Articles de revues : « Hope's Windows »

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Madsen, David B., and James E. Kirkman. "Hunting Hoppers." American Antiquity 53, no. 3 (1988): 593–604. http://dx.doi.org/10.2307/281220.

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Lakeside Cave deposits spanning the last 5,000 years contain evidence of grasshopper (Melanoplus sanguinipes) use. Abundant ethnographic/ethnohistoric data suggest the widespread use of hoppers and other insects. Procurement strategies may be unique to the Great Salt Lake area. During the summer, salted and sun-dried hoppers are washed up on beaches and form windrows up to .2 m× 1.5 m× 15 km Hoppers produce over 3,010 kcal/ kg, and return rates average 272,649 kcal/hour. Digestible proportions have not been determined, but even at a return rate well below the experimental value, optimality models suggest hopper collection should be favored over all other collected resources.

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GREEN, CLIFFORD. "Dietrich Bonhoeffer's Letter to Mahatma Gandhi." Journal of Ecclesiastical History 72, no. 1 (2020): 113–21. http://dx.doi.org/10.1017/s0022046920000093.

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This first publication of the newly-found letter to Gandhi from Dietrich Bonhoeffer is a window into his thinking in the early 1930s, a time of personal formation and of resistance to National Socialism. Western Christianity needed ‘a Christian peace movement’, and Bonhoeffer wanted to learn from Gandhi's movement ‘the meaning of Christian life, of real community life, of truth and love in reality’. The letter includes Bonhoeffer's critique of Western culture and the Church in Europe and America, his hopes for a Church regenerated by the Sermon on the Mount, and his appreciation and critique of Karl Barth

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Puscasu, Ela-Andrada. "The Impact of Russia’s Invasion of Ukraine on the Capital Markets from the CEE Countries." Proceedings of the International Conference on Business Excellence 17, no. 1 (2023): 1791–806. http://dx.doi.org/10.2478/picbe-2023-0159.

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Abstract The price of stocks is a good indication of investors’ expectations for the evolution of capital markets, comprising their fears and hopes regarding future developments. The information regarding a disruptive event such as a military attack spreads rapidly across countries affecting investors’ perceptions and causing them to sell their stocks and target safer investments. The scientific literature on the topic is growing lately due to the ongoing Russo-Ukrainian war and its consequences. The research paper investigates the impact of Russia’s invasion of Ukraine on the capital markets from the Central and Eastern European region using the event study methodology. The paper studies the abnormal returns recorded by each capital market on the event day (February 24, 2022), as well as the cumulative abnormal returns for 6-day, 11-day and 16-day event windows following the attack. The findings show that most of the capital markets recorded sharp declines on the event-day, reaching a negative abnormal return event of 10% on February 24. For the longer event windows the negative impact persisted through cumulative abnormal returns recorded for most of the markets. The highest declines were recorded on the 6-day and 11-day event windows as all capital markets considered incorporating the bad news of the war outbreak and lost the initial hope of being a disinformation or a short-term military attack. Within 35 trading days following the invasion, 64% of the markets rebounded and returned to their pre-attack level. However, 4 capital markets recorded more than 200 trading days with a level lower than the one registered before the invasion. The paper contributes to literature extending the studies of capital markets’ behavior during military conflicts focusing on neighboring countries.

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Mei, Leyun, and Hongmei Ruan. "A Corpus-Based Study on Classical Poetry’s Translation of The Governance of China III from Perspective of Translation Ethics." International Journal of Languages, Literature and Linguistics 10, no. 2 (2024): 189–94. http://dx.doi.org/10.18178/ijlll.2024.10.2.510.

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The Governance of China III is a representative book to shape the national image and enhance national self-confidence. Its English translation is a window for foreign readers to understand China. In the process of translation, translation strategies and methods reflect translators’ choice of different ethical models. This paper takes the English translation of classical poetry in The Governance of China III as the main research object, takes Chesterman’s five ethics models as the theoretical basis, builds a corpus to explore the application of five ethical models in the process of translating classical poetry, and hopes to provide some views on the political publicity translation of classical poetry.

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Ostapenko, L. "The Biblical Code in the Novel «Windows on the World» by Frédéric Beigbeder." Literature and Culture of Polissya 106, no. 20f (2022): 63–75. http://dx.doi.org/10.31654/2520-6966-2022-20f-106-63-75.

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The article represents the interpretation of the novel "Windows on the World" by the modern French writer Frédéric Beigbeder from the point of view of the biblical code. The author of the article distinguishes two levels of the presence of biblical components: explicit and implicit. The author inventories the Old Testament and New Testament images and motifs marked in the work, and she determines their functionality. The author proves that it is the components of the biblical code that perform content-creating and form-creating functions in the novel. The biblical code defines the structure of the novel as parabolic and deepens its dystopian content, giving it an eschatological dominant. The author pays special attention to the transformation of the biblical story about the Tower of Babel in the novel. The author proves that the Old Testament motifs of creation and destruction, which are associated with the image of the Tower of Babel, characterize the consequences of economic and cultural globalization in the novel by Frédéric Beigbeder and acquire an apocalyptic dimension. The writer assigns a special role in the process of globalization to marketing as a means of promoting mass culture, which produces a profaned image of the world and brings humanity closer to its end. The author analyzes the novel’s intertextual connections, which are related to its biblical code. The image of the Catcher from the novel "The Catcher in the Rye" by J. David Salinger deepens the semantics of the biblical code in the novel "Windows on the World." The writer demonstrates that the messianism of the "broken generation" of America, which was represented by JD Salinger, later turned into "superheroism", and the path of spiritual ascent was profaned by the construction of skyscrapers. The author proves that with the help of the biblical code, the writer builds his own eschatological vision of the world, which deviates from the metanarratives of Christianity and globalism and takes away humanity’s last hopes. The apocalypse that Frédéric Beigbeder recreates in the novel "Windows on the World" provides redemption, but it does not guarantee salvation. His "Savior" reminds mankind only of death and it does not promise eternal life to anyone.

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Jacob, Priyanka Anne. "THE RELIC AND THE RUIN: EQUIVOCAL OBJECTS AND THE PRESENCE OF THE PAST INDANIEL DERONDA." Victorian Literature and Culture 44, no. 4 (2016): 855–74. http://dx.doi.org/10.1017/s1060150316000243.

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Early in George Eliot'sDaniel Deronda, Daniel's life is set on a decisive new path by his fleeting attraction to an object in a shop window. He is turning into a side street off Holburn Road when:his attention was caught by some fine old clasps in chased silver displayed in the window at his right hand. His first thought was that [his aunt] Lady Mallinger, who had a strictly Protestant taste for such Catholic spoils, might like to have these missal-clasps turned into a bracelet; then his eyes travelled over the other contents of the window, and he saw that the shop was that kind of pawnbroker's where the lead is given to jewellery, lace, and all equivocal objects introduced asbric-a-brac. A placard in one corner announced –Watches and Jewellery exchanged and repaired. (344; bk. 4, ch. 6)Daniel then moves across the street to avoid the shopkeeper, and it is only from this new vantage point that he notices the name “Ezra Cohen” above the window – the name he's been seeking while wandering Jewish neighborhoods in London in the hopes of reuniting his protégée Mirah with her family. He will return to the pawnshop later and become acquainted with the Cohens, eventually finding through them his mentor and Mirah's actual brother, Mordecai. Although some discussion of the silver clasps ensues, they are neither purchased nor used in the space of the novel. Still, this seemingly inconsequential trinket proves to have a long history, one that raises questions about the lingering remains of the past, the equivocality of the object, and the dispossessions that hauntDaniel Deronda.

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Abelman, Rachel Occhiogrosso, Bogang Wu, Laura M. Spring, Leif W. Ellisen, and Aditya Bardia. "Mechanisms of Resistance to Antibody–Drug Conjugates." Cancers 15, no. 4 (2023): 1278. http://dx.doi.org/10.3390/cancers15041278.

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Antibody–drug conjugates (ADCs), with antibodies targeted against specific antigens linked to cytotoxic payloads, offer the opportunity for a more specific delivery of chemotherapy and other bioactive payloads to minimize side effects. First approved in the setting of HER2+ breast cancer, more recent ADCs have been developed for triple-negative breast cancer (TNBC) and, most recently, hormone receptor-positive (HR+) breast cancer. While antibody–drug conjugates have compared favorably against traditional chemotherapy in some settings, patients eventually progress on these therapies and require a change in treatment. Mechanisms to explain the resistance to ADCs are highly sought after, in hopes of developing next-line treatment options and expanding the therapeutic windows of existing therapies. These resistance mechanisms are categorized as follows: change in antigen expression, change in ADC processing and resistance, and efflux of the ADC payload. This paper reviews the recently published literature on these mechanisms as well as potential options to overcome these barriers.

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Akil, Omar, Frank Dyka, Charlotte Calvet, et al. "Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model." Proceedings of the National Academy of Sciences 116, no. 10 (2019): 4496–501. http://dx.doi.org/10.1073/pnas.1817537116.

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Autosomal recessive genetic forms (DFNB) account for most cases of profound congenital deafness. Adeno-associated virus (AAV)-based gene therapy is a promising therapeutic option, but is limited by a potentially short therapeutic window and the constrained packaging capacity of the vector. We focus here on the otoferlin gene underlying DFNB9, one of the most frequent genetic forms of congenital deafness. We adopted a dual AAV approach using two different recombinant vectors, one containing the 5′ and the other the 3′ portions of otoferlin cDNA, which exceed the packaging capacity of the AAV when combined. A single delivery of the vector pair into the mature cochlea ofOtof−/−mutant mice reconstituted the otoferlin cDNA coding sequence through recombination of the 5′ and 3′ cDNAs, leading to the durable restoration of otoferlin expression in transduced cells and a reversal of the deafness phenotype, raising hopes for future gene therapy trials in DFNB9 patients.

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Wallis, Joe. "Conspiracy and The Policy Process: A Case Study of the New Zealand Experiment." Journal of Public Policy 17, no. 1 (1997): 1–29. http://dx.doi.org/10.1017/s0143814x0000341x.

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ABSTRACTThis paper advances the concept of a policy conspiracy – perpetrators strive together to steer the policy process in a direction which they believe to be worthwhile and possible. A policy conspiracy is conceived as an exclusive social network of policy participants who commit themselves to the advancement of a policy quest which embodies their shared hopes and who promote one another to positions of influence on the basis of the mutual trust they develop through regular interaction. The degree to which the network of technocrats, technopols and change agents who played a pivotal role in the implementation and consolidation of the ‘New Zealand experiment’ between 1984 and 1993 exhibit these characteristics is considered. By examining the way this policy conspiracy took advantage of a significant window of opportunity for reform, this paper seeks to make a contribution to the literature concerned with the conditions for radical policy reform.

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Loic, Erika. "The Once and Future Histories of the Book." Latin American and Latinx Visual Culture 4, no. 1 (2022): 9–26. http://dx.doi.org/10.1525/lavc.2022.4.1.9.

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Contemporary Latin American and Latinx artists who engage with pre-Hispanic and early colonial book histories have adapted the materials, formats, or iconographies of sixteenth- and seventeenth-century books and objects of knowledge transfer. Although the resulting artworks are as wildly varied as the idea of the book itself, they constitute forms of decolonial praxis in their desire to reclaim or reassign agency in historical narratives; uncover, criticize, or dismantle structures of inequity; or preserve, re-create, and cocreate knowledge. Artists’ remixes and renewals are not derivative or motivated by a simple desire to preserve the past. Some have reclaimed pre-Hispanic techniques to tell new stories, or they have reimagined the book altogether, abandoning its conventional structures and transmuting pre- and postconquest iconographies into murals, sculpture, film, or more conceptual/hybrid works. Contemporary artists have also looked to early colonial books as windows into Indigenous experiences of the conquest, amplifying those perspectives while relating them to recent sociopolitical realities and their hopes for the future. The artists discussed in this essay include Mariana Castillo Deball (Mexico), Sandy Rodriguez (United States), Carlos Colín (Mexico), Estefanía Peñafiel Loaiza (Ecuador), Falco (Ecuador), Andrés Pereira Paz (Bolivia), and Cecilia Vicuña (Chile).

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Petersen, Alan, Claire Tanner, and Megan Munsie. "Between hope and evidence: How community advisors demarcate the boundary between legitimate and illegitimate stem cell treatments." Health: An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine 19, no. 2 (2014): 188–206. http://dx.doi.org/10.1177/1363459314555240.

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Stem cell science provides an exemplary study of the ‘management of hope’. On the one hand, raising ‘hopes’ and expectations is a seen as a necessary aspect of securing investment in promising innovative research. On the other, such hyperbole risks raising hopes to a level that may lead people to undertake undue risks, which may ultimately undermine confidence in medical research. In this context, the ‘management of hope’ thus involves the negotiation of competing claims of truth about the value and safety of particular treatments and about the trustworthiness of providers. Using Gieryn’s concept of boundary-work, this article examines the means by which this work of ‘managing hope’ is undertaken. Drawing on data collected as part of our study that investigated the perspectives of those who are consulted by patients and their carers about stem cell treatments, we explore how these community advisors – both scientists and clinicians with a stake in stem cell research and representatives from patient advocacy groups – demarcate the boundary between legitimate and illegitimate treatments. In particular, we examine how these actors rhetorically use ‘evidence’ to achieve this demarcation. We argue that analysing accounts of how advisors respond to patient enquiries about stem cell treatments offers a window for examining the workings of the politics of hope within contemporary bioscience and biomedicine. In conclusion, we emphasize the need to re-conceptualize the boundary between science and non-science so as to allow a better appreciation of the realities of health care in the age of medical travel.

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Wulandari, Wulandari, and Rosa Afriliani. "PEMANFAATAN MOBILE COMMERCE GUNA MENINGKATKAN PENJUALAN UMKM NARESCRAFT DI DESA TULUNG AGUNG." Jurnal Signaling 10, no. 1 (2021): 18. http://dx.doi.org/10.56327/signaling.v10i1.1007.

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Narescraft UMKM is a business that produces various kinds of handicraft products made of talikur and acrylic. This UMKM is located in Tulung Agung Village, Kec. Gadingrejo, Kab. Pringsewu. This UMKM produces items such as bags made of talikur, decorative flowers from acrylic, tissue boxes and aqua baskets, and many others. This research discusses the use of m-commerce at Narecraft UMKM to increase product sales. One form of constraint experienced by Narescraft UMKM is product marketing that has not been widespread due to a lack of knowledge about current technological developments. One of the benefits of this research is to make it easier. consumers to get goods according to what they want easily. This research designs a website as a means of promotion or sale of products from UMKM so that products from UMKM can be widely known by the outside community. Researchers design a website using mobile software. a free application/software that can make the best free responsive website designs for Windows, Mac, and Android. Researchers use the implementation of m-commerce with websites on UMKM so that they can help reduce costs and can convey detailed information. This research hopes to help increase sales of these handicraft products.

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Mack, Beverly. "“This Will (Not) Be Handled by the Press:” Problems—and Their Solution—in Preparing Camera-Ready Copy for The Collected Works of Nana Asma'u, 1793–1864." History in Africa 25 (1998): 161–69. http://dx.doi.org/10.2307/3172186.

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In 1990 Jean Boyd and I began work on an edition of the works of Nana Asma'u. If not a trail of tears, finishing this proved at least to be an odyssey, taking two or three times as long as we had optimistically anticipated. In hopes of making it easier for others to be more realistic, we provide a brief account of this sojourn.Adam Jones, and especially, Knut Vikør, have provided extensive guidelines for scholars working with Arabic manuscripts and preparing them for camera ready copy. Most of the technology they describe is suited to use with Macintosh PCs, and for a long time it has been Macintosh users who have been best able to deal with Arabic script and Arabic diacriticals in the transliterated form. The comments offered here reflect experience with a PC using WP 5.2 in DOS beginning in 1990. At the time, the massive size of our collection—and the need to reproduce Arabic, Hausa, and Fulfulde in WP 5.2—meant that we faced a different set of problems than those considered by others in the field using Macintoshes. Without an upgrade to WP 6.1 Windows very late in the process, this project could not have been completed satisfactorily.

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Moutsis, Ioannis. "Turkish Cypriot identity after 1974: Turkish Cypriots, Turks of Cyprus or Cypriots?" Synthesis: an Anglophone Journal of Comparative Literary Studies, no. 10 (May 1, 2017): 116. http://dx.doi.org/10.12681/syn.16247.

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The hopes created by the unexpected triumph of Mustafa Akıncı in the Turkish Cypriot parliamentary elections in 2015 opened once again the debate about Turkish Cypriot identity. Despite the various works on the issue since the opening of the borders in 2003, the issue of identity in the Turkish Cypriot community still remains under-researched. The hope of the Turkish Cypriots for reunification and an end to political isolation was replaced by skepticism after the rejection of the 2004 Annan Plan by the Greek Cypriots in a national referendum. Nevertheless the election of Mustafa Akιncı with an overwhelming sixty percent proves that the Turkish Cypriots should not be considered as loyal to the AKP-controlled Turkish political order as perhaps they were once thought to be. This article will attempt to examine the various aspects of Turkish Cypriot identity, as this has been formed by the Cyprus issue, their fifty-year-long isolation and the hope for an end of the present status quo that will open a window to the outside world forty-one years after the 1974 war and eleven years after the Annan Plan referenda.

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Hulme Kozey, Emily. "ANOTHERPERI TECHNESLITERATURE: INQUIRIES ABOUT ONE'S CRAFT AT DODONA." Greece and Rome 65, no. 2 (2018): 205–17. http://dx.doi.org/10.1017/s0017383518000153.

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Elite, Athenian, male – all three adjectives usually apply to our sources on the ancient world, and the study of ancient ethics (including even so-called ‘popular morality’) is no different in this respect. There are, however, a few exceptional sources that provide a window into a more diverse population and their hopes, desires, values, and insecurities. In the following, I wish to highlight one of these – the corpus of oracularlamellaefrom Dodona – and demonstrate how this body of evidence can shed new light on an old question. Specifically, I will consider what we can learn abouttechne(art, craft, profession) from these tablets; but in addition I hope readers with an interest in ancient ethics will see how promising this source is for further study on other topics. As I will show, alongside the better knownperi technesliterature – a group of texts from the fifth and fourth centuriesbcethat discuss medicine and other crafts from a theoretical standpoint – there is a small corpus of texts from Dodona that uses this same phrase and discusses the crafts from a far more practical perspective. The object of this article will be to show how these two corpora are mutually enlightening.

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Wang, Ru-Guan, Pai-Yu Wu, Chang-Yuan Liu, Jia-Cheng Tan, Mei-Ling Chuang, and Chien-Cheng Chou. "Route Planning for Fire Rescue Operations in Long-Term Care Facilities Using Ontology and Building Information Models." Buildings 12, no. 7 (2022): 1060. http://dx.doi.org/10.3390/buildings12071060.

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As our society ages, more and more elderly or disabled people live in long-term care (LTC) facilities, which are vulnerable to fires and may result in heavy casualties. Because of the low mobility of LTC residents, firefighters often need to enter the facility to save people. In addition, due to LTC facility management needs, many doors or windows on the passages for a fire rescue operation may be blocked. Thus, firefighters have to employ forcible entry tools such as disk cutters for passing through, which may lengthen the rescue time if an incorrect route or tool is utilized. As new information technologies such as ontology and building information modeling (BIM) have matured, this research aims at proposing a BIM-based ontology model to help firefighters determine better rescue routes instead of using rules of thumb. Factors such as the path length, building components and materials encountered, and forcible entry tools carried are considered in the model. Real LTC fire investigation reports are used for the comparisons between the original routes and the ones generated by the proposed model, and seven experts joined the evaluation workshop to provide further insights. The experts agreed that using the proposed approach can lead to better fire rescue route planning. The proposed BIM-based ontology model could be extended to accommodate additional needs for hospital fire scenes, in the hopes of enhancing the efficiency and effectiveness of firefighters’ rescue operations in such important facilities.

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Anggara, Windu, and Muhammad Iqbal. "Telaah Maqashid Syariah Terhadap Eksistensi Program Bantuan Pangan Non Tunai (BPNT) Pemerintah dalam Mensejahterahkan Ekonomi Masyarakat." Jurnal Abdi Mas Adzkia 2, no. 1 (2021): 35. http://dx.doi.org/10.30829/adzkia.v2i1.9485.

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Abstract Program Bantuan Pangan Non Tunai (BPNT) Pemerintah or The Government's Non-Cash Food Assistance Program is one of the means and hopes that can help the poor in Indonesia, especially in Patumbak District, Deli Serdang Regency to meet the needs of life in reaching the economic welfare of the community. Allah has given a signal to assist others, both needy and poor. With the perspective of maqashid sharia, at least it can open a window and a way for the poor who receive the assistance program to be able to change behaviour in producing a healthier and smarter generation, wherein the long term with the provision of the Governments'’ Non-Cash Food Assistance Program it is hoped that it can break the intergenerational chain of poverty and make the community independent and wise and not just expecting a helping hand from the government.

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Daniels, John Spencer, Ibrahim Albakry, Ramat Oyebunmi Braimah, and Mohammed Ismail Samara. "Is the Routine Removal of Titanium Plates and Screws Following Miniplate Osteosynthesis of Maxillofacial Bone Fractures Justified? A Fifteen-Year Experience in a Maxillofacial Centre, Saudi Arabia." Craniomaxillofacial Trauma & Reconstruction Open 6 (January 2021): 247275122110652. http://dx.doi.org/10.1177/24727512211065268.

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Background Routine removal of titanium miniplates in the maxillofacial region is still controversial. This current study hopes to share our experience with the different reasons for maxillofacial plates and screws removal following miniplate osteosynthesis. Methods This was a retrospective study of plates and screws removal following Open Reduction and Internal Fixation (ORIF) of maxillofacial fractures at King Khalid Hospital, Kingdom of Saudi Arabia, from 2005-2019. Information collected includes demographics, etiology and pattern of maxillofacial fractures, treatment modalities as well as reasons for plates and screws removal. Data was stored and analyzed using IBM SPSS Statistics for windows Version 25 (Armonk, NY: IBM Corp). Results A total of 985 patients with maxillofacial bone fractures had ORIF during the study period out of which 149 had miniplates and screws removed, giving a prevalence rate of 15.1%. There were 141 (94.6%) males and 8 (5.4%) females, with a M:F of 17.6:1. Their ages ranged from 4-65 years with mean (SD) at 24.6 (12.2) years. The age group from 16-30 years had the most cases of plates removal with statistical significance ( P = .000). Young age (43 (28.8%)) constituted the majority of reasons responsible for plate removal. The angle of the mandible is the site with the largest number of plate removal with 34 (22.8%) cases followed by the parasymphyseal site with 21 (14.1%) cases. Conclusion With removal rate of 15.1%, this study concluded that there is no evidence to support routine removal of asymptomatic plates and screws in maxillofacial region.

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Bobkin, Nikolay. "President Biden and Iran: assessing the prospects for returning to the JCPOA." Russia and America in the 21st Century, no. 3 (2022): 0. http://dx.doi.org/10.18254/s207054760020708-5.

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The article analyzes the positions of the United States and Iran in the negotiations on the renewal of the Joint Comprehensive Plan of Action (JCPOA), assesses the most serious differences in the approaches of the parties, and suggests possible changes in the process of dialogue ongoing in Vienna with the participation of all countries that have signed a nuclear agreement with Tehran. Despite many controversial actions and statements coming from senior Iranian leaders, it seems that Tehran was ready for a quick return to the JCPOA, but Washington was unable to resume compliance with the terms of the original agreement. The scientific hypothesis of the author is that what is happening between Iran and the United States is a confrontation between two points of view. The United States ignores the norms of international law and tries to impose its policy in the interests of maintaining its hegemony in the world. Iran believes that the UN-approved JCPOA must be respected by all parties without exception. In the author&apos;s opinion, the Biden administration&apos;s hopes of reaching a better agreement, with amended provisions on Iran&apos;s regional policy and its missile programs, are currently unrealistic and that the window for continued dialogue will not be open for long. Domestic opposition to Biden&apos;s policies hinders JCPOA revival.

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Thompson, Riki. "Screwed up, but working on it." Narrative Inquiry 22, no. 1 (2012): 86–104. http://dx.doi.org/10.1075/ni.22.1.06tho.

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The turn to narrative as a form of therapy has become a common practice with individuals telling their stories in private and public forums in hopes of finding healing and recovery for a wide variety of mental health disorders. With the emergence of the internet and the proliferation of new media forms, narrative practices have evolved concurrently. An examination of the digitally mediated narratives I call e-stories, on mental health community websites can provide a window into how people use psychological concepts in narratives to do mental health work in everyday life (Edwards & Potter, 1992). This case study of the HealthyPlace online journal community shows how e-stories play a significant role in self-identity construction and ideological reproductive work in relation to mental illness and recovery. This research examines autobiographical introductions posted on twenty-eight journal homepages to explore how everyday people use psychotherapeutic coherence systems — lay versions of expert knowledge — to demonstrate expertise and authority while organizing experiences into a socially sharable narrative, characterizing self-identity in terms of illness and health simultaneously. These e-stories reveal the power of language to serve as a tool to negotiate community membership, reproduce ideologies about mental health and recovery, and employ narrative devices online to represent self-identities of people as “screwed up, but working on it.”

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Weydert, Zoe, Madhu Lal-Nag, Lesley Mathews-Greiner, et al. "A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells." SLAS DISCOVERY: Advancing the Science of Drug Discovery 25, no. 3 (2019): 265–76. http://dx.doi.org/10.1177/2472555219880194.

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Three-dimensional (3D) cell culture models are thought to mimic the physiological and pharmacological properties of tissues in vivo more accurately than two-dimensional cultures on plastic dishes. For the development of cancer therapies, 3D spheroid models are being created to reflect the complex histology and physiology of primary tumors with the hopes that drug responses will be more similar to and as predictive as those obtained in vivo. The effect of additional cell types in tumors, such as stromal cells, and the resulting heterotypic cell–cell crosstalk can be investigated in these heterotypic 3D cell cultures. Here, a high-throughput screening-compatible drug testing platform based on 3D multicellular spheroid models is described that enables the parallel assessment of toxicity on stromal cells and efficacy on cancer cells by drug candidates. These heterotypic microtissue tumor models incorporate NIH3T3 fibroblasts as stromal cells that are engineered with a reporter gene encoding secreted NanoLUC luciferase. By tracking the NanoLUC signal in the media over time, a time-related measurement of the cytotoxic effects of drugs on stromal cells over the cancer cells was possible, thus enabling the identification of a therapeutic window. An in vitro therapeutic index parameter is proposed to help distinguish and classify those compounds with broad cytotoxic effects versus those that are more selective at targeting cancer cells.

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Wang, He, Yangyong Sun, Jianhui Peng, et al. "An Analysis of Total Arch Re-Replacement After Proximal Aortic Surgery." Heart Surgery Forum 25, no. 4 (2022): E616—E620. http://dx.doi.org/10.1532/hsf.4663.

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Background: After proximal aortic surgery, total arch replacement (TAR) may again be needed because of recurrent dissection or aneurysm. This paper analyzed the relevant data of this technology with hopes of improving cognition and treatment. Methods: There were a total of 60 eligible cases of secondary TAR after proximal aortic surgery in our center from 2010 to 2020. The primary surgical procedures included aortic valve replacement (AVR), ascending aortic replacement, Bentall, hemi-arch replacement, and thoracic endovascular aortic repair (TEVAR). The data were analyzed using the IBM SPSS Statistics 23.0 for Windows™ and presented as the mean ± standard deviations and direct frequencies, as appropriate. Results: The interval between two operations was 44.8±53.6 months, 24 cases (40%) underwent emergency operation, the recurrence of type A dissection included 51 cases, accounting for 85% of the causes of total arch re-replacement. In the second surgical procedures, the ascending + TAR + stented elephant trunk (SET) implantation accounted for 75.0%. The overall surgical success rate was 98.3%. Postoperative respiratory complications were the most common, including infection, pneumothorax and hemothorax in 21 cases (35.6%). The second most common complication was acute kidney injury (AKI) in six cases (10.2%), and neurological complications took place in three cases (5.1%). The 30-day mortality rate was 15.3% and the 1-, 3- and 5-year survival rates were 96.0%, 84.0%, and 76.0%, respectively. Conclusions: The recurrence of dissection is the main cause of TAR after proximal aortic surgery, followed by aneurysm and the resurgical criteria for aneurysm needs to be unified. In addition to TAR, SET also is widely used. Despite high early mortality, its long-term prognosis is acceptable.

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Hamid, Sadek. "Young British Muslims." American Journal of Islam and Society 30, no. 4 (2013): 118–20. http://dx.doi.org/10.35632/ajis.v30i4.1092.

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Most popular and academic interest in the subject of British Muslim communities in recent years can be located within the context public debates around the visible presence of western Muslims and fears of radicalization and religious extremism. The 7/7 London bombings of 2005, which increased the attention of journalists, researchers, and government policymakers on Muslim young people, has resulted in numerous books, reports, and journal articles purporting to explain why some young British Muslims seem attracted to terrorism. The title under review joins a handful of similar publications that provide more nunanced observations in this field, notably, Philip Lewis’ Young, British, and Muslim(2007), Anshuman Mondal’s Young British Muslim Voices (2008), and Sughra Ahmed’s Seen and Not Heard: Voices of Young British Muslims (2009), all of which explore the lives, experiences, and views of young Muslims in Britain. This important subject area warrants deep research and rigorous analysis. Nahid Afrose Kabir’s extensive ethnographic fieldwork draws upon 216 interviews with young people aged between fifteen and thirty from five of Britain’s main cities with substantial Muslim communities. Structured around the themes of identity, religion, and culture, it also includes responses to questions of citizenship and loyalty, media bias, recent controversies around the niqab (face veil), and reactions to the Archbishop of Canterbury’s comments on implementing aspects of the Shari‘ah in the country. Overall, it makes a contribution to the nascent field of Muslim youth studies by offering windows into the hopes and aspirations of young British Muslims as well as presenting ...

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Yogi, Etika Desi. "HUBUNGAN PARITAS DENGAN DERAJAT LASERASI JALAN LAHIR DI POLINDES JETIS LOR KECAMATAN NAWANGAN KABUPATEN PACITAN." Jurnal Delima Harapan 6, no. 1 (2019): 48–53. http://dx.doi.org/10.31935/delima.v6i1.73.

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For women, the perineum is very important stretching and lubricating the perineum during labor can weaken the pelvic floor muscles in the vaginal wall, trauma to the perineum also causes discomfort and pain during sexual intercourse and an estimated 85% of maternal mothers experience birth canal lacerations (Kettle and Tohil 2008). One of the fears that are often felt by pregnant women, especially third timers, is fear of being torn and afraid of sewing. Especially for mothers who have experienced it, this can make their own trauma when facing the birth process later (USU, 2006). The purpose of this study was to determine the relationship of parity to the degree of laceration of the birth pathway in Jetis Lor Polindes, Nawangan District, Pacitan Regency. The design or design in this study is correlation analysis, with the "retrospective" approach. This study analyzed the relationship of parity with the degree of laceration of the birth path in Jetis Lor Polindes, Nawangan District, Pacitan Regency. In this study, the population was all mothers giving birth at Jetis Lor Polindes, Nawangan District, Pacitan Regency. The samples in this study were all mothers giving birth at Jetis Lor Polindes, Nawangan District, Pacitan Regency. In this study by looking at the last 1 year data. In this study the independent variable is parity. In this study the dependent variable is the degree of laceration of the birth canal. Based on the calculation results of SPSS 11.5 for Windows, it was found that there was no relationship between parity and laceration degrees in the Jetis Lor Polindes, Nawangan Subdistrict, Pacitan Regency, from the results of probability (sig. 2-tailed) 0.22 <0.05.The researcher hopes that the mother will seek information and increase knowledge about the labor process, so that with good knowledge will reduce lacerations on the birth canal

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Tracy, James. "Princely Auctoritas or the Freedom of Europe: Justus Lipsius on a Netherlands Political Dilemma." Journal of Early Modern History 11, no. 4-5 (2007): 303–29. http://dx.doi.org/10.1163/157006507782263380.

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AbstractLike not a few of his compatriots, Justus Lipsius changed his allegiance more than once during the long civil war between the Spanish crown and the Dutch rebels. What makes him unusual is that this noted classical scholar was also a voracious and critical consumer of reports about events of his own time and place; Lipsius' voluminous correspondence thus opens a rare window into what the Dutch Revot looked like to an anxious and well-informed citizen of the Low Countries. Unable to live under the tyranny of the duke of Alba, he accepted a post at the University of Leiden; from here he viewed the rebel provinces of the north as a bulwark against a Spanish hegemony that threatened to engulf Europe. Yet, as a devoted adherent of the monarchical principle of government, he found that he also could not live under a "polyarchy" of provicial parliaments, in which, as Lipsius saw things, wealthy burghers governed in their own interest. Hence he took a new position at the University of Louvain, in his native Brabant. It was not at first a fortunate choice, for just as Lipsius moved the military fortunes of the Dutch government changed for the better, while Philip II was distracted by plans to put a Spanish princess on the French throne. Only when Spain's ambitions in France were thwarted by the successes of Henry IV did Lipsius's hopes revive: in Albert and Isabella, 'natural' princes who intended to focus on the southern Netherlands, he seems to have found at last a government he could accept.

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Painter, Thomas M. "Rediscovering Sources of Nigerien History: The Dosso Archives." History in Africa 12 (1985): 375–78. http://dx.doi.org/10.2307/3171732.

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This is a report on provisional efforts to reorganize a regional archive in Dosso, Niger. The information is provided in hopes that it will be of some use to students of West African history, and will arouse the interest of archivists.While conducting research in the Dosso region of Niger during 1981 and 1982, I had occasion to work with historical materials in the Prefectural archives of the Department of Dosso. At the time of my arrival in Dosso, the archival documents were stored in more than twenty metal and wooden cabinets and files, and on open shelves. These were located inside a very large room without electric lights, illuminated dimly during the daylight hours by a single small window, permanently open and paneless, high on as eastward facing wall. The disorder of the cabinets inside the room was such at the beginning that it was impossible to penetrate more than a few feet. In some cabinets the contents were more or less uniform, but in most there was considerable disarray, said to date from the late 1970s when a national youth festival was held in Dosso. As a result, it was not uncommon to find mimeographed reports from the 1970s alongside registers of handwritten.entries dating from the early 1900s, and typescripts from the 1930s and 1940s. In others, voracious termites left for years to eat as they liked, had caused considerable destruction, consuming the documents, and in the case of wooden construction, the cabinets and shelves that contained them.

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Lakusta, Tetiana. "The Topos of Childhood in the Poetry of Moses Rosenkranz." Pitannâ lìteraturoznavstva, no. 100 (December 27, 2019): 42–57. http://dx.doi.org/10.31861/pytlit2019.100.042.

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The subject of this article is to study the literary space of childhood in the lyrical works of Moses Rosenkranz. The poems “Geburtspunkt” (“Birthplace”), “Meine Dörfer” (“My Villages”), “Auf der Weide” (“In the Pasture”), “Erinnerung” (“Memory”), “Nachts am Fenster” (“At Night by the Window”), “Der Bach” (“Stream”), “Die Liebe im Dorf” (“Village Love”), “Sonntag” (“Sunday”), “Tiefer Zug” (“Deep Mark”) from collection “Bukowina. Gedichte 1920–1997” have become the basis for the study of images and motifs traditionally associated with childhood – home, parents, garden, village, the theme of memory, motif of the lost paradise and ways of their literary actualization. The article attempts to determine the features of the topos of childhood in the lyrics of Moses Rosenkranz: the insecurity of the childhood from the destructive power of the adult world, the special importance of the theme of the lost paradise, which exposes the conflict of the adult and child worlds, the idyllic chronotope traditionally associated with the theme of childhood. In the course of this study, it has been found that Bukovinian images and motifs are key in the poetic work of Moses Rosenkranz. The land where he was born and spent his childhood and youth is portrayed by the author in his lyrical works with particular warmth and tenderness. Even being far from Bukovina, the author did not forget his country and imprinted his image in poems. The space of Rosenkranz's childhood is full of idyll and harmony, though he had been impressed by the brutality of the adult world in the childhood. Moses Rosenkranz's favorite character is a simple peasant with his traditions, misfortunes and hopes.

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Mohamed, Youssef, and Christopher L. Passaglia. "Simulation of gravity- and pump-driven perfusion techniques for measuring outflow facility of ex vivo and in vivo eyes." PLOS ONE 18, no. 11 (2023): e0294607. http://dx.doi.org/10.1371/journal.pone.0294607.

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Aqueous humor dynamics are commonly assessed by infusing fluid into the eye and measuring intraocular pressure (IOP). From the pressure-flow relationship, conventional outflow facility is estimated to study glaucomatous processes that lower facility or identify therapeutics that enhance facility in hopes of restoring healthy IOP levels. The relative merits and limitations of constant flow (CF), gravity-driven constant pressure (CPg), and pump-driven constant pressure (CPp) infusion techniques were explored via simulations of a lumped parameter viscoelastic model of the eye. Model parameter values were based on published perfusion system properties and outflow facility data from rodents. Step increases in pressure or flow were simulated without and with IOP noise recorded from enucleated eyes, anesthetized animals, and conscious animals. Steady-state response levels were determined using published window and ratio criteria. Model simulations show that all perfusion techniques estimate facility accurately and that ocular fluid dynamics set a hard limit on how fast measurements can be taken. This limit can be approached with CPg and CPp systems by increasing their gain but not with CF systems, which invariably take longest to settle. Facility experiment duration is further lengthened by inclusion of IOP noise, and data filtering is needed for steady-state detection with in vivo noise. The ratio criterion was particularly affected because noise in the flow data is amplified by the higher gain of CPg and CPp systems. A recursive regression method is introduced, which can ignore large transient IOP fluctuations that interfere with steady-state detection by fitting incoming data to the viscoelastic eye model. The fitting method greatly speeds up data collection without loss of accuracy, which could enable outflow facility measurements in conscious animals. The model may be generalized to study response dynamics to fluid infusion in other viscoelastic compartments of the body and model insights extended to optimize experiment design.

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Mahany, Barbara. "They've Got Pluck: CHA Youth Orchestra a Survival Kit for Kids in Public Housing." American String Teacher 41, no. 4 (1991): 57–59. http://dx.doi.org/10.1177/000313139104100433.

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EDITORIAL: Sweet Notes in the Projects The notion of letting children in Chicago Housing Authority developments take violins, cellos and string basses home to practice music composed a few centuries before the birth of Michael Jackson or Kool Moe Dee may seem bizarre to some, particularly those who have the benighted belief that nothing good can come out of “the projects.” It is a novel idea but, as Chicago has seen with CHA night basketball, the novel often sounds like nonsense but works quite nicely. The good that can be found in the quarter-million children who call CHA developments home is well represented in the 26 chosen so far for the Music Cultivation Program for CHA Youth. They range from kinder-garteners to 9th graders and were selected in July from four developments by teachers from the not-for-profit Merit Music Program. Officials of CHA and the 11-year-old Merit Music Program hope the Music Cultivation Program eventually will become a full symphony orchestra with bass, winds, percussion and strings. But for now, the children's parents must endure, like other good parents everywhere, the bittersweet joy and agony of hearing young hands become familiar with bows and strings. It may comfort them to know that the CHA's classical music pioneers are engaging in an experience that will help give structure and meaning to their lives no less than it does for children who live anywhere else. Whether or not they achieve their dreams of performing in Orchestra Hall someday—and who is to say some won't?—the lessons of form, grace, teamwork and discipline will serve them well, no matter what fields they pursue later in their lives. With determination on their part and support from others, the young musicians will find their horizons broadened and their self-esteem improved. And everyone else should have their hopes and dreams for the next generation boosted a little with the knowledge that, behind the torn window screens and graffiti-covered walls of public housing, some budding young talents are making beautiful music together.

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McManners, J. "Voltaire and the Monks." Studies in Church History 22 (1985): 319–42. http://dx.doi.org/10.1017/s0424208400008044.

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‘You can never cross the Pont Neuf without seeing a monk, a white horse and a whore’, ran the proverb – which was hard luck on the two ladies who stood there and saw the first two but could not find the third: ‘Pour la catin, vous et moi nous n’en sommes pas en peines’. Members of the religious Orders in their costumes of black, white, brown and grey were a feature of the scene in the streets of every town, and everyone had a monk or nun among their relatives. Voltaire’s sardonic examples of the characteristic features of the civilisation of his day included them: ‘man will always be what he is now; this does not mean to say, however, that there will always be fine cities, cannons firing a shot of 24 lbs weight, comic operas and convents of nuns’. Routine gossip slipped naturally into analogies drawn from the cloister – she is as fat as a monk; they were like children at a window crying out when they first see a Capucin friar; you are like a novice who climbs the walls looking for a lover, while the nuns in the chapel pray for her. Voltaire uses monastic titles in jocular descriptions of himself and his friends. He is the ‘old hermit’, the ‘lay brother’, the ‘solitary’, ‘brother Voltaire, dead to the world and in love with his cell and his convent’, and once, when his play Octave et le jeune Pompée was a flop, he decided to be, for a while, ‘the little ex-Jesuit’, ‘le petit défroqué’. He hopes ‘brother’ Helvétius will be elected to the Academy: ‘these are the most ardent prayers of the monk Voltairius, who from his lonely cell unites himself in spirit with his brethren’. The badinage of monastic seclusion hinted at protest at his long exile from Paris; it also served to mask the social distinctions, which, in spite of familiarity and, even, friendship, were never forgotten between the court grandees and the intellectuals. It was easier for Choiseul to write to him as ‘mon cher solitaire’, just as Voltaire avoided routine sycophancy by writing, with exaggerated deference, to Richelieu as ‘mon héros’.

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Deckmyn, Hans, Simon F. De Meyer, and Karen Vanhoorelbeke. "Drug Inhibition of GPIb." Blood 114, no. 22 (2009): SCI—38—SCI—38. http://dx.doi.org/10.1182/blood.v114.22.sci-38.sci-38.

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Abstract Abstract SCI-38 The platelet-specific glycoprotein (GP)Ib, member of the GPIb/IX/V complex, is the main receptor for von Willebrand Factor (VWF), but also for a growing list of other ligands such as thrombin, coagulation factor XI and XII, Mac-1 and P-selectin. For VWF and GPIb to interact, VWF needs to undergo a conformational change. In the circulation, this is induced by shear forces that stretch VWF, especially when bound onto collagen at vascular lesions. As the contribution of VWF to platelet adhesion becomes more important with increasing shear forces, the idea emerged that inhibition of the GPIb-VWF interaction could actually result in an antithrombotic effect targeted to high shear arterioles or stenosed arteries, leaving hemostasis virtually unaffected in vessel beds with slower circulation. And in the mean time, a growing amount of evidence suggests that this could lead to a lower bleeding risk than what is seen with currently available antithrombotic agents. Several compounds have been tested in the past such as fragments of VWF, snake venoms and antibodies. We developed an anti-human GPIb monoclonal antibody, 6B4, that competes directly for the binding site of VWF. The humanized 6B4 Fab-fragment effectively prevented repetitive occlusions of the damaged and stenosed femoral artery in a baboon thrombosis model. Interestingly, only little prolongation of the template bleeding time and minimal increase in blood loss from a standardized incision was observed. This apparent larger therapeutic window of GPIb inhibitors could be particularly useful in ischemic stroke, where the utility of current platelet inhibitors and anticoagulants is significantly counterbalanced by the risk of intracerebral bleeding complications. Recent promising results in a mouse model of cerebral ischemia/reperfusion indeed show a significantly less severe stroke outcome using a GPIb-inhibitor, either administered before or, importantly, after cerebral artery occlusion. No increase in intracerebral hemorrhages was detected, in contrast to what is seen with e.g. GPIIb/IIIa inhibition. Finally, as antibodies may be useful for acute treatments but not for chronic applications, the identification of a GPIb-inhibiting nonamer peptide raises hopes towards development of orally available small molecule inhibitors. Disclosures No relevant conflicts of interest to declare.

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Mohamed Daud, Mohamed Ashraf. "Hypospadias Repair: Outcome and Objective Evaluation with Hypospadias Objective Scoring Evaluation (HOSE), Hypospadias Objective Penile Evaluation (HOPE) and Pediatric Penile Perception Score (PPPS) from Parents Perspective and Preference in COVID-19 Era." Andrology and Genital Surgery 25, no. 1 (2024): 65–72. http://dx.doi.org/10.62968/2070-9781-2024-25-1-65-72.

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Introduction. Hypospadias is a common congenital abnormality. It may also be associated with other urogenital tract abnormalities. Literature has described more than 300 techniques being used. An objective evaluation is useful for attending doctor and parents to ensure both understands detection of complication and to assess post operative satisfaction from both sides are similar. Thus study sought to assess the outcome of hypospadias repair with objective scoring evaluation from parents’ perspective during COVID-19 era. Methods. This was a retrospective study of all patient post-hypospadias repair in Urology Unit, Hospital Universiti Sains Malaysia from January 2020 to December 2022 during the Covid-19 period. All patient medical records were reviewed. Data analyzed for demographic, surgical treatment, complications, and objective evaluation with HOSE, HOPE and PPPS questionnaire and parents preferred questionnaire to be used using Microsoft Excel for Windows 2003 and qualitative variables were presented as frequencies and simple percentages. Result. Hypospadias A total of 21 pediatric patients operated. The mean age during surgery was 7.2 years old. Distribution of glanular 6 patients, distal 3 patients and majority are proximal hypospadias with 12 patients (57.2%). Proximal hypospadias, 6 proximal penile and 6 penoscrotal. Single stage repair 18 patients and 2 patients had scrotoplasty performed and 3 patients had two stage repairs. Majority of single stage surgery performed was TIP and two stage repairs done with Bracka’s technique. Overall mean follow-up time 16.78 month. Three patients had UCF with 14.3%. Questionnaire with HOSE showed mean score 14.38. The HOPE questionnaire showed mean score of 54.71 and PPPS mean score was 10.2. Majority of parents preferred to use HOPE with 66.7% as compared to HOSE 14.3% and PPPS 19%. Discussion. This study has a small sample size possible due to very low rate for hypospadias in Malaysia and Covid-19 pandemic. Due to the pandemic, European Association of Urology recommended for repair before 18 months. However, if done after 2 years old showed significant predictor for complications. Validated questionnaires are useful and comparable to assess objectively both functional and patient satisfaction. However, HOPE might overestimate quality of cosmetic outcome compared with PPPS. Despite many available evaluation scoring systems were compared, reports show similar conclusions with none being more superior. Conclusion. Hypospadias requires complex surgery and complications are expected but should be within acceptable standards. In COVID-19 era, hypospadias repair had to be delayed and causes negative impact to patients. Despite many various techniques available, surgeons experience and technique preference are very important. There is no evaluation score more superior than another. It has its advantages and disadvantages. Parents satisfaction and functional outcome after repair should be routinely done for objective assessment.

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Yu, Jingyi, Yuanhang Zhang, Yaling Zhao, and Jiaying Zeng. "A probe into the Visual elements in female illustrations from the Perspective of Feminism." Highlights in Art and Design 2, no. 2 (2023): 83–88. http://dx.doi.org/10.54097/hiaad.v2i2.7031.

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With the rise of the feminist movement in the 1970s, the concept of feminism gradually entered the public's field of vision. Its theory revolves around with the development of society, the wave of feminism continues to deepen and affect all aspects of human life. The improvement of productivity and the change of production relations urge women to re-recognize themselves, and the improvement of productivity and the change of production relations urge women to re-recognize themselves, and women's self-worth and social status are more and more affirmed. The female image, as one of the common subjects in the history of eastern and western illustration, has rich forms of expression, thus reflecting multiple connotations, and analyzing the visual elements in female illustrations from the perspective of feminism. it provides a new perspective for illustration analysis, and can deeply understand the author's creative ideas through the selection and performance of picture elements. The author starts with feminist painting art, through the analysis of representative paintings including female images in Chinese and western art history. The author starts with feminist painting art, through the analysis of representative paintings including female images in Chinese and western art history, combined with feminist thoughts to analyze the implication behind image expression, and then from feminist painting to feminist illustration research As feminism goes deep into the public's As feminism goes deep into the public's field of vision, feminist illustration expression is endowed with more forms and meaning of the times, and it is always intended to show the viewer a At the same time, illustration, as a widely used form of artistic expression, can provide an effective perspective for feminist expression as a woman. At the same time, illustration, as a widely used form of artistic expression, can provide an effective perspective for feminist expression as a suitable medium, so as to provide a window for the public to understand feminism. The research and thinking of this paper is devoted to excavating the unique and diverse female beauty in different female paintings and illustrations. and hopes to appeal to the viewer to have more tolerance and appreciation of the current feminist art, in the present when many female artists are open up the artistic road in the future with practice.

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Moh, Youngdawng, and Changyoul Lee. "A Study on the Major Legal Issues of Marine Genetic Resources: Focusing on the 5-1 UN BBNJ Intergovernmental Conference Discussions." Korea International Law Review 64 (February 28, 2023): 115–45. http://dx.doi.org/10.25197/kilr.2023.64.115.

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The 5-1 UN BBNJ Intergovernmental Conference (‘IGC’) was adjourned against international community’s huge expectation for reaching consensus on the BBNJ agreement in 2022. However, the 5-1 IGC has been considered the IGC which substantially narrowed down the divergence between Parties. Against this backdrop, there are high hopes for adopting UN BBNJ in the coming IGC 5-2 . However, there are still the unsolved issues which require significant amount of discussions. Out of many issues, there are two major legal issues which the IGC 5-2 should resolve in the area of Marine Genetic Resources(‘MGR’). Since the beginning of the BBNJ agreement negotiation, the legal status of MGR has divided the delegations into two groups. One is those who are proponents for common heritage of mankind. This group believes the principle of common heritage of mankind applies to MGR. The other is those who are against this. There have been no consensus at all so far. Without any creative ideas to resolve the divergence between two, there would be a very small window to see the adoption of the UN BBNJ agreement. Even if the IGC 5-2 succeeds in the legal status of MGR, we still have the digital sequence information issue. At issue is whether digital sequence information falls under the definition of MGR. Considering the same discussions in Convention on Biological Diversity Conference of Parties(‘CBD COP’), there is very slim chance to arrive in consensus on this issue, too. The best scenario would be the case where all the legal issues are cleared and Parties reach consensus. However, this scenario seems very unlikely to be realized at the IGC 5-2. Considering the difficulties ahead, the IGC 5 should carefully look into the approach taken at the CBD COP 15 for successful adoption of Kunming-Montreal Global Biodiversity. The lessons learned the IGC 5-2 should take are the effective conference management and targeted consensus strategy. The CBD COP 15 managed conference effectively by forming Plenary-Working Group-Contact Group-Friends of the Chair structures. With this structure, the CBD COP could filer out the agenda and focus its time and resources on hard issues. In addition, the CBD COP15 draw consensus only where it is likely to reach. This targeted approach produced the result that the CBD COP 15 left many issues unsolved till the COP 16. However, the CBD COP 15 achieved what the CBD COP 15 had to on time. Applying the lessons learned at CBD COP 15, the IGC 5-2 should enhance the small group which was introduce for the first time at the IGC 5-1 for consensus between Parties who have opposing views on one issue. There has been not enough time for narrowing divergent views between Parties during the whole IGCs. What the IGC 5-2 might try next is to explicitly agree not to agree. By creating provisions which state Parties do not agree in the issues such as the legal status of MGR and the digital sequence information, Parties could clean the brackets and produce a clean text. When debates seem endless, we should move toward a new direction instead of circling around.

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Pabani, Aliyah, and Justin F. Gainor. "Facts and Hopes: Immunocytokines for Cancer Immunotherapy." Clinical Cancer Research, May 25, 2023. http://dx.doi.org/10.1158/1078-0432.ccr-22-1837.

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Abstract The clinical development of cytokines as cancer therapeutics has been limited due to significant toxicities generally observed with systemic administration. This narrow therapeutic window, together with relatively modest efficacy, have made natural cytokines unattractive drug candidates. Immunocytokines represent a class of next generation cytokines designed to overcome the challenges associated with traditional cytokines. These agents seek to improve the therapeutic index of cytokines by using antibodies as vehicles for the targeted delivery of immunomodulatory agents within the local tumor microenvironment. Various molecular formats and cytokine payloads have been studied. In this review, we provide an overview of the rationale, preclinical support, and current clinical development strategies for immunocytokines.

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Stella, Massimo. "Social discourse and reopening after COVID-19." First Monday, October 12, 2020. http://dx.doi.org/10.5210/fm.v25i11.10881.

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Although the COVID-19 pandemic has not been quenched yet, many countries lifted nationwide lockdowns to restart their economies, with citizens discussing the facets of reopening over social media. Investigating these online messages can open a window into people’s minds, unveiling their overall perceptions, their fears and hopes about the reopening. This window is opened and explored here for Italy, the first European country to adopt and release lockdown, by extracting key ideas and emotions over time from 400k Italian tweets about #fase2 — the reopening. Cognitive networks highlighted dynamical patterns of positive emotional contagion and inequality denounce invisible to sentiment analysis, in addition to a behavioural tendency for users to retweet either joyous or fearful content. While trust, sadness and anger fluctuated around quarantine-related concepts over time, Italians perceived politics and the government with a polarised emotional perception, strongly dominated by trust but occasionally featuring also anger and fear.

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Huang, Quincy F., Floraidh Rolf, Lauren A. Booker, Taleah Moore, and Sandra C. Thompson. "A qualitative study of how COVID-19 impacts on Australians’ hopes and dreams." BMC Public Health 22, no. 1 (2022). http://dx.doi.org/10.1186/s12889-022-12746-4.

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Abstract Background Although beginning in 2019, it was early in 2020 that the global community began to comprehend the significant impact that a pandemic of a new coronavirus might have on their own lives. This study was undertaken 6–9 months after significant public health restrictions were introduced within Australia and examined the impact of the COVID-19 on individuals’ hopes and dreams for their future. Methods Community members who responded to a survey about COVID-19 were invited to participate in follow up interviews if they reported living with a chronic condition. Participants across Australia who consented were interviewed between August and December in 2020 over telephone or videoconferencing. A specific question was included regarding the impact of COVID-19 on their hopes and dreams for the future. Rapid identification of themes with an audio recordings technique was used to generate themes from the data. Results The 90 participants were predominantly female (77%) and ranged in age from 20 to 81 years with a mean age of 50 years and lived in several Australian states. Following immersive analysis of interviews, the identified common themes impacting people’s hopes and dreams revealed: concerns for their own and others’ job stability and future work; the impact on travel both for holidays, business and reconnecting with family; reassessing of personal and social values; and the intergenerational impact of such a profound pandemic, with concern for younger people particularly prominent in those concerns. Participants reflected on their loss of future dreams, with possibilities they had planned and worked towards not possible in the short term. Conclusions The responses provide a window into how people view their future goals and aspirations during a time of global and local instability and highlights the potential future impacts of the COVID-19 pandemic.

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Herbst, Pauline. "Light, hope and COVID-19 in Aotearoa New Zealand." Sites: a journal of social anthropology and cultural studies 18, no. 2 (2022). http://dx.doi.org/10.11157/sites-id502.

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Photoessays bridge the borders between the text and the image, much as light and shadow combined transform a flat picture into a three-dimensional object. In this photo essay I trace the invisible borders tracked in daily sanctioned walks. This forms a truncated ethnographic journey into the suburban environment during a global pandemic, one hour a day. Belonging, home, care and nation in Aotearoa New Zealand are compressed in both space and time; less than a year; less than two square kilometres, a single suburb, one neighbourhood straddling three ‘zones’. Teddy bears stuffed in windows, painted stones laid in forests, and messages to essential workers reveal values and hoped for outcomes embodied in concrete, plastered cladding and trees. The environment becomes an artistic landscape, a canvas to express wishes, hopes and dreams of who we are and hope to be, during times when borders and borderlands, both bodily and institutional, are unmade and remade.

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Samboro, Drs Joko. "ANALISIS TINGKAT KEPUASAN PELANGGAN JASA INTERNET." IQTISHODUNA 3, no. 1 (2011). http://dx.doi.org/10.18860/iq.v3i1.241.

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This research analisys to find out the degree of customers’ satisfaction and to give informations to the management to direct customers’ need in order to achieve customers’ satisfactioan. To collect the data,the purposive sampling is applied in this research 90 guestionaires are distributed togo respondents and then they are analyzed by using the window of satisfaction on the cartecius diagram The result of the research indicates that mostof the cuatomers are not satisfied, the degree of their satisfactions is less than 100%. Further, some service items available in the firm are stiil low. The researcher hopes the result of this research is able to give the information to the firm’s leader in finding out the effective strategy in geeting more customers.

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Schneider, Christian. "Crusoe’s Broken Window: A tribute to Frédéric Bastiat." REVISTA PROCESOS DE MERCADO, April 27, 2017, 259–88. http://dx.doi.org/10.52195/pm.v14i1.93.

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Frédéric Bastiat was a great economist1 and writer, but most of all, he deserves everlasting fame as an educator. His 1850 essay «The Broken Window»2 teaches an unforgettable lesson. Unforgettable, on the one hand, because it is humiliating: humiliating to realize that one had not grasped an idea so simple yet so crucial for a basic understanding of economics. Unforgettable, on the other hand, be-cause once we have learned to «turn the mind’s eye to those hid-den consequences of human actions, which the bodily eye does not see» (Bastiat [1850] 2011a, 43), an intriguing journey of discovery begins. It has rightly been called «the one lesson»3 to which all economics can be reduced: to think through not only the visible and immediate consequences of human action and interaction, but also the unseen effects: those which are not yet seen, and those which will never be seen because they would follow only from an alternative course of action.4 Another sign of Bastiat’s excellence is that he was the first econ-omist to make extensive use of thought experiments with one or a few actors only, named, and sometimes ridiculed as, «Robinson Crusoe economics». In the imaginary laboratory of the desert is-land, we are free to set arbitrary conditions. In particular, we can construct the simplest version of any problem, where the essential features stand out most clearly. Simple scenarios, as Henry Hazlitt ([1946] 2008, 91) notes, «are ridiculed most by those who most need them, who fail to understand the particular principle illustrated even in this simple form, or who lose track of that principle com-pletely when they come to examine the bewildering complications of a great modern economic society». These complications can be mastered best by extending the analysis step by step from one ac-tor to a higher number, until real-world complexity is sufficiently approximated.5 When Bastiat was writing his last work That Which is Seen, and That Which is Not Seen, he was suffering from a terminal illness closing in on him. We can only speculate what form it might have taken and how much more he could have achieved, had he been granted more time. But what is obvious in the work he did is the importance of Crusoe scenarios and of that which remains unseen. The thought experiments presented in what follows merely com-bine these two ideas. Thus, this essay is deeply inspired by Basti-at’s way of thinking, and hopes to do honor to his inspiration.

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Tjørnhøj-Thomsen, Tine. "HJEM UDEN BØRN." Tidsskriftet Antropologi, no. 59/60 (December 1, 2009). http://dx.doi.org/10.7146/ta.v0i59/60.106838.

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This article explores how childless men and women in Denmark connect their longings for children and their purchase of a house with notions of home and kinship. It investigates thereby how their stories about hopes and longings for children stage and confi gure relationships between materiality and sociality. I draw primarily upon an ethnographic study of interfi le men and women in Denmark in the late nineties and their encounter with procreative technologies. The fi eldwork was centred on three local groups of the National Association for Involuntary Childless. Taking part in their meetings and social gatherings over a period of two years gave me an opportunity to obtain insights in how infertility affected and challenged their lives and plans, and it opened a window to a multi-faceted understanding of kinship in Denmark. This article thus focuses on the material dimensions of kinship and relatedness from a childless perspective. The childless people are in a particular empirical position because what they think and say about children and family life exists primarily as hopes, longings and future projections. The aspirations for children nevertheless contain things and materiality and they epitomize how physicality, locality, dwelling, things and consumer goods are part and parcel of kinship thinking. Keywords: Kinship, involuntary childlessness, things, house/home.

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Wu, Min-Hao, Ting-Cheng Chang, and Yi Li-Min. "Digital Forensics Security Analysis on iOS Devices." Journal of Web Engineering, June 9, 2021. http://dx.doi.org/10.13052/jwe1540-9589.20310.

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With the rapid development of the Internet era, cell phones play an essential and indispensable role in nowadays life. Smartphones have profoundly influenced our social relationships and our daily lives. Generally speaking, the most common tools we hear about in our daily lives are QQ, WeChat, and other Internet communication services that allow users to send text messages, pictures, and documents, providing a more convenient and faster medium for people to communicate and chat. The popularity and convenience of mobile technology have changed people’s habits of communication. People no longer need to rely on computers to communicate, and computers cannot communicate anytime and anywhere. In the kernel of Linux and Windows, as long as the Message Hooker will install, it can monitor the messages of other programs, including WeChat and QQ, in this research. We can provide relevant law enforcement officers with effective evidence collection so that criminals will not be able to hide. The suspects often delete their WeChat or QQ records after committing the crime. It impossible for our law enforcement agencies to obtain evidence directly from the cell phone and the crime facts. Our research hopes to use some technology to help law enforcement units effectively obtain strong evidence in the iPhone not to hide the crime facts.

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Chen, M. J., P. E. Yang, Y. C. Yi, et al. "P-517 The effects of various female infertility factors on endometrial receptivity." Human Reproduction 39, Supplement_1 (2024). http://dx.doi.org/10.1093/humrep/deae108.857.

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Abstract Study question Is there a correlation between different female infertility factors and displaced window of implantation? Summary answer Patients with decreased ovarian reserve and endometriosis have higher risk in experiencing displaced window of implantation. What is known already Numerous studies substantiate that infertility stems from various etiology, including ovulatory dysfunction, male factors, tubal disease, endometriosis, uterine factors...etc. MicroRNAs (miRNAs) play a crucial role in initiating these infertility-related disorders and influencing biological processes like gametogenesis, embryogenesis, ovarian, uterine or endometrial condition. Notably, miRNAs regulate endometrial receptivity, suggesting optimal embryo transfer timing during IVF treatment by identifying the window of implantation (WOI). In recognition of this significant function, MIRA, a molecular testing solution that predicts endometrial receptivity for patients undergoing frozen embryo transfer (FET) by targeting miRNA biomarkers, was developed in hopes of bolstering success rate for personalized embryo transfer. Study design, size, duration This study aims to identify if there is a correlation seen between female infertility factors and the WOI. We enrolled a total of 96 patients who demonstrated successful pregnancy outcomes following personalized embryo transfer. The patients’ personalized embryo transfer timing recommendations were assessed based on their miRNA expression profiles using MIRA. Concurrently, the participants’ underlining infertility diseases were classified according to diagnoses guidelines provided by Taiwan’s Ministry of Health and Welfare. Participants/materials, setting, methods Six categories of female infertility diseases were included: decreased ovarian reserve, tubal, endometriosis, uterine abnormalities (excluding myoma and adenomyosis), polycystic ovary syndrome (PCOS), and myoma factors. Infertile factors such as unexplained, aneuploid oocyte (PGT), male factors, and adenomyosis were excluded due to limited sample size. Statistical analysis of endometrial stages and disease categories involved calculating percentage of the window of implantation (WOI) versus displaced WOI (either pre- or post-receptive) within the six types of diseases. Main results and the role of chance Our result showed that overall, 64.58% of 96 patients have a receptive window of implantation. Compared to this baseline, polycystic ovary syndrome (66.67%) does not elevate the risk of displaced endometrial stages. However, patients with decreased ovarian reserve and endometriosis are more likely to display displaced window of implantation, with average rates of 57.14% and 55.56% WOI respectively. Notably, patients with uterine abnormalities (84.62%) and myoma (87.5%) factors exhibit a lower likelihood of having a displaced WOI. The WOI percentage caused by tubal factors is slightly lower at 76.19%. In conclusion, these preliminary findings establishes that categories of female infertility diseases have discernible effects on patients’ WOI. As patients with certain infertility factors, such as decreased ovarian reserve and endometriosis, demonstrated a greater risk in experiencing displaced WOI, patients that fall under these categories could further benefit from utilizing endometrial receptivity testing to determine the optimal timing for their embryo transfer to potentially improve their reproductive outcomes and facilitate shared decision-making (SDM) in patient’s embryo transfer process. Limitations, reasons for caution While this result offers a preliminary overview for the correlation between endometrial stages and female infertility diseases, we cannot confirm whether these conclusions reached statistical significance due to the limitation of data. Wider implications of the findings Further investigation into the specific reasons for the discernable WOI patterns in different diseases is warranted in larger sample sizes to offer more personalized and robust clinical information supporting IVF treatments. Trial registration number ’not applicable’

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Hooper, Destiny, Tariq Nisar, Meryim Poursheykhi, et al. "Abstract P499: The Effect of Small Vessel Disease Burden on Core/Penumbra Mismatch and Outcomes in Extended Window Thrombectomy." Stroke 52, Suppl_1 (2021). http://dx.doi.org/10.1161/str.52.suppl_1.p499.

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Objective: Recent studies have shown the benefit of revascularization in select patients with extended window large vessel occlusion (EWLVO). We sought to assess the effect of cerebral small vessel disease (CSVD) burden on eligibility for intervention with mechanical thrombectomy (MT) and functional outcomes in patients with EWLVO. Methods: We conducted a retrospective single-center study of 135 patients with anterior circulation LVO who presented in the extended time window, 6 to 24 hours from LKW, between August 2018 and March 2020. All patients underwent perfusion imaging at initial presentation and those with target ischemic core to penumbra mismatch profiles, as defined by DAWN/DEFUSE3 criteria, were treated with MT. Included patients were evaluated for CSVD burden using T2-FLAIR MRI. The Fazekas scale (0-3) was used to quantify the amount of white matter T2 hyperintense lesions in both the periventricular (PVWM) and deep white matter (DWM). Patients’ functional outcomes were assessed at 90 days using the mRS. Multivariate ordinal logistic regression models were used and adjusted for age, gender, thrombus location and LKW to perfusion imaging time. Patient information was collected from the Houston Methodist Hospital Outcomes Based Prospective Endpoints in Stroke (HOPES) registry. Results: Of the 135 patients, 111 met imaging inclusion criteria for revascularization with MT for EWLVO. MT was deferred in 44 of these patients due to other clinical exclusions or patient refusal. Patients ineligible for MT were approximately 13 times more likely to have a higher PVWM Fazekas grade (OR =13.53, 95% CI. [2.94 - 62.39], p=0.001) and 17 times more likely to have a higher DWM Fazekas grade (OR =17.54, 95% CI. [4.20 - 73.17], p<0.001), when compared to patients who were eligible for MT. Patients who did not meet criteria for MT were nearly 7 times more likely to have poor functional outcomes at 90 days (OR =6.85, 95% CI. [2.09 - 22.44], p=0.001). Conclusion: Based on our analytical cohort of EWLVO patients, those with severe CSVD burden were more likely to be excluded from MT and had worse functional outcomes. Poor cerebrovascular reserve and diminished collateral flow leading to rapid infarct progression in patients with greater CSVD burden may be a potential explanation.

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Reska, Nela, and Taufik Taufik. "Relathionship of Self Confidence and Academic Procrastination Students S1 Guidance and Counseling FIP UNP." Jurnal Neo Konseling 1, no. 3 (2019). http://dx.doi.org/10.24036/00138kons2019.

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Academic Procrastination is one's job to replace his tasks or work which causes failure to complete tasks / work on time. The fact that is found still increases students' academic procrastination. One of the factors that influence academic procrastination is self-confidence. This study aims to (1) Describe the level of self-confidence of S1 BK FIP UNP students (2) Describe the level of academic procrastination of S1 BK FIP UNP students (3) Test the level of significance of the relationship between student confidence with the academic proclamation of S1 BK FIP UNP students. This study uses quantitative research with a descriptive correlational type. The population of the study was 799 students of S1 BK FIP UNP and a sample of 266 students were selected by stratified random sampling. The instruments used are the scale of academic procrastination and self-confidence scale. Analysis of data with descriptive techniques and Pearson Product Moment techniques with the help of the SPSS program for windows 20.00. The research findings explain that: (1) the level of academic procrastination of students on average in the medium category with a percentage of 45.9% (2) the level of student confidence average in the high category with a percentage of 56.4% (3) there is a significant negative relationship between self-confidence and academic procrastination of S1 BK FIP UNP students with a coefficient of -0.213 and a significance level of 0,000 high hopes of confidence, the faster the academic procrastination college student. The lower the confidence, the higher the academic procrastination of students. It is undeniable that there is a significant negative relationship between self-confidence and academic procrastination of S1 BK FIP UNP students.

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Zakariya, Muhammad Zakwan, Esperanza Palenzuela, Rebekah Sutherland, and Khalida Ann Lockman. "P34 Gentamicin labels: improving the timing of gentamicin levels and reducing delay in dose administrations." JAC-Antimicrobial Resistance 5, Supplement_2 (2023). http://dx.doi.org/10.1093/jacamr/dlad066.038.

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Abstract Background Due to its narrow therapeutic index and significant risks of ototoxicity and nephrotoxicity, gentamicin requires meticulous prescribing, administration and monitoring. Despite readily available guidelines, gentamicin use continues to be associated with errors, with recent Datix reports within NHS Lothian recording incidents such as incorrectly prescribed doses or frequencies, missed levels, and delayed or omitted doses. In response to this, an audit was undertaken to investigate errors in gentamicin use within the Acute Medical Unit (AMU) at the Royal Infirmary of Edinburgh and evaluate the barriers to adherence to guidelines to unearth possible areas for improvement. Methods The initial audit studied patients prescribed gentamicin in AMU within a 3-week period, excluding those who received prophylactic or single one-off doses of gentamicin. The following parameters were examined both on their paper and electronic prescribing charts: (i) dose, (ii) dosing interval/frequency, (iii) time of level sampling, and (iv) administration times of the first and second gentamicin doses. After identifying issues with delayed gentamicin levels and subsequent dose administration times, we introduced the use of gentamicin labels in each AMU bay, in hopes of increasing staff awareness towards patients on gentamicin, thereby promoting timely level sampling and dose administration. The aforementioned parameters were re-audited for a further 3 weeks following this intervention. Results The baseline audit highlighted that only 23/31 (74%) patients had levels taken within the recommended window, and 23/31 (74%) received their second gentamicin doses at the right time. Following the introduction of the gentamicin labels, the second audit observed a slight improvement, with 31/40 (78%) patients having their levels taken within the recommended window, and 30/40 (75%) patients receiving their subsequent doses at the right interval. Noteworthily, in both the pre- and post-intervention groups, the majority of patients who had their second doses delayed received their first doses in the emergency department (ED) prior to admission to AMU. Conclusions In addition to improving staff awareness towards patients on gentamicin, a further overarching issue needs to be addressed: the delays in gentamicin administration which more commonly occurs for patients who transition from ED into AMU. Further interventions should therefore target improving the handover of time-critical medicines between ED and AMU.

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Beier, Grischa, Silke Niehoff, and Mandy Hoffmann. "Industry 4.0: a step towards achieving the SDGs? A critical literature review." Discover Sustainability 2, no. 1 (2021). http://dx.doi.org/10.1007/s43621-021-00030-1.

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AbstractThe transformation of industrial production is one of the big challenges on the pathway to sustainable development. Therefore, expectations regarding the contribution of Industry 4.0 are high. So far there is only little research focusing on the relation between the Sustainable Development Goals (SDGs) of the United Nations 2030 Agenda and the digitalization of industrial processes. We argue that sustainability aspects must be an integral part of Industry 4.0 implementation to support a sustainable development. For that reason, the digital manufacturing concept itself must take essential characteristics of sustainability into account. Our analysis has investigated to what extent sustainability aspects are currently reflected in the most recognized articles about Industry 4.0. For that purpose, we have conducted a systematic literature review, in which we have analysed the top cohort of most frequently cited articles published after 2013 on GoogleScholar dealing with “Industry 4.0”. Our literature review reveals that the descriptions reflect many expectations and hopes while only few of them are evidence-based. According to our results Industry 4.0 mainly deals with the economic dimension of sustainability such as growth and productivity. Although there are expectations that Industry 4.0 creates a window of opportunity for a more sustainable production, we could not find evidence to support this idea. Instead of targeting a more sustainable production, many descriptions draw a picture in which Industry 4.0 processes run exactly as before, just in a digital way.

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Nakash, Maayan, and Dan Bouhnik. "“A system that will do magic”: organizational perspective on the technological layer in knowledge management." Aslib Journal of Information Management, April 1, 2022. http://dx.doi.org/10.1108/ajim-11-2021-0341.

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PurposeThis study aims to give expression, for the first time, to the contemporary perceptions of knowledge management (KM) professionals regarding the technological layer in KM. From an organizational-holistic view, the authors strive to provide a deeper understanding of the position and role of technology in KM in knowledge-intensive organizations.Design/methodology/approachAs part of the adoption of the qualitative-constructivist paradigm, the research started with in-depth interviews and continued with focus groups. The data were collected from 21 KM experts and analyzed according to the thematic analysis method, based on the grounded theory.FindingsAlthough many hopes depend on technological tools, the authors learn why KM cannot be considered a purely information technology (IT)-based process. The study raises significant concern regarding the leadership of KM efforts by IT units, due to the possible lack of focus on strategic aspects supported by that support closing knowledge gaps. KM experts support technological changes and anticipate the introduction of automated mechanisms for knowledge flow processes.Originality/valueUnderstanding the technological component of KM provides a window of opportunity for the meanings ascribed by the professionals to the whole KM discipline. The results improve the understanding that the KM community should be required to be more aware of the business-organizational aspects for which the practice of KM in the organization is required, as well as the centrality of human resources in knowledge creation and sharing. Moreover, the paper provides a unique glimpse into the future of organizational KM.

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Cuesta-Valiño, Pedro, Pablo Gutiérrez-Rodríguez, and Patricia Durán-Álamo. "Why Do People Return to Video Platforms? Millennials and Centennials on TikTok." Media and Communication 10, no. 1 (2022). http://dx.doi.org/10.17645/mac.v10i1.4737.

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While some social networks like Facebook are losing interest among digital influencers, TikTok continues to grow, capturing and impacting centennials and millennials alike. This situation highlights the new generations’ increasing interest in short video formats, which are also becoming a new window of communication between companies and consumers. TikTok allows users to create, share, and discover short, user-generated videos in hopes of attracting viewers. But it is necessary to understand the variables that attract and engage users of these particular social networks. This article analyses the variables of continuance motivation, video sharing behaviour, and video creation capabilities, which allow users to enjoy such networks, and service providers and companies to obtain results from them. The aim is to understand how these variables motivate social media users to return to and spend more time on this video-sharing platform. This is measured through the stickiness variable. In this context—and due to the particular relevance of the topic—the authors also aim to reveal any potential differences in the behaviour of centennials and millennials when using TikTok. Therefore, a cross-sectional study was conducted through a questionnaire answered by 2,301 millennials and centennials who use TikTok. The data were analysed through a structural equation model to measure the relevance of each of the variables to stickiness. The results provide guidelines for improving research on video social media platforms, as well as an opportunity to explore the importance of the selected variables to the stickiness variable across different user segments.

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Spitznagel, Katya, Miranda Sadar, Erin Willis, and Joao Brandao. "Intramuscular Alfaxalone Effective Dose (ED) Determination and Cardiopulmonary Effects of ED99 in Sonoran Desert Toads (Incilius alvarius)." Journal of Herpetological Medicine and Surgery, August 2, 2023. http://dx.doi.org/10.5818/jhms-d-23-00004.

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There is limited knowledge on amphibian sedation, and drug doses appear to be species-specific and affected by the administration route. Alfaxalone, a neuroactive steroid, has gained popularity in veterinary medicine and has been evaluated in some amphibian species. Previous studies in amphibians have demonstrated a sedative dose range of 10-30 mg/kg IM. No peer-review publication has investigated this drug in Sonoran Desert toads specifically. Therefore, the purpose of this study was to 1) determine the effective dose 50 (ED50) of IM alfaxalone for sedation and 2) determine the cardiopulmonary effects of the effective dose 99 (ED99) in 13 Sonoran Desert toads. Using the Dixon’s Up-and-Down method, the ED50 was calculated as 9.02 mg/kg while using a non-linear regression, the calculated ED50 was 9.65 mg/kg, and the ED99 was 9.91 mg/kg. Based on these results, 10 mg/kg IM was administered, and its cardiovascular effects were determined for 120 mins post-injection. The 10 mg/kg IM dose resulted in significant transient cardiorespiratory depression in all toads, with most toads (11/13) showing signs of sedation (recumbency and/or loss of righting reflex) within 30–40-minutes post-injection. There was no associated mortality with this study, and the side effects associated with this dosage (cardiorespiratory depression, ventral erythema, dysphoric behavior such as rolling and head pressing) resolved in all toads prior to the end of the 120-minute observation window. This study hopes to increase the understanding of the clinical application and limitations of this drug for sedation of Sonoran Desert toads.

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