Articles de revues : « I-838 »

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CERSONSKY, JEFF. « Cocaine Abusers as Mothers ». Pediatrics 82, n^o 1 (1 juillet 1988) : 136. http://dx.doi.org/10.1542/peds.82.1.136.

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To the Editor.— I have two points to raise concerning the article by Chasnoff et al (Pediatrics 1987;80:836-838). First, the history of alcohol intake given was consistent with dependency. As an addictionologist working with teenage alcoholics and addicts, I can give you a pretty good assurrance that the alcohol intake related by this mother was a gross underestimation. The physical features of this child lead one to believe that the child did suffer from prenatal maternal abuse and should have been further discussed.

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CHASNOFF, IRA J. « Cocaine Abusers as Mothers ». Pediatrics 82, n^o 1 (1 juillet 1988) : 136–37. http://dx.doi.org/10.1542/peds.82.1.136a.

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In Reply.— I would like to thank Dr Cersonsky for his comments regarding our article (Pediatrics 1987;80:836-838). I certainly agree that the social aspects of a case regarding maternal substance abuse in pregnancy are important in the ultimate prognosis for the exposed child. In our experience with addicted pregnant women, our major work has been pointed toward the importance of early intervention in pregnancy. Unfortunately, the woman reported in this article was not referred to our program, and her physicians never obtained any type of substance abuse history during the pregnancy.

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Li, Yinkui, Xiaoxiao Qin, Wen Li, Xiaoling Wang et Haicheng Ma. « Connected even factors in k-tree ». Open Mathematics 18, n^o 1 (29 décembre 2020) : 1601–5. http://dx.doi.org/10.1515/math-2020-0106.

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Abstract A connected even {[}2,2s] -factor of a graph G is a connected factor with all vertices of degree i(i=2,4,\ldots ,2s) , where s\ge 1 is an integer. In this paper, we show that a \tfrac{k+1}{s+2} -tough k-tree has a connected even {[}2,2s] -factor and thereby generalize the result that a \tfrac{k+1}{3} -tough k-tree is Hamiltonian in [Hajo Broersma, Liming Xiong, and Kiyoshi Yoshimoto, Toughness and hamiltonicity in k-trees, Discrete Math. 307 (2007), 832–838].

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Li, Yinkui, Xiaoxiao Qin, Wen Li, Xiaoling Wang et Haicheng Ma. « Connected even factors in k-tree ». Open Mathematics 18, n^o 1 (1 janvier 2020) : 1601–5. http://dx.doi.org/10.1515/math-2020-0106.

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Abstract A connected even [ 2 , 2 s ] {[}2,2s] -factor of a graph G is a connected factor with all vertices of degree i ( i = 2 , 4 , … , 2 s ) i(i=2,4,\ldots ,2s) , where s ≥ 1 s\ge 1 is an integer. In this paper, we show that a k + 1 s + 2 \tfrac{k+1}{s+2} -tough k-tree has a connected even [ 2 , 2 s ] {[}2,2s] -factor and thereby generalize the result that a k + 1 3 \tfrac{k+1}{3} -tough k-tree is Hamiltonian in [Hajo Broersma, Liming Xiong, and Kiyoshi Yoshimoto, Toughness and hamiltonicity in k-trees, Discrete Math. 307 (2007), 832–838].

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Fang, Ping, Kyle R. Cron, Oanh Pham, Julie R. Janes, John Brandenburg, Fauna Yarza, Bret Peterson, Christopher Thanos, Chan Whiting et Akshata R. Udyavar. « Abstract 576 : ACTM-838, a novel immunotherapy that enriches in solid tumors after IV dosing and comprehensively reverses the immunosuppressive TME to promote durable anti-tumor immunity ». Cancer Research 83, n^o 7_Supplement (4 avril 2023) : 576. http://dx.doi.org/10.1158/1538-7445.am2023-576.

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Abstract ACTM-838 is an avirulent bacterial immunotherapy that encodes an engineered IL-15 (IL-15plex) and a constitutively active STING variant (eSTING). The ACTM-838 strain is a highly modified, attenuated S. Typhimurium that lacks several major inflammatory and immunogenic components on the surface of the microbe and is designed to naturally and specifically enrich in the tumor microenvironment (TME) via auxotrophic dependency on metabolites of the adenosine pathway and purines, to achieve tumor-specific payload delivery. ACTM-838 was selectively internalized by phagocytic, primary human antigen presenting cells (APCs) but not endothelial cells. ACTM-838 was stable in human whole blood and is not inactivated by complement. Human macrophage uptake of labeled ACTM-838 led to acidic lysosomes and nuclear delivery with a concomitant increase in expression of encoded IL-15plex and eSTING payloads such as IL-15, IRF3 reporter activity and IFN ⍺/β secretion, respectively. Primary human and murine macrophages polarized towards a dual co-stimulatory and phagocytic M1/M2 dual phenotype in response to ACTM-838. ACTM-838 delivered eSTING payload in STING knockout macrophages and induced significantly higher Type I IFN production over a negative control strain. IV delivered ACTM-838 showed dose and payload dependent tumor enrichment and potent single-agent efficacy in two independent syngeneic tumor models, EMT6 (orthotopic) and MC38. Sustained memory anti-tumor immunity upon tumor rechallenge in cured animals was demonstrated. ACTM-838 treated tumors exhibited a significant increase in human IL-15plex protein payload. ACTM-838 as a single agent induced profound immune reprogramming and remodeling of the TME over time through increased infiltration and activation of myeloid, NK, B and cytolytic CD8 T cells, MHC class I and II, antigen presentation as well as decreased Treg, PD1+Lag3+ exhausted T cells, and a remodeled stromal signature, as assessed by bulk RNAseq, and confirmed by flow cytometry. Synergistic anti-tumor activity was observed in multiple tumor models when ACTM-838 was dosed in combination with anti-PD1, safely inducing complete responses. No significant body weight loss or death was observed in any treatment regimens of ACTM-838 alone (single or multiple doses) or in combination with anti-PD1. Analyses of public RNAseq datasets from patients with primary or metastatic disease revealed cancer types with high levels of myeloid infiltration and adenosine enrichment, suggesting that ACTM-838 efficacy could provide benefit in these indications. ACTM-838 is a novel immunotherapy delivering IL-15plex + eSTING payloads to phagocytic APCs, inducing a durable anti-tumor immune response, after IV dosing. It possesses a compelling safety profile, and is currently in IND-enabling, preclinical development. Citation Format: Ping Fang, Kyle R. Cron, Oanh Pham, Julie R. Janes, John Brandenburg, Fauna Yarza, Bret Peterson, Christopher Thanos, Chan Whiting, Akshata R. Udyavar. ACTM-838, a novel immunotherapy that enriches in solid tumors after IV dosing and comprehensively reverses the immunosuppressive TME to promote durable anti-tumor immunity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 576.

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Peelen, E., A. Muehler, D. Vitt et H. Kohlhof. « P064 IMU-838, a Small Molecule DHODH Inhibitor in Phase 2 Clinical Trial for Ulcerative Colitis, Shows Potent Anti-inflammatory Activity in Cell-Culture-Based and In Vivo Systems ». Journal of Crohn's and Colitis 16, Supplement_1 (1 janvier 2022) : i172—i173. http://dx.doi.org/10.1093/ecco-jcc/jjab232.193.

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Abstract Background IMU-838 (vidofludimus calcium) is a well-tolerated and orally available small molecule inhibitor of dihydroorotate dehydrogenase (DHODH) and is currently in phase 2 clinical development for ulcerative colitis (UC). Here, we investigated the effect of IMU-838 on different immune cell subsets and analysed the mechanism of action in more detail in T cells. Methods The effect of IMU-838 on regulatory macrophages (Mregs) was investigated by adding IMU-838 or anti-TNFα antibodies (infliximab, adalimumab), alone or in combination, in a mixed lymphocyte reaction assay, determining Mregs (CD206+CD14+) by FACS analysis. To investigate the effect of IMU-838 on human T and B cells, PBMC were stimulated with PHA (48h) or Oligonucleotide 2006-PTO (70h), respectively. An affinity-dependent effect of IMU-838 was assessed on CD8 T cells from OT-I and OT-III mice, containing a high and a low affinity T cell receptor (TCR), respectively, for OVA257-264 peptide. These cells were stimulated with ovalbumin (OVA) peptide loaded splenocytes or anti-CD3/anti-CD28 for 3 days. Oxidative phosphorylation (OXPHOS) and glycolysis in murine T cells was investigated by the Seahorse/Agilent technique in murine CD4 and CD8 T cells activated with anti-CD3/anti-CD28 with or without IMU-838. Results IMU-838 slightly induced Mregs, but strongly and dose-dependently decreased TNFα and IL-6 secretion. Anti-TNFα antibodies alone strongly induced Mregs, but also increased IL-6 levels. When IMU-838 was added, Mregs induction was even higher, and IL-6 was reduced. Besides reducing proinflammatory cytokines secreted by macrophages, IMU-838 also inhibits proliferation of activated B and T cells, as well as inflammatory T cell cytokine secretion, IL-17A, IL-17F and IFNγ, and increased apoptosis up to 3-fold compared to vehicle control. By investigating IMU-838’s role on affinity related activity status of T cells, it was shown that IMU-838 strongly inhibited cell proliferation in the peptide stimulated high affinity, but not in the low affinity, CD8 T cells. Peptide stimulated high affinity T cells show an upregulation of OXPHOS and glycolysis pathways, which are involved in the generation of the cell’s energy supply, compared to low affinity cells. IMU-838 strongly inhibited OXPHOS and glycolysis in both CD4 and CD8 T cells. Conclusion IMU-838 reduces the proinflammatory immune cell response by inducing Mregs, reducing pro-inflammatory cytokine secretion and reducing immune cell proliferation. DHODH is only important in cells that received a strong stimulus and are highly metabolically active. Therefore, IMU-838 will only specifically target these cells and will still allow for a normal immune response, representing a huge safety advantage for treatment of IBD patients.

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Kehoe, Haixing, Alexandre Iannello, Keith Cheung, Bret Peterson, Marie Marotel, Sara Tribble, Hailey He et al. « 853 ACTM-838 : a microbial-based immunotherapy that delivers combination IL-15 + engineered STING to tumor-resident APCs after IV dosing in T-cell excluded solid tumors ». Journal for ImmunoTherapy of Cancer 9, Suppl 2 (novembre 2021) : A894. http://dx.doi.org/10.1136/jitc-2021-sitc2021.853.

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BackgroundIn a metastatic setting, systemically-administered therapies that overcome the immunosuppressive tumor microenvironment to promote T-cell recruitment and T-cell cytolytic function will be required to elicit durable anti-tumor immunity. To accomplish this, the STACT (S. Typhimurium-Attenuated Cancer Therapy) platform was developed. STACT is a live bacterial product that has been highly modified using precision genome editing for the following properties: (1) enhanced tolerability after IV dosing, (2) tumor-specific enrichment, (3) phagocytosis by tumor-resident antigen-presenting cells (APCs) with a lack of epithelial cell infectivity, (4) multiplexed genetic cargo delivery, and (5) attenuation of bacterial pathways that impair CD8+ T-cell function. An extensive screening campaign was performed to identify ideal encoded immunomodulatory payload combinations delivered by STACT for efficacy against T-cell excluded tumors.MethodsChromosomal edits to the STACT platform strain were made using PCR. A panel of immunomodulatory proteins, including cytokines, type I interferon (IFN)-inducing factors, co-stimulatory receptors, checkpoint antibodies and TGFβR-Fc decoys were tested for combinatorial potency using STACT. An engineered STING (eSTING) was designed through an extensive protein engineering campaign to identify optimal variants. Combinations were evaluated in primary human APCs using in vitro functional assays, where STACT IL-15Rα-IL-15 (IL-15) + eSTING (ACTM-838) emerged as a lead candidate. ACTM-838 was then evaluated in multiple murine tumor models for therapeutic efficacy and mechanism, as well as tolerability in rodents and primates after systemic administration.ResultsCombinatorial target profiling led to the discovery of ACTM-838, a STACT encoding IL-15 + eSTING. In vitro, ACTM-838 payloads synergistically produced high levels of type I IFN and T-cell recruitment and activation factors from primary human APCs. In vivo, ACTM-838 demonstrated a high degree of complete tumor responses that were entirely CD8+ T-cell dependent. In an autochthonous breast cancer model that lacks any significant lymphocyte infiltrate, ACTM-838 was able to uniformly enrich in each spontaneous lesion to high levels after IV dosing and resulted in significant CD8+ T-cell infiltration. In primates, ACTM-838 was well-tolerated, rapidly cleared, and elicited minimal cytokine response after IV dosing.ConclusionsACTM-838 is a highly attenuated, precision genome-engineered bacterial immunotherapy that delivers IL-15 + eSTING to phagocytic APCs of the solid tumor microenvironment after systemic administration. In preclinical studies, ACTM-838 promotes CD8+ T-cell mediated tumor clearance in T-cell excluded tumors and elicits durable anti-tumor immunity, and is well tolerated in primates. Based on these data, ACTM-838 was nominated for clinical development and has entered cGMP manufacturing and IND-enabling studies.Ethics ApprovalAll animals were used according to protocols approved by an Institutional Animal Care and Use Committee and maintained in specific pathogen-free conditions in a barrier facility.

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Reeve, Michael D. « Ovid Met. 15, 838 : an apology (of sorts) to Loriano Zurli ». AL. Rivista di studi di Anthologia Latina 13 (novembre 2022) : 95–102. http://dx.doi.org/10.1484/j.alat.5.133359.

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Lu, William, Kyle Cron, Julie Janes, Leigh Berryman, Gurvinder Singh, Christopher Thanos et Akshata Udyavar. « Abstract 736 : ACTM-838 safely and comprehensively re-activates the immunosuppressive TME by exploiting myeloid biology intrinsic in many cancers ». Cancer Research 84, n^o 6_Supplement (22 mars 2024) : 736. http://dx.doi.org/10.1158/1538-7445.am2024-736.

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Abstract ACTM-838 is a genetically modified bacterial vehicle encoding a DNA plasmid with two engineered payloads, IL-15plex and constitutively active eSTING. The bacterial vehicle is a highly attenuated S. typhimurium, engineered to facilitate safe IV administration. ACTM-838 is designed to specifically enrich in the TME via auxotrophic dependency on extracellular adenosine and purine metabolites. ACTM-838 is then selectively internalized by tumor-resident myeloid cells achieving tumor-specific payload delivery. Previously, we showed ACTM-838 exhibited significant and durable anti-tumor efficacy across syngeneic tumor mouse models (EMT6 breast, MC38 colon) and MMTV-PyMT GEMM. To elucidate TME changes induced by ACTM-838, EMT6 tumors were analyzed post-treatment by scRNA-seq, which demonstrated that ACTM-838 induced significant transcriptional changes in several cell populations in the TME. Cytolytic pathways were upregulated in T and NK cells, while type I IFN and PDL1 were upregulated in myeloid populations consistent with previous bulk RNAseq analyses. To understand the tolerability and safety of ACTM-838, a GLP toxicology study was performed on naïve cynomolgus monkeys (NHP). No ACTM-838-related clinical or veterinary observations were reported at any dose level. Acute dose-dependent increases in serum cytokines were observed at 4 hours which reverted to baseline by 24 hours. ACTM-838 was cleared from blood by 24 hours post-dose with no significant shedding in urine or feces. ACTM-838 was only detected in the spleen in 2 and 1 animals at 22- and 49-days post treatment, respectively. Pre-existing ADA was observed in some animals with subsequent increases in ADA upon dosing in most animals. However, no correlation of serum ADA and blood PK levels suggested that the presence of ADA does not impact drug stability. The ACTM-838 mechanism of action requires high levels of adenosine or purine metabolites to enrich and colonize the TME as well as phagocytic internalization by tumor-intrinsic myeloid cells to achieve tumor-specific payload delivery. Myeloid cells comprise roughly half of all cells in the TME in human tumors. Bioinformatics analyses of the public patient datasets identified key tumor indications enriched in both adenosine and myeloid pathways. To further understand the spatial heterogeneity in the TME across tumors, we performed multiplex immunofluorescence on patient tumor microarrays to validate tumor types with a high prevalence of myeloid populations coupled with an active adenosine pathway, which will help guide future clinical study design. In summary, we demonstrate that ACTM-838 modulates the TME and is stable and safe in animal models. Additionally, our studies recommend the prioritization of certain tumor indications for treatment with ACTM-838 in the clinic. Citation Format: William Lu, Kyle Cron, Julie Janes, Leigh Berryman, Gurvinder Singh, Christopher Thanos, Akshata Udyavar. ACTM-838 safely and comprehensively re-activates the immunosuppressive TME by exploiting myeloid biology intrinsic in many cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 736.

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Cáceres-Vásquez, Joaquín, Danilo H. Jara, Juan Costamagna, Fabián Martínez-Gómez, Carlos P. Silva, Luis Lemus, Eleonora Freire, Ricardo Baggio, Cristian Vera et Juan Guerrero. « Correction : Effect of non-covalent self-dimerization on the spectroscopic and electrochemical properties of mixed Cu(i) complexes ». RSC Advances 13, n^o 17 (2023) : 11296. http://dx.doi.org/10.1039/d3ra90033a.

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Correction for ‘Effect of non-covalent self-dimerization on the spectroscopic and electrochemical properties of mixed Cu(i) complexes’ by Joaquín Cáceres-Vásquez et al., RSC Adv., 2023, 13, 825–838, https://doi.org/10.1039/D2RA05341A.

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Hahn, Friedrich, Christina Wangen, Sigrun Häge, Antonia Sophia Peter, Gerhard Dobler, Brett Hurst, Justin Julander et al. « IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro ». Viruses 12, n^o 12 (5 décembre 2020) : 1394. http://dx.doi.org/10.3390/v12121394.

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The ongoing pandemic spread of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) demands skillful strategies for novel drug development, drug repurposing and cotreatments, in particular focusing on existing candidates of host-directed antivirals (HDAs). The developmental drug IMU-838, currently being investigated in a phase 2b trial in patients suffering from autoimmune diseases, represents an inhibitor of human dihydroorotate dehydrogenase (DHODH) with a recently proven antiviral activity in vitro and in vivo. Here, we established an analysis system for assessing the antiviral potency of IMU-838 and DHODH-directed back-up drugs in cultured cell-based infection models. By the use of SARS-CoV-2-specific immunofluorescence, Western blot, in-cell ELISA, viral yield reduction and RT-qPCR methods, we demonstrated the following: (i) IMU-838 and back-ups show anti-SARS-CoV-2 activity at several levels of viral replication, i.e., protein production, double-strand RNA synthesis, and release of infectious virus; (ii) antiviral efficacy in Vero cells was demonstrated in a micromolar range (IMU-838 half-maximal effective concentration, EC50, of 7.6 ± 5.8 µM); (iii) anti-SARS-CoV-2 activity was distinct from cytotoxic effects (half-cytotoxic concentration, CC50, >100 µM); (iv) the drug in vitro potency was confirmed using several Vero lineages and human cells; (v) combination with remdesivir showed enhanced anti-SARS-CoV-2 activity; (vi) vidofludimus, the active determinant of IMU-838, exerted a broad-spectrum activity against a selection of major human pathogenic viruses. These findings strongly suggest that developmental DHODH inhibitors represent promising candidates for use as anti-SARS-CoV-2 therapeutics.

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Chudzikowska-Wołoszyn, Małgorzata. « Proweniencja oraz funkcja teorii kosmologicznych następstw niesprawiedliwych rządów w zwierciadle Jonasza z Orleanu (ok. 780-843) ». Vox Patrum 79 (15 septembre 2021) : 67–82. http://dx.doi.org/10.31743/vp.12288.

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Celem niniejszego artykułu jest przybliżenie popularnej pośród moralistów karolińskich VIII i IX w. idei, mówiącej o kosmologicznych konsekwencjach królowania. Przekonanie o tym, że grzechy króla mogą zagrozić całej społeczności było szczególnie silnie akcentowane w piśmiennictwie o charakterze wzorcotwórczym oraz napominającym. Tym samym motyw ten odnajdujemy w tak licznie powstających w czasie panowania Karola Wielkiego (747-814) i Ludwika Pobożnego (778-840) listach do władców oraz zwierciadłach. Podstawą podjętych w pracy analiz jest zwierciadło książęce (speculum principis) – De institutione regia - które ok. 831 r. biskup Orleanu Jonasz napisał dla cesarskiego syna Pepina I, króla Akwitanii (797-838). W III rozdziale tego dzieła zawarta została swoistego rodzaju kosmologiczna reguła władzy, zgodnie z którą pomiędzy kondycją cnót panującego a stanem jego ziemi i ludzi istniała ścisła i szczególna korelacja. Niesprawiedliwy król burzył bowiem równowagę kosmosu. Sprowadzał na swój lud klęski żywiołowe, choroby oraz śmierć. Autorka skoncentruje się na omówieniu proweniencji owej kosmologicznej idei współzależności pomiędzy sprawiedliwością króla i porządkiem kosmosu. Odniesie się również do jej roli w retoryce, którą przyjął Jonasz z Orleanu. W artykule – komparatystycznie - przywołane zostaną także inne zwierciadła karolińskie, podejmujące temat kosmologicznych konsekwencji królowania.

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Lowe, J. C. B. « The Cook Scene of Plautus' Pseudolus ». Classical Quarterly 35, n^o 2 (décembre 1985) : 411–16. http://dx.doi.org/10.1017/s0009838800040258.

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H. Dohm has amply demonstrated how the cook of Plautus, Pseud. 790ff. exhibits characteristic features of the mageiros of Greek comedy. He has also argued, however, that this scene contains substantial Plautine expansion, comparable with that which has been recognised in the cook scene of the Aulularia. I wish to suggest that Dohm is largely right but that the Plautine expansion is even more extensive than he supposes.In 790–838 Plautus is probably for the most part following his Greek model fairly closely. One can trace a logical sequence of ideas, as follows. Ballio: ‘I couldn't have found a worse cook’ (792–7). Cook: ‘Why did you hire me then?’ (798–9a). Ballio: ‘You were the only one left. And why was that?’ (799b–801a). Cook: ‘I am expensive, but nowadays people look for cheap cooks, who produce only concoctions of seasoned vegetables. That is why men are so short-lived’ (801b–25). Ballio: ‘You can make men live longer then?’ (826–8a). Cook: ‘Certainly, for 200 years’ (828b–30). The cook then proceeds to give a list of his fantastic sauces for fish and meat (834f. Neptuni/terrestris pecudes), until he is cut short by Ballio's ‘Damn your lies’ (836–8). We have here a typical comic mageiros: he is loquacious and boastful (794 multiloquom, gloriosum), claims magic powers (829f.), denigrates his rivals (810–25), reels off lists of foods, real and fictitious (814–17, 831–6), and uses grandiose language (834f. Neptuni pecudes).Within this essentially Greek section there are three short passages which look like Plautine additions. First, Dohm is surely right, following E. Fraenkel, to see 790f. as a Plautine addition.

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Neate, G. J. « Creep crack growth in steel at 838 K I : Behaviour at a constant load ». Materials Science and Engineering 82 (septembre 1986) : 59–76. http://dx.doi.org/10.1016/0025-5416(86)90095-9.

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Li, Chennan, et Andrea L. Kasinski. « Abstract 838 : Loss of Arp2/3 activity promotes anchorage independent growth in KRAS;TP53-mutated human bronchial epithelial cells ». Cancer Research 82, n^o 12_Supplement (15 juin 2022) : 838. http://dx.doi.org/10.1158/1538-7445.am2022-838.

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Abstract Mutated KRAS and TP53 are well recognized drivers of multiple human cancers including lung cancer, the leading cause of cancer-associated deaths. Yet, directly targeting mutated KRAS or restoring wildtype p53 levels in KRAS/p53-mutated tumors still remains a therapeutic challenge. A rational alternative approach involves targeting potentiators of KRAS;p53-driven tumorigenesis, which represents one of the research ambitions pioneered by the National Cancer Institute (NCI) RAS initiative to meet this challenge. Therefore, we aimed to identify genes, that when lost, potentiate cellular transformation of a non-transformed KRAS;TP53-mutated human bronchial epithelial cell line (HBEC-KP). To address this question, a genome-wide selection experiment was performed using CRISPR/Cas9. Anchorage-independent (AI) growth, a hallmark of cancer, was selected as a phenotypic readout for one experiment. Without additional genetic perturbation, wildtype HBEC-KP cells were incapable of AI growth. Only certain mutants were capable of supporting colony formation in soft agar. These clones were isolated and the integrated small guide RNAs (sgRNAs) were identified. Genes that are targeted by the sgRNAs were then individually knocked out for validation. Through this approach, we discovered that loss of ARPC3 is sufficient for promoting AI growth in the HBEC-KP cells. This contribution to AI growth is attributed to the role that ARPC3 plays in regulating Arp2/3 activity, as inactivating the Arp2/3 complex using a small molecule inhibitor, CK666 also promoted colony growth in the HBEC-KP cells. We determined that ARPC3 loss was not sufficient to drive AI – in the absence of KRAS activation and p53 loss colony growth was not observed. This indicates the essential role that mutated KRAS and/or p53 play to support AI. To test if mutated KRAS is essential for the phenotype, the Arp2/3 complex was inactivated in KRAS-mutated HBECs, which supported AI growth. This suggests that mutated KRAS and loss of Arp2/3 activity are sufficient for driving AI growth in HBECs. However, combined loss of p53 and ARPC3 failed to drive the phenotype, implicating that mutated KRAS is required. In addition, the Arp2/3 complex is essential for maintaining lamellipodial shape via actin filament network and cell motility, which was validated in our HBEC-KP-ARPC3 knockout cells. However, this protein complex is also known to promote AI growth and development of various cancers, as opposed to acting as a suppressor for growth. Multiple mechanisms that lead to this growth phenotype are currently being explored. Clinical relevance is also being closely examined to further understand the role of the Arp2/3 complex in cancer. Citation Format: Chennan Li, Andrea L. Kasinski. Loss of Arp2/3 activity promotes anchorage independent growth in KRAS;TP53-mutated human bronchial epithelial cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 838.

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Kolaczko, Jensen G., Derrick M. Knapik et Michael J. Salata. « Peri-operative pain management in hip arthroscopy : a systematic review of the literature ». Journal of Hip Preservation Surgery 6, n^o 4 (7 novembre 2019) : 353–63. http://dx.doi.org/10.1093/jhps/hnz050.

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Abstract The purpose of this article was to review current literature on peri-operative pain management in hip arthroscopy. A systematic review of the literature on pain control in hip arthroscopy published January 2008 to December 2018 was performed. Inclusion criteria consisted of English language or articles with English translations, subjects undergoing hip arthroscopy with documented peri-operative pain control protocols in studies reporting Level I to IV evidence. Exclusion criteria were non-English articles, animal studies, prior systematic review or meta-analyses, studies not reporting peri-operative pain control protocols, studies documenting only pediatric (<18 years of age) patients, studies with Level V evidence and studies including less than five subjects. Statistical analysis was performed to assess pain protocols on narcotic consumption in PACU, VAS score on discharge, time to discharge from PACU and incidence of complications. Seventeen studies were included, comprising 1674 patients. Nerve blocks were administered in 50% of patients (n = 838 of 1674), of which 88% (n = 740 of 838) received a pre-operative block while 12% (n = 98 of 838) post-operative block. Sixty-eight complications were recorded: falls (54%, n = 37), peripheral neuritis (41%, n = 28), seizure (1.5%, n = 1), oxygen desaturation and nausea (1.5%, n = 1) and epidural spread resulting in urinary retention (1.5%, n = 1). No significant differences in narcotic consumption, VAS score at discharge, time until discharge or incidence of complication was found based on pain control modality utilized. No statistically significant difference in PACU narcotic utilization, VAS pain scores at discharge, time to discharge or incidence of complications was found between peri-operative pain regimens in hip arthroscopy.

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Kołodziej, Marcin. « Kierowanie świętą liturgią według Magnum principium. Komentarz do kan. 838 Kodeksu Prawa Kanonicznego z 1983 roku ». Kościół i Prawo 11, n^o 2 (30 décembre 2022) : 97–119. http://dx.doi.org/10.18290/kip22112.6.

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Liturgia stanowi przestrzeń szczególnego spotkania teologii i prawa. Nawet, jeśli niektórym wydaje się, że powinna być ona ograniczona tylko do wymiaru czysto mistycznego, bo widzi się w niej specjalny rodzaj modlitwy, to w rzeczywistości jej kształt jest dokładnie określony przez normy prawa kościelnego. Krytyczna ocena Kodeksu Prawa Kanonicznego z 1983 r. musiała uwzględnić obiektywne stwierdzenie, że nie każdy przepis w nim określony i zawarty oddał w sposób precyzyjny sensus Ecclesiae twórców i uczestników Soboru Watykańskiego II. Tak było chociażby w przypadku kan. 838 KPK/83. Zawarte w nim normy odnoszące się do adaptacji i akomodacji oraz określające zasady współpracy pomiędzy Stolicą Apostolską a lokalnymi konferencjami biskupów wymagały uzgodnienia z przepisami przyjętymi już w ramach obrad Soboru Watykańskiego II. Dlatego na mocy listu apostolskiego motu proprio Magnum principium papież dokonał stosownych zmian, które uczyniły współpracę Stolicy Apostolskiej i konferencji biskupów jeszcze sprawniejszą i bardziej owocną w służbie wiernym. Ponadto dzięki tej nowelizacji modlitwa liturgiczna ma być bardziej przystosowana do zrozumienia ludzi.

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Mendonça, João Josué Walmor de. « A EXPROMISSÃO E OS SEUS EFEITOS – EFICÁCIA DA NOVAÇÃO E O ARTIGO 838, I DO CÓDIGO CIVIL ». Nucleus 6, n^o 1 (20 avril 2009) : 159–67. http://dx.doi.org/10.3738/1982.2278.160.

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Jakubiak, Tomasz. « Marcin Kołodziej, Adaptacje i akomodacje w liturgii. Komentarz do kan. 838 Kodeksu prawa kanonicznego, Kraków : Wydawnictwo Scriptum 2023 ». Roczniki Nauk Prawnych 33, n^o 1 (28 août 2023) : 103–10. http://dx.doi.org/10.18290/rnp23331.6.

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Miceli, Antonino, Armin Rest, Christopher W. Stubbs, Suzanne L. Hawley, Kem H. Cook, Eugene A. Magnier, Kevin Krisciunas, Edward Bowell et Bruce Koehn. « Evidence for Distinct Components of the Galactic Stellar Halo from 838 RR Lyrae Stars Discovered in the LONEOS‐I Survey ». Astrophysical Journal 678, n^o 2 (10 mai 2008) : 865–87. http://dx.doi.org/10.1086/533484.

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Flaga, Jerzy. « [Recenzja] : Jan Walkusz, Kościół na drogach pomorskiej przeszłości. Studia i szkice z XIX i XX wieku, Wydawnictwo KUL, Lublin 2014, ss. 387. ISBN 978-83-7702-838-4 ». Archiwa, Biblioteki i Muzea Kościelne 102 (18 décembre 2014) : 431–36. http://dx.doi.org/10.31743/abmk.12018.

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Lisøy, Carina, et Kristin Martinsen. « Måleegenskaper ved den norske versjonen av Beck Anxiety Inventory for ungdom og unge voksne (BAI) ». PsykTestBarn 13, n^o 1 (23 février 2023) : 1–16. http://dx.doi.org/10.21337/0080.

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Beskrivelse: Beck Anxiety Inventory (BAI) er et selvrapporteringsinstrument for angstsymptomer utviklet av Beck, Epstein, Brown og Steer i 1988. Norsk versjon ble oversatt av Tone Andersen i 2005, og rettighetshavere er NCS Pearson Inc. BAI inneholder 21 ledd målt på en 4 poengs Likert-skala som danner en sumskår. Målgruppen er ungdommer eller voksne fra alderen 17 år og oppover. Skjemaet tar 5 – 10 minutter å fylle ut for respondenter med normale leseferdigheter. Fortolkning krever kompetanse tilsvarende klinisk psykolog eller lege. Litteratursøk: Vi søkte etter skandinaviske publikasjoner som rapporterte måleegenskaper eller normdata for BAI i utvalg av ungdom eller unge voksne med gjennomsnittsalder under 26 år. Av 838 referanser, ble 13 inkluderte. Bare én av publikasjonene (en masteroppgave) var en psykometrisk studie. Psykometri: En studie fant at deltakere med angstdiagnoser skåret høyere på BAI enn deltakere med depresjon. Kriterievaliditet for BAI ble undersøkt i en publikasjon, som rapporterte at BAI hadde lav diagnostisk nøyaktighet. Konvergerende validitet, vurdert ved korrelasjonskoeffisienter mellom BAI og andre angstmål, varierte fra «utilstrekkelig» til «utmerket». Faktorstruktur ble undersøkt i en publikasjon, som ikke var fagfellevurdert, og det er stor usikkerhet knyttet til faktorstrukturen til BAI i skandinaviske utvalg, og også internasjonalt. Indre konsistens var rapportert i 11 publikasjoner, og alle fant høy indre konsistens for samlede BAI skårer. God til utmerket test-retest reliabilitet ble funnet i tre publikasjoner. BAI normdata, indikasjoner på endringssensitivitet eller måleinstrumentets invarians ble ikke funnet rapportert i de inkluderte publikasjonene. Konklusjon: Måleegenskapene til den skandinaviske versjonen av BAI er i liten grad dokumentert i utvalg av ungdom eller unge voksne i Skandinavia. Vi anbefaler å benytte måleinstrumentet med forsiktighet blant ungdom og unge voksne frem til gode måleegenskaper av skandinaviske versjoner av BAI er dokumentert.

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Fujimoto, Masanobu, Jane C. Khoury, Philip R. Khoury, Bhanu Kalra, Ajay Kumar, Patrick Sluss, Claus Oxvig, Vivian Hwa et Andrew Dauber. « Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood ». European Journal of Endocrinology 182, n^o 3 (mars 2020) : 363–74. http://dx.doi.org/10.1530/eje-19-0859.

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Objective Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that cleaves IGFBP-3 and IGFBP-5. Human mutations in PAPPA2 result in short stature with a low percentage of free IGF-I. Little is known about PAPP-A2 levels and the regulation of free IGF-I throughout childhood. We examined PAPP-A2 and intact IGFBP-3 levels in childhood and explored associations between PAPP-A2, free and total IGF-I, and total and intact IGFBP-3 and their relationship to the percentage of free to total IGF-I and anthropometric factors. Design Cross-sectional study at a single center. Methods PAPP-A2, free IGF-I, and intact IGFBP-3 levels were measured in childhood (3–18 years old) and an evaluation of the relationship between these proteins and anthropometric factors. Results In 838 children, PAPP-A2 consistently decreased throughout childhood. In contrast, free IGF-I increased. A pubertal peak in free IGF-I was present in females but was less evident in males. Intact and total IGFBP-3 increased throughout childhood; however, intact IGFBP-3 had a more marked rise than total IGFBP-3. Percent free IGF-I decreased with no distinct pubertal peak. PAPP-A2 levels positively correlated with the percent free IGF-I (Male, Female; r = 0.18, 0.38; P < 0.001) and negatively with intact IGFBP-3 (Male, Female; r = −0.58, −0.65; P < 0.0001). Conclusions This is the first study to describe serum PAPP-A2 and intact IGFBP-3 in children between 3 and 18 years of age. Our correlative findings suggest that PAPP-A2 is an important regulator of the percent free IGF-I which can be a marker of perturbations in the GH/IGF-I axis.

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Yao, Yu, Dandan Sang, Liangrui Zou, Dong Zhang, Qingru Wang, Xueting Wang, Liying Wang, Jie Yin, Jianchao Fan et Qinglin Wang. « Enhanced Photoluminescence and Electrical Properties of n-Al-Doped ZnO Nanorods/p-B-Doped Diamond Heterojunction ». International Journal of Molecular Sciences 23, n^o 7 (30 mars 2022) : 3831. http://dx.doi.org/10.3390/ijms23073831.

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The hydrothermal approach has been used to fabricate a heterojunction of n-aluminum-doped ZnO nanorods/p-B-doped diamond (n-Al:ZnO NRs/p-BDD). It exhibits a significant increase in photoluminescence (PL) intensity and a blue shift of the UV emission peak when compared to the n-ZnO NRs/p-BDD heterojunction. The current voltage (I-V) characteristics exhibit excellent rectifying behavior with a high rectification ratio of 838 at 5 V. The n-Al:ZnO NRs/p-BDD heterojunction shows a minimum turn-on voltage (0.27 V) and reverse leakage current (0.077 μA). The forward current of the n-Al:ZnO NRs/p-BDD heterojunction is more than 1300 times than that of the n-ZnO NRs/p-BDD heterojunction at 5 V. The ideality factor and the barrier height of the Al-doped device were found to decrease. The electrical transport behavior and carrier injection process of the n-Al:ZnO NRs/p-BDD heterojunction were analyzed through the equilibrium energy band diagrams and semiconductor theoretical models.

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Mirabel Alviz, Mario, Benito León del Barco, Santiago Mendo Lázaro et Damián Iglesias Gallego. « Rol predictivo de la inteligencia emocional y la actividad física sobre el autoconcepto físico en escolares ». Sportis. Scientific Journal of School Sport, Physical Education and Psychomotricity 6, n^o 2 (17 avril 2020) : 308–26. http://dx.doi.org/10.17979/sportis.2020.6.2.5844.

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El propósito de esta investigación fue analizar el rol predictivo de la inteligencia emocional y la importancia concedida a la realización de la actividad física, sobre el autoconcepto físico en escolares. Tomaron parte en el estudio un total de 838 sujetos con edades comprendidas entre los 9 y los 12 años. Se usaron los instrumentos AF-5 (Autoconcepto), EQ-i: YV “Inteligencia emocional para niños y adolescentes”, y una pregunta diseñada concretamente para el estudio en el que se valora la importancia que los escolares otorgan a la actividad física. El análisis discriminante llevado a cabo encontró que el estado de ánimo y la importancia de la actividad física predecían de forma significativa el autoconcepto físico. Se sugiere la contribución de los contextos educativos y sociales en el desarrollo de la inteligencia emocional, así como la promoción de la actividad física, por la relevancia en el proceso de construcción del autoconcepto físico.

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Zanardi, Odair Carlos, Vânia Beatriz Cipriani et Juliana Garlet. « Leafcutter Ants in Southern Amazon Forests, Brazil ». Journal of Agricultural Science 10, n^o 11 (15 octobre 2018) : 242. http://dx.doi.org/10.5539/jas.v10n11p242.

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This study aims to identify the species of leafcutter ants, the infestation rate and the spatial distribution of anthills in forest plantations in Alta Floresta-MT. The samples were collected in five plots, with I and II being a Eucalyptus urophylla × Eucalyptus grandis hybrid plantation, III a consortium of Brazil nuts (Bertholletia excelsa) and rubber tree (Hevea brasiliensis), IV and V plots of Tectona grandis. The size of the anthills were measured, obtaining the area in square meters of loose ground, were classified into size classes I: ≤ 1 m2; class II: 1.1 to 2.9 m2; class III: 3 to 8.9 m2; class IV: 9 to 25 m2 e class V: > 25 m2. To calculate dispersion, the Dispersion (DI) and Morisita Index (IϬ) were used. Only one species was observed in all plots (Atta sexdens rubropilosa Forel, 1908). 838 nests were mapped in the five sampled plots, the total average density of anthills found in the plots was 26 anthills/ha. The average total area of loose soil occupied by anthills was 590.05 m2, the distribution of anthills between size classes showed 86.87% disproportion with the anthills in class I. The distribution of the anthills in the five plots that were evaluated were of the aggregate type, following the Morisita Index and the Dispersion index.

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Pesce, M., M. G. Farrace, M. Piacentini, S. Dolci et M. De Felici. « Stem cell factor and leukemia inhibitory factor promote primordial germ cell survival by suppressing programmed cell death (apoptosis) ». Development 118, n^o 4 (1 août 1993) : 1089–94. http://dx.doi.org/10.1242/dev.118.4.1089.

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Proliferating primordial germ cells (PGCs) isolated from mouse embryos soon after their arrival in the genital ridges would only survive in vitro at temperature of less than 30 degrees C (De Felici, M. and McLaren, A. (1983). Exp. Cell. Res. 144, 417–427; Wabik-Sliz, B. and McLaren, A. (1984). Exp. Cell. Res. 154, 530–536) or when co-cultured on cell feeder layers (Donovan, P. J., Stott, D., Godin, I., Heasman, J. and Wylie, C. C. (1986). Cell 44, 831–838; De Felici, M. and Dolci, S. (1991). Dev. Biol. 147, 281–284). In the present paper we report that mouse PGC death in vitro occurs with all the hallmarks of programmed cell death or apoptosis. We found that after 4–5 hours in culture many PGCs isolated from 12.5 dpc fetal gonads assumed a nuclear morphology and produced membrane bound fragments (apoptotic bodies) typical of apoptotic cells. In addition, PGCs in culture accumulated high level of tissue transglutaminase (tTGase; an enzyme that is induced and activated during apoptosis) and showed extensive degradation of DNA to oligonucleosomal fragments, which is characteristic of apoptosis. The physiological relevance of this mechanism of PGC death is supported by the finding that some PGCs undergoing apoptosis, as revealed by the high level of tTGase expression, were detected in the embryo. Most importantly, we show that the addition of stem cell factor (SCF) or leukemia inhibitory factor (LIF) to the culture medium, two cytokines known to favour PGC survival and/or proliferation in vitro, markedly reduced the occurrence of apoptosis in PGCs during the first hours in culture.(ABSTRACT TRUNCATED AT 250 WORDS)

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Patel, Pooja Nandwani, Rakesh Vyas et Maitrik Mehta. « Clinical implications of insulin-like growth factor I (IGF-I) and II (IGF-II) in stage IIIB cervical cancer. » Journal of Clinical Oncology 30, n^o 15_suppl (20 mai 2012) : e15505-e15505. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e15505.

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e15505 Background: The IGF (Insulin like Growth Factor) family has been implicated in the pathogenesis of cervical cancer. We aim to correlate pre and post treatment levels of IGF-I and IGF-II in stage IIIB cervical cancer and identify if serum IGF-I and IGF-II can be used as a marker to predict response to chemo-radiotherapy. Methods: We recruited 80 previously untreated patients of histopathologically proven squamous cell carcinoma of stage IIIB cancer of uterine cervix from January 2011 to May 2011. The age of patients ranged from 30 to 65 years and were of ECOG performance status of less than or equal to 2. Along with the routine investigations the pretreatment serum levels of IGF-I and IGF-II were done by ELISA kits in all the patients. The serum level of IGF-I was 246.3 ± 72.5 ng/ml and IGF-II was 1585 ± 352 ng/ml. All patients were given concurrent cisplatin (30 mg/m2) weekly along with radiation (50Gy/25#) with conventional portals followed by two sittings of intracavitory radiotherapy (7.5 Gy each) on mHDR. Blood samples for IGF-I and IGF-II levels were collected before the start of the therapy, 1 month after the completion of treatment and 6 months after the completion of the treatment. Results: The trend seen was that mean IGF-I levels were always in the lower range as compared to IGF-II levels in all individuals. The mean serum levels of IGF-I and IGF-II in patients who achieve complete response (45%) returned to normal whereas the mean serum levels of IGF-I and IGF-II in patients who achieved partial response (43%) was 149 ng/ml and 838 ng/ml respectively. The mean serum levels of IGF-I and IGF-II in patients who achieved no response (12%) was 331 ng/ml and 1840 ng/ml respectively. Conclusions: The serum levels of IGF-I and IGF-II may be a reliable prognostic and predictive marker in cervical cancer however further large randomized studies are required to validate the results. IGF-I and IGF-II can serve as potential markers in cervical cancer to risk stratify patients, assess treatment response and possibly act as therapeutic targets in the future.

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Vij, Ravi, Rajneesh Nath, Daniel E. H. Afar, María-Victoria Mateos, Jesús G. Berdeja, Marc S. Raab, Andreas Guenther et al. « First-in-Human Phase I Study of ABBV-838, an Antibody–Drug Conjugate Targeting SLAMF7/CS1 in Patients with Relapsed and Refractory Multiple Myeloma ». Clinical Cancer Research 26, n^o 10 (22 janvier 2020) : 2308–17. http://dx.doi.org/10.1158/1078-0432.ccr-19-1431.

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Yong, Su, Liu Suping, Zhang Peng, Lin Dong et Wei Qing. « The effects of vitamin C supplementation in the critically ill patients outcomes : A systematic review and meta-analysis of randomized controlled trials ». Medicine 103, n^o 12 (22 mars 2024) : e37420. http://dx.doi.org/10.1097/md.0000000000037420.

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Background: Vitamin C has significant anti-inflammatory effects and is particularly important for critically ill patients. However due to inconsistent research findings in critically ill patients in meta-analysis. Therefore, the primary objective of this meta-analysis is to investigate the effects of isolated intravenous supplementation of vitamin C in adults with critical illness by comprehensively incorporating articles from randomized controlled trials. Methods: Articles included searching through PubMed, Embase, Medline, Cochrane Library, and Web of Science up to April 28, 2023, for articles on vitamin C and the critically ill. We calculated pooled standard relative risk (RR), mean difference (MD), and 95% confidence intervals (CIs). And the protocol for the review has been registered on PROSPERO (CRD42023425193). Results: There are 2047 critically ill included in 19 articles. Compared with placebo, patients who underwent intravenous vitamin C (IVVC) have reduced duration of vasopressor used (SMD 0.26; CI 0.01–0.51; I 2 = 87.0%, P = .044), mechanical ventilation (SMD −0.29; CI −0.55 to −0.03; I 2 = 36.8%, P = .031). However, the administration of IVVC had no statistical difference in 28-d mortality (RR 0.95; CI 0.80–1.11; I 2 = 12.2%, P = .337), mortality (RR 0.79; CI 0.55–1.12; I 2 = 0%, P = .188), fluid intake (SMD −0.02; CI −0.25 to 0.20; I 2 = 0%, P = .838), urine output (SMD 0.23; CI −0.03 to 0.49; I 2 = 0%, P = .084), ICU days (SMD 0.10; CI −0.03 to 0.22; I 2 = 0%, P = .127), hospital stay (SMD 0.10; CI −0.12 to 0.32; I 2 = 0%, P = .375), and pneumonia (RR 0.85; CI 0.50–1.44; I 2 = 0%, P = .552). Conclusion: This study comprehensively and systematically evaluated IVVC supplementation in the critically ill through a meta-analysis of RCT. There is no difference except for patients who had reduced duration of vasopressor use and mechanical ventilation by the administration of IVVC. Of course. More scientific and rigorous conclusions can be drawn from multi-center RCT research in the future.

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Pich Mitjana, Josep, et David Martínez Fiol. « Manuel Brabo Portillo. Policía, espía y pistolero (1876-1919) ». Vínculos de Historia. Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, n^o 8 (20 juin 2019) : 387. http://dx.doi.org/10.18239/vdh_2019.08.20.

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RESUMEN:El objetivo del artículo es aproximarnos a la controvertida biografía del comisario Manuel Brabo Portillo. El trabajo está basado en fuentes primarias y secundarias. El método utilizado es empírico. En el imaginario del mundo sindicalista revolucionario, Brabo Portillo era el policía más odiado, la reencarnación de la cara más turbia del Estado. Fue, así mismo, un espía alemán relacionado con el hundimiento de barcos españoles, el asesinato del empresario e ingeniero Barret y el primer jefe de los terroristas vinculados a la patronal barcelonesa. La conflictividad que afectó a España en el período de la Primera Guerra Mundial es fundamental para entender los orígenes del terrorismo vinculado al pistolerismo, que marcó la historia político social española del primer tercio del siglo XX.PALABRAS CLAVE: Brabo Portillo, pistolerismo, espionaje, sindicalismo, Primera Guerra Mundial.ABSTRACT:The objective of the article is an approach to the controversial biography of Police Chief Manuel Brabo Portillo. The work is based on primary and secondary sources. The method used is empirical. In the imagery of the revolutionary syndicalist world, Brabo Portillo was the most hated policeman, the reincarnation of the murkiest face of the state. He was also a German spy connected with the sinking of Spanish ships, the murder of businessman and engineer Josep Barret and the first head of the terrorists linked to Barcelona employers. The conflict that affected Spain during the period of the First World War is fundamental in order to understand the origins of terrorism linked to pistolerismo, which marked Spanish social political history during the first third of the twentieth century.KEY WORDS: Brabo Portillo, pistolerismo, espionage, syndicalism, First World War. BIBLIOGRAFÍAAisa, M., La efervescencia social de los años 20. Barcelona 1917-1923, Barcelona, Descontrol, 2016.Aguirre de Cárcer, N., La neutralidad de España durante la Primera Guerra Mundial (1914-1918). I. Bélgica, Madrid, Ministerio de Asuntos Exteriores, 1995.Alonso, G., “’Afectos caprichosos’: Tradicionalismo y germanofilia en España durante la Gran Guerra”, Hispania Nova, 15, 2017, pp. 394-415.Amador, A., El Terror blanco en Barcelona. Las bombas y los atentados personales. Actuación infernal de una banda de asesinos al servicio de la burguesía. El asesinato como una industria, Tarragona, Talleres gráf. Gutenberg, [1920?].Anglés, C., “Contra los sindicatos. Los procesos de la organización obrera. La impostura nunca ha sido justicia”, Solidaridad Obrera, 836 (1/8/1918), p. 1.Balcells, A., El Pistolerisme. Barcelona (1917-1923), Barcelona, Pòrtic, 2009.Ben-Ami, S., La Dictadura de Primo de Rivera (1923-1930), Barcelona, Planeta, 1984.Bengoechea, S., Organització patronal i conflictivitat social a Catalunya. Tradició i corporativisme entre finals de segle i la dictadura de Primo de Rivera, Barcelona, PAM, 1994.Bengoechea, S., El locaut de Barcelona (1919-1920), Barcelona, Curial, 1998.Bengoechea, S., “1919: La Barcelona colpista. L’aliança de patrons i militars contra el sistema liberal”, Afers, 23/24 (1996), pp. 309-327.Brabo Portillo, M., Ensayo sobre policía científica, Barcelona, Gassó Hermanos, [190?].Bravo Portillo, M. y Samper, A., Programa para los exámenes de ingreso ó ascenso en plazas de oficiales de cuarta clase de la Hacienda Pública, Madrid, Mateu, 1906.Bueso, A., Recuerdos de un cenetista, Barcelona, Ariel, 1976.Burgos y Mazo, M. de, El verano de 1919 en Gobernación, Imprenta de E. Pinós-Cuenca, 1921.Calderón, F. de P. [Rico Ariza, E.] y Romero, I., Memorias de un terrorista. Novela episódica de la tragedia barcelonesa, Barcelona, [s.e.], [1924?].Carden, R. M., German Policy Toward Neutral Spain, 1914-1918, London, Routledge, 2014.Cardona, G., Los Milans del Bosch, una familia de armas tomar. Entre la revolución liberal y el franquismo, Barcelona, Edhasa, 2005.Casal Gómez, M., La Banda Negra. El origen y la actuación de los pistoleros en Barcelona (1918-1921), 2ª. Edición, Barcelona, Icaria, 1977.Calle Velasco, M. D. de la, “Sobre los orígenes del estado social en España”, Ayer, 25 (1997), pp. 127-150.D’Ors, E., “La unidad de Europa”, La Vanguardia, (1/12/1914), p. 7.Díaz Plaja, F., Francófilos y germanófilos. Los españoles en la guerra europea, Barcelona, Dopesa, 1973.Díez, P., Memorias de un anarcosindicalista de acción, Barcelona, Bellaterra, 2006.Domingo Méndez, R., “La Gran Guerra y la neutralidad española: entre la tradición historiográfica y las nuevas líneas de investigación”, Spagna Contemporanea, 34 (2008), pp. 27-44.Esculies, J., “España y la Gran Guerra. Nuevas aportaciones historiográficas”, Historia y Política, 32 (2014), pp. 47-70.Esdaile, Ch. J., La Quiebra del liberalismo, 1808-1939, Barcelona, Crítica, 2001.Foix, P., Los Archivos del terrorismo blanco. El fichero Lasarte (1910-1930), Madrid, Las Ediciones de la Piqueta, 1978.Forcadell, C., Parlamentarismo y bolchevización. El movimiento obrero español, 1914-1918, Barcelona, Crítica, 1978.Fuentes Codera, M., “El somni del retorn a l’Imperi: Eugeni d’Ors davant la Gran Guerra”, Recerques, 55 (2007), pp. 73-93.Fuentes Codera, M., “Germanófilos y neutralistas. Proyectos tradicionalistas y regeneracionistas para España (1914-1918)”, Ayer, 91/3 (2013), pp. 63-92.Fuentes Codera, M., España en la Primera Guerra Mundial. Una movilización cultural, Madrid, Akal, 2014.García Oliver, J., El Eco de los pasos, Paris/Barcelona, Ruedo Ibérico, 1978.García Sanz, F., España en la Gran Guerra, Madrid, Galaxia Gutenberg, 2014.Giráldez, E., “Brabo Portillo ¡Yo te acuso, Asesino!”, Solidaridad Obrera, 840 (5/8/1918), p. 1.Golden, L., “Les dones com avantguarda; El rebombori del pa del gener 1918”, L’Avenç (1981), pp. 45-52.Golden, L., “The women in command. The Barcelona women’s consumer war of 1918”, UCLA Historical Journal (1985), pp. 5-32.E. González Calleja y F. del Rey Reguillo, La Defensa armada contra la revolución. Una historia de las guardias cívicas en la España del siglo XX, Madrid, CSIC, 1995.González Calleja, E., La Razón de la fuerza. Orden público, subversión y violencia política en la España de la Restauración, 1875-1917, Madrid, CSIC, 1998.González Calleja, E., El Máuser y el sufragio. Orden público, subversión y violencia política en la crisis de la Restauración (1917-1931), Madrid, CSIC, 1999.González Calleja, E., (ed.), Políticas del miedo. Un balance del terrorismo en Europa, Madrid, Biblioteca Nueva, 2002.González Calleja, E., La España de Primo de Rivera. La modernización autoritaria 1923-1930, Madrid, Alianza Editorial, 2005.González Calleja, E., El laboratorio del miedo. Una historia general del terrorismo, Barcelona, Crítica, 2013.González Calleja, E. y Aubert, P., Nidos de espías. España, Francia y la Primera Guerra Mundial, Madrid, Alianza, 2014.González Calleja, E. (coord.), Anatomía de una crisis. 1917 y los españoles, Madrid, Alianza, 2017.Granados de Siles, J., “El escandaloso espionaje de Barcelona”, Solidaridad Obrera, 793 (19/6/1918), p. 1.Gual Villalbí, P., Memorias de un industrial de nuestro tiempo, Barcelona, Sociedad General de Publicaciones, [193?].León-Ignacio, J., Los años del pistolerismo. Ensayo para una guerra civil, Barcelona, Planeta, 1981.León-Ignacio, J., “Brabo Portillo, comisario y político”, Historia y vida, 181 (1983), pp. 68-73.Llates, R., 30 anys de vida catalana, Barcelona, Aedos, 1969.Madrid, F., Ocho meses y un día en el Gobierno Civil de Barcelona (confesiones y testimonios), Barcelona-Madrid, Las ediciones de la flecha, 1932.Manent, J., Records d’un sindicalista llibertari català, 1916-1943, París, Edicions Catalanes de París, 1976.Marquès, J., Història de l’organització sindical tèxtil “El Radium”, Barcelona, La Llar del Llibre, 1989.Márquez, B. y Capo, J. M., Las Juntas militares de defensa, Barcelona, Librería Sintes, 1923.Martínez Fiol, D., El catalanisme i la Gran Guerra (1914-1918). Antologia, Barcelona, La Magrana, 1988.Martínez Fiol, D. y Esculies Serrat, J., L’Assemblea de Parlamentaris de 1917 i la Catalunya rebel, Barcelona, Generalitat de Catalunya, 2017.Martínez Fiol, D. y Esculies Serrat, J., 1917. El año en que España pudo cambiar, Sevilla, Renacimiento, 2018.M.C.C., “El ‘affaire’ Brabo Portillo”, publicado en El Parlamentario y reproducido por Solidaridad Obrera, 926 (2/11/1918), p. 1.Mendoza, E., La verdad sobre el caso Savolta, Barcelona, Seix y Barral, 1975.Morales Lezcano, V., El colonialismo hispano-francés en Marruecos (1898-1927), Madrid, Siglo XXI, 1976.Navarra, A., 1914. Aliadófilos y germanófilos en la cultura española, Madrid, Cátedra, 2014.Navarra, A., Aliadòfils i germanòfils a Catalunya durant la Primera Guerra Mundial, Barcelona, Generalitat-CHCC, 2016.Nisk, “¡Inocente Brabo!”, Solidaridad Obrera, 789 (15/6/1918), p, 1.Pestaña, Á.,“A vuela pluma” y “En Libertad”, Solidaridad Obrera, 840-841 (5-6/8/1918), p. 1.Pestaña, Á., Terrorismo en Barcelona. Memorias inéditas, Barcelona, Planeta, [1979].Pradas Baena, M. A., L’anarquisme i les lluites socials a Barcelona 1918-1923. La repressió obrera i la violència, Barcelona, PAM, 2003.Pujadas, X., Marcel·lí Domingo i el marcel·linisme, [Barcelona], PAM, 1996.Roig, M., Rafael Vidiella. L’aventura de la revolució, Barcelona, Laia, 1976.Romero Salvadó, F. J., “Crisi, agonia i fi de la monarquía liberal (1914-1923)”, Segle XX. Revista catalana d’història, 1 (2008), pp. 57-82.Romero Salvadó, F. J. y Smith, A. (eds.), The Agony of Spanish Liberalism. FromRevolution to Dictatorship 1913-23, Houndmills, Basingstoke, Palgrave Macmillan, 2010.Rosenbusch, A., “Los servicios de información alemanes: sabotaje y actividad secreta”, Andalucía en la historia, 45 (2014), pp. 24-29.Rosenbusch, A., “Guerra Total en territorio neutral: Actividades alemanas en España durante la Primera Guerra Mundial”, Hispania Nova, 15 (2017), pp. 350-372.S. A., “Historia de un ‘bravo’ muy pillo”, La Campana de Gracia, 2569 (28/6/1918), p. 4.S.A., L’Esquella de la Torratxa, (12/7 y 30/8/ y 12/9/1918), pp. 447, 451, 456, 458, 568, 577 y 592.S. A., “A cada puerco le llega su San Martín” y “La muerte de Batet”, Solidaridad Obrera, 711 y 712 (9 y 10/1/1918), p. 1.S. A., Solidaridad Obrera, 713-716 (11-14/1/1918), p. 1.S. A., “Los conflictos del hambre”, Solidaridad Obrera, 717, 719-721 y 723-727 (15 y 17-19 y 21-25/1/1918), p. 1.S.A., Solidaridad Obrera, 783 y 784-786, (9-12/6/1918), p. 1.S.A., Solidaridad Obrera, 789-790, 794-795, 798 (15-16, 20-21 y 24/6/1918), p. 1.S. A., Solidaridad Obrera, 833 y 837 (28/7 y 2/8/1918), p. 1.S. A., Solidaridad Obrera, (3/7 y 12/12/1918), p. 2.S.A., “Veredicto popular”, Solidaridad Obrera, 790, 791, 793, 794, 795, 798, 799, 800, 802, 808, 809, 810, 811, 815, 816, 817, 818, 819, 820, 821, 822, 823, 825, 826, 827, 828, 829, 830, 832, 833, 834, 835, 836, 837, 838, 839 (16, 17, 19, 20, 21, 24, 25, 26, 28/6; 4, 5, 6, 7, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31/7; 1, 2, 3, 4/8/1918), pp. 1-3.S.A., “Envío a doña Remedios Montero de Brabo Portillo”, 871 (7/9/1918), p. 1.S.A., Solidaridad Obrera, (24, 25, 26, 27, 28 y 30/6 y 3, 6, 8, 5, 10, 12, 13 y 19/7, 4, 5, 9, 23, 24 y 26/8, 21, 24, 25, 31/10, 1, 2/11/ y 1-6, 8, 10, 11, 12, 14, 15, 20, 30 y 31/12/1918), pp. 1-4.Safont, J., Per França i Anglaterra. La I Guerra Mundial dels aliadòfils catalans, Barcelona, Acontravent, 2012.Sánchez Marín, A. L., “El Instituto de Reformas Sociales: origen, evolución y funcionamiento”, Revista Crítica de Historia de las Relaciones Laborales y de la Política Social, 8 (mayo 2014), pp. 7-28.Smith, A., “The Catalan Counter-revolutionary Coalition and the Primo de Rivera Coup, 1917–23”, European History Quaterly 37:1 (2007), pp. 7-34.Smith, A., Anarchism, revolution and reaction. Catalan labor and the crisis of the Spanish State, 1898-1923, New York, Oxford, Berghahn, 2007.Soldevilla, F., El Año político 1920, Madrid, I. de Julio Cosano, 1921.Taibo II, P. I., Que sean fuego las estrellas. Barcelona (1917-1923), Barcelona, Crítica, 2016.Tamames, R. y Casals, X., Miguel Primo de Rivera, Barcelona, Ediciones B, 2004.Tusell, J., Radiografía de un golpe de estado. El ascenso al poder del general Primo de Rivera, Madrid, Alianza, 1987.Val, R. del y Río del Val, J. del, Solidaridad Obrera, 787-788, 790, 794, 801, 805, 807, 811, 814, 818, 828, 829, 836, 970 (13, 14, 16, 20 y 27/6/, 3, 7, 10, 14, 23, 24 y 31/7/ y 1/8/ y 10/121918), p. 1.Vandellós, P., “Contra los sindicatos. Los procesos de la sindicación obrera. De actualidad”, Solidaridad Obrera, 791 (17/6/1918), p. 1.Vidiella, R., Los de ayer. Novela, Madrid-Barcelona, Nuestro Pueblo, 1938.Winston, C. M., La Clase trabajadora y la derecha en España (1900-1936), Madrid, Cátedra, 1989.Winston, C. M., “Carlist workers groups in Catalonia, 1900-1923”, en S. G. Payne (dir.), Identidad y nacionalismo en la España contemporánea: el carlismo, 1833-1975, Madrid, Actas, 1996, pp. 85-101.Wosky, Solidaridad Obrera, 791, 801 y 820, (17 y 21/6/ 10/7/1918), pp. 1 y 3.

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Billia, M., S. Pahernik, J. Relle, I. V. Popeneciu, T. Kuru, J. Hafron, C. Romagnoli, M. Burtnyk, H.-P. Schlemmer et J. L. Chin. « 838 Magnetic resonance imaging-guided transurethral ultrasound prostate ablation in patients with localized prostate cancer : 12-Month outcomes of a prospective phase I clinical trial ». European Urology Supplements 15, n^o 3 (mars 2016) : e838. http://dx.doi.org/10.1016/s1569-9056(16)60840-0.

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Sreekumar, AV, et Nishna Pradeep. « An in vitro Investigation into the Cytotoxicity of Methyl Methacrylate Monomer ». Journal of Contemporary Dental Practice 13, n^o 6 (2012) : 838–41. http://dx.doi.org/10.5005/jp-journals-10024-1239.

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ABSTRACT Aim of this study was to assess the cytotoxicity of monomer. An in vitro study was designed to study the growth inhibitory effect of monomer (Stellon, Denture Material Improved, Type I, Class I, Dental Products of India Limited) on cells seeded in petri dishes and maintained in an incubator with 5% carbon dioxide at 37°C. The growth of V79 cells (fibroblast cells) maintained in a culture medium to which monomer was added was studied for a period of 5 days. Results of this study pointed out that even at a concentration of 1 μl of monomer, the cell growth was significantly inhibited, when compared to the control group. The number of viable cells decreased dramatically whereas dead cells increased in the culture groups treated with the monomer. The cytotoxic effect was dose dependent. As the concentration increased from 1 to μl there was a marked inhibition of cell growth and a corresponding increase in dead cell count. Results of this study proved beyond doubt that monomer is indeed cytotoxic even in very low concentrations. Thus, it becomes imperative to adopt every possible means to minimize residual monomer content in heat cured resins. Also precautions to minimize tissue contact should be taken while handling monomer by the dentist and dental personnel in the laboratory. How to cite this article Pradeep N, Sreekumar AV. An in vitro Investigation into the Cytotoxicity of Methyl Methacrylate Monomer. J Contemp Dent Pract 2012;13(6):838-841.

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Taflin, Helena Anna, Karin M. E. Ganlov, Tormod Kyrre Guren, Christos Papadimitrou, Nikolaos K. Kentepozidis, Johan Haux, Per Pfeiffer et Goran Ulf Carlsson. « ISO-CC-005 : A phase I/II study of Modufolin (MTHF) in combination with 5-FU, irinotecan, and oxaliplatin ± bevacizumab in patients with metastasizing colorectal cancer. » Journal of Clinical Oncology 36, n^o 4_suppl (1 février 2018) : 838. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.838.

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838 Background: Chemotherapy treatment of Colorectal Cancer, often include 5-Fluorouracil (5- FU). 5-FU inhibits the enzyme thymidylate synthase (TS), stopping the supply of thymidine for DNA synthesis. 5-FU is always combined with a folate, which enhances the 5-FU effect. Marketed folates such as LV/L-LV are prodrugs needing enzymatic conversion. Modufolin is the natural, biologically active form of the folates and is expected to be efficacious in a larger proportion of patients with less inter- and intra-individual variability Methods: ISO-CC-005 is a multi-center, phase I/II study in mCRC patients eligible for 5-FU/folate therapy alone or in combination with irinotecan or oxaliplatin ± bevacizumab. The study investigates safety and tolerability of Modufolin at 4 dose levels by analysing the number and severity of AEs, SAEs and DLTs. Efficacy is evaluated as ORR after four cycles of chemotherapy. Gene expression, deoxyuridine levels as an indirect marker of TS inhibition and time to death is also investigated. Three to six patients per cohort are included. All receives Modufolin twice every two weeks during at least four cycles of chemotherapy. Results: Today, 42 patients have been enrolled and 40 have initiated treatment. 13 are 1st line patients, 16 are in 2nd line, 10 are in 3rd line and 1 is in 5th treatment line. 19 SAEs have been reported in 12 patients, 3 of these were judged as at least possibly related to Modufolin. No SAE were judged as solely related to Modufolin. 31 patients have today been evaluated for efficacy. ORR 1st line patients (n=12) All 50% (6 PR, 6 SD) Patients with Modufolin dose ≥60 mg/m2 71% (5 PR, 2 SD) Patients with Modufolin dose ≥60 mg/m2 + oxaliplatin 100% (3 PR) Conclusions: The lack of need for metabolic activation makes Modufolin a better candidate than LV/L-LV for improved outcome of 5-FU-based chemotherapy regimens in mCRC. The ISO-CC-005 study evaluates Modufolin in combination with 5-FU, irinotecan, oxaliplatin ± bevacizumab in mCRC patients in 4 countries in Europe. The results, so far, for both safety and efficacy seems promising. Clinical trial information: NCT02244632.

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Emig, G. « Chemilcal Reactor Design and Technology. Herausgeg. vonH. I. de Lasa. Martinus Nijhoff Publishers, Dordrecht - Boston - Lancaster 1986. XII, 838 S., zahlr. Abb. u. Tab., geb., £ 94,50 ». Chemie Ingenieur Technik 59, n^o 8 (août 1987) : 684. http://dx.doi.org/10.1002/cite.330590826.

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Bubnova, M. G., D. M. Aronov, R. G. Oganov et O. G. Rudomanov. « New potential of Trimetazidine MB for coronary heart disease treatment in the real-world clinical practice : results of the Russian multi-centre randomised study PERSPECTIVE (Part II) ». Cardiovascular Therapy and Prevention 10, n^o 6 (20 décembre 2011) : 70–80. http://dx.doi.org/10.15829/1728-8800-2011-6-70-80.

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Aim. As a clinical part of the Russian multi-centre randomised study, to assess the clinical benefits and safety of adding Trimetazidine MB to the standard treatment scheme in patients with stable angina (SA), in order to optimise their ambulatory therapy and improve their compliance. Material and methods. The study included 981 patients with Functional Class (FC) II-III SA and various concomitant diseases and syndromes, such as chronic heart failure (CHF), Type 2 diabetes mellitus (DM-2), or chronic obstructive pulmonary disease (COPD) in smokers. All participants were divided into two groups: Group I (n=838) received standard therapy plus trimetazidine MB (70 mg/d, twice a day), while Group II (n=143) received standard therapy only. The treatment and follow-up phases lasted for 12 months. Results. In Group I, the weekly number of angina attacks decreased by 42 % from the baseline at one month (р<0,0001), and by 70 % at 12 months (р<0,0001). The number of nitroglycerin (NTG) tablets taken decreased, respectively, by 41 % (р<0,0001) and 68 % (р<0,0001). In Group II, the decrease in angina attack number and NTG tablet number was significant only at 6 months and was less pronounced than in Group I. Therefore, in Group I, the number of patients with FC I increased by 7 times, while the number of FC III patients decreased by 1,8 times. No marked FC dynamics was observed in Group II. In Group I, left ventricular ejection fraction (LVEF) increased by 2,4 % (р<0,001), while interventricular septum and LV posterior wall thickness decreased, respectively, by 4,2 % (р<0,01) and 3,5 % (р<0,01). These parameters, however, did not change substantially in Group II patients. At 12 months, the number of patients hospitalised due to clinical decompensation, or becoming disable, was twice as high in Group II as in Group I. Conclusion. The Russian “PERSPECTIVE” Study results demonstrated high clinical effectiveness and safety ofTrimetazidineMB therapy, combined with standard treatment, in SA patients with CHF, DM-2, and COPD. Therefore, metabolic therapy could be more widely used in the real-world clinical settings.

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Basu, Patrick, Thankam Nair, Sakina Farhat, Sajith Foustin, Lynn P. Ang, Mikram Jafri, Kavya Mittimani, Ayesha A. Anwarullah et Niraj James Shah. « 838 Pegylated Interferon Alfa, Nitazoxanide, Telapravir, Ribavirin, in Genotype 1 Undergoing Prior Experienced Chronic Hepatitis C Patients-a Randomized Placebo Control Clinical Pilot Trial (I N T R I G U E C) Interim ». Gastroenterology 142, n^o 5 (mai 2012) : S—932. http://dx.doi.org/10.1016/s0016-5085(12)63615-4.

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Williams, Olamide. « A Monetary and Fiscal History of the United States, 1961–2021. By Alan S. Blinder. Princeton : Princeton University Press, 2022. 432 pp. Illustrations, index. Hardcover, $39.95. ISBN : 978-0-69123-838-8. » Business History Review 96, n^o 4 (2022) : 915–17. http://dx.doi.org/10.1017/s0007680522001039.

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Burnett, Charles. « Richard Goulet (ed.) : Dictionnairedes philosophes antiques, Vol. i : Abam(m)on à Axiothéa. 838 pp., front., 4 plates. Paris : Editions du Centre National de la Recherche Scientifique, 1989. » Bulletin of the School of Oriental and African Studies 54, n^o 1 (février 1991) : 234–35. http://dx.doi.org/10.1017/s0041977x00010478.

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Soon-Sinclair, Jan Mei, Samuel Imathiu, Adewale Olusegun Obadina, Fabrice Fabien Dongho Dongmo, Alex Dimitri Tchuenchieu Kamgain, Ennet Moholisa, Courage Kosi Setsoafia Saba, Abel Wilson Walekhwa, Henry Hunga et Jamal Kussaga. « How Worried Are You about Food Fraud ? A Preliminary Multi-Country Study among Consumers in Selected Sub-Saharan African Countries ». Foods 12, n^o 19 (29 septembre 2023) : 3627. http://dx.doi.org/10.3390/foods12193627.

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Food fraud is an old, recurring, and global threat to public health. It poses a serious threat to food security in sub-Saharan Africa (SSA). Despite the prevalence of food fraud in SSA, little is known about how food fraud is viewed by consumers. This study aims to provide an overview of consumers’ concerns about food fraud in SSA. A multi-country survey was conducted in October 2022–31 January 2023, and 838 valid responses were returned. To reduce the large and correlated dataset, Principal Component Analysis (PCA) was used. Five components were derived from PCA: (i) Staple foods; (ii) Premium food and drink products; (iii) Trust in reliable sources; (iv) Trust in less reliable sources; and (v) Trust in food vendors. The findings revealed Ghanaian (mean rank = 509.47) and Nigerian (mean rank = 454.82) consumers tended to score higher on the measure of food fraud concern suggesting that they were less confident in the safety and quality of the food they consume. Demographic characteristics including age, number of children, personal and family experience of food fraud and PCA components such as ‘Staple foods’, ‘Trust in reliable sources’, and ‘Trust in food vendors’ significantly predicted the model. This is the first preliminary study to provide empirical findings on consumers’ concerns about food fraud in SSA. Practical and policy recommendations for the region are suggested. This includes (i) modelling the AfriFoodinTegrity in West Africa across other major regions such as Central, East, and Southern Africa; (ii) establish a regional sub-Saharan Africa Rapid Alert System for Food and Feed (SSA-RASFF) platform; and (iii) food safety and food fraud reports could be incorporated into SSA-RASFF portal for information sharing.

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Hooi, Wai Foong, et John Waterston. « 048 Large pseudo-meningocele causing severe papilledema, retinal haemorrhages and recurrent positional syncope ». Journal of Neurology, Neurosurgery & ; Psychiatry 89, n^o 6 (24 mai 2018) : A20.2—A20. http://dx.doi.org/10.1136/jnnp-2018-anzan.47.

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IntroductionPseudo-meningocele is an abnormal collection of cerebrospinal fluid in the extradural space that occurs due to leakage from the CSF-filled spaces surrounding the brain and spinal cord. Pseudo-meningocele may result after spinal surgery. We report a case of a young woman with pseudo-meningocele post lumbar spinal surgery. She subsequently developed recurrent syncope, headaches and clinical signs of raised intracranial pressure (severe papilledema and retinal haemorrhages).CaseA 34 year old woman with spina bifida occulta and a large lipoma at the lumbar spinal level of L5 presented with urinary retention, worsening right leg pain, numbness and foot drop. She subsequently underwent L4-S1 laminectomy, debulking of lipoma and detethering of the cord. Her neurological deficits resolved post-surgery. One month later, the patient re-presented with recurrent syncope and intermittent headaches. She was admitted to the hospital for further investigations. Detailed neurological examination revealed grade IV papilledema and retinal haemorrhages. MRI of the brain showed distended optic nerve sheaths and narrowed distal transverse sinuses, in keeping with intracranial hypertension. MRI spine showed a large CSF collection posterior to the spinal canal at the L4-L5 level, measuring 77×53 mm in trans axial plane and 98 mm in craniocaudal dimension. Her symptoms improved with insertion of external ventricular drain. The symptoms resolved completely after a ventriculo-peritoneal shunt was inserted. She was commenced on acetazolamide. She remained well and asymptomatic. Repeat fundus photography a month later showed complete resolution of papilledema.ConclusionPostoperative pseudo-meningocele is uncommon and the exact incidence is unknown as most of these patients are asymptomatic. This case illustrates that pseudo-meningocele can cause raised intracranial pressure leading to recurrent syncope. It is important for clinician to recognise the varied clinical presentations of meningocele and pseudo-meningocele.References. Marlin A, Epstein F, Rovid R. Positional headache and syncope associated with a pseudomeningocele. Arch Neurol1980;37(11):736–737.. Bekavac I, Hollaran J. Meningocele-induced positional syncope and retinal haemorrhages. AJNR Am J NeuroradiolMay 2003;24:838–839.. Arseni C, Maretsis M. Tumours of the lower spinal cord associated with increased intracranial pressure and papilloedema. J Neurosurg1967;27:105–110.

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Bartell, Eric, Masanobu Fujimoto, Jane C. Khoury, Philip R. Khoury, Sailaja Vedantam, Christina M. Astley, Joel N. Hirschhorn et Andrew Dauber. « Protein QTL analysis of IGF-I and its binding proteins provides insights into growth biology ». Human Molecular Genetics 29, n^o 15 (1 juin 2020) : 2625–36. http://dx.doi.org/10.1093/hmg/ddaa103.

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Abstract The growth hormone and insulin-like growth factor (IGF) system is integral to human growth. Genome-wide association studies (GWAS) have identified variants associated with height and located near the genes in this pathway. However, mechanisms underlying these genetic associations are not understood. To investigate the regulation of the genes in this pathway and mechanisms by which regulation could affect growth, we performed GWAS of measured serum protein levels of IGF-I, IGF binding protein-3 (IGFBP-3), pregnancy-associated plasma protein A (PAPP-A2), IGF-II and IGFBP-5 in 838 children (3–18 years) from the Cincinnati Genomic Control Cohort. We identified variants associated with protein levels near IGFBP3 and IGFBP5 genes, which contain multiple signals of association with height and other skeletal growth phenotypes. Surprisingly, variants that associate with protein levels at these two loci do not colocalize with height associations, confirmed through conditional analysis. Rather, the IGFBP3 signal (associated with total IGFBP-3 and IGF-II levels) colocalizes with an association with sitting height ratio (SHR); the IGFBP5 signal (associated with IGFBP-5 levels) colocalizes with birth weight. Indeed, height-associated single nucleotide polymorphisms near genes encoding other proteins in this pathway are not associated with serum levels, possibly excluding PAPP-A2. Mendelian randomization supports a stronger causal relationship of measured serum levels with SHR (for IGFBP-3) and birth weight (for IGFBP-5) than with height. In conclusion, we begin to characterize the genetic regulation of serum levels of IGF-related proteins in childhood. Furthermore, our data strongly suggest the existence of growth-regulating mechanisms acting through IGF-related genes in ways that are not reflected in measured serum levels of the corresponding proteins.

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Türkoğlu, Abdurrahim, Mehmet Tokdemir, Ferhat Turgut Tunçez, Turgay Börk, Burhan Yaprak et Mustafa Şen. « Elazığ’da 2010-2012 Yılları Arasında Otopsisi Yapılan Ateşli Silahlara Bağlı Ölümlerin Değerlendirilmesi ». Bulletin of Legal Medicine 17, n^o 3 (24 avril 2014) : 8–14. http://dx.doi.org/10.17986/blm.201217311.

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Dünyada ve ülkemizde ateşli silahlar nedeniyle ölüm oranı gün geçtikçe artmaktadır. Tüm medikolegal ölümler göz önüne alındığında ateşli silah ile ölümler önemli bir oran oluşturmaktadır. Çalışmamızda ateşli silah ile meydana gelen ölüm olgularının genel özelliklerinin belirlenmesi ve benzer çalışmalarla karşılaştırılma yapılması amaçlanmıştır. Elazığ’da Fırat Üniversitesi Hastanesi Adli Tıp Anabilim Dalı’nda 2010-2012 yıllarında ölü muayenesi ve otopsisi yapılan 838 olgudan ateşli silah sonucu öldüğü tespit edilen 120 (%14.3) olgu retrospektif olarak incelendi. Bu olgular yaş, cinsiyet, orijin, kullanılan silah türü, atış mesafesi, giriş sayısı, yara lokalizasyonu, olay yeri ve olayın meydana geldiği zaman parametrelerine göre değerlendirildi. Olguların 102’si (%85) erkek 18’i (%15) kadın, en küçüğü 9, en büyüğü 86 yaşında olup yaş ortalaması 31.58±14.34’dir. Ölümlerin en sık 20-29 yaş grubunda (%45.8), mayıs ayında (%14.2) ve yaz mevsiminde (%30.8) olduğu görüldü. Orijin olarak en sık terör çatışması (%32.2) ve intihar (%32.2) görülürken bunu cinayet (%27.3) ve kaza sonucu ölüm izlemektedir. Olguların 81’inde (%66.1) tek giriş deliği olduğu ve ölümlerin en sık baş-boyun bölgesinden (%37.5) yaralanma sonucu oluştuğu görüldü.Ateşli silahlar ile ölümler; bölgemizde meydana gelen adli ölümlerin önemli bir kısmını oluşturmaktadır. Dünya ve Türkiye verileriyle karşılaştırıldığında terör ve sosyokültürel özellikler gibi bölgesel faktörlere bağlı farklılıklar görülmektedir. Ateşli silahlarla ölüm oranının azaltılması için ruhsatsız silah kullanımının önlenmesi, silah ruhsatı verilmeden önce tıbbı muayene ve ruhsat verme kriterlerine daha fazla dikkat edilmesi, ayrıca bu konularda toplumun eğitilmesi gerektiği kanısındayız.Anahtar kelimeler: Ateşli silah yaralanması, otopsi, intihar

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Wan Mei Qi et Mohd Norazmi bin Nordin. « TEACHERS' KNOWLEDGE LEVEL OF EMOTIONAL DISTURBANCE AND REGULATION OF STUDENTS WITH SPECIAL EDUCATION NEEDS ». Special Education [SE] 1, n^o 1 (21 février 2023) : e0007. http://dx.doi.org/10.59055/se.v1i1.7.

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Emotional disturbance and regulation are key elements in special education classes but are still understudied. This study explores the topic of the emotions of students with special educational needs (SEN). The objective of this study is to examine the level of special education teachers' knowledge of (i) emotional disturbance and (ii) emotional regulation in SEN students. This study uses a quantitative approach in the form of survey as research design. A total of 74 primary school special education teachers were involved as respondents through a simple random sampling technique. Instrument used is a questionnaire adapted from the Emotion Regulation Skills Questionnaire by Mirabile (2014). Cronbach's Alpha validity obtained for the instrument after adaptation and pilot study was .838. Data was collected by distributing online questionnaire to the population of primary special education teachers through social media. Descriptive analysis was conducted on collected data through Statistical Package for Social Sciences (SPSS) software and summarized in table form. The findings of this study show a high level of special education teachers' knowledge of emotional disturbance in SEN students (mean=3.56) while teachers' knowledge of emotional regulation in SEN students recorded a moderate level (mean=2.94). Special education teachers have basic knowledge of emotions in SEN students but yet to reach the optimal level. The planning and implementation of learning in special education classes needs to emphasize the importance of regulating students' emotions and the role of teachers in emotions coregulations with SEN students.

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Malone, Linda A. « Philippe Sands, Principles of International Environmental Law (Manchester University Press, 1995) (Philippe Sands, Richard Tarasofsky, & ; Mary Weiss, eds.) Vol. I, 754 pages ; Vol. II, 1709 pages ; Vol. III, 838 pages ». Yearbook of International Environmental Law 6, n^o 1 (1995) : 732–33. http://dx.doi.org/10.1093/yiel/6.1.732.

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Laudin, Gérard, et Anguélina Vatcheva. « La Russie et la Méditerranée. L’Expédition à l’Archipélague de Catherine la Grande ( Rossia i Sredizemnomorie. Archipelagskaya ekspeditsija Ekateriny Velikoï ), dir. Irina Smilyanskya Mikhaïl Velizhev, Elena Smilyanskya, Moscou, Indrik, 2011, 838 p. » Dix-huitième siècle 47, n^o 1 (17 juin 2015) : XCVIII. http://dx.doi.org/10.3917/dhs.047.0627ct.

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Talbot, Michael S., Joel R. Brownstein, Kyle S. Dawson, Jean-Paul Kneib et Julian Bautista. « The completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey : a catalogue of strong galaxy–galaxy lens candidates ». Monthly Notices of the Royal Astronomical Society 502, n^o 3 (1 février 2021) : 4617–40. http://dx.doi.org/10.1093/mnras/stab267.

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ABSTRACT We spectroscopically detected 838 likely, 448 probable, and 265 possible strong lens candidates within ≈2 million galaxy spectra contained within the extended Baryon Oscillation Spectroscopic Survey (eBOSS) from the sixteenth data release (DR16) of the Sloan Digital Sky Survey (SDSS). We apply the spectroscopic detection method of the Baryon Oscillation Spectroscopic Survey (BOSS) Emission-Line Lens Survey (BELLS) and add Gaussian fit information, grading, additional inspection observables, and additional inspection methods to improve our selection method. We observed 477 candidates with lensing evidence within low-resolution images from both the Legacy survey of SDSS-I/II and the DESI Legacy survey, which is $12{{\ \rm per\ cent}}$ higher than the percentage of BELLS candidates observed with similar lensing evidence. Our search within the latest and improved reductions of the BOSS survey yielded a $20{{\ \rm per\ cent}}$ increase in the number of lens candidates expected from searching all BOSS and eBOSS galaxies. The distribution of target and background redshifts of our candidates is similar to the candidates and confirmed lenses within the BELLS observations. We present our Spectroscopic Identification of Lensing Object candidates in a value-added catalogue in SDSS DR16. The examination of these lens candidates in follow-up high-resolution imaging may yield more than twice the lenses found in previous spectroscopic detection surveys within SDSS, which would extend the results of previous lens surveys within SDSS to higher redshifts, constrain models of mass structures in spiral galaxies, and test if including the identification of possible lensing features within low-resolution images has merit to spectroscopic detection programmes.

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Hennessy, D. W., et S. G. Morris. « Effect of a preweaning growth restriction on the subsequent growth andmeat quality of yearling steers and heifers ». Australian Journal of Experimental Agriculture 43, n^o 4 (2003) : 335. http://dx.doi.org/10.1071/ea02072.

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The eating quality of 3 'cuts' of meat was assessed on carcasses of steers (n = 46) and heifers (n = 33) when slaughtered at 17 months of age, following preweaning growth restriction. Growth restriction (for 115 days to weaning) was imposed on half the group ('low'; n = 39 steers and heifers), followed by 2 periods of high-quality nutrition for all animals on (i) pastures (180 days) and (ii) on a grain diet in a feedlot (85 days). Preweaning growth rates (mean and standard error of difference) of steers and heifers on the 'high' treatment (905 v. 838 ± 35.0 g/day) were effectively halved (498 v. 434 ± 35.0 g/day) in the restricted 'low' group. However, no significant compensatory growth occurred when these weight-restricted weaners grazed high-quality pastures, nor during their period in the feedlot. At slaughter, the predicted liveweight of 'high'-growth steers was higher than that of 'low'-growth steers (477 v. 416 ± 11.5 kg) and they had a heavier carcass weight (251 v. 221 ± 7.2 kg). There was no difference between the meat quality (MQ4) scores of meat samples from 'low' or 'high' carcasses in which cuts of blade (2302 'bolar blade', AUS-MEAT 1998) scored higher than rump (2110 'rostbiff', AUS-MEAT 1998) and striploin (2140 striploin, AUS-MEAT 1998) samples. The study has highlighted the persistent effect of undernutrition in early life on final liveweights of Hereford cattle and the consequent reduction in their carcass weight. However, there was no carryover effect of early nutrition on meat quality.

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Ekanayaka, Pathum, Seo-Yong Lee, Thilina U. B. Herath, Jae-Hoon Kim, Tae-Hwan Kim, Hyuncheol Lee, Kiramage Chathuranga, W. A. Gayan Chathuranga, Jong-Hyeon Park et Jong-Soo Lee. « Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation ». PLOS Pathogens 16, n^o 11 (24 novembre 2020) : e1009057. http://dx.doi.org/10.1371/journal.ppat.1009057.

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VP1, a pivotal capsid protein encoded by the foot-and-mouth disease virus (FMDV), plays an important role in receptor-mediated attachment and humoral immune responses. Previous studies show that amino acid changes in the VP1 protein of cell culture-adapted strains of FMDV alter the properties of the virus. In addition, FMDV VP1 modulates host IFN signal transduction. Here, we examined the ability of cell culture-adapted FMDV VP1(83K) and wild-type FMDV VP1(83E) to evade host immunity by blocking mitochondrial antiviral signaling protein (MAVS)/TNF Receptor Associated Factor 3 (TRAF3) mediated cellular innate responses. Wild-type FMDV VP1(83E) interacted specifically with C-terminal TRAF3-binding site within MAVS and this interaction inhibited binding of TRAF3 to MAVS, thereby suppressing interferon-mediated responses. This was not observed for cell culture-adapted FMDV VP1(83K). Finally, chimeric FMDV harboring VP1(83K) showed very low pathogenicity in pigs. Collectively, these data highlight a critical role of VP1 with respect to suppression of type-I IFN pathway and attenuation of FMDV by the E83K mutation in VP1.

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Jerkovic, Zlatko, Toni Modric et Sime Versic. « Analysis of the Associations between Contextual Variables and Match Running Performance in Croatian First Division Soccer ». Sport Mont 20, n^o 2 (1 juin 2022) : 125–30. http://dx.doi.org/10.26773/smj.220619.

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It has been hypothesized that contextual variables (i.e. match location, opponents’ level) could be important deter- minants of running performance (RP) in soccer matches, but empirical studies provided inconsistent evidences. This study aimed to investigate the associations between contextual variables (CV) and RP in Croatian soccer players. Players’ RP (n=193) were evaluated, and used as cases in this study. CV included match outcome (win-draw-loss), opponent’s level (higher vs. lower ranked), and match location (home-away). RP were measured by global position- ing system during the soccer matches in seasons 2018/19 (n=14) and 2019/20 (n=15) of Croatian first division, and included: the total distance covered, low-intensity (<14.3 km/h), running (14.4–19.7 km/h), high-intensity running (>19.8 km/h), high-speed running (19.8–25.1 km/h) and sprinting (>25.2 km/h). Results indicated significantly great- er amount of distance covered in running zone for away matches (F-test: 7.83, p<0.01, small effect size; 1392±353 m and 1262±294 m, for home and away matches, respectively). Similar RP were observed irrespective of opponents’ level (F-test: 0.05 to 1.53, p>0.05). Lowest total-, low- and running-zone distances were evidenced in won matches (9893±896 m, 8035±614 m and 1241±312 m, respectively), followed by drawn matches (10298±913 m, 8287±838 m and 1363±320 m, respectively) and lost matches (10355±1052 m, 8279±742 m and 1406±343 m, respectively). This study demonstrated that (i) won matches were characterized by lower RP, (ii) association between RP and match location was limited, (iii) RP was not related to the opponents’ level.

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