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Gounder, Mrinal M., Alona Zer, William D. Tap, Samer Salah, Mark A. Dickson, Abha A. Gupta, Mary Louise Keohan et al. « Phase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma ». Journal of Clinical Oncology 34, no 26 (10 septembre 2016) : 3166–74. http://dx.doi.org/10.1200/jco.2016.67.6346.
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Purpose We evaluated the pharmacokinetics (PKs), pharmacodynamics, safety, and efficacy of selinexor, an oral selective inhibitor of nuclear export compound, in patients with advanced soft tissue or bone sarcoma with progressive disease. Patients and Methods Fifty-four patients were treated with oral selinexor twice per week (on days 1 and 3) at one of three doses (30 mg/m2, 50 mg/m2, or flat dose of 60 mg) either continuously or on a schedule of 3 weeks on, 1 week off. PK analysis was performed under fasting and fed states (low v high fat content) and using various formulations of selinexor (tablet, capsule, or suspension). Tumor biopsies before and during treatment were evaluated for pharmacodynamic changes. Results The most commonly reported drug-related adverse events (grade 1 or 2) were nausea, vomiting, anorexia, and fatigue, which were well managed with supportive care. Commonly reported grade 3 or 4 toxicities were fatigue, thrombocytopenia, anemia, lymphopenia, and leukopenia. Selinexor was significantly better tolerated when administered as a flat dose on an intermittent schedule. PK analysis of selinexor revealed a clinically insignificant increase (approximately 15% to 20%) in drug exposure when taken with food. Immunohistochemical analysis of paired tumor biopsies revealed increased nuclear accumulation of tumor suppressor proteins, decreased cell proliferation, increased apoptosis, and stromal deposition. Of the 52 patients evaluable for response, none experienced an objective response by RECIST (version 1.1); however, 17 (33%) showed durable (≥ 4 months) stable disease, including seven (47%) of 15 evaluable patients with dedifferentiated liposarcoma. Conclusion Selinexor was well tolerated at a 60-mg flat dose on a 3-weeks-on, 1-week-off schedule. There was no clinically meaningful impact of food on PKs. Preliminary evidence of anticancer activity in sarcoma was demonstrated.
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Kustati, Martin. « An Analysis of Code-Mixing and Code-Switching in EFL Teaching of Cross Cultural Communication Context ». Al-Ta lim Journal 21, no 3 (19 novembre 2014) : 174–82. http://dx.doi.org/10.15548/jt.v21i3.101.
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The objective of the paper is to determine types of code-mixing and code-switching made by teachers and students in EFL cross cultural communication class and to identify reasons for the emergence of code-switching and mixing in the classroom. The data was obtained through observation and in-depth interviews of the second year students of undergraduate program of English in Tarbiyah Faculty, IAIN IB Padang. The finding showed that tag-switching, intra-sentential, inter-sentential, and intra-word were commonly used by EFL teachers and students in classroom. It was also found that the teachers used code-mixing and switching in the process of clarifying certain issues to make them more comprehensible to students. Teachers also do these kinds of switching during their attempt to promote relationship with students, to switch the topic, and to persuade or motivate students to be more engaged in learning English. Meanwhile, the students mix and switch their language to overcome their lack of knowledge of English. It is expected that this study provided empirical evidence to advise on their optimal uses in EFL teaching of State Institute for Islamic Studies.Copyright © 2014 by Al-Ta'lim All right reserved
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Mat Razali, Nurhani, Siti Norvahida Hisham, Ilakiya Sharanee Kumar, Rohit Nandan Shukla, Melvin Lee, Mohd Faizal Abu Bakar et Kalaivani Nadarajah. « Comparative Genomics : Insights on the Pathogenicity and Lifestyle of Rhizoctonia solani ». International Journal of Molecular Sciences 22, no 4 (22 février 2021) : 2183. http://dx.doi.org/10.3390/ijms22042183.
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Proper management of agricultural disease is important to ensure sustainable food security. Staple food crops like rice, wheat, cereals, and other cash crops hold great export value for countries. Ensuring proper supply is critical; hence any biotic or abiotic factors contributing to the shortfall in yield of these crops should be alleviated. Rhizoctonia solani is a major biotic factor that results in yield losses in many agriculturally important crops. This paper focuses on genome informatics of our Malaysian Draft R. solani AG1-IA, and the comparative genomics (inter- and intra- AG) with four AGs including China AG1-IA (AG1-IA_KB317705.1), AG1-IB, AG3, and AG8. The genomic content of repeat elements, transposable elements (TEs), syntenic genomic blocks, functions of protein-coding genes as well as core orthologous genic information that underlies R. solani’s pathogenicity strategy were investigated. Our analyses show that all studied AGs have low content and varying profiles of TEs. All AGs were dominant for Class I TE, much like other basidiomycete pathogens. All AGs demonstrate dominance in Glycoside Hydrolase protein-coding gene assignments suggesting its importance in infiltration and infection of host. Our profiling also provides a basis for further investigation on lack of correlation observed between number of pathogenicity and enzyme-related genes with host range. Despite being grouped within the same AG with China AG1-IA, our Draft AG1-IA exhibits differences in terms of protein-coding gene proportions and classifications. This implies that strains from similar AG do not necessarily have to retain similar proportions and classification of TE but must have the necessary arsenal to enable successful infiltration and colonization of host. In a larger perspective, all the studied AGs essentially share core genes that are generally involved in adhesion, penetration, and host colonization. However, the different infiltration strategies will depend on the level of host resilience where this is clearly exhibited by the gene sets encoded for the process of infiltration, infection, and protection from host.
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Masalha, Mahmud, Ilya Borovok, Rachel Schreiber, Yair Aharonowitz et Gerald Cohen. « Analysis of Transcription of theStaphylococcus aureus Aerobic Class Ib and Anaerobic Class III Ribonucleotide Reductase Genes in Response to Oxygen ». Journal of Bacteriology 183, no 24 (15 décembre 2001) : 7260–72. http://dx.doi.org/10.1128/jb.183.24.7260-7272.2001.
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ABSTRACT Staphylococcus aureus is a gram-positive facultative aerobe that can grow in the absence of oxygen by fermentation or by using an alternative electron acceptor. To investigate the mechanism by which S. aureus is able to adapt to changes in oxygen concentration, we analyzed the transcriptional regulation of genes that encode the aerobic class Ib and anaerobic class III ribonucleotide reductase (RNR) systems that are responsible for the synthesis of deoxyribonucleotides needed for DNA synthesis. The S. aureus class Ib RNR nrdIEF and class III RNRnrdDG genes and their regulatory regions were cloned and sequenced. Inactivation of the nrdDG genes showed that the class III RNR is essential for anaerobic growth. Inhibition of aerobic growth by hydroxyurea showed that the class Ib RNR is an oxygen-dependent enzyme. Northern blot analysis and primer extension analysis demonstrated that transcription of class IIInrdDG genes is regulated by oxygen concentration and was at least 10-fold higher under anaerobic than under aerobic conditions. In contrast, no significant effect of oxygen concentration was found on the transcription of class Ib nrdIEF genes. Disruption or deletion of S. aureus nrdDG genes caused up to a fivefold increase in nrdDG and nrdIEFtranscription under anaerobic conditions but not under aerobic conditions. Similarly, hydroxyurea, an inhibitor of the class I RNRs, resulted in increased transcription of class Ib and class III RNR genes under aerobic conditions. These findings establish that transcription of class Ib and class III RNR genes is upregulated under conditions that cause the depletion of deoxyribonucleotide. Promoter analysis of class Ib and class III RNR operons identified several inverted-repeat elements that may account for the transcriptional response of thenrdIEF and nrdDG genes to oxygen.
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REHMAN, MUHAMMAD ATTIQ, HEIDI REMPEL, CATHERINE D. CARRILLO, KIM ZIEBELL, KEVIN ALLEN, AMEE R. MANGES, EDWARD TOPP et MOUSSA S. DIARRA. « Virulence Genotype and Phenotype of Multiple Antimicrobial-Resistant Escherichia coli Isolates from Broilers Assessed from a “One-Health” Perspective ». Journal of Food Protection 85, no 2 (11 novembre 2021) : 336–54. http://dx.doi.org/10.4315/jfp-21-273.
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ABSTRACT Extraintestinal pathogenic Escherichia coli (ExPEC) include several serotypes that have been associated with colibacillosis in poultry and with urinary tract infections (UTIs) and newborn meningitis in humans. In this study, 57 antimicrobial-resistant E. coli from apparently healthy broiler chickens were characterized for their health and safety risks. These isolates belonged to 12 serotypes, and isolates of the same serotype were clonal based on single nucleotide variant analysis. Most of the isolates harbored plasmids; IncC and IncFIA were frequently detected. The majority of the resistant isolates harbored plasmid-mediated resistance genes, including aph(3″)-Ib, aph(6)-Id, blaCMY-2, floR, sul1, sul2, tet(A), and tet(B), in agreement with their resistant phenotypes. The class 1 integron was detected in all E. coli serotypes except O124:H25 and O7:H6. Of the 57 broiler E. coli isolates, 27 were avian pathogenic, among which 18 were also uropathogenic E. coli and the remainder were other ExPEC. The two isolates of serotype O161:H4 (ST117) were genetically related to the control avian pathogenic strains and a clinical isolate associated with UTIs. A strain of serotype O159:H45 (ST101) also was closely related to a UTI isolate. The detected virulence factors included adhesins, invasins, siderophores, type III secretion systems, and toxins in combination with other virulence determinants. A broiler isolate of serotype O7:H18 (ST38) carried the ibeA gene encoding a protein involved in invasion of brain endothelium on a 102-kbp genetic island. This isolate moderately adhered and invaded Caco-2 cells and induced mortality (42.5%) in a day-old-chick infection model. The results of this study suggest that multiple antimicrobial-resistant E. coli isolates recovered from apparent healthy broilers can be pathogenic and act as reservoirs for antimicrobial resistance genes, highlighting the necessity of their assessment in a “One-Heath” context. HIGHLIGHTS
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Weekes, Colin D., David Tsai Ting, Aparna Raj Parikh, Stacie Ittershagen, Claire Fabre, Viviana Cremasco, David Ruddy et al. « Phase Ib study testing neoadjuvant transforming growth factor (TGF)-β antibody, NIS793, plus 5-fluorouracil, irinotecan, and oxaliplatin chemotherapy (FOLFIRINOX) in patients (pts) with borderline resectable (BR)/locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). » Journal of Clinical Oncology 41, no 4_suppl (1 février 2023) : TPS762. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.tps762.
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TPS762 Background: Overcoming resistance to chemotherapy and immune checkpoint inhibitors remains an unmet need for PDAC. In this context, TGF-β plays a key role in PDAC by promoting the activation of fibroblasts and extracellular matrix deposition, facilitating epithelial-to-mesenchymal transition, immune evasion, and resistance to chemotherapy. Combination of FOLFIRINOX with losartan, an indirect TGF-β inhibitor with antifibrotic properties, has shown an increased R0 resection rate in pts with BR/LA PDAC, providing the rationale to explore the combination of other TGF-β targeting agents with FOLFIRINOX in the neoadjuvant setting (PMID: 34884782; PMID: 31145418). NIS793 is a first-in-class monoclonal antibody that directly binds TGF-β and reduces intratumoral fibrosis in preclinical models (PMID: 33298926). NIS793 also has an acceptable safety profile and preliminary clinical activity. This study investigates whether NIS793 modulation of the tumor fibrotic network improves clinical outcomes of FOLFIRINOX neoadjuvant therapy in BR/LA PDAC. Our aim is to demonstrate how TGF-β inhibition and stroma remodeling contribute to clinical outcomes. Methods: This is a single institution, open label, 2-part, 2-arm, non-comparator, Phase Ib study (NCT05417386) of FOLFIRINOX + NIS793 as neoadjuvant therapy for pts with untreated BR/LA PDAC. Eligible pts are adults with measurable disease, adequate organ and bone marrow function, and ECOG PS ≤1. In Part 1 (safety run-in), 6-18 pts with histologically confirmed untreated metastatic PDAC receive FOLFIRINOX + NIS793 at different dose levels. Dose escalation is primarily guided by the number of dose-limiting toxicities. Primary objectives are assessing safety, defining the recommended Phase II dose (RP2D), and providing initial evidence of clinical benefit of the combination. In Part 2, pts with untreated BR/LA PDAC are randomized 4:1 and stratified by BR vs LA. Pts in Arm 1 (n=5) receive 8 cycles of FOLFIRINOX followed by chemoradiation therapy (CRT) and surgery. Pts in Arm 2 (n=23) receive 8 cycles of FOLFIRINOX + NIS793 at RP2D followed by CRT + NIS793, surgery, and 12 cycles of adjuvant NIS793. The primary endpoint is R0 resection rate. Secondary endpoints are disease-free survival, progression-free survival, overall survival, and pathologic complete response. The effect of neoadjuvant therapy will be assessed by ferumoxytol-MRI, circulating cell-free DNA dynamics analysis, single-cell RNA sequencing, immunohistochemistry, and digital spatial analysis. Together, these correlative analyses may enable development of a mechanistic model for TGF-β inhibition in PDAC. This study is ongoing. The first pt was treated on Aug 2, 2022. Clinical trial information: NCT05417386 .
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Ploy, Marie-Cécile, François Denis, Patrice Courvalin et Thierry Lambert. « Molecular Characterization of Integrons inAcinetobacter baumannii : Description of a Hybrid Class 2 Integron ». Antimicrobial Agents and Chemotherapy 44, no 10 (1 octobre 2000) : 2684–88. http://dx.doi.org/10.1128/aac.44.10.2684-2688.2000.
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ABSTRACT Twenty Acinetobacter baumannii strains resistant to various antibiotics were analyzed for integron content and sequences of the amplification products. Sixteen clinical isolates had a class 1 integron, 2 contained an additional class 1 or class 2 integron, but no class 3 integron was detected. Thirteen strains had integrons with a single cassette: aac(3)-Ia (9 strains), ant(2")-Ia (2 strains), or aac(6′)-Ib (2 strains); 1 hadaac(6′)-Ib and oxa20cassettes and an unknown gene; and 1 had an integron containingant(2")-Ia and an oxa3cassette truncated by IS6100. The remaining strains harbored class 1 integrons with gene cassettes previously found inEnterobacteriaceae. One integron had a hybrid structure composed of intI2 and the 3′ conserved segment of class 1 integrons. These data indicate that integrons play a major role in multidrug resistance in Acinetobacter.
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Cheroutre, H., M. Kronenberg, K. Brorson, S. W. Hunt, P. Eghtesady, L. Hood et D. A. Nickerson. « Analysis of MHC class I gene expression in adult bone marrow and fetal liver of the BALB/c mouse. » Journal of Immunology 146, no 10 (15 mai 1991) : 3263–72. http://dx.doi.org/10.4049/jimmunol.146.10.3263.
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Abstract The BALB/c mouse has at least 29 class I genes encoded in the Qa, Tla, and Hmt (histocompatibility dependent on a maternally transmitted factor) regions of the MHC. The pattern of expression of these class Ib MHC genes is not well characterized, although some of their products such as the serologically detectable Qa-2 and TL Ag are expressed mainly in lymphoid and hematopoietic tissues. In this study, the expression pattern of BALB/c class I genes has been analyzed in adult bone marrow and fetal liver. cDNA libraries were synthesized from these tissues, and isolated class I cDNA clones were characterized by hybridization with oligonucleotide probes and by nucleotide sequence analysis. Of the 29 total class Ib genes, transcripts of five including Q6d, Q7d, T9c, T10c, and the 37 gene were isolated from the bone marrow cDNA library. Four of these can encode proteins; the sequence of the T10c gene demonstrates it is most likely a pseudogene. A non-overlapping set of three class Ib cDNA clones was obtained from the fetal liver, including T13c, the Thy 19.4 gene, and a previously uncharacterized class I gene provisionally designated as FL 57.2. Although the majority of H-2Dd cDNA clones that were analyzed lack introns, many of the class Ib cDNA clones contain intron sequences. This suggests that the expression of some of these genes may be regulated at the level of RNA splicing. The T13c gene encodes the thymus leukemia Ag in BALB/c mice. We have confirmed that the T13c gene is expressed in fetal liver by flow cytometric analysis of cells stained with anti-TL mAb.
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Nedelkovska, Hristina, et Jacques Robert. « HSP70-mediated antigen-dependent nonclassical MHC class Ib-restricted anti-tumor responses in the frog Xenopus laevis (170.15) ». Journal of Immunology 186, no 1_Supplement (1 avril 2011) : 170.15. http://dx.doi.org/10.4049/jimmunol.186.supp.170.15.
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Abstract The heat shock proteins (hsps) hsp70 are highly conserved molecular chaperones that elicit potent T cell responses against the antigens (Ags) they chaperone in both mammals and Xenopus. We have shown that frogs immunized with hsp70 generate CD8 T cell responses against the Xenopus thymic tumor 15/0 that expresses several nonclassical MHC class Ib genes, but not classical MHC class Ia. Therefore, we hypothesized that hsp70 can prime class Ib-mediated anti-tumor unconventional CD8 T cells in an Ag-dependent manner. To test this, we produced Xenopus recombinant tagged hsp70 proteins (both the cognate hsc73 and the inducible hsp72) from stable 15/0 tumor transfectants. Antigenic peptides can be easily removed from both hsps by ATP treatment. We used a cross-presentation assay to adoptively transfer hsp-pulsed antigen presenting cells and showed that both hsp72 and hsc73-Ag complexes, but not ATP treated Ag-negative hsp70s, elicit class Ib-mediated CD8 T cells responses resulting in protection from 15/0 tumor challenge. From expression studies, we further postulate that these responses involve one or a few class Ib gene products among which XNC10 is the prime candidate due to its lymphoid tissue distribution. To further elucidate the role of class Ib molecules in anti-tumor immunity, we developed a reverse genetic approach combining transgenesis and siRNA technology and obtained F1 Xenopus clones with silenced expression of class Ib in vivo that will be used for further analysis.
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Fiszer, Dorota, Matthias Ulbrecht, Nelson Fernandez, Judith P. Johnson, Elisabeth H. Weiss et Maciej Kurpisz. « Analysis of HLA class Ib gene expression in male gametogenic cells ». European Journal of Immunology 27, no 7 (juillet 1997) : 1691–95. http://dx.doi.org/10.1002/eji.1830270715.
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Leong, Louise Y. W., Anne-France Le Rolle, Edward V. Deverson, Simon J. Powis, Audrey P. Larkins, John T. Vaage, Aasa Stokland et al. « RT1-U : Identification of a Novel, Active, Class Ib Alloantigen of the Rat MHC ». Journal of Immunology 162, no 2 (15 janvier 1999) : 743–52. http://dx.doi.org/10.4049/jimmunol.162.2.743.
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Abstract In common with other mammalian species, the laboratory rat (Rattus norvegicus) expresses MHC class I molecules that have been categorized as either classical (class Ia) or nonclassical (class Ib). This distinction separates the class Ia molecules that play a conventional role in peptide Ag presentation to CD8 T cells from the others, whose function is unconventional or undefined. The class Ia molecules are encoded by the RT1-A region of the rat MHC, while the RT1-C/E/M region encodes up to 60 other class I genes or gene fragments, a number of which are known to be expressed (or to be expressible). Here we report upon novel MHC class Ib genes of the rat that we have expression cloned using new monoclonal alloantibodies and which we term RT1-U. The products detected by these Abs were readily identifiable by two-dimensional analysis of immunoprecipitates and were shown to be distinct from the class Ia products. Cellular studies of these molecules indicate that they function efficiently as targets for cytotoxic killing by appropriately raised polyclonal alloreactive CTL populations. The sequences of these class Ib genes group together in phylogenetic analysis, suggesting a unique locus or family. The combined serological, CTL, and sequence data all indicate that these products are genetically polymorphic.
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Houlihan, J. M., P. A. Biro, H. M. Harper, H. J. Jenkinson et C. H. Holmes. « The human amnion is a site of MHC class Ib expression : evidence for the expression of HLA-E and HLA-G. » Journal of Immunology 154, no 11 (1 juin 1995) : 5665–74. http://dx.doi.org/10.4049/jimmunol.154.11.5665.
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Abstract The expression of HLA class I Ag by term human amnion epithelial cells was investigated. In immunostaining and FACS analysis, mAb to monomorphic class I Ag reacted extensively with amnion cells, whereas polymorphic mAb reactivity was more limited and variable. Further studies were conducted on amnion cell preparations containing negligible contaminants. Northern analysis with use of locus-specific probes demonstrated that amnion expresses two class Ib genes, HLA-E and HLA-G. Radio-immunoprecipitation with use of monomorphic mAb identified two fully glycosylated cell surface class I H chains of 44 and 41 kDa; polymorphic mAbs failed to immunoprecipitate the 41-kDa product, although 44-kDa products, typical of class Ia Ag, were identified in some preparations. Class I H chains were isolated from amnion by affinity chromatography. Microsequencing revealed that the first nine residues of the N-terminus of the 41-kDa product aligned perfectly only with HLA-E. Overall, amnion at term appears to express class Ib Ag with limited class Ia Ag. HLA-G is therefore expressed in two extrafetal epithelia: amnion and trophoblast. Identification of the class Ib protein HLA-E in amnion epithelium may have implications for preterm labor that can be associated with infection of the placental membranes.
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Lowen, L. C., C. J. Aldrich et J. Forman. « Analysis of T cell receptors specific for recognition of class IB antigens. » Journal of Immunology 151, no 11 (1 décembre 1993) : 6155–65. http://dx.doi.org/10.4049/jimmunol.151.11.6155.
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Abstract T cells that recognize a peptide presented by a self-class IA molecule generally use a restricted repertoire of V beta and V alpha receptors. In contrast, alloreactive T cells, which recognize alloantigens that present a wide array of peptides, use a diverse repertoire, particularly in the CDR3 loop. Because the T cell repertoire directed against class IB alloantigens is not known, we examined V-D-J sequences in V beta chains specific for Qa-1 and similar sequences in both V beta and V alpha chains specific for Qa-2. We observed that 14 Qa-1-specific clones use a limited number of V beta segments and 8 of 14 express V beta 8.2 and have a conservation of charged residues in the CDR3 loop, particularly between residues 99 and 101. Thirteen of the 14 clones rearrange to the second J beta cluster and use within this cluster is restricted. Alloreactive anti-Qa-1 T cells can be assigned into three different specificity groups based on a Qa-1 modifying gene, Qdm, as well as Qa-1 epitope expression on Tap-2-deficient RMA-S cells. Receptors from members of each specificity group are more similar in their CDR3 loop to each other than members of the other groups. These data lend support to the Qa-1 class IB Ag presenting a limited number of peptides to T cells or in some manner limiting the development of a diverse alpha beta T cell repertoire. The alpha- and beta-chains from nine alloreactive anti-Qa-2 clones were analyzed. V beta use was limited to use of V beta 7 or a member of the V beta 8 family. Rearrangements were solely to the second J beta cluster. The use of V alpha and J alpha segments were diverse. Although conserved residues or motifs were observed in the CDR3 regions of both the beta- and alpha-chains, the extent of conservation was less than that for anti-Qa-1 receptors. Anti-Qa-2 T cells can be divided into two specificities, Q6 and Q7. No common features were apparent between these groups.
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Gustafson, W. Norman. « Content Analysis in the History Class ». Social Studies 89, no 1 (janvier 1998) : 39–44. http://dx.doi.org/10.1080/00377999809599821.
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Hwang, Mi-young, et Sunun Park. « A Content Analysis of Human Rights Education in IB Global Politics Textbooks ». Journal of Human Rights & ; Law-related Education 15, no 3 (30 décembre 2022) : 21–46. http://dx.doi.org/10.35881/hler.2022.15.3.2.
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Maryono, Geby Devtiana, et Emi Emilia. « An analysis of International Baccalaureate – English Language Curriculum for Middle Year Program ». PAROLE : Journal of Linguistics and Education 12, no 1 (30 avril 2022) : 69–80. http://dx.doi.org/10.14710/parole.v12i1.69-80.
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The IB Curriculum, which was initially founded in Switzerland, is used globally. Many schools in Indonesia also apply this curriculum, and the number keeps growing. This paper will present the results of a study aiming to investigate the ideology, model, and elements of the International Baccalaureate (IB) curriculum, specifically the English (Language Acquisition) curriculum for the Middle Year Program (secondary school). The study has been given shape by the theory of curriculum development. The study employed a case study research design, especially text analysis. The results show that the English IB curriculum applies a learner-cantered ideology with collaborative learning to build students’ communicative skills. It also has been influenced by a deductive model proposed by Tyler. Moreover, the elements also confirm Tyler’s rationale, consisting of objectives, the content, learning activities or learning experiences designed to achieve the objectives various types of assessments and evaluations.
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Ali, Muhammad Haidir, et Ahmad Tarmidzi Lubis. « Analisis Pengungkapan Sukarela pada Bank Umum Syariah di Indonesia ». JURNAL AKUNTANSI DAN KEUANGAN ISLAM 3, no 1 (6 mars 2019) : 5–19. http://dx.doi.org/10.35836/jakis.v3i1.37.
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This study is a descriptive study to assess voluntary disclosure in annual reportsIslamic Banks (iB) with that should be disclosed. Annual reports used in this study isan annual report iB in Indonesia in 2011, 2012, and 2013. This research is relativelynew because no one has done research on voluntary disclosure in Islamic Banks (iB).Therefore, in order to study to obtain maximum results, the coding instructions forvoluntary disclosure must be in accordance with the study conducted by Rr. PuruwitaWardani (2012) entitled "Factors Affecting Voluntary Disclosure area. Analysis toolsare used is the content analysis by collecting words that expressed the count. Theresults showed that during the three-year study period, 2011, 2012, and 2013 therewas an increase in the provision of good disclosure of the number of items disclosedor revealed iB number. But overall tenth iB already provide adequate voluntarydisclosure to reveal the items contained in the variable voluntary disclosure eventhough the iB newly established in 2010.
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Lintang, Luthfiah, Lelya Hilda et Nur Fauziah Siregar. « Perbedaan Hasil Belajar Matematika Menggunakan Model Pembelajaran Make a Match dan Model Pembelajaran Pair Checks ». ARITHMETIC : Academic Journal of Math 3, no 1 (30 décembre 2021) : 47. http://dx.doi.org/10.29240/ja.v3i1.2854.
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This study aims to determine the significant difference between the learning outcomes of mathematics using the model Make a Match learning and Pair Checks learning model on the integer material in class VII MTs IB Silaping. This type of research is a comparative study with experimental methods. The population in this study were students of class VII MTs IB Silaping totaling 92 students. The sample of this research is class VII2 b as the experimental class 1 and class VII1 a as the experimental class 2 with the same number of 16 students. The samples were determined by non-probability sampling. The data collection instrument is a test. The data analysis technique used is the normality test, homogeneity test, and to test the hypothesis with the t-test. The results of this study indicate that: (1) mathematics learning outcomes using the Make a Match learning model with an average value of 86,88; (2) mathematics learning outcomes using the Pair Checks learning model with an average value of 80,56. So it can be concluded that (3) there is a significant difference between the learning outcomes of mathematics using the Make a Match learning model and the Pair Checks learning model on the integer material in class VII MTs IB Silaping. This is in accordance with the calculation of the t-test which is obtained at the significant level is 0,05 and dk = 30 with tcount = 2,433 and ttable = 2,042 this indicates that tcount > ttable.
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Seaman, Michael S., Béatrice Pérarnau, Kirsten Fischer Lindahl, Francois A. Lemonnier et James Forman. « Response to Listeria monocytogenes in Mice Lacking MHC Class Ia Molecules ». Journal of Immunology 162, no 9 (1 mai 1999) : 5429–36. http://dx.doi.org/10.4049/jimmunol.162.9.5429.
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Abstract MHC class Ia-deficient mice (H2 Kb−/− Db−/−) inoculated with the intracellular pathogen Listeria monocytogenes (LM) displayed a three- to fourfold expansion of splenic CD8+ T cells 6 days following infection. Culture of these spleen cells in vitro gave rise to CTL that recognized LM-infected target cells and were restricted by the class Ib molecules, Qa1b and M3. Exposure of target cells to heat-killed LM (HKLM) rather than live bacteria did not result in CTL-mediated lysis. Target cells pulsed with three LM peptides known to bind M3, f-MIGWII, f-MIVTLF, and f-MIVIL, were recognized by effector cells from both B6 and Kb−/− Db−/− animals. In vivo analysis showed that B6 and Kb−/− Db−/− mice clear LM from the spleen and liver rapidly with similar kinetics, whereas TAP.1−/− mice, which are deficient in class Ia and Ib molecules, clear LM slowly upon infection. To establish the in vivo role of CD8+ T cells in Kb−/− Db−/− animals, we showed that depletion of such cells from the spleens of immune mice prevented the adoptive transfer of protective immunity to syngeneic recipients. Spleen cells from Kb−/− Db−/− mice were also capable of generating responses directed against syngeneic as well as allogeneic class Ia molecules in vitro. Thus, class Ia-deficient animals have a CD8+ T cell repertoire capable of recognizing both class Ia and class Ib molecules and can generate protective immunity to LM.
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do Nascimento, J. D., A. Lèbre, R. Konstantinova-Antova et J. R. de Medeiros. « Lithium Abundances in Fast Rotating Bright Giant Stars ». Symposium - International Astronomical Union 215 (2004) : 246–47. http://dx.doi.org/10.1017/s0074180900195671.
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We present the results of high resolution spectroscopic observations of Li I resonance doublet at λ 6707.8 Å for fast rotating single stars of luminosity class II and Ib. We present a discussion on the link between rotation and Li content in intermediate mass giant stars, with emphasis on their evolutionary status. At least one of the observed stars, HD 232862, a G8II with an unusual vsini of 20 km/s, present a Li-rich behavior.
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Barberis, Laura, et Emilio Hirsch. « Targeting phosphoinositide 3-kinase γ to fight inflammation and more ». Thrombosis and Haemostasis 99, no 02 (2008) : 279–85. http://dx.doi.org/10.1160/th07-10-0632.
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SummaryThe family of class I phosphoinositide-3-kinase (PI3K) is composed of four lipid kinases involved at multiple levels in innate and adaptive immune responses. Class I PI3Ks are divided into two subclasses, IA and IB, sharing a similar catalytic core. Whereas class IA PI3Ks are primarily activated by receptor tyrosine kinases, the unique element of class IB PI3K (PI3Kγ) is activated by G protein coupled receptors (GPCRs), like chemokine receptors. PI3Kγ is mainly expressed in leukocytes where it plays a significant role in chemotaxis. Here, we report recent advances in the analysis of the role of PI3Kγ in leukocytes and in endothelial cells. Results, derived from studies based on both pharmacological and genetic approaches, confirm PI3Kγ as an attractive target for drug discovery. PI3Kγ specific inhibition has gained increasing attention for the treatment of allergic, autoimmune and inflammatory diseases. Development of inhibitors has already provided series of hits, whose efficacy is currently under scrutiny worldwide.
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Mandell, Jason G., Kenneth L. Hill, Dan T. D. Nguyen, Kevin W. Moser, Robert E. Harbaugh, James McInerney, Brian Kaaya Nsubuga et al. « Volumetric brain analysis in neurosurgery : Part 3. Volumetric CT analysis as a predictor of seizure outcome following temporal lobectomy ». Journal of Neurosurgery : Pediatrics 15, no 2 (février 2015) : 133–43. http://dx.doi.org/10.3171/2014.9.peds12428.
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OBJECT The incidence of temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) can be high in developing countries. Current diagnosis of MTS relies on structural MRI, which is generally unavailable in developing world settings. Given widespread effects on temporal lobe structure beyond hippocampal atrophy in TLE, the authors propose that CT volumetric analysis can be used in patient selection to help predict outcomes following resection. METHODS Ten pediatric patients received preoperative CT scans and temporal resections at the CURE Children's Hospital of Uganda. Engel classification of seizure control was determined 12 months postoperatively. Temporal lobe volumes were measured from CT and from normative MR images using the Cavalieri method. Whole brain and fluid volumes were measured using particle filter segmentation. Linear discrimination analysis (LDA) was used to classify seizure outcome by temporal lobe volumes and normalized brain volume. RESULTS Epilepsy patients showed normal to small brain volumes and small temporal lobes bilaterally. A multivariate measure of the volume of each temporal lobe separated patients who were seizure free (Engel Class IA) from those with incomplete seizure control (Engel Class IB/IIB) with LDA (p < 0.01). Temporal lobe volumes also separate normal subjects, patients with Engel Class IA outcomes, and patients with Class IB/IIB outcomes (p < 0.01). Additionally, the authors demonstrated that age-normalized whole brain volume, in combination with temporal lobe volumes, may further improve outcome prediction (p < 0.01). CONCLUSIONS This study shows strong evidence that temporal lobe and brain volume can be predictive of seizure outcome following temporal lobe resection, and that volumetric CT analysis of the temporal lobe may be feasible in lieu of structural MRI when the latter is unavailable. Furthermore, since the authors' methods are modality independent, these findings suggest that temporal lobe and normative brain volumes may further be useful in the selection of patients for temporal lobe resection when structural MRI is available.
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Glaser, Hollis F. « Content Analysis of Students' Favorite Magazines : Class Exercise ». Communication Teacher 25, no 4 (octobre 2011) : 189–91. http://dx.doi.org/10.1080/17404622.2011.601722.
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Savković, Lazar, Borivoje Aleksić et Dalibor Pešić. « Bridges on the road network of state roads of the IB class and data required for the analysis of road safety on the bridge ». Put i saobraćaj 68, no 1 (21 mars 2022) : 27–34. http://dx.doi.org/10.31075/pis.68.01.05.
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Bridges are structures designed to bridge natural or artificial obstacles, such as watercourses, valleys, railways, or roads. The purpose of the bridge is to allow people and vehicles to cross a certain obstacle. This paper presents the results of research conducted in the period from 2019 to 2020 on bridges on state roads of the IB class in the Republic of Serbia. The applied methodology in collecting inventory data on bridges in order to form a basic database on bridges is presented. Also, the connection of certain data in order to conduct analyzes of bridge road safety is presented. A total of 974 bridges were identified. The paper also presents the analysis of road crashes that occurred on state roads of the IB class with a specific place "bridge", where the most common types of road crashes in the bridge zone were discovered. At the end of the paper, a critical review is given of certain elements of the bridge that may have an impact on road safety.
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Chen, Lili, Xiao He, Attila Kumanovics, Jared Fairbanks et Peter Jensen. « Murine MHC class Ib gene T11 : a functional paralog of T23/Qa-1 ? (106.42) ». Journal of Immunology 188, no 1_Supplement (1 mai 2012) : 106.42. http://dx.doi.org/10.4049/jimmunol.188.supp.106.42.
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Abstract MHC class Ia molecules, H2-K/D/L in mouse, select CD8 T cells during development and present peptides to appropriate CD8 T cells in immune responses. Mouse MHC class Ib H2-Q, T, M regions contain more than 20 protein-encoding genes, but only few have been studied. Qa-1, encoded by H2-T23 gene, is one of the best-studied MHC class Ib. Qa-1 presents peptide generated from MHC Ia to NKG2A/CD94 receptors and provides inhibitory signal to NK cells. Here, we report the study of another MHC class Ib gene, H2-T11. T11 is 95% identical in DNA level and 87% identical in protein level to T23. T11 mRNA was detected in spleen, thymus and uterus in B6 mice, and its expression pattern is more limited than that of T23. Recombinant T11 was refolded with β2m, with or without the exogenous Qdm peptides. The refolded T11 had a typical secondary structure of MHC class I proteins, shown by circular dichroism analysis. The refolded T11 bound Qdm in vitro and could be recognized by a Qa-1 specific mAb. T11 was ectopically expressed on the surface of several cell lines, including a Tap deficient one. The T11 expressing cells could not present insulin to Qa-1 restricted, insulin-specific T cell hybridoma, in contrast to T23 expressing cells. Our results indicated that despite a high similarity to T23, T11 might have different function from T23/Qa-1. We are in the process of eluting naturally bound peptides from T11 expressing cells, and using T11/Qdm tetramers to look for its potential ligand(s).
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Podlipnik, Sebastian, Aram Boada, Jose L. López-Estebaranz, Manuel M. Martín-González, Pedro Redondo, Brian Martin, Ann P. Quick et al. « Using a 31-Gene Expression Profile Test to Stratify Patients with Stage I–II Cutaneous Melanoma According to Recurrence Risk : Update to a Prospective, Multicenter Study ». Cancers 14, no 4 (19 février 2022) : 1060. http://dx.doi.org/10.3390/cancers14041060.
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Background: Fifteen to forty percent of patients with localized cutaneous melanoma (CM) (stages I–II) will experience disease relapse. The 31-gene expression profile (31-GEP) uses gene expression data from the primary tumor in conjunction with clinicopathologic features to refine patient prognosis. The study’s objective was to evaluate 31-GEP risk stratification for disease-free survival (DFS) in a previously published cohort with longer follow-up. Methods: Patients with stage IB–II CM (n = 86) were prospectively tested with the 31-GEP. Follow-up time increased from 2.2 to 3.9 years. Patient outcomes were compared using Kaplan-Meier and Cox regression analysis. Results: A Class 2B result was a significant predictor of 3-year DFS (hazard ratio (HR) 8.4, p = 0.008) in univariate analysis. The 31-GEP significantly stratified patients by risk of relapse (p = 0.005). A Class 2B result was associated with a lower 3-year DFS (75.0%) than a Class 1A result (100%). The 31-GEP had a high sensitivity (77.8%) and negative predictive value (95.0%). Conclusions: The 31-GEP is a significant predictor of disease relapse in patients with stage IB–II melanoma and accurately stratified patients by risk of relapse.
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Magalhães, Roberto, Beatriz Nogueira, Samaritana Costa, Nádia Paiva, João M. Ferra, Fernão D. Magalhães, Jorge Martins et Luisa H. Carvalho. « Effect of Panel Moisture Content on Internal Bond Strength and Thickness Swelling of Medium Density Fiberboard ». Polymers 13, no 1 (30 décembre 2020) : 114. http://dx.doi.org/10.3390/polym13010114.
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Wood-based products usually have serious limitations concerning contact with water, both because wood is a hygroscopic material and because the commonly used binder has low moisture resistance. This paper studies the effect of panel moisture content (MC) on the physico-mechanical properties of medium density fiberboards (MDF). Several commercial MDF boards produced in Europe were stored at room temperature and relative humidity (RH) for 9 weeks (approx. range 15–20 °C and 50–85% RH). Every week, a strip of each MDF board was cut out, divided into 5 × 5 cm test pieces and its internal bond strength (IB) was measured. A strong influence of MDF moisture content on internal bond strength was observed and therefore IB test pieces were stored in a climatic chamber (either at 20 °C, 55% RH and at 20 °C, 70% RH). A decreasing linear relation was established between IB and MC. It was found that this effect is reversible: after drying, internal bond strength rises again (following a slight hysteresis). This work reinforces the importance of conditioned storage before board properties analysis, as described in European Standard EN 319.
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Dickerson, Tyler, Tracy Wiczer, Allyson Waller, Jennifer Philippon, Devin Haddad, Avirup Guha, Kyle Porter et al. « Hypertension Development, Management, and Cardiovascular Events Following Ibrutinib Initiation for Hematologic Malignancies ». Blood 132, Supplement 1 (29 novembre 2018) : 4423. http://dx.doi.org/10.1182/blood-2018-99-110345.
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Abstract Background Ibrutinib (IB), a nonselective Bruton's tyrosine kinase inhibitor, is associated with significantly improved disease control rates, progression free, and overall survival in several B-cell malignancies. Yet, IB's nonselective actions may result in a number of unintended adverse effects and complications that can lead to drug discontinuation. New or worsening hypertension (HTN) has been reported in 10-29% of those receiving IB within clinical trials. However, recent observational data suggest that this rate may be much higher in clinical practice and resistant to treatment. The management of IB-related HTN has not been previously well described. Furthermore, the relationship between IB-associated HTN and serious cardiovascular (CV) complications is unknown. Therefore, we sought to characterize the incidence, risk factors, management, and CV complications associated with IB-related HTN across long-term follow-up. Methods We performed a retrospective, single-center cohort study of all consecutive adult patients treated with IB for a hematologic malignancy from 2009-2016. Patient demographics, blood pressure (BP), antihypertensive therapy, cancer variables, and CV complications were collected throughout the duration of IB therapy. HTN was defined as systolic BP of ≥ 130 mmHg on 2 separate visits within 3 months. Worsened HTN was defined as an increase in HTN grade by Common Terminology Criteria for Adverse Events (CTCAE) or an increase an antihypertensive therapy. The composite of major adverse CV endpoint (MACE), including atrial fibrillation, ventricular arrhythmia, myocardial infarction, cerebrovascular accident, heart failure, and CV death, as stratified by HTN status was assessed. Univariate and multivariate Fine and Gray regression analyses accounting for competing risks of death and IB-discontinuation were preformed to determine the association between baseline covariates and outcomes, and survival analysis techniques were used to estimate the cumulative incidence of events. To assess whether any antihypertensive agent(s) was more effective in preventing IB-related HTN, the use of these agents at baseline was assessed by class, as protective factors against worsened HTN. Results Overall, 562 patients treated with IB were identified, a majority of which had CLL (73%) and were male (70%); mean age 64 ± 11 years. Sixty-two percent had preexisting HTN at the time of starting IB with 35% requiring at least one antihypertensive medication. During follow-up, 440 (78%) developed new or worsening HTN (figure 1A), with a mean increase in systolic BP of 5.2 mmHg (± 20.7). In those without baseline HTN, 72% developed new HTN while on IB, with a mean increase in systolic BP of 13.4 mmHg (± 20.1). Among patients with preexisting HTN, 82% saw worsening of their BP (mean increase in systolic BP of 4.1 mmHg (± 21.4)), including increased CTCAE grade in 77% and new antihypertensive medications in 46% of patients. Estrogen/progestin use [HR 3.47, 95% CI (1.25-9.64)] and history of diabetes [HR 1.66, 95% CI (1.03-2.66)] were risk factors for new, but not worsened HTN on multivariable analysis. MACE occurred in 19.1% of patients with new or worsened HTN, compared to 8.2% of patients with no HTN (figure 1B). In a multivariable model containing traditional HTN risk factors, new or worsened HTN was not significantly associated with MACE [HR 1.98, 95% CI (0.74-5.31)]. No specific class of antihypertensive agent was associated with the prevention of worsened HTN. Conclusion In this retrospective study, IB-therapy was associated with a substantial increase in the incidence and severity of HTN. Further research into the mechanisms, early detection strategies, optimal management, and clinical impacts of this complication are needed. Disclosures No relevant conflicts of interest to declare.
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Talekar, Mala Kiran, Joshua E. Allen et Wafik S. El-Deiry. « ONC201(TIC10) Induces TRAIL and Cell Death In Preclinical Models Of Pediatric Lymphoma ». Blood 122, no 21 (15 novembre 2013) : 1671. http://dx.doi.org/10.1182/blood.v122.21.1671.1671.
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Background The outcome for pediatric Non-Hodgkin Lymphomas (NHL) using conventional treatment standards is still inferior compared to other childhood malignancies, particularly in advanced stage and relapsed disease. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an endogenous protein that induces apoptosis selectively in cancer cells by binding to death receptors. Previous TRAIL-targeting strategies have had limited potential due to unfavorable biodistribution and pharmacokinetics. Our laboratory identified a small molecule, ONC201(TIC10), which induces p53 independent TRAIL gene transcription and TRAIL-dependent cell death and overcomes the most critical efficacy-limiting drug properties of available TRAIL-based therapies. Selective advantages of ONC201 include longer half-life, stimulation of TRAIL and death receptor expression, stability, lower production cost, and ability to cross the intact blood-brain barrier. Our lab has reported that ONC201 is orally active, has potent anti-tumor effects in several preclinical animal cancer models including prolonging survival in lymphoma bearing Eu-myc transgenic mice, exhibits synergy with several antitumor agents (Allen JE et al, Sci Transl Med.,2013) and is being developed into a first-in-man study in advanced cancer patients in early 2014. Objective Assess monoagent activity and mechanism of action of ONC201 in pediatric lymphoma. Derive preclinical rationale to evaluate ONC201 as a novel targeted therapy for pediatric lymphoma as a monoagent or in combination in clinical trials. Methods A diverse sub-type panel of human lymphoma cell lines [Ramos, Raji and Daudi (Burkitt's lymphoma); Karpas299 (T-cell NHL); UPN2 and Granta (Mantle Cell lymphoma)] was selected to assess lymphoma sensitivity to ONC201. Luminescent cell viability assay was used to generate inhibition curves at 72 hours post-treatment with ONC201 yielding IC50's. Caspase-based Apoptosis assay was performed on cells treated with low micromolar dose ranges of ONC201 and data generated via flow cytometry at 72 hours post-treatment. Surface TRAIL expression was analyzed via FACS (Fluorescence-activated cell-sorting) at 60 hours post-treatment. Inhibition of ONC201-induced Apoptosis was demonstrated using Pan-caspase inhibitor (Z-VAD-FMK) at 72 hour post-treatment. Western blot analysis of representative cell lines from the three sub-types (Ramos, Karpas299 and UPN2) at 48 hour post-treatment with ONC201 for AKT and ERK was used to validate the mechanism of induction of apoptosis of lymphoma cells by ONC201. Results Cell viability assays demonstrated sharp dose-response curves at 72 hours post-treatment with ONC201. Quantitative analysis of these relationships yielded ONC201 IC50 values in the range of 1.3 to 5.06 uM, which is comparable to reported activity of ONC201 in other tumor types. Sub-G1 analysis by flow cytometry revealed significant levels of apoptosis at 72 hours post-treatment in a dose-dependent manner (Fig.1) with substantial increase in sub-G1 content (range 1.8-fold to 4.15-fold) in comparison with that of untreated cells. Treatment with ONC201 revealed increase in surface TRAIL expression in a dose dependent manner across the representative cell lines. ONC201 induced apoptosis was demonstrably inhibited using Pan-caspase inhibitor. Western blot analysis of representative cell lines from the three sub-types (Ramos, Karpas299 and UPN2) at 48 hour post-treatment with ONC201 confirmed dual inhibition of Akt and ERK as potential mechanism of induction of apoptosis of lymphoma cells by ONC201. Conclusion ONC201 is a first-in-class therapy that has apoptotic activity in human lymphoma cells at low micromolar concentrations and promotes up-regulation of TRAIL. ONC201 is promising as a monoagent and may be enhanced by combination with approved therapies to improve the standard of care for pediatric NHL. We are currently assessing in vitro synergistic tumor cell-killing by standard chemotherapeutic agents used to treat lymphoma in combination with ONC201. We plan to translate our work in vivo using xenograft mice models. The ultimate goal of this project is to provide the preclinical rationale for a potential phase Ib trial of ONC201 as a combination therapy in pediatric lymphoma. Disclosures: Allen: ONCOCEUTICS: Employment; ONCOCEUTICS: Equity Ownership. El-Deiry:ONCOCEUTICS: Equity Ownership.
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O'callaghan, Christopher A., Andrew J. McMichael, John I. Bell, Charlie D. Blundell, Bent K. Jakobsen, Benjamin E. Willcox, José Tormo, David I. Stuart et E. Yvonne Jones. « Production, crystallization, and preliminary X-ray analysis of the human MHC class Ib molecule HLA-E ». Protein Science 7, no 5 (mai 1998) : 1264–66. http://dx.doi.org/10.1002/pro.5560070525.
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Septiarini, Friska Hadi. « The Use of Audiovisual Media to Improve the Speech Skills of Private School Students ». Social, Humanities, and Educational Studies (SHEs) : Conference Series 3, no 3 (26 novembre 2020) : 617. http://dx.doi.org/10.20961/shes.v3i3.46040.
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<em>This study aims to improve speaking skills through the use of audiovisual media in class IB SD Negeri Suro, Kalibagor District. Speaking skills observed in this study include linguistic and non-linguistic aspects. In the linguistic aspect, it consists of stress, speech, vocabulary / diction, and sentence structure, while in the non-linguistic aspect it consists of fluency, disclosure of speech material, courage and attitude. This type of research is Classroom Action Research (CAR) which consists of 2 cycles. The subjects of this study were 22 students of SD Negeri Suro class IB. The research design used includes the planning, implementation, observation, and reflection stages. The data collection instruments used were performance tests, teacher and student observation sheets and documentation. The data analysis technique used is descriptive quantitative data analysis. This study shows that the use of audiovisual media can improve the speaking skills of grade IB SD Negeri Suro students in terms of process and outcome. The process improvement is seen from the average results of student activity observations which are included in the good category in the first cycle with a percentage of 45.5% increasing in the second cycle to 68% and are included in the very good category. In terms of results, it is evidenced by the average value of students' speaking skills in pre-action 67.54 increased to 73.05 in cycle I and increased to 75.64 in cycle II. </em>
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Ranaswijaya, Ranaswijaya, Ari Kristin et Muhlis Muhlis. « Analisis Determinan Efisiensi Bank Umum Syariah Indonesia Dengan Variabel Moderating Profitabilitas ». MALIA : Journal of Islamic Banking and Finance 3, no 1 (11 avril 2019) : 73. http://dx.doi.org/10.21043/malia.v3i1.8091.
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<p class="Normal tm5"><em><span class="tm6"> The purpose of this study is to examine the effect of Non Performing Financing (NPF) and Bank Size on the profitability and efficiency level of Islamic Commercial Banks, as well as the effect of profitability if it moderates the effect of Non Performing Financing (NPF) and Bank Size on the level of efficiency of Islamic Commercial Banks. The level of efficiency is obtained through efficiency analysis with Data Envelopment Analysis (DEA), The variables of input output consist of tabungan iB, giro iB, and deposito iB, while output consist of murabahah financing, mudharabah financing, musyarakah financing,and investment in securities. Data used during the period 2014-2017 which includes 13 Islamic Commercial Banks. The results of the study indicate that Bank Victoria Syariah achieved optimal efficiency values and the lowest efficiency of Bank Syariah Bukopin. The results of the hypothesis indicate that Non Performing Financing (NPF) has a significant negative effect on profitability and the level of efficiency of Islamic commercial banks. Bank size has no significant positive effect on profitability and has no significant negative effect on the efficiency of Islamic commercial banks. Profitability has no significant positive effect on the level of efficiency, and is not able to significantly moderate the influence of NPF and bank size on the level of efficiency of Islamic commercial banks.</span></em></p>
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Ramadhan, Rezky. « Proses Perceraian Dari Perkawinan Yang Tidak Terdaftar Di Pengadilan Agama Kelas IB Pariaman ». Journal of Education, Humaniora and Social Sciences (JEHSS) 5, no 3 (21 février 2023) : 2436–48. http://dx.doi.org/10.34007/jehss.v5i3.1639.
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This article aims to find out the factors that cause unregistered marriages, the process, and the legal consequences of divorce from marriages that have been legalized at the Religious Court class IB Pariaman. The problem is focused on divorce from unregistered marriages which is a real problem in society, especially in the area of the Religious Courts of Pariaman. To approach this problem, the research method used in this article is sociological juridical, namely field studies to obtain primary data in the field of law which will be analyzed with laws and regulations related to the divorce process in marriages that are not registered at the Pariaman religious court class IB. The data was collected through in-depth interviews with related parties, such as the young clerk of the legal division of the Class IB Pariaman religious court. In this in-depth interview, the questions were used as an interview guide and the mobile phone was used as a voice recorder during the interview and analyzed in a descriptive analysis where the research did not only provide an overview but also wrote down and reported an object that became a legal event which would draw general conclusions in the case. researched. This study concludes that the legal consequences that result in divorce from a marriage that has been entered into are in terms of child custody, such as losing the right to have a loss certificate, and in terms of inheritance, such as the wife not receiving inheritance rights from her husband.
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Ruan, CG, XP Du, XD Xi, PA Castaldi et MC Berndt. « A murine antiglycoprotein Ib complex monoclonal antibody, SZ 2, inhibits platelet aggregation induced by both ristocetin and collagen ». Blood 69, no 2 (1 février 1987) : 570–77. http://dx.doi.org/10.1182/blood.v69.2.570.570.
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Abstract A new monoclonal antibody (MoAb), SZ 2, reactive with the human platelet glycoprotein Ib complex has been produced by the hybridoma technique. SZ 2 immunoprecipitated the components of the glycoprotein Ib complex, glycoprotein Ib and glycoprotein IX, from Triton-X-100- solubilized, periodate-labeled platelets. Western blot analysis indicated that the epitope for SZ 2 was on the alpha-subunit of glycoprotein Ib. Scatchard analysis of SZ 2 binding to formaldehyde- fixed, washed platelets revealed a single class of binding sites with Kd = 6.6 +/- 3.3 X 10(-10) mol/L and 15,200 +/- 4,100 binding sites per platelet (mean +/- SD, n = 10). Intact antibody and its purified (Fab')2 fragments not only inhibited the ristocetin-dependent binding of von Willebrand factor to platelets and ristocetin-induced platelet agglutination but also inhibited platelet aggregation induced by Type I collagen and platelet-activating factor (PAF). SZ 2 inhibited platelet serotonin and beta-thromboglobulin release in response to these stimuli and also platelet thromboxane A2 formation in response to ristocetin and collagen. SZ 2 was without effect on platelet aggregation or release in response to other platelet stimuli such as ADP, thrombin, or arachidonic acid. The inhibition by SZ 2 of collagen- and PAF-induced platelet aggregation is surprising in that Bernard-Soulier syndrome platelets, which lack the glycoprotein Ib complex, respond normally to both these stimuli. SZ 2 was unreactive toward Bernard-Soulier syndrome platelets, as evaluated by fluorescence-associated cell sorting, and had no effect on the collagen- and PAF-induced aggregation of Bernard- Soulier syndrome platelets. The combined results suggest that the inhibition by SZ 2 of collagen- and PAF-induced aggregation of normal platelets is steric and are consistent with the glycoprotein Ib complex and the platelet collagen and PAF receptor(s) being adjacent in the human platelet plasma membrane.
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Ruan, CG, XP Du, XD Xi, PA Castaldi et MC Berndt. « A murine antiglycoprotein Ib complex monoclonal antibody, SZ 2, inhibits platelet aggregation induced by both ristocetin and collagen ». Blood 69, no 2 (1 février 1987) : 570–77. http://dx.doi.org/10.1182/blood.v69.2.570.bloodjournal692570.
Texte intégralRésumé :
A new monoclonal antibody (MoAb), SZ 2, reactive with the human platelet glycoprotein Ib complex has been produced by the hybridoma technique. SZ 2 immunoprecipitated the components of the glycoprotein Ib complex, glycoprotein Ib and glycoprotein IX, from Triton-X-100- solubilized, periodate-labeled platelets. Western blot analysis indicated that the epitope for SZ 2 was on the alpha-subunit of glycoprotein Ib. Scatchard analysis of SZ 2 binding to formaldehyde- fixed, washed platelets revealed a single class of binding sites with Kd = 6.6 +/- 3.3 X 10(-10) mol/L and 15,200 +/- 4,100 binding sites per platelet (mean +/- SD, n = 10). Intact antibody and its purified (Fab')2 fragments not only inhibited the ristocetin-dependent binding of von Willebrand factor to platelets and ristocetin-induced platelet agglutination but also inhibited platelet aggregation induced by Type I collagen and platelet-activating factor (PAF). SZ 2 inhibited platelet serotonin and beta-thromboglobulin release in response to these stimuli and also platelet thromboxane A2 formation in response to ristocetin and collagen. SZ 2 was without effect on platelet aggregation or release in response to other platelet stimuli such as ADP, thrombin, or arachidonic acid. The inhibition by SZ 2 of collagen- and PAF-induced platelet aggregation is surprising in that Bernard-Soulier syndrome platelets, which lack the glycoprotein Ib complex, respond normally to both these stimuli. SZ 2 was unreactive toward Bernard-Soulier syndrome platelets, as evaluated by fluorescence-associated cell sorting, and had no effect on the collagen- and PAF-induced aggregation of Bernard- Soulier syndrome platelets. The combined results suggest that the inhibition by SZ 2 of collagen- and PAF-induced aggregation of normal platelets is steric and are consistent with the glycoprotein Ib complex and the platelet collagen and PAF receptor(s) being adjacent in the human platelet plasma membrane.
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Hoesni, Fachroerrozi, et Firmansyah Firmansyah. « Analisis Faktor Teknis dan Non Teknis Keberhasilan Inseminasi Buatan pada Kawasan Sentra Ternak Sapi di Kabupaten Tebo ». Jurnal Ilmiah Universitas Batanghari Jambi 19, no 1 (26 janvier 2019) : 204. http://dx.doi.org/10.33087/jiubj.v19i1.591.
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The success of artificial insemination (IB) in the central area of beef cattle in the Tebo based on technical or non technical indicators are still not satisfactory. To increase the success of the IB to do an analysis of the determinants of the success of the IB in terms of technical factors, as well as non technical factors. The purpose of this research is to analyze the keragaan success rate of IB, and to analyze the effect of technical and non technical factor towards the success of the IB on beef cattle in the central area of Bali cattle in the Tebo. Research methods used in this research is a survey and laboratory techniques, with the withdrawal of sample Cluster Random Sampling that is the central area of beef cattle in the Tebo. The sample size in this study were determined by using the iterati method. Measuring qualitative variables used questionnaire form questions with Scala Likert's Summated Rating's. Validity or kesakhihan research results is determined by measuring instrument which is used i.e. testing the validity of a test (test of validity) and reliability (reliability test of) instruments. The scale of measurement data obtained are ordinal scale that is varied and the ratio. For the ordinal scale of research data done transformation into interval scale using Method of Succesive Interval (MSI). To analyze the effect of the hormone content of inseminator, skills and mineral feed, body condition score and motility of the sperm toward the success rate of artificial insemination in cattle at Tebo Regency in the used path analysis (path analysis).
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Isnania, Rahma, Nanang Martono et Tri Rini Widyastuti. « Symbolic Violence in Children’s Stories : Content Analysis in Bobo Magazine ». Society 8, no 2 (30 décembre 2020) : 677–94. http://dx.doi.org/10.33019/society.v8i2.238.
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The upper-class dominates various social spaces in society, including children’s stories. Children’s stories as a means of socializing values also participate in socializing upper-class habitus in the storyline. This study aims to describe the children’s habitus as narrated in short stories published in Bobo magazine. The method used in this study is the quantitative content analysis method and critical discourse analysis. This study’s object is about 174 short stories published in Bobo magazine from January 2019 to August 2020, of which 110 stories were taken randomly as samples. The results show that most of the children’s habitus narrated in the stories were upper-class children’s habitus, reaching out to 87 or 79.1% of all stories. Meanwhile, lower-class children’s habitus was found in 30.9% of all stories. The habitus of upper-class children featured in the story consisting of go on an excursion, luxury living, own electronic goods, own expensive good, wearing nightgowns, reading, and writing. On the other side, the habitus of lower-class children habitus featured in the story consisting of playing traditional games, living in poverty, and doing lower-class work. In conclusion, the upper-class children’s habitus appears more dominantly within short stories in Bobo magazine. This study’s results are expected as recommend to parties related to children’s stories publication to present more balanced stories.
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Ferreira, Manuel Portugal, Dan Li, Stephen Guisinger et Fernando A. Ribeiro Serra. « Is the International Business Environment the actual context for international business research ? » Revista de Administração de Empresas 49, no 3 (septembre 2009) : 282–94. http://dx.doi.org/10.1590/s0034-75902009000300004.
Texte intégralRésumé :
The International Business Environment (IBE) has been argued to be the essential context for international business (IB) studies and the distinguishing factor from other management studies and studies of large enterprises. Two content analysis show that many papers published in top tier IB journals either lack reference to any dimension of the IBE or tend to be uni-or bi-dimensional when addressing the IBE; it is not a surprise that the cultural dimension is the most often used. We suggest that: (a) there is need to developed more uni-and multi-dimensional environmental constructs; (b) a more holistic view of the IBE provides richer insights on the actual complexity underlying IB research. Future studies that provide more comprehensive models of the IBE that overcome the usual broad classifications of the international environment as undefined and uncontrollable factors are warranted to advance conceptual and empirical research.
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Roberts, Joanne, et Christoph Dörrenbächer. « Challenging the orthodox : a decade of critical perspectives on international business ». critical perspectives on international business 10, no 1/2 (25 février 2014) : 2–20. http://dx.doi.org/10.1108/cpoib-12-2013-0053.
Texte intégralRésumé :
Purpose – This article reflects on the development and impact of critical perspectives on international business (CPoIB) during its first decade of existence. The influence that the journal has had through its efforts to challenge orthodox understandings of international business (IB) is considered. The evolution of CPoIB is set against the changing global environment. The contributions to this 10th anniversary issue are outlined. Design/methodology/approach – The journal's contents are reviewed and their impact assessed through an analysis of download and citation data. The position of the journal in various journal quality rankings is also examined. The contents of mainstream IB journals are compared to those of CPoIB. Findings – During its short life, CPoIB has had an important impact on the field of IB both directly through the consideration of issues from a critical perspective in the pages of the journal and through its influence on the field of IB and critical management studies. Research limitations/implications – The conclusions of the research are based on nine years of citation and download data as well as journal quality lists. Practical implications – The findings of this paper provide valuable information for authors seeking a quality and impactful outlet for their research in the field of critical perspectives on IB and related disciplines. Academic and political activists in the field of IB will find theoretical backgrounds supporting their political campaigns. Originality/value – This is the only paper to undertake an assessment of the first decade of CPoIB's development, content, and impact.
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Sæle, Øystein, Andreas Nordgreen, Pål A. Olsvik et Kristin Hamre. « Characterisation and expression of secretory phospholipase A2 group IB during ontogeny of Atlantic cod (Gadus morhua) ». British Journal of Nutrition 105, no 2 (14 septembre 2010) : 228–37. http://dx.doi.org/10.1017/s0007114510003466.
Texte intégralRésumé :
The pancreatic enzyme secretory phospholipase A2 group IB (sPLA2 IB) hydrolyses phospholipids at the sn-2 position, resulting in a NEFA and a lyso-phospholipid, which are then absorbed by the enterocytes. The sPLA2 IB is a member of a family of nineteen enzymes sharing the same catalytic ability, of which nine are cytosolic and ten are secretory. Presently, there are no pharmacological tools to separate between the different secretory enzymes when measuring the enzymatic activity. Thus, it is important to support activity data with more precise techniques when isolation of intestinal content is not possible for analysis, as in the case of small teleost larvae, where the whole animal is sometimes analysed. In the present study, we characterise the sPLA2 IB gene in Atlantic cod (Gadus morhua) and describe its ontogeny at the genetic and protein level and compare this to the total sPLA2 activity level. A positive correlation was found between the expression of sPLA2 IB mRNA and protein. Both remained stable and low during the larval stage followed by an increase from day 62 posthatch, coinciding with the development of the pyloric ceaca. Meanwhile, total sPLA2 enzyme activity in cod was stable and relatively high during the early stages when larvae were fed live prey, followed by a decrease in activity when the fish were weaned to a formulated diet. Thus, the expression of sPLA2 IB mRNA and protein did not correlate with total sPLA2 activity.
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Joyce, S., P. Tabaczewski, R. H. Angeletti, S. G. Nathenson et I. Stroynowski. « A nonpolymorphic major histocompatibility complex class Ib molecule binds a large array of diverse self-peptides. » Journal of Experimental Medicine 179, no 2 (1 février 1994) : 579–88. http://dx.doi.org/10.1084/jem.179.2.579.
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Unlike the highly polymorphic major histocompatibility complex (MHC) class Ia molecules, which present a wide variety of peptides to T cells, it is generally assumed that the nonpolymorphic MHC class Ib molecules may have evolved to function as highly specialized receptors for the presentation of structurally unique peptides. However, a thorough biochemical analysis of one class Ib molecule, the soluble isoform of Qa-2 antigen (H-2SQ7b), has revealed that it binds a diverse array of structurally similar peptides derived from intracellular proteins in much the same manner as the classical antigen-presenting molecules. Specifically, we find that SQ7b molecules are heterodimers of heavy and light chains complexed with nonameric peptides in a 1:1:1 ratio. These peptides contain a conserved hydrophobic residue at the COOH terminus and a combination of one or more conserved residue(s) at P7 (histidine), P2 (glutamine/leucine), and/or P3 (leucine/asparagine) as anchors for binding SQ7b. 2 of 18 sequenced peptides matched cytosolic proteins (cofilin and L19 ribosomal protein), suggesting an intracellular source of the SQ7b ligands. Minimal estimates of the peptide repertoire revealed that at least 200 different naturally processed self-peptides can bind SQ7b molecules. Since Qa-2 molecules associate with a diverse array of peptides, we suggest that they function as effective presenting molecules of endogenously synthesized proteins like the class Ia molecules.
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Fisk, Harold A., et Michael P. Yaffe. « Mutational Analysis of Mdm1p Function in Nuclear and Mitochondrial Inheritance ». Journal of Cell Biology 138, no 3 (11 août 1997) : 485–94. http://dx.doi.org/10.1083/jcb.138.3.485.
Texte intégralRésumé :
Nuclear and mitochondrial transmission to daughter buds of Saccharomyces cerevisiae depends on Mdm1p, an intermediate filament-like protein localized to numerous punctate structures distributed throughout the yeast cell cytoplasm. These structures disappear and organelle inheritance is disrupted when mdm1 mutant cells are incubated at the restrictive temperature. To characterize further the function of Mdm1p, new mutant mdm1 alleles that confer temperature-sensitive growth and defects in organelle inheritance but produce stable Mdm1p structures were isolated. Microscopic analysis of the new mdm1 mutants revealed three phenotypic classes: Class I mutants showed defects in both mitochondrial and nuclear transmission; Class II alleles displayed defective mitochondrial inheritance but had no effect on nuclear movement; and Class III mutants showed aberrant nuclear inheritance but normal mitochondrial distribution. Class I and II mutants also exhibited altered mitochondrial morphology, possessing primarily small, round mitochondria instead of the extended tubular structures found in wild-type cells. Mutant mdm1 alleles affecting nuclear transmission were of two types: Class Ia and IIIa mutants were deficient for nuclear movement into daughter buds, while Class Ib and IIIb mutants displayed a complete transfer of all nuclear DNA into buds. The mutations defining all three allelic classes mapped to two distinct domains within the Mdm1p protein. Genetic crosses of yeast strains containing different mdm1 alleles revealed complex genetic interactions including intragenic suppression, synthetic phenotypes, and intragenic complementation. These results support a model of Mdm1p function in which a network comprised of multimeric assemblies of the protein mediates two distinct cellular processes.
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Batavia, Edgar Lucero. « Asking about Content and Adding Content : two Patterns of Classroom Interaction ». Colombian Applied Linguistics Journal 14, no 1 (29 juin 2012) : 28. http://dx.doi.org/10.14483/22487085.3811.
Texte intégralRésumé :
This research project focuses on identifying and describing the interactional patterns and the speech acts that emerge and are maintainedthrough teacher-student interactions in a university-level EFL Pre-intermediate class. This work also analyzes how these patterns potentiallyinfluence the participants’ interactional behavior. This study then answers two questions: what interactional patterns emerge and how they arestructured in interactions between the teacher and the students in the EFL class? And, how can the utterances that compose the interactionalpatterns potentially influence both interactants’ interactional behavior in the EFL class? The description and analysis of the problem followethnomethodological conversation analysis. The findings show that there are two main interactional patterns in the EFL class observed for thisstudy: asking about content, and adding content. Both patterns present characteristic developments and speech acts that potentially influencethe teacher and students’ interactional behavior in this class. These findings serve as a reference and evidence for the interactional patterns thatemerge in EFL classroom interaction and the influence they have on the way both interactants use the target language in classroom interaction.
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Rosenfeld, Catherine, Pia Solt-Rindler, Wilfried Sailer-Kronlachner, Thomas Kuncinger, Johannes Konnerth, Andreas Geyer et Hendrikus W. G. van Herwijnen. « Effect of Mat Moisture Content, Adhesive Amount and Press Time on the Performance of Particleboards Bonded with Fructose-Based Adhesives ». Materials 15, no 23 (6 décembre 2022) : 8701. http://dx.doi.org/10.3390/ma15238701.
Texte intégralRésumé :
The study evaluates the performance of laboratory, single-layered particleboards made out of fructose-hydroxymethylfurfural-bishexamethylenetriamine (SusB) adhesive as a sustainable alternative. Several production parameters such as mat moisture content (MMC), adhesive amount and press time were varied and their effect on the bonding efficiency investigated. The internal bond strength (IB) and thickness swelling after 24 h of water immersion (TS) were taken as evaluation criteria for the bonding efficiency. pMDI-bonded particleboards were produced as fossil-based, formaldehyde-free reference. Particleboard testing was complemented by tensile shear strength measurements and thermal analysis. It was found that the MMC has the highest impact on the internal bond strength of SusB-bonded particleboards. In the presence of water, the reaction enthalpy of the main curing reaction (occurring at 117.7 °C) drops from 371.9 J/mol to 270.5 J/mol, leading to side reactions. By reducing the MMC from 8.7%, the IB increases to 0.61 N/mm2, thus surpassing P2 requirements of the European standard EN312. At a press factor of 10 s/mm, SusB-bonded particleboards have a similar IB strength as pMDI-bonded ones, with 0.59 ± 0.12 N/mm2 compared to 0.59 ± 0.09 N/mm2. Further research on the improvement of the dimensional stabilization of SusB-bonded PBs is needed, as the TS ranges from 30–40%.
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Watson, Kevin E. « A Comparative Analysis of Method Books for Class Jazz Instruction ». Update : Applications of Research in Music Education 36, no 1 (16 février 2017) : 5–11. http://dx.doi.org/10.1177/8755123317692640.
Texte intégralRésumé :
The purpose of this study was to analyze and compare instructional topics and teaching approaches included in selected class method books for jazz pedagogy through content analysis methodology. Frequency counts for the number of pages devoted to each defined instructional content category were compiled and percentages of pages allotted to each category were calculated. Analyses of supplementary media consisted of noting the duration in seconds that each excerpt devoted to illustrating concepts in each instructional content category. Results indicated that the largest amount of content was devoted to arrangements of tunes for group performance (34%), rhythm section pedagogy (13%), and suggested rehearsal techniques (10%). Of note, the categories of improvisation and aural training each comprised only 3% of the surveyed content. Pedagogical approaches to the emphasized instructional areas were identified and discussed within the context of prior research in jazz pedagogy.
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Carde, Patrice, Robert Timmerman, Minesh P. Mehta, Christopher D. Koprowski, Judith Ford, Roy B. Tishler, Dale Miles, Richard A. Miller et Markus F. Renschler. « Multicenter Phase Ib/II Trial of the Radiation Enhancer Motexafin Gadolinium in Patients With Brain Metastases ». Journal of Clinical Oncology 19, no 7 (1 avril 2001) : 2074–83. http://dx.doi.org/10.1200/jco.2001.19.7.2074.
Texte intégralRésumé :
PURPOSE: Motexafin gadolinium is a magnetic resonance imaging (MRI)–detectable redox active drug that localizes selectively in tumor cells and enhances the effect of radiation therapy. This phase Ib/II trial of motexafin gadolinium, administered concurrently with 30 Gy in 10 fractions whole-brain radiation therapy (WBRT), was conducted to determine maximum-tolerated dose (MTD), dose-limiting toxicity, pharmacokinetics, and biolocalization in patients with brain metastases. Additional endpoints were radiologic response rate and survival. PATIENTS AND METHODS: Motexafin gadolinium was administered before each radiation treatment in this open-label, multicenter, international trial. In phase Ib, drug dose was escalated until the MTD was exceeded. In phase II, drug was evaluated in a narrow dose range. RESULTS: In phase Ib, the motexafin gadolinium dose was escalated in 39 patients (0.3 mg/kg to 8.4 mg/kg). In phase II, 22 patients received 5 mg/kg to 6.3 mg/kg motexafin gadolinium. Ten once-daily treatments were well tolerated. The MTD was 6.3 mg/kg, with dose-limiting reversible liver toxicity. Motexafin gadolinium’s tumor selectivity was established using MRI. The radiologic response rate was 72% in phase II. Median survival was 4.7 months for all patients, 5.4 months for recursive partitioning analysis (RPA) class 2 patients, and 3.8 months for RPA class 3 patients. One-year actuarial survival for all patients was 25%. CONCLUSION: Motexafin gadolinium was well tolerated at doses up to 6.3 mg/kg, was selectively accumulated in tumors, and, when combined with WBRT of 30 Gy in 10 fractions, was associated with a high radiologic response rate.
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Chiu, Nancy M., Taehoon Chun, Miriam Fay, Manas Mandal et Chyung-Ru Wang. « The Majority of H2-M3 Is Retained Intracellularly in a Peptide-Receptive State and Traffics to the Cell Surface in the Presence of N-Formylated Peptides ». Journal of Experimental Medicine 190, no 3 (2 août 1999) : 423–34. http://dx.doi.org/10.1084/jem.190.3.423.
Texte intégralRésumé :
We used a new monoclonal antibody (mAb 130) to analyze the intracellular trafficking and surface expression of H2-M3, the major histocompatibility complex class Ib molecule that presents N-formylated peptides to cytotoxic T cells. M3 surface expression is undetectable in most cell types due to the paucity of endogenous antigen. M3 is induced on the cell surface by addition of high-affinity N-formylated peptides from mitochondria and listeria. Peptide-induced M3 expression is most efficient on antigen presenting cells. Basal and inducible expression of M3 is transporter associated with antigen processing (TAP)-dependent, distinguishing M3 from the class Ib molecules TL and CD1. Unlike the expression of class Ia molecules and a previously described M3/Ld chimera, surface expression of M3 cannot be rescued by lowered temperature, suggesting that the α3 domain and transmembrane region of M3 may control trafficking. Pulse–chase analysis and use of trafficking inhibitors revealed a pool of empty M3 in the endoplasmic reticulum or early Golgi apparatus. Addition of exogenous peptide allows maturation with kinetics matching those of Dd. The lack of endogenous N-formylated peptide allows discovery of novel pathogen-derived peptides in normal antigen presenting cells. The nonpolymorphic nature of M3 and its ability to present bacterial antigens rapidly and dominantly make it an attractive target for peptide vaccination strategies.
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Nursyirwan, Vivi Iswanti, Nina Valentika, Choirul Basir, Gerry Sastro et Ilmadi Ilmadi. « Pembahasan Soal Tes Potensi Skolastik pada SBMPTN 2020 untuk Meningkatkan Kualitas Pelayanan Online di Tengah Pandemi Covid 19 di Bimbel dan Privat MATRIKS ». Indonesia Berdaya 1, no 2 (23 juillet 2020) : 55–60. http://dx.doi.org/10.47679/ib.202029.
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The purpose of community service carried out by the Pamulang University lecturer Team is to provide discussion assistance in answering questions about scholastic potential test to class XII high school students in preparing themselves to take part in the joint selection of state universities (SBMPTN) 2020. Partners in this community service are tutoring and private matrices in Pamulang, South Tangerang, Banten. The subject of community service is students in the public high school class XII who wish to enter state higher education through the SBMPTN 2020 test. The main problem faced by partners is that up to now Bimbel learning media has always been face to face and have never done online learning media, this because technologically Bimbel and private matrix not yet support in providing these services. The solution offered is to do online learning by online meeting application. The direct benefit of this dedication activity is an additional knowledge, skills in solving potential scholastic questions so that students can prepare for the joint selection of 2020 state universities with the method of solving problems quickly and easily. The derivate benefits are expected to be able to make students pass the SBMPTN 2020. This community service activity is carried out in the form of training by providing material and practice of completing the 2020 SBMPTN exam questions. The training is held for two weeks, namely in Monday to Friday, 11 -15 May 2020, and 18-22 May 2020. The method of activities used are practices, questions and answers and discussions. The analysis technique is done by observing aspects of student’s cognition and skills in conquering the subject matter.
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Septiarini, Friska Hadi. « THE USE OF AUDIOVISUAL MEDIA TO IMPROVE THE SPEECH SKILLS OF PRIVATE SCHOOL STUDENTS ». Social, Humanities, and Educational Studies (SHEs) : Conference Series 3, no 3 (15 novembre 2020) : 269. http://dx.doi.org/10.20961/shes.v3i3.45848.
Texte intégralRésumé :
<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p>This study aims to improve speaking skills through the use of audiovisual media in class IB SD Negeri Suro, Kalibagor District. Speaking skills observed in this study include linguistic and non-linguistic aspects. In the linguistic aspect, it consists of stress, speech, vocabulary / diction, and sentence structure, while in the non-linguistic aspect it consists of fluency, disclosure of speech material, courage and attitude. This type of research is Classroom Action Research (CAR) which consists of 2 cycles. The subjects of this study were 22 students of SD Negeri Suro class IB. The research design used includes the planning, implementation, observation, and reflection stages. The data collection instruments used were performance tests, teacher and student observation sheets and documentation. The data analysis technique used is descriptive quantitative data analysis. This study shows that the use of audiovisual media can improve the speaking skills of grade IB SD Negeri Suro students in terms of process and outcome. The process improvement is seen from the average results of student activity observations which are included in the good category in the first cycle with a percentage of 45.5% increasing in the second cycle to 68% and are included in the very good category. In terms of results, it is evidenced by the average value of students' speaking skills in pre-action 67.54 increased to 73.05 in cycle I and increased to 75.64 in cycle II. This shows that students' speaking skills increased from cycle I to cycle II.</p></td></tr></tbody></table></div>
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Kalidas, Savitha, Igor Cestari, Severine Monnerat, Qiong Li, Sandesh Regmi, Nicholas Hasle, Mehdi Labaied, Marilyn Parsons, Kenneth Stuart et Margaret A. Phillips. « Genetic Validation of Aminoacyl-tRNA Synthetases as Drug Targets in Trypanosoma brucei ». Eukaryotic Cell 13, no 4 (21 février 2014) : 504–16. http://dx.doi.org/10.1128/ec.00017-14.
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ABSTRACT Human African trypanosomiasis (HAT) is an important public health threat in sub-Saharan Africa. Current drugs are unsatisfactory, and new drugs are being sought. Few validated enzyme targets are available to support drug discovery efforts, so our goal was to obtain essentiality data on genes with proven utility as drug targets. Aminoacyl-tRNA synthetases (aaRSs) are known drug targets for bacterial and fungal pathogens and are required for protein synthesis. Here we survey the essentiality of eight Trypanosoma brucei aaRSs by RNA interference (RNAi) gene expression knockdown, covering an enzyme from each major aaRS class: valyl-tRNA synthetase (ValRS) (class Ia), tryptophanyl-tRNA synthetase (TrpRS-1) (class Ib), arginyl-tRNA synthetase (ArgRS) (class Ic), glutamyl-tRNA synthetase (GluRS) (class 1c), threonyl-tRNA synthetase (ThrRS) (class IIa), asparaginyl-tRNA synthetase (AsnRS) (class IIb), and phenylalanyl-tRNA synthetase (α and β) (PheRS) (class IIc). Knockdown of mRNA encoding these enzymes in T. brucei mammalian stage parasites showed that all were essential for parasite growth and survival in vitro . The reduced expression resulted in growth, morphological, cell cycle, and DNA content abnormalities. ThrRS was characterized in greater detail, showing that the purified recombinant enzyme displayed ThrRS activity and that the protein localized to both the cytosol and mitochondrion. Borrelidin, a known inhibitor of ThrRS, was an inhibitor of T. brucei ThrRS and showed antitrypanosomal activity. The data show that aaRSs are essential for T. brucei survival and are likely to be excellent targets for drug discovery efforts.