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Publié le 11 mars 2023

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Articles de revues sur le sujet "HPS-9"

Colby, Thomas V., Sherif R. Zaki, Richard M. Feddersen et Kurt B. Nolte. « Hantavirus Pulmonary Syndrome Is Distinguishable From Acute Interstitial Pneumonia ». Archives of Pathology & ; Laboratory Medicine 124, n^o 10 (1 octobre 2000) : 1463–66. http://dx.doi.org/10.5858/2000-124-1463-hpsidf.

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Abstract Context.—Hantavirus pulmonary syndrome (HPS) and acute interstitial pneumonia (AIP) can share similar clinical presentations. AIP is an acute, diffuse lung disease that has some clinical features suggesting a viral infection, although causative agent(s) have not been identified. Objective.—To clinically, histologically, and immunohistochemically compare cases of HPS to cases of AIP and to determine if any cases of AIP were actually examples of HPS. Design.—Seven cases of HPS and 9 cases of AIP were compared clinically and histologically by semiquantitative grading of features in lung tissue. The cases were also evaluated immunohistochemically for the presence of hantaviral antigens. Results.—Hantavirus pulmonary syndrome had a shorter clinical duration and more acute changes histopathologically; AIP was of longer clinical duration and was usually accompanied by histologic evidence of organization. Hantavirus pulmonary syndrome was distinguished by the presence of immature leukocytes in the pulmonary vasculature. No hantaviral antigens were identified immunohistochemically in the 9 case of AIP. Hantaviral antigens were identified in all 7 cases of HPS. Conclusion.—Cases of AIP and fatal cases of HPS can generally be distinguished on clinical and histologic grounds, and this distinction can be further confirmed immunohistochemically.

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Marrero Torres, R., S. Coste-Sibilia, H. Nieves-Jimenez, G. Torres, E. Rivera et E. A. Torres. « P360 Aggressive Inflammatory Bowel Disease is associated to Hermansky-Pudlak Syndrome : Characterization of a Puerto Rican Cohort ». Journal of Crohn's and Colitis 15, Supplement_1 (1 mai 2021) : S379—S380. http://dx.doi.org/10.1093/ecco-jcc/jjab076.484.

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Abstract Background Hermansky-Pudlak Syndrome (HPS), a rare autosomal recessive disorder, is the most common single-gene disorder in Puerto Rico. It is characterized by an aberrant biogenesis of lysosome-related organelles inducing oculocutaneous albinism, bleeding diathesis, and damage to other organs. Around 30% of patients with HPS develop granulomatous enterocolitis, a Crohn’s-like inflammatory bowel disease (IBD). The mutant HPS1 gene is associated with a more severe Early Onset IBD (EO-IBD). We wish to describe a group of patients with HPS-associated IBD. Methods Puerto Ricans with HPS and concomitant IBD were recruited in our IBD clinic for a prospective cohort study. After informed consent, demographic and medical data were collected from the patient and the medical record. Variables included sex, HPS genotype, age at the time of IBD diagnosis, IBD location and behavior according to Montreal and Paris Classification, surgical interventions, medications, and extra-intestinal manifestations (EIM). Descriptive analysis was performed calculating mean and standard deviations. This study is approved by the MSC IRB. Results 13 patients with HPS and IBD, 9 with confirmed genotype 1, were identified: 8 males and 5 females. The mean age at the time of IBD diagnosis was 22 ± 11 years. 6 were diagnosed at ≤ 16 y/o (A1), 6 were diagnosed between 17-40 years (A2) and 1 patient was in the range of EO-IBD (7 y/o). 9 patients had advanced penetrating behavior (B3) of which 7 had concomitant perianal involvement. Most patients (9) had a surgical intervention; 8 have an ostomy. The majority (10) are using biologics (4 with concurrent immunomodulators). The most frequent EIM was peripheral arthropathy seen in 45%. Conclusion HPS patients had a severe course of IBD, as shown by age at diagnosis, phenotype, the prevalence of perianal disease, surgery and use of biologics. In comparison to a database of 836 Puerto Ricans with non HPS Crohn’s Disease, those with HPS were more likely to have surgeries (69% vs 55%, P=.303) and use biologics (77% vs 43%, P=.015). Gastrointestinal symptoms including bleeding may be overlooked by the primary physician. Proactive vigilance in patients with HPS to make an early diagnosis of IBD and aggressive medical treatment may result in better outcomes for these patients.

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Wang, Chun Sheng, Lan Duan, Ming Wei et Li Xiang Liu. « The Mechanics Behavior Tests of HPS-485W Made in China ». Advanced Materials Research 146-147 (octobre 2010) : 1506–9. http://dx.doi.org/10.4028/www.scientific.net/amr.146-147.1506.

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This paper gives a brief introduction of the developmental history of high performance steel (HPS) all over the world. Emphasis of current paper is on the characteristic studies of HPS 485W, which is new structural weathered steel produced by Wuyang Steel Iron Company using quenching and tempering (Q&T) in China. To obtain the strength and ductility of HPS 485W, the tensile coupons were machined from each 8mm, 10mm, 12mm and 14mm thick plate. Based on the static tensile tests in room temperature, major of material mechanical characters were obtained, such as yield strength, ultimate strength, elastic modulus and so forth. Besides, to examine plate toughness, 30 Charpy V-Notch (CVN) specimens from 12mm thick HPS 485W plate were tested from 20 oC to -196 oC . Compared with conventional bridge steels, the CVN test results show that the fracture toughness of HPS 485W is much higher, and the brittle-ductile transition of HPS occurs at a much lower temperature. A set of 9 single-edge bend specimens were took from 20mm and 30mm thick HPS 485W separately for ductility fracture toughness test. The calculated JIC value is 415.8 kJ/m2 for 18mm thick specimen and 507.79 kJ/m2 for 28mm thick specimen, which shows ideal ductility of HPS 485W.

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Maldonado, Enrique F., Francisco J. Fernandez, M. Victoria Trianes, Keith Wesnes, Orlando Petrini, Andrea Zangara, Alfredo Enguix et Lara Ambrosetti. « Cognitive Performance and Morning Levels of Salivary Cortisol and α-Amylase in Children Reporting High vs. Low Daily Stress Perception ». Spanish Journal of Psychology 11, n^o 1 (mai 2008) : 3–15. http://dx.doi.org/10.1017/s1138741600004066.

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The aim of the present study was to assess the effects of daily stress perception on cognitive performance and morning basal salivary cortisol and alpha-amylase levels in healthy children aged 9–12. Participants were classified by whether they had low daily perceived stress (LPS,n= 27) or a high daily perceived stress (HPS,n= 26) using the Children Daily Stress Inventory (CDSI). Salivary cortisol and alpha-amylase were measured at awakening and 30 minutes later. Cognitive performance was assessed using the Cognitive Drug Research assessment system. The HPS group exhibited significantly poorer scores on speed of memory (p < .05) and continuity of attention (p< .05) relative to the LPS group. The HPS group also showed significantly lower morning cortisol levels at awakening and at +30 minutes measures in comparison with the LPS group (p< .05), and mean morning cortisol levels were negatively correlated with speed of memory (p< .05) in the 53 participants. No significant differences were observed between both groups in alpha-amylase levels. These findings suggest that daily perceived stress in children may impoverish cognitive performance via its modulating effects on the HPA axis activity.

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Bin Pet, Mokhtar, et Ahmad Johari Hj Sihes. « Relationship Domain of Form Six Teachers Thinking in Teaching with External Factors of Form Six Teachers ». International Journal of Evaluation and Research in Education (IJERE) 4, n^o 1 (1 mars 2015) : 1. http://dx.doi.org/10.11591/ijere.v4i1.4485.

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<table class="MsoNormalTable" style="width: 444.85pt; border-collapse: collapse; border: none; mso-border-alt: solid windowtext .5pt; mso-yfti-tbllook: 1184; mso-padding-alt: 0cm 5.4pt 0cm 5.4pt; mso-border-insideh: .5pt solid windowtext; mso-border-insidev: .5pt solid windowtext;" border="1" cellspacing="0" cellpadding="0" width="593"><tbody><tr style="mso-yfti-irow: 0; mso-yfti-firstrow: yes; mso-yfti-lastrow: yes; height: 63.4pt;"><td style="width: 290.6pt; border: none; border-top: solid windowtext 1.0pt; mso-border-top-alt: solid windowtext .5pt; padding: 0cm 5.4pt 0cm 5.4pt; height: 63.4pt;" width="387" valign="top">This study aimed to examine the external factors of form six teachers who can influence thinking domain form six teachers in their teaching. This study was conducted using a quantitative approach using questionnaires. A total of 300 form six teacher schools in Johor were chosen as respondents. The findings were obtained as student background factors are the most important factors that influence the thinking domain of form six teachers with a mean value of 4.54 and the domain of thinking is that teachers' expectations domain is the most important with the 4:54. Relation to external factors form six teachers with thinking domain form six teachers in the teaching of significant positive classroom atmosphere factors with r = .524, school goals with r = .405, needs of students with r = .454 and students background with r = .423. This study will help the Ministry of Education to raise the standards of form six education. </td></tr></tbody></table>

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SILVERIO, Americo de Oliveira, Dayanne Cintra GUIMARAES, Larissa Fernanda Queiroz ELIAS, Erika Oliveira MILANEZ et Silvano NAVES. « ARE THE SPIDER ANGIOMAS SKIN MARKERS OF HEPATOPULMONARY SYNDROME ? » Arquivos de Gastroenterologia 50, n^o 3 (septembre 2013) : 175–79. http://dx.doi.org/10.1590/s0004-28032013000200031.

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Context Hepatopathies can significantly influence both veins and arteries, these changes may cause some cutaneous stigmas, such as spider angioma (SA) and some systemic vascular changes, such as those observed in hepatopulmonary syndrome (HPS). Based on this common pathophysiological root we can assume that the SA can be skin markers of HPS. Objective The objective of this study is to assess whether there is a relationship between the presence of SA and HPS. Methods Records of 40 patients with liver cirrhosis who underwent contrast echocardiography were evaluated, in which we researched the description of SA, physical examination, and other clinical and laboratory data. For diagnosis of HPS we use these signs of the disease: presence of liver disease (cirrhosis in the case), abnormalities in gas exchange by arterial blood gases, and evidence of pulmonary vasodilations by the contrast echocardiography. Results The SA were found in 21/40 (52.5%) patients and hepatopulmonary syndrome in 9/40 (22.5%). The HPS was observed in 8/21 (38.1%) of patients with SA and 1/19 (5.3%) patients were without this sign (P<0.01). We found no statistically significant difference between the SA and the presence of HPS with sex or age. Patients with SA had a higher hypoxemia [PaO2 84.8 ± 11.5 mmHg and 19.8 ± 14.7 mmHg alveolar-arterial gradient of oxygen (AAG)] than those without SA (PaO2 90.8 ± 10.7 mmHg and 10.9 ± 11.7 AAG mmHg) (P<0.05). Conclusion Our findings show a correlation between the presence of SA and HPS, suggesting that the SA may be cutaneous markers of HPS.

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Johnson, Benny, Smith Giri, Sara E. Nunnery, Eric Wiedower, Omer Jamy, Jason C. Chandler et Mike G. Martin. « Comorbidities Drive Outcomes for Both Malignancy and Non-Malignancy Associated Hemophagocytic Syndrome ». Blood 126, n^o 23 (3 décembre 2015) : 3261. http://dx.doi.org/10.1182/blood.v126.23.3261.3261.

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Abstract Background Secondary hemophagocytic syndrome (HPS), also known as hemophagocytic lymphohistiocytosis (HLH), is a rare syndrome that develops in the context of infection, autoimmune disease or an underlying malignancy. This results in the unregulated activation of the immune system and an aberrant proliferation of histiocytes and hemophagocytosis. Most of what is clinically known about secondary HPS/HLH is from case reports and case series. We studied the predictors of mortality among adults admitted with HPS with or without an associated malignancy using a large national inpatient database. Patients and Methods Cases of HPS were identified from the Nationwide Inpatient Sample (NIS) 2009-2011 using International Classification of Diseases-9th revision Clinical Modification (ICD-9-CM) codes 288.4 for primary or secondary diagnosis combined with bone marrow examination procedure code (41.31). Cases of malignancy were identified by using ICD-9-CM codes 104-208.9 and the use of inpatient chemotherapy was defined by ICD-9-CM procedure codes 9925 and 8607. Comorbidity assessment was done using Deyo modification of Charlson comorbidity index which takes into account 17 ICD based comorbidities. Malignancy was excluded from co-morbidity assessment. The impact of various patient/hospital related factors on mortality was first assessed using chi-square test or Analysis of Variance (ANOVA). Factors with p value 0.01 or less on bivariate analysis were then subjected to multivariate analysis using logistic regression methods. Statistical analysis was done using STATA 13.0 (StataCorp LP, College Station,TX). All p values were two sided and the level of significance was 0.05. Results A total of 276 patient hospitalizations with HPS were identified. Forty-four had an associated malignancy, out of which 38 (86%) were hematologic. The other cases were associated with systemic lupus erythematosus (n=12; 5%), rheumatoid arthritis (n=21; 9%), histoplasmosis (n=3;1.3%) or HIV (n=1; 0.4%). The median age was 42 (range 18-89 years) and 43% (n=114) were females. A total of 66% (n=182) had Charlson index (CI) of 0, whereas 13% (n=27) had a CI of 1 and 21% (n=57) had a CI of 2 or more. On bivariate analysis, the inpatient mortality rate was significantly higher in malignancy associated HPS (OR 2.07; P =0.04), age ≥ 50 (OR 3.46; P <0.01), CI > 2 (OR, 3.04; P <0.01), and patients with Medicare (OR 2.32; P <0.01). However, there was no statistically significant difference in mortality based on the receipt of chemotherapy (P= 0.90), hospital region i.e. rural versus urban (P=0.43) and teaching status (P= 0.71). In multivariate analysis, CI ≥ 2 remained an independent predictor of survival in the overall study cohort (OR 3.52; 95% CI 1.51-8.18; P <0.01). Conclusion In this large series of adults with HPS, patients with malignancy associated HPS, CI ≥ 2, age> 50, and Medicare patients were associated with a worse in-hospital mortality. In multivariate analysis, patients with a greater co-morbidity burden appeared to be the single most important predictor of mortality. This suggests that outcomes for HPS are predicated by the extent of organ dysfunction at diagnosis. Disclosures No relevant conflicts of interest to declare.

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Ohyagi, Hideaki, Nobuyuki Onai, Yong-Mei Guo, Naoto Takahashi, Makoto Hirokawa, Ken-Ichi Sawada et Toshiaki Ohteki. « Prevention of Hemophagocytosis by TNF-α and IL-6 Blockade in TLR9- and Nod1- Ligand Induced Hemophagocytic Syndrome. » Blood 114, n^o 22 (20 novembre 2009) : 1351. http://dx.doi.org/10.1182/blood.v114.22.1351.1351.

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Abstract Abstract 1351 Poster Board I-373 Introduction Hemophagocytic syndrome (HPS, also referred as hemophagocytic lymphohistiocytosis; HLH) is a life-threatening condition caused by hyperinflammatory response. It can be classified into familial and acquired forms. Familial HPS is a disorder inherited in an autosomal recessive or X-linked manner. Several loci and genes have been implicated in the familial HPS, including perforin, or cytotoxic granule exocytosis genes. While, acquired (secondary) HPS is a sporadic syndrome occurring in association with systemic infection (virus, bacteria, protozoa, and fungi), underlying malignancy, or immunodeficient disorder. The central pathophysiologic abnormality in HPS is cytokine dysfunction, resulting in uncontrolled accumulation of activated T-lymphocytes and activated histiocytes (macrophages) in many organs. Several cytokines including interferon-γ, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-10, IL-12, and soluble IL-2 receptor (sCD25), found at extremely high levels in the plasma of HPS patients. Treatment of hemophagocytic lymphohistiocytosis is based on epipodophyllotoxin derivatives, etoposide, corticosteroids, cyclosporin A, antithymocyte globulin (ATG), and, in selected patients, intrathecal methotrexate. Recently, anti-TNF-α therapy has been reported to prove patients with refractory HPS, however, there is not enough evidence. In this study, we established murine HPS model by intravenous injection of CpG oligodeoxynucleotide (ODN)-1668, a ligand for Toll-like receptor 9 (TLR9) and combination of CpG and iE-DAP, which is a ligand for Nod1, and investigated the role of TNF-α and other cytokine in HPS model. Methods C57BL/6J mice were injected intravenously with 200 μg of CpG or combination of CpG and 100 μg of iE-DAP. The treated mice were assayed for temperature, spleen weight, and complete blood count. The serum cytokines levels (TNF-α and IL-6) and triglycerides were determined by ELISA and auto-analyzer, resectively. Hemophagocytosis was determined by flow cytometric (FCM) analysis in the peripheral blood and spleen. The spleen was subjected into immunohistochemistry staining and histological examination. For TNF-α and IL-6 blockade, the mice were treated with TNF receptor (TNFR)-Fc (etanercept) or combination of TNFR-Fc and anti-mouse IL-6 receptor (IL-6R) monoclonal antibody (MR16-1) by intravenous injection. Results CpG injected mouse displayed the typical HPS clinical criteria, such as, fever, cytopenia, splenomegaly, hemophagocytosis in the peripheral blood and spleen. Furthermore, elevations of inflammatory cytokines (TNF-α and IL-6) and triglyceride were detected in the serum of these mice. These clinical symptoms were not observed in CpG-injected TLR2−/−4−/−9−/− mice and LPS-injected wild type mice. Interestingly, combination challenge of CpG and iE-DAP led to synergistic induction of hemophagocytosis and enhanced production of TNF-α and IL-6 in the serum, however, single iE-DAP challenge did not induce HPS. FCM analysis revealed that monocyte-derived dendritic cells, which were CD11b, Ly6c, and F4/80, were mobilized and engulfed TER119+ erythrocyte in the peripheral blood and spleen after these challenge. Treatment of mice with TNFR-Fc partially prevented, and combination of TNFR-Fc and anti IL-6R mAb markedly suppressed hemophagocytosis in the peripheral blood and spleen. Conclusions: Based on these results, CpG or CpG + iE-DAP-induced mouse HPS model is valuable to study for cellular and molecular mechanism of HPS development, and potential system to apply preclinical research. Furthermore, prevention of both TNF-α and IL-6 might represent a novel therapy for HPS. Disclosures No relevant conflicts of interest to declare.

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Gelderman-Fuhrmann, Monique, Xuan Chi, Li Zhi et Jaroslav Vostal. « UVB Light Exposed Human Platelets Mediate Acute Lung Injury In a Two-Event Mouse Model of Transfusion ». Blood 116, n^o 21 (19 novembre 2010) : 3354. http://dx.doi.org/10.1182/blood.v116.21.3354.3354.

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Abstract Abstract 3354 Transfusion related acute lung injury (TRALI) has occurred in patients whose underlying condition led to an inflamed endothelium, and who were transfused with a transfusion product that contained either HLA or HNA antibodies or biologic modifiers such as lipids or antigens from stored cells. Similar two-event reactions can be modeled in animals pretreated with lipopolysaccharide (LPS) and infused with similar types of antibodies or media from stored transfusion products. The first event induces activation of the endothelium and sequestration of neutrophils in the lungs while the second event activates neutrophils to cause local tissue damage. In some animal models of acute lung damage platelet depletion reduces the lung damage while in other models infusion of activated platelets potentiates it. Ultraviolet B (UVB) light has been used on platelet transfusion products to prevent alloimmunization or with chemical sensitizers to reduce pathogens. Such processing may damage platelets and potentiate their storage lesion. UVB exposed human platelets (HPs) were evaluated in a two-event animal model of acute lung injury (ALI) where the sensitizing event was LPS and the second event was infusion of HPs or UVB HPs (2.4 J/cm2). Immunodeficient (SCID) mice were used to minimize the species difference (Piper et al., Transfusion 47:1540-9, 2007). UVB exposure of HPs increased their p-selectin expression (control 17.8±0.3% vs. UVB 35.9±3.2%) and reduced their JC-1 dye ratio indicating mitochondrial damage (8.9±0.7 control vs 1.9±1.2 UVB). Internal organ distribution of intravenous (IV) infused HPs was followed with whole animal imaging, confocal microscopy and with pathophysiological changes in bronchoalveolar lavage fluid (BALF). In LPS-treated mice, UVB HPs labeled with fluorescent dye had more accumulation in lungs compared to untreated HPs (29±12% vs 15±5% respectively; % of total fluorescence recovered), while the accumulation in lungs of healthy animals was equivalent for both UVB treated and untreated HPs. In separate experiments, LPS pretreated mice were infused with UVB exposed HPs or control HPs, and lungs were examined by histology and with confocal microscopy for fluorescent staining for CD41 and CD62 expression. Histology sections revealed extensive changes in lungs, such as thickening of the alveolar septa and obliteration of lung architecture in LPS animals infused with UVB HPs as compared to healthy animals infused with control HPs or with HPs treated with UVB. Confocal microscopy with specific antibodies identified HP accumulation in lungs of LPS treated animals infused with UVB exposed HPs. However, HP accumulation in lungs did not occur with control HPs or in healthy mice. Accumulation of UVB HPs in lungs of LPS pretreated mice was associated with increased (3-4 fold compared to control HPs) protein concentration and leukocyte accumulation in BALF. Increased alveolar permeability to protein and leukocyte accumulation in alveoli is associated with acute lung damage. To examine whether lung damage occurred due to presence of UVB HPs in the lungs or due to biologic mediators released into plasma from UVB exposed HPs we separated plasma from HPs post UVB treatment and infused the UVB plasma alone. Plasma isolated from UVB HPs did not alter BALF protein levels or leukocyte counts even though the UVB HPs did. In conclusion, UVB HPs can accumulate in lungs of LPS primed animals and are associated with lung damage as indicated by histological changes and increased protein and WBCs in BALF fluid. The ALI is associated with direct platelet accumulation in the lungs but not with biologic modifiers released into plasma. Our animal model of ALI suggests that HPs exposed to high doses of UVB could mediate similar effects in patients predisposed to TRALI with sepsis or other causes of endothelial cell inflammation. The findings and conclusions in this abstract have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any Agency determination or policy. Disclosures: No relevant conflicts of interest to declare.

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O’Lone, Emma, Martin Howell, Andrea K. Viecelli, Jonathan C. Craig, Allison Tong, Benedicte Sautenet, William G. Herrington et al. « Identifying critically important cardiovascular outcomes for trials in hemodialysis : an international survey with patients, caregivers and health professionals ». Nephrology Dialysis Transplantation 35, n^o 10 (10 février 2020) : 1761–69. http://dx.doi.org/10.1093/ndt/gfaa008.

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Abstract Background Cardiovascular disease (CVD) is a major contributor to morbidity and mortality in people on hemodialysis (HD). Cardiovascular outcomes are reported infrequently and inconsistently across trials in HD. This study aimed to identify the priorities of patients/caregivers and health professionals (HPs) for CVD outcomes to be incorporated into a core outcome set reported in all HD trials. Methods In an international online survey, participants rated the absolute importance of 10 cardiovascular outcomes (derived from a systematic review) on a 9-point Likert scale, with 7–9 being critically important. The relative importance was determined using a best–worst scale. Likert means, medians and proportions and best–worst preference scores were calculated for each outcome. Comments were thematically analyzed. Results Participants included 127 (19%) patients/caregivers and 549 (81%) HPs from 53 countries, of whom 530 (78%) completed the survey in English and 146 (22%) in Chinese. All but one cardiovascular outcome (‘valve replacement’) was rated as critically important (Likert 7–9) by all participants; ‘sudden cardiac death’, ‘heart attack’, ‘stroke’ and ‘heart failure’ were all rated at the top by patients/caregivers (median Likert score 9). Patients/caregivers ranked the same four outcomes as the most important outcomes with mean preference scores of 6.2 (95% confidence interval 4.8–7.5), 5.9 (4.6–7.2), 5.3 (4.0–6.6) and 4.9 (3.6–6.3), respectively. The same four outcomes were ranked most highly by HPs. We identified five themes underpinning the prioritization of outcomes: ‘clinical equipoise and potential for intervention’, ‘specific or attributable to HD’, ‘severity or impact on the quality of life’, ‘strengthen knowledge and education’, and ‘inextricably linked burden and risk’. Conclusions Patients and HPs believe that all cardiovascular outcomes are of critical importance but consistently identify sudden cardiac death, myocardial infarction, stroke and heart failure as the most important outcomes to be measured in all HD trials.

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Thèses sur le sujet "HPS-9"

Prandini, Alberto. « Identificazione e caratterizzazione di una nuova sindrome da immunodeficienza primaria associata ad albinismo oculocutaneo ». Doctoral thesis, Università degli studi di Trieste, 1985. http://hdl.handle.net/10077/8569.

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2011/2012
La sindrome di Hermansky-Pudlak definisce un gruppo di immunodeficienze primarie rare caratterizzate da albinismo parziale, di tipo autosomico recessivo che si presentano con un quadro di infezioni ricorrenti e predisposizione ad emorragie. I geni causativi di queste patologie codificano proteine coinvolte nella biogenesi e nel trasporto di organelli intracellulari correlati a endosomi e lisosomi. Il caso giunto alla nostra attenzione presentava solo alcuni dei sintomi caratteristici di queste immunodeficienze. Escluse le malattie genetiche più note tramite sequenziamento diretto si è ricorso ad exome sequencing in modo da poter rilevare anche nuove variazioni non note. E' stata infatti riscontrata una mutazione in omozigosi sul gene PLDN (BLOC1S6), codificante una proteina chiamata Pallidina, una componente del complesso BLOC-1. La condizione risultante è stata identificata con il nome di “sindrome di Hermansky-Pudlak di tipo 9” (HPS-9). In questo studio dimostriamo che tale mutazione è associata alla patologia e che compromette la funzionalità del reparto immunitario sia citotossico (linfociti Natual Killer e CD8+) sia presentante l'antigene (cellule dendritiche).
XXV Ciclo

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Bütow, Carolin Verena [Verfasser]. « Expression der Carboanhydrase 9 bei HPV-assoziierten und HPV-negativen Plattenepithelkarzinomen des Oropharynx im Hinblick auf eine Hypoxie-Signalwegs-Aktivierung / Carolin Verena Bütow ». Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1223461920/34.

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Bütow, Carolin [Verfasser]. « Expression der Carboanhydrase 9 bei HPV-assoziierten und HPV-negativen Plattenepithelkarzinomen des Oropharynx im Hinblick auf eine Hypoxie-Signalwegs-Aktivierung / Carolin Verena Bütow ». Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1223461920/34.

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Nunes, Rafael Enrique [UNESP]. « Argilas modificadas : remoção de antraceno e ácido 9-antróico como modelo para aromáticos (hpa) presentes em águas ». Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/97787.

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Made available in DSpace on 2014-06-11T19:29:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-17Bitstream added on 2014-06-13T19:58:42Z : No. of bitstreams: 1 nunes_re_me_sjrp.pdf: 757996 bytes, checksum: a9d2dac5fa8e31e51dfe97f412131591 (MD5)
O presente trabalho está relacionado ao estudo da interação entre as argilas modificadas e compostos orgânicos aromáticos, visando à remoção destes por meio das propriedades de adsorção das argilas. As argilas foram submetidas aos processos de purificação, troca catiônica e também à técnica de pilarização. As propriedades obtidas, após os processos de modificações das argilas (microporosidade e adsorção de compostos orgânicos) foram analisadas no estudo da eficiência da adsorção dos compostos orgânicos, fazendo análises comparativas entre elas. Para análises, comparativas e caracterização das argilas, foram utilizadas as técnicas espectrofotométricas UV-Visível, Infravermelho, Difração de Raios X e Análise Térmica (TG-DTA simultâneos). As modificações constatadas foram: 1- a ocorrência da purificação com ácido clorídrico, troca catiônica (cátions Na+ natural das argilas) por cátions de Cu2+,Ca2+ e pilarização com íon Keggin (Al13); 2- aumento significativo da eficiência na adsorção dos compostos orgânicos antraceno e ácido 9-antróico em meio aquoso; 3- melhora da eficiência na adsorção dos compostos orgânicos aromáticos pelas argilas (KSF e STx-1) pilarizadas com o íon Keggin de alumínio (Al13), e 4 - melhora da adsorção, pelas argilas, do antraceno quando comparado ao ácido 9-antróico. As justificativas para as ocorrências descritas nos itens 3 e 4 foram: maior espaçamento basal das lamelas das argilas pilarizadas, maior caráter hidrofóbico e ausência do grupo carboxila, respectivamente. Os resultados mostraram ótima eficiência das argilas modificadas para a remoção dos compostos orgânicos (antraceno e ácido 9-antróico) presentes em água
This study is related to the study of interaction clays modified and organic aromatic compounds, aimed at removing these through the adsorption properties of clays. The clays were subjected to purification processes, and also the cation exchange technique pillarization. The properties obtained after the process of modification of clays (microporosity and adsorption of organic compounds) were analyzed to study the efficiency of adsorption of organic compounds, making comparative analysis between them. To comparative analyze and characterization of clays, spectrophotometric techniques were used UV-visible, infrared, X ray diffraction and thermal analysis (simultaneous TG-DTA). The changes observed were: 1 –the occurrence of purification with hydrochloric acid cation exchange (Na+ cations of natural clays) by cations Cu2 + and Ca2 + and pillarization with Keggin ion (Al13); 2 - significant increase in efficiency in the adsorption of organic compounds anthracite and 9-antróico acid in aqueous medium; 3 - improving the efficiency of adsorption of aromatic organic compounds by clays (KSF and STx-1) pillared with aluminum Keggin ion; 4 - improvement of adsorption by clays, anthracite compared to 9-antroico acid. The reasons for the occurrences described in items 3 and 4 were higher basal spacing of the lamellae of the pillared clays, the greater hydrophobic character and absence of the carboxyl group, respectively. The results showed great efficiency of modified clays for the removal of organic compounds (anthracite and 9-antroico acid) present in water

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Nunes, Rafael Enrique. « Argilas modificadas : remoção de antraceno e ácido 9-antróico como modelo para aromáticos (hpa) presentes em águas / ». São José do Rio Preto : [s.n.], 2011. http://hdl.handle.net/11449/97787.

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Orientador: Fernando Luis Fertonani
Banca: Cecília Cristina Marques dos Santos
Banca: Márcia Cristina Bisinoti
Resumo: O presente trabalho está relacionado ao estudo da interação entre as argilas modificadas e compostos orgânicos aromáticos, visando à remoção destes por meio das propriedades de adsorção das argilas. As argilas foram submetidas aos processos de purificação, troca catiônica e também à técnica de pilarização. As propriedades obtidas, após os processos de modificações das argilas (microporosidade e adsorção de compostos orgânicos) foram analisadas no estudo da eficiência da adsorção dos compostos orgânicos, fazendo análises comparativas entre elas. Para análises, comparativas e caracterização das argilas, foram utilizadas as técnicas espectrofotométricas UV-Visível, Infravermelho, Difração de Raios X e Análise Térmica (TG-DTA simultâneos). As modificações constatadas foram: 1- a ocorrência da purificação com ácido clorídrico, troca catiônica (cátions Na+ natural das argilas) por cátions de Cu2+,Ca2+ e pilarização com íon Keggin (Al13); 2- aumento significativo da eficiência na adsorção dos compostos orgânicos antraceno e ácido 9-antróico em meio aquoso; 3- melhora da eficiência na adsorção dos compostos orgânicos aromáticos pelas argilas (KSF e STx-1) pilarizadas com o íon Keggin de alumínio (Al13), e 4 - melhora da adsorção, pelas argilas, do antraceno quando comparado ao ácido 9-antróico. As justificativas para as ocorrências descritas nos itens 3 e 4 foram: maior espaçamento basal das lamelas das argilas pilarizadas, maior caráter hidrofóbico e ausência do grupo carboxila, respectivamente. Os resultados mostraram ótima eficiência das argilas modificadas para a remoção dos compostos orgânicos (antraceno e ácido 9-antróico) presentes em água
Abstract: This study is related to the study of interaction clays modified and organic aromatic compounds, aimed at removing these through the adsorption properties of clays. The clays were subjected to purification processes, and also the cation exchange technique pillarization. The properties obtained after the process of modification of clays (microporosity and adsorption of organic compounds) were analyzed to study the efficiency of adsorption of organic compounds, making comparative analysis between them. To comparative analyze and characterization of clays, spectrophotometric techniques were used UV-visible, infrared, X ray diffraction and thermal analysis (simultaneous TG-DTA). The changes observed were: 1 -the occurrence of purification with hydrochloric acid cation exchange (Na+ cations of natural clays) by cations Cu2 + and Ca2 + and pillarization with Keggin ion (Al13); 2 - significant increase in efficiency in the adsorption of organic compounds anthracite and 9-antróico acid in aqueous medium; 3 - improving the efficiency of adsorption of aromatic organic compounds by clays (KSF and STx-1) pillared with aluminum Keggin ion; 4 - improvement of adsorption by clays, anthracite compared to 9-antroico acid. The reasons for the occurrences described in items 3 and 4 were higher basal spacing of the lamellae of the pillared clays, the greater hydrophobic character and absence of the carboxyl group, respectively. The results showed great efficiency of modified clays for the removal of organic compounds (anthracite and 9-antroico acid) present in water
Mestre

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Mateescu, Bogdan. « Ciblage et régulation du facteur HP1 sur la chromatine ». Paris 6, 2006. http://www.theses.fr/2006PA066203.

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Chez les mammifères, le facteur HP1 (heterochromatin protein 1) est un acteur majeur dans les processus de formation et de régulation de la chromatine condensée. Le ciblage de HP1 sur la chromatine nécessite sa fixation sur la lysine 9 méthylée de l’histone H3 mais également la reconnaissance d’un ARN dont la nature reste à ce jour inconnue. Dans un premier temps, nous avons démontré que les modifications post-traductionnelles adjacentes à la lysine 9 de l’histone H3 (phosphorylation et acétylation) module la fixation de HP1 sur la chromatine. Par la suite nous avons montré que HP1 est impliqué dans le contrôle de la latence transcriptionnelle du virus VIH-1. Enfin, nous présentons des données suggérant que la machinerie d’ARN interférence et en particulier l’ARN viral TAR, sont impliqués dans le contrôle de la transcription du VIH-1. L’interaction potentielle entre HP1, machinerie d’ARN interférence et ARN TAR dans le control de la transcription du virus VIH-1 est discutée.

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Senatla, Kgola Tebogo. « Knowledge, attitudes and behaviour towards Human Papilloma Virus (HPV) and HPV vaccine among parents with adolescent girls 9 to 13 years in Sefhare, Botswana ». Diss., 2017. http://hdl.handle.net/10500/24353.

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Human papillomavirus (HPV) is the most common cause of sexually transmitted diseases. It is the causative agent of cervical cancer, anal, and penile cancers. The purpose of the study was to determine the knowledge, attitude and behaviour of parents towards HPV and HPV vaccine in preventing cervical cancer in girls aged 9 to 13 years and HPV vaccine uptake. The study was conducted in Sefhare village, in the Central District of Botswana. The researcher selected a quantitative, descriptive cross-sectional research design and data was collected using a questionnaire in face-to-face interviews. The study population consisted of parents of adolescent girls of ages 9-13 years living in four wards of Sefhare village. Data was analysed using SPSS version 19. The study found a high level (71.8%) of knowledge about HPV infection, cervical cancer and HPV vaccine and a positive attitude (81.5%) and behaviour (62%) towards the HPV vaccine.
Health Studies
M.P.H.

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Livres sur le sujet "HPS-9"

Workshop on High Performance Switching and Routing (2006 Poznań, Poland). 2006 Workshop on High Performance Switching and Routing : HPSR 2006 : Poznań, Poland, June 7-9 2006. Piscataway, NJ : IEEE, 2006.

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R, Stapper William, et Lewis Research Center, dir. Evaluation of navy 9 cst oil in Bell helicopter M412 HP gearboxes. [Cleveland, Ohio] : National Aeronautics and Space Administration, Lewis Research Center, 1998.

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Inc, ebrary, dir. HP Network Node Manager 9 : Getting started : manage your network effectively with NNMi. Birmingham, U.K : Packt Enterprise, 2011.

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Wigley, D. A. Machining-induced deformation in stepped specimens of PH 13-8 Mo, 18 nickel maraging steel grade 200TI and grain-refined HP 9-4-20 [microform]. Hampton, Va : National Aeronautics and Space Administration, Langley Research Center, 1985.

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Rannacher, Rolf, Hans Georg Bock, Xuan Phu Hoang et Johannes P. Schlöder. Modeling, Simulation and Optimization of Complex Processes - HPSC 2012 : Proceedings of the Fifth International Conference on High Performance Scientific Computing, March 5-9, 2012, Hanoi, Vietnam. Springer International Publishing AG, 2016.

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OWEN, Philip. Sweet 16 in Quarantine 16th Birthday Gift for Girls Ns HP Notebook : 120 Wide Lined Pages - 6 X 9 - College Ruled Journal Book, Planner, Diary for Women, Men, Teens, and Children. Independently Published, 2021.

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Chapitres de livres sur le sujet "HPS-9"

Nakao, Masahiro. « Mixed-Language Programming with XcalableMP ». Dans XcalableMP PGAS Programming Language, 147–63. Singapore : Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-7683-6_5.

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AbstractThis chapter presents the mixed-language programming with XcalableMP and other programming languages. It is supported by the linkage functions between XcalableMP and MPI library. We also demonstrate how to call XcalableMP program from Python program (M. Nakao et al., Linkage of XcalableMP and Python languages for high productivity on HPC cluster system, Proceedings of Workshops of HPC Asia, No .9, pp.39–47, 2018).

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Jongen, Johannes, Volker Kahlke et Tilman Laubert. « 9. Humanes Papilloma Virus (HPV) und anale intraepitheliale Neoplasie (AIN) ». Dans Manual der Koloproktologie, Band 1, sous la direction de Alexander Herold et Thomas Schiedeck, 137–52. Berlin, Boston : De Gruyter, 2019. http://dx.doi.org/10.1515/9783110614442-009.

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Onovo, Grace N. « Human Patient Simulations ». Dans Healthcare Ethics and Training, 452–80. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-2237-9.ch020.

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The relationship between self-efficacy (self-confidence) and anxiety levels, and the use of Human Patient Simulations (HPS) as a teaching-learning strategy, has not been sufficiently studied in the area of clinical nursing education. The purpose of this chapter is to evaluate the self-efficacy/self-confidence and anxiety levels in clinical skills performance of undergraduate nursing students, pre-use and post-use of Human Patients Simulations (HPS), as a teaching and learning strategy in maternity nursing. The study used a quantitative, pre-experimental, one group study design with a pretest and posttest experiment in data collection. The findings concluded that HPS reduced anxiety and increased self-efficacy/self-confidence in clinical skills performance and decision-making of the participants. In addition, the study found that the participants had difficulties in tasks performance with the following action verbs associated with the cognitive domain of Bloom's taxonomy. The verbs were “identify,” “apply,” and “analyze.”

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Dunlevy, Hillary. « “Doc, I think I have a hemorrhoid” ». Dans HIV, 111–18. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190088316.003.0014.

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Human papillomavirus (HPV) is a pervasive infection worldwide, with high rates of infection in people living with HIV. HPV lesions range from benign condyloma to precancerous and cancerous lesions in sites of anogenital and oropharyngeal HPV infection. The most effective prevention of infection, condylomas, precancerous lesions, and malignancy is through HPV vaccination, with recently expanded indications for 9-valent HPV vaccination up to age 45. Multiple modalities exist for treatment of anogenital condyloma, with high recurrence rates for most. For millions of people living with HIV, screening for premalignant lesions has been found to prevent HPV-related cervical cancer. Anal Papanicolaou testing and high-resolution anoscopy with biopsy are effective at identifying precancerous lesions. Treatment is available but has high rates of recurrence of HPV-related lesions. Studies are underway to help create guidelines for anal HPV lesion screening and cancer prevention.

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Laelago Ersado, Tariku. « Cervical Cancer Prevention and Control ». Dans Cervical Cancer - A Global Public Health Treatise [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99620.

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Cervical cancer is caused by HPV (human papilloma virus). It is the second most common cancer in women living low developed countries. The components of cervical cancer prevention and control comprises primary prevention, secondary prevention and tertiary prevention. Primary prevention of cervical cancer encompasses prevention of infection with HPV. Giving HPV vaccine for girls aged 9–14 years before they initiate sexual activity is one of the interventions of primary prevention of cervical cancer. Screening and treatment is needed in secondary prevention of cervical cancer. Screening of cervical cancer encompasses testing a target group (women) who are at risk for a cervical pre-cancer. Tertiary prevention of cervical cancer comprises treatment of cervical cancer and palliative care. The components of tertiary care comprise surgery, radiotherapy, chemotherapy and palliative care. Community mobilization, health education and counseling on cervical cancer prevention and control is vital to make ownership on cervical prevention. Monitoring and evaluation of cervical cancer prevention and control on key program indicators should be done regularly.

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Brabin, Loretta. « Chapter 9 Introduction of HPV prophylactic vaccination ». Dans Vaccines for the Prevention of Cervical Cancer. Oxford University Press, 2008. http://dx.doi.org/10.1093/med/9780199543458.003.0009.

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Mulry Baldwin, Celeste, et Lisa Rinke. « Preventing Human Papilloma Virus through Community Education and Vaccination ». Dans Cervical Cancer - A Global Public Health Treatise [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98350.

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Human Papilloma Virus (HPV) affects many members of the community. To better educate the community in a participatory manner, engaging those outside of the health care arena is necessary. To prevent the spread of the disease in the United States, reaching the parents of children at the vulnerable age of 9–11 years of age is critical. The barriers to education of parents and children around the spread of a sexually transmitted disease are vast and difficult to overcome. However, the use of proven vaccinations give healthcare providers and community advocates the main tool for prevention of the spread of the disease. It is often taboo to discuss anything related to sexual promiscuity or sexual activity in the United States in the public schools. The biggest myth includes the fear parents and grandparents have is that if HPV is talked about, then the child may become sexually active sooner. This myth needs to be challenged with science and reality including taking on the those vehemently opposed to vaccines, known as “Anti-Vaxers” that obstruct vaccine education. The strategies utilized in public health outreach to the community should be reviewed and uniquely developed for each diverse community to overcome the challenges in the prevention of HPV.

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« Nr. 9 Natrium phosphoricum, Na₂HPO₄ · 12H₂O ». Dans Antlitzanalyse in der Biochemie nach Dr. Schüßler, sous la direction de Thomas Feichtinger et Susana Niedan-Feichtinger. Stuttgart : Georg Thieme Verlag, 2018. http://dx.doi.org/10.1055/b-0037-148018.

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« 9 Viren als Krankheitserreger : 9.5 Humane Papillomaviren (HPV) ». Dans Taschenlehrbuch Medizinische Mikrobiologie, sous la direction de Fritz H. Kayser, Erik C. BÖttger, Rolf M. Zinkernagel, Otto Haller, Johannes Eckert et Peter Deplazes. Stuttgart : Georg Thieme Verlag, 2010. http://dx.doi.org/10.1055/b-0034-85779.

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Yahya, Mondher, Faouzi Hosni et Ahmed Hichem Hamzaoui. « Synthesis and ESR Study of Transition from Ferromagnetism to Superparamagnetism in La0.8Sr0.2MnO3 Nanomanganite ». Dans Smart Nanosystems for Biomedicine, Optoelectronics and Catalysis. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.89951.

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Electron spin resonance (ESR) spectroscopy was used to determine the magnetic state transitions of nanocrystalline La0.8Sr0.2MnO3 at room temperature, as a function of crystallite size. Ferromagnetic nanoparticles having an average crystallite size ranging from 9 to 57 nm are prepared by adopting the autocombustion method with two-step synthesis process. Significant changes of the ESR spectra parameters, such as the line shape, resonance field (Hr), g-factor, linewidth (∆Hpp), and the low-field microwave absorption (LFMA) signal, are indicative of the change in magnetic domain structures from superparamagnetism to single-domain and multi-domain ferromagnetism by increase in the crystallite size. Samples with crystallite sizes less than 24.5 nm are in a superparamagnetic state. Between 24.5 and 32 nm, they are formed by a single-domain ferromagnetic. The multi-domain state arises for higher sizes. In superparamagnetic region, the value of g-factor is practically constant suggesting that the magnetic core size is invariant with decreasing crystallite size. This contradictory observation with the core-shell model was explained by the phenomenon of phase separation that leads to the formation of a new magnetic state that we called multicore superparamagnetic state.

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Actes de conférences sur le sujet "HPS-9"

Ahmad, Fathi, et Alexander V. Mirzamoghadam. « Single vs. Two Stage High Pressure Turbine Design of Modern Aero Engines ». Dans ASME 1999 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/99-gt-001.

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In this paper, the two-stage shrouded HPT engine configuration rated at 22000 lbs thrust is used as the baseline from which a single stage HPT unshrouded design is systematically derived to evaluate the potential weight and cost advantage. The baseline thermodynamic cycle at the rated thrust level was modified in order to optimize the turbine inlet temperature, overall pressure ratio, and core flow with a single stage HPT and deliver competitive performance. The comparative study, although preliminary in depth, has led to the advantages and disadvantages associated with an unshrouded single versus a two-stage shrouded HPT design. The results compare design configuration, secondary air system, weight, safety, life, specific fuel consumption (SFC), and future thrust growth capability. The main advantages of the single stage application are reductions in cost and complexity of design, lower turbine gas temperature, and ease of maintenance. The main disadvantages are in reduced turbine polytropic/isentropic efficiency for HPC pressure ratio greater than 9, increased SFC, higher rim speed, higher HPT exit Mach number, higher bypass ratio to achieve the desired thrust level, and possibly higher weight. A quantitative statement on the reduction of engine cost/weight is premature until a detailed design and the associated cost-benefit is performed. The paper concludes by recommending that the design philosophy of the modern unmixed turbofan engine (single or two-stage HPT) leads to a balance between the selected turbine gas temperature versus the by-pass ratio in order to minimize cost and maximize the thrust-to-weight ratio and the cycle efficiency. In either ease, the expected high reliability and reduced engine cost/weight in the context of future thrust-growth capability need to be demonstrated by proven technology which seem to favor the two-stage HPT configuration.

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Klinger, Holger, Waldemar Lazik et Thomas Wunderlich. « The Engine 3E Core Engine ». Dans ASME Turbo Expo 2008 : Power for Land, Sea, and Air. ASMEDC, 2008. http://dx.doi.org/10.1115/gt2008-50679.

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Engine 3E is the aero engine part of the German Aeronautics Research Program under which Rolls-Royce Deutschland developed key technologies for an all new core engine that incorporates major advances with regard to environmental friendliness, efficiency and economy. The derived E3E core engine will serve as a scalable baseline for the future two-shaft engine family in the medium take-off thrust range between 12 – 40 klb. The core consists of a highly loaded 9-stage HPC, a lean burn combustion chamber with internal fuel staging and a 2-stage shroudless HPT. On the basis of its high specific power, low NOx combustion and low manufacturing cost, it will enable significant improvements in SFC, emissions, unit cost and weight. The related technology demonstrator is currently in the final build and instrumentation phase for testing in an altitude test facility in first quarter 2008.

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Lopez Ruiz, Yeniffer, Julia Marlene Carrera, Gary Nelson Tagarot, Gian Marcio Gey, Daniel Davalos, Ruben Dario Segovia, Danny Rafael Campana et al. « Transforming Legacy Production Operations into Smart Asset Operations in Ecuador ». Dans ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211844-ms.

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Abstract For more than 30 years, most of the fields in Ecuador have reached a high level of maturity that demands several operational and control challenges for multiple processes such as chemical injection, high gas volumes, water cut incremental among many other issues affecting the useful life of downhole equipment installed in the well or devices located on the surface. Furthermore, implementing digital solutions in a field also faces the challenge of allocating faster and agile solutions that add efficiency to production, but at the same time avoid or minimize deferred production for implementation. Fortunately, current digital technologies such as IoT and Edge Computing are combined with cloud applications, controllers and even software to connect and use unimagined solutions for the oil and gas industry. These controls make an easier, faster, and more reliable way guaranteeing the production integrity operations, while reducing carbon footprint and improving work-life balance. Operations case studies in Ecuador will be discussed including not only production engineering analysis but also production operations in the field with a major focus on asset surveillance. Both activities require time-consuming tasks such as field trips and well-by-well analysis, showing the transformation in the way we operate leveraging the use of data, promoting remote operations, and automating the workflows used within the production engineering department. The starting point of this implementation was the well surveillance workflow, carried out at the field level because there was no mature SCADA system. Thus, the Edge was implemented with capabilities based on Internet of Things (IoT) technology to connect the different elements of the production chain. Currently, more than 400 pieces of equipment have been connected to a unified platform, including electro-submersible pumping equipment (ESP), wells with Beam Pumping (BM), injector wells, injection pumps, high-pressure injection equipment, multiphase flow meters and others, which allow us to integrate data, perform real-time analysis and remotely control any equipment that is connected. The impact of this solution is the reduction of production losses by 9%, the reduction of field visits by 23%, the increase in the useful life of the equipment by 32% and the reduction of CO2 emissions by 22.6% in surveillance activities. On the other hand, the integration between the intelligence at the edge and the corresponding instrumentation allowed the creation of two tailored solutions. The first, to automate the annular gas handling process, and the second, to automate and optimize the efficiency of the chemical treatment. The tangible benefits of these solutions are: 12 gas handling equipment operating in the field, resulting in a 12% increase in production compared to wells that do not have the solution, chemical injection accuracy increased up to 99% and corrosion/fouling failures reduced by 50%. Using the benefits of IoT, different applications (more than 14) were implemented such as: flare monitoring and gas volume measurements, virtual flow meter, smart alarms, surveillance of portable multiphase flow meters (Vx Units), pumping equipment of high pressure (HPS) and monitoring and diagnosis of vibrations in rotating equipment

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Comperchio, Dan, et Sameer Behere. « High-Density Computing : Efficient Versus Conventional Design ». Dans ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-52394.

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Data centers are expensive to build and operate. Large data centers cost $9–13/W to build [1] and can consume more than forty times, and up to over two hundred times, the amount of energy and resources consumed by a typical building [2], [3]. Therefore, space and energy considerations need to be accounted for when evaluating competing designs for high-performance computing (HPC) installations. This paper describes the results of an incremental cost and energy savings analysis conducted using data collected from a real-world case study to evaluate the impacts of efficient resource planning and implementing a total cost of ownership (TCO) model in the analysis of IT equipment and systems. The analysis presented demonstrates the advantages of using the latest technologies and IT strategies when planning the growth of new HPC installations at an enterprise level. The data also indicates an efficient design can significantly reduce the space, power, and cooling requirements of the HPC deployment while maintaining the performance and reliability criteria.

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Papapetrou, Georghios Dorou, Chia Pei Chuen, Mohd Nur Adzizie Mahamad, Ros Aliza Md Rabi et Yong Han Seah. « FDP Simulation Studies for Green Fields Cluster Development in Less than 30 Days Utilizing Cloud Technologies ». Dans ADIPEC. SPE, 2022. http://dx.doi.org/10.2118/211415-ms.

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Abstract BD Cluster green fields development located offshore Sabah, Malaysia, consists of three multi-stacked turbidite fields, namely A, B and C, encompassing thick and thin bed sands. Due to the lack of existing infrastructure in close proximity, a wellhead platform (WHP) will be installed on top of Field A. Fields B and C will be developed with a respective 8 and 7km subsea tie back to this WHP. Gas will be exported from the WHP to Facility-1 situated 5km away, whereas oil from a single thin oil rim reservoir in Field A will be exported to Facility-2 50km away. The challenges faced by the Reservoir Engineering (RE) Team was delivering an extensive number of dynamic simulations while adhering to the Field Development Planning (FDP) submission deadline: 1) uncertainty analysis and probabilistic modelling for 9 models, 2) construction of coupled reservoir models 3) screening alternative oil and gas export routes, and 4) optimizing capex phasing by determining the optimum startup sequence of the fields. Delivering the FDP work on time with the limited software licenses and computing infrastructure available on-premise appeared to be a "bridge too far". The limitations were addressed by PETRONAS LiveFDP digital transformation initiative commenced in 2019, through deployment of digital cloud technologies and solutions with scalable High-Performance Computing (HPC) environment. A total of 9 geological models were delivered to REs for dynamic simulation studies. Probabilistic modelling was then employed to obtain the dynamic P10, P50 and P90 models for each field. The Reservoir Coupling facility and Extended Network option were used in the numerical simulator to couple the standalone models in order to honor the overall facility constraints and incorporate the pipeline effects. Utilizing the coupled network model, multiple studies including condensate banking, determining optimum field sequencing and export route scenario were performed. The FDP subsurface development simulation runs were completed within 1 month using HPC cloud solutions and workflows compared to 9 months if using on-premise infrastructure. It provided the necessary tools to allow the team: 1) accurately assess the impact of condensate banking on well productivity, 2) executed over 1200 cases for probabilistic modelling for the 9 models in 24 hours of simulation time, 3) reduced the number of wells derived from a previous study from 14 to 9 yielding a saving of ~US$115 million, 4) ~US$50 million savings as a result of capex phasing by optimizing the field start up sequence, and 5) US$130 million savings by establishing the lowest cost oil and gas export route scenario.

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Suzuki, S. « THE ABSORPTION, EXCRETION AND TRANSPLACENTAL TRANSPORT OF VITAMIN K IN THE PERINATAL PERIOD ». Dans XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644262.

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It is a well-known fact that hemorrhages are observed in wholly breastfed infants beyond the neonatal period. In order to clarify vitamin K (VK)-deficiency, it is necessary to follow-up the absorption and excretion of VK2.1. To 128 cases of newborns. i) The activity of VK-dependent factors(II, VII, X) were determined by Hepaplastin test(HPT), ii) Using Latex-test, PIVKA-II was tested. We found values of HPT (Y) and PIVKA-II (X) to be inversely proportional in the relation. Y=6l.9 - 6.7 X (r= -0.3). 2. These 15 cases of hypoprothrombinemia, VK2 6mg, VK2 2mgwere given, and plasma VK2-concentration was measured by gas chromatography. After 3 hours VK2 6mgconcentration was 1030ng/ml; VK2 2mg, was 224ng/ml. This clearly shows a dose-response relation. 3. VK2 transplacental transport was also proved by using umbilical venous blood after Cesarean section. (Before Cesarean section, VK2 60mgwas given. ) In umbilical venous blood, relatively high doses of VK2 (50 - 120ng/ml) were demonstrated. Additionally, the y-carboxylglutamic acid-concentration in the urine of newborn, who received VK2-syrup was higherthan those who did not receive it.

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Paz, José Matheus Lima Paiva da, et Juliana Prado Gonçales. « CONTRIBUIÇÃO DO SISTEMA CRISPR CAS-9 NOS AVANÇOS DA ONCOLOGIA ». Dans XXVII Semana de Biomedicina Inovação e Ciência. Editora IME, 2021. http://dx.doi.org/10.51161/9786588884119/4.

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Introdução: O câncer é uma das doenças que apresentam maior morbimortalidade, responsável por 9.6 milhões de mortes e 18 milhões de novos casos em 2018, estando entre as quatro principais causas de mortes prematuras (antes dos 70 anos de idade), um em cada cinco mortes no mundo é relacionada a doença. A incidência e a mortalidade têm aumentado e seus principais motivos são o envelhecimento populacional e prevalência dos fatores de risco (predisposição genética, consumo de álcool, tabaco, dieta, sedentarismo e como também o papiloma vírus humano (HPV).(1, 2) De maneira geral, os tumores são resultados de mutações em certos pontos do genoma, principalmente naqueles que estão diretamente relacionados ao mecanismo de reparo do DNA e apoptose celular que ocasiona multiplicação anormal de algum tipo de célula, podendo ocorrer migração para outras partes do corpo, se desenvolvendo fora do local de origem (metástase).(3) Objetivos: descrever a contribuição do sistema Crispr Cas-9 nos avanços da oncologia. Métodos: Trata-se de um estudo de literatura que consultou a base de dados Us National Library of Medicine National Institutes of Health (Pubmed) de 2016 até 2021. Resultados: A pesquisa realizada por Williams e Largaespada fez uso do sistema CRISPR CAS-9 (Clustered Regularly Interspaced Short Palindromic Repeats) para a ampliação dos tratamentos da neurofibromatose causada por mutações no gene supressor de tumor NF1 (codifica a neurofibromina).(4) Já Xiao, Chen e Cui lançaram mão da CRISPR CAS-9 para a depleção do mRNA-21 em carcinoma nasofaringe tendo êxito em suprimir o crescimento celular, bem como sua proliferação nas células CNE2. Ao comparar com grupo controle com o grupo experimental (sgRNA-mir-21) notou-se que expressões de Bcl-2 e Bcl-L diminuíram e a Caspase-3 foi ativada e esses resultados implicaram que o knockdown direcionado do miR-21 foram capazes de induzir apoptose nas células alvos.(5) Conclusões: Levando-se em consideração o que foi abordado, fica evidente que apesar do câncer ser uma doença multifatorial, o novo mosaico que a biotecnologia emergente CRSPR CAS-9 proporciona é um grande diferencial já que pode levar a conhecer as doenças por pontos que antes não eram possíveis e como também transformar o modo de combate-las.

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Stephens, Julia E., et Sameer Kulkarni. « Calibration of a V-Cone for Low Mass Flows for Small Core Compressor Research ». Dans ASME Turbo Expo 2020 : Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-16104.

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Abstract Advancements in core compressor technologies are necessary for next generation, high Overall Pressure Ratio (OPR) turbofan engines. High pressure compressors (HPCs) for future engines are being designed with exit corrected mass flow rates less than 2.25 kg/s (5 lbm/s). In order to accurately measure the performance of these advanced designs, high accuracy measurements are needed in test facilities. The W7 High Speed Multistage Axial Compressor Facility at NASA Glenn Research Center has been used to acquire data for advanced compressor designs. This facility utilizes an advanced differential pressure flow meter called a V-Cone. The facility has historically tested components with physical mass flow rates in the range of 27 to 45 kg/s (60 to 100 lbm/s). As such, when the V-Cone was calibrated prior to installation, the calibrations focused on higher mass flow rates, and uncertainties in that regime range from 0.5% to 0.85%. However, for low mass flow rates under 9 kg/s (20 lbm/s), expected in tests of advanced high OPR HPCs rear stages, the uncertainties of the V-Cone exceed 2.5%. To address this, using a method similar to that utilized by the National Institute of Standards and Technology, an array of Critical Flow Venturi Nozzles (CFVs) was installed in the W7 test section and used to calibrate the V-Cone in 0.5 kg/s (1 lbm/s) increments up to 10.5 kg/s (23 lbm/s). This effort details the measurements and uncertainties associated with this calibration which resulted in a final uncertainty of the V-Cone measurements under 1%.

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Lück, Sebastian, Stefan Kuntzagk, Guido Doebbener, Andreas Kellersmann, Christoph Bode et Jens Friedrichs. « Accuracy Assessment of Steady and Unsteady Multistage High Pressure Compressor Simulations ». Dans ASME Turbo Expo 2019 : Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/gt2019-91310.

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Abstract In this paper a comparison of the performance parameters and flow characteristics of a mature commercial high bypass engine’s 9-stages high pressure compressor (HPC) with steady-state mixing-plane (RANS) and unsteady RANS (URANS) CFD is carried out. The investigation is based on a numerical model of the CFM56-5C engine’s HPC which is installed on the Airbus A340-300 aircraft. The compressor under investigation features the so called 3D blading which is the first of two performance improvement packages available. An experimental engine of this type equipped with extensive additional instrumentation is in use by Lufthansa Technik to deliver detailed experimental data of the gas path. Experimental results have been discussed in previous works of the authors. In order to provide long-term forecasts of an engine’s state the aforementioned CFD model has been included into a multilevel engine model. To be able to evaluate the significance and applicability of the CFD results into such model, it is of great interest to which extent and level of detail it can deliver accurate performance predictions. From the comparison of both steady-state and unsteady simulation results it is found that overall compressor performance only differs negligibly while stage performance can differ significantly. It is depicted that among the stator vanes of the front stages local supersonic flow and flow separation can occur. These are not captured by the steady-state simulation to the same degree a time resolved simulation does. In rear stages differences fade and unsteady methods tend to predict better stage performance which may be due to favourable effects of rotor-stator interaction.

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Guiotti, Isabela Furtado, Maria Eduarda Cançado Schuttenberg, Lucas Pedrosa Lange, Maria de Fátima Dias de Sousa Brito, Enzo Brito Teixeira et Ana Tercia Beltrame Carvalho. « Neoplasia intraepitelial de alto grau vulvovaginal comfoco de invasão em fúrcula ». Dans 45º Congresso da SGORJ XXIV Trocando Ideias. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/jbg-0368-1416-20211311059.

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Introdução: Cerca de 1 em 100 mil mulheres é diagnosticada com câncer vaginal invasivo ou in situ, sendo mais frequente o do tipo escamoso e na idade média de 60 anos. Nos EUA, a incidência de neoplasia intraepitelial vulvar (NIV) 3 ou neoplasial intraepitelial de alto grau (HSIL) foi de 2,86 por 100 mil mulheres no ano 2000. Em ambas as lesões de alto grau, a associação com a infecção por papilomavírus humano (HPV) é frequente. Relato de caso: C.R.J., 53 anos, atendida em 2017 por verrugas genitais não responsivas ao ácido tricloroacético. Negava infecção sexualmente transmissível, comorbidades e tabagismo. Apresentava cinco verrugas vulvares e colposcopia: zona de transformação normal. Prescreveu-se imiquimod por três semanas, sem melhora das lesões. A paciente foi submetida à exérese das lesões persistentes, com resultado de condiloma acuminado. Retornou em 2019 com mácula plana em fúrcula vaginal de bordas elevadas, sem acetorreatividade, cuja biópsia revelou neoplasia intraepitelial vaginal (NIVA) III, com focos de microinvasão. Realizou a excisão cirúrgica, e o anatomopatológico evidenciou NIV III com margem cirúrgica comprometida. Em 2020 foi submetida à ampliação da margem, com resultado: NIV III ulcerada associada a NIV II, infecção por HPV. O tratamento foi complementado com imiquimod três vezes por semana por quatro semanas. Ao retorno, a paciente demonstrou ausência de áreas hipercrômicas ou acetorreativas. Conclusão: O epitélio anogenital é derivado da cloaca embrionária e inclui colo do útero, vagina, vulva, ânus e 3 cm inferiores da mucosa retal até a linha dentada. Uma vez que toda a região compartilha a mesma origem embriológica, é susceptível a agentes exógenos semelhantes, como infecção por HPV. Neoplasias intraepiteliais nessa área são frequentemente multifocais (focos dentro do mesmo órgão) e multicêntricos (focos envolvendo mais de um órgão). Paciente com infecção prévia por HPV é considerada de risco para o surgimento de HSIL, mesmo se as manifestações prévias forem de baixo grau, que não são consideradas precursoras dos cânceres anogenitais. A maioria dos HSIL vulvares é multifocal e está localizada na parte não pilosa da vulva. As lesões são frequentemente elevadas ou verrucosas e brancas. Lesões maculares ocorrem principalmente em superfícies mucosas adjacentes. Não há aparência clínica patognomônica, e mais de um desses padrões podem ser vistos no mesmo paciente. O risco cumulativo de 10 anos de desenvolver carcinoma escamoso vulvar com HSIL é de 9,7%. A NIVA de alto grau tem história natural menos conhecida, e Aho et al., em acompanhamento por 15 anos de 23 pacientes, encontraram progressão para invasão em 9% em quatro anos. Pobre em sintomas, a avaliação colposcópica e a biópsia dirigida são o padrão ouro para o diagnóstico. No seguimento de pacientes com HSIL anogenital, é essencial o exame pélvico cuidadoso, contemplando colo, vagina, vulva e região perianal. A cada avaliação, múltiplas biópsias podem ser necessárias, sempre que forem identificadas novas lesões à avaliação colposcópica.

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Rapports d'organisations sur le sujet "HPS-9"

Zachary, S. H., et William R. Stapper. Evaluation of Navy 9 cst Oil in Bell Helicopter M412 HP Gearboxes. Fort Belvoir, VA : Defense Technical Information Center, août 1998. http://dx.doi.org/10.21236/ada351965.

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