Articles de revues : « HPA axi »

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RAO, D. V. BHASKAR. « Tropical cyclone simulation with Emanuel’s convection scheme ». MAUSAM 48, n^o 2 (15 décembre 2021) : 113–22. http://dx.doi.org/10.54302/mausam.v48i2.3953.

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ABSTRACT. A new convection parameterization scheme proposed by Emanuel (1991) is used to simulate the evolution of tropical cyclone. The numerical model used for this study is a 19 level axi-symmetric primitive equation, hydrostatic model in a z co-ordinate system. The vertical domain ranges from 0 to 18 km and the horizontal domain ranges upto 3114 km with a resolution of 20 km. in the central 400 km radius and with increasing radial distance thereafter. The evolution of an initially balanced vortex with an initial strength of 9 m/sec is studied. It is shown that Emanuel's convection scheme is successful in simulating the development of the initial vortex into a mature, intense cyclonic storm. At the mature stage, a minimum surface pressure of 930 hPa is attained with the associated low level maximum tangential wind speed of 70 m/sec. The simulated circulation features at the mature stage show the formation of an intense cyclone. Two different sensitivity experiments were performed. A set of experiments with the variation of sea surface temperature (SST) from 300.5° to 302° K in steps of 0.5° K have shown that the intensity of model cyclone increases with the increase of SST. Another set of experiments with variation of latitude has shown that the cyclonic storm is more intense at lower latitudes.

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Kim, Eun Hwa, et Na Hyun Kim. « Comparison of Stress Level and HPA axis Activity of Internet Game Addiction vs. Non-addiction in Adolescents ». Journal of Korean Biological Nursing Science 15, n^o 4 (30 novembre 2013) : 173–83. http://dx.doi.org/10.7586/jkbns.2013.15.4.173.

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Chen, Feilong, Yao Xu, Siqi Sun, Xiaowei Shi, Aimin Liu et Shaoxing Chen. « Halomicroarcula amylolytica sp. nov., a novel halophilic archaeon isolated from a salt mine ». International Journal of Systematic and Evolutionary Microbiology 70, n^o 9 (1 septembre 2020) : 4978–85. http://dx.doi.org/10.1099/ijsem.0.004368.

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A halophilic archaeon named strain LR21T was isolated from a salt mine in Yunnan Province, PR China. Cells were spherical, Gram-stain-negative and motile. Strain LR21T grew at 20–50 °C (optimum, 42 °C), with 8–30 % (w/v) NaCl (optimum, 23 %) and at pH 5.5–9.5 (optimum, pH 7.5–8.5). Mg2+ was not required for growth. The major polar lipid profile comprised phosphatidylglycerol, phosphatidylglycerol phosphate methyl ester and phosphatidylglycerol sulfate. Strain LR21T had two dissimilar 16S rRNA genes (rrnA and rrnB) and they were closely related to Halomicroarcula limicola YGHS32T, Hma. pellucida BNERC31T and Hma. salina YGHS18T with sequence similarities of 95.3–99.0, 93.0–96.2 and 93.2–95.9 %, respectively, and much lower values to other members. The rpoB′ gene sequence similarities between strain LR21T and Hma. limicola YGHS32T, Hma. pellucida BNERC31T and Hma. salina YGHS18T were 95.2, 91.2 and 91.2 % respectively. The values of average nucleotide identity (ANI) and average amino-acid identity (AAI) between strain LR21T and Hma. limicola YGHS32T, were 89.0 and 90.1 %, respectively. DNA relatedness between strains LR21T and Hma. limicola YGHS32T determined by in silico DNA–DNA hybridization was 36.8 %. Values of ANI and AAI between strain LR21T and other members in the genus Halomicroarcula were far below 95 % and the DNA–DNA relatedness values between strain LR21T and its close relatives were much lower than 70 %, which is far below the boundary for delineation of a new species prokaryote. The DNA G+C content of strain LR21T was 62.0 mol% (genome). The results suggested that strain LR21T represents a novel species of the genus Halomicroarcula , for which the name Halomicroarcula amylolytica sp. nov. is proposed. The type strain is LR21T (=CGMCC 1.13611T=NBRC 113588T).

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Seo, Hyung-Seok, et Tae-Wook Kim. « Effects of cardiopulmonary fitness level on HPA axis hormone secretion and lipolysis during passive heating ». Korean Journal of Sports Science 26, n^o 3 (30 juin 2017) : 999–1008. http://dx.doi.org/10.35159/kjss.2017.06.26.3.999.

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Silliman, Christopher C., Marguerite R. Kelher, Samina Y. Khan et Samuel O. Sowemimo-Coker. « Experimental Antibody Filtration Inhibits Antibody-Mediated Neutrophil Priming and TRALI in An In Vivo model ». Blood 118, n^o 21 (18 novembre 2011) : 41. http://dx.doi.org/10.1182/blood.v118.21.41.41.

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Abstract Abstract 41 Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion-related death with a majority of the reported cases secondary to the infusion of antibodies (Abs) contained within the plasma/blood component. An experimental filter that removes IgG was developed. We hypothesize that filtration of plasma with antibodies to leukocyte antigens will decrease both antibody-mediated priming of PMNs and antibody-mediated TRALI in a two-event in vivo model. Methods: Human plasma was drawn from healthy volunteers and IgG concentrations were measured before and after filtration. Plasma was obtained from two multiparous female donors: one with antibodies to HLA-A2 and to DR7 and the other with antibodies against HNA-3a. These plasma samples were filtered (F-Plas) or left as an unmodified control (Plas) and the anti-leukocyte antibodies were measured in a blinded fashion in referral labs using flow cytometry and Luminex™ beads or standard granulocyte antibody detection assays. These plasma samples were then used to prime the fMLP-activated respiratory burst, measured as the SOD-inhibitable reduction of cytochrome c (nmol O2−/min), of PMNs from HNA-3a+ donors or donors homozygous donors for HLA-A2, respectively. For the two-event in vivo modeling rats were incubated with 2 μg/ml endotoxin (LPS, S. enteritides) or saline (NS) for 2 hours (first event) and then were transfused with heat-treated human plasma that contained 25 μg/ml of an antibody against the MHC class I antigen OX27 that was either filtered (or left unmodified) prior to infusion (second event) followed by Evans Blue dye (EBD). ALI was measured as %EBD leak from the plasma into the bronchoalveolar lavage fluid. Statistical differences were measured via paired (PMN priming) or independent (in vivo TRALI) ANOVA, and data are reported as the mean ± the standard error of the mean. *=p<.05 vs. all groups (Table). Results: Plasma filtration removed 98±2.1% of IgG from normal plasma and both the antibodies to HNA-3a and HLA-A2 such that they were no longer detected (HLA-A2: 94 Luminex™ units (LU) pre-filtration and 0 LU units post-filtration and DR7: 30 LU pre-filtration and 0 LU post-filtration). In addition, filtration also inhibited the priming activity of the plasma containing antibodies to HNA-3a and HLA-A2 on HNA-3A+ PMNs and HLA-A2+ PMNs, respectively. Moreover, the plasma spiked with antibodies to OX27 caused ALI in LPS-treated rats, but not NS treated animals, which was inhibited by filtration. We conclude that this experimental filter removes IgG and detectable amounts of specific antibodies to HLA and HNA ligands as well as obviating the priming activity of these antibodies in PMNs which express the cognate antigens. Filtration of plasma spiked with specific antibodies to MHC ligands also abrogated the antibody-induced TRALI in a two-event, in vivo model. Such a filtration step could mitigate antibody-mediated TRALI.Abs/Tx'sfMLP (O2− nmol/min)Plas+ fMLPF-plas+ fMLPNS/plas (% EBD)NS/F-PlasLPS/PlasLPS/F-PlasHNA-3a0.7 ± .31.1 ± .2*0.6 ± .2HLA-A21.6 ± .63.4 ± .4*1.5 ± .4OX270.09 ± .020.13 ± .030.4 ± .14*0.13 ± .03 Disclosures: Silliman: Pall Corporation: Honoraria. Sowemimo-Coker:Pall Medical Corporation: Employment.

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Rychlik, A., M. Nowicki, A. Kolodziejska-Sawerska et M. Szweda. « The effect of orally administered Budesonide on the hypothalamic-pituitary-adrenal axis in dogs with inflammatory bowel disease ». Veterinární Medicína 62, No. 5 (9 mai 2017) : 261–68. http://dx.doi.org/10.17221/130/2015-vetmed.

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The aim of this study was to evaluate the effect of Budesonide on the hypothalamic-pituitary-adrenal (HPA) axis in dogs with inflammatory bowel disease. The effect of orally administered Budesonide (Entocort) on the HPA axis was analysed in 21 dogs with inflammatory bowel disease. Biochemical analyses were carried out to evaluate the activity levels of alanine aminotransferase, asparagine aminotransferase, alkaline phosphatase, cortisol and endogenous adrenocorticotropic hormone. Urine samples were collected from each patient before the study and after 30 days of the experiment to determine the composition and the physical and chemical properties of urine sediments. Considerably lower serum concentrations of cortisol and endogenous adrenocorticotropic hormone were observed after 30 days of treatment. A significant increase in alkaline phosphatase levels was noted on Day 30. In the studied dogs, the drop in HPA axis activity was correlated with side effects associated with the administered glucocorticosteroid (polyuria, polydipsia). In conclusion, we have shown that oral administration of Budesonide to dogs diagnosed with inflammatory bowel disease significantly suppressed the activity of the HPA axis.

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Thoß, Hendrik. « Jonathan Eig : Ali. Ein Leben ». Das Historisch-Politische Buch 67, n^o 2 (1 juin 2019) : 188–89. http://dx.doi.org/10.3790/hpb.67.2.188.

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Wu, Huang-Pin, Li-Pang Chuang, Pi-Hua Liu, Chien-Ming Chu, Chung-Chieh Yu, Shih-Wei Lin, Kuo-Chin Kao, Li-Fu Li et Duen-Yau Chuang. « Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury ». Medicina 58, n^o 9 (1 septembre 2022) : 1198. http://dx.doi.org/10.3390/medicina58091198.

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Background and objectives: Acute kidney injury (AKI) is common in critically ill patients, especially those with sepsis. Persistently low human leukocyte antigen (HLA)-DR expression in monocytes reflects the decreased function of antigen-presenting cells, contributing to poor outcomes in sepsis. This study aimed to establish an association between AKI and HLA-DR expression in monocytes of patients with sepsis. Materials and Methods: We detected HLA-DR expression in monocytes and measured plasma levels of S100A12, high-mobility group box 1 (HMGB1), advanced glycation end products (AGE), and soluble receptor for AGE (sRAGE) from septic patients and healthy controls. Results: HLA-DR expression in monocytes was decreased in patients with AKI than in those without AKI (29.8 ± 5.0% vs. 53.1 ± 5.8%, p = 0.005). Compared with AKI patients, the mean monocyte HLA-DR expression in patients with end-stage renal disease was increased without statistical significance. There were no differences in the AGE/sRAGE ratio and plasma levels of S100A12, HMGB1, AGE, and sRAGE between patients with and without AKI. Conclusions: Compared with septic patients without AKI, patients with AKI had significantly lower HLA-DR expression in monocytes. The role of hemodialysis in monocyte HLA-DR expression needs further studies to explore.

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Erum Shireen, Erum Shireen, Wafa Binte Ali Wafa Binte Ali, Maria Masroor Maria Masroor, Saeeda Bano Saeeda Bano, Samina Iqbal Samina Iqbal et Muhammad Mansoor Hai and Darakhshan J. Haleem Muhammad Mansoor Hai and Darakhshan J Haleem. « Acute Stress Induced Behavioral Deficits In Rats : Relationship With Oxidative Stress, Leptin And HPA Axis ». Journal of the chemical society of pakistan 41, n^o 5 (2019) : 859. http://dx.doi.org/10.52568/000804/jcsp/41.05.2019.

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Acute exposure to stress is connected to many disorders that promote the toxicity of oxygen radical generators leading to increase in the levels of enzymes and also the activation of the HPA axis. The present study uses a preclinical approach to elucidate some prospective stress-induced behavioral and biochemical effects. The aim of current study was to investigate the relationship between stress and behavioral changes after exposing animals to 2h immobilization stress. We also evaluated the concentration of corticosterone, glucose and endogenous leptin levels in unstressed and stressed animals to explore the possible role of HPA axis in the modulation of stressed induced behavioral deficits. Rats were divided into stressed and unstressed groups. Behavioral activities were monitored in open field activity and light dark transition box after the termination of 2h immobilization period. Animals were then decapitated and plasma samples were collected for catalase, SOD, corticosterone, and glucose estimation. Results showed that exposure to acute stress produced a significant decrease in the activity of rats in the novel environment (open field) and light dark transition box. On the other hand, concomitant elevated level of peripheral markers of oxidative stress such as oxidative enzymes, corticosterone and endogenous leptin were also observed. Therefore, current study seems to suggest an important role of compounds having antioxidant properties for the treatment of stress and related disorders.

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Elhachimi, Fouad E. « HPAT Axis Dysfunction and Type II Diabetes Review ». Journal of Quality in Health Care & ; Economics 5, n^o 6 (2022) : 1–4. http://dx.doi.org/10.23880/jqhe-16000308.

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According to the CDC, 1 in 10 or more than 34 million Americans have diabetes, and approximately 90 to 95% have type II diabetes (T2D). Between 1990 and 2010, the number of new diagnoses doubled yearly, and the number of patients living with diabetes tripled. This review establishes a direct association between the hypothalamic-pituitary-adrenal and thyroid (HPAT) axis dysregulation and T2D. In this review, we will focus on the compelling evidence that shows the progressive dysregulation of the HPAT axis and the increased values of circulating cortisol which is involved in the formation of visceral obesity through thyroid hormones, which play a crucial role in regulating energy and metabolism by controlling insulin production and glucose homeostasis, and how the HPAT axis plays a significant role in preventing or causing the development of T2D.

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Radišauskas, Ričardas, Vidmantas Vaičiulis, Rūta Ustinavičienė et Gailutė Bernotienė. « The Effect of Atmospheric Temperature and Pressure on the Occurrence of Acute Myocardial Infarction in Kaunas ». Medicina 49, n^o 10 (4 novembre 2013) : 70. http://dx.doi.org/10.3390/medicina49100070.

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Objective. The aim of the study was to evaluate the impact of meteorological variables (atmospheric temperature and pressure) on the daily occurrence of acute myocardial infarction (AMI). Material and Methods. The study used the daily values of atmospheric temperature and pressure in 2000–2007. The meteorological data were obtained from the Lithuanian Hydrometeorological Service for Kaunas. The relative risks of event occurrence were computed for 5°C atmospheric temperature and for 10-hPa atmospheric pressure variations by means of the Poisson regression model. Results. The occurrence of AMI and atmospheric temperature showed an inverse linear relationship, while the occurrence of AMI and atmospheric pressure, a positive linear relationship. Among the youngest subjects (25–44 years old), no relationships were detected. Contrary, among the subjects aged 45–64 years and those aged 65 years and older, the occurrence of AMI significantly decreased with higher temperature (P=0.001 and P=0.002, respectively). A decrease in atmospheric temperature by 10ºC reduced the risk of AMI by 8.7% in the age groups of 45–64 and 65 years and older and by 19% in the age group of 25 years and older. Among the first AMI cases, the risk increased by 7.5% in the age group of 45–64-year olds and by 6.4% in the age group of 25–64-year olds. The relationship between atmospheric temperature and pressure, and AMI occurrence was found to be linear but inverse. An increase in atmospheric pressure by 10 hPa resulted in an increase in risk by 4% among the subjects aged 65 years and more and by 3% among the subjects aged 25 years and more. Conclusions. Atmospheric temperature and pressure variations had the greatest effect on middle- aged and aging subjects (starting from 45 years). At younger age, the effect of such factors on the AMI risk was considerably lower.

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Biteznik, Alenka, Barbara Faganel Kotnik et Petja Fister. « Hemolitična anemija in trombocitopenija ob fetomaternalnem neskladju krvnih skupin ABO : prikaz primera ». Slovenian Medical Journal 88, n^o 5-6 (31 mai 2019) : 282–90. http://dx.doi.org/10.6016/zdravvestn.2843.

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Odkar izvajamo zaščito RhD-negativnih nosečnic z anti-D protitelesi, je najpogostejši vzrok za hemolitično bolezen novorojenčka neskladje ABO krvnih skupin matere in ploda oz. novorojenčka. Hemolizo povzročajo protitelesa, ki so posledica izoimunizacije matere, in prehajajo preko posteljice v plod, kjer uničujejo plodove in novorojenčkove eritrocite. Bolezen se kaže s hemolitično anemijo, težko zgodnjo zlatenico in splenomegalijo. Ker so antigeni ABO prisotni tudi na trombocitih in drugih tkivih, lahko protitelesa anti-A ali anti-B v redkih primerih povzročijo tudi trombocitopenijo, saj se protitelesa odzivajo z istimi antigeni, prisotnimi tudi na trombocitih. V članku predstavljamo donošeno novorojenko s krvno skupino (KS) A, RhD pozitivno, po Kellu negativno, ki smo jo obravnavali zaradi hemolitične anemije in trombocitopenije. Materi so med nosečnostjo določili KS O, da je RhD pozitivna in po Kellu negativna. Ob sprejemu je bila deklica subikterična. Laboratorijski izvidi v starosti 100 ur so bili: hemoglobin 152 g/L, trombociti 44 × 109/L, celokupni bilirubin 254 μmol/L in direktni bilirubin 10,6 μmol/L. Direktni Coombsov test (DCT) pri deklici je bil pozitiven, imela je prisotna protitelesa anti-A IgG. Ob fototerapiji so vrednosti bilirubina ustrezno upadle. Zaradi trombocitopenije pri novorojenki smo analizirali materin hemogram, ki je pokazal normalno koncentracijo trombocitov v periferni krvi ter nato opravili genotipizacijo HPA pri materi in novorojenki, ki ni pokazala neskladja. Opravili smo tudi direktni test trombocitnih protiteles, ki je bil negativen. Za trombocite specifičnih protiteles (HPA in HLA) nismo uspeli potrditi. Število trombocitov se je spontano zvišalo. Ob zadnjem pregledu je v hemogramu izstopala nevtropenija, ki je spontano izzvenela do starosti 4 mesecev in pol.

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Park, Yunjung, et Dugki Min. « HLA-DDS API Transformation for DDS Communication Based HLA Simulation ». Advanced Science Letters 21, n^o 3 (1 mars 2015) : 244–52. http://dx.doi.org/10.1166/asl.2015.5836.

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Bullich, Sébastien, Sarah Delcourte, Nasser Haddjeri et Bruno P. Guiard. « Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype ». International Journal of Molecular Sciences 22, n^o 2 (19 janvier 2021) : 937. http://dx.doi.org/10.3390/ijms22020937.

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The forced swim stress test (FST) is widely used for screening pharmacological or non-pharmacological strategies with potential antidepressant activities. Recent data have suggested that repeated FST for five consecutive days (i.e., 5d-RFSS) could be used to generate a robust depressive-like phenotype in mice. However, the face, construct, and predictive validities of 5d-RFSS have been recently challenged. This study took advantage of recent findings showing that mice vulnerability to anxiety is enhanced when animals are stressed during the dark phase, to provide new insight into the relevance of this model. Our results showed a progressive increase in time of immobility in 5d-RFSS mice relative to control non-stressed animals (sham). Three weeks later, we noticed that 5d-RFSS mice injected with the vehicle compound (Veh) still exhibited a high level of immobility in the FST whereas this behavior was reversed by the antidepressant drug amitriptyline (AMI). However, 5d-RFSS/Veh and 5d-RFSS mice/AMI mice showed normal performances in the open field, the novelty suppressed feeding and the tail suspension tests. Despite this lack of generalized behavioral deficits, an impairment of different parameters characterizing the hypothalamic-pituitary-adrenal (HPA) axis reactivity was evidenced in 5d-RFSS mice/Veh but not in 5d-RFSS mice/AMI. Despite anomalies in the HPA axis, the activity of the central serotonergic system remained unaffected in 5d-RFSS mice relative to controls. From our results, it is suggested that learned immobility does not replicate the broad spectrum of depressive symptoms observed in other chronic models of depression such as the unpredictable chronic mild stress (UCMS) model, the chronic social defeat stress (CSDS) model or chronic corticosterone (CORT) exposure but its influence on the HPA axis is remarkable. Further experiments are warranted to makes this model suitable for modelling depression and therefore refine its translational applicability.

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Vekstein, Andrew M., Babtunde A. Yerokun, Oliver K. Jawitz, Julie W. Doberne, Jatin Anand, Jorn Karhausen, David N. Ranney et al. « Does deeper hypothermia reduce the risk of acute kidney injury after circulatory arrest for aortic arch surgery ? » European Journal of Cardio-Thoracic Surgery 60, n^o 2 (24 février 2021) : 314–21. http://dx.doi.org/10.1093/ejcts/ezab044.

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Abstract OBJECTIVES The impact of hypothermic circulatory arrest (HCA) temperature on postoperative acute kidney injury (AKI) has not been evaluated. This study examined the association between circulatory arrest temperatures and AKI in patients undergoing proximal aortic surgery with HCA. METHODS A total of 759 consecutive patients who underwent proximal aortic surgery (ascending ± valve ± root) including arch replacement requiring HCA between July 2005 and December 2016 were identified from a prospectively maintained institutional aortic surgery database. The primary outcome was AKI as defined by Risk, Injury, Failure, Loss, End Stage Renal Disease (ESRD) criteria. The association between minimum nasopharyngeal (NP) and bladder temperatures during HCA and postoperative AKI was assessed, adjusting for patient-level factors using multivariable logistic regression. RESULTS A total of 85% (n = 645) of patients underwent deep hypothermia (14.1–20.0°C), 11% (n = 83) low-moderate hypothermia (20.1–24.0°C) and 4% (n = 31) high-moderate hypothermia (24.1–28.0°C) as classified by NP temperature. When analysed by bladder temperature, 59% (n = 447) underwent deep hypothermia, 22% (n = 170) low-moderate, 16% (n = 118) high-moderate and 3% mild (n = 24) (28.1–34.0°C) hypothermia. The median systemic circulatory arrest time was 17 min. The incidence of AKI did not differ between hypothermia groups, whether analysed using minimum NP or bladder temperature. In the multivariable analysis, the association between degree of hypothermia and AKI remained non-significant whether analysed as a categorical variable (hypothermia group) or as a continuous variable (minimum NP or bladder temperature) (all P > 0.05). CONCLUSIONS In patients undergoing proximal aortic surgery including arch replacement requiring HCA, degree of systemic hypothermia was not associated with the risk of AKI. These data suggest that moderate hypothermia does not confer increased risk of AKI for patients requiring circulatory arrest, although additional prospective data are needed.

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Qian, Xuan, Yongqiang Yao, Hongshuai Wang, Lei Zou et Yao Li. « Statistics and analysis of high-altitude wind above the western Tibetan Plateau ». Monthly Notices of the Royal Astronomical Society 498, n^o 4 (6 octobre 2020) : 5786–97. http://dx.doi.org/10.1093/mnras/staa2662.

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ABSTRACT This article aims at studying the characteristics of high-altitude wind at the Ali Observatory on the western Tibetan Plateau, as the high-altitude wind has been put forward as a critical parameter for site evaluation, especially for adaptive optics. We have run a meso-scale numerical weather research and forecasting (WRF) model in three nested domains with different horizontal resolutions, centred at the Ali Observatory; the model results with the highest horizontal resolution of 1 km and temporal resolution of 0.5 h are presented, and also statistical analyseis of vertical wind profiles and 200 hPa wind speed are performed. Moreover, comparisons of wind speeds obtained from model and radiosoundings are presented; as the vertical resolution has been proved to be key to the estimation of optical turbulence with meso-scale models, the vertical resolutions are both set to 50 m for wind profiles, which reveals a high level of agreement and provides a useful tool for site assessment. The results prove the good character of the high-altitude wind over the Ali region, especially in summer half year, with a yearly median 200 hPa wind speed of 33.6 m s−1 in 2016, and also provide proof of the potential advantage of the Ali Observatory for adaptive optics. Furthermore, we certify that meso-scale models can offer dependable estimation of high-altitude wind over the Tibetan Plateau; the wind simulations provided by the WRF model will be of great benefit for adaptive optics, which also provides the vertical distributions of CN2 and τ0 above astronomical observatories.

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Hackmon, Rinat, Lakmini Pinnaduwage, Jianhong Zhang, Stephen J. Lye, Daniel E. Geraghty et Caroline E. Dunk. « Definitive class I human leukocyte antigen expression in gestational placentation : HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturition ». American Journal of Reproductive Immunology 77, n^o 6 (10 février 2017) : e12643. http://dx.doi.org/10.1111/aji.12643.

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Lee, Kwan Yong, Byung-Hee Hwang, Chan Jun Kim, Young Kyoung Sa, Young Choi, Jin-Jin Kim, Eun-Ho Choo et al. « Prognostic Impact of the HFA-PEFF Score in Patients with Acute Myocardial Infarction and an Intermediate to High HFA-PEFF Score ». Journal of Clinical Medicine 11, n^o 15 (5 août 2022) : 4589. http://dx.doi.org/10.3390/jcm11154589.

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This study aimed to investigate the efficacy of the HFA-PEFF score in predicting the long-term risks in patients with acute myocardial infarction (AMI) and an HFA-PEFF score ≥ 2. The subjects were divided according to their HFA-PEFF score into intermediate (2–3 points) and high (4–6 points) score groups. The primary outcome was all-cause mortality. Of 1018 patients with AMI and an HFA-PEFF score of ≥2, 712 (69.9%) and 306 (30.1%) were classified into the intermediate and high score groups, respectively. Over a median follow-up of 4.8 (3.2, 6.5) years, 114 (16.0%) and 87 (28.4%) patients died in each group. Multivariate Cox regression identified a high HFA-PEFF score as an independent predictor of all-cause mortality [hazard ratio (HR): 1.53, 95% CI: 1.15–2.04, p = 0.004]. The predictive accuracies for the discrimination and reclassification were significantly improved (C-index 0.750 [95% CI 0.712–0.789]; p = 0.049 and NRI 0.330 [95% CI 0.180–0.479]; p < 0.001) upon the addition of a high HFA-PEFF score to clinical risk factors. The model was better at predicting combined events of all-cause mortality and heart failure readmission (C-index 0.754 [95% CI 0.716–0.791]; p = 0.033, NRI 0.372 [95% CI 0.227–0.518]; p < 0.001). In the AMI cohort, the HFA-PEFF score can effectively predict the prognosis of patients with an HFA-PEFF score of ≥2.

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McCue, Michael J., et Jan P. Clement. « Characteristics of the Divested HCA and AMI Hospitals ». Medical Care 30, n^o 4 (avril 1992) : 360–72. http://dx.doi.org/10.1097/00005650-199204000-00006.

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Park, You Jeong, Behzad Etemad, Hayat Ahmed, Vivek Naranbhai, Evgenia Aga, Ronald J. Bosch, John W. Mellors et al. « Impact of HLA Class I Alleles on Timing of HIV Rebound After Antiretroviral Treatment Interruption ». Pathogens and Immunity 2, n^o 3 (27 novembre 2017) : 431. http://dx.doi.org/10.20411/pai.v2i3.222.

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Identifying host determinants associated with HIV reservoir size and viral rebound timing after an analytic treatment interruption (ATI) is an important step in the search for an HIV functional cure. A pooled analysis of 103 participants from four AIDS Clinical Trials Group ATI studies to identify the association between HLA class I alleles with HIV reservoir size and viral rebound timing. Total HIV DNA and cell-associated HIV RNA (CA-RNA) were quantified in pre-ATI peripheral blood mononuclear cell samples, and residual plasma viremia was measured using the single-copy assay. HLA class I typing was performed and we generated an odds ratio (OR) of predicted HLA effect on HIV viremia control for each individual and compared this with time to viral rebound, and levels of HIV DNA and CA-RNA. There was no significant association between the HLA ORs and levels of HIV DNA or CA-RNA, but carriage of protective HLA-B alleles (lower OR scores) was associated with delayed viral rebound (P=0.02). Higher OR scores at the HLA-C locus were associated with longer duration of ART treatment (P=0.01) and this trend was also seen with the combined OR score (P=0.007). Individuals with protective HLA-B alleles had delayed viral rebound after treatment interruption that was not explained by differences in baseline reservoir size. The results indicate the vital role of cellular host immunity in preventing HIV rebound and the importance of taking into account the HLA status of study participants being evaluated in HIV cure trials.

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Decool, Gauthier, Benjamin Bouchacourt, Claude Preudhomme, Gérard Sebahoun et Valérie Bardet. « French Group of Cellular Hematology, Aix en Provence, 17-19 May 2017 ». Hématologie 23, n^o 5 (septembre 2017) : 293–97. http://dx.doi.org/10.1684/hma.2017.1288.

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Peijnenburg, A., S. J. Gobin, M. C. van Eggermond, B. C. Godthelp, N. van Graafeiland et P. J. van den Elsen. « Introduction of exogenous class II trans-activator in MHC class II-deficient ABI fibroblasts results in incomplete rescue of MHC class II antigen expression. » Journal of Immunology 159, n^o 6 (15 septembre 1997) : 2720–27. http://dx.doi.org/10.4049/jimmunol.159.6.2720.

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Abstract Previously, we have shown that fibroblasts established from type III bare lymphocyte syndrome patient ABI are characterized by the absence of MHC class II gene expression and a strongly reduced amount of MHC class I transcripts. Complementation analysis has suggested that the gene defective in these ABI fibroblasts is different from that encoding the class II trans-activator (CIITA), which has been attributed an essential role in both constitutive and inducible expression of MHC class II genes. In the present study it is shown by reverse transcriptase-PCR analysis that the amount of CIITA transcripts in ABI fibroblasts is greatly reduced compared with that in fibroblasts derived from a healthy individual. Transient cotransfection of a construct in which CIITA is under the control of a constitutive promoter with an HLA-DRA promoter-luciferase reporter plasmid resulted in enhanced luciferase expression in ABI fibroblasts. Furthermore, ABI fibroblasts stably transfected with CIITA re-express functional HLA-DR Ags, but do not express HLA-DQ and DP Ags at the cell surface. Comparison of these data with those obtained for normal fibroblasts and fibroblasts defective for CIITA indicate that the gene defect and the resulting lack of MHC class II expression in ABI fibroblasts can only partly be corrected by the introduction of CIITA. Furthermore, DNase I hypersensitivity analysis of ABI fibroblasts has revealed a closed chromatin structure in the promoter region of the MHC class II DRA gene. However, CIITA transfection resulted in an open DNA configuration, which suggests a role for CIITA in provoking changes in the chromatin structure of the DRA gene.

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Adams, Sharon D., Kathleen C. Barracchini, Toni B. Simonis, David Stroncek et Francesco M. Marincola. « High Throughput Hla Sequence-Based Typing (Sbt) Utilizing the Abi Prism® 3700 Dna Analyzer ». Tumori Journal 87, n^o 2 (mars 2001) : 40–43. http://dx.doi.org/10.1177/030089160108700228.

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Aims and background The genetic complexity of the human major histocompatibility complex (MHC) has required the development of various molecular typing methods. The purpose of this paper is to compare the results of two of these molecular methods: sequenced based typing (SBT) and polymerase chain reaction (PCR) using sequence specific primers (PCR-SSP). Methods The SBT method described utilizes an ABI Prism® 3700 DNA Analyzer, which has been designed fro high throughput production of sequence data through highly automated operation with significant walk-away time. The ABI Prism® 3700 DNA Analyzer is a 96-capillary electrophoresis instrument with the capability of running four 96-well plates black to back in a sixteen-hour period. Potentially, data from this machine can produce Class I sequences for A or B loci for 64 samples in this time frame. The SBT method encompassed exons 2, 3, and 4 with forward and reverse sequence orientation reactions using the PE Biosystems HLA-A and HLA-B Sequenced Based Typing Kits (PE Applied Biopsystems/Perkin-Elmer, Foster City, CA, USA). Most SBT methods previously employed only gather data from exons 2 and 3 which distinguishes most of the polymorphism necessary to identify the majority of alleles in the HLA region. However, in an effort to discern numerous null alleles in the HLA region, exon 4 data is also included. The PCR-SSP method utilized consists of one 96 well tray, with 95 primer mixes and one negative control, per sample designed to produce an intermediate/high resolution HLA-A, B typing. Results Data from one 96-well capillary run on the ABI Prism® 3700 DNA Analyzer, which consists of results from 16 samples for HLA-A or HLA-B loci, was compared to data derived from sixteen HLA-A and HLA-B PCR-SSP typings. 75% of loci tested achieved a higher resolution HLA typing by the SBT method. Discussion The ability to provide allele level HLA typing results can have significant functional implications for the bone marrow transplant community and numerous vaccine studies.

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Furnback, Wesley, YiXi Chen, Peng Dong, Bruce Wang, Wajeeha Ansari, Claudie Charbonneau et Hengjing Dong. « 1604. Cost-Effectiveness of Ceftazidime-Avibactam for Patients with Hospital-Acquired Pneumonia Caused by Multi-Drug Resistant Enterobacteriaceae or Pseudomonas in China ». Open Forum Infectious Diseases 7, Supplement_1 (1 octobre 2020) : S797—S798. http://dx.doi.org/10.1093/ofid/ofaa439.1784.

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Abstract Background To estimate the cost-effectiveness of ceftazidime-avibactam (CAZ-AVI) for the treatment of hospital-acquired pneumonia (HAP) including ventilator-associated pneumonia (VAP) caused by multi-drug resistant enterobacteriaceae (MDRE) or MDR pseudomonas aeruginosa (MDRPA) in China. Methods A previously published patient-level simulation model was localized to China to estimate the cost-effectiveness of first-line CAZ-AVI compared to meropenem from a healthcare perspective. Patients flowed through the model which evaluates resistance status, response, and adverse events (AEs), which can all lead to a treatment switch. Second-line therapy of colistin plus high dose meropenem was used for both arms. Resistance rates were 0.7% (CAZ-AVI) and 7.6% (meropenem) for MDRE, and 10.7% (CAZ-AVI) and 35.5% (meropenem) for MDRPA. Effectiveness rates for CAZ-AVI and meropenem were based on a randomized, double-blind, phase 3 clinical trial. All cost data, including drugs, AEs, and hospitalization were localized to China. Utility values were based on response and sourced from the literature. Costs and benefits were discounted at 5% over the five year time horizon. Results At a cost-effectiveness threshold of three-times GDP per capita, CAZ-AVI was cost-effective compared to meropenem for HAP/VAP caused by both MDRE and MDRPA with ICERs of ¥147,500 and ¥30,496, respectively. Specifically, CAZ-AVI had ¥13,699 and 0.09 additional total costs and QALYs, respectively, within MDRE; ¥5,207 and 0.17 additional total costs and QALYs, respectively, within MDRPA. Length of stay was reduced by 0.65 days and 1.37 in the CAZ-AVI arms of the MDRE and MDRPA analyses, respectively. Conclusion CAZ-AVI is a cost-effective alternative to meropenem in the treatment of HAP/VAP caused by MDRE or MDRPA in China. Disclosures Wesley Furnback, BA, Pfizer (Consultant) YiXi Chen, MSc, Pfizer (Employee) Peng Dong, PhD, Pfizer (Employee) Bruce Wang, PhD, Pfizer (Consultant) Wajeeha Ansari, MSc, Pfizer (Employee) Claudie Charbonneau, PhD, Pfizer (Employee) Hengjing Dong, MD, Pfizer (Other Financial or Material Support, Honorarium)

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Habibi, Azwar Riza. « Api Service Infrastructure Using Kubernetes And Terraform Based On Microservices Ngoorder.Id ». SinkrOn 7, n^o 3 (30 juillet 2022) : 1008–16. http://dx.doi.org/10.33395/sinkron.v7i3.11522.

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The growing number of ngorder.id service users causes traffic to Api Ngorder to be higher, so a new infrastructure is needed in order to maintain Api Ngorder uptime during high traffic and also maintain service stability. In the implementation process, Api scripts that are currently running on a monolith cluster will be divided into several categories and will be split into several kubernetes clusters. To support autoscale, a Horizontal Pod Autoscaler was added, and to route traffic it would use the Api Gateway from Amazon Web Service. In this infrastructure test, it is done by testing the logic script function using Katalon Studio and testing at the infrastructure level by doing a crash test in the form of failing to deploy and terminating the pod, as well as performing a stress test to test autoscaling in the cluster, the entire test can be run by performing a stress test on the php service pods. by setting the autoscaler parameter Memory Utilization Percentage 125%, 150% and 250%, proving that the HorizontalPodAutoscaler (HPA) as an autoscaler handler can function according to the targets and parameters that have been determined.

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Bartmann, Catharina, Markus Junker, Sabine E. Segerer, Sebastian F. Häusler, Mathias Krockenberger et Ulrike Kämmerer. « CD33+/HLA-DRnegand CD33+/HLA-DR+/−Cells : Rare Populations in the Human Decidua with Characteristics of MDSC ». American Journal of Reproductive Immunology 75, n^o 5 (3 février 2016) : 539–56. http://dx.doi.org/10.1111/aji.12492.

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Ayuk-Arrey, Arrey-Takor, Isha Darbari, Allistair Abraham et Robert Sheppard Nickel. « HLA Typing Status of Hospitalized Pediatric Patients with Sickle Cell Disease : Impact of Socioeconomics and an Initiative to Offer Typing to All Patients with Siblings ». Blood 138, Supplement 1 (5 novembre 2021) : 2969. http://dx.doi.org/10.1182/blood-2021-153807.

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Abstract Background: Hematopoietic stem cell transplant (HSCT) using an HLA-identical sibling donor is a well-established cure for sickle cell disease (SCD). Historically, HSCT was only offered to patients with SCD who had suffered severe complications; however, given improved HSCT outcomes, it is now reasonable to consider HSCT for most patients with SCD who have an HLA-identical sibling. Thus, HLA typing of all full siblings of patients with SCD should be a clinical priority to ensure patients are aware of and have access to this therapeutic option. The primary objectives of this study are to describe the baseline prevalence of HLA typing among a cohort of hospitalized pediatric patients with SCD and to evaluate whether having had HLA typing is associated with certain characteristics. Secondarily, the study describes the acceptability of HLA typing among patients with a healthy (non-SCD) full sibling who had not already had HLA typing at baseline after dedicated outreach to these families. Methods: Between January 1, 2020 and December 31, 2020 a REDCap database of all hospitalized patients with SCD was prospectively maintained. Patient demographic and clinical information was abstracted via retrospective chart review. To evaluate socioeconomic status, a neighborhood area deprivation index (ADI) was determined for each patient using their home address and the Neighborhood Atlas website (https://www.neighborhoodatlas.medicine.wisc.edu/). ADI is a validated ranking (0-100) of Census Block Groups, considering income, education, employment, and housing quality. A higher ADI represents greater socioeconomic disadvantage. As part of a clinical outreach initiative, patients' families who had not already had typing at the time of their hospitalization were contacted to determine if the patient has a healthy full sibling and, if applicable, offer sibling HLA typing. This outreach was originally planned to occur in person at the time of hospitalization or clinic follow-up, but due the COVID-19 pandemic it was paused and when resumed conducted mostly via telephone. Results: During the 52-week study period, 291 patients with SCD were hospitalized at the study pediatric institution. Seventy-one patients (24%) had already completed HLA typing at the time of their first hospitalization during the study period. These patients with HLA typing at baseline were significantly more likely to have a diagnosis of sickle cell anemia (HbSS/HbSβ 0 genotype) and be on disease-modifying therapy (hydroxyurea or chronic transfusion) compared to patients without typing at baseline (Table). Age and sex were not significantly different between patients with and without typing (Table). The group of patients who did not have HLA typing at baseline had a significantly greater ADI (mean 29.7 vs. 24.0, p=.008) and proportion of patients with a high disadvantage ADI score ≥40 (23% vs. 10%, p=.02), Figure. Of the 220 patients with no history of HLA typing, the sibling status of 187 patients was determined via outreach to these families as of July 2021. Among these 187 patients, 81 (43%) reported having a healthy full sibling. Among these 81 patients with siblings, after being offered family HLA typing, 42 (52%) were interested and referred for HLA typing, 29 (36%) were undecided, and 10 (12%) declined typing. Conclusion: Hospitalized pediatric patients with SCD who had already been HLA typed were more likely to have a severe SCD genotype and be on disease-modifying therapy as expected. Patients who had not had HLA typing were more likely to live in a socioeconomically disadvantaged neighborhood. This finding suggests that dedicated outreach to all families regarding HLA typing is needed. Our clinical initiative to offer typing to all hospitalized patients with healthy full siblings was feasible, with a majority of families interested in pursuing HLA typing. Continued work is needed to ensure patients with SCD have equal access to curative therapy regardless of socioeconomic status. Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

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Beishon, Lucy C., Kannakorn Intharakham, Victoria J. Haunton, Thompson G. Robinson et Ronney B. Panerai. « The Interaction of Dynamic Cerebral Autoregulation and Neurovascular Coupling in Cognitive Impairment ». Current Alzheimer Research 18, n^o 14 (décembre 2021) : 1067–76. http://dx.doi.org/10.2174/1567205019666211227102936.

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Background: Dynamic cerebral autoregulation (dCA) remains intact in both ageing and dementia, but studies of neurovascular coupling (NVC) have produced mixed findings. Objective: We investigated the effects of task-activation on dCA in healthy older adults (HOA), and patients with mild cognitive impairment (MCI) and Alzheimer’s Disease (AD). Methods: Resting and task-activated data from thirty HOA, twenty-two MCI, and thirty-four AD were extracted from a database. The autoregulation index (ARI) was determined at rest and during five cognitive tasks from transfer function analysis. NVC responses were present where group-specific thresholds of cross-correlation peak function and variance ratio were exceeded. Cumulative response rate (CRR) was the total number of positive responses across five tasks and two hemispheres. Results: ARI differed between groups in dominant (p=0.012) and non-dominant (p=0.042) hemispheres at rest but not during task-activation (p=0.33). ARI decreased during language and memory tasks in HOA (p=0.002) but not in MCI or AD (p=0.40). There was a significant positive correlation between baseline ARI and CRR in all groups (r=0.26, p=0.018), but not within sub-groups. Conclusion: dCA efficiency was reduced in task-activation in healthy but not cognitively impaired participants. These results indicate differences in neurovascular processing in healthy older adults relative to cognitively impaired individuals.

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Hoşgün, Derya, et Semih Aydemir. « Factors affecting 90-day mortality in community and hospital acquired pneumonia patients with or without acute kidney injury ». African Health Sciences 22, n^o 3 (28 octobre 2022) : 567–77. http://dx.doi.org/10.4314/ahs.v22i3.61.

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Background: AKI is a significant risk factor for mortality. Inflammatory markers are commonly used in the prediction of prognosis in pneumonia patients. The present study aimed to evaluate the prevalence of AKI in hospitalized CAP and HAP patients and to investigate the role of inexpensive, practical, routinely measured serum biomarkers in predicting 90-day mortality. Materials and Methods: The retrospective study included 381 patients in CAP patients and HAP patients who were hospitalized in our Chest Diseases clinic or ICU. Results: Ninety-day mortality occurred in 115 (30.2%) patients (CAP, 28.7%; HAP, 34.7%). AKI was detected in 25.5% of the patients. On multivariate logistic regression analysis, the 90-day mortality risk was 0.931, 1.05, 0.607, and 1.999 times greater in patients with an increased APACHE II score and increased WBC, 1-h creatinine, and 48-h creatinine levels, respectively. In CAP patients, the 90-day mortality risk was 0.296, 0.539, and 1.966 times greater in patients with an increased CURB-65 score and elevated 1-h and 48-h creatinine levels, respectively. In HAP patients, however, the 90-day mortality risk was 3.554 times greaterin patients with an increased 48-h creatinine level. Conclusion: Novel practical scoring systems based on serum creatinine levels are needed for the prediction of long-term prognosis in pneumonia patients. Keywords: Community Acquired Pneumonia; Hospital Acguired Pneumonia; Acute Kidney İnjury.

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Zhang, Wenjie, Hong Wang, Xiaoye Zhang, Liping Huang, Yue Peng, Zhaodong Liu, Xiao Zhang et Huizheng Che. « Aerosol–cloud interaction in the atmospheric chemistry model GRAPES_Meso5.1/CUACE and its impacts on mesoscale numerical weather prediction under haze pollution conditions in Jing–Jin–Ji in China ». Atmospheric Chemistry and Physics 22, n^o 23 (30 novembre 2022) : 15207–21. http://dx.doi.org/10.5194/acp-22-15207-2022.

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Abstract. The representation of aerosol–cloud interaction (ACI) and its impacts in the current climate or weather model remains a challenge, especially for severely polluted regions with high aerosol concentration, which is even more important and worthy of study. Here, ACI is first implemented in the atmospheric chemistry model GRAPES_Meso5.1/CUACE by allowing for real-time aerosol activation in the Thompson cloud microphysics scheme. Two experiments are conducted focusing on a haze pollution case with coexisting high aerosol and stratus cloud over the Jing–Jin–Ji region in China to investigate the impact of ACI on the mesoscale numerical weather prediction (NWP). Study results show that ACI increases cloud droplet number concentration, water mixing ratio, liquid water path (CLWP), and optical thickness (COT), as a result improving the underestimated CLWP and COT (reducing the mean bias by 21 % and 37 %, respectively) over a certain subarea by the model without ACI. A cooling in temperature in the daytime below 950 hPa occurs due to ACI, which can reduce the mean bias of 2 m temperature in the daytime by up to 14 % (∼ 0.6 ∘C) in the subarea with the greatest change in CLWP and COT. The 24 h cumulative precipitation in this subarea corresponding to moderate-rainfall events increases, which can reduce the mean bias by 18 %, depending on the enhanced melting of the snow by more cloud droplets. In other areas or periods with a slight change in CLWP and COT, the impact of ACI on NWP is not significant, suggesting the inhomogeneity of ACI. This study demonstrates the critical role of ACI in the current NWP model over the severely polluted region and the complexity of the ACI effect.

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McNEARNEY, TERRY A., SONYA E. HUNNICUTT, MICHAEL FISCHBACH, ALAN W. FRIEDMAN, MARTHA AGUILAR, CHUL W. AHN, JOHN D. REVEILLE et al. « Perceived Functioning Has Ethnic-specific Associations in Systemic Sclerosis : Another Dimension of Personalized Medicine ». Journal of Rheumatology 36, n^o 12 (16 novembre 2009) : 2724–32. http://dx.doi.org/10.3899/jrheum.090295.

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Objective.To measure self-reported physical and mental functioning and associated clinical features at study entry in 3 ethnic groups with systemic sclerosis (SSc).Methods.Sixty Hispanic, 39 African American, and 104 Caucasian patients with recent-onset SSc (< 5 yrs) were assessed for perceived physical and mental functioning, using the Medical Outcomes Study Short Form-36 (SF-36) and Scleroderma-Health Assessment Questionnaire (Scleroderma-HAQ). Socioeconomic, demographic, clinical, immunologic, immunogenetic, behavioral, and psychological variables (Interpersonal Support Evaluation List, ISEL; Illness Behavior Questionnaire, IBQ; and Arthritis Helplessness Index, AHI) were analyzed by linear regression models for associations with SF-36 and mHAQ scores as dependent variables.Results.Perceived physical functioning scores had ethnic-specific associations with AHI > fatigue scores > IBQ > clinical variables (hypertension, skin score, and percentage predicted DLCO). Scleroderma-HAQ scores had ethnic-specific associations with IBQ > AHI scores > most clinical and laboratory variables. Decreased mental component summary (MCS) scores associated with AHI > ISEL. Ethnic-specific immunogenetic variables HLA-DQB1*0202 (Caucasian) and HLA-DRB 1*11 (African American), and HLA-DQA1*0501 (Hispanic) also associated with MCS. Antinuclear autoantibodies, anti-topoisomerase I, and RNA polymerases I and III also demonstrated associations with functioning in African American and Hispanic groups.Conclusion.Clinical, psychosocial, and immunogenetic variables had ethnic-specific associations with perceived physical and mental functioning. Consideration of ethnic-specific psychological and behavioral support in designing more personalized, relevant therapeutic interventions for the patient may improve therapeutic efficacy in SSc.

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Saponaro, Giulia, Pekka Kolmonen, Larisa Sogacheva, Edith Rodriguez, Timo Virtanen et Gerrit de Leeuw. « Estimates of the aerosol indirect effect over the Baltic Sea region derived from 12 years of MODIS observations ». Atmospheric Chemistry and Physics 17, n^o 4 (28 février 2017) : 3133–43. http://dx.doi.org/10.5194/acp-17-3133-2017.

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Abstract. Retrieved from the Moderate Resolution Imaging Spectroradiometer (MODIS) on-board the Aqua satellite, 12 years (2003–2014) of aerosol and cloud properties were used to statistically quantify aerosol–cloud interaction (ACI) over the Baltic Sea region, including the relatively clean Fennoscandia and the more polluted central–eastern Europe. These areas allowed us to study the effects of different aerosol types and concentrations on macro- and microphysical properties of clouds: cloud effective radius (CER), cloud fraction (CF), cloud optical thickness (COT), cloud liquid water path (LWP) and cloud-top height (CTH). Aerosol properties used are aerosol optical depth (AOD), Ångström exponent (AE) and aerosol index (AI). The study was limited to low-level water clouds in the summer. The vertical distributions of the relationships between cloud properties and aerosols show an effect of aerosols on low-level water clouds. CF, COT, LWP and CTH tend to increase with aerosol loading, indicating changes in the cloud structure, while the effective radius of cloud droplets decreases. The ACI is larger at relatively low cloud-top levels, between 900 and 700 hPa. Most of the studied cloud variables were unaffected by the lower-tropospheric stability (LTS), except for the cloud fraction. The spatial distribution of aerosol and cloud parameters and ACI, here defined as the change in CER as a function of aerosol concentration for a fixed LWP, shows positive and statistically significant ACI over the Baltic Sea and Fennoscandia, with the former having the largest values. Small negative ACI values are observed in central–eastern Europe, suggesting that large aerosol concentrations saturate the ACI.

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Cirilo, Anthony, Jordan Kohn, Gavrila Ang, Meredith Pung, Emily Troyer, Christopher Pruitt, Laura Redwine et Suzi Hong. « Allostatic Load Following Short-Term Intervention : Cognition in Older Hypertensive Adults ». Innovation in Aging 5, Supplement_1 (1 décembre 2021) : 1023–24. http://dx.doi.org/10.1093/geroni/igab046.3664.

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Abstract Allostatic load (AL), a measure of cumulative effect of prolonged stressors across physiological systems, is consistently associated with adverse health outcomes. Greater AL is correlated with functional decline in aging, but effects of behavioral interventions, such as Tai Chi (TC), on AL in older adults in a short-term is unknown. To investigate the effects of TC practice on AL and cognitive function and an AL-cognition relationship, older adults (60-95 years) with hypertension were recruited and randomly assigned to 12-week TC or Healthy Aging Practice-centered Education (HAP-E) classes. The AL index (ALI) included: SBP and DBP; urinary epinephrine and norepinephrine; plasma inflammatory biomarkers (CRP, IL-6); metabolic biomarkers (HDL, total cholesterol, triglycerides, HbA1c); and BMI. The Montreal Cognitive Assessment (MoCA) was administered to assess cognitive function. Generalized linear mixed-effects models, adjusted for age, race, education, and intervention attendance, was used. Pre- and post-intervention ALI did not change significantly in TC (2.61 (1.48) to 2.76 (1.62)) or HAP-E (2.84 (1.61) to 2.66 (1.86)). High ALI was associated with lower MoCA scores, indicating poorer cognitive performance (IRR=0.96; 95% CI: 0.93-0.98; p=0.002) across the time points. Of note, the MoCA scores did not significantly change across time (25.4 (3.2) to 26.0 (3.0)). 12-week TC or HAP-E interventions did not lead to a significant change in ALI or cognitive performance in our population. However, our findings show greater AL theoretically attributed to chronic stress is associated with cognitive functioning in older adults consistently over about 4 months.

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Tsatsanis, Christos, Eirini Dermitzaki, Pavlina Avgoustinaki, Niki Malliaraki, Vasilis Mytaras et Andrew Margioris. « The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis ». HORMONES 14, n^o 4 (15 octobre 2015) : 549–62. http://dx.doi.org/10.14310/horm.2002.1649.

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Treudler, Regina, et Jan C. Simon. « Hymenopterengiftallergie – Wer kann wann sein Notfallset ablegen oder lieber nicht ? » Kinder- und Jugendmedizin 20, n^o 05 (octobre 2020) : 285–86. http://dx.doi.org/10.1055/a-1244-2541.

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ZUSAMMENFASSUNGSchwere Soforttypreaktionen aufgrund einer Hymenopterengiftallergie (HGA) sollen mit einer intramuskulären Adrenalingabe behandelt werden. Die Indikation zur Verordnung eines Adrenalin-Autoinjektors (AAI) besteht bei Patienten, die an Mastzellerkrankungen leiden, eine erhöhte Serumtryptase haben und/oder bei Patienten ohne Venomimmuntherapie (VIT), bei denen mindestens zwei Organsysteme betroffen waren. Die Verordnung eines AAI kann ebenfalls in weiteren Risikosituationen vor, während oder nach Ende einer VIT erwogen werden.

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Zappernick, Taissa, Robbie Christian, Sharanie Sims, Brigid Wilson, Federico Perez, Robert Bonomo et Robin Jump. « Influence of Antibiotic Susceptibility Testing on Antibiotic Choice in Hospital-Acquired and Ventilator-Associated Pneumonia ». Infection Control & ; Hospital Epidemiology 41, S1 (octobre 2020) : s520—s521. http://dx.doi.org/10.1017/ice.2020.1204.

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Background: The survival of patients with hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) is largely determined by the timely administration of effective antibiotic therapy. Guidelines for the treatment HAP and VAP recommend empiric treatment with broad-spectrum antibiotics and tailoring of antibiotic therapy once results of microbiological testing are available. Objective: We examined the influence of bacterial identification and antibiotic susceptibility testing on antibiotic therapy for patients with HAP or VAP. Methods: We used the US Veterans’ Health Administration (VHA) database to identify a retrospective cohort of patients diagnosed with HAP or VAP between fiscal year 2015 and 2018. We further analyzed patients who were started on empiric antibiotic therapy, for whom microbiological test results from a respiratory sample were available within 7 days and who were alive within 48 hours of sample collection. We used the antibiotic spectrum index (ASI) to compare antibiotics prescribed the day before and the day after availability of bacterial identification and antibiotic susceptibility testing results. Results: We identified 4,669 cases of HAP and VAP in 4,555 VHA patients. The median time from respiratory sample receipt in the laboratory to final result of bacterial identification and antibiotic susceptibility testing was 2.22 days (IQR, 1.31–3.38 days). The most common pathogen was Staphylococcus aureus (n = 994), with methicillin resistance in 58% of those isolates tested. The next most common pathogen was Pseudomonas spp (n = 946 isolates). The susceptibility of antipseudomonal antibiotics, when tested, was as follows: 64% to carbapenems, 74% to cephalosporins, 75% to β-lactam/β-lactamase inhibitors, 69% to fluoroquinolones, and 95% to amikacin. Lactose-fermenting gram-negative bacteria (296 Escherichia coli and 360 Klebsiella pneumoniae) were also common. Among the 3,094 cases who received empiric antibiotic therapy, 607 (20%) had antibiotics stopped the day after antibiotic susceptibility results became available, 920 (30%) had a decrease in ASI, 1,075 (35%) had no change in ASI, and 492 (16%) had an increase in ASI (Fig. 1). Among the 1,098 patients who were not started on empiric antibiotic therapy, only 154 (14%) were started on antibiotic therapy the day after antibiotic susceptibility results became available. Conclusions: Changes in antibiotic therapy occurred in at least two-thirds of cases the day after bacterial identification and antibiotic susceptibility results became available. These results highlight how respiratory cultures can inform the treatment and improve antibiotic stewardship for patients with HAP/VAP.Funding: This study was supported by Accelerate Diagnostics.Disclosures: None

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Madbouly, Abeer, Tao Wang, Mark Albrecht, Vanja Paunic, Michael D. Haagenson, Cynthia Vierra-Green, Katharina Fleischhauer et al. « Investigating Effect of Genetic Admixture and Donor/Recipient Genetic Disparity on Transplant Outcomes ». Blood 126, n^o 23 (3 décembre 2015) : 3229. http://dx.doi.org/10.1182/blood.v126.23.3229.3229.

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Abstract Aim Survival after hematopoietic cell transplantation (HCT) is dependent on donor/recipient (D/R) HLA matching. However disparities in survival were reported for some ethnicities despite comparable HLA matching. Individual ethnicities/races, as reported through self-identification, can change over time. Most studies have shown that African-American recipients (AAFA race) experience worse survival. Another way to investigate ancestry is to use Ancestry Informative Marker SNPs (AIMs), providing ancestral admixture. We hypothesized that information on donor and recipient genetic admixture may be used to evaluate D/R genetic disparity and that this may be associated with outcomes of HLA matched unrelated donor HCTs. Methods Study population included 1295 10/10 HLA matched D/R pairs receiving HCT for AML, ALL, CML and MDS between 1995 and 2011. Samples were genotyped for 500 AIMs. We estimated African (AFR), European (EUR), Asian (ASI) and South European/Amerindian (SE/A) admixtures for donors and recipients using STRUCTURE at K=4 clusters. Tables 1 and 2 show the admixture distributions in each of the self-identified race groups. To model D/R genetic disparity we ran principal components analysis (PCA) on the D/R genotypes, then calculated the pairwise Euclidean distance between a subset of PCA eigenvectors of each D/R duo. Multivariate analyses were performed using Cox proportional hazards models for overall survival (OS), disease free survival (DFS), relapse, transplant related mortality (TRM), acute and chronic graft versus host disease (GVHD) for admixture and genetic disparity. Results For transplant recipients, increasing AFR admixture was associated with worse OS and TRM at p<0.01 and DFS at p=0.02 (Figure 1). Recipient EUR and SE/A admixtures failed linearity test with p=0.04 and p<0.0001 respectively and were not further analyzed. For donors, increasing AFR admixture was associated with worse OS, DFS and TRM at p<0.01 (table 4). No associations were noted for donor ASI, EUR and SE/A. We tested for a cut point for AFR admixture that best associated with survival. For recipients, the optimal cut point was > 14% AFR admixture. This only included 2.8% of the population (N=34 recipients) but 90% of the African-American self-identified recipients. For donors the cut point was > 23% AFR admixture which only included 1.9% of the population (N=24 donors) but 89% of African-American self-identified donors. Recipients and donors with high AFR admixture were highly confounded and numbers were too small to explore whether recipient or donor AFR admixture was more important. No significant associations were observed for D/R pairwise genetic distance and clinical outcomes. Conclusion While no significant associations were found for the D/R genetic distance used here, increasing AFR admixture in recipient and donor associated with increased risk of overall mortality, TRM and decreased DFS. The observed effect was attributed to 2.8% of the recipient and 1.9% of donor population with higher AFR admixture, groups that contained >89% of the self-identified African-Americans. Our findings are consistent with studies showing that self-identified African-Americans are associated with suboptimal HCT outcomes. It is still unclear whether the deleterious effect of AFR admixture is genetic in nature or due to other non-genetic factors such as access to healthcare or other socio-economic factors mostly pertinent to recipients. Table 1. Admix in recip race groups Race Admix AFR EUR SE/A ASI Median IQR Med IQR Med IQR Med IQR AAFA N=26 0.81 0.7, 0.9 0.08 0.03, 0.1 0.06 0.02, 0.1 0.005 0.003, 0.008 CAU N=1113 0.004 0.002, 0.007 0.97 0.9, 0.98 0.015 0.007, 0.05 0.004 0.002, 0.007 HIS N= 63 0.005 0.003, 0.02 0.03 0.01, 0.14 0.764 0.5, 0.9 0.08 0.015, 0.2 API N= 20 0.005 0.002, 0.01 0.005 0.001, 0.01 0.008 0.002, 0.2 0.97 0.7, 0.99 Table 2. Admix in donor race groups Race Admix AFR EUR SE/A ASI Med IQR Med IQR Med IQR Med IQR AAFA N= 18 0.82 0.7, 0.9 0.1 0.03, 0.14 0.05 0.03, 0.06 0.004 0.002, 0.005 CAU N= 1077 0.004 0.002, 0.007 0.97 0.9, 0.98 0.014 0.007, 0.05 0.004 0.002, 0.008 HIS N= 60 0.006 0.003, 0.02 0.04 0.02, 0.48 0.7 0.3, 0.9 0.05 0.007, 0.2 API N=22 0.003 0.002, 0.005 0.003 0.002, 0.03 0.002 0.002, 0.03 0.98 0.8, 0.99 Figure 1. Multivariate analysis evaluating the effects of recip AFR admix on outcomes. Figure 1. Multivariate analysis evaluating the effects of recip AFR admix on outcomes. Figure 2. Multivariate analysis evaluating the effects of donor AFR admix on outcomes. Figure 2. Multivariate analysis evaluating the effects of donor AFR admix on outcomes. Disclosures Majhail: Gamida Cell Ltd.: Consultancy; Anthem Inc.: Consultancy. Lee:Kadmon: Consultancy; Bristol-Myers Squibb: Consultancy.

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Janjani, Parisa, Mohammad Reza Majzoobi, Amir Sanjabi, Mojtaba Movahed, Alireza Rai, Khodamorad Momeni, Reza Heidari Moghadam, Mohammed Rouzbahani, Mhammadreza Saidi et Nahid Salehi. « Assessing the adherence to treatment among patients with cardiovascular diseases in Kermanshah, Iran ». Health Promotion Perspectives 11, n^o 1 (7 février 2021) : 80–86. http://dx.doi.org/10.34172/hpp.2021.11.

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Background: The present study aimed to investigate the psychological determinants of adherence to treatment among patients with cardiovascular diseases (CVDs) referring to Imam Ali Hospital in Kermanshah, Iran. Methods: This cross-sectional study was conducted on 227 patients (mean age=58.10, SD = 13.44) with CVDs, randomly selected amongst those admitted to Imam Ali cardiovascular center of Kermanshah in 2018. Data were collected through Meaning in Life Questionnaire (MLQ), the Jefferson Scale of Patient’s Perceptions of Physician Empathy (JSPPPE), the Illness Perception Questionnaire (IPQ), and Adherence to Treatment Questionnaire. The relationships between the criterion and predictor variables were assessed using Pearson correlation coefficient and linear regression (stepwise method) in IBM SPSS Statistics-23. Results: The adherence to treatment was associated with meaning in life (r=0.367), patients’ perceptions of physician empathy (r=0.218), and illness perception (r=-0.238), at the 0.01 level. Meaning in life, patient’s perceptions of physician empathy, and illness perception explained 18.6% of the variance in adherence to treatment. Meaning in life (beta=0.367 and P≤0.001) was the most influential predictor of adherence to treatment. Additionally, there was a significant difference in the score of adherence to treatment by gender (23.46±4.42 for female vs. 24.77±3.53 for male, P = 0.030). Conclusion: The patients’ perceptions of physician empathy, meaning in life, and illness perception were important factors to predict adherence to treatment in patients with CVDs. Gender was a significant predictor of the adherence to treatment.

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Saatian, Bahman, Xiao-Ying Yu, Andrew P. Lane, Thanh Doyle, Vincenzo Casolaro et Ernst Wm Spannhake. « Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation ». American Journal of Physiology-Lung Cellular and Molecular Physiology 287, n^o 1 (juillet 2004) : L217—L225. http://dx.doi.org/10.1152/ajplung.00132.2003.

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Epithelial cells of the human respiratory tract express human leukocyte antigen (HLA) and the costimulatory molecules B7-1 and B7-2. Little is known, however, about the constitutive expression of genes encoding for the more recently identified members of the B7 homolog family of costimulatory molecules or about the influence of cellular differentiation and cytokines on their activity or on that of HLA or B7-1 and B7-2. Human nasal epithelial (HNE) cells were grown at the air-liquid interface (ALI) for 2 or 21 days to model in vivo conditions. Expression of genes for HLA-B and HLA-DR1 increased during mucociliary differentiation during this period and became more similar to HNE cells obtained fresh by brush biopsy from nasal turbinates. Gene transcripts for B7-H3 and B7-H2 were abundantly expressed in cells cultured at the ALI, but neither their activities nor that of B7-2 was significantly altered during differentiation. IFN-γ and TNF-α upregulated mRNA encoding for both HLA molecules, but not for the B7 molecules. This study describes, for the first time, the expression of B7-H3 and B7-H2 by HNE cells and thus expands the range of potential costimulatory signals through which these cells may interact with activated mucosal T lymphocytes. In addition, the results suggest that the extent of mucociliary differentiation of cultured cells may influence this capability.

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Rokita, Jan. « Wirus rozchwiania (czyli kilka uwag o politycznych konsekwencjach zarazy) ». Horyzonty Polityki 11, n^o 36 (21 octobre 2020) : 25–41. http://dx.doi.org/10.35765/hp.1973.

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CEL NAUKOWY: Celem artykułu jest analiza przewidywanych i widocznych już dzisiaj konsekwencji kryzysu pandemii w wymiarze politycznym, gospodarczym, społecznym i religijnym. PROBLEM I METODY BADAWCZE: Autor korzysta z bogatego spektrum wypowiedzi współczesnych analityków kryzysu COVID-19, dokonując przeglądu ich opinii oraz oceniając ich rzeczywiste podstawy. Przywołuje poglądy i prognozy formułowane w świecie zachodnich demokracji przez polityków, naukowców, hierarchów Kościoła. PROCES WYWODU: Proces wywodu polega na analizie współczesnych problemów związanych z zarazą w Europie i USA. Drugim stopniem analiz jest sformułowanie domniemań co do przyszłych konsekwencji kryzysu. WYNIKI ANALIZY NAUKOWEJ: Najistotniejszą konkluzją artykułu jest próba rozpoznania konsekwencji kryzysu w kluczowych dziedzinach życia zachodnich demokracji. Zdaniem autora obecny kryzys przyczynia się do wzrostu podejrzliwości społeczeństw zachodnich wobec państwa demoliberalnego, które w sytuacji pandemii stara się uwypuklić swoją skłonność do działań autorytarnych. Chodzi tu przede wszystkim o oddziaływanie w duchu interwencjonizmu gospodarczego, centralizmu, protekcjonizmu. WNIOSKI, INNOWACJE, REKOMENDACJE: Autor dochodzi do wniosku, iż obecny kryzys powoduje radykalizację istniejących już wcześniej idei. Jego zdaniem ani elity polityczne, ani też hierarchowie Kościoła nie są w stanie zachować równowagi intelektualnej wobec kryzysu COVID-19, który nazywa on kryzysem „rozchwiania”. Ostatecznie nie wiadomo, jaka czeka nas przyszłość. Póki co nie mogą nas o tym pouczyć ani współczesna nauka, ani też – tym bardziej – żadne elity polityczne.

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Nardi, Fabiola da Silva, Renata Slowik, Pryscilla Fanini Wowk, José Samuel da Silva, Geórgia Fernanda Gelmini, Tatiana Ferreira Michelon, Jorge Neumann et Maria da Graça Bicalho. « Analysis of HLA-G Polymorphisms in Couples with Implantation Failure ». American Journal of Reproductive Immunology 68, n^o 6 (25 septembre 2012) : 507–14. http://dx.doi.org/10.1111/aji.12001.

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Bichler, G., et C. J. Weijer. « A Dictyostelium anterior-like cell mutant reveals sequential steps in the prespore prestalk differentiation pathway ». Development 120, n^o 10 (1 octobre 1994) : 2857–68. http://dx.doi.org/10.1242/dev.120.10.2857.

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We have isolated Dictyostelium cell type proportioning mutants in a screen for cAMP signal transduction mutants. All mutants showed reduced numbers of prespore cells as analyzed with prespore-specific antibodies and prespore- and prestalk-specific reporter gene constructs. Formation of prestalk and prespore cells in the mutant HP1 is initially almost normal; however, many prespore cells redifferentiate as anterior-like cells leading to altered cell type proportions. Synergy experiments of HP1 transformant cells with wild-type Ax2 slugs showed the existence of stable subpopulations of cells in the prestalk and prespore regions of the slug. HP1 cells sort exclusively to the back of the prestalk and prespore zone in slugs. These cells will form the upper and lower cup regions of the culminate. Ax2 transformant cells sort to the tip of the anterior prestalk and prespore zone in HP1 slugs and will form the stalk and spores in the culminate. These experiments show that upper and lower cup derive from cells in different differentiation pathways. The lower cup cell derive from prespore cells, which redifferentiate as anterior-like cells in the back of the prespore zone. The upper cup cells derive from cells from the back of the prestalk zone. Synergy experiments showed that the mutation in HP1 results in an altered sensitivity to proportioning signals. The mutation in HP1 may result in a reduced sensitivity to cAMP, which facilitates the redifferentiation of prespore cells via anterior-like to lower cup cells and inhibits the transition from upper cup to stalk cells.

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Kang, Sang Wook, Eunkyung Oh, Wonwoo Cho, Minseok Kim, Eo Jin Park, Kyu Hwan Kwack, Kang Chung, Ok Hyung Nam, Yong Kwon Chae et Ju Yeon Ban. « HLA-G 14bp Ins/Del Polymorphism in the 3′UTR Region and Acute Rejection in Kidney Transplant Recipients : An Updated Meta-Analysis ». Medicina 57, n^o 10 (24 septembre 2021) : 1007. http://dx.doi.org/10.3390/medicina57101007.

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Background and Objectives: Acute kidney injury (AKI) affects the survival rate of kidney transplant organs and patients. Acute rejection (AR) due to AKI may lead to kidney transplantation failure. It is known that there is a relationship between human leukocyte antigen-G (HLA-G), which is involved in immune regulation, and AR in transplant patients. Moreover, 14-bp insertion/deletion polymorphism in the 3′ untranslated region (UTR) region of the HLA-G gene is known to affect HLA-G expression. However, its relationship to AR is still controversial. The aim of this study was to investigate whether HLA-G 14-bp insertion/deletion polymorphism contributed to the development of AR in kidney transplant patients using a meta-analysis. Materials and Methods: To perform our meta-analysis, eligible studies about HLA-G 14-bp insertion/deletion polymorphism and AR were searched in electronic databases until 1 June 2021. Finally, a total of 336 patients with AR and 952 patients without AR in relation to kidney transplantation were analyzed from a total of nine studies. Results: In our results, the Del allele and Ins/Del+Del/Del and Del/Del genotypes significantly increased susceptibility of AR in Asian populations [odds ratio (OR) = 2.359, 95% confidence interval (CI) = 1.568–3.550, p = 3.8 × 10−5; OR = 3.357, 95% CI = 1.769–6.370, p = 0.002; OR = 2.750, 95% CI = 1.354–5.587, p = 0.0052 in each model, respectively]. Conclusions: Evidence of the present results indicate that HLA-G 14-bp insertion/deletion polymorphism is associated with susceptibility to AR in the Asian population.

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Jain, Michael D., Hua Zhao, Reginald Atkins, Meghan A. Menges, Crystal R. Pope, Rawan Faramand, Sae Bom Lee et al. « Tumor Inflammation and Myeloid Derived Suppressor Cells Reduce the Efficacy of CD19 CAR T Cell Therapy in Lymphoma ». Blood 134, Supplement_1 (13 novembre 2019) : 2885. http://dx.doi.org/10.1182/blood-2019-131041.

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Introduction: Approximately 60% of Large B cell Lymphoma (LBCL) patients that receive CD19 CAR T cell therapy with axicabtagene ciloleucel (axi-cel) experience lymphoma progression (Locke et al. Lancet Oncol. 2019) and the likelihood of response to subsequent therapy is low (Spiegel, Dahiya et al. ASCO 2019). Target loss of CD19 is observed in less than a third of patients experiencing relapse. Alternative mechanisms of resistance to axi-cel are poorly understood. Lymphoma patients with elevated serum markers of systemic inflammation, such as ferritin and IL-6, have worse outcomes following axi-cel (Locke, Neelapu et al. Mol.Ther.2017; Faramand et al. ASH 2018). We hypothesized that suppressive monocytic myeloid derived suppressor cells (M-MDSCs), which are associated with worse chemotherapy outcomes in LBCL (Azzaoui et al. Blood 2016), and tumor driven inflammation may be present and responsible for decreased efficacy of axi-cel in LBCL. Methods: LBCL patients undergoing axi-cel treatment were enrolled onto prospective sample collection protocols. Patients were stratified for analysis into ongoing responders (complete response or partial response) or relapsed (progressive disease) after a minimum of 3 months follow-up (range 3 - 15 months). M-MDSCs, defined as a Lin-, CD11b+, CD33+, CD15-, CD14+, HLA-DRlow population, were sorted from leftover apheresis material after collection for axi-cel manufacture. M-MDSC ability to suppress proliferation of autologous T cells stimulated with CD3/CD28 coated beads was measured by 3H thymidine incorporation. Circulating peripheral blood M-MDSCs, quantified by % of live cells by flow cytometry, were measured at the time of apheresis and serially after axi-cel infusion until day 30. In vitro mouse experiments utilized a CD19-CD28 CAR and cytokine-induced bone marrow MDSCs (Thevenot et al. Immunity 2014). Cytokines were measured by ELISA and cytotoxicity against CD19 bearing cell lines used xCELLigence real-time cell analysis, as we have done previously (Li et al. JCI Insight 2018).Tumor biopsies were taken within 1 month prior to infusion of axi-cel. Limited gene expression profiling of tumor microenvironment (TME) genes used the Nanostring IO360 panel (770 genes). Analysis used nSolver to identify cell types, GSEA and differential gene expression between groups. Results: First, we demonstrated that M-MDSCs sorted from patient apheresis material suppressed the proliferation of autologous T cells (n=6). We next enumerated M-MDSCs in the peripheral blood (n = 32). M-MDSC numbers initially decreased after lymphodepleting chemotherapy but recovered to baseline levels by day +10. The level of M-MDSCs following CAR T cell therapy strongly correlated with pre-CAR T baseline levels (R = 0.871, p <0.0001), suggesting that the number of M-MDSCs present during CAR T cell expansion is dependent on factors already present before therapy began. M-MDSC levels were significantly higher in patients who subsequently relapsed, both at baseline (p= 0.01) and after axi-cel (p=0.04), as compared to patients with durable response. Mouse MDSCs were able to suppress CAR T cell IFN-gamma excretion (p<0.0001) and cytotoxicity (p<0.0001) in vitro. To evaluate the role of the TME we interrogated limited set gene expression profiling on patient (n=27) pre-axi-cel tumor biopsies. By cell type scoring, the macrophage gene score was significantly higher in patients who relapsed after CAR T therapy (p <0.001). By differential gene expression and gene set enrichment, patients who relapsed had a significantly higher expression (p <0.01) of multiple genes indicative of chronic interferon (IFN) signaling including higher levels of OAS2, OAS3, IFI6 and IFIT1, as well as the IFN-stimulated macrophage gene SIGLEC-1/CD169. Conclusions: Systemic inflammatory myeloid cytokines, circulating M-MDSCs in the blood and chronic IFN in the TME all associate with LBCL relapse after axi-cel CAR T cell therapy. Our observations support that CAR T cells can be suppressed by baseline patient and tumor-related factors and strategies to overcome these factors should be targeted to improve patient outcomes. MDJ and HZ contributed equally. Disclosures Jain: Kite/Gilead: Consultancy. Bachmeier:Kite/Gilead: Speakers Bureau. Chavez:Novartis: Membership on an entity's Board of Directors or advisory committees; Genentech: Speakers Bureau; Kite Pharmaceuticals, Inc.: Membership on an entity's Board of Directors or advisory committees; Janssen Pharmaceuticals, Inc.: Speakers Bureau. Shah:Jazz Pharmaceuticals: Research Funding; Incyte: Research Funding; Kite/Gilead: Honoraria; Celgene/Juno: Honoraria; Pharmacyclics: Honoraria; Adaptive Biotechnologies: Honoraria; Spectrum/Astrotech: Honoraria; Novartis: Honoraria; AstraZeneca: Honoraria. Mullinax:Iovance: Research Funding. Davila:Celgene: Research Funding; GlaxoSmithKline: Consultancy; Precision Biosciences: Consultancy; Novartis: Research Funding; Atara: Research Funding; Bellicum: Consultancy; Adaptive: Consultancy; Anixa: Consultancy. Locke:Kite: Other: Scientific Advisor; Novartis: Other: Scientific Advisor; Cellular BioMedicine Group Inc.: Consultancy.

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López-González, Luis. « Studies in Honor of Robert ter Horst eds. by Eleanor Ter Horst, Edward H. Friedman, and Ali S. Zaidi ». Hispania 101, n^o 4 (2018) : 655–56. http://dx.doi.org/10.1353/hpn.2018.0192.

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Hamed, NahlaAbdel Moneim, Nabil El Halawani, Dalia Nafea, MohamedAbd El Rahman et Ahmed Kasber. « Soluble HLA-G : A novel marker in acute myeloid leukemia patients ». Acta Medica International 4, n^o 1 (2017) : 51. http://dx.doi.org/10.5530/ami.2017.4.10.

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Gelmini, Georgia Fernanda, Cynthia Hernandes Costa, Fabiola da Silva Nardi, Pryscilla Fanini Wowk, Sibelle Botogosque Mattar, Alessandro Schuffner, Maria da Graça Bicalho et Valéria Maria Munhoz Sperandio Roxo. « Is HLA-E a possible genetic marker relevant for natural conception ? » American Journal of Reproductive Immunology 76, n^o 6 (7 octobre 2016) : 439–42. http://dx.doi.org/10.1111/aji.12587.

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Meuleman, Tess, Geert W. Haasnoot, Jan M. M. van Lith, Willem Verduijn, Kitty W. M. Bloemenkamp et Frans H. J. Claas. « Paternal HLA-C is a risk factor in unexplained recurrent miscarriage ». American Journal of Reproductive Immunology 79, n^o 2 (4 décembre 2017) : e12797. http://dx.doi.org/10.1111/aji.12797.

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Nardi, Fabiola da Silva, Renata Slowik, Tatiana Michelon, Luis Felipe dos Santos Manvailer, Bettina Wagner, Jorge Neumann, Peter Horn, Maria da Graça Bicalho et Vera Rebmann. « High Amounts of Total and Extracellular Vesicle-Derived Soluble HLA-G are Associated with HLA-G 14-bp Deletion Variant in Women with Embryo Implantation Failure ». American Journal of Reproductive Immunology 75, n^o 6 (9 mars 2016) : 661–71. http://dx.doi.org/10.1111/aji.12507.

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Lim, Agnes H. N., Sharon E. Nebuda, James A. Jung, Jaime M. Daniels, Andrew Bailey, Wayne Bresky, Li Bi et Avichal Mehra. « Optimizing the Assimilation of the GOES-16/-17 Atmospheric Motion Vectors in the Hurricane Weather Forecasting (HWRF) Model ». Remote Sensing 14, n^o 13 (26 juin 2022) : 3068. http://dx.doi.org/10.3390/rs14133068.

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Hourly and 15 min GOES-16 and -17 atmospheric motion vectors (AMVs) are evaluated using the 2020 version of the operational HWRF to assess their impact on tropical cyclone forecasting. The evaluation includes infrared (IR), visible (VIS), shortwave (SWIR), clear air, and cloud top water vapor (CAWV and CTWV) AMVs derived from the ABI imagery. Several changes are made to optimize the assimilation of these winds. The observational error profile is inflated to avoid overweighting of the AMVs. The range of allowable AMV wind speeds entering the assimilation system is increased to include larger wind speeds observed in tropical cyclones. Two data quality checks, commonly used for rejecting AMVs, namely QI and PCT1, have been removed. These changes resulted in a 20–40% increase in the number of AMVs assimilated. One additional change, specific to infrared AMVs, is narrowing the atmospheric layer where IR AMVs are rejected from 400–800 hPa to 400–600 hPa. The AMVs’ impact on forecast skill is assessed using storms from the North Atlantic and the Eastern Pacific, respectively. Overall, GOES-16 and -17 AMVs are beneficial for improving tropical cyclone forecasting. Positive analysis and forecast impact are obtained for track error, intensity error, minimum central pressure error, and storm size.

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