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EROL, GIZEM. « Glycan-coated nanoparticles as inhibitors of specific lectins, a new neuroprotective therapeutic strategy for brain injury caused by ischemia ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/403116.
Texte intégralGlycans are chain-like structures of many monosaccharides which create the carbohydrate portion of glycoconjugates such as a glycoproteins, glycolipids, or proteoglycans, and are involved in many physiological functions. Glycans exposed on the surface of pathogens (pathogen-associated molecular patterns, PAMPs) are recognized by the lectin pathway of the complement system, one of the key components of innate immune system, through carbohydrate-binding lectins, such as mannose binding lectin (MBL) or ficolins. Experimental and clinical evidences indicate that MBL also drives secondary pathogenic thrombo-inflammation on the ischemic vasculature. MBL-mediated pathogenesis is initiated by its binding to the sugar moieties exposed on endothelial cell membranes after brain ischemia (damage-associated molecular patterns, DAMPs), e.g. induced by stroke. Stroke is a major cause of disabilities and death worldwide and occurs by blockage or rupture of a brain artery (ischemic or hemorrhagic stroke), with lack of oxygen supply to brain tissues and sudden death of brain cells. Ischemic stroke is the most common type, i.e. 88% of all the cases. Pathological events on the ischemic vessels include the activation of coagulation, contact/kinin, and complement cascades. However, despite recent substantial progress in prevention and management, stroke still remains a large unmet medical need. Therefore, novel therapeutic strategies are needed and MBL inhibitors have been proposed as potential neuroprotective agents. The main goal of this thesis was to identify potential MBL inhibitors, by developing and exploiting a robust pipeline of preclinical studies. At first, an in vitro Surface Plasmon Resonance (SPR)-based assay was developed to identify MBL ligands/inhibitors and determine their affinities for MBL. The novel assay was extensively characterized and proved to be reliable and convenient. The results obtained with different ligands (e.g. monomeric mannose, a new glycan carrying nine mannose residues and mannose-coated gold nanoparticles (Man-GNPs)) confirmed that multivalency markedly increases the affinity. Accordingly, Man-GNPs were selected as the best MBL-binding ligand for the following studies, which were carried out in a cell model mimicking the ischemic injury. i.e. immortalized human brain vascular endothelial cells (i-hBMECs) subjected to hypoxia and re-oxygenated in the presence of MBL. At first, a novel Quartz Crystal Microbalance (QCM)-based biosensor assay was developed which showed that mannose and N-acetylglucosamine —i.e. target sugars of MBL— are actually overexpressed by cells following hypoxic conditions. Consistently, it was observed that deposition of MBL on the cell surface is increased by hypoxia and this effect is counteracted by Man-GNPs, at non- toxic concentrations (20 ug/mL). Further studies showed that hypoxic cells overexpress inflammatory genes, in particular ICAM-1, in a MBL-dependent manner and this effect was prevented by Man-GNPs. These results prompted to test Man-GNPs in vivo, in mice expressing human MBL (hMBL KI) and subjected to transient cerebral arterial occlusion, to have a mice model of stroke. The administration of Man-GNPs to these mice did not result in toxic effects but also did not protect from the MBL-dependent stroke effects. In conclusion, the work described in this thesis provides a full and robust pipeline for the preclinical studies of MBL inhibitors, with potential anti-stroke activities. Among MBL inhibitors, Man-GNPs were identified in vitro as the most promising one, and cell studies confirmed their ability to prevent MBL targeting to hypoxia-induced DAMPs, and the following inflammatory profile. However, the initial studies did not confirm efficacy in vivo, possibly for pharmacokinetic reasons which need to be further clarified.
Hailegebriel, Debebe. « Prosecution of genocide at international and national courts : a comparative analysis of approaches by ICTY/ICTR and Ethiopia/Rwanda ». Diss., University of Pretoria, 2003. http://hdl.handle.net/2263/1072.
Texte intégralThesis (LLM (Human Rights and Democratisation in Africa)) -- University of Pretoria, 2003.
Prepared under the supervision of Dr. Henry Onoria at the Faculty of Law, Makerere University, Kampala
http://www.chr.up.ac.za/academic_pro/llm1/dissertations.html
Centre for Human Rights
LLM
Ciaghi, Aaron. « Standardizing ICT for Development : Towards the Definition of a Standard Process and Maturity Model for ICTD Projects ». Doctoral thesis, Università degli studi di Trento, 2014. https://hdl.handle.net/11572/368172.
Texte intégralLindemann, Lena [Verfasser]. « Referral of Cases from International to National Criminal Jurisdictions : Transferring Cases from the ICTY and the ICTR to National Jurisdictions / Lena Lindemann ». Baden-Baden : Nomos Verlagsgesellschaft mbH & ; Co. KG, 2013. http://d-nb.info/1110056044/34.
Texte intégralThurston, Michael D. « Should We Press the Victims : The Uneven Support for International Criminal Tribunals ». Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/political_science_theses/33.
Texte intégralCoetzee, Coenraad J. W. « ICT convergence : impact on Namibian ICT operators ». Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19806.
Texte intégralToday we face a reality where existing power relations concerning economical, political and cultural institutions and forces are changing. It is about more than just the right to use a technology in itself; it is a matter of having, or not having, access to infonnation and knowledge. The use of information and communications technology (lCT) is an important and powerful tool when it comes to distributing and sharing these resources (Bridges.arg, 2006). The unequal distribution of and the differences in the possibility to use rer effectively are often referred to by the term digital divide (DDN, 2006). Does this sound quite pessimistic? However, a change is taking place since all countries on earth from the richest to the poorest are actually increasing their Ier usage. The problem is that the developed countries are using convergence (three separate communication sectors: information technology, telecommunications and broadcasting merging to become a single communication service sector) to escalate their access to and use of ICf at a much higher speed, which in fact widens the digi tal divide instead of shrinking it (Bridges.org, 2006). Today no country can afford to neglect investments in ICf if it wishes to raise its living standards or to prevent it from being left behind as other countries exploits the possibilities of ICf. Why is ICf considered to be an effective tool for bridging the international digita1 divide? On the United Nations Development Programme's website one can read: " .. .ICf is an increasi ngly powerful tool for participating in global markets; promoting political accountability; improving the delivery of basic services; and enhancing local development opportunities" (UNOP, 2003). These aspects can be of great importance for developing countries in their effort to gain economic development and improvements. Furthermore, it is also a question about every human's right to have access to infonnation (Sida, 2004). According to Steve Case (AOL Time Warner, Chainnan of the Board) every decade has some word associated with it. In the 'SOs, it was the PC. In the '90s, it was the Internet. For the rest of this decade, the key word is going to be convergence (Thompson, 2003). In Namibia a digital divide exists between income groups as well as between the country's rural and urban population. Namibia is sti ll far from providing equal access to information, but Namibia is well positioned to deploy ICf to its advantage. Namibia has a functional telecommunication infrastructure, political stability and an attractive economic environment for investors. However. the geographic and social challenges of Namibia require innovative approaches and considerable effort. Competition and convergence will improve the situation. recommended to expand the set of potential drivers and specifically focus on the relation between convergence and economic growth.
Chen, Jane Y. « Stress in ICU and non-ICU nurses ». Thesis, Boston University, 1988. https://hdl.handle.net/2144/38019.
Texte intégralPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Nurses are subjected to occupational stress factors that can result in the syndrome of burnout. This study compared levels of burnout in nurses in a medical-surgical ICU setting to those in non-ICU medical-surgical settings. A randomized sample of 40 nurses of an urban hospital in Taiwan, twenty nurses in an ICU and 20 in five non-ICU settings (general medical-surgical wards), who returned the questionnaire used to measure burnout, were included in the study. The instrument utilized was the Staff Burnout Scale for Health Professionals. The study found no significant difference in levels of burnout in the two groups. Both groups in this study experienced a higher level of burnout than was reported in other studies in United States literature. In particular, two general medical-surgical wards which had high patient/nurse ratios, had very high levels of burnout. The study also found that all nurses with lower educational levels and ICU nurses with more years of work experience had more burnout.
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Abbasi, Salma. « Women and ICT in Muslim countries : policies, practices and challenges ». Thesis, Royal Holloway, University of London, 2012. http://repository.royalholloway.ac.uk/items/5d56f72f-4ce5-4a5f-7196-22bc9ff0bec1/7/.
Texte intégralBaduza, Gugulethu Qhawekazi. « A needs-ICTD strategy alignment framework foundation for the measurement of ICTD impact ». Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1011116.
Texte intégralBrodén, Veronica. « An investigation into the connections between new ICTs, universities, and poverty reduction. : A comparative study of SIDA-SAREC ICT projects at universities in Tanzania and Nicaragua ». Thesis, Linköpings universitet, Tema teknik och social förändring, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-65994.
Texte intégralHutchinson, Kelly Anne, et kellyhutchinson@gmail com. « Mapping the dynamics of social enterprise and ICTs in Cambodia : a study of perception, use and benefit of ICT in development of the social enterprise space ». RMIT University. Business Information Technology, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080213.144134.
Texte intégralGacic, Azra. « Bosnienkriget och ICTY : -tidens rättvisa ? » Thesis, Örebro University, Department of Behavioural, Social and Legal Sciences, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7113.
Texte intégralau, J. Green@murdoch edu, et Joanne Helen Green. « ICTs : empowering Western Australian women ? » Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20071114.114223.
Texte intégralMENDONÇA, Thaiane Alves. « ATLAS LINGUÍSTICO DE ICATU (ALinI) ». Universidade Federal do Maranhão, 2017. http://tedebc.ufma.br:8080/jspui/handle/tede/1613.
Texte intégralMade available in DSpace on 2017-06-13T13:29:03Z (GMT). No. of bitstreams: 1 Thaiane Alves.pdf: 24241954 bytes, checksum: ebb2bd7eb5d73f76974759f72768d042 (MD5) Previous issue date: 2017-04-20
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El Atlas Lingüístico de Icatu tiene el objetivo de identicar y mapear las variaciones léxicas encontradas en esa localidad para ampliar el conocimiento del portugués hablado en Brasil y, consecuentemente, en Maranhão, además de ofrecer subsidios para las investigaciones en el área del lenguaje. Los presupuestos teórico metodológicos de la Dialectología y de la Geolingüística orientan el análisis de este trabajo, por medio de autores como Brandão, Coseriu, Ferreira y Cardoso, Isquerdo, Thun . El corpus de esta investigación es constituido de las respuestas obtenidas por medio de la aplicación del Cuestionario Semántico Lexical (QSL), elaborado por el Proyecto Atlas Lingüístico del Brasil (ALiB) y adaptado por el Proyecto Atlas Lingüístico del Maranhão. El cuestionario contiene 227 cuestiones que están distribuidas en 14 áreas semánticas: accidentes geográficos; fenómenos atmosféricos; astros y tiempo; actividades agropastoriles; fauna; cuerpo humano; ciclos de la vida; convivio y comportamiento social; religión y creencias; juegos y diversiones infantiles; espacios y habitaciones; alimentación y cocina; vestuario y accesorios; vida urbana. Se aplicó a 24 informantes en cuatro puntos de investigación, Icatu (sede), Itatuaba, Itapera, Anajatuba, con seis informantes en cada punto, distribuidos igualmente en tres fanjas etarias (franja etaria I - 18 a 30 años, franja etaria II - 50 a 65 años y franja etaria III - 70 años o más), en dos sexos (masculino y femenino). Además de esos criterios, se seleccionó el informante segundo el grado de escolaridad, naturalidad y ocupación o profesión. Basado en los datos obtenidos se elaboraron 227 cartas semántico léxicas en las que se presenta la variación lexical de los elementos investigados en el QSL, con el fin de registrar la memoria lingüística de esa comunidad. Los datos demuestran la riqueza y la gran diversidad del portugués hablado en la localidad. Como ejemplo tenemos las lexías chupa-água, aurinus, barreiro y caiporal, que corresponden, respectivamente, a los términos arco-íris, estrela d’alva, joão de barro y cigarro de palha, es necesario decir que esos términos no aparecieron en las encuestas realizadas por el Proyecto ALiMA en otras localidades de la Provincia de Maranhão.
O Atlas Linguístico de Icatu tem o objetivo de identificar e mapear as variações lexicais encontradas nessa localidade para ampliar o conhecimento do português falado no Brasil e, consequentemente, no Maranhão, além de oferecer subsídios para as pesquisas na área da linguagem. Os pressupostos teóricos-metodológicos da Dialetologia e da Geolinguística orientam a elaboração deste trabalho, através de autores como Brandão, Coseriu, Ferreira e Cardoso, Isquerdo, Thun,. O corpus desta pesquisa é constituído das respostas obtidas por meio da aplicação do Questionário Semântico-Lexical (QSL), elaborado pelo Projeto Atlas Linguístico do Brasil (ALiB) e adaptado pelo Projeto Atlas Linguístico do Maranhão (ALiMA). O questionário contém 227 questões que estão distribuídas em 14 áreas semânticas: acidentes geográficos; fenômenos atmosféricos; astros e tempo; atividades agropastoris; fauna; corpo humano; ciclos da vida; convívio e comportamento social; religião e crenças; jogos e diversões infantis; espaços e habitação; alimentação e cozinha; vestuário e acessórios; vida urbana. Foi aplicado a 24 informantes em quatro pontos de inquéritos, Icatu (sede), Itatuaba, Itapera e Anajatuba, sendo seis informantes em cada ponto, distribuídos igualmente em três faixas etárias (faixa etária I – 18 a 30 anos, faixa etária II – 50 a 65 anos e faixa etária III – 70 anos ou mais), em dois sexos (masculino e feminino). Além desses critérios, o informante foi selecionado segundo grau de escolaridade, naturalidade e ocupação ou profissão. Com base nos dados obtidos foram elaboradas 227 cartas semântico-lexicais em que se apresenta a variação lexical dos itens investigados no QSL, a fim de registrar a memória linguística dessa comunidade. Os dados demonstram a riqueza e a grande diversidade do português falado na localidade. Tomamos como exemplos as variantes lexicais chupa-água, aurinus, barreiro e caiporal, que correspondem, respectivamente, aos termos arco-íris, estrela d’alva, joão de barro e cigarro de palha, cabe ressaltar que esses termos não apareceram nos inquéritos realizados pelo Projeto ALiMA em outras localidades do Estado do Maranhão.
Rose, Angela Gillian. « ICTs in Education in Africa ». Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-21849.
Texte intégralGreen, Joanne Helen. « ICTs : empowering Western Australian women ? » Thesis, Green, Joanne Helen (2005) ICTs : empowering Western Australian women ? PhD thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/87/.
Texte intégralGreen, Joanne Helen. « ICTs : empowering Western Australian women ? / ». Green, Joanne Helen (2005) ICTs : empowering Western Australian women ? PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/87/.
Texte intégralPérez, de la Ossa Herrero Natalia. « Código Ictus : Medidas para mejorar la calidad y efectividad en la atención precoz del ictus ». Doctoral thesis, Universitat Autònoma de Barcelona, 2012. http://hdl.handle.net/10803/117329.
Texte intégralTime is an important factor in the care of acute stroke patients, given the narrow therapeutic window of revascularization therapies. Moreover, the sooner the treatment is given, the higher the clinical benefit. Implementation of Stroke Code (SC) systems, coordinated between hospitals and EMS, reduces the time to treatment and double the rate of thrombolytic therapy. The main objective of this thesis is to detect SC circuits that allow greater effectiveness of the system. We analyzed 1901 patients in which SC was activated in the region of Barcelonès Nord i Maresme during 7 years. Results show that specialized attention at the stroke center was delayed for 80 minutes and thrombolytic therapy for 40 minutes in patients in whom the first level of care was provided at community hospitals compared with the direct transfer via EMS into the stroke center. Moreover, EMS SC activation allowed a higher rate of thrombolytic therapy (50% vs. 21%) and increased the likelihood of good outcome at three months with an OR 2.71 after adjusting for stroke severity and for other prognostic factors. In addition, pre-notification to the stroke center allowed a 15 minutes reduction on the door-to-needle time in comparison to SC activation at the emergency department of the stroke center in patients who come through their own means or without pre-notification. Accordingly with the second objective, these results were validated in 1326 patients treated with tPAev in Catalonia during 2 years. Patients who arrived to the stroke center transferred directly by EMS received tPAev 40 minutes earlier compared with patients transferred from a community hospital and 18 minutes compared with those who came by their own means. Time from symptoms onset to tPAev was independently associated with clinical outcome at 3 months. The third objective was to develop and validate in-the-field a simple pre-hospital stroke scale to detect patients with large-vessel arterial occlusion. The scale RACE (5 items) was designed based on the NIHSS scale items with a higher predictive value of large vessel occlusion on a retrospective cohort of 654 acute stroke admitted to our acute stroke unit. During 18 months, paramedics filled the RACE scale in 263 patients transferred via SC. RACE showed a strong correlation with NIHSS (r=0.81) and a high predictive value for arterial occlusion (ROC curve: AUC 0.81). The best predictive value of RACE was established as ≥ 4; this cut-off value showed sensitivity 0.86, specificity 0.63, positive predictive value 0.53, negative predictive value 0.90 and overall accuracy 0.70 for detecting large vessel occlusion. The scale RACE is a simple clinical tool to be used by paramedics at pre-hospital setting that can be useful to detect acute stroke patients who should be transferred to a Comprehensive Stroke Center for endovascular treatment. Results derived from this study reinforce the importance of prioritizing the SC activation via EMS, since it allows an earlier access to revascularization therapies and a greater clinical benefit of patients with acute stroke. Moreover, EMS transfer allows the possibility to perform a pre-hospital clinical evaluation to decide the most appropriate destination of acute stroke patients. Having into account that in Catalonia only 60% of acute stroke patients alert EMS, or even a smaller percentage in certain rural areas, these results can be useful to guide the implementation of improvement measures addressed to different levels of the healthcare chain.
Costello, Pat. « Towards a model of ICT adoption for the ICT Cluster ». Thesis, University of Wolverhampton, 2009. http://hdl.handle.net/2436/88535.
Texte intégralŠebesta, Michal. « Management of IS/ICT with focus on ICT services outsourcing ». Doctoral thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-261945.
Texte intégralДегтярьова, Ірина Борисівна, Ирина Борисовна Дегтярева et Iryna Borysivna Dehtiarova. « Formulating ict strategies ». Thesis, Видавництво СумДУ, 2006. http://essuir.sumdu.edu.ua/handle/123456789/21537.
Texte intégralBlecher, Jan. « Benchmarking v ICT ». Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-15461.
Texte intégralGiada, Sara <1995>. « ICT e turismo ». Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/18176.
Texte intégralCastro, Márcio Bastos. « NUMA-ICTM : uma versão paralela do ICTM explorando estratégias de alocação de memória para máquinas NUMA ». Pontifícia Universidade Católica do Rio Grande do Sul, 2009. http://hdl.handle.net/10923/1548.
Texte intégralIn Geophysics, the appropriate subdivision of a region into segments is extremely important. ICTM (Interval Categorizer Tesselation Model) is an application that categorizes geographic regions using information extracted from satellite images. The categorization of large regions is a computational intensive problem, what justifies the proposal and development of parallel solutions in order to improve its applicability. Recent advances in multiprocessor architectures lead to the emergence of NUMA (Non-Uniform Memory Access) machines, which combine the efficiency and scalability of MPP (Massively Parallel Processing) machines with the programming facility of the SMP (Symmetric Multiprocessors) machines. In this work, NUMA-ICTM is presented: a parallel solution of ICTM for NUMA machines exploiting memory placement strategies. First, ICTM is parallelized using only OpenMP. After, the OpenMP solution is improved using the MAI (Memory Affinity Interface) library, which allows a control of memory allocation in NUMA machines. The results show that the optimization of memory allocation leads to significant performance gains over the pure OpenMP parallel solution.
Na Geofísica, a subdivisão apropriada de uma região em segmentos é extremamente importante. O ICTM (Interval Categorizer Tesselation Model) é uma aplicação capaz de categorizar regiões geográficas utilizando informações extraídas de imagens de satélite. O processo de categorização de grandes regiões é considerado um problema computacionalmente intensivo, o que justifica a proposta e desenvolvimento de soluções paralelas com intuito de aumentar sua aplicabilidade. Recentes avanços em arquiteturas multiprocessadas caminham em direção a arquiteturas do tipo NUMA (Non-uniform Memory Access), as quais combinam a eficiência e escalabilidade das máquinas MPP (Massively Parallel Processing) com a facilidade de programação das máquinas SMP (Symmetric Multiprocessors). Neste trabalho, é apresentada a NUMA-ICTM: uma solução paralela do ICTM para máquinas NUMA explorando estratégias de alocação de memória. Primeiramente, o ICTM é paralelizado utilizando-se somente OpenMP. Posteriormente, esta solução é otimizada utilizando-se a interfade MAI (Memory Affinity Interface), a qual proporciona um melhor controle sobre a alocação de dados em memória em máquinas NUMA. Os resultados mostram que esta otimização permite importantes ganhos de desempenho sobre a solução paralela que utiliza somente OpenMP.
ESPOSTO, ELISABETTA. « Disuguaglianze di salute nel percorso ictus ». Doctoral thesis, Università Politecnica delle Marche, 2013. http://hdl.handle.net/11566/242564.
Texte intégralBACKGROUND: Level of health and life expectancy are closely related to the social position of patients. AIM: this doctoral work want to describe and analyze both characteristics and size of acute stroke event in the Marches during 2010 and 2011 and in particular for the Azienda Sanitaria Unica Regionale Area Vasta 2, and the social health inequalities in a sample of the population affected by stroke to make a positive contribution to scientific evidence available in this field. METHODS: for the first aim were used all data of Hospital Discharge Data (SDO) of Marches Region for the years 2010 and 2011. In the second part of the thesis was analyzed a sample of population affected by acute stroke selected through a disease code C0404, corresponding to stroke, from data collected from Dispatch of the Centrale Operativa 118 Ancona during a period of six months: from 15 November 2010 to 15 May 2011. To the database were added data related to individual income. RESULTS: in the 2011 the total number of acute stroke in the Marches was n. 3.895 (excluding outside region patients). Due to population in the Marches in the 2011 (census) of 1.565.335 inhabitants, there is a stroke incidence of 2.49 x 1000 inhabitants (3.895/1.565.335). The Area Vasta 2 has an incidence of 2,53 x 1000 inhabitants (1.251/494.522). The sample selected for the analysis of the Stroke Care Pathways consists of 195 units. Cases of death are more frequent among women (48,2% vs 30,1%) and they increase with age of patient. They are also related to individual income and to time of arrival in hospital. The logistic regression model confirms these data. In particular the risk of death increase of 5% for every more year of age (OR=1,05; [CI: 1,00 – 1,09]; p=0,032) and women are more at risk(OR=2,39; [CI: 1,14 – 4,99]; p=0,021). As for individual income, having an income greater than 7.534 euro is a protective factor according to the exitus, in particular people of second and third group are significantly less at risk of death, respectively (OR=0,26; [CI: 0,12 – 0,59]; p=0,001) e (OR=0,30; [CI: 0,10 – 0,94]; p=0,039). As for the arrival hospital, compared to AOU Ospedali Riuniti di Ancona, the other hospitals have a greater risk of death, although this result is significant only for the INRCA and Senigallia respectively (OR=4,65; [CI: 1,08 – 20,11]; p=0,004) and (OR=9,01; [CI: 1,68 – 48,22]; p=0,010), in the first case it was explained by the average old age of patients. CONCLUSION: all data show a strict relation between a low income bracket and death in the stroke care. The importance of strengthen the Stroke Care Pathways guarantee more effective care. All efforts of policy maker should aim to the integrated policies with social field and support to families, trying to compensate distributive differences and strengthen social tissue.
Dvořák, Jan. « Procesy IS/ICT a jejich mapování ke standardům v oblasti IS/ICT ». Master's thesis, Vysoká škola ekonomická v Praze, 2011. http://www.nusl.cz/ntk/nusl-124773.
Texte intégralWaller, Lloyd George. « ICTs for whose development ? : a critical analysis of the discourses surrounding an ICT for development initiative for a group of microenterprise entrepreneurs operating in the Jamaican tourism industry : towards the development of methodologies and analytical tools for understanding and explaining the ICT for development phenomenon / ». The University of Waikato, 2006. http://hdl.handle.net/10289/2628.
Texte intégralCougo, França Bernardo. « Design and Optimization of InterCell Transformers for Parallel MultiCell Converters ». Thesis, Toulouse, INPT, 2010. http://www.theses.fr/2010INPT0057/document.
Texte intégralIn recent years, the interest for parallel multicell converters has grown, which is partially due to the possibility of coupling the inductors used to connect the different commutation cells together. Coupling the inductors to form an InterCell Transformer (ICT) does not usually modify the output current, but it reduces the current ripple in the windings and the flux swing in some regions of the core. It can be shown that this brings a reduction of copper and core losses in the magnetic component. The reduction of the phase current ripple also reduces the difference between turn on and turn off current in the switches, which brings a reduction of switching losses for devices generating more losses at turn off than at turn on. The design of an ICT is not that different from any other magnetic component but it is very specific and inherent features must be taken into account. Taking full benefit of the potential advantages of ICTs requires the development of special tools and methods which are the focus of the study. We show how to design ICTs considering several topologies and different methods, from the most precise and time-consuming to the less accurate but more quickly calculated. The explanation of the ICT design is divided in four main parts: Copper Losses, Core Losses, Flux Density Saturation and Thermal Aspects. Further attention is given to high frequency copper losses since complex phenomena such as skin and proximity effects highly influence the ICT design. Based on Finite Element Method simulations, smart practices are suggested to reduce high and low frequency copper losses, not only in ICTs but also in inductors and transformers. Simple tables are developed to help transformer designers to identify the best configuration of conductors inside a given core window, depending on the current waveform and frequency, number of turns and geometrical parameters. Optimization routines to reduce the ICT total mass, volume, losses or cost are developed and multidimensional interpolation of pre-simulated values of AC resistance and leakage inductance is used to speed up the optimization routine. Comparison of ICT designs with regard to core and conductor material, number of cells and switching frequency is performed. Comparison with regular inductors is also made in order to verify the benefits of this kind of magnetic component. Multilevel converter control aspects applied to three- hase systems is also investigated in terms of the ICT flux. Zero sequence signals, specific for a PWM strategy and converter/load topology, are created in order to minimize the flux in ICTs and consequently reduce even further the mass and size of these components. Comparison between several PWM methods are performed and experimentally verified
Berg, Agneta. « Glutamine to ICU patients / ». Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-423-5/.
Texte intégralO'Neill, Ray. « ICT as political action ». Thesis, University of South Wales, 2008. https://pure.southwales.ac.uk/en/studentthesis/ict-as-political-action(0e4deb95-6163-4b71-9061-a25956f766ed).html.
Texte intégralBelokur, Dmitriy. « Sociální sítě a ICT ». Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-12421.
Texte intégralNaiman, Michal. « Virtualizace v IS/ICT ». Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-15505.
Texte intégralKashapov, Artur. « Analýza trhu IS/ICT ». Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-165116.
Texte intégralJelínek, Martin. « Technologická integrace ICT služeb ». Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-193574.
Texte intégralPilík, Tomáš. « Organizační kultura ICT společností ». Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-198087.
Texte intégralWeinsteinová, Adéla. « Negativní aspekty nasazování ICT ». Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-199727.
Texte intégralŠilhavá, Kateřina. « Marketingová komunikace ICT integrátora ». Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359789.
Texte intégralGoode, Fay. « Noise in the ICU ». ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3525.
Texte intégralHelešic, Igor. « Návrh ICT strategie podniku ». Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2009. http://www.nusl.cz/ntk/nusl-222182.
Texte intégralVendl, Jan. « Management ICT střední školy ». Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2016. http://www.nusl.cz/ntk/nusl-234698.
Texte intégralDI, FABIO SILVIO. « Essays on ICT diffusion ». Doctoral thesis, Università Politecnica delle Marche, 2018. http://hdl.handle.net/11566/253659.
Texte intégralThis thesis introduces a class of epidemic diffusion models specifically tailored to the description and analysis of ICT technologies, by defining a dynamic potential market that depends on the network size of the number of individuals who have already adopted. Compared to traditional “stand alone” products, ICT technologies have peculiar characteristics and different adoption behaviours that can be explained by network effects and externalities. After an overview of the state of the art of the literature on the diffusion of innovations and on networks (chapter 1), the theoretical work is presented (chapter 2). Here, we carry out a systematic functional study leading to the construction of a class of new models, to their parameterization and analysis in comparative statics, and finally simulation. The basic Bass model, which assumes a fixed potential market, is taken as a reference for comparisons, beside being the backbone of our class of models. From the simulations, it emerges that our class of models is able to describe the network effects (and externalities) and their role in shaping the diffusion of such technologies. In chapter 3, we test the capability of this class of models to explain empirically, with market data, the historical ICT diffusion paths, trying to derive useful implications for the policy-maker (for example, in the realm of contemporary digital agendas). This chapter features the NLS econometric estimation of the previous models, taking as a reference the real diffusion paths of broadband technologies in selected EU countries: in particular, we focus on the ITU time series of fixed broadband subscriptions of the "five big" European countries. The econometric estimates confirm that our class of models provides an original analytical and empirical instrument for capturing and stylizing the network phenomena that dominate the diffusion paths of the main telecommunications and media markets, such as fixed broadband. As such, it also enables a series of future policy evaluation exercises.
Mantovanelli, Thais. « Crianças invisíveis da Reserva Indígena Icatu/SP ». Universidade Federal de São Carlos, 2011. https://repositorio.ufscar.br/handle/ufscar/218.
Texte intégralFinanciadora de Estudos e Projetos
Como as crianças Kaingang do Icatu SP vivenciam os espaços da aldeia? A proposta desta dissertação é contribuir para as discussões sobre as relações sociais das crianças indígenas a partir da experiência etnográfica entre os Kaingang da aldeia Icatu SP. O recorte dessa temática surgiu de meu descontentamento inicial com relação às atividades das crianças no cotidiano da Reserva. Contrário do que eu esperava encontrar, as crianças pareciam-me invisíveis. Assim, percebi que elas passavam a maior parte do tempo dentro dos quintais, nas casas de suas avós maternas. Essa invisibilidade levou-me a refletir sobre os modos como poderia realizar minha pesquisa. A saída encontrada em campo, indicada pelas mulheres, foi conversar com mães, tias e avós das casas que eu frequentava. Essa configuração levou à necessidade de destacar a não transitoriedade das crianças da aldeia Icatu SP como uma forma específica do tipo de relação entre elas e suas casas e promover uma discussão sobre a impossibilidade da aplicação de conceitos universais em pesquisas que tem a criança como destaque.
Khudair, Ahmad A. « Health sciences libraries : information services and ICTs ». Thesis, City University London, 2005. http://openaccess.city.ac.uk/11881/.
Texte intégralJebari, Salha. « The inelastic Cooper pair tunneling amplifier (ICTA) ». Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAY036/document.
Texte intégralJosephson parametric amplifiers (JPA), have proven to be an indispensable tool for awide range of experiments on quantum devices in the microwave frequency regime, becausethey provide the lowest possible noise. However, JPAs remain much more difficult to use andoptimize than conventional microwave amplifiers. Recent experiments with superconductingcircuits consisting of a DC voltage-biased Josephson junction in series with a resonator,showed that a tunneling Cooper pair can emit one or several photons with a total energyof 2e times the applied voltage. In this thesis we show that such q circuit can be used toimplement a new type of phase preserving microwave amplifier, which we call InelasticCooper pair Tunneling Amplifier (ICTA). It is powered by a simple DC bias and offers nearquantum-limited noise performance.We start this work by presenting a brief and simple picture of the basic ICTA operatingprinciples. In analogy with the quantum theory of JPAs, we calculate the performances ofthis amplifier such as the gain, bandwidth and noise. Then, we present the first experimentalproof that amplification close to the quantum limit is possible without microwave drive inan extremely simple setup. These measurements are made on a first generation of samplesbased on aluminium junctions. According to our theoretical and experimental results, wehave designed microwave circuits presenting specific frequency-dependent impedances tothe junction in order to optimize the performances of our amplifier. This second generationof ICTA samples is fabricated from niobium nitride and provide significantly lower noiseand higher gain.We expect that once fully optimized, such an amplifier, powered by simple DC voltagescould then make measuring microwave signals at the single photon level much easier andallow to deploy many amplifiers on a chip. It could therefore be an important ingredient forqubit readout in large-scale quantum processors
Kotter, Elmar. « Ictus amnésique : étude clinique de 50 cas ». Montpellier 1, 1993. http://www.theses.fr/1993MON11011.
Texte intégralNoël, Audrey. « Ictus amnésique idiopathique : neuropsychologie, neuroimagerie et psychopathologie ». Caen, 2007. http://www.theses.fr/2007CAEN1493.
Texte intégralAuzinger-Hotzel, Kathrin Michaela. « Information and Communication Technologies (ICTs) and Citizenship ». ScholarWorks, 2017. https://scholarworks.waldenu.edu/dissertations/3334.
Texte intégralCalitz, André Paul. « A model for the alignment of ICT education with business ICT skills requirements ». Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1418.
Texte intégralSweeney, Jennifer. « Adherence to the ICU Liberation ABCDEF Bundle Improves Patient Outcomes in the ICU ». ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5041.
Texte intégralHasan, Md Zahid. « Social Equity and Integrity through ICT : A Critical DiscourseAnalysis of ICT Policies in Bangladesh ». Thesis, Uppsala universitet, Institutionen för informatik och media, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169139.
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