Littérature scientifique sur le sujet « HS. Repositories »

Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease deriving from the hair follicles. The formation of inflammatory nodules, abscesses, fistulas, and sinus tracts is characterized by a large inflow of key pro-inflammatory mediators, such as IFN-γ, TNF-α, IL-1, IL-17, and IL-12/23. Adalimumab is currently the only Food and Drug Administration (FDA)- and European Medicines Agency (EMA)-approved biologic therapy for moderate to severe HS in adults and adolescents. However, the long-term effectiveness of this TNF-α inhibitor in HS patients has shown to be highly variable. This review aims to review the evidence for emerging therapies that target the main pro-inflammatory cytokines in HS pathogenesis. A review of the literature was conducted, using the PubMed and Google Scholar repositories, as well as Clinicaltrials.gov. Presently, the most promising biologics in phase III trials are anti-IL-17 antibodies, secukinumab, and bimekizumab. Furthermore, an anti-IL-1 biologic, bermekimab, is currently in phase II trials, and shows encouraging results. Overall, the clinical efficacies of all new targeted therapies published up to this point are limited. More studies need to be performed to clarify the precise molecular pathology, and assess the efficacy of biological therapies for HS.

Knowledge management has been developed in the context of enterprises and has its research and applications related to the organisational knowledge perspective. Nevertheless, there are other contexts within which knowledge management can be studied, such as the academic context, which is concerned with the scientific knowledge perspective. Whatever is the context in which knowledge management is studied, communication processes constitute a fundamental issue to be taken into account. As a matter of fact, the relationship between communication and knowledge management has recurrently been approached in the literature, under the technological perspective, having the processes themselves being apparently neglected. Within the academic environment, scholarly communication is also a crucial constituent of knowledge management. However, studies on scientific knowledge management that take account of the scholarly communication process are rare. This piece of research, therefore, aimed to investigate the relationship between knowledge management and the scholarly communication process at a conceptual level, bearing in mind the peculiarities of the scientific knowledge and the academic context. The study is particularly concerned with a theoretical construction of a conceptual model for the knowledge management in the academic context, having the scholarly communication process as its foundation. This theoretical, exploratory, qualitative research is based on the abducting reasoning and the evidential paradigm. Research objectives have been achieved through the combination of two different strategies. The first one consisted of the theoretical construction built upon the literature. The second, via interviews carried out with researchers from different divisions of knowledge. Based on the methods applied, it was possible to draw conclusions. The first one was to associate knowledge management principles to the communication process perspective, particularly to the scholarly communication process. The second was the identification of clues that point to the relationship between tacit scientific knowledge, explicit scientific knowledge and the creation of scientific knowledge in the academic context. The third was to identify the constituents of the knowledge management process within a university environment. The forth was to identify processes related to scientific knowledge management under the open access approach. From these results it was possible to build a conceptual model of the scientific knowledge management, on its tacit and explicit aspects, in the academic context

Departing from the serials crisis, this paper seeks to point out the areas of conflict, which are dominated by three principal agents: the scientific community, publishing houses and libraries. In order to facilitate interaction between these agents the open access movement has been formed, which receives considerable support from the librarianship. Abutted to the Anglo-American university presses, it has been postulated in the scientific community that German universities engage in publishing activities too. The focal point of this work is - apart from an assessment of the current situation and an overview of the Anglo-American university presses - a critical account of the German university press. On the basis of qualitative interviews different publishing houses are critically assessed in terms of their services offered. In a short excursus this paper describes subject-related publishing activities in the context of the open access movement. In conclusion this paper will expound the problems of German university presses – and formulate an outlook as to what may be the future course of the industry.

The scientific communication is suffering considerable alterations so much in its process as in its structure and philosophy. The open archives and open access initiatives are contributing significantly for the undoing of the traditional model of scientific communication and for the construction of a new disaggregated model and with interoperability, fairer and efficient to disseminate the research results and like this, the knowledge generated by the scientific communities. However, due to the progresses of the information and communication technologies, not only the structure and the flow of the scientific communication is suffering considerable alterations, as well as the own concept and support of the scientific documents. This has been generating the need of the development of tools to optimize the organization, description, exchange and information retrieval processes, besides the digital preservation, among others. Highlight that the MARC format it has been allowing per decades the description and the exchange of bibliographical and cataloging registrations to the institutions, favoring the access to the contents informacionais contained in several collections. However, with the exponential growth of information and of the documents generation (above all digital), this has been demanding larger flexibility and interoperability among the several information systems available. In this scenery, the XML markup language is presented as one of the current developments that has as purpose to facilitate and to optimize the administration, storage and transmission of contents through Internet, it being incorporate for several sections and areas of the knowledge for the handling easiness and operational flexibility. Front to that, an exploratory study of theoretical analysis was accomplished, identifying the adaptation of the MARCXML format in the construction in ways of descriptive representation for information resources in open archives, as a complex and flexible standard of metadata, that will make possible the interoperability among information systems heterogeneous, besides the access to the information. As result of this research, It's considered that MARCXML is an appropriate format for description of data in a complex structure. It’s ended that the measure that increases the complexity of the documents in the repositories and open archives, plus it’s justified a structure of metadata, as the MARCXML format, that support the description of the pecificities of the informational resources, once this initiative is not and nor it will be if restricting to scientific documents, but expanding the other types of informational resources more and more complex and specific, also demanding an appropriate description for the specificities of the bibliographical entities.

The advent of the internet has revolutionized the way scientists communicate their research results increasing the power to disseminate and to access scientific production. This fact was responsible to restructure the scientific information flow that has incorporated its own characteristics from the digital culture. The Open Archives Initiative constituted the infrastructure that supports this restructuring. It was also responsible for the institutionalization of a model called e-prints repositories (ER), that stores, disseminates and promotes scientific production, published or not, in a place managed by the scientific community itself, that allows the inclusion of their public commmentaries about contents of that production. The hypothesis of this work suggests that the adherence to this model by the scientific communities depends on the level of understanding and acceptance, of the profile of the field interfering with the adoption of the innovation and its legitimation. Through a case study of Brazilian researchers from the Communication Sciences field it had been carried out the electronic focus group technique among 18 researchers, whose profile was formed by researches leaders registered at CNPq with backgroung in the field. The exploratory study identified many questions present in the dynamics of scientific communication of the field leading to proof of the hypothesis. From among results, distinguish low perception of that this model optimized the scientific information flow and strong tendency to not accept the model becauce of field profile. In conclusion, the level of adherence to the model is inserted in a medium to low scale.

La presente investigación tiene como objetivo determinar la influencia del marketing de contenidos dentro del proceso de decisión de compra del cliente de telefonía móvil. Para cumplir con dicho objetivo, se usó como objeto de estudio al blog de una empresa de telecomunicaciones en el Perú. A partir de ello, el estudio plantea una fase inicial de exploración para poder conocer a profundidad los conceptos del marketing de contenidos así como los cambios en el proceso de decisión de compra del cliente. En ese sentido, se elaboró un marco teórico que permitiera conocer a detalle las etapas que componen a cada eje conceptual. Posteriormente, de manera descriptiva, se realizó el estudio de un caso en particular que permite aterrizar los conceptos revisados para la investigación y a la vez, analizar la estrategia de contenidos dentro del proceso de decisión de compra del cliente. A través de este análisis, en primer lugar, se puede conocer específicamente cuáles han sido los resultados más influyentes producto de la aplicación de la estrategia, a fin de conocer los beneficios que trae adoptar la estrategia digital de contenidos; y, en segundo lugar, ver su participación en el proceso de decisión de compra del cliente. De esta forma, se podrá evidenciar si efectivamente esta estrategia va acorde con los objetivos de la misma. Como se ha mencionado anteriormente, se ha tomado como objetivo de estudio el blog de una empresa de telecomunicaciones en el Perú. La presente empresa se sitúa en una industria altamente competitiva lo cual ha demandado cambios en los lineamientos estratégicos del área de marketing a partir de la entrada de nuevos competidores. Debido a ello, es que la empresa decidió buscar nuevas estrategias que le permita sobrellevar los cambios en la industria y ofrecer un valor agregado a sus clientes. Como resultado del estudio se exponen, en primer lugar, los hallazgos relativos a la participación del blog en estudio en cada una de las etapas del proceso de decisión de compra desde el punto de vista de quienes diseñan y ejecutan la estrategia, y de los clientes del mismo. Posteriormente, los hallazgos encontrados sirvieron como base para proponer recomendaciones para mejorar el desempeño de la herramienta digital de contenidos, aprovechar las oportunidades de mejora y afianzar las fortalezas determinadas en el análisis. Finalmente, se presentan las conclusiones, las cuales comprenden todo el estudio de investigación.
Tesis

The evolution of scholarly documentation is discussed in light of the theory of the "ecology of documentation". The OAI-PMH is presented, and a survey of features found in existing service providers/overlays is presented. A prototype overlay incorporating features of wikis and "tagging" is presented along with some thoughts on how overlays may evolve and differentiate in the future.

The theoretical part of this thesis consists of the description of technical standards and the legal conditions for the publishing of e-theses in Austria. The practical part analyses the state of the art of e-thesis publication in Austria. Interviews by telephone and email were the applied methods. Two international e-theses portals were examined. Together with the results of the interviews a good practice modell for all Austrian universities was developed.

All the aspects of scientific communication are explained. An analysis of the impact of the movement for open access to scientific and academic literature was performed: here you will find a full description of its beginnings, definitions of the main terms, goals, the most significant initiatives undertaken all around the world and those strategies designed to get it; the open access journals and self-archiving in repositories - focusing on the progress of the latter – represent the most radical alternative for the development of open access. Then the different practices and attitudes adopted by Argentine librarians towards the self-archiving of their work in the thematic repository E-Lis are also analyzed. We try to determine which factors contribute to the use or non use of the repository.

The Federal Institutions of Higher Education in Brazil can give more transparency to the financial resources allocated to science development by providing various information sources in its repositories. The purpose was analyzed the policies and information sources from Institutional Repositories from the Federal Institutions of Higher Education. Also identified those federal institutions of higher education that keep institutional repositories policies, identification of typology about information sources and established policies and made it available for users. It was adopted the basic research methodology, from the point of view of its nature, and descriptive, because of its form of object study. The descriptive research was developed as documentary research supported on the bibliographical research to contextualizing the matter, getting qualitative character. The research‟s universe was formed by the 97 Federal Institutions of Higher Education in Brazil, knowing that the scientific research, that was performed in these institutions, aim for the constant improvement of the products and services to the internal and external users. These institutions, 57 are federal universities, 38 are federal institutes and 02 are federal centers of technical education. The population of survey is formed for 23 institutions that keep repositories and the sample is formed for 07 institutions that keep repositories with instituted policies made available for users. It was concluded that the Institutional Repositories present information primary and secondary sources. The repositories that have only primary sources are 71,42%; 28,58% of the IRs, besides of presenting primary sources, presents secondary sources as well. It was not observed tertiary sources. The information sources considered relevant by FIHE to fill up of repositories were: thesis and dissertation; journal‟s articles; papers presented at events; final project in graduation; photographic collection; final project in postgraduation; documents (minutes); books; books chapters, and basics references for newspapers news. The study allowed the federal institutions of higher education knew the information sources used in its repositories, because the policies made the organization and the dissemination easy, that brings benefits to the scientific and institutional community and to the society in general, including the Information Science area.

The reason that the work has is to show how technologies can be support in the automation and innovation of libraries, in how the implementation of an electronic book manager allows the conservation, consultation and recovery of a collection allowing to protect knowledge created in a higher level institution.