Bibliographies thématiques / Immune humoral response

Littérature scientifique sur le sujet « Immune humoral response »

Auteur : Grafiati
Publié le 25 mai 2024

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Articles de revues sur le sujet "Immune humoral response"

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Banerjee, Dilip K., et G. Richard Hilson. « Humoral immune response in infection ». Current Opinion in Infectious Diseases 4, no 3 (juin 1991) : 325–31. http://dx.doi.org/10.1097/00001432-199106000-00011.

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Ye, Jianmin, Ilsa M. Kaattari, Cuiyan Ma et Stephen Kaattari. « The teleost humoral immune response ». Fish & ; Shellfish Immunology 35, no 6 (décembre 2013) : 1719–28. http://dx.doi.org/10.1016/j.fsi.2013.10.015.

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Skerra, A. « Imitating the humoral immune response ». Current Opinion in Chemical Biology 7, no 6 (décembre 2003) : 683–93. http://dx.doi.org/10.1016/j.cbpa.2003.10.012.

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YANG, HYUN MO. « A MATHEMATICAL MODEL TO ASSESS THE IMMUNE RESPONSE AGAINSTTRYPANOSOMA CRUZIINFECTION ». Journal of Biological Systems 23, no 01 (mars 2015) : 131–63. http://dx.doi.org/10.1142/s0218339015500084.

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A mathematical model is developed to assess humoral and cellular immune responses against Trypanosoma cruzi infection. Analysis of the model shows a unique non-trivial equilibrium, which is locally asymptotically stable, except in the case of a strong cellular response. When the proliferation of the activated CD8 T cells is increased, this equilibrium becomes unstable and a limit cycle appears. However, this behavior can be avoided by increasing the action of the humoral response. Therefore, unbalanced humoral and cellular responses can be responsible for long asymptomatic period, and the control of Trypanosoma cruzi infection is a consequence of well coordinated action of both humoral and cellular responses.
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Palosuo, Tima, et Kimmo Aho. « Humoral Immune Response to Mammalian Allergens ». Allergy and Asthma Proceedings 8, no 4 (1 juillet 1987) : 233–35. http://dx.doi.org/10.2500/108854187779032460.

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C, Prabha, Kripa V. et Sulochana D. Das. « Humoral Immune Response in Tuberculous Pleuritis ». American Journal of Immunology 1, no 2 (1 février 2005) : 68–73. http://dx.doi.org/10.3844/ajisp.2005.68.73.

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van Spriel, Annemiek B. « Tetraspanins in the humoral immune response ». Biochemical Society Transactions 39, no 2 (22 mars 2011) : 512–17. http://dx.doi.org/10.1042/bst0390512.

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The tetraspanins represent a large superfamily of four-transmembrane proteins that are expressed on all nucleated cells. Tetraspanins play a prominent role in the organization of the plasma membrane by co-ordinating the spatial localization of transmembrane proteins and signalling molecules into ‘tetraspanin microdomains’. In immune cells, tetraspanins interact with key leucocyte receptors [including MHC molecules, integrins, CD4/CD8 and the BCR (B-cell receptor) complex] and as such can modulate leucocyte receptor activation and downstream signalling pathways. There is now ample evidence that tetraspanins on B-lymphocytes are important in controlling antibody production. The tetraspanin CD81 interacts with the BCR complex and is critical for CD19 expression and IgG production, whereas the tetraspanin CD37 inhibits IgA production and is important for IgG production. By contrast, the tetraspanins CD9, Tssc6 and CD151 appear dispensable for humoral immune responses. Thus individual tetraspanin family members have specific functions in B-cell biology, which is evidenced by recent studies in tetraspanin-deficient mice and humans. The present review focuses on tetraspanins expressed by B-lymphocytes and discusses novel insights into the function of tetraspanins in the humoral immune response.
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Brooks, G. F., et C. J. Lammel. « Humoral immune response to gonococcal infections. » Clinical Microbiology Reviews 2, Suppl (avril 1989) : S5–10. http://dx.doi.org/10.1128/cmr.2.suppl.s5.

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Brooks, G. F., et C. J. Lammel. « Humoral immune response to gonococcal infections. » Clinical Microbiology Reviews 2, Suppl (1989) : S5–10. http://dx.doi.org/10.1128/cmr.2.suppl.s5-10.1989.

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Grimaldi, M. E., A. Lazzarin, A. Castagna et N. Canal. « Humoral immune response following HIV infection ». Acta Neurologica Scandinavica 79, no 3 (mars 1989) : 258. http://dx.doi.org/10.1111/j.1600-0404.1989.tb03762.x.

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Thèses sur le sujet "Immune humoral response"

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Nissinen, A. (Antti). « Humoral immune response to phosphatidylethanol ». Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295232.

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Abstract Heavy alcohol consumption places a substantial burden on health all over the world. Metabolites of alcohol evoke alterations that lead to tissue damage in many organs. Phosphatidylethanol (PEth) is a unique phospholipid formed in the cellular membranes during the metabolism of ethanol after alcohol consumption. PEth has attracted special attention as it is postulated to be a reliable marker of long term heavy alcohol consumption. The aims of present study were to investigate the immunogenicity of phosphatidylethanol in mice and to analyze the plasma antibodies binding to phosphatidylethanol in humans. In this study a clear immune response was generated in mice immunized with PEth in human low density lipoprotein (LDL) carrier. Mouse monoclonal IgM antibodies binding specifically to phosphoethyl head group of PEth were generated using hybridoma technology. Since PEth was shown to be immunogenic in mice, plasma was analyzed for the presence of antibodies also in humans. PEth-specific antibodies of IgG, IgA and IgM isotypes in plasma were detected in heavy drinkers of alcohol with or without pancreatitis as well as in the controls. The plasma levels of the antibodies binding to PEth were significantly lower in the study subjects with heavy alcohol use and in this present study sample the low IgA levels to PEth were better indicators of heavy alcohol consumption as compared to the some of the traditional markers of heavy alcohol use. The antibody levels to PEth associated significantly to plasma antibodies binding to malondialdehyde-acetaldehyde adducts that are known to be formed during alcohol metabolism but not to antibodies binding to phosphocholine which is generated by lipid oxidation in humans. In conclusion, this study demonstrates that phosphatidylethanol is immunogenic in mice when using carriers such as human LDL in the immunization process. The binding of the monoclonal antibodies specifically to the PEth head group suggests that it would be feasible to develop a diagnostic immunoassay to PEth. The presence of antibodies binding to PEth in plasma indicates that PEth may be a target of humoral immunity in humans
Tiivistelmä Runsas alkoholinkulutus aiheuttaa maailmanlaajuisesti merkittäviä terveydellisiä haittoja. Alkoholin aineenvaihduntatuotteet muuttavat kudoksien rakenteita ja aiheuttavat kudosvaurioita. Fosfatidyylietanoli on alkoholin aineenvaihdunnan tuloksena solukalvoilla syntyvä fosfolipidi, jota on tutkittu kahdenkymmenen vuoden ajan lupaavana alkoholin suurkulutuksen merkkiaineena. Tutkimuksen tavoitteena oli selvittää fosfatidyylietanolin immunisoinnin aiheuttamaa vasta-aineiden muodostumista koe-eläinmallina käytetyissä hiirissä sekä määrittää ihmisten plasmanäytteistä vasta-aineita, jotka sitoutuvat fosfatidyylietanoliin. Tutkimuksessa havaittiin immuunivasteen muodostuminen hiirissä, jotka immunisoitiin ihmisen LDL hiukkasiin liitetyllä fosfatidyylietanolilla. Hiiren monoklonaalisia fosfatidyylietanoliin sitoutuvia IgM-luokan vasta-aineita tuotettiin tutkimuksessa soluviljelyn avulla. Fosfatidyylietanolin aiheuttama vasta-aineiden muodostuminen hiirillä johdatti mittaamaan fosfatidyylietanoliin sitoutuvia vasta-aineita myös ihmisiltä. Tutkimuksessa havaittiin fosfatidyylietanoliin sitoutuvia IgG-, IgA- ja IgM-luokan vasta-aineita alkoholin suurkuluttajilla, alkoholihaimatulehdusta sairastavilla ja verrokkihenkilöillä. Vasta-aineiden pitoisuudet olivat alkoholia runsaasti käyttävillä koehenkilöillä merkitsevästi pienemmät kuin verrokkiryhmällä. Matalat IgA-vasta-ainepitoisuudet osoittautuivat aineistossa paremmaksi alkoholin suurkulutuksen osoittajiksi kuin eräät tavanomaisesti käytetyt alkoholinkäytön merkkiaineet. Plasman fosfatidyylietanoli-vasta-aineiden ja alkoholin aineenvaihdunnan seurauksena syntyvien malondialdehydi-asetaldehydi-addukteihin sitoutuvien vasta-aineiden määrän välillä havaittiin merkitsevä yhteys, jota ei havaittu rasvojen hapettumisen seurauksena syntyvien fosfokoliini-vasta-aineiden ja fosfatidyylietanoli-vasta-aineiden välillä. Tutkimus osoittaa, että hiirillä voidaan aikaansaada vasta-ainevälitteinen immuunivaste, kun ne rokotetaan ihmisen LDL-hiukkaseen liitetyllä fosfatidyylietanolilla. Fosfatidyylietanoliin spesifisesti sitoutuvien monoklonaalisten vasta-aineiden tuottaminen voi tulevaisuudessa johtaa immunologisen diagnostisen määritysmenetelmän kehittämiseen. Fosfatidyylietanoliin sitoutuvien plasman vasta-aineiden havaitseminen viittaa siihen, että fosfatidyylietanoli on vasta-ainevälitteisen immuunivasteen kohde myös ihmisillä
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Barclay, W. S. « The humoral immune response to rhinovirus infection ». Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383380.

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Kummu, O. (Outi). « Humoral immune response to carbamyl-epitopes in atherosclerosis ». Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526205670.

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Abstract Carbamylation of proteins in vivo occurs by cyanate, non-enzymatically when urea is dissociated, and by myeloperoxidase-catalyzed oxidation from thiocyanate. Carbamylation of low-density lipoprotein is suggested to enhance atherogenesis in patients with with chronic kidney disease and uremia. This thesis study assessed the questions of whether healthy humans or uremic patients under enhanced carbamylation have antibodies recognizing carbamyl-epitopes in plasma, and what is their role in vivo. Also, humoral immune response to carbamyl-LDL immunization and its impact on atherogenesis in LDLR-/- mice was investigated. In this thesis study, plasma antibodies to carbamylated proteins were detected in humans, and IgG antibodies to carbamylated proteins were associated with uremia and smoking, conditions with enhanced carbamylation. The human IgG and IgM antibodies binding to carbamyl-epitopes were associated with oxidation-specific epitopes in plasma. Monoclonal Fab antibodies with characteristics of a natural antibody and ability to bind both carbamyl- and malondialdehyde-derived epitopes were cloned from healthy humans. An investigated Fab antibody was able to bind epitopes found in atherosclerotic lesions and inhibit the uptake of modified LDL by macrophages. Human plasma antibodies and the monoclonal Fab bound to epitopes found on apoptotic cells. Human B-cells secreted antibodies with similar cross-reactive binding properties between carbamyl- and malondialdehyde adducts and apoptotic cells in vitro. Immunization with mouse carbamyl-LDL without adjuvant resulted in specific IgG immune response in LDLR-/- mice, but also a cross-reaction with malondialdehyde-adducts was observed. Carbamyl-LDL immunized mice had enhanced plasma antibody binding to apoptotic cells. Carbamyl-LDL immunization did not affect atherogenesis in mice. This thesis demonstrates that IgG antibodies to carbamyl-epitope might serve as a novel indicator of carbamylation in vivo in uremic patients or smokers. The cross-reactivity between antibodies binding to carbamylated and oxidation-specific epitopes, and apoptotic cells may have a role in explaining the link between enhanced atherogenesis and kidney disease
Tiivistelmä Proteiinien karbamylaatiota tapahtuu syanaatin vaikutuksesta. Sitä muodostuu urean hajotessa tai myeloperoksidaasin katalysoimana tiosyanaatin hapettuessa. Low-density lipoproteiinin eli LDL:n karbamylaation on esitetty edistävän valtimonkovettumataudin eli ateroskleroosin kehittymistä munuaisten vajaatoimintaa sairastavilla ureemisilla potilailla. Väitöskirjatyössä tutkittiin, onko terveillä ihmisillä ja ureemisilla potilailla karbamyyli-epitooppeja tunnistavia vasta-aineita, ja mikä niiden merkitys on elimistössä. Humoraalista immuunivastetta karbamyyli-LDL-immunisaation jälkeen sekä sen vaikutusta ateroskleroosin kehittymiseen tutkittiin LDL-reseptoripuutteellisilla hiirillä. Tutkimuksessa osoitettiin, että ihmisillä on plasmassa karbamyloituja proteiineja tunnistavia vasta-aineita. IgG-luokan vasta-aineet ovat yhteydessä uremiaan ja tupakointiin, joissa karbamylaatio on lisääntynyt. Karbamyyli- ja hapettuneita epitooppeja tunnistavien plasman IgG- ja IgM-vasta-aineiden välillä havaittiin olevan yhteys. Työssä kloonattiin terveistä ihmisistä monoklonaalisia Fab-vasta-aineita, joilla on luonnollisten vasta-aineiden kaltaisia ominaisuuksia ja kyky sitoutua sekä karbamyyli- että malonidialdehydi-epitooppeihin. Yksi tutkittu Fab-vasta-aine sitoutui valtimonkovettumataudin ateroomissa oleviin epitooppeihin ja esti muuntuneen LDL:n sisäänoton makrofagi-soluihin. Ihmisen plasman vasta-aineet ja monoklonaalinen Fab-vasta-aine sitoutuivat apoptoottisten solujen pinnalla oleviin rakenteisiin. Soluviljelyolosuhteissa ihmisen B-solut tuottivat vasta-aineita, joilla oli samanlaisia ristireaktio-ominaisuuksia karbamyyli- ja malonidialdehydi-epitooppeja sekä apoptoottisia soluja kohtaan. Karbamyyli-LDL-immunisaatio sai aikaan IgG-immuunivasteen hiirillä karbamyyli-LDL:a kohtaan, mutta myös ristireaktio malonidialdehydi-rakenteita sekä apoptoottisia soluja kohtaan havaittiin. Karbamyyli-LDL-immunisaatio ei vaikuttanut ateroskleroosin kehittymiseen hiirillä. Tutkimus osoittaa, että IgG-vasta-aineet karbamyyli-epitooppeja kohtaan voivat olla uudenlainen karbamylaation merkkiaine elimistössä ureemisilla potilailla ja tupakoitsijoilla. Karbamyloituneiden ja hapettuneiden epitooppien sekä apoptoottisten solujen välillä havaituilla vasta-aineiden ristireaktioilla voi olla merkitystä valtimonkovettumataudin etenemiseen munuaisten vajaatoiminnassa
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Ali, Munaf. « The humoral immune response to SIV recombinant antigens ». Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243412.

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Joller, Nicole Christine. « Humoral immune response to the intracellular pathogen Legionella pneumophila / ». Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17950.

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Douthett, Rebecca L. « Enhancement of the humoral immune response to Pseudomonas aeruginosa ». The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1126903068.

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Skott, Pia. « HIV induced humoral immune response with specific relevance to IgA / ». Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-240-x/.

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Morley, Sarah Louise. « Molecular aspects of the humoral immune response against Neisseria meningitidis ». Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424765.

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Podmore, Michelle. « Microbial targets of the humoral immune response in periodontal disease ». Thesis, University of Glasgow, 2000. http://theses.gla.ac.uk/3915/.

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This thesis reports on investigations carried out to identify the important antigens inducing a humoral immune response in periodontal disease. A number of different techniques were used. The first study examined the systemic immune response, specifically the effects of treatment on the immune response of patients with chronic periodontitis against a panel of periodontal pathogens and a large panel of antigen preparations from these bacteria. The results of the study indicated that there was no difference in antibody titre following treatment against any of the putative periodontal antigenic targets tested. These results conflict with many published reports, however, differences in factors such as length of treatment and antigen preparation often make the comparison of different studies futile. An investigation to examine the phenomenon of cross-reactivity between antibodies induced against putative periodontal pathogens was the second part of this overall project. The results suggested a high proportion of cross-reactivity between the 4 periodontal pathogens P. gingivalis, A. actinomycetemcomitans, P. intermedia and B. forsythus. Results indicating such a high cross-reactivity between these micro-organisms prove that the issue of cross-reactivity is an important one that should be considered when carrying out any immunological and microbiological investigations in this field. Following the above investigations of the systemic immune response the remainder of this thesis is a report of three studies examining the local immune response in periodontal disease.
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Orozco, Johnnie Jose. « Characterizing the humoral immune response to human papillomavirus type 6 / ». Thesis, Connect to this title online ; UW restricted, 2004. http://hdl.handle.net/1773/8108.

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Livres sur le sujet "Immune humoral response"

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M, Snapper Clifford, dir. Cytokine regulation of humoral immunity : Basic and clinical aspects. Chichester : J. Wiley, 1996.

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Hassan, Jubril Olugbenga. Some aspects of humoral and cellular immune response to 'Salmonella typhimurium' in chickens. Birmingham : University of Birmingham, 1989.

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Kachani, Malika. Humoral immune responses in theileria annulata infection. Uxbridge : Brunel University, 1990.

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Manser, Tim, dir. Specialization and Complementation of Humoral Immune Responses to Infection. Berlin, Heidelberg : Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-73900-5.

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Tim, Manser, dir. Specialization and complementation of humoral immune responses to infection. Berlin : Springer, 2007.

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Allen, Stephen John. An epidemiological study of humoral and cell-mediated immune responses to defined plasmodium falciparum vaccine candidate antigens and their role in protection against infection in a rural area of The Gambia. Birmingham : University of Birmingham, 1991.

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1938-, Goidl Edmond A., dir. Aging and the immune response : Cellular and humoral aspects. New York : Dekker, 1987.

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Goidl, Edmond A. Aging and the Immune Response : Cellular and Humoral Aspects (Immunology Series). Marcel Dekker, 1986.

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Wood, Patricia A. Characterization of the humoral immune response to Renibacterium salmonarium in Chinook salmon Oncorhynchus tshawytscha. 1994.

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Cytokine Regulation of Humoral Immunity : Basic and Clinical Aspects. Wiley, 1996.

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Chapitres de livres sur le sujet "Immune humoral response"

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Harr, Jeffrey N., Philip F. Stahel, Phillip D. Levy, Antoine Vieillard-Baron, Yang Xue, Muhammad N. Iqbal, Jeffrey Chan et al. « Humoral Immune Response ». Dans Encyclopedia of Intensive Care Medicine, 1157. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_3149.

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Gooch, Jan W. « Humoral Immune Response ». Dans Encyclopedic Dictionary of Polymers, 899. New York, NY : Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13952.

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Patrussi, Laura, Nagaja Capitani, Mario Milco D’Elios et Cosima T. Baldari. « The B-Side of the Immune Response ». Dans Humoral Primary Immunodeficiencies, 1–20. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-91785-6_1.

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Landini, Maria Paola, Tiziana Lazzarotto et Paola Dal Monte. « Humoral Immune Response to Human Cytomegalovirus ». Dans Molecular Biology of Hematopoiesis 5, 313–22. Boston, MA : Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_38.

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Gemeiner, M., E. Leidinger, I. Miller et L. Moroder. « Humoral immune response to synthetic immunoadjuvants ». Dans Peptides 1990, 855–56. Dordrecht : Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_352.

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Egelkrout, Erin M., et Denise A. Galloway. « The Humoral Immune Response to Human Papillomavirus ». Dans The Papillomaviruses, 277–312. Boston, MA : Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-36523-7_12.

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Żaczek, Maciej, Marzanna Łusiak-Szelachowska, Beata Weber-Dąbrowska, Ryszard Międzybrodzki, Wojciech Fortuna, Paweł Rogóż, Sławomir Letkiewicz et Andrzej Górski. « Humoral Immune Response to Phage-Based Therapeutics ». Dans Phage Therapy : A Practical Approach, 123–43. Cham : Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26736-0_5.

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Snapper, Clifford M., Jesus Colino, Abdul Q. Khan et Zheng Qi Wu. « The Humoral Immune Response to Streptococcus Pneumoniae ». Dans The Pneumococcus, 367–81. Washington, DC, USA : ASM Press, 2014. http://dx.doi.org/10.1128/9781555816537.ch23.

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Bardare, Maria, Maria Barbi, Anna Plebani, Gabriele Ferraris et Alessandro Remo Zanetti. « Humoral Response to Inactivated Poliovaccine in Anti-HIV Positive Infants ». Dans The Immune Response to Viral Infections, 221–24. Boston, MA : Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5712-4_21.

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Gissmann, Lutz. « Humoral Immune Response to Genital Human Papillomavirus Infections ». Dans Immunology of Human Papillomaviruses, 81–84. Boston, MA : Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2449-6_15.

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Actes de conférences sur le sujet "Immune humoral response"

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SHAHAF, GITIT, MICHAL BARAK, NETA ZUCKERMAN et RAMIT MEHR. « THE HUMORAL IMMUNE RESPONSE : COMPLEXITY AND THEORETICAL CHALLENGES ». Dans BIOMAT 2010 - International Symposium on Mathematical and Computational Biology. WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/9789814343435_0018.

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Kisakova, L. A., D. N. Kisakov, V. A. Yakovlev, E. V. Tigeeva, M. B. Borgoyakova, K. P. Makarova, A. P. Rudometov et L. I. Karpenko. « SPECIFIC HUMORAL IMMUNE RESPONSE IN SYRIAN HAMSTERS IMMUNIZED WITH PVAXRBD DNA VACCINE USING JET INJECTION ». Dans X Международная конференция молодых ученых : биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-329.

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The research was made of the humoral response in Syrian hamsters after immunization with an experimental DNA vaccine pVAXrbd encoding the RBD of the S protein of the SARS-CoV-2 virus, introduced using a needleless injector. It was shown that the median titers of antibodies specific to RBD in the sera of immunized animals reached 1:55050, which confirms the formation of a virus-specific humoral immune response.
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van Parys, Alexander, Filip Boyen, E. Verbrugghe, Bregje Leyman, Freddy Haesebrouck et F. Pasmans. « Salmonella Typhimurium interference with the humoral immune response of pigs ». Dans Fifth International Symposium on the Epidemiology and Control of Foodborn Pathogens in Pork. Iowa State University, Digital Press, 2011. http://dx.doi.org/10.31274/safepork-180809-576.

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Oliveira, Laura, Camila Corsini, Rafaella Queiroz, Alessandro Correa, Thiago Jesus, Letícia Martins, Miguel Bortolini, Ernesto Taketomi et Rafael Resende. « Humoral immune response of allergic subjects vaccinated against COVID-19 ». Dans International Symposium on Immunobiologicals. Instituto de Tecnologia em Imunobiológicos, 2023. http://dx.doi.org/10.35259/isi.2023_57961.

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Tent, Michiel. « Original antigenic sin influences humoral immune response to SARS-CoV-2 ». Dans AAN 2023, sous la direction de Prof Hans-Peter Hartung. Baarn, the Netherlands : Medicom Medical Publishers, 2023. http://dx.doi.org/10.55788/54417a4f.

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Krasochko, P. A., M. A. Ponaskov, I. A. Krasochko, A. D. Zaberezhnyi et V. I. Eremets. « CELLULAR AND HUMORAL IMMUNE RESPONSE IN COWS IMMUNIZED WITH INFECTIOUS PNEUMOENTERITIS VACCINES ». Dans НАУЧНЫЕ ОСНОВЫ ПРОИЗВОДСТВА И ОБЕСПЕЧЕНИЯ КАЧЕСТВА БИОЛОГИЧЕСКИХ ПРЕПАРАТОВ. Лосино-Петровский : Б. и., 2022. http://dx.doi.org/10.47804/9785899040313_2022_40.

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Al-Khalaifah, Hanan. « HUMORAL IMMUNE RESPONSE OF HAEMOCYTES, RESPRESENTED BY NITRIC OXIDE AND PHENOL OXIDASE PRODUCTION ». Dans 18th International Multidisciplinary Scientific GeoConference SGEM2018. Stef92 Technology, 2018. http://dx.doi.org/10.5593/sgem2018/6.2/s25.030.

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Allaf, L. Al, A. Chechushkov, T. Ushakova, V. Morozova et N. Tikunova. « INFLUENCE OF HUMORAL IMMUNE RESPONSE TO BACTERIOPHAGE ON PHAGE-THERAPY AND ANTI-BACTERIAL IMMUNITY ». Dans X Международная конференция молодых ученых : биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-223.

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We demonstrated that although phage therapy with PM16 leads to the formation of anti-phage neutralizing antibodies in balb/c mice, it may boost the organism humoral response against its host, p. mirabilis. On the other hand, injecting balb/c mice with p.mirabilis increases the level of anti-PM16 antibodies, even in mice without previous encounter with PM16.
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Ghanem, Maha K., Nour Eldin H. M. Imam, Hebat Allah Rashed et Azza Ezz ElDin. « Cellular and humoral immune response in non HIV infected tuberculous patients in Upper Egypt ». Dans Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.oa3483.

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Triolo, G., A. Accardo-Palumbo, F. Ciccia, A. Ferrante, C. Mantione, E. Giardina et G. Licata. « FRI0161 Humoral and cell-mediated immune response to cow’s milk proteins in behÇet’s disease ». Dans Annual European Congress of Rheumatology, Annals of the rheumatic diseases ARD July 2001. BMJ Publishing Group Ltd and European League Against Rheumatism, 2001. http://dx.doi.org/10.1136/annrheumdis-2001.221.

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Rapports d'organisations sur le sujet "Immune humoral response"

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Noga, Edward J., Ramy R. Avtalion et Michael Levy. Comparison of the Immune Response of Striped Bass and Hybrid Bass. United States Department of Agriculture, août 1993. http://dx.doi.org/10.32747/1993.7568749.bard.

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We developed methods for examining the pathophysical response of striped bass and hybrid bass to various forms of stress. This involved development of techniques for the measurement of lysozyme, mitogen blastogenesis, mixed lymphocyte reaction, and oxidative burst, which are important general indicators of systemic immune function. We also examined local immune defenses (epithelial integrity), as well as homeostatic indicators in blood, including osmotic balance and glucose. Acute stress resulted in significant perturbations in a number of parameters, including glucose, electrolytes, osmolarity, lysozyme, and mixed lymphocyte reaction. Most significantly, acute confinement stress resulted in severe damage to the epidermal epithelium, as indicated by the rapid (within 2 hr) development of erosions and ulcerations on various fins. There were significant differences in the resting levels of some immune functions between striped bass and hybrid bass, including response to mitogens in the leukocyte blastogenesis test. Our studies also revealed that there were significant differences in how striped bass and hybrid bass respond to stress, with striped bass being much more severely affected by stress than the hybrid. This was reflected in more severe changes in glucose, cortisol dynamics, and plasma lysozyme. Most significantly, striped bass developed more severe idiopathic skin ulceration after stress, which may be a major reason why this fish is so prone to develop opportunistic bacterial and fungal infections after stress. Hybrid bass injected with equine serum albumin developed a typical humoral immune response, with peak antibody production 28 days after primary immunization. Fish that were exposed to a chronic stress after a primary immunization showed almost complete inhibition of antibody production.
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Eldar, Avigdor, et Donald L. Evans. Streptococcus iniae Infections in Trout and Tilapia : Host-Pathogen Interactions, the Immune Response Toward the Pathogen and Vaccine Formulation. United States Department of Agriculture, décembre 2000. http://dx.doi.org/10.32747/2000.7575286.bard.

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In Israel and in the U.S., Streptococcus iniae is responsible for considerable losses in various fish species. Poor understanding of its virulence factors and limited know-how-to of vaccine formulation and administration are the main reasons for the limited efficacy of vaccines. Our strategy was that in order to Improve control measures, both aspects should be equally addressed. Our proposal included the following objectives: (i) construction of host-pathogen interaction models; (ii) characterization of virulence factors and immunodominant antigens, with assessment of their relative importance in terms of protection and (iii) genetic identification of virulence factors and genes, with evaluation of the protective effect of recombinant proteins. We have shown that two different serotypes are involved. Their capsular polysaccharides (CPS) were characterized, and proved to play an important role in immune evasion and in other consequences of the infection. This is an innovative finding in fish bacteriology and resembles what, in other fields, has become apparent in the recent years: S. iniae alters surface antigens. By so doing, the pathogen escapes immune destruction. Immunological assays (agar-gel immunodiffusion and antibody titers) confirmed that only limited cross recognition between the two types occurs and that capsular polysaccharides are immunodominant. Vaccination with purified CPS (as an acellular vaccine) results in protection. In vitro and ex-vivo models have allowed us to unravel additional insights of the host-pathogen interactions. S. iniae 173 (type II) produced DNA fragmentation of TMB-8 cells characteristic of cellular necrosis; the same isolate also prevented the development of apoptosis in NCC. This was determined by finding reduced expression of phosphotidylserine (PS) on the outer membrane leaflet of NCC. NCC treated with this isolate had very high levels of cellular necrosis compared to all other isolates. This cellular pathology was confirmed by observing reduced DNA laddering in these same treated cells. Transmission EM also showed characteristic necrotic cellular changes in treated cells. To determine if the (in vitro) PCD/apoptosis protective effects of #173 correlated with any in vivo activity, tilapia were injected IV with #173 and #164 (an Israeli type I strain). Following injection, purified NCC were tested (in vitro) for cytotoxicity against HL-60 target cells. Four significant observations were made : (i) fish injected with #173 had 100-400% increased cytotoxicity compared to #164 (ii) in vivo activation occurred within 5 minutes of injection; (iii) activation occurred only within the peripheral blood compartment; and (iv) the isolate that protected NCC from apoptosis in vitro caused in vivo activation of cytotoxicity. The levels of in vivo cytotoxicity responses are associated with certain pathogens (pathogen associated molecular patterns/PAMP) and with the tissue of origin of NCC. NCC from different tissue (i.e. PBL, anterior kidney, spleen) exist in different states of differentiation. Random amplified polymorphic DNA (RAPD) analysis revealed the "adaptation" of the bacterium to the vaccinated environment, suggesting a "Darwinian-like" evolution of any bacterium. Due to the selective pressure which has occurred in the vaccinated environment, type II strains, able to evade the protective response elicited by the vaccine, have evolved from type I strains. The increased virulence through the appropriation of a novel antigenic composition conforms with pathogenic mechanisms described for other streptococci. Vaccine efficacy was improved: water-in-oil formulations were found effective in inducing protection that lasted for a period of (at least) 6 months. Protection was evaluated by functional tests - the protective effect, and immunological parameters - elicitation of T- and B-cells proliferation. Vaccinated fish were found to be resistant to the disease for (at least) six months; protection was accompanied by activation of the cellular and the humoral branches.
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Chejanovsky, Nor, et Bruce A. Webb. Potentiation of Pest Control by Insect Immunosuppression. United States Department of Agriculture, janvier 2010. http://dx.doi.org/10.32747/2010.7592113.bard.

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The restricted host range of many baculoviruses, highly pathogenic to Lepidoptera and non-pathogenic to mammals, limits their use to single or few closely related Lepidopteran species and is an obstacle to extending their implementation for pest control. The insect immune response is a major determinant of the ability of an insect pathogen to efficiently multiply and propagate. We have developed an original model system to study the Lepidopteran antiviral immune response based on Spodoptera littoralis resistance to AcMNPV (Autographa californica multiple nucleopolyhedrovirus) infection and the fascinating immunosuppressive activity of polydnaviruses .Our aim is to elucidate the mechanisms through which the immunosuppressive insect polydnaviruses promote replication of pathogenic baculoviruses in lepidopteran hosts that are mildly or non-permissive to virus- replication. In this study we : 1- Assessed the extent to which and the mechanisms whereby the immunosuppressive Campoletis sonorensis polydnavirus (CsV) or its genes enhanced replication of a well-characterized pathogenic baculovirus AcMNPV, in polydnavirus-immunosuppressedH. zea and S. littoralis insects and S. littoralis cells, hosts that are mildly or non-permissive to AcMNPV. 2- Identified CsV genes involved in the above immunosuppression (e.g. inhibiting cellular encapsulation and disrupting humoral immunity). We showed that: 1. S. littoralis larvae mount an immune response against a baculovirus infection. 2. Immunosuppression of an insect pest improves the ability of a viral pathogen, the baculovirus AcMNPV, to infect the pest. 3. For the first time two PDV-specific genes of the vankyrin and cystein rich-motif families involved in immunosuppression of the host, namely Pvank1 and Hv1.1 respectively, enhanced the efficacy of an insect pathogen toward a semipermissive pest. 4. Pvank1 inhibits apoptosis of Spodopteran cells elucidating one functional aspect of PDVvankyrins. 5. That Pvank-1 and Hv1.1 do not show cooperative effect in S. littoralis when co-expressed during AcMNPV infection. Our results pave the way to developing novel means for pest control, including baculoviruses, that rely upon suppressing host immune systems by strategically weakening insect defenses to improve pathogen (i.e. biocontrol agent) infection and virulence. Also, we expect that the above result will help to develop systems for enhanced insect control that may ultimately help to reduce transmission of insect vectored diseases of humans, animals and plants as well as provide mechanisms for suppression of insect populations that damage crop plants by direct feeding.
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Leitner, Gabriel, et Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, janvier 2009. http://dx.doi.org/10.32747/2009.7709880.bard.

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Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post second immunization. rTRAP vaccine also elicited a cell-mediated immune response (memory CD4+ and CD8+ T cells), as determined by lymphocyte proliferation assays. The rTRAP vaccine was efficacious as at parturition, only 13.5% heifers in the immunized group were infected with Staphylococcus chromogenes as compared to 42.9% in the non immunized group. Additionally, when cows were immunized in mid-lactation, the difference between somatic cell count (SCC) in immunized and control animals was profound (45±7 vs. 470±194, respectively). At the same time, the difference in milk yield was also evident (48.3±1.4 vs. 44.3±0.9 l/day, respectively). Put together, these studies indicate the value of the rTRAP vaccine in preventing new udder infections by staphylococci, which significantly lead to lowered SCC and some increase in milk yield. TRAP is conserved among all strains and species and is constitutively expressed in any strain of S. aureus or CNS tested so far, including those isolated from cows. TRAP may thus serve as a universal anti-staphylococcus vaccine.
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Leitner, Gabriel, et Naomi Balaban. Novel Immunotherapeutic Agent for the Treatment and Prevention of Staphylococcal Mastitis in Dairy Cows. United States Department of Agriculture, janvier 2009. http://dx.doi.org/10.32747/2009.7695866.bard.

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Staphylococci are the most common and costly mammary disease of dairy cattle worldwide. TRAP, a membrane associated 167AA protein, is highly conserved among staphylococci. The aims of this study were to test the safety and efficacy of recombinant TRAP (rTRAP) vaccine in dairy animals. The vaccine was safe as 2-3 subcutaneous injections of rTRAP (54–100μg) with adjuvant ISA 206 to cows and goats did not lead to any abnormal symptoms of sensitivity to the vaccine. The rTRAP vaccine was immunogenic and caused the induction of a humoral immune response that remained high for at least 160 days post second immunization. rTRAP vaccine also elicited a cell-mediated immune response (memory CD4+ and CD8+ T cells), as determined by lymphocyte proliferation assays. The rTRAP vaccine was efficacious as at parturition, only 13.5% heifers in the immunized group were infected with Staphylococcus chromogenes as compared to 42.9% in the non immunized group. Additionally, when cows were immunized in mid-lactation, the difference between somatic cell count (SCC) in immunized and control animals was profound (45±7 vs. 470±194, respectively). At the same time, the difference in milk yield was also evident (48.3±1.4 vs. 44.3±0.9 l/day, respectively). Put together, these studies indicate the value of the rTRAP vaccine in preventing new udder infections by staphylococci, which significantly lead to lowered SCC and some increase in milk yield. TRAP is conserved among all strains and species and is constitutively expressed in any strain of S. aureus or CNS tested so far, including those isolated from cows. TRAP may thus serve as a universal anti-staphylococcus vaccine.
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Chejanovsky, Nor, et Bruce A. Webb. Potentiation of pest control by insect immunosuppression. United States Department of Agriculture, juillet 2004. http://dx.doi.org/10.32747/2004.7587236.bard.

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Our original aims were to elucidate the mechanisms through which the immunosuppressive insect virus, the Campoletis sonorensis polydnavirus (CsV) promotes replication of a well-characterized pathogenic virus, the Autographa californica multiple nucleopolyhedrovirus (AcMNPV) in hosts that are mildly or non-permissive to virus replication. According to the BARD panels criticism we modified our short-term goals (see below). Thus, in this feasibility study (one-year funding) we aimed to show that: 1. S. littoralis larvae mount an immune response against a baculovirus infection. 2. Immunosuppression of an insect pest improves the ability of a viral pathogen (a baculovirus) to infect the pest. 3. S. littoralis cells constitute an efficient tool to study some aspects of the anti- viral immune response. We achieved the above objectives by: 1. Finding melanized viral foci upon following the baculoviral infection in S . littoralis larvae infected with a polyhedra - positive AcMNPV recombinant that expressed the GFP gene under the control of the Drosophila heat shock promoter. 2. Studying the effect of AcMNPV-infection in S . littoralis immunosuppressed by parasitation with the Braconidae wasp Chelonus inanitus that bears the CiV polydna virus, that resulted in higher susceptibility of S. littoralis to AcMNPV- infection. 3. Proving that S. littoralis hemocytes resist AcMNPV -infection. 4. Defining SL2 as a granulocyte-like cell line and demonstrating that as littoralis hemocytic cell line undergoes apoptosis upon AcMNPV -infection. 5. Showing that some of the recombinant AcMNPV expressing the immuno-suppressive polydna virus CsV- vankyrin genes inhibit baculoviral-induced lysis of SL2 cells. This information paves the way to elucidate the mechanisms through which the immuno- suppressive polydna insect viruses promote replication of pathogenic baculoviruses in lepidopteran hosts that are mildly or non-permissive to virus- replication by: - Assessing the extent to which and the mechanisms whereby the immunosuppressive viruses, CiV and CsV or their genes enhance AcMNPV replication in polydnavirus- immunosuppressed H. zea and S. littoralis insects and S. littoralis cells. - Identifying CiV and CsV genes involved in the above immunosuppression (e.g. inhibiting cellular encapsulation and disrupting humoral immunity). This study will provide insight to the molecular mechanisms of viral pathogenesis and improve our understanding of insect immunity. This knowledge is of fundamental importance to controlling insect vectored diseases of humans, animals and plants and essential to developing novel means for pest control (including baculoviruses) that strategically weaken insect defenses to improve pathogen (i.e. biocontrol agent) infection and virulence.
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Gershoni, Jonathan M., David E. Swayne, Tal Pupko, Shimon Perk, Alexander Panshin, Avishai Lublin et Natalia Golander. Discovery and reconstitution of cross-reactive vaccine targets for H5 and H9 avian influenza. United States Department of Agriculture, janvier 2015. http://dx.doi.org/10.32747/2015.7699854.bard.

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Research objectives: Identification of highly conserved B-cell epitopes common to either H5 or H9 subtypes of AI Reconstruction of conserved epitopes from (1) as recombinantimmunogens, and testing their suitability to be used as universal vaccine components by measuring their binding to Influenza vaccinated sera of birds Vaccination of chickens with reconstituted epitopes and evaluation of successful vaccination, clinical protection and viral replication Development of a platform to investigate the dynamics of immune response towards infection or an epitope based vaccine Estimate our ability to focus the immune response towards an epitope-based vaccine using the tool we have developed in (D) Summary: This study is a multi-disciplinary study of four-way collaboration; The SERPL, USDA, Kimron-Israel, and two groups at TAU with the purpose of evaluating the production and implementation of epitope based vaccines against avian influenza (AI). Systematic analysis of the influenza viral spike led to the production of a highly conserved epitope situated at the hinge of the HA antigen designated “cluster 300” (c300). This epitope consists of a total of 31 residues and was initially expressed as a fusion protein of the Protein 8 major protein of the bacteriophagefd. Two versions of the c300 were produced to correspond to the H5 and H9 antigens respectively as well as scrambled versions that were identical with regard to amino acid composition yet with varied linear sequence (these served as negative controls). The recombinantimmunogens were produced first as phage fusions and then subsequently as fusions with maltose binding protein (MBP) or glutathioneS-transferase (GST). The latter were used to immunize and boost chickens at SERPL and Kimron. Furthermore, vaccinated and control chickens were challenged with concordant influenza strains at Kimron and SEPRL. Polyclonal sera were obtained for further analyses at TAU and computational bioinformatics analyses in collaboration with Prof. Pupko. Moreover, the degree of protection afforded by the vaccination was determined. Unfortunately, no protection could be demonstrated. In parallel to the main theme of the study, the TAU team (Gershoni and Pupko) designed and developed a novel methodology for the systematic analysis of the antibody composition of polyclonal sera (Deep Panning) which is essential for the analyses of the humoral response towards vaccination and challenge. Deep Panning is currently being used to monitor the polyclonal sera derived from the vaccination studies conducted at the SEPRL and Kimron.
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Splitter, Gary, et Menachem Banai. Attenuated Brucella melitensis Rough Rev1 Vaccine. United States Department of Agriculture, janvier 2004. http://dx.doi.org/10.32747/2004.7585199.bard.

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The original objectives of the proposal were: 1. Compare mutants 444 and 710 to Rev1 (parent strain), and 16M (field strain) in murine and human macrophage lines for phenotypic differences. 2. Determine in vivo virulence and survival of the mutants 444 and 710 in guinea pigs and mice. 3. Determine humoral and cell-mediated immune responses induced by mutants 444 and 710 in guinea pigs and mice. 4. Determine in vivo protection of mice and guinea pigs provided by mutants 444 and 710 compared to Rev1. Background: While human and animal brucellosis are rare in the U.S., brucellosis caused by B. melitensis remains relatively constant in Israel. Despite a national campaign to control brucellosis in Israel, the misuse of Rev1 Elberg vaccine strain among pregnant animals has produced abortion storms raising concern of human infection due to vaccine excretion in the milk. Further, some commercial Rev1 vaccine lots can: a) produce persistent infection, b) infect humans, c) be horizontally transmitted, d) cause abortion, and e) induce a persistent anti-O-polysaccharide antibody response confounding the distinction between infected and vaccinated animals. In Israel, vaccination practices have not optimally protected the milk supply from Brucella and Rev 1 vaccine can exacerbate the problem. In addition, cattle vaccinated against B. abortus are not protected against B. melitensis supporting the need for an improved vaccine. A safe vaccine used in adult animals to produce herd resistance to infection and a vaccine that can be distinguished from virulent infection is needed. A rough Rev1 vaccine would be less virulent than the parental smooth strain and permit serologic distinction between vaccinated and infected animals. Advantages of the Rev1 vaccine foundation are: 1) Rev1 vaccination of sheep and goats against B. melintensisis approved; therefore, vaccines derived from the Rev1 foundation may be readily accepted by licensing agencies as well as commercial companies, and 2) considerable data exists on Rev1vaccination and Rev1 proteins. Therefore, a post-genomic vaccine against B. melitensis based on the Rev1 foundation would provide a great advantage. Major conclusions from our work are: 1) We have determined that mutant 710 is highly attenuated in macrophages compared to virulent field strain 16M and mutant 444. 2) We have confirmed that mutant 710 is highly attenuated in guinea pigs and mice. 3) We have determined immune responses induced by mutant 710 in animals. 4) We have determined in vivo protection of mice and guinea pigs provided by mutants 444 and 710 compared to Rev1, and importantly, mutant 710 provides a high level of protection against challenge with virulent B. melitensis 16M. Thus, our data support the goals of the grant and provide the foundation for a future vaccine useful against B. melitensis in Israel. Because of patent considerations, many of our findings with 444 and 710 have not yet been published. Scientific and Agricultural Implications: Our findings support the development of a vaccine against B. melitensis based on the mutant 710. Because strain 710 is a mutant of the Elberg Rev1 vaccine, commercialization is more likely than development of an entirely new, uncharacterized Brucella mutant or strain.
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