Bibliographies thématiques / Human primary liver cancer

Littérature scientifique sur le sujet « Human primary liver cancer »

Auteur : Grafiati
Publié le 11 mars 2023

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Articles de revues sur le sujet "Human primary liver cancer"

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Zajkowska, Monika, et Barbara Mroczko. « Chemokines in Primary Liver Cancer ». International Journal of Molecular Sciences 23, no 16 (9 août 2022) : 8846. http://dx.doi.org/10.3390/ijms23168846.

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The liver is responsible for extremely important functions in the human body. In the liver’s structure, we distinguish between connective tissue (stroma) and parenchyma, the latter of which is formed from the basic structural and functional units of the liver—hepatocytes. There are many factors, that negatively affect the liver cells, contributing to their damage. This may lead to fibrosis, liver failure and, in consequence, primary liver cancer, which is the sixth most commonly diagnosed malignancy and the fourth leading cause of cancer death worldwide. Chemokines are a large family of secreted proteins. Their main role is to direct the recruitment and migration of cells to sites of inflammation or injury. Some authors suggest that these proteins might play a potential role in the development of many malignancies, including primary liver cancer. The aim of this study was to evaluate and summarize the knowledge regarding liver diseases, especially primary liver cancer (HCC) and the participation of chemokines in the development of this malignancy. Chemokines involved in the initiation of this type of tumor belong mainly to the CC and CXC chemokines. Their significant role in the course of hepatocellular carcinoma proves their usefulness in detecting and monitoring the course and treatment in patients with this disease.
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Takamoto, Takeshi, et Masatoshi Makuuchi. « Precision surgery for primary liver cancer ». Cancer Biology & ; Medicine 16, no 3 (1 août 2019) : 475–85. http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0194.

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Liver resection remains the best curative option for primary liver cancer, such as hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma. In particular, in liver resection for HCC, anatomical resection of the tumor-bearing segments is highly recommended to eradicate the intrahepatic metastases spreading through portal venous branches. Anatomical liver resection, including anatomical segmentectomy and subsegmentectomy using the dye-injection method, is technically demanding and requires experience for completion of a precise procedure. The recent development of imaging studies and new computer technologies has allowed for the preoperative design of the operative procedure, intraoperative navigation, and postoperative quality evaluation of the anatomical liver resection. Although these new technologies are related to the progress of artificial intelligence, the actual operative procedure is still performed as human-hand work. A precise anatomical liver resection still requires meticulous exposure of the boundary of hepatic venous tributaries with deep knowledge of liver anatomy and utilization of intraoperative ultrasonography.
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Christa, Laurence, Marie-Thérèse Simon, Jean-Pierre Flinois, Rolf Gebhardt, Christian Brechot et Chantal Lasserre. « Overexpression of glutamine synthetase in human primary liver cancer ». Gastroenterology 106, no 5 (mai 1994) : 1312–20. http://dx.doi.org/10.1016/0016-5085(94)90024-8.

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Liu, Yewei, Shuncong Wang, Xiaohui Zhao, Yuanbo Feng, Guy Bormans, Johan Swinnen, Raymond Oyen, Gang Huang, Yicheng Ni et Yue Li. « Predicting Clinical Efficacy of Vascular Disrupting Agents in Rodent Models of Primary and Secondary Liver Cancers : An Overview with Imaging-Histopathology Correlation ». Diagnostics 10, no 2 (31 janvier 2020) : 78. http://dx.doi.org/10.3390/diagnostics10020078.

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Vascular disrupting agents (VDAs) have entered clinical trials for over 15 years. As the leading VDA, combretastatin A4 phosphate (CA4P) has been evaluated in combination with chemotherapy and molecular targeting agents among patients with ovarian cancer, lung cancer and thyroid cancer, but still remains rarely explored in human liver cancers. To overcome tumor residues and regrowth after CA4P monotherapy, a novel dual targeting pan-anticancer theragnostic strategy, i.e., OncoCiDia, has been developed and shown promise previously in secondary liver tumor models. Animal model of primary liver cancer is time consuming to induce, but of value for more closely mimicking human liver cancers in terms of tumor angiogenesis, histopathological heterogeneity, cellular differentiation, tumor components, cancer progression and therapeutic response. Being increasingly adopted in VDA researches, multiparametric magnetic resonance imaging (MRI) provides imaging biomarkers to reflect in vivo tumor responses to drugs. In this article as a chapter of a doctoral thesis, we overview the construction and clinical relevance of primary and secondary liver cancer models in rodents. Target selection for CA4P therapy assisted by enhanced MRI using hepatobiliary contrast agents (CAs), and therapeutic efficacy evaluated by using MRI with a non-specific contrast agent, dynamic contrast enhanced (DCE) imaging, diffusion weighted imaging (DWI) are also described. We then summarize diverse responses among primary hepatocellular carcinomas (HCCs), secondary liver and pancreatic tumors to CA4P, which appeared to be related to tumor size, vascularity, and cellular differentiation. In general, imaging-histopathology correlation studies allow to conclude that CA4P tends to be more effective in secondary liver tumors and in more differentiated HCCs, but less effective in less differentiated HCCs and implanted pancreatic tumor. Notably, cirrhotic liver may be responsive to CA4P as well. All these could be instructive for future clinical trials of VDAs.
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Maki, Harufumi, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Yasushi Harihara et Norihiro Kokudo. « Real-time confocal laser endomicroscopic evaluation of primary liver cancer based on human liver autofluorescence ». Journal of Surgical Oncology 115, no 2 (4 novembre 2016) : 151–57. http://dx.doi.org/10.1002/jso.24491.

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Chenivesse, Xavier, Dominique Franco et Christian Bréchot. « MDR1 (multidrug resistance) gene expression in human primary liver cancer and cirrhosis ». Journal of Hepatology 18, no 2 (janvier 1993) : 168–72. http://dx.doi.org/10.1016/s0168-8278(05)80243-0.

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Kung, Janet W. C., Ian S. Currie, Stuart J. Forbes et James A. Ross. « Liver Development, Regeneration, and Carcinogenesis ». Journal of Biomedicine and Biotechnology 2010 (2010) : 1–8. http://dx.doi.org/10.1155/2010/984248.

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The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluripotent stem cells into hepatocyte-like cells. As a result, the understanding of the cell biology of proliferation and differentiation in the liver has been improved. This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation. In parallel, the mechanisms regulating cancer cell biology are now clearer, providing fertile soil for novel therapeutic approaches. Recognition of the relationships between development, regeneration, and carcinogenesis, and the increasing evidence for the role of stem cells in all of these areas, has sparked fresh enthusiasm in understanding the underlying molecular mechanisms and has led to new targeted therapies for liver cirrhosis and primary liver cancers.
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Liu, Nian, Zhipeng Meng, Guiyu Lou, Weiping Zhou, Xiaoqiong Wang, Yunfeng Zhang, Lisheng Zhang et al. « Hepatocarcinogenesis in FXR−/− Mice Mimics Human HCC Progression That Operates through HNF1α Regulation of FXR Expression ». Molecular Endocrinology 26, no 5 (1 mai 2012) : 775–85. http://dx.doi.org/10.1210/me.2011-1383.

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Abstract Farnesoid X receptor (FXR) (nuclear receptor subfamily 1, group H, member 4) is a member of nuclear hormone receptor superfamily, which plays essential roles in metabolism of bile acids, lipid, and glucose. We previously showed spontaneously hepatocarcinogenesis in aged FXR−/− mice, but its relevance to human hepatocellular carcinoma (HCC) is unclear. Here, we report a systematical analysis of hepatocarcinogenesis in FXR−/− mice and FXR expression in human liver cancer. In this study, liver tissues obtained from FXR−/− and wild-type mice at different ages were compared by microarray gene profiling, histological staining, chemical analysis, and quantitative real-time PCR. Primary hepatic stellate cells and primary hepatocytes isolated from FXR−/− and wild-type mice were also analyzed and compared. The results showed that the altered genes in FXR−/− livers were mainly related to metabolism, inflammation, and fibrosis, which suggest that hepatocarcinogenesis in FXR−/− mice recapitulated the progression of human liver cancer. Indeed, FXR expression in human HCC was down-regulated compared with normal liver tissues. Furthermore, the proinflammatory cytokines, which were up-regulated in human HCC microenvironment, decreased FXR expression by inhibiting the transactivity of hepatic nuclear factor 1α on FXR gene promoter. Our study thereby demonstrates that the down-regulation of FXR has an important role in human hepatocarcinogenesis and FXR−/− mice provide a unique animal model for HCC study.
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Gong, Yongling. « Therapy response of Chinese herbal medicine in primary liver cancer. » Journal of Clinical Oncology 33, no 3_suppl (20 janvier 2015) : 488. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.488.

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488 Background: Aiming at starting the ball rolling and contributing humble effort to promote Chinese traditional medicine, we report successful cases of Chinese herbal decoction for primary liver cancer. Methods: Conventional therapy of surgical resection and artery catheterization chemotherapy was applied in cases reported. In the meantime, we administered Chinese medicine (Gan Decoction, mixed with a variety of effective herbal components) to help them to recover from poor condition. Results: After taking the Chinese herbal decoction for months, the tumour marker (AFP, CA19-9) level dramatically decreased to the normal range. Most residual intrahepatic metastatic sites reduced according to ultrasonography/CT imaging, and the patient felt free from the complaint of abdominal discomfort. The quality of life has been greatly improved, we managed to have prolonged the PFS (Progression-Free-Survival) and TTP (Time-to-Progression) from the onset to date. Conclusions: Chinese medicine considers human body as a dynamic platform in which all organs are correlative and bind each other. Each case showed distinguished liver cancer progression and heterogeneity with individual therapy response. Our report suggested that Chinese herbs might be an additional choice with its better benefits and tolerability in the treatment of primary liver cancer.
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Franko, Andras, Sonja Hartwig, Jörg Kotzka, Marc Ruoß, Andreas K. Nüssler, Alfred Königsrainer, Hans-Ulrich Häring, Stefan Lehr et Andreas Peter. « Identification of the Secreted Proteins Originated from Primary Human Hepatocytes and HepG2 Cells ». Nutrients 11, no 8 (3 août 2019) : 1795. http://dx.doi.org/10.3390/nu11081795.

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The liver plays a pivotal role in whole-body carbohydrate, lipid, and protein metabolism. One of the key regulators of glucose and lipid metabolism are hepatokines, which are found among the liver secreted proteins, defined as liver secretome. To elucidate the composition of the human liver secretome and identify hepatokines in primary human hepatocytes (PHH), we conducted comprehensive protein profiling on conditioned medium (CM) of PHH. Secretome profiling using liquid chromatography-electrospray ionization tandem mass spectrometry (LC-MS/MS) identified 691 potential hepatokines in PHH. Subsequently, pathway analysis assigned these proteins to acute phase response, coagulation, and complement system pathways. The secretome of PHH was compared to the secreted proteins of the liver hepatoma cell line HepG2. Although the secretome of PHH and HepG2 cells show a high overlap, the HepG2 secretome rather mirrors the fetal liver with some cancer characteristics. Collectively, our study represents one of the most comprehensive secretome profiling approaches for PHH, allowing new insights into the composition of the secretome derived from primary human material, and points out strength and weakness of using HepG2 cell secretome as a model for the analysis of the human liver secretome.
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Thèses sur le sujet "Human primary liver cancer"

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曹德良 et De-liang Cao. « Over-expression of aldose reductase and a novel aldose reductase-like gene in human primary liver cancers ». Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31234616.

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Cao, De-liang. « Over-expression of aldose reductase and a novel aldose reductase-like gene in human primary liver cancers / ». Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17506438.

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Ladep, Nimzing. « Primary liver cancer : epidemiological and biomarker discovery studies ». Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24683.

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With previous reports indicating changes in mortality, risk factors and management of primary liver cancer (PLC), evaluation of current trends in the incidence and mortality rates was indicated. Late diagnosis has been implicated to be a major contributor to the high fatality rates of PLC. This work aimed at: • studying trends of PLC by subcategories globally in general, and in England and Wales, in particular; • investigating liver-related morbidities of HIV infected patients in an African setting; and • discovering urinary biomarkers of hepatocellular carcinoma. The World Health Organisation (WHO) and Small Area Health Statistics Unit (SAHSU) databases were interrogated respectively, in order to achieve the first aim. The second aim was achieved through utilisation of databases of an African-based HIV treatment programme- AIDS Prevention Initiative in Nigeria (APIN), located in Jos, Nigeria. The European Union-funded Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) case-control study in three West African countries was the platform through which urinary metabolic profiling was accomplished. Proton nuclear magnetic resonance spectroscopy (NMR) and parallel ultra-performance liquid chromatography mass spectrometry (UPLC-MS) were used for biomarker discovery studies. Mortality rates of intrahepatic bile duct carcinoma (IHBD) increased in all countries that were studied. Misclassification of hilar cholangiocarcinoma accounted for only a small increase in the rate of IHBD in England and Wales. With over 90% screening rate for viral hepatitides, the rates of hepatitis B (HBV), hepatitis C (HCV) and HBV/HCV in HIV-infected patients in the APIN programme were 17.8%, 11.3% and 2.5% respectively. There was attenuated immune response as well as significantly lower survival observed in HBV/HIV co-infection, relative to HIV mono-infected patients (p=0.0097). Whereas single urinary metabolites, including acetylcarnitine, N-acetylglutamate, betaine aldehyde, 3'-sialyllactose, methionine among others possessed high discriminatory power to diagnose HCC, a combination of three metabolites: 3'-sialyllactose, methionine and 9-decenoylcarnitine significantly outperformed serum alpha-fetoprotein (AFP) in the diagnosis of HCC in a cirrhosis population (area under the receiver operating characteristic curve; [urinary panel= 0.96] compared to [AFP = 0.64]). This work informs a critical assessment of current control strategies in the prevention of HCC, and potentially assists in the development of more affordable means of early detection of PLC for most affected regions of the world.
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Hubbard, J. G. H. « Primary tamoxifen therapy in human breast cancer ». Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341491.

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Clifford, Steven Curtis. « Determinants of chemosensitivity in human primary bladder cancer ». Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239771.

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Collier, Jane Davina. « Molecular mechanisms in human hepatocellular carcinoma ». Thesis, University of Newcastle Upon Tyne, 1993. http://hdl.handle.net/10443/693.

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Hepatocellular carcinoma (HCQ is one of the commonest cancers worldwide. There is, however, a marked geographical variation in incidence and it has been suggested that the pathogenesis may vary in different parts of the world. A retrospective analysis of 110 HCC patients was initially undertaken which confirmed that only 29% of British patients had markers of hepatitis B infection, suggesting a possible role for other environmental agents in the pathogenesis, and that 80% of patients had underlying cirrhosis. The nature of the strong relationship between HCC and cirrhosis has not been established but it has been postulated that increased hepatocyte turnover in the cirrhotic liver may predispose to DNA damage by environmental mutagens. Cell proliferation is required to express the strongly promutagenic DNA base lesion 0'-methylguanine, produced by alkylating agents, as a mutation. &- methylguanine is repaired by the DNA repair enzyme 06-methylguanine-DNA methyltTansferase (06-MT). A microassay was developed which could reliably measure 06-MT levels in liver biopsy samples. Using this approach 06-MT levels were found to be significantly lower in cirrhotic liver when compared to non-cirrhotic and normal liver tissue. No correlation was found between lymphocyte and liver levels from individual patients with liver disease indicating that the deficiency in DNA repair is disease-a nd tissue-specific. Three polyclonal antibodies were subsequently raised to 06-MT peptides and characterised by immunoblotting in an attempt to establish the tissue distribution of the enzyme in liver. Although none of the antisera were able to detect &-MT in tissue sections they were used to analyse structural differences in the enzyme between cirrhotic and non-cirrhotic liver using SDS-PAGE followed by immunoblotting and fluorography. A band of M, 24,000r,e presentingn ative enzyme, was visualised by fluorography in all liver extracts. Densitometry of these bands correlated with the enzyme activity determined by the direct enzyme assay, validating the assay findings. Other small molecular weight bands were seen in all liver extracts and comparison with immunoblots suggested that these bands represent C-terminal truncated enzyme. The spectrum of smaller molecular weight enzyme forms was similar in cirrhotic and non-cirrhotic liver. It was, thus, concluded that although 06-MT levels were lower in'cirrhosis this was not accounted for by structural differences in the enzyme. DNA mutations (G to A) produced by the failure to repair 06-methylguanine are known to activate oncogenes and turnour suppressor genes such as p53. However only 5/55 (9%) of HCC expressed mutant p53. Other factors potentially involved in hepatocarcinogenesis include the growth factor TGF-a and a growth factor receptor encoded by the c-erb B-2 proto-oncogene. Expression of TGF-a and the C-erbB -2 oncoprotein were seen in 8/28 (28%) and 2/26 (8%) of HCC respectively, findings which differ from those observed in HCC from the Far East. Deficient DNA repair by &-MT provides one possible reason why cirrhosis is an important risk factor for the development of HCC. However, failure to repair 06-mothylguanine does not result in mutations within the p53 gene in British HCC. Furthermore, the finding of low expression of mutant p53, TGF-a and the c-erb B-2 oncoprotein in HCC from Britain compared to HCC from the Far East and Africa suggests geographical differences in the molecular mechanisms involved in hepatocarcinogenesis between areas of high and low HCC prevalence.
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Chan, Chun-Fai. « Study of cancer vaccine candidates for human hepatocellular carcinoma (HCC) / ». View abstract or full-text, 2004. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202004%20CHAN.

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AOKI, KUNIO, RYUICHIRO SASAKI et ZHU-MIN HUANG. « Trends in Mortality from Primary Liver Cancer, Cirrhosis of the Liver, Virus Hepatitis, and Other Liver Diseases 1968-1984 in Japan ». Nagoya University School of Medicine, 1987. http://hdl.handle.net/2237/17497.

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Easom, Nicholas James Wilson. « Interactions between tumour and natural killer cells in primary and secondary liver cancer ». Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10042188/.

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Natural killer (NK) cells are implicated in tumour surveillance and control in a number of settings. The liver contains large numbers of NK cells and hepatocellular carcinoma (HCC) has been shown to express various ligands that permit interactions with NK cells, some of which have been shown to have prognostic significance. Similar prognostic associations have been shown for colorectal cancer, a tumour which commonly metastasizes to the liver. However the mechanistic underpinning of these effects is unclear. This thesis describes a survey of soluble NKG2D ligand expression in patients with HCC caused by chronic hepatitis B (CHB), patients with CHB without cancer, and healthy controls. ULBP1 was found to be raised in HCC patients; where it was associated with poor survival, and in active CHB; where it was associated with hepatitis B viral load. ULBP1 was not seen in secondary liver tumours, suggesting that this protein may be useful as a biomarker of severe disease or to monitor treatment response. The other NKG2D ligands MICA, MICB, ULBP2 and ULBP3 were not found to be elevated in patient serum. Soluble NKG2D ligands did not affect NKG2D expression by circulating NK cells. Tumour infiltrating NK cells have the potential to be important effector cells, but are functionally defective. This work builds on recent advances in the understanding of liver-resident NK cells to characterise the functional defect in primary and secondary liver cancers, using human ex vivo intrahepatic and tumour-infiltrating NK cells. Using an in vitro model of HCC we have investigated the mechanisms for this defect and examine the potential for IL- 15 to restore NK cell cytotoxicity and cytokine production. Ex-vivo tumourinfiltrating NK cells had reduced NKG2D expression, IFNγ production and degranulation potential compared with paired intrahepatic NK cells, but maintained expression of NKp46. We were able to recapitulate this phenotype by co-culture with an HCC cell line, but were not able to protect NK cells from NKG2D downregulation and functional inhibition by NKG2D blockade. However, IL-15 was able to restore function after HCC exposure. This model may serve as an in-vitro assay for future therapeutics targeting tumour-infiltrating NK cells.
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Cunha, Virgínia Filipa Pereira Monteiro da. « Human adipose tissue primary cultures and impact in prostate cancer ». Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/8985.

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Mestrado em Biologia Aplicada - Molecular e Celular
Prostate cancer (Pca) is one of the most frequent diagnosed neoplasies and the second cause of cancer-related death in the world, in men. Between others risk factors, obesity has been associated to Pca although the innerent mechanisms to this association remain to be clear. With this work, throuhg in vitro studies, we wish to contribute to the understanding of the impact of white adipose tissue and its sub-fractions (adipocytes and stromal vascular fraction), from visceral and periprostatic anatomic regions, in celular proliferation, apoptosis and invasion of castration sensitivity (LNCaP) and castration resistant (PC-3) prostate cells. With the purpose of obtaining answers directly from humam studies, were performed visceral and periprostatic adipose tissue primary cultures obtained during urologic surgeries (radical prostatectomy and prostatic adenomectomy) (n=16). Adipose tissue was used to make primary organotipical cultures (WAT) and after collagenase digestion adipocytes and SVF primary cultures. Sobrenatants and infranatants of each culture were collect and used as conditioned medium representing adipokines production. LNCaP and PC-3 cell lines were stimulated with these mediums and apoptosis, proliferation and invasion were evaluated, in vitro. This study model represent a potential form for analyze the impact of adipose tissue in tumor cells, allowing to evaluate adipose tissue-tumor interactions. The results show that adipose tissue promotes tumor cells proliferation, that periprostatic adipose tissue increase apoptosis in obese individuals and that SVF subfraction suppresses invasion of PC-3 cells through a direct effect in tumor cells.
O Cancro da próstata (CaP) é uma das neoplasias mais frequentemente diagnosticadas e a segunda causa de morte por cancro no mundo nos homens. Entre outros factores de risco, a obesidade tem sido frequentemente associada a CaP, embora permaneçam por esclarecer os mecanismos subjacentes a esta associação. Com o presente trabalho pretendeu-se através de estudos in vitro, contribuir para a compreensão do impacto do tecido adiposo branco e suas sub-fracções (adipócitos e fracção vascular estromal), com origens anatómicas periprostática e viceral, na proliferação, apoptose, e invasão celular de células de cancro da próstata sensíveis à castração (LNCaP) e resistentes à castração (PC-3). Com o propósito de obter respostas directamente através de estudos em humanos, foram efectuadas culturas primárias de tecido adiposo periprostático e visceral obtido durante cirurgias urológicas (prostatectomia radical e adenomectomia prostática) (n=16). O tecido adiposo foi utilizado para realizar culturas primárias organotípicas (tecido adiposo total fraccionado) e após digestão com colagenase culturas primárias de adipócitos e de células da fracção vascular estromal do tecido adiposo. Foram colhidos sobrenadantes e infranadantes destas culturas de tecido adiposo e utilizados como meios condicionados representativos da produção de adipocinas. As linhas celulares LNCaP e PC-3 foram estimuladas com estes meios e avaliados a apoptose, proliferação celular e invasividade tumoral in vitro. Este modelo de estudo representa um potencial meio para análise do impacto do tecido adiposo nas células tumorais, permitindo avaliar as interacções tecido adiposo-tumor. Os resultados evidenciam que o tecido adiposo promove a proliferação das células tumorais, que o tecido adiposo periprostático aumenta a apoptose em indivíduos obesos e que os SVF suprimem a invasão das PC-3 através de um efeito directo nas células tumorais.
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Livres sur le sujet "Human primary liver cancer"

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Reau, Nancy, et Fred Poordad, dir. Primary Liver Cancer. Totowa, NJ : Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-863-4.

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Gu, Jianren. Primary Liver Cancer. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2.

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Chao-yu, Tʼang, Wu Meng-chʼao et Hsia Sui-sheng, dir. Primary liver cancer. Beijing : China Academic Publishers, 1989.

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Tobe, Takayoshi, Haruo Kameda, Masahiko Okudaira, Masao Ohto, Yasuo Endo, Michio Mito, Eizo Okamoto, Kyuichi Tanikawa et Masamichi Kojiro, dir. Primary Liver Cancer in Japan. Tokyo : Springer Japan, 1992. http://dx.doi.org/10.1007/978-4-431-68177-9.

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Takayoshi, Tobe, dir. Primary liver cancer in Japan. Tokyo : Springer-Verlag, 1992.

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Williams, Roger, et Simon D. Taylor-Robinson, dir. Clinical Dilemmas in Primary Liver Cancer. Oxford, UK : Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781119962205.

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K, Hussain Hero, et Francis Isaac R, dir. Primary carcinomas of the liver. Cambridge : Cambridge University Press, 2010.

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Reau, Nancy, et Fred Poordad. Primary liver cancer : Surveillance, diagnosis, and treatment. New York : Humana Press, 2012.

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1933-, Herfarth Christian, Schlag P. 1948- et Hohenberger P. 1953-, dir. Therapeutic strategies in primary and metastatic liver cancer. Berlin : Springer-Verlag, 1986.

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Felix, Lee, dir. Liver cancer : New research. New York : Nova Science Publishers, 2004.

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Chapitres de livres sur le sujet "Human primary liver cancer"

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Cárdenes, Higinia R., et Foster Lasley. « Primary Liver Cancer ». Dans Stereotactic Body Radiation Therapy, 163–82. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/174_2012_548.

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Braun-Falco, Markus, Henry J. Mankin, Sharon L. Wenger, Markus Braun-Falco, Stephan DiSean Kendall, Gerard C. Blobe, Christoph K. Weber et al. « Primary Liver Cancer ». Dans Encyclopedia of Molecular Mechanisms of Disease, 1721. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8725.

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Tian, Zhigang, et Yongyan Chen. « Immunology of Liver ». Dans Primary Liver Cancer, 233–75. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_8.

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Gu, Jianren, Wenxin Qin et Zhigang Zhang. « Concepts, Challenges and Perspectives in Cancer Research ». Dans Primary Liver Cancer, 1–17. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_1.

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Chen, Zhinan, Huijie Bian, Jinliang Xing, Jianli Jiang, Yu Li, Xiaoling Yu, Li Wang, Xiangmin Yang et Chengong Liao. « Immunotherapy of Hepatocellular Carcinoma ». Dans Primary Liver Cancer, 299–337. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_10.

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Kensler, Thomas W., John D. Groopman, Patricia A. Egner, Alvaro Muñoz, GengSun Qian et JianGuo Chen. « Chemoprevention of Hepatic Cancer in Aflatoxin Endemic Areas ». Dans Primary Liver Cancer, 339–65. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_11.

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Tang, Zhaoyou. « Metastasis of Hepatic Cancer ». Dans Primary Liver Cancer, 367–98. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_12.

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Wu, Mengchao, Feng Shen, Jiamei Yang, Weiping Zhou, Yiqun Yan et Xiaohui Fu. « Integrated Treatment of Hepatic Cancer ». Dans Primary Liver Cancer, 399–431. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_13.

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Zheng, Shusen. « Liver Transplantation for Hepatocellular Carcinoma ». Dans Primary Liver Cancer, 433–56. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_14.

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Gu, Jianren, Xianghuo He, Zhenfeng Zhang, Weijie Guo, Zhiao Chen et Yingjun Zhao. « Systemic Dysregulation in the Development of Hepatocellular Carcinoma ». Dans Primary Liver Cancer, 19–44. Berlin, Heidelberg : Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-28702-2_2.

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Actes de conférences sur le sujet "Human primary liver cancer"

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Chen, Huanhuan Joyce, Jian Sun, Harry Hou, Winfried Edelmann, Xiling Shen et Steven M. Lipkin. « Abstract 3118 : Chemokine-targeted colorectal cancer : improved models of human primary tumor formation, liver metastasis and chemoresistance ». Dans Proceedings : AACR Annual Meeting 2014 ; April 5-9, 2014 ; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3118.

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Nascimento, Ranier Colbek, et Sabrina Ribas Freitas. « A 29-YEAR-OLD PREGNANT WOMAN WITH METASTATIC BREAST CANCER : A CASE REPORT ». Dans Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2107.

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Pregnancy-associated breast cancer (PABC) is defined as a breast cancer diagnosed during pregnancy, lactation, or in the first postpartum year. PABC is a rare complication that occurs in approximately 0.01% to 0.03% of all pregnancies. The difficulty in diagnosis worsens the prognosis. D.G., 29-year-old, female, noted a mass in her right breast in June 2020. One month later with 13+4 weeks’ gestation, she presented to the obstetrics emergency with recurrent episodes of lower back pain. She was released home with pain relief and was instructed to realize a mammography due to the presence of a 4-cm mass on physical examination of the right breast. Patient returned 12 days later with severe low back pain, a BIRADS 4C mammography, and multiple liver lesions in total abdomen ultrasound. Core-needle biopsy demonstrated a stage II invasive ductal carcinoma with hormone receptors positive and human epidermal growth factor receptor 2 positive. There is involvement of the axilla and intramammary lymph nodes. Magnetic resonance imaging of the lower back and sacroiliac joint was performed and found multiple lesions suspected of metastasis in the inferior thoracic vertebrae, lumbar vertebrae, sacrum, ilium, and femurs. Computed tomography (CT) of the thorax identified a 2.3×1.8 cm irregular lesion in the right breast compatible with the primary neoplasm. Chemotherapy was initiated till she was 31 weeks’ gestation. After childbirth, she reinitiates chemotherapy. Three months later, the patient has convulsive episodes. Cranial CT was done and found multiple lesions compatible with brain metastasis, so she initiated brain radiotherapy. PABC can present itself as a challenging situation with nonspecific symptoms and at an advanced stage. Therefore, it is important to have the PABC in our list of differential diagnoses in this patient.
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El Kholy, Wael A. « Corrosion Control for Safety and Integrity of Pipelines ». Dans ASME 2006 Pressure Vessels and Piping/ICPVT-11 Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/pvp2006-icpvt-11-93429.

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Corrosion directly affects our lives by reducing the integrity of possessions. All pipelines, even the best designed and maintained, deteriorate with time. The primary cause of this deterioration is corrosion. Corrosion in metal can be compared to cancer in human body. Both act very slowly without being easily visible and by the time one notices it, serious damage has been done. Owing to corrosion, billions of dollars are wasted in various industries, refineries, petrochemical plants and various underground pipelines and structures in the field of oil, gas, water etc. For the safety and integrity of underground pipelines it is imperative to adopt various methods of corrosion prevention to retard corrosion and thus increase the active working life of pipelines. This paper provides information about various types of corrosion and methods of both inline and outer surface corrosion inspection and monitoring. It also discusses means of pipeline protection, corrosion control and rehabilitation.
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Chu, Tianjiao. « The pathogenesis and treatment of primary liver cancer ». Dans 2017 4th International Conference on Machinery, Materials and Computer (MACMC 2017). Paris, France : Atlantis Press, 2018. http://dx.doi.org/10.2991/macmc-17.2018.86.

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Liu, Yunxiang, et Qi Pan. « Association analysis of Primary liver cancer based on Apriori Algorithm ». Dans 2019 4th International Conference on Intelligent Informatics and Biomedical Sciences (ICIIBMS). IEEE, 2019. http://dx.doi.org/10.1109/iciibms46890.2019.8991456.

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McGlynn, Katherine A., George W. Divine, Vikrant V. Sahasrabuddhe, Lawrence S. Engel, Ashley VanSlooten, Karen Wells, Marianne Ulcickas Yood et Sharon Hensley Alford. « Abstract 4829 : Statin use and risk of primary liver cancer. » Dans Proceedings : AACR 104th Annual Meeting 2013 ; Apr 6-10, 2013 ; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4829.

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Li, Liyuan, Maoxiang Qian, David Finkelstein, Melissa Johnson, Dolores H. López-Terrada et Liqin Zhu. « Abstract B40 : Model liver cancer metastasis using 3D spheroids derived from primary tumors in liver cancer genetic mouse models ». Dans Abstracts : AACR Special Conference : Advances in Modeling Cancer in Mice : Technology, Biology, and Beyond ; September 24-27, 2017 ; Orlando, Florida. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.mousemodels17-b40.

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Keßler, AnnikaSophia, Luisa Nader, Anna-Lena Scherr, Nathalie Schmitt, Kai Breuhahn, Sofia Weiler, Sarah Luiken et al. « Non-canonical NF-κB signaling induces proliferation in primary liver cancer ». Dans 38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0041-1740770.

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Zhang, Baihua, Fu Wang, Xiang Chen, Hongze Lin et He Huang. « Liver Cancer Diagnosis in CT Employing U-Net ». Dans 2021 13th International Conference on Intelligent Human-Machine Systems and Cybernetics (IHMSC). IEEE, 2021. http://dx.doi.org/10.1109/ihmsc52134.2021.00034.

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Yamashita, Taro, Masao Honda, Kouki Nio, Yasumasa Hara, Takehiro Hayashi, Naoki Oishi, Hajime Sunakozaka, Hajime Takatori et Shuichi Kaneko. « Abstract 262 : The evolution of diverse cancer stem cells in human liver cancer. » Dans Proceedings : AACR 104th Annual Meeting 2013 ; Apr 6-10, 2013 ; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-262.

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Rapports d'organisations sur le sujet "Human primary liver cancer"

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Guo, yaru, et xiaojin Wu. Recombinant human adenovirus p53 combined with transcatheter arterial chemoembolization for liver cancer : a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, septembre 2022. http://dx.doi.org/10.37766/inplasy2022.9.0127.

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Maund, Sophia L. Advancing the Capabilities of an Authentic Ex Vivo Model of Primary Human Prostate Cancer. Fort Belvoir, VA : Defense Technical Information Center, octobre 2014. http://dx.doi.org/10.21236/ada613178.

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Li, Wenjing, Ziyu Kuang et Feng Jiang. Meta-analysis of the therapeutic effect on primary liver cancer treated with Spleen strengthening method combined with western medicine treatment. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, janvier 2021. http://dx.doi.org/10.37766/inplasy2021.1.0043.

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Shen, Dong, Zhuang Xiong, Yangyang Liu, Yan Leng, Houbo Deng, Song Wang, Xiangtong Meng et Tiejun Liu. Efficacy and safety of Chinese herbal medicine combined with Sorafenib in the treatment of primary liver cancer : A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, septembre 2021. http://dx.doi.org/10.37766/inplasy2021.9.0024.

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The aim of this systematic review is to compare Chinese herbal medicine combined with Sorafenib in terms of efficacy and acceptability in the primary liver cancer to better inform clinical practice. To this end, the proposed systematic review will address the following question: Which is the best choice to reduce Efficacy and safety in Patients with primary liver cancer, Chinese herbal medicine combined with Sorafenib or Sorafenib.this systematic review and meta-analysis will evaluate the efficacy and Sorafenib combined with Chinese herbal medicine in the treatment of PLC. Information sources: We will search the following databases from inception up to September 8, 2021: PubMed, Web of Science, Embase, AMED, Cochrane Library, CNKI, VIP, CBM, and Wanfang. There will be no restrictions regarding publication date or language. We will apply a combination of medical keywords and words, including "Sorafenib", "Chinese herbal medicine" and "primary liver cancer". Additionally, we will manually search all reference lists from relevant systematic reviews to find other eligible studies.
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Chen, Zhichao, Jiefang Wan et Yonghua Lin. Comparison of the efficacy and safety of repeated hepatectomy and radiofrequency ablation in the treatment of primary recurrent liver cancer : a meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, mai 2022. http://dx.doi.org/10.37766/inplasy2022.5.0119.

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Pierce, Lori. The Effect of Radiotherapy Upon Primary Human Mammary Epithelial Cells Which Harbor a Breast Cancer Susceptibility Gene. Fort Belvoir, VA : Defense Technical Information Center, septembre 1999. http://dx.doi.org/10.21236/ada381716.

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Li, Jing. Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells : a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, avril 2020. http://dx.doi.org/10.37766/inplasy2020.4.0026.

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Li, Jing. Effects of artemisinin on proliferation and apoptosis of human liver cancer HepG2 cells : a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, avril 2020. http://dx.doi.org/10.37766/inplasy2020.4.0075.

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Wei, Lai, Niancai Jing, Yi Lu, Jili Yang, Haiyan Lu, Peiyi Chen, Qian Zhou et Yue Zhang. Efficacy and safety of traditional Chinese medicine combined with immune checkpoint inhibitors in the treatment of primary liver cancer : A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, mars 2022. http://dx.doi.org/10.37766/inplasy2022.3.0010.

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Wang, Song, Zhuang Xiong, Yangyang Liu, Yan Leng, Houbo Deng, Dong Shen, Xiangtong Meng et Tiejun Liu. Efficacy and safety of acupuncture and moxibustion combined with the external application of traditional Chinese medicine in the treatment of primary liver cancer : A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, octobre 2021. http://dx.doi.org/10.37766/inplasy2021.10.0029.

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