Bibliographies thématiques / Hydroxypipecolic acids

Littérature scientifique sur le sujet « Hydroxypipecolic acids »

Auteur : Grafiati

Publié le 10 mars 2023

Créez une référence correcte selon les styles APA, MLA, Chicago, Harvard et plusieurs autres

Choisissez une source :

Sommaire

Articles de revues
Thèses
Actes de conférences

Consultez les listes thématiques d’articles de revues, de livres, de thèses, de rapports de conférences et d’autres sources académiques sur le sujet « Hydroxypipecolic acids ».

À côté de chaque source dans la liste de références il y a un bouton « Ajouter à la bibliographie ». Cliquez sur ce bouton, et nous générerons automatiquement la référence bibliographique pour la source choisie selon votre style de citation préféré : APA, MLA, Harvard, Vancouver, Chicago, etc.

Vous pouvez aussi télécharger le texte intégral de la publication scolaire au format pdf et consulter son résumé en ligne lorsque ces informations sont inclues dans les métadonnées.

Articles de revues sur le sujet "Hydroxypipecolic acids"

Cochi, Anne, Domingo Gomez Pardo et Janine Cossy. « Synthesis of 3-Hydroxypipecolic Acids ». European Journal of Organic Chemistry 2013, n^o 5 (14 janvier 2013) : 809–29. http://dx.doi.org/10.1002/ejoc.201201415.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Krishnamurthy, Suvratha, Jalli Venkataprasad, Tarun Chand Vagvala, Tetsuji Moriguchi et Akihiko Tsuge. « α-Chymotrypsin andl-acylase aided synthesis of 5-hydroxypipecolic acid via Jacobsen's hydrolytic kinetic resolution of epoxy amino acids ». RSC Advances 5, n^o 64 (2015) : 52154–60. http://dx.doi.org/10.1039/c5ra09207h.

Texte intégral

Résumé :

5-hydroxypipecolic acid synthesis from intramolecular reaction of epoxy amino acids; enantiomers separated by hydrolase and diastereomeric epoxide separated by Jacobsen's hydrolytic kinetic resolution.

Styles APA, Harvard, Vancouver, ISO, etc.

Cochi, Anne, Domingo Gomez Pardo et Janine Cossy. « ChemInform Abstract : Synthesis of 3-Hydroxypipecolic Acids ». ChemInform 44, n^o 28 (21 juin 2013) : no. http://dx.doi.org/10.1002/chin.201328209.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Alegret, Carlos, Xavier Ginesta et Antoni Riera. « Asymmetric Synthesis ofcis-4- andtrans-3-Hydroxypipecolic Acids ». European Journal of Organic Chemistry 2008, n^o 10 (avril 2008) : 1789–96. http://dx.doi.org/10.1002/ejoc.200701103.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Kite, Geoffrey C., et Michael J. Hughes. « Analysis of hydroxypipecolic acids by gas chromatography-mass spectrometry ». Phytochemical Analysis 8, n^o 6 (novembre 1997) : 294–301. http://dx.doi.org/10.1002/(sici)1099-1565(199711/12)8:6<294 ::aid-pca372>3.0.co;2-r.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Chiou, Wen-Hua, Gau-Hong Lin et Chih-Wei Liang. « Facile Syntheses of Enantiopure 3-Hydroxypiperidine Derivatives and 3-Hydroxypipecolic Acids ». Journal of Organic Chemistry 75, n^o 5 (5 mars 2010) : 1748–51. http://dx.doi.org/10.1021/jo902324h.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Cordero, Franca M., Simona Bonollo, Fabrizio Machetti et Alberto Brandi. « The Synthesis of 4-Hydroxypipecolic Acids by Stereoselective Cycloaddition of Configurationally Stable Nitrones ». European Journal of Organic Chemistry 2006, n^o 14 (juillet 2006) : 3235–41. http://dx.doi.org/10.1002/ejoc.200600104.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

FERREIRA, F., C. GRECK et P. GENET. « ChemInform Abstract : Stereocontrolled Syntheses of trans-3-Hydroxypipecolic Acids and Application to (-)-Swainsonine. » ChemInform 29, n^o 6 (24 juin 2010) : no. http://dx.doi.org/10.1002/chin.199806241.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Guan, Jiaojiao, Yilei Lu, Zixuan Dai, Songyin Zhao, Yan Xu et Yao Nie. « R97 at “Handlebar” Binding Mode in Active Pocket Plays an Important Role in Fe(II)/α-Ketoglutaric Acid-Dependent Dioxygenase cis-P3H-Mediated Selective Synthesis of (2S,3R)-3-Hydroxypipecolic Acid ». Molecules 28, n^o 4 (15 février 2023) : 1854. http://dx.doi.org/10.3390/molecules28041854.

Texte intégral

Résumé :

Pipecolic acid (Pip) and its derivative hydroxypipecolic acids, such as (2S,3R)-3-hydroxypipecolic acid (cis-3-L-HyPip), are components of many natural and synthetic bioactive molecules. Fe(II)/α-ketoglutaric acid (Fe(II)/2-OG)-dependent dioxygenases can catalyze the hydroxylation of pipecolic acid. However, the available enzymes with desired activity and selectivity are limited. Herein, we compare the possible candidates in the Fe(II)/2-OG-dependent dioxygenase family, and cis-P3H is selected for potentially catalyzing selective hydroxylation of L-Pip. cis-P3H was further engineered to increase its catalytic efficiency toward L-Pip. By analyzing the structural confirmation and residue composition in substrate-binding pocket, a “handlebar” mode of molecular interactions is proposed. Using molecular docking, virtual mutation analysis, and dynamic simulations, R97, E112, L57, and G282 were identified as the key residues for subsequent site-directed saturation mutagenesis of cis-P3H. Consequently, the variant R97M showed an increased catalytic efficiency toward L-Pip. In this study, the kcat/Km value of the positive mutant R97M was about 1.83-fold that of the wild type. The mutation R97M would break the salt bridge between R97 and L-Pip and weaken the positive-positive interaction between R97 and R95. Therefore, the force on the amino and carboxyl groups of L-Pip was lightly balanced, allowing the molecule to be stabilized in the active pocket. These results provide a potential way of improving cis-P3H catalytic activity through rational protein engineering.

Styles APA, Harvard, Vancouver, ISO, etc.

Wang, Bing, et Run-Hua Liu. « Stereospecific, Flexible and Redox-Economic Asymmetric Synthesis ofcis- andtrans-3-Hydroxypipecolic Acids and Analogs ». European Journal of Organic Chemistry 2009, n^o 17 (juin 2009) : 2845–51. http://dx.doi.org/10.1002/ejoc.200900231.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Plus de sources

Thèses sur le sujet "Hydroxypipecolic acids"

SERNISSI, LORENZO. « Synthesis and evaluation of conformationally constrained aminopipecolic acids for the generation of new small-molecule integrin-targeted drugs ». Doctoral thesis, 2016. http://hdl.handle.net/2158/1025518.

Texte intégral

Résumé :

The synthesis of substituted cyclopropane pipecolic acids (CPAs) as conformationally restricted templates for peptidomimetics is reported. A variety of differently substituted (poly)hydroxy- and amino-2-azabicyclo[4.1.0]heptane-1-carboxylic acids were prepared via the Pd-catalyzed methoxycarbonylation of suitably functionalized lactam-derived vinyl phosphates, followed by OH-directed cyclopropanations. Cyclopropane amino acids have been extensively exploited to reduce conformational mobility in peptidomimetics. However, to our knowledge there were no reports on CPAs embodied in peptides. Hence, we employed various substituted CPAs to build linear and cyclic peptidomimetics. In particular, we synthesized two cyclic peptidomimetics bearing the RGD (Arginine-Glycine-Aspartic Acid) sequence, which displayed nanomolar affinity towards both alfa-v-beta-3 and alfa-5-beta-1 integrin subfamilies. These have received increasing attention as therapeutic targets because of their critical role in tumor-induced angiogenesis and metastasis diffusion. Thus, CPAs appear suitable for the generation of novel peptidomimetics for drug discovery.

Styles APA, Harvard, Vancouver, ISO, etc.

Actes de conférences sur le sujet "Hydroxypipecolic acids"

Luna, Amparo, Pedro Almendros et Benito Alcaide. « Diastereoselective direct aldol reaction and subsequent cyclization of 2-azetidinone-tethered azides for the preparation of a 4-hydroxypipecolic acid analogue ». Dans The 13th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland : MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00174.

Texte intégral

Styles APA, Harvard, Vancouver, ISO, etc.

Nous offrons des réductions sur tous les plans premium pour les auteurs dont les œuvres sont incluses dans des sélections littéraires thématiques. Contactez-nous pour obtenir un code promo unique!