Débora Rayssa Siqueira Silva, Hellen Alves de Carvalho, Pedro Lucas de Araújo Rocha, Brena Paixão de Araújo Souza, Marília Soares Santana, Jéssika Cristina de Lima, Pauliana Valeria Machado Galvão, Daniele Padilha Lapa et Patrícia de Moraes Soares Santana. « Análise do perfil clínico e sociodemográfico dos pacientes pediátricos diagnosticados com glomerulonefrite difusa aguda em hospital no Sertão de Pernambuco, Brasil ». ARCHIVES OF HEALTH INVESTIGATION 9, no 5 (6 octobre 2020) : 420–25. http://dx.doi.org/10.21270/archi.v9i5.5048.
Texte intégralRésumé :
Introdução: A glomerulonefrite difusa aguda é uma glomerulopatia decorrente do dano inflamatório dos componentes glomerulares, comumente encontrada em pacientes pediátricos, com padrão e prevalência variáveis de acordo com idade, sexo, fatores socioeconômicos e geográficos (principalmente nas glomerulonefrites infecciosas ou pós-infecciosas), sendo a causa mais comum de acometimento renal após os seis anos de idade. Porém, faltam dados mundiais precisos sobre a prevalência da síndrome. Objetivo: Traçar o perfil sociodemográfico e clínico dos pacientes pediátricos diagnosticados com esta glomerulonefrite no Hospital Regional Professor Agamenon Magalhães, localizado no município de Serra Talhada, Pernambuco. Material e método: Trata-se de um estudo retrospectivo e descritivo de corte transversal. A coleta de dados foi realizada entre agosto de 2018 a junho de 2019, através da análise dos prontuários dos pacientes pediátricos que foram diagnosticados com glomerulonefrite difusa aguda. Resultados: 29 prontuários foram analisados, correspondendo aos anos 2015 a 2018, sendo 51,72% do sexo masculino, residente em Serra Talhada e em zona rural, com idade média 7,7 anos, todos de etnia parda. Em admissão para atendimento hospitalar 75,86% da amostra apresentou estado geral regular, e apenas 3,45% grave. 34,48% da população estudada apresentou oligúria, 89,66% edema generalizado, 58,62% hipertensão arterial durante admissão, 27,59% cefaleia e 55,17% febre. Conclusão: Os resultados obtidos através da pesquisa destacam a importância de traçar o perfil para guiar os profissionais do serviço na assistência aos pacientes pediátricos acometidos pela patologia abordada.
Descritores: Glomerulonefrite; Glomérulos Renais; Pediatria.
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Bertola EA, Simonetti GD, Del Giorno R, Giannini O, Fossali EF, Meoli M, et al. Extrarenal Immune-mediated disorders linked with acute poststreptococcal glomerulonephritis: a systematic review. Clinic Rev Allerg Immunol. 2019;57(2): 294-302.
Sethi S, Fervenza FC. Standardized classification and reporting of glomerulonephritis. Nephrol Dial Transplant. 2018;34(2):193-99.
Kılıc BD, Akbalık MK, Buyukcelik M, Balat A. Pediatric post-streptococcal glomerulonephritis: Clinical and laboratory data. Pediatr Int. 2018; 60(7):645‐50.
Ali el-TM, Babikir AM, El-Assad S, Abdelrahim MB. Prognosis of acute post-streptococcal glomerulonephritis in Sudanese children. Arab J Nephrol Transplant. 2014;7(2):103‐7.
Gunasekaran K, Krishnamurthy S, Mahadevan S, Harish BN, Kumar AP. Clinical characteristics and outcome of post-infectious glomerulonephritis in children in Southern India: a prospective study. Indian J Pediatr. 2015;82(10):896‐903.
Maia MLA, Vale MLD, Hatanaka E. Recomendações: Atualização de Condutas em Pediatria. Departamento de Nefrologia. Síndrome nefrítica. Departamentos Científicos SPSP, n. 88, p.10-14, 2019.
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Velpandian, Muthuraja, et Praveen Meduri. « (Digital Presentation) Interface Engineering of Transition Metal-Selenide Heterostructures for Application in Electrochemical Water-Splitting ». ECS Meeting Abstracts MA2022-01, no 41 (7 juillet 2022) : 2490. http://dx.doi.org/10.1149/ma2022-01412490mtgabs.
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Transition metal selenides (TMS) have sparked great interest in energy storage and catalysis because they are direct bandgap materials, have a highly layered structure, high redox activity, abundant active sites at the edges, short diffusion paths, and large surface area1. However, low electrical conductivity and structural instability result in long-term performance degradation. The development of high-performance water electrolyzers and metal-air batteries requires the design and construction of efficient TMS electrocatalysts. In order to boost electrochemical activity, increasing emphasis has been devoted to interface engineering of TMS heterostructures through manipulation of composition, adjustment of crystal facets, and heteroatomic doping2. Interface engineering helps in optimizing reaction intermediates, modulating charge carrier characteristics, and preventing the aggregation of active components. Herein, we designed and studied the interface between hydrothermally synthesized tin selenide (SnSe2) and tungsten selenide (WSe2). The intimate electronic interaction between the bimetallic selenides leads to a rich interface boundary that reduces the surface energy and creates a larger number of active sites involved in both the hydrogen evolution and oxygen evolution reactions3. These heterostructures exhibited a low overpotential of 180 mV at 10 mA cm-2 and good stability of up to 12 hours for the hydrogen evolution reaction, and a low overpotential of 250 mV at 10 mA cm-2 and stability up to 12 hours for the oxygen evolution reaction. This study gives a better insight into the design of TMS heterostructures using interface engineering for high electrocatalytic activity. References: (1) Gbadamasi, S.; Mohiuddin, M.; Krishnamurthi, V.; Verma, R.; Khan, M. W.; Pathak, S.; Kalantar-Zadeh, K.; Mahmood, N. Interface Chemistry of Two-Dimensional Heterostructures – Fundamentals to Applications. Chem. Soc. Rev. 2021, 50 (7), 4684–4729. https://doi.org/10.1039/D0CS01070G. (2) Zhao, R.; Li, Q.; Jiang, X.; Huang, S.; Fu, G.; Lee, J.-M. Interface Engineering in Transition Metal-Based Heterostructures for Oxygen Electrocatalysis. Mater. Chem. Front. 2021, 5 (3), 1033–1059. https://doi.org/10.1039/D0QM00729C. (3) Chen, P.; Tong, Y.; Wu, C.; Xie, Y. Surface/Interfacial Engineering of Inorganic Low-Dimensional Electrode Materials for Electrocatalysis. Acc. Chem. Res. 2018, 51 (11), 2857–2866. https://doi.org/10.1021/acs.accounts.8b00266.
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Krishnamurthy, Sathyashree, et Pooja Mehta. « Equation between Incisor Inclination Correction and Anteroposterior Movement of Point A to determine the Actual Magnitude of Maxillomandibular Difference ». World Journal of Dentistry 8, no 4 (2017) : 300–303. http://dx.doi.org/10.5005/jp-journals-10015-1454.
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ABSTRACT Aim To determine the actual position of point A by performing incisor inclination correction in class II division 2 and class III. Also, to determine the relation between the degree of incisor inclination correction and anteroposterior movement of point A by studying pre- and postalignment lateral cephalograms. Materials and methods The pre- and postalignment lateral cephalograms of 33 class II division 2 and 33 class III patients treated orthodontically were traced manually and analyzed. The linear anteroposterior measurements of point A and center of rotation in relation to the vertical reference plane and angular measurements of upper incisor to maxillary plane were calculated. Results In class II division 2 category, the mean change in inclination from pre- to postalignment was 15.27°, mean change in position of center of rotation was -1.29 mm, and mean change in position of point A from pre- to postalignment was -2.67 mm. In class III category, the mean change in inclination from pre- to postalignment was -5.85°, mean change in position of center of rotation from pre- to postalignment was 1.94 mm, and mean change in position of point A from pre- to postalignment was 1.77 mm. Conclusion The results of the study confirmed that for every 10° proclination of the upper incisor in class II division 2, point A moves 0.3 mm palatally and for every 10° retroclination of the upper incisor in class III, point A moves 0.73 mm labially. Clinical significance In the clinical scenario of severely retroclined/proclined incisors, point A cannot depict the actual anterior limit of maxilla. Hence, when we use SNA to determine the anteroposterior position of maxilla and ANB to determine maxillomandibular difference, invariably we get altered values. Therefore, it is necessary to find an equation between the degree of incisor inclination correction and anteroposterior movement of point A. How to cite this article Shivamurthy PG, Krishnamurthy S, Mehta P, Mathew S. Equation between Incisor Inclination Correction and Anteroposterior Movement of Point A to determine the Actual Magnitude of Maxillomandibular Difference. World J Dent 2017;8(4):300-303.
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Keiding, Niels, et Jørgen Hilden. « Statistics an interactive text for the health and life sciences. Goteti Bala Krishnamurty, Patricia Kasovia-Schmitt and David J. Ostroff, Joness and Bartlett Publishers, Boston, 1995. No. of pages : xxiv + 709. Price £14.95. ISBN : 0-86720-898-6 ». Statistics in Medicine 14, no 23 (15 décembre 1995) : 2621–22. http://dx.doi.org/10.1002/sim.4780142311.
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Bavisi, Karishma, Sebastian Wurster, Nathaniel Albert, Sattva Neelapu, Dimitrios P. Kontoyiannis et Pappanaicken Kumaresan. « 768 Re-directed T cell therapy to control invasive aspergillosis ». Journal for ImmunoTherapy of Cancer 8, Suppl 3 (novembre 2020) : A816. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0768.
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BackgroundOpportunistic invasive fungal infections (IFI) are a major threat to immunocompromised populations such as patients with acute myeloid leukemia (AML) and allogenic hematopoietic stem cell transplant (HSCT) recipients(1,2). Specifically, Aspergillus fumigatus (AF) is responsible for high morbidity and mortality in cancer patients. As antifungal therapy has limited efficacy in immunocompromised patients, we sought to develop fungus-specific chimeric antigen receptor (CAR) T cells as a novel immune augmentation strategy to treat IFIs including invasive aspergillosis. To target fungal pathogens, we fused the pattern-recognition receptor Dectin-1 to activate T cells via chimeric CD28 and CD3-ζ domains upon binding to β-1,3-glucan carbohydrates in the fungal cell wall(3). The generated Dectin-1 CAR+ T cells showed high specificity for β-1,3-gucan and inhibited the growth and branching of AF germlings in an in-vitro co-culture assay. However, we found poor efficacy of Dectin-1 CAR+ T cells against mature AF hyphae, likely due to changes in the fungal cell wall that hamper T-cellular binding to β-1,3-glucan carbohydrates. To overcome this limitation, we have recently developed an AF-specific CAR (AF-CAR) based on a monoclonal antibody which recognizes a surface epitope of mature AF hyphae.MethodsLentiviral vectors were used to generate AF-CAR expressing T cells from human peripheral blood mononuclear cells. Heat killed AF-293 hyphae was used for co-culture studies with No DNA T cells, and AF-CAR expressing T cells. Cell clusters, binding with AF hyphae were noticed in AF-CAR incubated wells whereas no such cell cluster were observed in NoDNA T cells incubated wells.ResultsWhen co-incubated with AF hyphae, AF-CAR+ T cells efficiently targeted mature hyphae and formed lytic synapses with hyphal filaments. The released cytolytic granules damage hyphae and controls branch node formation. Furthermore, exposure to AF hyphae stimulated significant upregulation of activation markers CD69 and CD154 on AF-CAR+ T cells. The activated CAR T cell secretes proinflammatory cytokines which can boost innate immune system to fight against IFI.ConclusionsIn summary, these results indicate that we have successfully generated a novel anti-Aspergillus CAR construct with good in-vitro targeting efficacy against mature AF hyphae. After thorough evaluation of fungicidal activity, cytokine response patterns, and release of cytotoxic mediators, we plan to embark on preclinical tolerability and efficacy studies in a murine model of invasive pulmonary aspergillosis. Thus, we report the production of Aspergillus specific CAR T cells to provide long term protection to immunocompromised patients, such as AML patients and HSCT recipients, from invasive Aspergillus infections.AcknowledgementsThis study was supported by NIAID-R33 AI127381.Ethics ApprovalThis study was approved by IBC committee, University of Texas MD Anderson Cancer Center, Houston, Texas, 77030.ReferencesPappas PG, Alexander BD, Andes DR, Hadley S, Kauffman CA, Freifeld A, Anaissie EJ, Brumble LM, Herwaldt L, Ito J, Kontoyiannis DP, Lyon GM, Marr KA, Morrison VA, Park BJ, Patterson TF, Perl TM, Oster RA, Schuster MG, Walker R, Walsh TJ, Wannemuehler KA, Chiller TM. Invasive fungal infections among organ transplant recipients: results of the transplant-associated infection surveillance network (TRANSNET). Clin Infect Dis 2010;50(8):1101–11.Bhatt VR, Viola GM, Ferrajoli A. Invasive fungal infections in acute leukemia. Ther Adv Hematol 2011;2(4):231–47.Kumaresan PR, Manuri PR, Albert ND, Maiti S, Singh H, Mi T, Roszik J, Rabinovich B, Olivares S, Krishnamurthy J, Zhang L, Najjar AM, Huls MH, Lee DA, Champlin RE, Kontoyiannis DP, Cooper LJ, Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection. Proc Natl Acad Sci U S A 2014;111(29):10660–5.
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Velpandian, Muthuraja, et Praveen Meduri. « (Digital Presentation) Electrospun Bimetallic Cu/Zn Selenide @ Carbon Nanofiber Electrocatalysts for Oxygen Evolution and Oxygen Reduction ». ECS Meeting Abstracts MA2023-01, no 36 (28 août 2023) : 2122. http://dx.doi.org/10.1149/ma2023-01362122mtgabs.
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Electrochemical water splitting and fuel cells are intriguing ways to achieve a potentially sustainable and clean energy1. A greater focus on these energy technologies necessitates the design and development of highly active, cost-effective electrocatalysts that can substitute state of the art noble metal based materials2. In this context, metal selenide-based materials are important owing to their superior stability and electrical conductivity3. Their high specific surface area and abundant active sites on the surfaces make them strong candidates for use as electrocatalysts. Herein, heterostructured copper selenide and zinc selenide encased in carbon nanofibers (CZSe@C-450) synthesized using electrospinning and selenization techniques are used as bifunctional electrocatalysts. The novel architecture and tunable confinement of bimetallic selenides with the carbon matrix results in improved electrochemical performance in both oxygen evolution (OER) and oxygen reduction reactions (ORR)4. CZSe@C-450 exhibits a low overpotential of 260 mV at 10 mA cm−2 for oxygen evolution reaction and exhibits a half-wave potential (E1/2) of 0.88 V for oxygen reduction reaction. Further, the creation of a heterogeneous phase boundary between copper selenide and zinc selenide in the CZSe@C-450 enhances the built-in potential, local atomic disorder, and mismatch in the lattice that leads to lowering the surface energy. This gives rise to creation of catalytically active edge sites and phase boundaries, which contribute to the enhanced performance and good stability in both OER and ORR5,6. References: (1) Gielen, D.; Taibi, E.; Miranda, R. Hydrogen: A Renewable Energy Perspective. Abu Dhabi: International Renewable Energy Agency 2019. (2) Han, L.; Dong, S.; Wang, E. Transition‐metal (Co, Ni, and Fe)‐based Electrocatalysts for the Water Oxidation Reaction. Advanced materials 2016, 28 (42), 9266–9291. (3) Feng, W.; Pang, W.; Xu, Y.; Guo, A.; Gao, X.; Qiu, X.; Chen, W. Transition Metal Selenides for Electrocatalytic Hydrogen Evolution Reaction. ChemElectroChem 2020, 7 (1), 31–54. https://doi.org/10.1002/celc.201901623. (4) Velpandian, M.; Ummethala, G.; Malladi, S. K.; Meduri, P. Heterogeneous Interface Induced Electrocatalytic Efficiency Boosting of Bimetallic Cu/Zn Selenides for Stable Water Oxidation and Oxygen Reduction Reactions. Catalysis Science & Technology 2022. (5) Gbadamasi, S.; Mohiuddin, M.; Krishnamurthi, V.; Verma, R.; Khan, M. W.; Pathak, S.; Kalantar-Zadeh, K.; Mahmood, N. Interface Chemistry of Two-Dimensional Heterostructures – Fundamentals to Applications. Chem. Soc. Rev. 2021, 50 (7), 4684–4729. https://doi.org/10.1039/D0CS01070G. (6) Zhao, R.; Li, Q.; Jiang, X.; Huang, S.; Fu, G.; Lee, J.-M. Interface Engineering in Transition Metal-Based Heterostructures for Oxygen Electrocatalysis. Mater. Chem. Front. 2021, 5 (3), 1033–1059. https://doi.org/10.1039/D0QM00729C.
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Fung, Russell K., Madeline Fasen, Firas Warda, Patrick Natter, Stacey Nedrud, Rui Fernandes, Ahmad Alkhasawneh et Gunjan Yogendra Gandhi. « Clavicular Metastasis as an Initial Presentation of Papillary Thyroid Cancer ». Journal of the Endocrine Society 5, Supplement_1 (1 mai 2021) : A885—A886. http://dx.doi.org/10.1210/jendso/bvab048.1808.
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Abstract Background: Papillary thyroid cancer (PTC) metastases to the clavicular bone is rare. While the lung is considered the most common site of metastases from thyroid malignancy, osseous metastases, if seen, are usually observed at sites such as humerus, pelvis, radius, and scapula. Clinical Case: A 44-year-old man presented with an enlarging right neck mass for six months after light trauma to that area. Other than mild pain in the described area, the patient reported 20 lbs of weight loss. Initial x-ray revealed a large soft tissue density mass that extended to the midline of the right proximal clavicle. Soft-tissue neck ultrasound noted a 5.4 x 3.6 cm mass extending from the thyroid with findings of increased vascularity and calcification. CT scan of the neck depicted the extension of the mass into the adjacent sternoclavicular junction with osteolysis of the middle third of the clavicle as well as the superior aspect of the sternal body. A fine needle aspiration of the mass revealed thyroid neoplasm with follicular features and positive immunostaining consistent with thyroid carcinoma. Chest CT showed invasion into the right proximal clavicle, tracheal deviation and extension into the mediastinum. The patient underwent a composite resection of the tumor, including a segmental osteotomy of approximately two-thirds of the medial clavicle. Post surgically the patient’s serum calcium was low at 7.9 mg/dL with a concurrently low PTH of 9 pg/mL and a low 25-hydroxyvitamin D of 16.8 ng/mL. Thyroglobulin was markedly high at 15655.0 ng/mL (confirmed on dilution), and thyroglobulin antibody < 1.0 IU/mL. Pathology report confirmed PTC with extra-thyroidal extension and involvement of clavicle (staged pT4a pN0), however margins and lymph nodes were negative for carcinoma with further genomic findings showing positive KRAS mutation. The patient’s post-operative course was complicated by a large expanding left neck hematoma after a fall; he was immediately readmitted with the hematoma subsequently safely evacuated. Levothyroxine has been held at this time with plans for radioactive iodine treatment eight weeks after surgery. Conclusion: Bone metastases from differentiated thyroid cancer is rare, especially clavicular metastasis arising from PTC. Bone scintigraphy, x-ray and fine needle biopsy are some of the widely utilized methods employed in the evaluation of bone metastasis in the setting of thyroid malignancy. The prospect of recovery is generally favorable in cases of bone metastases, however various factors can affect prognosis and long-term outcomes. Reference: Krishnamurthy A. Clavicle metastasis from carcinoma thyroid- an atypical skeletal event and a management dilemma. Indian J Surg Oncol. 2015;6(3):267-270. doi:10.1007/s13193-015-0387-y
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Deissler, Niklas Henrik, Jon Bjarke Valbaek Mygind, Katja Li, Valerie Anne Niemann, Peter Benedek, Valentin Vinci, Jakub Drnec, Thomas F. Jaramillo, Jakob Kibsgaard et Ib Chorkendorff. « Investigating Solid Electrolyte Interphase Layer Dynamics in the Electrochemical Li-Mediated Ammonia Synthesis ». ECS Meeting Abstracts MA2023-02, no 55 (22 décembre 2023) : 2712. http://dx.doi.org/10.1149/ma2023-02552712mtgabs.
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Due to its important role in the production of fertilizers ammonia is one of the most produced chemicals worldwide. In recent years there has been increasing interest in the electrochemical lithium mediated nitrogen reduction reaction (LMNRR), as a possible alternative to the Haber-Bosch process. The LMNRR is advantageous as it can be carried out under ambient temperatures and pressures [1]. The LMNRR process involves electrochemical plating of metallic Li from an organic electrolyte. This plated Li reacts with elemental nitrogen forming an intermediate nitride species, which is subsequently protonated to form ammonia. To ensure high selectivity towards ammonia production the competing hydrogen evolution reaction has to be limited [2]. The solid electrolyte interphase (SEI), formed from electrolyte decomposition at the working electrode plays a crucial role in this as it influences mass transport to the electrode [3]. Studies using neutron reflectometry with one-minute time resolution investigated the initial stages of SEI formation in LiClO4 containing electrolytes [4]. Recent investigations show improved performance using LiBF4 containing electrolytes [5]. In this study formation and dynamics of the SEI layer derived from LiClO4 and LiBF4 containing electrolytes were examined in operando using grazing incidence wide-angle X-ray scattering (GI WAXS) in a synchrotron setup. The use of GI WAXS provides a time resolution in the seconds range, enabling the identification of transient species and fluctuations of deposits on the electrode surface. Different SEI species and their dynamics have been observed and correlated with electrolyte composition and faradaic efficiency towards ammonia. Figure 1a) shows the dynamic behavior of diffraction features attributed to Li and LiF in an experiment using LiBF4 as electrolyte salt. In Figure 1b) the development of the corresponding peak intensities is shown and correlated with the start and end of chronopotentiometry (CP), used to study the cell. LiF was formed from the decomposition of LiBF4 and accumulated on the working electrode, showing that LiF is a significant component of the SEI in fluoride-containing electrolytes. Furthermore, metallic Li was found to be more stable when LiBF4 was utilized as electrolyte salt, in contrast to LiClO4. This finding suggests that the SEI derived from LiF has different mass transport characteristics and is more robust than that derived from LiClO4. This may explain the previously reported superior performance of electrolytes containing LiBF4 [5]. References [1] S. Z. Andersen et al., “A rigorous electrochemical ammonia synthesis protocol with quantitative isotope measurements,” Nature, vol. 570, no. 7762, pp. 504–508, Jun. 2019, doi: 10.1038/s41586-019-1260-x. [2] S. Z. Andersen et al., “Increasing stability, efficiency, and fundamental understanding of lithium-mediated electrochemical nitrogen reduction,” Energy Environ. Sci., vol. 13, no. 11, pp. 4291–4300, Nov. 2020, doi: 10.1039/d0ee02246b. [3] N. Lazouski, K. J. Steinberg, M. L. Gala, D. Krishnamurthy, V. Viswanathan, and K. Manthiram, “Proton Donors Induce a Differential Transport Effect for Selectivity toward Ammonia in Lithium-Mediated Nitrogen Reduction,” ACS Catal., pp. 5197–5208, Apr. 2022, doi: 10.1021/acscatal.2c00389. [4] S. J. Blair et al., “Lithium-Mediated Electrochemical Nitrogen Reduction: Tracking Electrode–Electrolyte Interfaces via Time-Resolved Neutron Reflectometry,” ACS Energy Lett., vol. 7, no. 6, pp. 1939–1946, Jun. 2022, doi: 10.1021/acsenergylett.1c02833. [5] K. Li et al., “Increasing Current Density of Li-Mediated Ammonia Synthesis with High Surface Area Copper Electrodes,” ACS Energy Lett., vol. 7, no. 1, pp. 36–41, Jan. 2022, doi: 10.1021/acsenergylett.1c02104. Figure 1
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Bao, Leo, Thomas DeSilvio, Benjamin N. Parker, Mohsen Hariri, Prathyush Chirra, Murad Labbad, Stephen Tang et al. « Abstract 2582 : Intra- and peri-tumoral radiomic features are predictive of pathologic response to multiple neoadjuvant therapy regimen in rectal cancers via pre-treatment MRI ». Cancer Research 84, no 6_Supplement (22 mars 2024) : 2582. http://dx.doi.org/10.1158/1538-7445.am2024-2582.
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Abstract Introduction: Rectal cancers undergo neoadjuvant chemoradiation prior to resection, with increasing evidence that neoadjuvant chemotherapy or immunotherapy can boost clinical or pathologic response rates. However, baseline clinical tumor staging and carcinoembryonic antigen levels are limited for identifying which patients will most benefit from a multimodal neoadjuvant regimen, and which will not. We evaluated whether radiomics (computational features from radiographic images) from pretreatment MRI could identify which rectal cancer patients will achieve clinical or pathologic response to different neoadjuvant treatment regimens. Methods: MRI scans were retrospectively obtained from 3 different institutions for rectal cancer patients who had either undergone neoadjuvant chemoradiation or an experimental immunotherapy + chemoradiation. After pre-processing all MRI scans, tumor was manually delineated with an automated annotation of a 10 mm peritumor region. 916 radiomic features were extracted from two planes of acquisition (axial, coronal) and two ROIs (tumor, peritumor). 5 top-ranked radiomic features were identified from each region and plane via multi-stage mutual information feature selection to train a linear discriminant machine classifier to assign a predicted likelihood of achieving complete response to each patient. Model performance was validated via ROC analysis against response groups defined via (i) tumor regression grade indicating no tumor present on surgical pathology, and (ii) 1-year clinical complete response for patients who underwent non-operative management. Clinical variables (CEA, clinical stage) were statistically compared between response groups. Results: Training cohort comprised 64 patients who underwent chemoradiation alone (2 institutions, median age 61 yrs, M:F:MtF = 36:27:1). Validation cohort included 37 patients who underwent experimental TGFß inhibitor therapy prior to chemotherapy + chemoradiation (1 institution, median age 51 yrs, M:F = 25:12). Area under the ROC curve for multi-plane tumor+peritumor radiomic features (0.765 ± 0.054) was significantly higher for distinguishing complete response vs non/partial response compared to tumor (AUC = 0.635 ± 0.057, p < 0.0001) or peritumor (AUC = 0.612 ± 0.064, p < 0.0001). In holdout validation, performance was maintained with AUCs of 0.742 (tumor) 0.596 (peritumor), and 0.700 (all), respectively. Baseline CEA levels (p=0.3385) and cT stage (p=0.3386) were found to lack statistical significance as a predictor of response. Conclusion: Radiomic features from tumor and peritumor regions on pre-treatment MRI scans in rectal cancer patients may enable robust and accurate identification of pathologic or near-complete response after multiple neoadjuvant treatment regimen, while outperforming baseline clinical variables. Citation Format: Leo Bao, Thomas DeSilvio, Benjamin N. Parker, Mohsen Hariri, Prathyush Chirra, Murad Labbad, Stephen Tang, Gregory M. O'Connor, Emily Steinhagen, Jennifer L. Miller-Ocuin, Amit Gupta, Eric L. Marderstein, Aaron Carroll, Marka Crittenden, Michael J. Gough, Smitha Krishnamurthi, Kristina H. Young, Satish E. Viswanath. Intra- and peri-tumoral radiomic features are predictive of pathologic response to multiple neoadjuvant therapy regimen in rectal cancers via pre-treatment MRI [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2582.
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Pène, Véronique, Qisheng Li, Catherine Sodroski, Ching-Sheng Hsu et T. Jake Liang. « Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection ». Journal of Virology 89, no 10 (4 mars 2015) : 5462–77. http://dx.doi.org/10.1128/jvi.03197-14.
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ABSTRACTThe ubiquitous ATP-dependent RNA helicase DDX3X is involved in many cellular functions, including innate immunity, and is a pivotal host factor for hepatitis C virus (HCV) infection. Recently, we showed that DDX3X specifically recognizes the HCV 3′ untranslated region (UTR), leading to the activation of IKK-α and a cascade of lipogenic signaling to facilitate lipid droplet biogenesis and viral assembly (Q. Li, V. Pene, S. Krishnamurthy, H. Cha, and T. J. Liang, Nat Med19:722–729, 2013,http://dx.doi.org/10.1038/nm.3190). The interaction of DDX3X with HCV core protein seems to be dispensable for its proviral role. In this study, through systematic imaging and biochemical and virologic approaches, we identified a dynamic association between DDX3X and various cellular compartments and viral elements mediating multiple functions of DDX3X in productive HCV infection. Upon HCV infection, the HCV 3′UTR interacts with DDX3X and IKK-α, which redistribute to speckle-like cytoplasmic structures shown to be stress granules (SGs). As viral proteins accumulate in infected cells, DDX3X granules together with SG-associated proteins redistribute and colocalize with HCV core protein around lipid droplets (LDs). IKK-α, however, does not relocate to the LD but translocates to the nucleus. In HCV-infected cells, various HCV nonstructural proteins also interact or colocalize with DDX3X in close proximity to SGs and LDs, consistent with the tight juxtaposition of the replication complex and the assembly site at the surface of LDs. Short interfering RNA (siRNA)-mediated silencing of DDX3X and multiple SG components markedly inhibits HCV infection. Our data suggest that DDX3X initiates a multifaceted cellular program involving dynamic associations with HCV RNA and proteins, IKK-α, SG, and LD surfaces for its crucial role in the HCV life cycle.IMPORTANCEDDX3X is a proviral host factor for HCV infection. Recently, we showed that DDX3X binds to the HCV 3′UTR, activating IKK-α and cellular lipogenesis to facilitate viral assembly (Q. Li et al., Nat Med19:722–729, 2013,http://dx.doi.org/10.1038/nm.3190). Here, we report associations of DDX3X with various cellular compartments and viral elements that mediate its multiple functions in the HCV life cycle. Upon infection, the HCV 3′UTR redistributes DDX3X and IKK-α to speckle-like cytoplasmic structures shown to be SGs. Subsequently, interactions between DDX3X, SG, and HCV proteins facilitate the translocation of DDX3X-SG complexes to the LD surface. HCV nonstructural proteins are shown to colocalize with DDX3X in close proximity to SGs and LDs, consistent with the tight juxtaposition of the HCV replication complex and assembly site at the LD surface. Our data demonstrate that DDX3X initiates a multifaceted cellular program involving dynamic associations with HCV elements, IKK-α, SGs, and LDs for its critical role in HCV infection.
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Shimizu, Yugo, Atsushi Fukazawa, Naoki Shida et Mahito Atobe. « (Digital Presentation) Diastereoselective Electrocatalytic Hydrogenation of Mono-Substituted Cyclohexanones in a Proton Exchange Membrane Reactor ». ECS Meeting Abstracts MA2022-01, no 42 (7 juillet 2022) : 1841. http://dx.doi.org/10.1149/ma2022-01421841mtgabs.
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Cyclic alcohols are important building blocks of pharmaceuticals, perfumes, and liquid crystals. For instance, 4-tert-butylcyclohexyl acetate, which is derived from 4-tert-butylcyclohexanol (1), is a commercialized synthetic fragrance that is used more than 106 kg per year. The fragrance of its cis-isomer is more potent odorant than that of its trans-isomer, and hence, cis-4-tert-butylcyclohexyl acetate is obtained by acetylation of the corresponding alcohol, i.e., cis-1. On the other hand, cis-1 is generally obtained by the reduction of 4-tert-butylcyclohexanone (2). The use of sterically hindered L-selectride as a reductant gave 1 with 93% cis-isomer selectivity [1]. The stereoselective hydrogenation of ketone 2 to 1 with ruthenium-aminophosphine complexes using hydrogen gas and base also afford 96% cis-isomer [2]. Although high cis-selectivity is achieved by these methods, the use of hazardous reagents and their separation problems in the workup humper the large-scale application. Replacement of such homogeneous reductions (hydrogenations) by heterogeneous catalytic systems brings several economic and technical advantages. A major advantage of using heterogeneous catalysts is that the catalyst can be recovered from the reaction mixture by simple filtration. Therefore, the highly diastereoselective reduction (hydrogenation) of cyclic ketones using heterogeneous catalysts is a meaningful and challenging topic for sustainable chemistry. Here, we demonstrate the electrocatalytic hydrogenation of mono-substituted cyclohexanones in a proton exchange membrane (PEM) reactor (Figure 1a). We have investigated the effect of catalyst materials and current density on the current efficiency and cis-selectivity of the desired products. As a result, it was found that the use of the PEM reactor with Rh catalyst gave 1 with high cis-selectivity (94%) and high current efficiency (93%), as shown in Figures 1b and c. In addition, it was also confirmed that the present system was capable of continuous operation for several tens of hours and gram-scale electrolysis without loss of diastereoselectivity. Unlike conventional hydrogenation methods that are carried out under high temperature and high pressure, the PEM reactor can carry out the desired hydrogenation reaction under ambient temperature and pressure, which also suggests a significant improvement in energy efficiency. Furthermore, the reaction products are easily separated and the catalyst is highly recyclable. Thus, the hydrogenation using PEM reactors can realize energy-saving and clean organic reaction processes. The authors gratefully acknowledged support by JST CREST Grant No. JPMJCR18R1, Japan. References [1] Brown, H.C.; Krishnamurthy, S.J. Lithium Tri-sec-butylborohydride. New Reagent for the Reduction of Cyclic and Bicyclic Ketones with Super Stereoselectivity. Remarkably Simple and Practical Procedure for the Conversion of Ketones to Alcohols in Exceptionally High Stereochemical Purity. J. Am. Chem. Soc. 1972, 94, 7159–7161. [2] Abdur-Rashid, K.; Chen, X.; Guo, R.; Jia, W. Method for the preparation of cis-4-tert-butylcyclohexanol. U.S. Patent 2010/0204524, A1, 2010. Figure 1
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Krishnamurthy, Deepak, et Ganesh Subramanian. « Heat or mass transport from drops in shearing flows. Part 2. Inertial effects on transport ». Journal of Fluid Mechanics 850 (6 juillet 2018) : 484–524. http://dx.doi.org/10.1017/jfm.2018.481.
Texte intégralRésumé :
We analyse the singular effects of weak inertia on the heat (or equivalently mass) transport problem from drops in linear shearing flows. For small spherical drops embedded in hyperbolic planar linear flows, which constitute a one-parameter family (the parameter being $\unicode[STIX]{x1D6FC}$ with $0\leqslant \unicode[STIX]{x1D6FC}\leqslant 1$, and whose extremal members are simple shear ($\unicode[STIX]{x1D6FC}=0$) and planar extension ($\unicode[STIX]{x1D6FC}=1$)), there are two distinct regimes for scalar (heat or mass) transport at large Péclet numbers ($Pe$) depending on the exterior streamline topology (Krishnamurthy & Subramanian, J. Fluid Mech., vol. 850, 2018, pp. 439–483). When the drop-to-medium viscosity ratio ($\unicode[STIX]{x1D706}$) is larger than a critical value, $\unicode[STIX]{x1D706}_{c}=2\unicode[STIX]{x1D6FC}/(1-\unicode[STIX]{x1D6FC})$, the drop is surrounded by a region of closed streamlines in the inertialess limit ($Re=0$, $Re$ being the drop Reynolds number). Convection is incapable of transporting heat away on account of the near-field closed streamline topology, and the transport remains diffusion limited even for $Pe\rightarrow \infty$. However, weak inertia breaks open the closed streamline region, giving way to finite-$Re$ spiralling streamlines and convectively enhanced transport. For $Re=0$ the closed streamlines on the drop surface, for $\unicode[STIX]{x1D706}>\unicode[STIX]{x1D706}_{c}$, are Jeffery orbits, a terminology originally used to describe the trajectories of an axisymmetric rigid particle in a simple shear flow. Based on this identification, a novel boundary layer analysis that employs a surface-flow-aligned non-orthogonal coordinate system, is used to solve the transport problem in the dual asymptotic limit $Re\ll 1$, $RePe\gg 1$, corresponding to the regime where inertial convection balances diffusion in an $O(RePe)^{-1/2}$ boundary layer. Further, the separation of time scales in the aforementioned limit, between rapid convection due to the Stokesian velocity field and the slower convection by the $O(Re)$ inertial velocity field, allows one to average the convection–diffusion equation over the phase of the Stokesian surface streamlines (Jeffery orbits), allowing a simplification of the original three-dimensional non-axisymmetric transport problem to a form resembling a much simpler axisymmetric one. A self-similar ansatz then leads to the boundary layer temperature field, and the resulting Nusselt number is given by $Nu={\mathcal{H}}(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D706})(RePe)^{1/2}$ with ${\mathcal{H}}(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D706})$ given in terms of a one-dimensional integral; the prefactor ${\mathcal{H}}(\unicode[STIX]{x1D6FC},\unicode[STIX]{x1D706})$ diverges for $\unicode[STIX]{x1D706}\rightarrow \unicode[STIX]{x1D706}_{c}^{+}$ due to assumptions underlying the Jeffery-orbit-averaged analysis breaking down. Although the separation of time scales necessary for the validity of the analysis no longer exists in the transition regime ($\unicode[STIX]{x1D706}$ in the neighbourhood of $\unicode[STIX]{x1D706}_{c}$), scaling arguments nevertheless highlight the manner in which the Nusselt number function connects smoothly across the open and closed streamline regimes for any finite $Pe$.
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Treekitkarnmongkol, Warapen, Vandna Shah, Kazuharu Kai, Hiroshi Katayama, Justin W. Wong, Farah A. Ladha, Brian Menegaz et al. « Abstract A017 : Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer ». Cancer Prevention Research 15, no 12_Supplement_1 (1 décembre 2022) : A017. http://dx.doi.org/10.1158/1940-6215.dcis22-a017.
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Abstract Background: Screening mammography has dramatically increased incidental detection of Ductal Carcinoma in situ (DCIS), a non-obligate precursor of breast cancer. Approximately 10-50% of DCIS progress to the invasive disease and the risk of developing recurrence or progression after surgery is still not well defined based on clinical and pathological characteristics. Our study investigated the genetic and epigenetic mechanisms associated with recurrence and progression of DCIS to invasive cancer. Methods: To identify genes associated with recurrence and progression of DCIS to invasive cancer, we performed Nanostring nCounter analysis (MDACC, n = 40) and RNA-sequencing (Sloane study, n = 183) in two independent prospective primary DCIS cohorts. Mammary epithelial-specific Pten knockout mouse model developed in our lab was used to interrogate the genetic pathway deregulated during development of mammary intraepithelial neoplasia to adenocarcinoma. ATAC-seq and ChIP-qPCR were performed to assess chromatin accessibility in the genome and validate binding of histone-modifying enzymes on target promoters. Histopathological analyses were performed to determine DCIS grades, subtypes, and protein expression profiles. Results: RNA expression profiles of normal mammary and primary DCIS tissues (n = 40) identified 10 gene transcripts that were significantly and differentially expressed between normal and high-grade DCIS. Only SOX11 expression was significantly and progressively correlated with KI67 and the DCIS recurrence score as described by Solin (JNCI 2013). Mammary intraepithelial neoplasia in Pten knockout mice and 21T DCIS to IDC progression cell line model also revealed SOX11 upregulation compared to controls. Since PTEN/PI3K/AKT pathway is known to regulate global active histone marks and open accessible chromatin, we investigated the role of AKT on SOX11 expression. Results demonstrated that inhibition of AKT altered enrichment of histone-modifying enzymes KDM5A and EZH2 on the promoter accompanying downregulated SOX11 expression in DCIS cell lines. SOX11 and EZH2 expression profiles revealed significant correlation in DCIS tissue samples. In two independent DCIS cohorts, SOX11 was found significantly upregulated in HER2+ and basal-like DCIS subtypes (P < 0.001). RNA sequencing in 183 longitudinal DCIS cases of the Sloane study (median follow-up of 96 months) revealed significantly shorter recurrence-free survival in SOX11+ than SOX11- patients (P < 0.02 in all subtypes; P = 0.002 in HER2+ subtype). Based on COX proportional hazards model, SOX11 alone was significantly associated with the risk of developing recurrence and invasive breast cancer (HR = 1.7, 95% CI = 1.1 to 2.6; P < 0.02). Conclusions: Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer. SOX11 and its epigenetic regulators can be developed as prognostic markers for DCIS patients with recurrence risk independent of traditional clinical and pathologic characteristics. Citation Format: Warapen Treekitkarnmongkol, Vandna Shah, Kazuharu Kai, Hiroshi Katayama, Justin W. Wong, Farah A Ladha, Brian Menegaz, Sarah E. Pinder, Wei Lu, Fei Yang, Ximing Tang, Savitri Krishnamurthy, Ignacio I. Wistuba, Elinor J. Sawyer, Alastair M. Thompson, Subrata Sen. Epigenetic activation of SOX11 is associated with recurrence and progression of DCIS to invasive breast cancer [abstract]. In: Proceedings of the AACR Special Conference on Rethinking DCIS: An Opportunity for Prevention?; 2022 Sep 8-11; Philadelphia, PA. Philadelphia (PA): AACR; Can Prev Res 2022;15(12 Suppl_1): Abstract nr A017.
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Ghanbari, Mohammad Hossein, et Bastian J. M. Etzold. « Increasing Sensitivity and Selectivity for Heavy Metal Sensing through Microfluidic Electrochemical Sensor ». ECS Meeting Abstracts MA2023-02, no 62 (22 décembre 2023) : 2944. http://dx.doi.org/10.1149/ma2023-02622944mtgabs.
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Introduction Cadmium usually exists in nature as a compound and under normal environmental conditions, its small content will not affect human health. Nevertheless, with human society's development, heavy metal ions pollution has become substantially serious, and they have serious biological toxicity. Hence, it is important to develop simple, rapid, sensitive, and portable devices for Cd2+ sensing [1]. In the present work, we show how paper based microfluidic sensors improve sensitivity and limit of detection (LOD) in comparison to classical screen-printed carbon-based electrode (SPCE). Furthermore, the presented microfluidic electrochemical carbon-based sensor (μCS) do not employ critical metals and rely on graphite foil that is modified by N-doped carbon nanoonions (N-CNOs) N-CNOs. Experimental For the synthesis of N-doped CNOs the Kuznetsov method was employed [2]. The alignment of the component for μCS device is sketched below. After providing the analyte solution through the sponge the electrochemical detection is carried out through accumulation of the metal at the working electrode for varying times and cathodic potentials. The final detection is carried out through square wave anodic stripping voltammetry (SWASV) of the accumulated metal. Results and discussion To realize a sensitive measurement, some experimental conditions including the optimal amount of the employed N-doped CNOs and Nafion in the nanocomposite, deposition time and potential, and the effect of pH of supporting electrolyte were studied. By increasing the deposition time ranging from 0 to 5 min, the SPCE/N-CNOs signal was increased and after that, it remains roughly constant because the WE surface is being saturated and also the amount of analyte in the droplet was reduced due to the presence of a stagnant flow. However, for μCS/N-CNOs by increasing the accumulation time ranging from 0 to 10 min the signal was increased which shows that the electrode surface is still far from being saturated (because of the live flow). A linear concentration range from 1.0 to 100.0 μg L- 1 was achieved using SWASV. Also, the LOD and sensitivity are calculated to be 0.5 μg L- 1 and 1.02 μA µM-1 cm-2, respectively. Additionally, the method was successfully employed for measurements of Cd2+ in different real samples, which demonstrated the excellent applicability of the device for the adsorption and detection of heavy metal ions. Conclusion The μCS/N-CNOs offers several core advantages over SPCE/N-CNOs in terms of cost, simplicity, analysis time, and sensitivity. These unique advantages are due to the combined microfluidic configuration, 3D electrode layout, and a unique modifier. We believe our findings would have significant implications in developing other portable, fast, and cost-effective electrochemical detection platforms, such as clinical diagnosis and security inspection. References [1]. Fan, Guojing, Dasun Zhai, and Dongsheng Zou. "Highly sensitive electrochemical determination of cadmium (II) in environmental water based on the electrodeposited bismuth nanoparticles." Int. J. Electrochem. Sci 11 (2016): 4362-4370. [2]. Krishnamurthy, S., et al. "In situ formation of onion-like carbon from the evaporation of ultra-dispersed nanodiamonds." Carbon 52 (2013): 145-149. Figure 1