Thèses sur le sujet « GLS1 »
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Hasan, Bou Issa Lama. « Étude des dépendances génomiques dans le myélome multiple surexprimant MYC ». Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS011.
Texte intégralMultiple myeloma (MM) is a hematological malignancy that accounts for around 13% of hematological cancers and is characterized by the uncontrolled proliferation of malignant plasma cells in the bone marrow. MM progresses from precursor stages, known as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM), to the symptomatic form, MM. It is an incurable malignancy in which heterogeneity and clonal evolution allow treatment escape and disease progression. MYC alterations play an essential role in this progression. However, MYC is not therapeutically targetable due to its nuclear localization and the protein's short half-life.To overcome this, we hypothesized that the proliferative advantage induced by MYC overexpression creates genomic dependencies on other signalling pathways that become essential for cell survival. To test this hypothesis, we applied a novel approach by leveraging large-scale loss of function screen (Achilles) and 1869 small molecules screen to identify MYC-induced genomic vulnerabilities. When identified, these vulnerabilities offer an opportunity to selectively target cancer cells harbouring this overexpression and spare normal cells.Our analyses demonstrate the dependence of MYC overexpressing cells on glutamine metabolism, in particular on the GLS1 (glutaminase). We validated and functionally delineated this dependence in vitro using different approaches.Our small molecule screen highlighted that NAD synthesis inhibitors had a preferential effect on the proliferation of MYC overexpressing cells. Considering that glutamine and NAD have closely interlinked metabolic networks, we investigated the possibility of a potential synergistic effect between GLS1 and NAMPT inhibitors. We demonstrated the effectiveness of this new synergistic combination to target MYC-driven MM cells in vitro and in vivo.These results establish a solid methodological basis that can be used to develop new therapeutic approaches to address unmet therapeutic needs to target MYC in MM
Schippel-Coressel, Katja [Verfasser], et Matthias [Akademischer Betreuer] Frank. « GLP1 als Therapieoption bei Adipositas (kurz- und langwirksame GLP1 Analoga im klinischen Vergleich) / Katja Schippel-Coressel ; Betreuer : Matthias Frank ». Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/115209534X/34.
Texte intégralLi, Xingnan. « Regulation of [beta]-catenin by Gli1 in epithelial transformation ». Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2006. http://www.mhsl.uab.edu/dt/2007p/li_xingnan.pdf.
Texte intégralSeytanoglu, Adil. « Investigation of the effects of gle1 depletion in zebrafish ». Thesis, University of Sheffield, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632835.
Texte intégralHutschenreuther, Antje, Marina Bigl, Nasr Y. A. Hemdan, Tewodros Debebe, Frank Gaunitz et Gerd Birkenmeier. « Modulation of GLO1 expression affects malignant properties of cells ». Universitätsbibliothek Leipzig, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-217965.
Texte intégralHutschenreuther, Antje, Marina Bigl, Nasr Y. A. Hemdan, Tewodros Debebe, Frank Gaunitz et Gerd Birkenmeier. « Modulation of GLO1 expression affects malignant properties of cells ». MDPI, 2016. https://ul.qucosa.de/id/qucosa%3A15256.
Texte intégralLee, Jaehoon Ph D. Massachusetts Institute of Technology. « Studies of superconformal field theories using GLSM and conformal bootstrap ». Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99308.
Texte intégralCataloged from PDF version of thesis.
Includes bibliographical references (pages 273-288).
In this thesis, we study strongly interacting superconformal field theories in two and three dimensions. In two dimensions, we investigate N = (0, 2) gauge theories using the gauged linear sigma models (GLSM). In those theories, we identify simple mechanism by which worldsheet description of H-flux satisfying Green-Schwarz Bianchi identity arises. Under the renormalization group flow, we argue that these models flow into superconformal fixed points describing string theory compactifications backgrounds with non-trivial H-flux turned on. By analyzing quantum-consistency of effective theories with such mechanism, we identify conditions under which these theories to become interacting superconformal field theories in the infrared. In three dimensions, we study maximally supersymmetric (N = 8) conformal field theories by conformal bootstrap approach. We focus on studying the four-point function of stress-tensor multiplet. The superconformal blocks for the four-point function are computed by analyzing superconformal Ward identity. Using these blocks, we study crossing symmetry constraints both numerically and analytically. Doing so, we obtain universal bounds and exact relations of N = 8 superconformal field theory data.
by Jaehoon Lee.
Ph. D.
Mora, Saavedra Aquiles Andrés. « Plan de Marketing para un Bar GLS ». Tesis, Universidad de Chile, 2010. http://www.repositorio.uchile.cl/handle/2250/102472.
Texte intégralCangini, Loris. « Modern OpenGL e linguaggio GLSL per lo sviluppo di shader grafici ». Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017.
Trouver le texte intégralMcMellon, Hannah. « Structure-function studies on putative Gly1 homologues in gram-negative bacteria ». Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12921/.
Texte intégralSousa, Luiz Fernando Rosalba Telles de. « Paralelização em CUDA/GLSL do algoritmo SIFT para reconhecimento de íris ». Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=3801.
Texte intégralNeste trabalho é estudada a viabilidade de uma implementação em paralelo do algoritmo scale invariant feature transform (SIFT) para identificação de íris. Para a implementação do código foi utilizada a arquitetura para computação paralela compute unified device architecture (CUDA) e a linguagem OpenGL shading language (GLSL). O algoritmo foi testado utilizando três bases de dados de olhos e íris, o noisy visible wavelength iris image Database (UBIRIS), Michal-Libor e CASIA. Testes foram feitos para determinar o tempo de processamento para verificação da presença ou não de um indivíduo em um banco de dados, determinar a eficiência dos algoritmos de busca implementados em GLSL e CUDA e buscar valores de calibração que melhoram o posicionamento e a distribuição dos pontos-chave na região de interesse (íris) e a robustez do programa final.
Present work studies the feasibility of a parallel implementation of the scene recognition algorithm SIFT for iris recognition. The code was built using the Compute Unified Device Architecture (CUDA) and the shading language GLSL. The algorithm was tested using three databases containing eyes and iris, the UBIRIS, Michal- Libor and CASIA. Tests were made for: analyzing the requested time for checking if an subject is or is not present on current database, the efficiency of the search algorithms written in CUDA and GLSL, the search for calibration values that improve keypoints position and distribution through the region of interest (iris), analyzing the reliability of the final code.
Marcella, Barbarino. « PRIMARY CILIUM LOSS IN ADVANCED MESOTHELIOMA CORRELATES WITH CONSTITUTIVE GLI1 OVEREXPRESSION ». Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1161108.
Texte intégralAbrahamsson, Lars. « A portal based system for indoor environs ». Thesis, Linköping University, Department of Electrical Engineering, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6943.
Texte intégralThe purpose of this thesis is to document the development of the graphics part of an extremely pluggable game engine/lab environment for a course in advanced game programming. This thesis is one out of five, and concerns indoor, realtime computer 3D graphics. It covers state-of-the-art techniques such as GLSL - the OpenGL Shading Language - and more well known techniques such as portal based rendering.
Luna, Hernandez Angela 1980. « Estimação em pesquisas repetidas empregando o filtro GLS ». [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/305866.
Texte intégralDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática, Estatística e Computação Científica
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Resumo: A dissertação apresenta o processo de estimação em pesquisas repetidas sob o enfoque de séries temporais, empregando Modelos de Espaço de Estados e o filtro dos mínimos quadrados generalizados ou filtro GLS. Este filtro permite o tratamento de modelos com erros de observação autocorrelacionados de forma mais simples do que utilizando o filtro de Kalman e, além disso, possibilita a modelagem conjunta de várias subpopulações ou domínios sob restrições de benchmark obtidas a partir da mesma pesquisa. Isto não só permite manter a coerência entre as estimativas obtidas pelo método, e estimativas agregadas baseadas no planejamento da amostra, como ajuda na proteção contra possíveis erros de especificação dos modelos. Considerando o caso de amostras com rotação, também é abordado o processo de estimação da estrutura de autocorrelação dos erros amostrais empregando o método dos pseudo-erros. Via simulação, é replicado todo o procedimento de estimação, comparando resultados obtidos empregando os filtros GLS e de Kalman. Adicionalmente, é ilustrada a aplicação do filtro sob restrições de benchmark empregando a série de taxa de desemprego da Pesquisa Mensal de Emprego do IBGE, no período de março de 2002 a fevereiro de 2012
Abstract: This work presents the estimation process in repeated surveys using State Space Models and the generalized linear squares filter, GLS filter, under the time series approach. This filter deals with autocorrelated errors in the observation equation, in a simpler way than the well-known Kalman filter. Additionally, it allows for modeling jointly several domains under benchmark constraints obtained from the same survey. The benchmarking not only achieves coherence between the model-based estimates and the corresponding design-based aggregated estimates, but also provides protection against possible model failures. For the scenario of samples with a rotation scheme, the estimation of the autocorrelation structure of observational errors, using the pseudo-errors method, is also addressed. Simulation are used to compare the GLS and Kalman filter estimators. Moreover, the application of GLS filter under benchmark restrictions is illustrated, using the unemployment rate time serie from the Brazilian monthly labor force survey, from March 2002 to February 2012
Mestrado
Estatistica
Mestre em Estatística
Gu, Wei. « Gauged Linear Sigma Model and Mirror Symmetry ». Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/90892.
Texte intégralDoctor of Philosophy
In this thesis, I summarize my work on gauged linear sigma models (GLSMs) and mirror symmetry. We begin by using supersymmetric localization to show that A-twisted GLSM correlation functions for certain supermanifolds are equivalent to corresponding A-twisted GLSM correlation functions for hypersurfaces. We also define associated Cartan theories for non-abelian GLSMs. We then consider N =(0,2) GLSMs. For those deformed from N =(2,2) GLSMs, we consider A/2-twisted theories and formulate the genus-zero correlation functions on Coulomb branches. We reproduce known results for abelian GLSMs, and can systematically compute more examples with new formulas that render the quantum sheaf cohomology relations and other properties are manifest. We also include unpublished results for counting deformation parameters. We then turn to mirror symmetry, a duality between seemingly-different two-dimensional quantum field theories. We propose an extension of the Hori-Vafa mirror construction [25] from abelian (2,2) GLSMs to non-abelian (2,2) GLSMs with connected gauge groups, a potential solution to an old problem. In this thesis, we study two examples, Grassmannians and two-step flag manifolds, verifying in each case that the mirror correctly reproduces details ranging from the number of vacua and correlations functions to quantum cohomology relations. We then propose an extension of the HoriVafa construction [25] of (2,2) GLSM mirrors to (0,2) theories obtained from (2,2) theories by special tangent bundle deformations. Our ansatz can systematically produce the (0,2) mirrors of toric varieties and the results are consistent with existing examples. We conclude with a discussion of directions that we would like to pursue in the future.
Kiani, Amineh Gholam Hossien. « Subcloning, purification and characterization of the GLY1 gene product of Saccharomyces cerevisiae ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0003/MQ28782.pdf.
Texte intégralTadioto, Mateus Vitor. « O lugar discursivo do sujeito no segmento turístico GLS ». reponame:Repositório Institucional da UCS, 2016. https://repositorio.ucs.br/handle/11338/1679.
Texte intégralSubmitted by Ana Guimarães Pereira (agpereir@ucs.br) on 2017-02-22T12:35:16Z No. of bitstreams: 1 Dissertacao Mateus Vitor Tadioto.pdf: 850366 bytes, checksum: d7682b9c97166d505e84291c4588fb37 (MD5)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES.
This dissertation relates to the discourse analysis proposed by the French philosopher Michel Pêcheux and it has as the main theme the discussions on the structuration process of the academic discourse which addresses the segmentation of Tourism in Brazil. With this research, I aim to contribute with the study in the Field of Tourism from a critical perspective, with emphasis on GLS Tourism. For this purpose, I have searched in books (published in Brazil and written within the national academic community) for texts that relates Tourism with the LGBT Community, addressing to the construction of this concept. From this search, I have related three texts which assemble the analysis corpus: Angeli (2004 [1999]), Oliveira (2002) and Trigo (2009). From the view of the materiality‟s sequential discourses and the mobilization of concepts like Social Formation, Ideological Formation, Discursive Place, Discursive Formations and Subject-Form, I have developed a theorical method which intends to discuss the appropriation of the acronym “GLS” (expressed within the LGBT Movement as a Discursive Place) by the Market and, inevitably, by the Academy. From these analysis findings, I also point to the conceptual treatment given to the subject in the processes of segmentation of Tourism, which refer to the individualism and pragmatism, endorsing that the segmentation is still based on too reductionist perspectives. In this effort to question the segment, the text is left open, mobilizing other inquires and propositions of new arrangements within the Tourism – Discourse Analysis interface.
Perron, Pierre, et Gabriel Rodríguez. « GLS detrending, efficient unit root tests and structural change ». Economía, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/117533.
Texte intégralExtendemos los estadísticos tipo M para una raíz unitaria analizados por Perron y Ng (1996) y Ng y Perron (2001) al caso donde se permite que el cambio en la función de tendencia ocurra en un punto desconocido. Estos estadísticos (MGLS) adoptan el enfoque GLS para eliminar la tendencia desarrollado por Elliott et al. (1996) (ERS) siguiendo los resultados de Dufour y King (1991). Siguiendo a Perron (1989), consideramos dos modelos: uno que permite un cambio en la pendiente y otro que permite tanto un cambio en el intercepto como en la pendiente. Derivamos las distribuciones asintóticas así como el estadístico óptimo factible en un punto de la hipótesis alternativa (PT GLS) sugerido por ERS. También computamos el parámetro de no centralidad utilizado por el enfoque GLS local a la unidad con el fin de eliminar la tendencia que permite que el estadístico PT GLS tenga 50% de potencia asintótica en ese valor. Asimismo, se han tabulado los valores críticos asintóticos de los estadísticos. Mostramos que los estadísticos MGLS y PT GLS tienen una función de potencia asintótica cercana a la envolvente de potencia. Un estudio de simulación analiza el tamaño y potencia en muestras finitas bajo varios métodos para seleccionar la truncación para estimar la densidad espectral autorregresiva. Finalmente, también se presenta una aplicación empírica.
Masadah, Rina. « Generation of transgenic mice overexpressing human Smoothened and human GLI1 genes in their skin / ». [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19678.pdf.
Texte intégralTarrant, Jessica. « Structural and functional studies of proteins expressed from the gly1 locus of pathogenic Neisseria ». Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22706/.
Texte intégralHavsvik, Oskar. « Enhanced Full-body Motion Detection for Web Based Games using WebGL ». Thesis, Linköpings universitet, Institutionen för datavetenskap, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119736.
Texte intégralGoodwani, Sunil G. « Amoxicillin and Augmentin Reduce Ethanol Intake and Increase GLT1 Expression as well as AKT Phosphorylation in Mesocorticolimbic Regions ». University of Toledo Health Science Campus / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=mco1403873055.
Texte intégralBRAMBILLA, MARCO. « Rewiring yeast nitrogen and mRNA metabolism for eliciting industrially relevant phenotypes. The Saccharomyces cerevisiae glutamate synthase (Glt1) and the poly(A) binding protein (Pab1) as case studies ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/198932.
Texte intégralNowadays, for the production of energy and materials, our society mainly relies on fossil sources, but many concerns arise from their utilization, like greenhouse gases emission and non-renewability within the time of their consumption. Hence, biorefineries, which convert renewable biomasses into products and energy, could be a promising alternative. Despite some biorefineries are now at commercial scale, many challenges must be overcome to implement competitive bio-based industries, such as improving the performances of microorganisms, named cell factory, used during the production processes. Above all, the yeast Saccharomyces cerevisiae is the most prominent cell factory for producing bioethanol as biofuel. The main objective of this thesis was to engineer S. cerevisiae strains with biotechnological interesting traits, among which improved growth performances and increased thermotolerance. For this purpose, we investigated and applied a cellular rewiring, by selecting two targets: the glutamate synthase Glt1 that is an enzyme of the central nitrogen metabolism, CNM, and the main polyA binding protein Pab1, a master regulator of mRNA metabolism. Regarding GLT1, the physiological effects of its deletion and over-expression were assessed by growing yeasts in the presence of different nitrogen sources. Results showed that the supplementation of ammonium sulfate, glutamate or glutamine considerably affects growth, protein content, viability and reactive oxygen species, ROS, accumulation. Conversely, GLT1 modulation does not significantly influence these parameters. Overall, these data highlight the plasticity of the S. cerevisiae CNM in respect to the environment and confirm its robustness against internal perturbation. Moreover, even though the sole modulation of GLT1 expression might not reprogram the entire cell, the physiological characterization of this study might be helpful to guide the selection of other more promising candidate for the application of the rewiring approaches. Then, the induction of cellular reprogramming was assessed selecting Pab1. To this purpose, a strain carrying the unaltered PAB1 chromosomal allele was transformed with a PAB1 plasmid mutant library and then screened for isolating strains with high thermotolerance. The isolated clones showed growth improvement at both high temperatures and ethanol concentration by drop tests. Among all, the PAB1 S40.7 variant was further characterized because, strikingly, it dominantly confers higher thermotolerance by expressing just the first 20 amino acidic residues of Pab1. This improved phenotype was also confirmed in bioreactor at 40°C. Remarkably, the S40.7 strain accumulates less ROS compared to the control strain, thus possibly explaining its increased thermotolerance. Overall, these results demonstrated that Pab1 is a powerful candidate to evoke complex phenotypes with improved traits, among which higher thermotolerance. Finally, Pab1 was characterized to uncover the role of its domains in the recruitment of the protein within stress granules, aggregates of untranslated mRNPs that form during stressful conditions. This characterization shows that Pab1 association into these aggregates relies mainly on RNA recognition motives, RRM, whose number is important for an efficient recruitment. Although the P and C domains do not directly participate in Pab1 association to stress granules, their presence strengthens or decreases, respectively, the distribution of synthetic Pab1 variants lacking at least one RRM into these aggregates. As additional outcome, this part of the work is suggesting that Pab1 domains might be rationally exploited for synthetic biology purposes. Overall, the results of this thesis highlight and confirm the difficulty but at the same time the power of cellular rewiring in evoking industrially relevant phenotype. Pab1 is undoubtedly emerging as a pivotal element that deserves more attention for future strain design and tailoring.
Costa, Liliana Maria. « Analysis of the effects of the globby1-1 (glo1-1) mutation on maize seed development ». Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434854.
Texte intégralBaptista, Marcella Bergamini de 1988. « Análise de mutações no gene GLB1 em pacientes com gangliosidose GM1 formas juvenil e crônica ». [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308543.
Texte intégralDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Gangliosidose GM1 é uma doença autossômica recessiva rara, classificada em três formas clínicas de acordo com a idade de apresentação dos sintomas e a gravidade, provocada pela deficiência da enzima lisossômica ?-galactosidase que leva ao acúmulo, principalmente, do gangliosídeo GM1. A forma juvenil geralmente apresenta início entre sete meses e três anos de idade, com progressão lenta dos sinais neurológicos, dimorfismos menos graves que na forma infantil e deformidades ósseas. A forma crônica é caracterizada por apresentações clínicas mais leves e sintomas extrapiramidais. O gene codificador da enzima é o GLB1, no qual mais de 130 mutações foram descritas. No presente estudo foi realizada a caracterização molecular de 10 indivíduos de nove famílias não relacionadas diagnosticados com gangliosidose GM1, nas formas juvenil e crônica. Todas as famílias são originárias do interior do estado de São Paulo ou do sul do estado de Minas Gerais. Para a análise realizada foi possível identificar a mutação anteriormente descrita p.T500A, em sete das nove famílias estudadas, a inserção c.1717- 1722insG e a mutação p.R59H foram encontradas em duas famílias (a última segregou juntamente com o polimorfismo descrito IVS12+8T>C). As demais mutações descritas (p.F107L, p.L173P, p.R201H, p.G311R) foram encontradas em uma família cada. Uma alteração neutra (p.P152P) e duas mutações (p.I354S e p.T384S) são inéditas. Foi possível identificar a ocorrência de uma mutação de novo em uma família. Todas as mutações foram encontradas em heterozigose
Abstract: GM1 gangliosidosis is a rare autosomal recessive, classified in three clinical types according to age of onset and severity. The disease is caused by the deficiency of lysosomal enzyme ?-galactosidase that leads to the accumulation of GM1 ganglioside. The juvenile form usually shows an onset between seven months and three years of age, with slowly progressive neurological signs, less severe dysmorphisms than the infantile form and skeletal changes. The adult form is specified by a milder clinical manifestations and extrapyramidal signs. The lysossomal enzyme is coded by the GLB1 gene which more than 130 mutations have been decribed. In the present study it was genotyped 10 individuals of nine unrelated families originated from the States of São Paulo and Minas Gerais diagnosed with the juvenile and chronic forms of the disease. It was possible to find the previously described mutations p.T500A in seven of the nine families, c.1717-1722insG and p.R59H in two alleles (the latter also segregating with IVS12+8T>C), and p.F107L, p.L173P, p.R201H, and p.G311R in one familie each. One neutral alteration (p.P152P) and two mutations (p.I354S and p.T384S) are described for the first time. The occurrence of a de novo mutation was seen in one family. All patients presented as heterozygous compound
Mestrado
Ciencias Biomedicas
Mestra em Ciências Médicas
Radil, Přemek. « Implementace algoritmu LoD terénu ». Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2012. http://www.nusl.cz/ntk/nusl-236448.
Texte intégralMariana, de Medeiros Nóbrega Elisa. « Histórias de confissões e de leituras : a emergência Histórica da edições GLS ». Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/7231.
Texte intégralEste trabalho procura mapear as condições históricas que viabilizaram a invenção da literatura gls, estabelecendo uma relação entre política e texto, por entender que a produção da Edições GLS está inserida no contexto relacional entre o movimento político de afirmação homossexual e a produção de novos códigos culturais de representação identitária. Para tanto, se faz necessário cartografar a irrupção, no presente, de uma política positiva da visibilidade - como nomeada pelos grupos de ativismo gay e divulgada pela Edições GLS - , que postula a publicização, a confissão e a proliferação de discursos para a formulação de uma identidade cultural, demarcada pela orientação sexual, ao problematizar as estratégias políticas utilizadas pelos militantes gays e as imbricações com a promoção de uma literatura confessional, que solicita, através de práticas editoriais e literárias, o direito de ser/estar na história e o direito de produzir suas próprias referências culturais. Nesse intuito, desenvolvemos um campo de reflexão epistemológica do ofício historiográfico relativo à historicidade do tempo presente, problematizando como a história da leitura e a emergência de novas culturas do escrito estão implicadas num debate contemporâneo sobre a promoção de novos modos de leitura e de leitores, assim como na invenção da literatura gls
Hein, Charlotte Barbara. « Expression der Glutamattransporter GLT1 und GLAST im Gyrus dentatus der Ratte nach Läsion der Regio entorhinalis ». [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=968413188.
Texte intégralKherbouche, Farid. « Le néolithique tellien de la grotte de Gueldaman GLD1 (Babors d'Akbou, Algérie, VIII-V millénaire BP) ». Thesis, Toulouse 2, 2015. http://www.theses.fr/2015TOU20116/document.
Texte intégralA multidisciplinary project at GLD1 cave in the Adrar Gueldaman ridge (Babors near Akbou/North Algeria) was initiated by CNRPAH in 2010. A Neolithic sequence covering the VIII-V millennia BP has been revealed (Sectors S2 and S3). The chronostratigraphic, climatic, economic and cultural contexts have been studied, leading to the definition of four archaeological units chronologically delimited using 28 14C dates on charcoal (cal BP): UA1 [7200-6500], UA2 [6500-530], UA3 [5000-4600], UA4 [4500-4200]. The paleoclimate for periods UA2 to UA4 was reconstructed using isotopic analysis (d13C and d18O) of two stalagmites (STM2 and STM4), demonstrating a correlation between climatic changes and the occupation of the cave. A prolonged drought at ca. 4400–3800 cal BP is supposed to be the responsible of cave abandonment shortly after ca. 4403 cal BP. The domestic fauna is composed of sheep and goat (UA1) and cattle (UA2). The slaughter profiles for the ovis/capra assemblages suggest a mixed meat/milk economy. Molecular and isotopic analysis of absorbed food residues from 140 pottery vessels confirms the exploitation of domesticated animals, for their carcass fats and their secondary products, e.g. dairy fats. Preliminary palaeobotanical results (10% of the remains studied) show that both wheat and barley were cultivated during the last unit (UA4). Vessels with conical bottoms were decorated by incision (UA1) or impression techniques without using cardium shell. Lithic tools have epipalaeolithic characteristics, but typical Neolithic ones such as arrowheads, scrapers, and saws are also present. The worked bone industry is exceptionally rich, diversified and well preserved. A large variety of well-preserved ornaments were crafted from elephant ivory, marine gastropod shells, bird bones, tortoise shells, and ostrich eggshell
Kherbouche, Farid. « Le néolithique tellien de la grotte de Gueldaman GLD1 (Babors d'Akbou, Algérie, VIII-V millénaire BP) ». Electronic Thesis or Diss., Toulouse 2, 2015. http://www.theses.fr/2015TOU20116.
Texte intégralA multidisciplinary project at GLD1 cave in the Adrar Gueldaman ridge (Babors near Akbou/North Algeria) was initiated by CNRPAH in 2010. A Neolithic sequence covering the VIII-V millennia BP has been revealed (Sectors S2 and S3). The chronostratigraphic, climatic, economic and cultural contexts have been studied, leading to the definition of four archaeological units chronologically delimited using 28 14C dates on charcoal (cal BP): UA1 [7200-6500], UA2 [6500-530], UA3 [5000-4600], UA4 [4500-4200]. The paleoclimate for periods UA2 to UA4 was reconstructed using isotopic analysis (d13C and d18O) of two stalagmites (STM2 and STM4), demonstrating a correlation between climatic changes and the occupation of the cave. A prolonged drought at ca. 4400–3800 cal BP is supposed to be the responsible of cave abandonment shortly after ca. 4403 cal BP. The domestic fauna is composed of sheep and goat (UA1) and cattle (UA2). The slaughter profiles for the ovis/capra assemblages suggest a mixed meat/milk economy. Molecular and isotopic analysis of absorbed food residues from 140 pottery vessels confirms the exploitation of domesticated animals, for their carcass fats and their secondary products, e.g. dairy fats. Preliminary palaeobotanical results (10% of the remains studied) show that both wheat and barley were cultivated during the last unit (UA4). Vessels with conical bottoms were decorated by incision (UA1) or impression techniques without using cardium shell. Lithic tools have epipalaeolithic characteristics, but typical Neolithic ones such as arrowheads, scrapers, and saws are also present. The worked bone industry is exceptionally rich, diversified and well preserved. A large variety of well-preserved ornaments were crafted from elephant ivory, marine gastropod shells, bird bones, tortoise shells, and ostrich eggshell
SOUZA, Luiz Henrique Braúna Lopes de. « Festa no gueto ? Memórias e discursos em torno do “mercado GLS” em Recife/PE ». Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/19014.
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FACEPE
O presente trabalho tem o objetivo geral de analisar os sentidos produzidos acerca dos acordos e tensões entre o mercado e sociabilidade voltados a lésbicas, gays, bissexuais, travestis e transexuais (LGBT), tendo como referência as trajetórias de conformação recente dos espaços de consumo, lazer e sociabilidade, que se definem como GLS (Gays, Lésbicas e Simpatizantes), localizados no centro da cidade do Recife/Pernambuco. Para tanto, buscamos, a partir de diálogos com interlocutoras privilegiadas: 1) construir as narrativas das histórias de conformação dos atuais espaços de consumo, lazer e sociabilidade GLS do Recife; 2) problematizar os acordos e tensões entre mercado, sociabilidade e agenciamentos políticos voltadas à população LGBT. Esta pesquisa partiu de uma abordagem psicossocial, na interface com estudos em gênero e sexualidade, à luz da perspectiva crítica feminista. Definimos como estratégia teórico-metodológica para produção de informações, a entrevista semiestruturada, compreendendo-a como práticas discursivas, em consonância com a perspectiva construcionista de produção do conhecimento. Portanto, realizamos as entrevistas com as interlocutoras privilegiadas dos espaços de sociabilidade estudados, definidas a partir dos critérios de tempo, convívio e responsabilidade em relação a esses lugares. Como resultados, construímos as narrativas de como surgiram os espaços de consumo, lazer e sociabilidade destinados à população LGBT que atualmente compõem o circuito GLS da cidade do Recife (Boate MKB, Clube Metrópole, Nosso Jeito Music, Castelo Marron, Confraria Ursos de Pernambuco, Conchittas Bar e Mix Pub). Em nossas análises, também abordamos os acordos e tensões entre mercado e sociabilidade, a partir de três eixos temáticos e seus respectivos tópicos analíticos, com a finalidade de compreender os sentidos coproduzidos sobre essas temáticas: Lazer e Sociabilidade (Motivação, Público e Práticas Sexuais), Mercado (Resistências, Localização, Concorrência, Aspectos Positivos e Negativos, e Legislação) e Agenciamentos políticos (Movimento LGBT e Parada da Diversidade).
The general objective of this study is to analyze the meanings produced about the agreements and disagreements between the market and sociability focused on at lesbians, gays, bisexuals and transgenders (LGBT), taking as reference the recent forming trajectories of consumption, leisure and sociability spaces, wich are defined by the term GLS (gays, lesbian and sympathizers), located in Recife's downtown, Pernambuco. To this end, we seek to, in a dialogue with privileged interlocutors: 1) build the narrative of forming trajectories of current of consumption, leisure and sociability spaces of the GLS market; 2) discuss the agreements and disagreements between market, sociability and political agencies focused on LGBT people. This research is based on a psychosocial approach in dialogue with gender and sexuality studies in the light of critical feminist perspective. The semi-structured intervier was defined as the theoretical and methodological strategy for the production of information, understanding it as a discursive practice, in line with the constructionist perspective of knowledge production. Therefore, we conducted interviews with privileged interlocutors from sociability spaces where the study take place, chosen by the criterion of time, familiarity and responsability concerning these places. As a result, we construct narratives about how arose the consumption, leisure and sociability spaces for the LGBT people that currently make up the GLS market of Recife (Boate MKB, Clube Metrópole, Nosso Jeito Music, Castelo Marron, Confraria Ursos de Pernambuco, Conchittas Bar and Mix Pub). In our analysis, in order to understand the co-produced meanings about these issues, we discuss the agreements and disagreements between market and sociability based on three main themes and their analytical topics: Leisure and Sociability (Motivation, Public and Sexual Practices), Market (Resistences, Location, Competition, Positives and negatives aspects, and law) and Political Agencies (LGBT Movement, Diversity Pride Parade).
Appleby, Vanessa Jane. « The role of the zinc-finger genes Ru49/Zipro1 and Gli1 in granule cell development and tumorigenesis ». Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272576.
Texte intégralRibeiro, Andressa de Freitas. « Da Avenida Cerqueira Lima ao Beco dos Artistas : um espaço de sociabilidade GLS ». reponame:Repositório Institucional da UFBA, 2011. http://www.repositorio.ufba.br/ri/handle/ri/12778.
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Capes
Este trabalho se propõe a pensar um espaço de sociabilidade homossexual em Salvador, o Beco dos Artistas, refletindo sobre como as pessoas vivem esse espaço, o significado e sentido que lhe atribuem, e sobre as práticas, relações e comportamentos que se dão espaço à dentro. Proponho-me a pensar, também, os motivos da existência de tal espaço e quais as consequências de sua existência tanto para os frequentadores, quanto para o tecido social de forma mais ampla. Para isso, realizo uma etnografia sobre o espaço, descrevo suas características físicas e sociais, sempre com o intuito de utilizar essa descrição como material para reflexões de cunho mais crítico e teórico, tentando sempre perceber quais as questões sociais que aquele espaço particular suscita. Com essa perspectiva, a discussão sobre espaço e sexualidade ganhou um lugar central no meu trabalho. This paper proposes to consider a space of homosexual sociability in Salvador, Beco dos Artistas, reflecting about how people live in this space, the meaning and sense which they attribute to it, and their practices, relations and attitudes. I also propose a reflection on the reasons for the existence of such place and the consequences of its existence, for both the visitors and the wider society. In view of those questions, I do an ethnography of the space, describe its physical and social characteristics, in order to use these data as a material for critical and theoretical reflections, trying to realize what are the social issues raised by that particular space. Therefore, the discussion on space and sexuality takes a central place in this work.
Salvador
Moretti, S. « MODULATION OF GLUTAMATE TRANSPORTER 1 (GLT1) FUNCTION AND EXPRESSION IN ISLETS OF LANGERHANS : PHYSIOLOGICAL ROLE AND PATHOLOGICAL IMPLICATIONS ». Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/335079.
Texte intégralPonomareva, Ekaterina. « Effects of Different Signalling Pathways on Regulation of 'GLK' GARP Transcription Factors in 'Arabidopsis thaliana' ». Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22726.
Texte intégralAndersson, Jonas, et David Karlsson. « Improving rendering times of Autodesk Maya Fluids using the GPU ». Thesis, Linköping University, Visual Information Technology and Applications (VITA), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50709.
Texte intégralFluid simulation is today a hot topic in computer graphics. New highly optimized algorithms have allowed complex systems to be simulated in high speed. This master thesis describes how the graphics processing unit, found in most computer workstations, can be used to optimize the rendering of volumetric fluids. The main aim of the work has been to develop a software that is capable of rendering fluids in high quality and with high performance using OpenGL. The software was developed at Filmgate, a digital effects company in Göteborg, and much time was spent making the interface and the workflow easy to use for people familiar with Autodesk Maya. The project resulted in a standalone rendering application, together with a set of plugins to exchange data between Maya and our renderer.
Most of the goals have been reached when it comes to rendering features. The performance bottleneck turned out to be reading data from disc and this is an area suitable for future development of the software.
França, Isadora Lins. « Cercas e pontes : o movimento GLBT e o mercado GLS na cidade de São Paulo ». Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/8/8134/tde-03092007-141155/.
Texte intégralThis thesis is a study of the GLBT (Gay, Lesbian, Bisexual and Transgender) movement and its relations with a segmented market that is focused on homosexuals or GLS (Gay, Lesbian and Supporter). This work departing from the conducted field research on the Associação da Parada do Orgulho GLBT de São Paulo (APOGLBT - São Paulo\'s Association for the GLBT Pride Parade) seeks to understand these relations. Besides this, an effort has been made to understand the dynamics of the GLS market and the GLBT movement, specially in São Paulo, since the mid 1990s. The focus of this thesis is grounded on an analysis of processes of rapprochement and differentiation between the movement and the market, involving situations of conflict and collaboration between both social actors. This approach has been elaborated from a theoretical discussion about processes of collective identity formation, present in the constitution of political subjects, as well as from an anthropological perspective on consumption processes.
Setterberg, Joel, et Jonatan Elsgard. « IMPLEMENTERING AV PHONGLJUSSÄTTNINGI 2D-SPELMILJÖ ». Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-36140.
Texte intégralIn recent years, a new trend in the gaming industry has emerged since a large part of the games have gone back to the two-dimensional environments that were more common in the early days of the video games history . This is due to mobile phones and their games have taken more and more space on the market and they are often two-dimensional because of the limited harware. The twodimensional games have traditionally never had any dynamic lighting , they have consisted of premade graphics with predetermined intensities , which means that the games may look flat. But in other areas within the gaming industry, especially three-dimensional games, the evolution of dynamic lighting techniques have come a long way. The problem with these methods is that they require the object's normals, which are not normally available in two-dimensional images. Today mobile phones are powerful and capable of much heavier computations than they did just a few years ago. Therefore, we examined the possibility of implementing dynamic lighting in a twodimensional games on Androidbased mobile phones. To accomplish this it required that we investigated methods to generate normals for two-dimensional graphics. In order to create a full game we also implemented features such as collision handling, artificial intelligence and procedural generation of maps.
Qrunfleh, Abeer Mostafa. « Activation of Glutamate Transporter 1 Attenuates Relapse to Alcohol-Seeking Behavior in Rats ». University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1333557399.
Texte intégralHakami, Alqassem Yahia I. « Effects of ß-lactam Compounds on GLT1 and xCT Expression levels as well as Ethanol Intake in Alcohol-Preferring Rats ». University of Toledo Health Science Campus / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=mco1437429337.
Texte intégralBensalma, Souheyla. « Voie Hedgehog et système VIP-récepteurs dans des cellules de glioblastome ». Thesis, Poitiers, 2013. http://www.theses.fr/2013POIT2317/document.
Texte intégralThe most aggressive form of glioma, primary brain tumors, is grade IV astrocytoma also called glioblastoma (GBM)
Kissling, Ramon. « Nachhaltigkeit in der Finanzdienstleistungsbranche Drei Fallstudien mit konstruktivistischem Zugang zur Nachhaltigkeitsrationalität der Banken ABS, GLS, Sarasin / ». St. Gallen, 2007. http://www.biblio.unisg.ch/org/biblio/edoc.nsf/wwwDisplayIdentifier/04603841001/$FILE/04603841001.pdf.
Texte intégralBlackburn, Nicholas. « The AGE of Biomaterials : Preserving the Myocardium after Infarction to Promote Heart Repair and Function ». Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36371.
Texte intégralCAIRANO, E. S. DI. « GLUTAMATE TRANSPORTERS IN PANCREAS AND EPITHELIA : PHYSIOLOGICAL ROLES AND DYNAMIC REGULATION ». Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150106.
Texte intégralAndersson, Nyberg Sarah, et Martina Lesjak. « Jämförelse mellan ekokardiografiska metoder vid bedömning av vänsterkammarfunktion hos kvinnliga bröstcancerpatienter ». Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för naturvetenskap och biomedicin, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-26955.
Texte intégralEchocardiography is a useful technique which can value the function of the left chamber of the heart by using ejection fraction (EF) and global longitudinal strain (GLS). Today EF is the most common method in assessments of the left chamber function and is calculated by Simpson´s biplanemethod. GLS is a new method that measures the myocardial deformation. It has been proved to be a sensitive method and can detect changes in the myocardium earlier than EF. The purpose of this study is to compare two echocardiographic methods among 20 female breast cancer patients. Comparisons have been made between EF calculated with Simpson´s biplanemethod (EFbi) and GLS, and between EFbi and EF calculated by GLS (EFGLS). This is a quantitative retrospective study. The data used in this study was collected between October – December 2014 at the Department of Clinical Physiology at the Hospital Ryhov in Jönköping. The method used to analyse the results was McNemar´s test and Kappa value. The results of the study showed that EFbi and GLS gave a modest correspondence between the methods. A reasonable correspondence were observed between EFbi and EFGLS. The conclusion has been drawn from the kappa value.
Oliveira, Esmael Alves de. « Nas fronteiras da sexualidade : uma análise sobre os processos de construção e apropriação do espaço em boates GLS do centro da cidade de Manaus ». Universidade Federal do Amazonas, 2009. http://tede.ufam.edu.br/handle/tede/3914.
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CNPQ - Conselho Nacional de Desenvolvimento Científico e Tecnológico
Le présent document se tourne vers l'analyse des processus de construction et d'appropriation de GLS discothèques espace dans le centre de Manaus. En ce sens, soulève des questions sur les différentes représentations des différents acteurs sociaux sur ces domaines et en même temps, réfléchit sur les différentes significations qui passent par une GLS discothèque. La coupure était le territoire et de représentation, où nous pensons que la relation entre l'espace, la stigmatisation et la résistance symbolique, notant que pour la dimension politique de la sociabilité.
O presente trabalho volta-se para a análise sobre os processos de construção e apropriação do espaço em boates GLS do centro de Manaus. Neste sentido, busca problematizar acerca das diferentes representações que os vários agentes sociais possuem sobre estes espaços e ao mesmo tempo busca refletir sobre os diferentes significados que perpassam uma boate GLS. O recorte utilizado foi o de território e representação, onde buscamos pensar a relação entre espaço, estigmatização e resistência simbólica, destacando para isso a dimensão política e a de sociabilidade.
Bertolacini, Cláudia Danielli Pereira [UNESP]. « Análise dos genes GL1 E PTCH1 em indivíduos com anomalias craniofaciais de linha média, olho e face ». Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/102675.
Texte intégralCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Classificada como a quarta anomalia congênita mais frequente em recém-nascidos, as anomalias craniofaciais constituem um grupo diverso e complexo, determinando, na maioria das vezes aos seus portadores, um prognóstico reservado. Dentre as alterações craniofaciais destacam-se aquelas que ocorrem em função de alterações no desenvolvimento da linha média craniofacial. Alguns estudos genéticos mostram o envolvimento de vários genes durante os diferentes processos de desenvolvimento craniofacial. O gene Sonic Hedgehog (SHH) é expresso durante o desenvolvimento normal dos tecidos da linha média facial. Alguns estudos relatam a atividade da via sinalizadora do gene SHH na formação craniofacial, especialmente sua influência sobre os defeitos de linha média. Os genes mais conhecidos relacionados à rede sinalizadora do SHH compreendem, além do SHH, os genes ZIC2, TGIF, PTCH1, GLI2, FAST1, TDGIF, SUFU e o DHCRT. O objetivo desse trabalho foi realizar a análise de mutações nos genes GLI2 e PTCH1, através do sequenciamento direto, em 110 indivíduos com anomalias craniofaciais de linha média, olho e face, previamente analisados para os genes SHH, TGIF e SIX3. Os resultados obtidos pelo sequenciamento do gene GLI2 mostraram a presença de quatorze variações em regiões codificadoras, em 14 indivíduos brasileiros sem parentesco: 1 deleção, 1 inserção, 9 variantes não sinônimas e 3 variantes sinônimas. Nenhuma dessas variações foram encontradas nos 96 controles brasileiros normais. Seis dos quatorze indivíduos apresentavam manifestações fenotípicas que variavam de fissura de lábio/palato isolada com polidactilia, anomalia de arco branquial a Holoprosencefalia (HPE) semi-lobar. Novas variantes foram encontradas nesse gene em pacientes com comprometimento na junção temporomandibular (ATM), um novo achado...
Classified as the fourth most frequent congenital anomaly in newborns, the craniofacial anomalies occupy a wide and complex group, setting in the most of its carriers, a reserved prognosis. Some genetics studies show the involvement of several genes during different processes of craniofacial development. The Sonic Hedgehog gene (SHH) is expressed during the normal development of the midline facial tissues. Some of the studies reveals the activity of the signaling pathway of the SHH in the craniofacial formation, specially on its influence on the defects in the midline. The most known genes related to the SHH signaling pathway include, ZIC2, TGIF, PTCH1, GLI2, FAST1, TDGIF, SUFU and DHCRT, besides SHH. The main purpose of this work was to analyze the mutations in the GLI2 and PTCH1 genes, through direct sequencing, in 110 individuals with midline craniofacial anomalies, previously screened for SHH, TGIF and SIX3 genes. The results obtained by direct sequencing of GLI2 gene show the presence of 14 variations in coding region, in 14 unrelated Brazilian individuals: 1 deletion, 1 insertion, 9 no synonymous variants and 3 synonymous variant. None of these variations were found in the 96 Brazilian control individuals. Six of the fourteen individuals had phenotypic manifestations that varied from isolated lip/palate cleft with polydactyly, branchial arch anomalies to semi-lobar Holoprosencephaly (HPE). New variants were found in this gene in patients with temporomandibular joint commitment, a new clinical finding noted in GLI2 mutation. The analysis of PTCH1 gene shows the presence of seven new variants in 14 unrelated Brazilian individuals: 4 in intragenic regions and 3 in splicing regions. None of these variations were found in the 96 Brazilian control group. The duplication of 18pb, found on intron 1 in 7 individuals with HPE, took attention and... (Complete abstract click electronic access below)
Bertolacini, Cláudia Danielli Pereira. « Análise dos genes GL1 E PTCH1 em indivíduos com anomalias craniofaciais de linha média, olho e face / ». Botucatu, 2012. http://hdl.handle.net/11449/102675.
Texte intégralBanca: Danilo Moretti-Ferreria
Banca: Nádia Bérgamo
Banca: Narciso Vieira
Banca: Rosangela Vieira de Andrade
Resumo: Classificada como a quarta anomalia congênita mais frequente em recém-nascidos, as anomalias craniofaciais constituem um grupo diverso e complexo, determinando, na maioria das vezes aos seus portadores, um prognóstico reservado. Dentre as alterações craniofaciais destacam-se aquelas que ocorrem em função de alterações no desenvolvimento da linha média craniofacial. Alguns estudos genéticos mostram o envolvimento de vários genes durante os diferentes processos de desenvolvimento craniofacial. O gene Sonic Hedgehog (SHH) é expresso durante o desenvolvimento normal dos tecidos da linha média facial. Alguns estudos relatam a atividade da via sinalizadora do gene SHH na formação craniofacial, especialmente sua influência sobre os defeitos de linha média. Os genes mais conhecidos relacionados à rede sinalizadora do SHH compreendem, além do SHH, os genes ZIC2, TGIF, PTCH1, GLI2, FAST1, TDGIF, SUFU e o DHCRT. O objetivo desse trabalho foi realizar a análise de mutações nos genes GLI2 e PTCH1, através do sequenciamento direto, em 110 indivíduos com anomalias craniofaciais de linha média, olho e face, previamente analisados para os genes SHH, TGIF e SIX3. Os resultados obtidos pelo sequenciamento do gene GLI2 mostraram a presença de quatorze variações em regiões codificadoras, em 14 indivíduos brasileiros sem parentesco: 1 deleção, 1 inserção, 9 variantes não sinônimas e 3 variantes sinônimas. Nenhuma dessas variações foram encontradas nos 96 controles brasileiros normais. Seis dos quatorze indivíduos apresentavam manifestações fenotípicas que variavam de fissura de lábio/palato isolada com polidactilia, anomalia de arco branquial a Holoprosencefalia (HPE) semi-lobar. Novas variantes foram encontradas nesse gene em pacientes com comprometimento na junção temporomandibular (ATM), um novo achado... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Classified as the fourth most frequent congenital anomaly in newborns, the craniofacial anomalies occupy a wide and complex group, setting in the most of its carriers, a reserved prognosis. Some genetics studies show the involvement of several genes during different processes of craniofacial development. The Sonic Hedgehog gene (SHH) is expressed during the normal development of the midline facial tissues. Some of the studies reveals the activity of the signaling pathway of the SHH in the craniofacial formation, specially on its influence on the defects in the midline. The most known genes related to the SHH signaling pathway include, ZIC2, TGIF, PTCH1, GLI2, FAST1, TDGIF, SUFU and DHCRT, besides SHH. The main purpose of this work was to analyze the mutations in the GLI2 and PTCH1 genes, through direct sequencing, in 110 individuals with midline craniofacial anomalies, previously screened for SHH, TGIF and SIX3 genes. The results obtained by direct sequencing of GLI2 gene show the presence of 14 variations in coding region, in 14 unrelated Brazilian individuals: 1 deletion, 1 insertion, 9 no synonymous variants and 3 synonymous variant. None of these variations were found in the 96 Brazilian control individuals. Six of the fourteen individuals had phenotypic manifestations that varied from isolated lip/palate cleft with polydactyly, branchial arch anomalies to semi-lobar Holoprosencephaly (HPE). New variants were found in this gene in patients with temporomandibular joint commitment, a new clinical finding noted in GLI2 mutation. The analysis of PTCH1 gene shows the presence of seven new variants in 14 unrelated Brazilian individuals: 4 in intragenic regions and 3 in splicing regions. None of these variations were found in the 96 Brazilian control group. The duplication of 18pb, found on intron 1 in 7 individuals with HPE, took attention and... (Complete abstract click electronic access below)
Doutor
Cabral, Allyson Ney Teodosio. « Visualização da curvatura de objetos implícitos em um sistema extensável ». Universidade Federal de Alagoas, 2010. http://repositorio.ufal.br/handle/riufal/1032.
Texte intégralFundação de Amparo a Pesquisa do Estado de Alagoas
Neste trabalho, estudaremos a visualização da curvatura de superfícies definidas implicitamente por funções do tipo f:[0,1]³ [0,1], usando a técnica de lançamento de raios (ray casting). Como em geral conhecemos apenas valores amostrados de f, estudaremos um método de interpolação tricúbica, a fim de calcular as derivadas de segunda ordem precisamente. A implementação computacional deste trabalho foi desenvolvida na forma de módulos do framework de visualização e processamento de imagens Voreen, o qual se beneficia do poder de processamento das placas gráficas atuais para acelerar o processo de visualização.
Karlsson, Per. « A GPU-based framework for efficient image processing ». Thesis, Linköpings universitet, Medie- och Informationsteknik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-112093.
Texte intégral