Littérature scientifique sur le sujet « Hippocampal mossy fibers »
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Articles de revues sur le sujet "Hippocampal mossy fibers"
Hendricks, William D., Gary L. Westbrook et Eric Schnell. « Early detonation by sprouted mossy fibers enables aberrant dentate network activity ». Proceedings of the National Academy of Sciences 116, no 22 (13 mai 2019) : 10994–99. http://dx.doi.org/10.1073/pnas.1821227116.
Texte intégralOtsu, Yo, Eiichi Maru, Hisayuki Ohata, Ichiro Takashima, Riichi Kajiwara et Toshio Iijima. « Optical Recording Study of Granule Cell Activities in the Hippocampal Dentate Gyrus of Kainate-Treated Rats ». Journal of Neurophysiology 83, no 4 (1 avril 2000) : 2421–30. http://dx.doi.org/10.1152/jn.2000.83.4.2421.
Texte intégralFrotscher, M., E. Soriano et U. Misgeld. « Divergence of hippocampal mossy fibers ». Synapse 16, no 2 (février 1994) : 148–60. http://dx.doi.org/10.1002/syn.890160208.
Texte intégralWilliams, Brent L., Mady Hornig, Kavitha Yaddanapudi et W. Ian Lipkin. « Hippocampal Poly(ADP-Ribose) Polymerase 1 and Caspase 3 Activation in Neonatal Bornavirus Infection ». Journal of Virology 82, no 4 (5 décembre 2007) : 1748–58. http://dx.doi.org/10.1128/jvi.02014-07.
Texte intégralOkazaki, Maxine M., Péter Molnár et J. Victor Nadler. « Recurrent Mossy Fiber Pathway in Rat Dentate Gyrus : Synaptic Currents Evoked in Presence and Absence of Seizure-Induced Growth ». Journal of Neurophysiology 81, no 4 (1 avril 1999) : 1645–60. http://dx.doi.org/10.1152/jn.1999.81.4.1645.
Texte intégralKress, Geraldine J., Margaret J. Dowling, Julian P. Meeks et Steven Mennerick. « High Threshold, Proximal Initiation, and Slow Conduction Velocity of Action Potentials in Dentate Granule Neuron Mossy Fibers ». Journal of Neurophysiology 100, no 1 (juillet 2008) : 281–91. http://dx.doi.org/10.1152/jn.90295.2008.
Texte intégralRuiz, Arnaud, Ruth Fabian-Fine, Ricardo Scott, Matthew C. Walker, Dmitri A. Rusakov et Dimitri M. Kullmann. « GABAA Receptors at Hippocampal Mossy Fibers ». Neuron 39, no 6 (septembre 2003) : 961–73. http://dx.doi.org/10.1016/s0896-6273(03)00559-2.
Texte intégralPan, Enhui, Zirun Zhao et James O. McNamara. « LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling ». Journal of Neurophysiology 121, no 2 (1 février 2019) : 609–19. http://dx.doi.org/10.1152/jn.00669.2018.
Texte intégralSekino, Yuko, Kunihiko Obata, Manabu Tanifuji, Makoto Mizuno et Jin Murayama. « Delayed Signal Propagation via CA2 in Rat Hippocampal Slices Revealed by Optical Recording ». Journal of Neurophysiology 78, no 3 (1 septembre 1997) : 1662–68. http://dx.doi.org/10.1152/jn.1997.78.3.1662.
Texte intégralScharfman, Helen E. « Does the Development of a GABAergic Phenotype by Hippocampal Dentate Gyrus Granule Cells Contribute to Epileptogenesis ? » Epilepsy Currents 2, no 2 (mars 2002) : 63. http://dx.doi.org/10.1111/j.1535-7597.2002.00023.x.
Texte intégralThèses sur le sujet "Hippocampal mossy fibers"
Caiati, Maddalena Delma. « Activity-dependent regulation of GABA release at immature mossy fibers-CA3 synapses : role of the Prion protein ». Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/4719.
Texte intégralBastian, Chinthasagar. « The Role of Synaptically Released Free Zinc in the Zinc Rich Region of Epileptic Mammalian Hippocampal Circuitry ». Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1276717130.
Texte intégralPineda, Victor Viray. « A genetic and pharmacological dissection of synaptic plasticity in the hippocampus / ». Thesis, Connect to this title online ; UW restricted, 2003. http://hdl.handle.net/1773/6290.
Texte intégralGundlfinger, Anja. « The hippocampal mossy fiber synapse ». Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2008. http://dx.doi.org/10.18452/15763.
Texte intégralChemical synapses are key elements for the communication between nerve cells. This communication can be regulated on various time scales and through different mechanisms affecting synaptic transmission. Amongst these are slow and long-lasting adjustments by endogenous neuromodulators, instantaneous and reversible activity-dependent regulation by short-term plasticity and persistent activity-dependent changes by long-term plasticity. Within this thesis, we have investigated several aspects of modulation of synaptic transmission and its functional relevance at the example of the hippocampal mossy fiber synapse. The presented results were acquired through electrophysiological and microfluorometric experiments at the hippocampal formation of mice and could be verified and substantiated through theoretical analyses, simulations and computational modelling.
Wallis, James. « Synaptic plasticity of the hippocampal mossy fibres in vivo ». Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.680382.
Texte intégralLalic, Tatjana. « Synaptic transmission of hippocampal mossy fibres in health and disease ». Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:cb37e4ad-f00a-4fb5-b4b4-5f8a55c3c64c.
Texte intégralZucca, Stefano. « Analysis of synaptic function of CA3 microcircuit in vivo using optogenetic tools ». Thesis, Bordeaux 2, 2013. http://www.theses.fr/2013BOR22127.
Texte intégralThe hippocampus is a brain region located in the medial temporal lobe. Along with other limbic structures, the hippocampus is involved in learning and memory processes and has a crucial role in spatial information processing. Within the hippocampus synapses made between mossy fibers (mf) originating from the dentate gyrus and CA3 pyramidal neurons have received particular attention, given the strategic position occupied by the dentate gyrus at the entrance of the hippocampus. Moreover mf-CA3 synapses are distinct from most of other excitatory synapses in the central nervous system for their unusual morphological and physiological properties. This raises the question if these unique properties reflect a unique functional role in information processing carried out by this synapse within the microcircuit of the hippocampus. Unfortunately very little is known on how granule cells modulate the activity of CA3 neurons in the intact network in vivo (Henze et al., 2002; Hagena and Manahan-Vaughan, 2010, 2011). The paucity of information is due to the fact that classical manipulation of neuronal circuits using electrical, pharmacological and genetic approaches lack spatial and temporal precision in vivo. The use of bulk extracellular stimulation may lead to polysynaptic activation of CA3 pyramidal cells, which can subsequently contaminate putative mossy fibers synaptic responses measured in CA3 pyramidal cells. The use of overly conservative criteria on the other side may lead to the exclusion of “pure” mossy fibers responses with unexpected properties (Henze et al., 2000).However the recent and fast growth of optogenetics in neuroscience has provided new tools with high spatial selectivity (cell specific optical activation) and temporal precision (at the millisecond scale), allowing the dissection and investigation of neuronal circuits in vivo. The aim of my thesis was to gain insight into the mechanisms and the physiological consequences of short-term synaptic plasticity occurring at mossy fibers to CA3 pyramidal neurons synapses in the intact mouse brain. The present thesis consists of two main parts. In the first part I explored new optogenetic tools to control the activity of granule cells with pulses of light. Optogenetic stimulation, which relies on the activation of the light-gated ion channel channelrhodopsin-2 (ChR2) by blue light reliably induced action potentials over a wide range of frequencies of stimulation. I also found that optical stimulation can be used to trigger short term plasticity at mf-CA3 synapses. In the second part I refined optogenetic stimulation methodology in vivo for non-invasive characterization of synaptic functioning of the mf-CA3 synapses. The reliability of optogenetic stimulation of a genetically targeted neuronal population together with the single cell resolution obtained using whole-cell recordings are important steps towards a better understanding of the functional role of the mossy fibers in the hippocampal network in vivo
Gonzalez, i. Llinares Bernat. « Presynaptic mechanisms of short-term plasticity at hippocampal mossy fibersynapses ». Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0424/document.
Texte intégralThe hippocampal mossy fiber is characterized by its particular morphology, distinctsynaptic transmission and presynaptic plasticity. Moreover, this synapse has beencalled ―teacher‖ or ―detonator‖ for its proposed functional role in episodic memoryencoding. Nevertheless, the molecular mechanisms underlying its specific functionalproperties remain elusive. This work is composed of two main parts:1) Phenotyping Hippocampal Mossy Fiber Synapses in VAMP7 KO MiceVAMP7 is a vesicle SNARE of the longin family important in neurite growth duringdevelopment. In the adult brain, VAMP7 is enriched in a subset of nerve terminals,particularly at the hippocampal mossy fiber. We analyzed VAMP7 function inneurotransmitter release by characterizing basal and evoked transmission at thissynapse in KO mice and fully tested hypotheses relevant to short-term plasticity.Loss of VAMP7 has been previously reported not to cause major developmental orneurological deficits (Sato et al., 2011; Danglot et al., 2012). Presynapticmechanisms of short-term plasticity at the hippocampal mossy fiber also seemunaffected for potential reasons that will be discussed.2) CA3 Circuits Probed with RABV-Tracing and Paired RecordingsWe developed a technique to establish paired recordings between connected dentategyrus granule cells and CA3 pyramidal cells (GC-CA3) in mouse hippocampalorganotypic slice cultures. To identify direct presynaptic partners to a defined targetCA3 pyramidal cell, we combined single-cell electroporation (SCE) and mono-transsynaptictracing based on a pseudotyped, recombinant rabies virus (EnvApseudotyped RABV ΔG). Using SCE we transfected a single CA3 pyramidal cell perslice with the plasmids encoding: the RABV envelope glycoprotein (RG), afluorescent reporter, and TVA (the EnvA cognate surface receptor, which has nohomologue in mammalian cells). The slices were subsequently infected with EnvApseudotyped RABV ΔG. After 3-4 days, the RABV mono-trans-synaptic tracingrevealed the presynaptic inputs of that single neuron. Then, we were able toestablish paired recordings between connected GC-CA3 cells, as well as to quantifythe presynaptic partners of the starter CA3 pyramidal cell
De mosvezel van de hippocampus kenmerkt zich door een bijzondere morfologie,uitzonderlijke synaptische transmissie en presynaptische plasticiteit. De synapswordt ook wel "leraar" of "detonator" genoemd vanwege zijn waarschijnlijke rol in decodering van het episodisch geheugen. Toch blijven de specifieke moleculairemechanismen van dit synaps onbekend. Dit werk bestaat uit twee delen:1) Fenotypering van mosvezel synapsen van de hippocampus in VAMP7 KO muizenVAMP7 is een vesicle-SNARE van de longin familie van belang bij de groei vanneurieten tijdens de ontwikkeling. In de volwassen hersenen, wordt VAMP7 verrijkt ineen subset van zenuwuiteinden, vooral in de mosvezel van de hippocampus. Weanalyseerden VAMP7 functie in neurotransmitter afgifte door het karakteriseren vanbasale en opgeroepen transmissie bij deze synaps in KO muizen. Eerder is algesteld dat gebrek aan VAMP7 niet leidt tot grote ontwikkelings- of neurologischeafwijkingen (Sato et al., 2011; Danglot et al., 2012). Presynaptische mechanismenvan korte termijn plasticiteit in de mosvezel van de hippocampus lijken ookonaangetast te zijn, de mogelijke redenen hiervoor zullen worden besproken.2) CA3 circuits onderzocht met behulp van RABV-tracing en gekoppelde opnamesWe ontwikkelden een techniek om gekoppelde opnames tussen korelcellen van degyrus dentatus en aangesloten CA3 piramidale cellen (KC-CA3) op zogenaamde‗mouse hippocampal organotypic slice cultures‘ te meten. Om rechtstreeksepresynaptische partners te identificeren van een specifieke CA3 piramidale cel,combineerden we single-cell electroporation (SCE) en mono-trans-synaptic tracingop basis van een pseudo-typed, recombinant rabiësvirus (EnvA pseudogetypedRABV ΔG). Met behulp van SCE transfecteerde we één CA3 piramidale cel per slicemet plasmiden die coderen voor: het RABV glycoproteïne-envelop (RG), eenfluorescerende reporter, en TVA (de aan EnvA verwante oppervlakte receptor diegeen homoloog in zoogdiercellen heeft). De slices werden vervolgens geïnfecteerdmet ENVA pseudogetyped RABV ΔG. Na 3-4 dagen bracht de RABV mono-transsynaptischetracing de presynaptische ingangen van die ene neuron aan het licht.Hierna konden we gekoppelde opnames doen tussen verbonden KC-CA3 cellen.Daarnaast konden we de presynaptische partners van de starter CA3 pyramidale celkwantificeren
Maingret, Vincent. « Modulation de la plasticité synaptique par les prostaglandines E2 à la synapse fibre moussue/cellule pyramidale CA3 en conditions physiologiques et dans un modèle murin de la maladie d'Alzheimer ». Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0313/document.
Texte intégralAlzheimer’s disease (AD) is the most common form of dementia in elder people characterized by a loss of cognitive function linked to synaptic deficits. There is considerable evidence that neuroinflammation and AD are intimately linked. The key role of neuroinflammation in the course of the disease was figured out by epidemiological studies reporting a reduced prevalence to develop AD for patients chronically treated with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Prostaglandins are lipidic mediators derived from arachidonic acid and their synthesis is inhibited by NSAIDs. Among prostaglandins, PGE2 is known to modulate synaptic transmission and plasticity in the hippocampus and its concentration is higher in brains from AD patients. Numerous studies have reported synaptic deficits in the course of AD, mainly in the hippocampus which is essential for cognitive functions like learning or memory formation. The vast majority of these studies were focused on postsynaptic deficits at the canonical CA3-CA1 synapse. On the opposite, the synapse between mossy fiber and CA3 pyramidal cell (Mf-CA3) that express presynaptic short-term and long-term plasticity, was poorly studied in the context of AD. The aim of my project was to decipher the involvement of PGE2 in synaptic deficits in a mouse model of AD, the APPswe/PS1ΔE9 (APP/PS1). Our results show that acute application of PGE2 on wild type young mice impairs only presynaptic long term potentiation (LTP) at the Mf-CA3 synapse via the specific activation of EP3 receptor. In APP/PS1 mice, we demonstrate that the sole deficit at the Mf-CA3 synapse is an impairment of the presynaptic LTP at 12 months of age. Finally we demonstrate that the impaired presynaptic LTP in APP/PS1 mice can be rescued by the acute application of a specific EP3 receptor antagonist, pointing out the key role of PGE2 - EP3 signaling pathway in synaptic deficits in hippocampus in a mouse model of AD
Kourdougli, Nazim. « Hippocampal structural reactive plasticity in a rat model of temporal lobe epilepsy : chloride homeostasis as a keystone ». Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4091.
Texte intégralThe present dissertation undertakes to investigate the early triggering events of the mossy fiber sprouting (MFS) in the dentate gyrus, a hallmark of hippocampal reactive plasticity in Temporal Lobe Epilepsy (TLE). We used the rat pilocarpine model of TLE to show that altered GABAA receptor-mediated transmission play a key role in the formation of early ectopic MFS during epileptogenesis. This is likely due to a compromised chloride homeostasis, as a result of increased expression of chloride loader NKCC1 and downregulation of the neuronal chloride extruder KCC2. We next addressed the mechanistic action of depolarizing GABAAR responses with regard to neurotrophin signaling. Our findings uncovered that the pan neurotrophin receptor p75 (p75NTR) mediated the sculpting action of depolarizing GABAAR responses on the ectopic MFS. Blockade of depolarizing GABAAR responses using the loop diuretic bumetanide reduced abnormal p75NTR subsequently decreased the ectopic MFS. Finally, transitory application of bumetanide during epileptogenesis resulted in reduction of spontaneous and recurrent seizures during the chronic phase of TLE. The rationale of this work is that unveiling the molecular mechanisms underlying the hippocampal post-seizure glutamatergic network rewiring will help to drive future novel therapeutic avenues involving chloride homeostasis and neurotrophin interplay. Overall, this dissertation shed a new light on how GABAergic transmission and neurotrophin signaling crosstalk can orchestrate reactive hippocampal plasticity in TLE
Chapitres de livres sur le sujet "Hippocampal mossy fibers"
Delprato, Anna, et Wim E. Crusio. « Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse ». Dans Methods in Molecular Biology, 419–30. New York, NY : Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6427-7_19.
Texte intégralJohnston, D., W. F. Hopkins et R. Gray. « Norepinephrine Enhances Long-Term Potentiation at Hippocampal Mossy Fiber Synapses ». Dans Synaptic Plasticity in the Hippocampus, 57–60. Berlin, Heidelberg : Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73202-7_17.
Texte intégralRepresa, Alfonso, Evelyne Tremblay et Yehezkel Ben-Ari. « Sprouting of Mossy Fibers in the Hippocampus of Epileptic Human and Rat ». Dans Excitatory Amino Acids and Neuronal Plasticity, 419–24. Boston, MA : Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5769-8_46.
Texte intégralSchwegler, H., B. Heimrich, W. E. Crusio et H. P. Lipp. « Hippocampal Mossy Fiber Distribution and Two-Way Avoidance Learning in Rats and Mice ». Dans Brain Plasticity, Learning, and Memory, 127–38. Boston, MA : Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5003-3_14.
Texte intégralSchwegler, Herbert, Bernd Heimrich et Hanspeter Lipp. « Effects of Early Hyperthyroidism on Shuttle Box Behavior and Hippocampal Mossy Fiber Distribution ». Dans Brain Plasticity, Learning, and Memory, 578. Boston, MA : Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5003-3_88.
Texte intégralDorman, R. V., T. F. R. Hamm, D. S. Damron et E. J. Freeman. « Modulation of Glutamate Release From Hippocampal Mossy Fiber Nerve Endings By Arachidonic Acid And Eicosanoids ». Dans Neurobiology of Essential Fatty Acids, 121–36. Boston, MA : Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3426-6_11.
Texte intégralSafiulina, Victoria F., Majid H. Mohajerani, Sudhir Sivakumaran et Enrico Cherubini. « GABA is the Main Neurotransmitter Released from Mossy Fiber Terminals in the Developing Rat Hippocampus ». Dans Co-Existence and Co-Release of Classical Neurotransmitters, 1–18. Boston, MA : Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-09622-3_6.
Texte intégralSugiyama, Hiroyuki, Isao Ito et Daisuke Okada. « Roles of Metabotropic and Ionotropic Glutamate Receptors in the Long-Term Potentiation of Hippocampal Mossy Fiber Synapses ». Dans Excitatory Amino Acids and Neuronal Plasticity, 387–94. Boston, MA : Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5769-8_42.
Texte intégralCherubini, Enrico, Maddalena D. Caiati et Sudhir Sivakumaran. « In the Developing Hippocampus Kainate Receptors Control the Release of GABA from Mossy Fiber Terminals via a Metabotropic Type of Action ». Dans Advances in Experimental Medicine and Biology, 11–26. Boston, MA : Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-9557-5_2.
Texte intégralM.C. Bastos, Fatima, Carlos M. Matias, Ines O. Lopes, João P. Vieira, Rosa M. Santos, Luis M. Rosario, Rosa M. Quinta-Ferreira et Maria Emilia Quinta-Ferreira. « FAD-Linked Autofluorescence and Chemically-Evoked Zinc Changes at Hippocampal Mossy Fiber-CA3 Synapses ». Dans Hippocampus - Cytoarchitecture and Diseases. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.100898.
Texte intégralActes de conférences sur le sujet "Hippocampal mossy fibers"
Bastos, Fatima C., Sandra A. Lopes, Vanessa N. Corceiro, Carlos M. Matias, Paulo J. B. Mendes, Fernando D. S. Sampaio dos Aidos, Jose C. Dionisio, Rosa M. Quinta-Ferreira et M. Emilia Quinta-Ferreira. « Zinc changes evoked by phenolic compounds and effect on TEA-LTP at hippocampal mossy fiber synapses ». Dans 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG). IEEE, 2015. http://dx.doi.org/10.1109/enbeng.2015.7088825.
Texte intégralBastos, Fatima C., Sandra A. Lopes, Vanessa N. Corceiro, Jose C. Dionisio, Carlos M. Matias, Paulo J. B. Mendes, Fernando D. S. Sampaio dos Aidos, Rosa M. Quinta-Ferreira et M. Emilia Quinta-Ferreira. « Zinc changes evoked by phenolic compounds and effect on TEA-LTP at hippocampal mossy fiber synapses ». Dans 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG). IEEE, 2015. http://dx.doi.org/10.1109/enbeng.2015.7088873.
Texte intégralRapports d'organisations sur le sujet "Hippocampal mossy fibers"
Terrian, David M. Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse. Fort Belvoir, VA : Defense Technical Information Center, octobre 1991. http://dx.doi.org/10.21236/ada243381.
Texte intégralTerrian, David M. Presynaptic Modulation of the Hippocampal Mossy Fiber Synapse. Fort Belvoir, VA : Defense Technical Information Center, septembre 1990. http://dx.doi.org/10.21236/ada229105.
Texte intégralJohnston, Daniel. Heterosynaptic Modulation of Long-Term Potentiation at Mossy Fiber Synapses in Hippocampus. Fort Belvoir, VA : Defense Technical Information Center, mai 1991. http://dx.doi.org/10.21236/ada238027.
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