Littérature scientifique sur le sujet « Hydroscaffold »
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Articles de revues sur le sujet "Hydroscaffold"
Messelmani, Taha, Anne Le Goff, Zied Souguir, Victoria Maes, Méryl Roudaut, Elodie Vandenhaute, Nathalie Maubon, Cécile Legallais, Eric Leclerc et Rachid Jellali. « Development of Liver-on-Chip Integrating a Hydroscaffold Mimicking the Liver’s Extracellular Matrix ». Bioengineering 9, no 9 (5 septembre 2022) : 443. http://dx.doi.org/10.3390/bioengineering9090443.
Texte intégralBhar, Bibrita, Priyanka Ranta, Pavan Kumar Samudrala et Biman B. Mandal. « Omentum Extracellular Matrix-Silk Fibroin Hydroscaffold Promotes Wound Healing through Vascularization and Tissue Remodeling in the Diabetic Rat Model ». ACS Biomaterials Science & ; Engineering, 26 janvier 2024. http://dx.doi.org/10.1021/acsbiomaterials.3c01877.
Texte intégralRoudaut, Meryl, Amandine Caillaud, Zied Souguir, Lise Bray, Aurore Girardeau, Antoine Rimbert, Mikaël Croyal et al. « Human induced pluripotent stem cells‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism ». Bioengineering & ; Translational Medicine, 16 mars 2024. http://dx.doi.org/10.1002/btm2.10659.
Texte intégralThèses sur le sujet "Hydroscaffold"
Messelmani, Taha. « Development and characterisation of a biomimetic liver on chip featuring 3D hepatic coculture with an endothelial barrier ». Electronic Thesis or Diss., Compiègne, 2023. http://www.theses.fr/2023COMP2736.
Texte intégralDuring drugs development programs, animal models are commonly used for the assessment of the metabolism and toxicity of drug candidates. Several legal frameworks are being settled to promote the replacement, the reduction, and the refinement of these experiments. The liver is a central organ involved in the detoxification of exogenous molecules. Accordingly, the development of models mimicking the functions of the liver remain a challenging objective. Conventionally, liver cells are cultured in vitro in 2D Petri dishes but this conformation leads to a rapid loss of their functions. In recent years, the association between tissue engineering and organ-on-chip technology led to the development of more accurate alternative models that mimic the liver functions. The aim of this thesis is to develop a biomimetic liver-on-chip platform by coupling a hepatocyte biochip and an endothelial-like barrier. The goal is to mimic the passage of molecules through the liver sinusoid endothelial barrier and then their metabolism with the hepatocytes. In the first part, we used organ-on-chip technology and ECM-based hydroscaffold to organise the cells in 3D structures. The potential of our model was compared with static Petri dishes and the spheroids formed were characterised structurally and functionally. In the second part, we characterized the formation of an endothelial barrier and identified specific markers indicating the conservation of the phenotype of endothelial cells. We established the coculture conditions and analysed the potential of coupling the endothelial barrier with the hepatocyte-on-chip to metabolize the APAP as a candidate molecule. Finally, we analysed the metabolomic signature of each condition, crosstalk between the cells, and identified the metabolic signature of APAP injury and described the reactions happening at metabolic level. In the last part, we proposed tracks of improvement by using primary hepatocytes or by integrating the endothelial barrier and the hepatocytes in the same bi-compartmentalized biochip
Actes de conférences sur le sujet "Hydroscaffold"
Miollis, Frederick De, Zied Souguir, Charles Poiraud, Joseph de Saxce, Lucie Dercourt, Elodie Vandenhaute, Audrey Vincent, Nathalie Maubon, Isabelle Van Seuningen et Vincent Senez. « Engineering Microscale Biomimetic Hydroscaffold for Dynamic Three-Dimensional Modeling of Pancreatic Cancer ». Dans 2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2021. http://dx.doi.org/10.1109/mems51782.2021.9375317.
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