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Littérature scientifique sur le sujet « HYOU1 »

Auteur : Grafiati

Publié le 1 février 2025

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Articles de revues sur le sujet "HYOU1"

Rao, Shan, Linda Oyang, Jiaxin Liang, Pin Yi, Yaqian Han, Xia Luo, Longzheng Xia et al. « Biological Function of HYOU1 in Tumors and Other Diseases ». OncoTargets and Therapy Volume 14 (mars 2021) : 1727–35. http://dx.doi.org/10.2147/ott.s297332.

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Hao, Aixin, Yu Wang, Xiao Zhang, Jialiang Li, Yingzhou Li, Dangdang Li, George Kulik et Guangchao Sui. « Long non-coding antisense RNA HYOU1-AS is essential to human breast cancer development through competitive binding hnRNPA1 to promote HYOU1 expression ». Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868, n^o 4 (avril 2021) : 118951. http://dx.doi.org/10.1016/j.bbamcr.2021.118951.

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Liu, Kaiqiang, Xiancai Hao, Qian Wang, Jilun Hou, Xiaofang Lai, Zhiguo Dong et Changwei Shao. « Genome-wide identification and characterization of heat shock protein family 70 provides insight into its divergent functions on immune response and development of Paralichthys olivaceus ». PeerJ 7 (11 novembre 2019) : e7781. http://dx.doi.org/10.7717/peerj.7781.

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Flatfish undergo extreme morphological development and settle to a benthic in the adult stage, and are likely to be more susceptible to environmental stress. Heat shock proteins 70 (hsp70) are involved in embryonic development and stress response in metazoan animals. However, the evolutionary history and functions of hsp70 in flatfish are poorly understood. Here, we identified 15 hsp70 genes in the genome of Japanese flounder (Paralichthys olivaceus), a flatfish endemic to northwestern Pacific Ocean. Gene structure and motifs of the Japanese flounder hsp70 were conserved, and there were few structure variants compared to other fish species. We constructed a maximum likelihood tree to understand the evolutionary relationship of the hsp70 genes among surveyed fish. Selection pressure analysis suggested that four genes, hspa4l, hspa9, hspa13, and hyou1, showed signs of positive selection. We then extracted transcriptome data on the Japanese flounder with Edwardsiella tarda to induce stress, and found that hspa9, hspa12b, hspa4l, hspa13, and hyou1 were highly expressed, likely to protect cells from stress. Interestingly, expression patterns of hsp70 genes were divergent in different developmental stages of the Japanese flounder. We found that at least one hsp70 gene was always highly expressed at various stages of embryonic development of the Japanese flounder, thereby indicating that hsp70 genes were constitutively expressed in the Japanese flounder. Our findings provide basic and useful resources to better understand hsp70 genes in flatfish.

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Sargiacomo, Camillo, et Aleksandr Klepinin. « Density Gradient Centrifugation is an Effective Tool to Isolate Cancer Stem-Like Cells from Hypoxic and Normoxia Triple-Negative Breast Cancer Models ». International Journal of Molecular Sciences 25, n^o 16 (17 août 2024) : 8958. http://dx.doi.org/10.3390/ijms25168958.

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Accumulating evidence has indicated that stemness-related genes are associated with the aggressiveness of triple-negative breast cancer (TNBC). Because no universal markers for breast CSCs are available, we applied the density gradient centrifugation method to enrich breast CSCs. We demonstrated that the density centrifugation method allows for the isolation of cancer stem cells (CSCs) from adherent and non-adherent MCF7 (Luminal A), MDA-MB-231 (TNBC) and MDA-MB-468 (TNBC) breast cancer cells. The current study shows that the CSCs’ enriched fraction from Luminal A and TNBC cells have an increased capacity to grow anchorage-independently. CSCs from adherent TNBC are mainly characterized by metabolic plasticity, whereas CSCs from Luminal A have an increased mitochondrial capacity. Moreover, we found that non-adherent growth CSCs isolated from large mammospheres have a higher ability to grow anchorage-independently compared to CSCs isolated from small mammospheres. In CSCs, a metabolic shift towards glycolysis was observed due to the hypoxic environment of the large mammosphere. Using a bioinformatic analysis, we indicate that hypoxia HYOU1 gene overexpression is associated with the aggressiveness, metastasis and poor prognosis of TNBC. An in vitro study demonstrated that HYOU1 overexpression increases breast cancer cells’ stemness and hyperactivates their metabolic activity. In conclusion, we show that density gradient centrifugation is a non-marker-based approach to isolate metabolically flexible (normoxia) CSCs and glycolytic (hypoxic) CSCs from aggressive TNBC.

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Yuan, Tao, Hong Qian, Xin Yu, Jia Meng, Cheng-Teng Lai, Hui Jiang, Jian-Ning Zhao et Ni-Rong Bao. « Proteomic analysis reveals rotator cuff injury caused by oxidative stress ». Therapeutic Advances in Chronic Disease 12 (janvier 2021) : 204062232098705. http://dx.doi.org/10.1177/2040622320987057.

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Background and aims: Rotator cuff tendinopathy is common and is related to pain and dysfunction. However, the pathological mechanism of rotator cuff injury and shoulder pain is unclear. Objective: to investigate the pathological mechanism of rotator cuff injury and shoulder pain, and screen out the marker proteins related to rotator cuff injury by proteomics. Methods: Subacromial synovium specimens were collected from patients undergoing shoulder arthroscopic surgery. The experimental group were patients with rotator cuff repair surgery, and the control group were patients with habitual dislocation of the shoulder joint. Pathological examination was performed, and then followed by non-labeled quantitative proteomic detection. Finally, from analysis of the biological information of the samples, specific proteins related to rotator cuff injury and shoulder pain were deduced by functional analysis of differential proteins. Results: All the patients in experimental groups were representative. A large number of adipocytes and inflammatory cells were found in the pathological sections of the experimental group; the proteomics analysis screen identified 80 proteins with significant differences, and the analysis of protein function revealed that S100A11 ( p = 0.011), PLIN4 ( p = 0.017), HYOU1 ( p = 0.002) and CLIC1 ( p = 0.007) were closely related to oxidative stress and chronic inflammation. Conclusion: Rotator cuff injury is closely related to oxidative stress and chronic inflammatory response, and the results suggest that the expression of S100A11, PLIN4, HYOU1 and CLIC1 in the synovium of rotator cuff injury provides a new marker for the study of its pathological mechanism.

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Wu, Yujia, Zhenlin Wu, Qiying Jin, Jinyuan Liu et Peiping Xu. « Identification and Analysis of Biomarkers Associated with Lipophagy and Therapeutic Agents for COVID-19 ». Viruses 16, n^o 6 (7 juin 2024) : 923. http://dx.doi.org/10.3390/v16060923.

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Background: Lipids, as a fundamental cell component, play an regulating role in controlling the different cellular biological processes involved in viral infections. A notable feature of coronavirus disease 2019 (COVID-19) is impaired lipid metabolism. The function of lipophagy-related genes in COVID-19 is unknown. The present study aimed to investigate biomarkers and drug targets associated with lipophagy and lipophagy-based therapeutic agents for COVID-19 through bioinformatics analysis. Methods: Lipophagy-related biomarkers for COVID-19 were identified using machine learning algorithms such as random forest, Support Vector Machine-Recursive Feature Elimination, Generalized Linear Model, and Extreme Gradient Boosting in three COVID-19-associated GEO datasets: scRNA-seq (GSE145926) and bulk RNA-seq (GSE183533 and GSE190496). The cMAP database was searched for potential COVID-19 medications. Results: The lipophagy pathway was downregulated, and the lipid droplet formation pathway was upregulated, resulting in impaired lipid metabolism. Seven lipophagy-related genes, including ACADVL, HYOU1, DAP, AUP1, PRXAB2, LSS, and PLIN2, were used as biomarkers and drug targets for COVID-19. Moreover, lipophagy may play a role in COVID-19 pathogenesis. As prospective drugs for treating COVID-19, seven potential downregulators (phenoxybenzamine, helveticoside, lanatoside C, geldanamycin, loperamide, pioglitazone, and trichostatin A) were discovered. These medication candidates showed remarkable binding energies against the seven biomarkers. Conclusions: The lipophagy-related genes ACADVL, HYOU1, DAP, AUP1, PRXAB2, LSS, and PLIN2 can be used as biomarkers and drug targets for COVID-19. Seven potential downregulators of these seven biomarkers may have therapeutic effects for treating COVID-19.

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Wang, Jia‐Mei, Jing‐Yi Jiang, Da‐Lin Zhang, Xin Du, Tong Wu et Zhen‐Xian Du. « HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA ». Journal of Cellular and Molecular Medicine 25, n^o 10 (31 mars 2021) : 4814–25. http://dx.doi.org/10.1111/jcmm.16453.

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Zhou, Yujuan, Qianjin Liao, Xiayu Li, Hui Wang, Fang Wei, Jie Chen, Jing Yang et al. « HYOU1, Regulated by LPLUNC1, Is Up-Regulated in Nasopharyngeal Carcinoma and Associated with Poor Prognosis ». Journal of Cancer 7, n^o 4 (2016) : 367–76. http://dx.doi.org/10.7150/jca.13695.

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An, Meng, Xiaowen Zang, Jimin Wang, Jie Kang, Xiaoyu Tan et Bo Fu. « Comprehensive analysis of differentially expressed long noncoding RNAs, miRNAs and mRNAs in breast cancer brain metastasis ». Epigenomics 13, n^o 14 (juillet 2021) : 1113–28. http://dx.doi.org/10.2217/epi-2021-0152.

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Aim: To delineate the transcriptomic landscape and potential molecular mechanisms of breast cancer brain metastasis (BCBM). Materials & methods: Whole-transcriptome sequencing was performed to identify long noncoding RNA (lncRNA), miRNA and mRNA expression profiles associated with BCBM. Results: A total of 739 differentially expressed lncRNAs, 115 differentially expressed miRNAs and 5749 differentially expressed mRNAs were identified in 231-BR cells compared with MDA-MB-231 cells. Real-time quantitative PCR results revealed the expression levels of candidate molecules were consistent with their correspondence RNA-seq data. Protein–protein interaction analysis identified some hub genes associated with BCBM, such as PTBP1, NUP98 and HYOU1. LncRNA-miRNA-mRNA network highlighted a potential mechanism of BCBM in which lncRNA FIRRE and RP11-169F17.1 sponging hsa-miR-501-5p to regulate the expression of MMS19, PTBP1 and NUP98. Conclusion: This study provides a framework for better understanding molecular mechanisms of BCBM.

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Wang, Zhe, Chen Tan, Caihan Duan, Junhao Wu, Dan Zhou, Lingzhi Hou, Wei Qian, Chaoqun Han et Xiaohua Hou. « FUT2-dependent fucosylation of HYOU1 protects intestinal stem cells against inflammatory injury by regulating unfolded protein response ». Redox Biology 60 (avril 2023) : 102618. http://dx.doi.org/10.1016/j.redox.2023.102618.

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Thèses sur le sujet "HYOU1"

Idani, Aida. « A multiomics approach to primary immunodeficiencies in human ». Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ061.

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Les déficits immunitaires primitifs sont un groupe de troubles causés par des mutations monogéniques dans des gènes jouant un rôle clé dans le développement et la fonction du système immunitaire. Dans cette thèse, une approche multiomique a été adoptée pour étudier deux gènes associés à ces conditions, afin d'élucider davantage les mécanismes par lesquels les variants pathogènes nuisent au système immunitaire. Le premier sujet était HYOU1, défini comme un gène dont les défauts causent un déficit immunitaire primitif. Nous avons observé une hypogranularité dans les neutrophiles du patient et révélé un arrêt de maturation dans la lignée des cellules B avant le stade des cellules B pro. Le deuxième sujet était ITGAL, un gène candidat potentiel non précédemment décrit en relation avec les déficits immunitaires primitifs. Nous avons démontré que le variant étudié est hérité selon un mode autosomique récessif, et les analyses de voies ont révélé un dysfonctionnement de plusieurs voies liées à l'adhésion et à la motilité. De plus, nous avons montré une élévation de l'expression d'autres intégrines, suggérant une réponse compensatoire visant à contrebalancer les intégrines défectueuses
Primary immunodeficiencies, or inborn errors of immunity, are a group of disorders caused by monogenic mutations in genes playing a key role in the development and function of the immune system. In this thesis, a multiomics approach was taken to study two genes associated with these conditions, further elucidating the mechanisms by which pathogenic variants impair the immune system. The first subject was HYOU1, defined as a gene whose defects cause primary immunodeficiency. We observed hypogranularity in the patient's neutrophils and revealed a maturation arrest in the B cell lineage before the pro-B cell stage. The second subject was ITGAL, a potential candidate gene not previously described in relation to primary immunodeficiencies. We demonstrated that the studied variant is inherited in an autosomal recessive pattern, and pathway analyses revealed impairment of multiple adhesion and motility-related pathways. Moreover, we showed an elevation in the expression of other integrins, suggesting a compensatory response to counterbalance the defective integrins

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Kang, Ji Hyoun [Verfasser]. « Phylogenetic and Molecular Investigations of the Evolutionary Novelties, Sword and Gonopodium, in the Swordtail Fish (the genus Xiphophorus) / Ji Hyoun Kang ». Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1081016493/34.

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Seo, Hyesook [Verfasser]. « Weibliche Figuren und ihre Rollen in ausgewählten Werken Heinrich Bölls / vorgelegt von Hyesook Seo, geb. Hyoun ». 2007. http://d-nb.info/987453262/34.

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Livres sur le sujet "HYOU1"

Simsan No Su-hyon = : Ro, Su-Hyoun (Simsan). Ol kwa Al, 2000.

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Chapitres de livres sur le sujet "HYOU1"

Han, Chao, et Fengtong Wen. « Certificateless Identity Management and Authentication Scheme Based on Blockchain Technology ». Dans Proceeding of 2021 International Conference on Wireless Communications, Networking and Applications, 1077–88. Singapore : Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-2456-9_108.

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AbstractIdentity management and authentication in cyberspace is crucial for all forms of remote communication. The traditional authentication technology has great security risks due to its central third-party structure, such as single point of failure, malicious server attacks and so on. The emergence of blockchain technology provides a new way of thinking to solve this problem. This paper focuses on the identity management and authentication scheme based on blockchain technology. Using the decentralized, open and transparent characteristics of blockchain to make up for the shortcomings of traditional identity management and authentication mechanisms. In this paper, we analyze the BIDaaS [1] identity management and authentication scheme proposed by Jong-Hyouk and point out the obvious shortcomings of the scheme, such as suffer impersonating attack simply, virtual identities are not unique. We combine the specificity of biological characteristics to implement a unique virtual identity on the chain and improve the off-chain identity authentication process using a certificateless scheme to build a reasonable and secure identity management and authentication scheme, which realizes two-way authentication and session key agreement. The analysis shows that the scheme has a high level of safety.

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