Articles de revues : « GlicoproteinaP »

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Bogousslavsky, Julien, Maurizio Paciaroni et Virgilio Gallai. « GLICOPROTEIN (GP) IIb/IIIa INHIBITORS FOR ACUTE STROKE TREATMENT ». Clinical and Experimental Hypertension 24, n^o 7-8 (janvier 2002) : 603–10. http://dx.doi.org/10.1081/ceh-120015336.

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VIDAL, Mônica Scarpelli Martinelli, Selma Aliotti PALACIOS, Natalina TAKAHASHI DE MELO et Carlos da Silva LACAZ. « REACTIVITY OF ANTI-GP43 ANTIBODIES FROM PARACOCCIDIOIDES BRASILIENSIS ANTISERUM WITH EXTRACTS FROM CUTANEOUS LESIONS OF LOBO'S DISEASE : PRELIMINARY NOTE ». Revista do Instituto de Medicina Tropical de São Paulo 39, n^o 1 (janvier 1997) : 35–38. http://dx.doi.org/10.1590/s0036-46651997000100007.

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We demonstrated through several immunochemical tests the presence of GP-43 from P. brasiliensis in extracts of cutaneous lesions from Jorge Lobo's disease. This glicoprotein is one of the immunodominant antigens in this species, and is used to identify it. The demonstration of GP-43 tissues infected by the agent of Jorge Lobo's disease is an additional evidence for classifying it in the genera Paracoccidioides, species loboi

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De Arruda Grossklaus, Daciene, Doracilde Terumi Takahara, Cleoni Silvana Kruger, Andrea Maria Gonzaga, Zoilo Pires de Camargo, Andreia Ferreira Nery, Hugo Luciano Almeida et Rosane Christine Hahn. « PROFILE OF EXOANTIGENS FROM CLINICAL ISOLATES OF Paracoccidioides lutzii IN MATO GROSSO, BRAZIL ». Revista de Patologia Tropical 45, n^o 3 (30 septembre 2016) : 265. http://dx.doi.org/10.5216/rpt.v45i3.43514.

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Este trabalho teve como objetivo determinar o perfil imunoquímico de três exoantígenos, obtidos de amostras clínicas de Paracoccidioides lutzii procedentes do estado de Mato Grosso. Para a obtenção dos exoantígenos, seguiu-se o protocolo padronizado por Camargo et al. e o perfil imunoquímico foi obtido com o emprego da técnica de SDS Page. As frações observadas demonstraram pesos moleculares de 20, 30 e 130 kDa; a glicoproteina de 130 kDa foi evidenciada tendo por base os três exoantígenos utilizados. A detecção desta fração de alto peso molecular sugere um perfil imunoquímico distinto, o que pode contribuir para elucidar as reações falso-negativas obtidas com o antígeno usualmente utilizado (obtido da cepa de referência B-339 de P. brasiliensis). Este achado assume grande importância no sentido de aumentar a especificidade das reações sorológicas utilizadas, para monitorar o prognóstico dos pacientes acometidos pela paracoccidioidomicose.

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Balestrini, R., C. Romera, P. Puigdomenech et P. Bonfante. « Espressione e localizzazione di glicoproteine ricche di idrossiprolina in radici micorrizate di mais ». Giornale botanico italiano 129, n^o 1 (janvier 1995) : 231. http://dx.doi.org/10.1080/11263509509436127.

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Fagliari, J. J., S. L. Silva, P. C. Silva et G. T. Pereira. « Leucograma e teores plasmáticos de proteínas de fase aguda de eqüinos portadores de abdômen agudo e submetidos à laparotomia ». Arquivo Brasileiro de Medicina Veterinária e Zootecnia 60, n^o 2 (avril 2008) : 322–28. http://dx.doi.org/10.1590/s0102-09352008000200007.

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Foram examinados 20 eqüinos adultos portadores de abdômen agudo e submetidos à laparotomia. Dez recuperaram-se sem intercorrência pós-operatória (G1) e 10 foram a óbito sete a 10 dias após a cirurgia, com sinais de choque séptico (G2). Avaliaram-se temperatura retal, freqüências cardíaca e respiratória, tempo de preenchimento capilar e teores plasmáticos das proteínas de fase aguda - fibrinogênio, ceruloplasmina, proteína C-reativa, antitripsina, haptoglobina e glicoproteína ácida -, antes e até sete dias após a laparotomia. As leucometrias às 72h e no sétimo dia pós-operatório dos eqüinos que foram a óbito foram, respectivamente, 34,6% e 57,1%, mais altas que a dos animais curados. Os maiores valores de proteína de fase aguda ocorreram no sétimo dia após a cirurgia; os percentuais de elevação de fibrinogênio, antitripsina, glicoproteina ácida, proteína C-reativa, ceruloplasmina e haptoglobina de eqüinos do G2 em relação ao G1 foram 46,8%, 67,9%, 91,9%, 112,2%, 126,9% e 186,2%, respectivamente.

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Vieira Wanderley, Paula Layana, Carlos Eduardo Tortelli Veloso, Tâmara Vieira Monção et Danille Ferreira de Oliveira. « Avaliação da Alfa-1-Glicoproteína ácida e Mucoproteínas em pacientes com Paracoccidioidomicose tratados com Sulfametoxazol-Trimetoprim ». Saúde Coletiva (Barueri) 11, n^o 67 (2 août 2021) : 6691–704. http://dx.doi.org/10.36489/saudecoletiva.2021v11i67p6691-6704.

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A alfa-1-glicoproteina ácida (AGP) e a mucoproteína são proteínas de fase inflamatória que aumentam suas concentrações plasmáticas quando apresentam um quadro de resposta ao estado inflamatório, representando um mecanismo de defesa do organismo. O objetivo do estudo foi avaliar o perfil dessas proteínas em pacientes com PCM crônica tratados com sulfametoxazol-trimetoprim (SMX-TMP) e associar os resultados encontrados com dados epidemiológicos, fatores de risco, sintomas, evolução da doença, e desfecho do tratamento. Nos métodos adotados foram analisados os prontuários de 244 pacientes com PCM crônica no período de 1998 a 2014. Destes, 134(54,92%) pacientes fizeram exames bioquímicos das proteínas inflamatórias durante o curso da doença. Predominaram pacientes adultos de 30 a 50 anos 73(54,48%), tabagistas 123(91,79%), alcoólicos 60(44,78%). Como resultado obteve-se a diminuição das proteínas inflamatórias após o tratamento (p= 0,01803). Concluindo que a AGP e a mucoproteínas são úteis como marcadores do efeito de terapia e da involução inflamatória.

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Molina, Wilfredo. « Histological Changes of the Mandibular Condyle in the Human Fetus at Early Stages of Gestation ». International Journal of Embryology 2014 (23 février 2014) : 1–8. http://dx.doi.org/10.1155/2014/735949.

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Histochemical studies on the mandibular condyle of the human fetus at gestational ages 12, 14, and 16 weeks were performed. Methods. Histological sections were stained with Schiff’s periodic reaction for glicoproteins, hematoxiline eosine detects mesenchymal tissue and trichhromic stain for collagen. The ANOVA one-way test was used to evaluate the differences during stained zones in the three fetus groups. Results. The percentage of glycoproteins and mesenchymal tissue was denser at 12 weeks. This percentage decreases at 14 weeks and is less at 16 weeks. An increase in the amount of collagen in the studied weeks was observed. The percentages of glycoproteins, mesenchymal tissue, and collagen were significantly different; f = 4373, 9624.8, and 3674, P<0.0001 for the three studied groups. Conclusion. The endochondral bone formation of the mandibular condyle includes modifications of the quantities of glycoproteins, mesenchymal tissue, and collagen.

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Chiavenna, Sebastián M., Agustín Ostachuk, Andrea Pecora, M. Susana Levy, Marina J. Dus Santos et Andrés Wigdorovitz. « Truncated E2 glicoprotein expression in CHO-K1 cells to produce a subunit vaccine against BVDV ». Veterinary Immunology and Immunopathology 128, n^o 1-3 (mars 2009) : 231. http://dx.doi.org/10.1016/j.vetimm.2008.10.047.

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Rachmayanti, Novia. « STRUKTUR PROTEOMIK VIRUS DENGUE DAN MANFAATNYA SEBAGAI TARGET ANTIVIRUS ». Majalah Kedokteran Andalas 37, n^o 2 (3 mai 2015) : 136. http://dx.doi.org/10.22338/mka.v37.i2.p136-142.2014.

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AbstrakVirus dengue (DENV) telah menyebabkan sekitar 50 juta kasus infeksi demam berdarah setiap tahunnya, akan tetapi hingga saat ini belum terdapat vaksin maupun antivirus yang mampu mencegah atau mengobati penyakit tersebut. Selama pengembangan vaksin dan antivirus, diperoleh berbagai informasi tentang struktur protein DENV yang dapat dimanfaatkan sebagai target obat. Makalah membahas tentang struktur proteomik pada DENV, yaitu glikoprotein pada envelope, NS3 protease, NS3 helikase, NS5 metiltransferase, dan NS5 RNA-dependent RNA polimerase.AbstractDengue virus (DENV) has caused over 50 millions infection every year. However, to date neither vaccine nor medicine could be used to prevent or cure the illness. During researches in finding the vaccine or antiviral for DENV, information on DENV protein structure has been obtained which is potentially used as drug target. This paper disscuss DENV proteomic structure that consist of envelope glicoprotein, NS3 protease, NS3 helicase, NS5 methyl-transferase, and NS5 RNA-dependent RNA polymerase.

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LACAZ, Carlos da Silva, Mônica Scarpelli Martinelli VIDAL, Cristiane Neves PEREIRA, Elizabeth Maria HEINS-VACCARI, Natalina Takahashi de MELO, Neusa SAKAI-VALENTE et Giovana Leticia Hernandes ARRIAGADA. « Paracoccidioides cerebriformis Moore, 1935. MYCOLOGIC AND IMMUNOCHEMICAL STUDY ». Revista do Instituto de Medicina Tropical de São Paulo 39, n^o 3 (mai 1997) : 141–44. http://dx.doi.org/10.1590/s0036-46651997000300003.

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The present study concern on mycologic and immunochemical data obtained from two samples of a fungus considered as belonging to the species Paracoccidioides cerebriformis described by Moore in 1935, and maintained since then on Sabouraud’s agar in the mycology collection of the Instituto de Medicina Tropical de São Paulo. After 60 years, the samples exhibited the same characteristics described by Moore (1935). However, experimental lesions did not resulted in guinea-pigs inoculated intratesticularly. The dominant antigen in Paracoccidioides brasiliensis, 43 kDa glicoprotein (gp43), could not be demonstrated by SDS PAGE and Western blotting. Immunoelectrophoresis did not demonstrated the E arch of cathodic migration using a policlonal anti gp43 serum. According to these findings, it is concluded that the fungus described by Moore (1935) as P. cerebriformis does not belong to the genus Paracoccidioides. Paracoccidioidomycosis should therefore be considered as resulting from infection by a single species, Paracoccidioides brasiliensis (Splendore, 1912) as asserted by Almeida (1930). Further studies, through molecular biology methods, could identify the mentioned fungus

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Basta-Jovanovic, Gordana, Sanja Radojevic, Slavisa Djuricic, Marina Savin, Stevo Skodric, Gordana Bunjevacki, Jovan Hadzi-Djokic et Vidosava Nesic. « Adhesion molecules in Wilms tumor (part II) : beta-catenin expression and significance ». Srpski arhiv za celokupno lekarstvo 131, n^o 1-2 (2003) : 73–76. http://dx.doi.org/10.2298/sarh0302073b.

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Beta-catenin is a glicoprotein which has an important role in cell-cell adhesion, as well as in cell signal transmition, in u regulation of gen expression and in interaction with axin and APC (adenomatous poliposis coli). Its oncogenic role in several types of carcinomas in human population is well known. It is very likely that b-catenin as an protooncogen plays an importante role in genesis of Wilms tumor. It is well known that in 15% Wilms tumors there are b-catenin mutations, which indicates that there is a disorder in Wnt signal paththat plays an important role in Wilms tumor genesis. The aim of our study was to investigate b-catenin expression in Wilms tumor, to compaire it with the expression in normal renal tissue as well as to see if there is a positive correlation between b-catenin expression in Wilms tumor with tumor stage, histologic type and/ or prognostic group.

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Battisti, Michelly Kheidy Borges, Daniella Matos da Silva, Mhayara Samile de Oliveira Reusing, Olair Carlos Beltrame, Elizabeth Moreira dos Santos Schmidt, José Jurandir Fagliari, Rosângela Locatelli Dittrich et Simone Domit Guérios. « Proteínas de fase aguda em cadelas com neoplasia mamária ». Ciência Rural 43, n^o 5 (mai 2013) : 902–7. http://dx.doi.org/10.1590/s0103-84782013000500025.

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As proteínas de fase aguda (PFA) apresentam concentrações séricas alteradas mediante processos infecciosos, inflamatórios e neoplásicos. Objetivou-se com este trabalho avaliar as variações séricas das PFA em cadelas portadoras de neoplasia mamária, comparando com a avaliação histológica e leucograma. As PFA foram avaliadas em 45 cadelas com tumor de mama, distribuídas nos grupos neoplasia benigna (n=13), maligna não ulcerada (n=24) e maligna ulcerada (n=8). O grupo controle foi composto por 20 cadelas saudáveis. Foram realizados o teste de eletroforese em gel de poliacrilamida contendo dodecil sulfato de sódio (SDS-PAGE) para identificar as PFA (albumina, ceruloplasmina, transferrina, haptoglobina Hp, α-1 antitripsina e α-1 glicoproteina ácida) e o teste ultrassensível para proteína C reativa (PCR). As pacientes com neoplasia mamária maligna ulcerada apresentaram elevações sérica para PCR e Hp e redução da albumina (P<0,05, One-Way ANOVA e Teste de Dunn). Nessas pacientes, foi observada correlação positiva entre o leucograma inflamatório e o aumento das PFA (P=0,002, Teste de Fisher) e não foram observadas correlações entre as PFA e os subtipos histológicos. Conclui-se que avaliações conjuntas da PCR, Hp e albumina podem ser utilizadas como ferramenta de auxílio diagnóstico e prognóstico em cadelas com neoplasia mamária.

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Baptista, Tiago, Ana Braz, Madalena Patrício, Isabel Fragata et João Reis. « Complicações Tromboembólicas Durante a Terapêutica Endovascular de Aneurismas Rotos Intra-cranianos - Profilaxia e Terapêutica ». Acta Médica Portuguesa 25 (2 novembre 2012) : 25–29. http://dx.doi.org/10.20344/amp.257.

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As complicações tromboembólicas são as mais frequentemente reportadas durante a terapêutica endovascular de aneurismas intracranianos com espiras metálicas. A frequência deste tipo de complicação varia na literatura, contudo autores referem uma incidência entre 2,5 e 28%. Diversos mecanismos poderão estar envolvidos na formação e migração do trombo: pode ser já preexistente no interior do aneurisma a tratar e deslocar-se para o vaso portador; pode formar-se de novo na superfície das espiras ou dos cateteres utilizados; ou ainda no eventual colo residual se o grau de oclusão não for completo. Estudos demonstraram maior incidência de complicações tromboembólicas em aneurismas de colo largo. Neste trabalho discutimos a importância e justificação de medidas utilizadas na prevenção de complicações tromboembólicas durante e após a terapêutica endovascular de aneurismas rotos intra-cranianos. Referem-se ainda as opções e estratégias a adoptar na eventualidade de uma oclusão vascular ser detectada durante o procedimento, como a administração de inibidores da glicoproteina IIb/IIIa ou mesmo a libertação de stents intra-cranianos. Diversos casos exemplificativos são exibidos. A prevenção de complicações tromboembólicas e a rápida actuação perante a oclusão vascular são essenciais para a melhoria do prognóstico dos doentes submetidos a terapêutica endovascular de aneurismas rotos. O conhecimento profundo das opções disponíveis é essencial para a persecução desse objectivo.

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Ferro, D., G. Valesini, A. Tincani, G. Balestrieri, E. Vezza et E. F. Violi. « Anticoagulant activity of anticardiolipin antibodies is blocked by a monoclonal antibody anti-Beta2-glicoprotein I (Beta2-GPI) ». Thrombosis Research 70 (janvier 1993) : S68. http://dx.doi.org/10.1016/0049-3848(93)90384-z.

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Montalvao, Silmara Aparecida De Lima, Priscila Elidio Soares, Sabrina Saraiva, Bruna Moraes Mazetto, Marina Pereira Colella, Erich Vinicius De Paula, Simone Appenzeller, Joyce Maria Annichino-Bizzacchi et Fernanda Andrade Orsi. « Antibodies Directed Against the Domain 1 of Beta2-Glicoprotein 1 May be Associated with Secondary Antiphospholipid Syndrome ». Blood 126, n^o 23 (3 décembre 2015) : 768. http://dx.doi.org/10.1182/blood.v126.23.768.768.

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Abstract Background: The diagnosis of antiphospholipid syndrome (APS) is based on the persistent positivity of lupus anticoagulant (LA), IgM or IgG anticardiolipin (aCL) or IgG anti-β2 glicoprotein 1 (aβ2GP1) antibodies in patients plasma. Particularly, the role of antibodies directed against the domain 1 of β2GP1 (aβ2GP1-D1) has been described as relevant for the mechanism of immunopathogenesis in APS. However, the role of the aβ2GP1-D1 antibodies in clinical diagnosis and management of APS has not been established. Aim: The aim of this study was to evaluated the association of the presence of aβ2GP1-D1 antibodies with the clinical course of patients with thrombotic APS. Patients and methods: Patientspreviously diagnosed with thrombotic APS were consecutively selected for the study, from December 2013 to July 2014, in the Hemostasis Clinic of the Hematology and Hemotherapy Center of the University of Campinas. Demographic features and clinical conditions were recorded at the inclusion and during the follow-up. The clinical parameters analyzed were APS etiology (primary versus secondary to systemic autoimmune diseases), vascular bed of the thrombosis, history of multiple thrombosis, concomitant obstetrical morbidity, the presence of antinuclear antibodies (ANA) and the profile of the antiphospholipid antibodies. Anti-β2GP1-D1 antibodies were determined in patients plasma by chemiluminescence (BioFlash/AcuStar®, Barcelona, ES). Exact Fisher test and logistic regression were performed for statistical analysis. P < 0.05 were considered statistical significant. Results: Eight-five patients were included in the study, all patients presented venous or arterial thrombosis. The antibodies distribution among patients was: 80% LA positive, 50% aCL positive, 54% aβ2GP1 positive and 26% triple positive. Twenty-one patients (25%) tested positive for aβ2GP1-D1, 94% of them had positive aβ2GP1 antibody, previously detected at diagnosis. The presence of aβ2GP1-D1 was not associated with age or gender. Detected clinical conditions related to APS severity, such as thrombosis recurrence, concomitant obstetrical and vascular morbidity and triple positive antiphospholipid antibodies were evaluated. The positivity for aβ2GPI-DI antibodies was not associated with thrombosis recurrence (OR=1.0, 95%CI=0.37-2.71,P=1.0), concomitant obstetrical and vascular morbidity (OR=1.5, 95%CI=0.33-7.34, P=0.58), or triple positive antibodies (OR=2.79 , 95%CI=0.76 - 8.84, P=0.13). Anti-β2GP1-D1 antibodies were associated with the diagnosis of systemic autoimmune disease, in particular with lupus, (OR= 3.49 , 95%CI=1.25-9.76, P=0.01) and with positive ANA test (OR= 3.3, 95%CI=1.08-10.1, P=0.03). Conclusion: In this study, aβ2GPI-DI antibody was detected mainly in patients who had already tested positive for aβ2GP1 antibody, so it is possible that aβ2GP1-D1 assay may not provide additional sensibility to the diagnosis of APS. However, our results also suggested that the presence of aβ2GP1-D1 antibody might be associated to the diagnosis of secondary APS. The diagnosis of primary APS is based on the exclusion of systemic autoimmune diseases and there are no current laboratory parameters that discriminate between primary and secondary APS. Besides the laboratory criteria for lupus diagnosis, there may be overlapping of the antibodies and hematological features between APS and lupus. Furthermore, after the diagnosis of primary APS, it may take long time of follow-up to detect the underlying autoimmune disease. Therefore, if our findings are confirmed, aβ2GP1-D1 assays may play a role as a laboratory tool for the differential diagnosis between primary and secondary APS. Disclosures No relevant conflicts of interest to declare.

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Huaynasi Aguirre, Stefany, Yemima Onque Quirita, Julitza Paredes Fuentes, José Carpio Carpio, José Villanueva Salas, Rita Nieto Montesinos et Karin Vera López. « Desenvolvimiento y validación de métodos bioanalíticos por HPLC- DAD para la cuantificación de fenitoína e inhibidores de la Glicoproteína- P (elacridar y tariquidar) en plasma ». Veritas 21, n^o 1 (20 janvier 2020) : 105. http://dx.doi.org/10.35286/veritas.v21i1.267.

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Se desarrollaron y validaron dos métodos bioanalíticos simples, rápidos, selectivos y sensibles por HPLC-DAD, uno para la determinación y cuantificación de fenitoina, y otro para inhibidores de la Glicoproteina-P (tariquidar y elacridar) usando 0.2ml de plasma. La separación de los analitos se realizó usando columna Chromolith® Performance RP-18 100 - 4.6 mm, con una fase móvil compuesta de ACN:Buffer acetato 10mM pH=5.2 (27.5:72.5) para fenitoina y suEI, para la determinación de tariquidar, elacridar y su EI se usó ACN:MeOH:Buffer acetato 10mM pH=5.2 (30:50:20), en ambos métodos se usó un flujo de 1mL/min, temperatura de 25±1°C, un complemento de honda de 210nm. Los métodos mostraron ser lineales y sensibles, el método fenitoina en el rango de 100 a 50 000 ng/mL (LC = 36.98 ng/mL, LD = 98.79 ng/ mL) e inhibidores de 100 a 20 000 ng/mL (LC = 36.98 ng/mL, LD = 98.79 ng/mL), también mostraron ser precisos (% CV <15), reproducibles y exactos. La recuperación fue superior al 97% (fenitoina) y 93% (inhibidores) ambos métodos presentaron estabilidad en ciclos de congelamiento y descongelamiento, estabilidad a corto (5h y 24h) y a largo plazo hasta por 3 meses a -20 °C. Los métodos bioanalíticos desarrollados y validados podrán servir para evaluar el efecto sobre la farmacocinética y biodisponibilidad de la coadministración de tariquidar y elacridar con fenitoina.

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Morales, Jose, Manuel Serrano, Jose Martinez-Flores, Javier Gainza, Roberto Marcen, Manuel Arias, Fernando Escuin et al. « SO026PRE-TRANSPLANT ANTIBODIES IGA-ANTI-BETA 2 GLICOPROTEIN I : A NEW PREDICTOR OF GRAFT THROMBOSIS AFTER RENAL TRANSPLANTATION ». Nephrology Dialysis Transplantation 32, suppl_3 (1 mai 2017) : iii15. http://dx.doi.org/10.1093/ndt/gfx104.so026.

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Costa, Julia M., J. R. Mineo, J. A. Livramento et M. E. Camargo. « Detecção pelo teste imunoenzimático ELISA de anticorpos IgM anti-Cysticercus cellulosae no líquido cefalorraqueano na neurocisticercose ». Arquivos de Neuro-Psiquiatria 43, n^o 1 (mars 1985) : 22–28. http://dx.doi.org/10.1590/s0004-282x1985000100004.

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Demonstrou-se a presença de anticorpos da classe IgM anti-C. cellulosaeem amostras de LCR de pacientes com neurocisticercose, pelo teste imunoenzimático ELISA. Este foi realizado em placas plásticas sensibilizadas com uma fração glicoproteica de cisticercos. Das 41 amostras de LCR estudadas, 26 pertenciam a pacientes com neurocisticercose, 5 a pacientes com neurossífilis e 10 a pessoas aparentemente normais. Nas 5 amostras de LCR de pacientes com neurossífilis e nas 10 de pessoas aparentemente normais foi negativo o teste ELISA-IgM. Dos 26 LCR de pacientes com neurocisticercose 12 (46,2%) apresentaram anticorpos IgM anti-C. cellulosaecom títulos que variaram de 4 a 32. Essas 12 amostras de LCR quando submetidas ao tratamento com 2-mercaptoetanol tornaram-se negativas no teste ELISA-IgM. Compararam-se os níveis de anticorpos IgM e IgG anti-C. cellulosaedetectados pelos respectivos testes imunoenzimáticos para todas as amostras estudadas e observou-se que, dos 12 LCR de pacientes com neurocisticercose reagentes pelos dois testes, dois apresentaram níveis de IgM mais elevados que de IgG. Paralelamente compararam-se os resultados dos testes ELISA com as reações de fixação do complemento, imunofluorescência e hemaglutinação para neurocisticercose.

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Silva, Alessandra D'Ávila da, Vinícius A. Sortica, Alexandre C. Braga, Fernando R. Spilki, Ana C. Franco, Paulo A. Esteves, Frans Rijsewijk et al. « Caracterização antigênica e molecular de oito amostras do vírus da doença de Aujeszky isoladas no estado do Rio Grande do Sul em 2003 ». Pesquisa Veterinária Brasileira 25, n^o 1 (mars 2005) : 21–24. http://dx.doi.org/10.1590/s0100-736x2005000100005.

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A doença de Aujeszky ou pseudoraiva (DA), causada pelo vírus da pseudoraiva (PRV) é a maior preocupação na produção de suínos. No estado do Rio Grande do Sul, Brasil, a DA foi somente detectada em 1954, em bovino. Em 2003, ocorreram dois surtos de encefalite em granjas na região norte do estado, fronteira com o estado de Santa Catarina. O vírus da doença de Aujeszky (VDA) foi isolado a partir de animais coletados em oito granjas distintas da região e submetido a análises antigênicas e moleculares. As amostras de VDA isoladas foram comparadas com as amostras padrão NIA-3 e NP. A caracterização antigênica dos mesmos foi realizada com testes de imunoperoxidase frente a um painel de anticorpos mono-clonais (Mabs) preparado contra epitopos de glicoproteinas virais (gB, gC, gD e gE). A caracterização genômica foi realizada através da análise restrição enzimática (REA) sobre o genoma total das amostras, com a enzima de restrição (REA) Bam HI. O perfil antigênico das oito amostras isoladas no Rio Grande do Sul, bem como os apresentados pelas amostras padrão NIA-3 e NP, foram similares. A REA revelou que todos as oito amostras do Rio Grande do Sul apresentaram um arranjo genômico do tipo II, genótipo frequentemente encontrado em surtos prévios de DA em outros estados do Brasil. Os resultados aqui obtidos indicam que as oito amostras isoladas no Rio Grande do Sul são similares.

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Antonova, O., D. Pevzner et A. Mazurov. « PHARMACOKINETICS OF F(AB)2 FRAGMENT OF ANTI-GLICOPROTEIN IIb-IIIa MONOCLONAL ANTIBODY FRaMon IN HIGH-RISK CORONARY ANGIOPLASTY ». Journal of Hypertension 22, Suppl. 2 (juin 2004) : S66—S67. http://dx.doi.org/10.1097/00004872-200406002-00226.

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Gamboa-Suasnavart, R. A., L. D. Marín-Palacio, L. López-Griego, M. S. Córdova-Aguilar, N. A. Valdez-Cruz et M. A. Trujillo-Roldán. « VOLUMETRIC POWER INPUT AS A RELIABLE PARAMETER FOR SCALE-UP FROM SHAKE FLASK TO STIRRED-TANK BIOREACTOR : PRODUCTION OF A RECOMBINANT GLYCOPROTEIN BY Streptomyces lividans ». Revista Mexicana de Ingeniería Química 18, n^o 3 (1 juin 2019) : 1085–99. http://dx.doi.org/10.24275/uam/izt/dcbi/revmexingquim/2019v18n3/gamboa.

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Allasia, M., A. Battaglia, E. Garzino, B. Lucatello, A. Notarpietro, G. Mandili, A. Khadjavi et al. « 202 Beta-2-glicoprotein-1 and alpha-1-antitrypsin as urinary prognostic markers of renal cancer in Von Hippel-Lindau patients ». European Urology Supplements 14, n^o 2 (avril 2015) : e202-e202a. http://dx.doi.org/10.1016/s1569-9056(15)60204-4.

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Cano-Mendez, Alan, Nallely García-Larragoiti, Maria Damian-Vazquez, Patricia Guzman-Cancino, Sandra Lopez-Castaneda, Alejandra Ochoa-Zarzosa et Martha Eva Viveros-Sandoval. « Platelet Reactivity and Inflammatory Phenotype Induced by Full-Length Spike SARS-CoV-2 Protein and Its RBD Domain ». International Journal of Molecular Sciences 23, n^o 23 (2 décembre 2022) : 15191. http://dx.doi.org/10.3390/ijms232315191.

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A state of immunothrombosis has been reported in COVID-19. Platelets actively participate in this process. However, little is known about the ability of SARS-CoV-2 virus proteins to induce platelet activity. Platelet-rich plasma (PRP) was incubated with spike full-length protein and the RBD domain in independent assays. We evaluated platelet activation through the expression of P-selectin and activation of glicoprotein IIbIIIa (GP IIbIIIa), determined by flow cytometry and the ability of the proteins to induce platelet aggregation. We determined concentrations of immunothrombotic biomarkers in PRP supernatant treated with the proteins. We determined that the spike full-length proteins and the RBD domain induced an increase in P-selectin expression and GP IIbIIIa activation (p < 0.0001). We observed that the proteins did not induce platelet aggregation, but favored a pro-aggregating state that, in response to minimal doses of collagen, could re-establish the process (p < 0.0001). On the other hand, the viral proteins stimulated the release of interleukin 6, interleukin 8, P-selectin and the soluble fraction of CD40 ligand (sCD40L), molecules that favor an inflammatory state p < 0.05. These results indicate that the spike full-length protein and its RBD domain can induce platelet activation favoring an inflammatory phenotype that might contribute to the development of an immunothrombotic state.

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CALVETE, Juan J., Wolfram SCHAFER, Karlheinz MANN, Agnes HENSCHEN et Jose GONZALEZ-RODRIGUEZ. « Localization of the cross-linking sites of RGD and KQAGDV peptides to the isolated fibrinogen receptor, the human platelet integrin glicoprotein IIb/IIIa. Influence of peptide length ». European Journal of Biochemistry 206, n^o 3 (juin 1992) : 759–65. http://dx.doi.org/10.1111/j.1432-1033.1992.tb16982.x.

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Federici, Augusto B., Luciano Baronciani, Maria T. Canciani, Barbara Moroni, Carlo Balduini, Pier M. Mannucci, Peter J. Lenting et Philip G. de Groot. « Studies with the Nanobody That Detects the Gain-of-Function of von Willebrand Factor in a Cohort of Patients with Type 2B von Willebrand Disease : Correlation with Platelet Count, VWF Multimers and Molecular Defects. » Blood 108, n^o 11 (16 novembre 2006) : 1011. http://dx.doi.org/10.1182/blood.v108.11.1011.1011.

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Abstract Background: Type 2B von Willebrand disease (VWD) is an inherited bleeding disorder caused by abnormal von Willebrand factor (VWF) that displays increased affinity to the platelet glicoprotein 1b alpha (GpIba) and is due to a group of mutations clustered within VWF A1 domain. Such an enhanced 2BVWF-GpIba binding usually result in loss of large VWF multimers and moderate-mild thrombocytopenia. A llama-derived antibody fragment (AuVWFa11) recognizing the GpIba-binding conformation has been recently developed (Blood2005;106:3035). Aims and design of the study: to further explore the usefulness of AuVWFa11 in type 2B diagnosis, we have prospectively tested AuVWFa11 in our cohort of 16 patients previously characterized by platelet count, VWF multimers and mutations. Methods: Data of platelet count with mean platelet volume (MPV) and morphologic evaluation of the blood smear to search for giant platelets or aggregates were associated with the history of physiologic or pathologic stress conditions such as pregnancy, infections, surgery or use of DDAVP. All patients were diagnosed by ristocetin induced platelet agglutination (RIPA) in the Platelet Rich Plasma (PRP), ristocetin cofactor activity (VWF:RCo) with VWF antigen (VWF:Ag), multimeric structure of VWF. Mutations within VWF A1 domain were searched for and confirmed by sequencing exon 28. AuVWFa11 was tested in 40 normal individuals (expressed as % of active VWF in normal pool plasma =0.70±0.13) and in type 2B. Results: Data (mean ± SD) of the AuVWFa11 tested in the 16 patients with type 2B VWD are correlated with the main phenotypic data and genotype (Table1). Platelet count < 140,000 was found at baseline in only 3/16 (%), but was observed after stress conditions in 12/16 cases (%); no reduced platelet counts was found in 4/16 patients (%) from two different families (R1308L, R1341Q). An increased MPV was found in 12 cases but giant platelet and aggregates in only 1 case. Activated VWF as tested by AuVWFa11 was positive in all but 3 (R1308L) cases, with values ranging from 2 to 6 times higher than normal controls: values > 3 correlate with loss of large VWF multimers and mild-moderate thrombocytopenia. Conclusions: The AVWF11a can show activated VWF in most type 2B VWD patients, especially when 2B VWF mutants induce significant loss of large multimers and thrombocytopenia. Therefore AuVWF11a can be a useful additional tool in the diagnosis of type 2B VWD. Table 1 Mutation (n) RIPA (mg/ml) VWF.Ag (U/dL) Plat Count (×10^9/L) MPV (micron^3) Loss of HMW Mult AuVWFa11 (ratioNPP) R1306W (5) 0.65 40±9 165±39 10.3±2.3 YES 3.7±1.5 R1308C (3) 0.72 53±16 163±61 11.5±1.9 YES 3.3±2.3 R1308L (3) 0.50 48±13 341±104 8.1±3.1 NO 0.5±0.2 I1309V (1) 0.40 115 222 11.8 PARTIAL 2.1 V1316M (2) 0.50 32±7 119±30 9.2±2.4 YES 4.4±0.1 P1337L (1) 0.50 48 222 9.5 PARTIAL 1.3 R1341Q (1) 0.67 43 422 9.9 PARTIAL 2.9

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Nazaryan, R., O. Iskorostenskaya, O. Gorenskaya et N. Volkova. « ANALYSIS OF VNTR POLYMORPHISM OF MUC5B GENE IN CONNECTION WITH CERTAIN PHYSICO-CHEMICAL PROPERTIES OF ORAL LIQUID IN CHIL-DREN WITH DOWN SYNDROME ». Inter Collegas 4, n^o 4 (26 décembre 2017) : 211–17. http://dx.doi.org/10.35339/ic.4.4.211-217.

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Protective function of oral fluid is evident in maintaining constant saliva volume, moisturizing mucous membranes of the oral cavity, teeth enamel, preventing the defeat of soft and hard tissues of the oral cavity by pathogenic microorganisms. A number of factors, called "barriers of colonization", specifically and nonspecifically manage the process. What matters most is "mucous block”, which characterizes the set of mechanical, humoral, nonspecific factors of protecting mucous membranes against microorganisms. Mucin proteins which are the main glicoproteine saliva components affect the creation and selection of biofilm microflora, facilitating or inhibiting the adhesion of microorganisms and maintaining healthy microbial environment in the oral cavity. The dominant mucin of submucosa glands is MUC5B, which is encoded by the same gene, located in a short shoulder of segment 15.5 of chromosome 11. Changes of the basic physical and chemical properties of nonstimulated saliva in children with Down syndrome, namely, reduction of pH level and increasing oral fluid viscosity, is certainly an important prerequisite for formation of cariogenic situation.Keywords: Down syndrome, MUC5B, oral cavity, saliva. АНАЛІЗ ПОЛІМОРФІЗМУ VNTR ГЕНУ MUC5B У ЗВ'ЯЗКУ З ДЕЯКИМИ ФІЗІКО-ХІМІЧНИМИ ВЛАСТИВОСТЯМИ РОТОВОЇ РІДИНИ У ДІТЕЙ З СИНДРОМОМ ДАУНА.Назарян Р.С., Іскоростенська О.В., Горенська О.В., Волкова Н.Є. Захисна функція ротової рідини проявляється у підтриманні постійного об'єму слини, зволоженні слизової оболонки ротової порожнини, емалі зубів, запобіганні ураження м'яких і твердих тканин ротової порожнини патогенними мікроорганізмами. Цілий ряд факторів, що їх називають "бар'єрами колонізації", специфічно та неспецифічно керує процесом. Найбільше значення при цьому має "мукозний блок”, який характеризує комплекс механічних, гуморальних, не специфічних факторів захисту слизової оболонки від мікроорганізмів. Білки-муцини, які є основними глікопротеїновими компонентами слини, впливають на створення і вибір мікрофлори біоплівки, полегшуючи або попереджаючи адгезію мікроорганізмів і підтримуючи здорову мікробну середу ротової порожнини. Домінуючим муцином залоз підслизового слою є MUC5B, який кодується однойменним геном, розташованим у короткому плечі сегмента 15.5 хромосоми 11. Зміни основних фізико-хімічних властивостей нестимульованої слини у дітей з діагнозом синдром Дауна, а саме зменшення рівня рН і підвищення рівня плинності ротової рідини, безумовно є важливою передумовою для утворення карієсогенної ситуації.Ключові слова: MUC5B, ротова порожнина, синдром Дауна, слина. АНАЛИЗ ПОЛИМОРФИЗМА VNTR ГЕНА MUC5B В СВЯЗИ С НЕКОТОРЫМИ ФИЗИКО-ХИМИЧЕСКИМИ СВОЙСТВАМИ РОТОВОЙ ЖИДКОСТИ У ДЕТЕЙ С СИНДРОМОМ ДАУНА.Назарян Р.С., Искоростенская О.В., Горенская О.В., Волкова Н.Е. Защитная функция ротовой жидкости проявляется в поддержании постоянного объёма слюны, увлажнении слизистой оболочки полости рта, эмали зубов, предотвращении поражения мягких и твердых тканей ротовой полости патогенными микроорганизмами. Ряд факторов, называемых «барьерами колонизации», специфически и неспецифически управляет данным процессом. Наибольшее значение при этом имеет «мукозный блок», характеризующий комплекс механических, гуморальных, неспецифических факторов защиты слизистой оболочки от заселения ее микроорганизмами. Белки-муцины, которые являются основными гликопротеиновыми компонентами слюны, влияют на создание и выбор микрофлоры биопленки, облегчая или препятствуя адгезии микроорганизмов и поддерживая здоровую микробную среду в полости рта. Доминирующим муцином желез подслизистого слоя является который кодируется одноименным геном, расположенным в коротком плече сегмента 15.5 хромосомы 11. Изменения основных физико-химических свойств нестимулированной слюны у детей с диагнозом синдром Дауна, а именно снижение уровня рН и повышение уровня тягучести ротовой жидкости, является, безусловно, важной предпосылкой для формирования кариесогенной ситуации.Ключевые слова: MUC5B, полость рта, синдром Дауна, слюна.

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Campochiaro, C., A. Tomelleri, R. Ferrara, C. Lazzari, G. De Luca, D. Signorelli, A. Bulotta, V. Gregorc, M. Garassino et L. Dagna. « FRI0478 SEROLOGICAL AUTOIMMUNITY IN PATIENTS WITH RHEUMATIC IMMUNE-RELATED ADVERSE EVENTS : CORRELATION WITH SEVERITY AND TREATMENT ». Annals of the Rheumatic Diseases 79, Suppl 1 (juin 2020) : 836.2–836. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6275.

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Background:Immune checkpoint inhibitors (ICIs) can induce a variety of rheumatic immune-related adverse events (Rh-irAEs). Few data are available on which features can predict the occurrence of long-lasting and severe Rh-irAEObjectives:To describe the serological features associated with long-lasting and severe Rh-irAE.Methods:ICI-treated patients were identified. Patients’ demographics, histotype of cancer, ICI, time interval from ICI start to Rh-irAE onset, characteristics of Rh-irAEs were recorded. Patients were tested for autoimmunity panel (a-IP): RF, ACPA, ANA, anti-SSA, anti-SSB, anti-Sm, anti-RNP, anti-Jo1, ANCA, ASMA, AMA, anti-dsDNA, anti-tireoglobulin, anti-tireoperoxidas, IgM and IgG anti-cardiolipin and anti-β2 glicoprotein I, crioglobulins. All patients were treated with steroids (CS). In case of flare of the Rh-irAE, csDMARDs or bDMARDs were started. Associations between a-IP status and need for DMARD start was evaluated. Non parametric tests were used.Results:22 Rh-irAE were included (see Table 1). Median age at Rh-irAE onset was 70 (50 – 84) years. 2 patients (9%) had a personal history of psoriasis. Median time from ICI start to Rh-irAE onset was 5 (1 – 26) months. 11 patients (50%) developed 1 Rh-irAE, 10 (45.4%) 2 and 1 (4.5%) 3. The most frequent were arthritis (A, 14, 63.6%), cutaneous vasculitis (CV, 5, 22.7%), PMR-like (4, 18.2%), polymyositis (PM, 4, 18.2%), myocarditis (Myo, 3, 13.6%) and dermatomyositis (DM, 2, 9.1%). Median initial prednisone dose was 25 (10 – 75) mg daily. In 14 patients (63.6%) a csDMARD was started upon steroids tapering. 9 patients (41%) were treated with methotrexate (MTX, 4, 18.2%) with hydroxychloroquine (HCQ, 2, 9.1%) with mycophenolate (MMF, 2, 9.1%) with colchicine (colch). 6 patients were treated with bDMARDs. 3 patients (50%) were treated with anakinra (ANK), 2 (33.3%) with IVIG and 3 (50%) with tocilizumab (TCZ). 13 patients (59.1%) were a-IP+. A significantly higher percentage of a-IP+ patients received DMARDs (11, 84.6%) compared to a-IP- patients (2, 22.2%,p = 0.0007). A significantly higher percentage of a-IP+ patients were treated with bDMARDs (5, 38.5%) compared to a-IP- patients (0, 0%, p = 0.05). We analysed whether in csDMARD-treated patients the need for bDMARDs was higher in a-IP+ but we found no statistical significance (45.4% vs 0%, p = 0.487).Table 1.Characteristics and treatment of Rh-irAEs patients.Age, SexCancerICIOnset (monts)Rhem-irAETreatmentResponseICI stopAutoAb169, MLung, adenoNivo3MyoCS, MMF, ANK, TCZLDAY, DpANCA270, MBladderAtezo1A,CS, MTXRemY, TNeg379, MLung SCCPembro1ACSRemNoRo52452, MLung, LCCNivo6A, CVCS, MTX, ANK, TCZLDANoANA 1:160 s582, MLung, LCCPembro3PMRCSRemNoNeg656, MMelanomaPembro26PMR, PMCS, MTXDeathY, DANA 1:160 s, pANCA772, MLung, adenoPembro5A, CVCS, MTX, TCZHDA (TCZ)Y, TANA 1:160 s874, MLung, adenoPembro1PMRCS, MTXLDANoANA 1:160 s975, MLung, adenoPembro1PM, MyoCSRemY, DNeg1075, MLung, adenoNivo9ACSRemNoNeg1168, FLung, adenoAtezo18ACS, MTXLDAY, TNeg1235, MMelanomaNivo2ACS, MTXLDANoANA 1:640 s1379, MLung, SCCNivo15A, PMRCS, MTX, ANKDeath (NR)Y, DRo521477, MLung, adenoPembro8DMCS, HCQ, IVIGLDAY, DANA 1:320 PCNA1567, MLung, adenoNivo13ACS, MTXLDANoASMA1674, MLung, SCCAtezo1A, CVCS, HCQ, ColchLDAY, DNeg1770, MLung, adenoNivo5A, CVCSRemY, DNeg1870, MLung, adenoPembro15ACSLDANoASMA1969, MLung, adenoNivo5DMCS, HCQ, MMF, IVIG, TacroMDAY, TANA 1:!60 s2084, MH&N, SCCNivo3PhCSRemY, DNeg2167, MLung, adenoDurva5A, PM, MyoCSLDAY, DANA 1:160 h2250, FLung, LCCNivo1A, CVCS, HCQRemY, DNegConclusion:The presence of serological autoimmunity might be helpful in detecting patients with Rh-irAEs refractory to steroid therapy.Disclosure of Interests:Corrado Campochiaro Speakers bureau: Novartis, Pfizer, Roche, GSK, SOBI, Alessandro Tomelleri: None declared, Roberto Ferrara: None declared, Chiara Lazzari: None declared, Giacomo De Luca Speakers bureau: SOBI, Novartis, Celgene, Pfizer, MSD, Diego Signorelli: None declared, Alessandra Bulotta: None declared, Vanesa Gregorc: None declared, Marina Garassino: None declared, Lorenzo Dagna Grant/research support from: Abbvie, BMS, Celgene, Janssen, MSD, Mundipharma Pharmaceuticals, Novartis, Pfizer, Roche, SG, SOBI, Consultant of: Abbvie, Amgen, Biogen, BMS, Celltrion, Novartis, Pfizer, Roche, SG, and SOBI

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Miranda, João Luiz de, Dhelfeson Willya Douglas de Oliveira, Rafael Menezes-Silva et Roseana De Almeida Freitas. « Collagen IV and laminin expression in squamous cell carcinomas of lower lip and tongue ». Brazilian Dental Science 19, n^o 2 (7 juillet 2016) : 82. http://dx.doi.org/10.14295/bds.2016.v19i2.1240.

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Objective: In this study, the expression of the extracellular matrix proteins was immunohistochemically studied and compared with the histological grading of squamous cell carcinomas of the lower lip and tongue. Material and Methods: The lower lip carcinomas (n=12) and the tongue carcinomas (n=12) were histopathologically graduated according to Bryne’s method. The immunohistochemical technique utilized specific antibodies to collagen IV and laminin. Histopathologic and immunohistochemical analysis were carried-out on the tumoral invasive front. Results: Most of lower lip carcinomas (91.7%) was classified in lower score and all tongue carcinomas (100%) in high score malignant grade (p<0.01). Collagen type IV expression was absent in the peritumoral basement membrane in 50% of lower lip carcinomas and in 66.7% of tongue carcinomas (p=0.09). Laminin expression was absent in the peritumoral basement membrane in 66.7% of lower lip carcinomas and in 58.3% of tongue carcinomas (p=0.48). When these two glicoproteins were expressed, they showed a linear, thin and discontinuous pattern and a weak intensity of expression. Conclusion: The high score malignancy grade of the tongue carcinomas associated with the expression pattern of the studied matrix proteins. It suggests that tongue squamous cell carcinomas have more invasive potential and more aggressive biological behavior than the lower lip carcinomas. KeywordsCollagen type IV; Laminin; Carcinoma; Immunohistochemistry.

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Santos, Ivan Felismino Charas dos, et Deise Silva Alberto. « PROTEÍNAS DE FASE AGUDA EM CÃES E GATOS ». Arquivos de Ciências Veterinárias e Zoologia da UNIPAR 17, n^o 1 (18 mars 2015). http://dx.doi.org/10.25110/arqvet.v17i1.2014.4918.

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As proteínas de fase aguda (PFA) são um grupo de proteínas sanguíneas que apresentam alterações nas suas concentrações em animais acometidos por infecções, inflamações, trauma cirúrgico ou mesmo submetido ao estresse. São proteínas que alteram as suas concentrações em pelo menos 25% durante a inflamação. As PFA consistem em proteínas de fase aguda negativa e/ou positiva, diminuindo ou aumentando a sua concentração, respectivamente, em resposta a um estímulo inflamatório. Dentre as PFA negativas mais importantes estão a albumina e a transferina. As PFA positivas são a haptoglobina (Hp), proteína C-reativa (CRP), amiloide A-sérico (SAA), ceruloplasmina (Cp), fibrinogênio e a alfa 1 glicoproteina ácida(APG). As avaliações da concentração das PFA e proteínas totais propiciam subsídios para adequada interpretação do estado de hidratação, bem como de inflamação, infecção, doença imunomediada e alteração da síntese proteica. Sendo as PFA mediadores inflamatórios das respostas imunes agudas, e consideradas marcadoras das lesões teciduais na sua fase aguda nos animais, é importante realizar uma revisão sobre as PFA mais importantes e suas funções nos cães e gatos.

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Salas-Asencios, Ramses, José Iannacone-Oliver, Alfredo Guillén-Oneeglio, José Tantaléan-Da Fieno, Lorena Alvariño-Flores, Luz Castañeda-Pérez et Luis Cuellar-Ponce de León. « CORONAVIRUS COVID-19 : CONOCIENDO AL CAUSANTE DE LA PANDEMIA ». Biologist 18, n^o 1 (13 juillet 2020). http://dx.doi.org/10.24039/rtb2020181442.

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El presente artículo presenta una revisión y análisis de las principales investigaciones realizadas sobre el virus SARS-CoV-2 y de la enfermedad que produce (enfermedad por infección por coronavirus, con las siglas en inglés COVID-19). Este virus es conocido de manera coloquial como coronavirus debido a su estructura glicoproteica similar a una corona de puntas, tiene un genoma constituido por una cadena simple de ARN de sentido positivo y es el causante de la actual pandemia iniciada en el 2019 en Wuhan (China) y que viene afectando a más de 199 países o territorios de forma muy relevante. Las semejanzas genéticas de este coronavirus con un virus encontrado en un murciélago, involucran a esta especie como el origen del traspaso al hombre. Si bien este virus ha sido investigado recientemente, ya se conocen sus características morfológicas, estructurales, de replicación, y síntomas. Se ha avanzado en las técnicas de diagnóstico, epidemiología (se describen las fases del desarrollo de la epidemia en el Perú), transmisión, prevención y tratamiento, lo cual se ha consolidado en esta publicación. Considerándose que a la fecha (30.03.20), hay más de 722 mil infectados y han fallecido más de 34 mil pacientes en el mundo (pese a las acciones de aislamiento y distanciamiento social en las que nos encontramos) es eminente la urgente necesidad de desarrollar y usar una vacuna efectiva contra este virus. La OMS (Organización Mundial de la Salud) ha informado que se encuentran en pruebas de fase clínica 44 potenciales vacunas, ello nos podría anunciar la solución relativamente a corto plazo para esta pandemia que en pleno siglo XXI, pretende cambiar nuestras vidas.

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« El factor de necrosis tumoral humano recombinante y la interleukina 1 recombinante alteran la union de Escherichia coli al intestino, a la glicoproteina mucina y a la linea celular intestinal HT29-C1 ». Nutrition 13, n^o 11-12 (novembre 1997) : v. http://dx.doi.org/10.1016/s0899-9007(97)90953-9.

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Articles de revues sur le sujet « GlicoproteinaP »

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