Articles de revues : « Giovanni Colombo »

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Harvey, Giovanni, Gysele Da Silva Colombo Gomes et Suellen Thomaz de Aquino Martins. « CONVERSA ENTRE PRETOS : ENTREVISTA COM GIOVANNI HARVEY / A talk among black : interview with Giovanni Harvey ». Pensares em Revista, n^o 22 (1 octobre 2021) : 8–33. http://dx.doi.org/10.12957/pr.2021.62197.

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Entrevista com o Conselheiro Benemérito do Conselho Municipal dos Direitos dos Negros (COMDEDINE) Giovanni Harvey por Gysele da S. Colombo Gomes e Suellen Thomaz de A. Martins, com questões sobre o tema do dossiê "EDUCAÇÃO ANTIRRACISTA E ENSINO DE LÍNGUAS, LITERATURAS E OUTRAS LINGUAGENS: PESQUISAS E PRÁTICAS"

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Kryvetskyi, V. V., D. V. Proniaiev, T. V. Protsak, B. Y. Banul, N. R. Yemelianenko et V. L. Voloshyn. « History of the development of the lymphatic system (part one) ». Bukovinian Medical Herald 26, n^o 3 (103) (27 octobre 2022) : 73–80. http://dx.doi.org/10.24061/2413-0737.xxvi.3.103.2022.12.

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The history of lymphatic system research goes back to ancient times. Lymph nodes were likely first mentioned in the hieroglyphs of ancient Egypt. Hippocrates (5th century BC) in the 5th century BC was one of the first to mention the lymphatic system. One of the first descriptions of what can be attributed to lymphatic vessels can be found in Aristotle. The Byzantine physician Pavlo Aeginsky was a famous surgeon who illustrated the tonsils and performed the first tonsillectomy, which allowed him to identify and describe infected cervical lymph nodes. Indian and Islamic medicine, especially Avicenna, gave interesting descriptions of lymphedema (elephant disease) due to frequent parasitic infections which are more common in eastern regions. Rufus of Ephesus, a Roman physician, discovered the axillary, inguinal, and mesenteric lymph nodes, as well as the thymus, in the 1st-2nd century AD. The first mention of lymphatic vessels was in the 3rd century BC by Herophilus, a Greek anatomist who lived in Alexandria. The Alexandrian school made significant contributions to the study of the lymphatic system stemming from the works of Galen. However, whether the structures described were lymphatic vessels is still debated. Erasistratus, during the dissection of a dairy lamb, showed that the abdominal arteries are filled with milk. Very likely, this is the first misinterpreted study of mesenteric lymphatic vessels. Based on the first observations made by the medieval Arab anatomist ibn Al-Nafis, the Spanish scientist and theologian Miguel Servetus, and the Italian anatomist Realdo Colombo, who described pulmonary circulation, and Andrea Cesalpino, who first introduced the term "circulation" in relation to the cardiovascular system, it was established basic regularities of the structure of the lymphatic system. In the middle of the 16th century, Gabriele Fallopio (researcher of fallopian tubes) described the vessels now known as "mammary glands". Based on all these discoveries, the Italian surgeon and anatomist Giovanni Guglielmo Riva was the first to present a graphic representation of the lymphatic system in two of his four oil paintings, which are now kept in the Academy of History "Arte Sanitaria" in Rome.

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Muñoz, Rodrigo. « Ugo COLOMBO SACCO DI ALBIANO, Giovanni Paolo II sulla scena del mondo. Magistero sociale, dialogo e diplomazia, Paoline («Saggistica Paoline», 21), Milano 2004, 256 pp., 14 x 21, ISBN 88-315-2601-4. » Scripta Theologica 36, n^o 2 (30 novembre 2017) : 725. http://dx.doi.org/10.15581/006.36.13796.

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Borzi, Cristina, Monica Ganzinelli, Elisa Caiola, Marika Colombo, Giovanni Centonze, Mattia Boeri, Laura Caleca et al. « Abstract 1539 : LKB1 down-modulation by miR-17 biologically and clinically mirrors LKB1-mutated NSCLC ». Cancer Research 82, n^o 12_Supplement (15 juin 2022) : 1539. http://dx.doi.org/10.1158/1538-7445.am2022-1539.

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Abstract Introduction: In non-small cell lung cancer (NSCLC) LKB1 mutations combined with KRAS hyperactivation define a poor responsive, aggressive and disseminating phenotype. We recently unveiled the vulnerability of KRAS/LKB1 co-mutated (KL) patient-derived xenografts (PDXs) to metabolic stress-based treatments, and a clinical trial to test the efficacy of metformin and fasting-mimicking diet on KL NSCLC is currently ongoing in our Institute. Besides inactivating mutations, LKB1 functionality may be impaired by post-translation regulation. Because miR-17 is a potential epigenetic regulator of LKB1,we hypothesized that wild-type LKB1 (LKB1WT) NSCLC with high miR-17 expression may biologically and clinically mirror LKB1 mutated tumors. Methods: NSCLC cell lines with different combinations of KRAS mutation and LKB1 deletion were selected, together with a panel of PDXs with high (LKB1WT/miR-17 high) or low (LKB1WT/miR-17 low) miR-17 expression. Taking advantage of series of NSCLC patients and PDXs, we retrospectively evaluated LKB1 and miR-17 expression levels in tumor tissue specimens. In addition, the TCGA dataset was interrogated for miR-17 expression and potential correlation with lung cancer clinical features. Results: Direct targeting of miR-17 to LKB1 3’UTR was confirmed by luciferase reporter assay. We found that miR-17 overexpression in LKB1WT cell lines functionally impaired the LKB1/AMPK pathway, and prompted apoptotic response to metformin. Of note, LKB1WT/miR-17 high PDXs tumor cells showed a similar behavior upon metformin treatment. A retrospective analysis in patients with NSCLC revealed an inverse correlation between miR-17 and LKB1 expression, and highlighted a prognostic role of miR-17 expression in LKB1WT patients, further confirmed by TCGA data analysis. Conclusions: We validated miR-17 as epigenetic regulator of LKB1 expression in NSCLC tumors. We propose a miR-17 expression score potentially exploitable to discriminate LKB1WT NSCLC patients with impaired LKB1 expression and poor outcome, eligible for energy-stress-based treatments. Citation Format: Cristina Borzi, Monica Ganzinelli, Elisa Caiola, Marika Colombo, Giovanni Centonze, Mattia Boeri, Laura Caleca, Ugo Pastorino, Mirko Marabese, Massimo Milione, Massimo Broggini, Marina C. Garassino, Gabriella Sozzi, Massimo Moro. LKB1 down-modulation by miR-17 biologically and clinically mirrors LKB1-mutated NSCLC [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1539.

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Isaza Gomez, Paula Andrea, et Sandra Juliette Rubio Velasquez. « Review “International Responsibility and Protection of the Environment : In times Of peace, during armed Conflicts and post-conflict Periods” ». Novum Jus 14, n^o 2 (1 juillet 2020) : 333–35. http://dx.doi.org/10.14718/novumjus.2020.14.2.14.

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Book written by Jaime Cubides and Tania Giovanna Vivas-Barrera.Reviewed by: Paula Andrea Isaza Gomez and Sandra Juliette Rubio Velasquez - Students at Universidad Católica de Colombia and editorial assistants at Novum Jus Law Journal.

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Kościukiewicz, Jakub. « Cello in the Baroque, part 2 : Cello literature in the 17th century ». Notes Muzyczny 2, n^o 10 (20 décembre 2018) : 9–23. http://dx.doi.org/10.5604/01.3001.0012.9810.

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The present text is the second instalment of the cycle of articles based on its author’s doctoral dissertation entitled The birth of cello as a solo instrument – instruments, prac-tice, and selected literature examples (Academy of Music in Łódź, 2017). It is an at-tempt to systematise the knowledge about the first cello literature creators and their compositions. The text includes descriptions (characterisations) of the first pieces writ-ten for the cello as early as in the 17th century along with short biographical sketches of their composers. The article characterises the main centres of development of cello mu-sic, such as Bologna and Modena, the places of work of Giovanni Battista Vitali, Do-menico Gabrielli, Petronio Franceschini, Giuseppe Jacchini, Bononcini brothers, Gio-vanni Battista Degli Antoni, Domenico Galii, Giuseppe Colombi, and others. These composers mainly focused around Bologna’s Accademia Filarmonica and Basilica of San Petronio, as well as the court of Francesco II d'Este in Modena. The article also pays attention to the circumstances in which the first attempts to write cello pieces were made. Moreover, it mentions singular historical items of early cello literature written in such centres as Rome, Venice or Naples, where Carlo Fedeli, Giovanni Lorenzo Lulier, Nicola Francesco Haym or other composers worked.

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Fontalvo Herrera, Tomás José, et Gustavo De la Hoz Herrera. « EFICIENCIA DE LOS HOSPITALES DE BOLÍVAR- COLOMBIA POR MEDIO ANÁLISIS ENVOLVENTE DE DATOS // EFFICIENCY OF HOSPITALS BOLIVAR- COLOMBIA THROUGH DATA ENVELOPMENT ANALYSIS // EFICIÊNCIA DOS HOSPITAIS BOLÍVAR-COLOMBIA ANÁLISE POR MORADIA DE DADOS ». Dimensión Empresarial 14, n^o 1 (30 janvier 2015) : 95–108. http://dx.doi.org/10.15665/rde.v14i1.469.

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Esta investigación estudió la eficiencia de 44 Hospitales de Bolívar en el año 2010. Lo anterior por medio de la aplicación de Análisis Envolvente de Datos DEA. Se calcularon las eficiencias técnicas de los Hospitales utilizando el modelo DEA enfocado en salidas CCR-O, lo anterior por medio del estudio de los estados financieros de estos Hospitales. De los 44 Hospitales estudiados, 35 presentaron eficiencia baja, uno presentó una eficiencia media, dos presentaron una eficiencia alta y seis Hospitales mostraron ser eficientes, estos fueron: ESE Hospital local Santa María, ESE Hospital local San José de Achi, seguido por el ESE Centro de salud con camas Cantagallo, ESE Hospital San Antonio de Padua, ESE centro de salud Giovani Cristini, y por último el ESE Hospital local San Fernando. Con esta investigación se pudo concluir que el 13,64% del total de los Hospitales evaluados presentaron una eficiencia óptima. El promedio de la eficiencia de los Hospitales objeto de esta investigación fue de 47,61%.

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Autores, Varios. « Reseña de Libros y Revistas ». Revista Historia de la Educación Latinoamericana 16, n^o 22 (14 janvier 2014) : 339–56. http://dx.doi.org/10.19053/01227238.2723.

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Vera de Flachs, María Cristina (coord.). Historia de las universidades latinoamericanas: tradición y modernidad / 1a ed. – (Córdoba: Báez Ediciones, 2013). 536. Tomo IV Colección Historia y Prospectiva de la Universidad LatinoamericanaFredy Giovany SuárezDiego Eduardo NaranjoUniversidad Pedagógica y Tecnológica de Colombia Jóvenes Investigadores Ilustración en América Colonial - ILAC-

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Rivas Romero, Israel. « Textos artísticos en tiempos de COVID-19. Dos casos en México y Colombia ». Revista EDUCA UMCH, n^o 19 (12 juin 2022) : 138–52. http://dx.doi.org/10.35756/educaumch.202219.215.

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En el presente artículo se analizan las novedades de las expresiones artísticas contemporáneas en torno a la pandemia por el Covid-19. La metodología empleada para tal fin es la de investigación documental. Asimismo, se asumen algunas consideraciones teóricas de la semiótica y la hermenéutica para caracterizar a las expresiones artísticas como textos artísticos. En la primera parte del artículo se recuperan dos antecedentes de textos artísticos en torno a las pandemias en el mundo: el Decamerón de Giovanni Boccaccio y el mural de Keith Haring que lleva por nombre Todos juntos podemos parar el sida. En la segunda parte se realiza una aproximación a las novedades de los textos artísticos elaborados en el marco de la pandemia por el covid-19 a partir de dos ejemplos: el concurso “Miradas artísticas sobre la pandemia. Abrazando la vida” (México) y el libro colectivo “Narrando desde y con el virus” (Colombia). El artículo concluye con el señalamiento de algunos retos de investigación en torno a estos textos artísticos y sus posibles vías de lectura académica.

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du Bois, F. « Gert Bruggemeier, Aurelia Colombi Ciacchi and Giovanni Comande (eds), Fundamental Rights and Private Law in the European Union ». Human Rights Law Review 12, n^o 3 (1 septembre 2012) : 617–24. http://dx.doi.org/10.1093/hrlr/ngs019.

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Martz, John D. « Party Elites and Leadership in Colombia and Venezuela ». Journal of Latin American Studies 24, n^o 1 (février 1992) : 87–121. http://dx.doi.org/10.1017/s0022216x00022963.

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‘By studying political parties we imply that the party is a meaningful unit of analysis. Yet we go above the party as a unit, for we also study the party system. By the same token we can go below the party as a unit and study, thereby, the party subunits.’1 This statement by Giovanni Sartori, while published in 1976, might well have been a beacon for budding stasiologists of the early 1960s — certainly for those with a particular interest in Latin America. Following upon such Western European—orientated classics as the works of Maurice Duverger, Sigmund Neumann and Alfred Diamant,2 there seemed genuine intellectual impetus to produce significant scholarship on the parties of what were then customarily termed either the developing or the ‘non—western’ polities. For Latin America, the time appeared ripe for conceptual progress. To be sure, there was justification in remarking that the study of parties in the region was relatively new, while ‘methodo—logical accomplishments have been primitive’.3 Yet this condition was presumably transitory.In the years to follow there were more serious exploratory efforts, and in time a modest number of case—studies began appearing.4 When the cyclical alternation of democratic and dictatorial regimes began to swing toward the latter by the early 1970s, however, scholarly interest dropped off. More generally, stasiological research went into decline.5 For students of Latin America, only the recent trend toward democratisation has stimulated a revival of interest in parties, campaigns and elections.6 Thus Lorenzo Meyer, for instance, described parties as institutions necessary ‘to channel the energies of social movements, labour unions, and other antiauthoritarian forces present at the beginning of the re—emergence of civil society’.7

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Gutiérrez Hidalgo, Fernando. « Presentación nº 28 Junio 2018 ». De Computis - Revista Española de Historia de la Contabilidad 15, n^o 1 (29 juin 2018) : 1. http://dx.doi.org/10.26784/issn.1886-1881.v15i1.323.

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De Computis presenta su Volumen 15, Número 1 (junio, 2018) incluyendo cuatro trabajos doctrinales realizados por autores de España, Italia y Colombia; y escritos en español e inglés. En el Número también se has publicado dos comentarios bibliográficos. Uno realizado por Pierre Jinghong Liang (Carnegie Mellon University) del libro de Nohora García (Universidad Nacional de Colombia) titulado: “Understanding Mattessich and Ijiri: A Study of Accounting Thought”. El otro realizado por Begoña Prieto (Universidad de Burgos) del libro de Inmaculada Llibrer Escrig y titulado: “Comentario Sobre el libro de Inmaculada Llibrer Escrig (Universidad Católica de Valencia) “Contabilidad y Organización de la Catedral de Valencia en el Siglo XVI”Los autores de este número han sido Mercedes Calvo Cruz (Universidad de las Palmas de Gran Canaria); Carlos Orlando Rico-Bonilla (Universidad Santo Tomás, Colombia); Roberto Rossi (Università degli Studi di Salerno); y Giovanna Centorrino (Università di Messina). Agradecemos a los autores el haber confiado en De Computis para la difusión de sus trabajos.También agradecemos a los revisores su trabajo desinteresado y contribución a los trabajos publicados. Los revisores de los artículos publicados en este número han sido (por el orden alfabético de sus apellidos) Filomena Antunes Brás (Universidade do Minho, Potugal); Michele Bigoni (Universty of Kent, UK); Manoli Dominguez-Orta (Universidad Pablo de Olavide de Sevilla); Alberto Donoso (Universidad de Sevilla); Delfina Gomez (Universidade do Minho, Potugal); Jesús López-Manjón (Universidad Pablo de Olavide de Sevilla); Jorge Tua-Pereda (Universidad Autónoma de Madrid); y Susana Villaluenga (Universidad de Castilla la Mancha).Como podrán ver en este número se han introducido algunos cambios de estilo y de presentación de los artículos (ver por ejemplo la primera página de cada artículo). Con este cambio pretendemos adaptarnos a los modelos de las bases de datos e índices bibliográficos de las revistas científicas.

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Pree, Helmuth. « Colombo, Giovanna Maria, Sapiens aequitas. L'equità nella riflessione canonistica tra i due codici, Roma : Editrice Pontificia Università Gregoriana 2003 (Tesi Gregoriana, Serie Diritto Canonico, 62), 446 S. » Archiv für katholisches Kirchenrecht 172, n^o 1 (24 juin 2003) : 266–69. http://dx.doi.org/10.30965/2589045x-17201031.

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Bez, Maria Rosangela, Fagno da Silva Soares, Néstor Darío Duque Méndez, Valentina Tabares Morales, Thaísa Bueno, Giovana Mesquita, Nelson Russo de Moraes et Francisco Gilson Rebouças Porto Junior. « TECNOLOGIAS DIGITAIS DE INFORMAÇÃO E COMUNICAÇÃO E JORNALISMO EM PAUTA ». Revista Observatório 4, n^o 3 (29 avril 2018) : 28–53. http://dx.doi.org/10.20873/uft.2447-4266.2018v4n3p28.

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A Revista Observatório chega com esperada veemência ao seu quarto ano, com capa produzida pela colega, professora e artista Amanda Leite, trazendo com tenacidade mais dois dossiês especiais! O primeiro, intitulado TECNOLOGIAS DIGITAIS DE INFORMAÇÃO E COMUNICAÇÃO APLICADAS A EDUCAÇÃO, foi organizado pelos colegas Maria Rosangela Bez, da Universidade Feevale – Programa de Pós-Graduação em Diversidade Cultural e Inclusão Social e Colaboradora do Mestrado Profissional em Letras (Brasil), Fagno da Silva Soares, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão (IFMA), Núcleo de Estudos em História Oral (NEHO/USP) e líder do CLIO & MNEMÓSINE - Centro de Estudos e Pesquisas em História Oral e Memória (IFMA) (Brasil), Néstor Darío Duque Méndez, Universidad Nacional de Colombia. Sede Manizales. Grupo de Investigación en Ambientes Inteligentes Adaptativos (GAIA) (Colômbia) e Valentina Tabares Morales, Universidad Nacional de Colombia - Sede Manizales, Departamento de Informática y Computación, Grupo de Ambientes Inteligentes Adaptativos (GAIA) (Colômbia). O segundo, intitulado JORNALISMO EM PAUTA: PERMANÊNCIAS E IMPERMANÊNCIAS, foi organizado pelas colegas Thaísa Bueno do grupo de pesquisa em Comunicação e Cibercultura (Gciber), da Universidade Federal do Maranhão e Giovana Mesquita do Grupo de Pesquisa Dinâmicas do Jornalismo e Grupo Jornalismo e Contemporaneidade, ambos na Universidade Federal de Pernambuco (UFPE).

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Selucká, Markéta. « Book Review : Fundamental Rights and Private Law in the European Union, edited by Gert Brüggemeier, Aurelia Colombi Ciacchi and Giovanni Comandé. (2 Volume Set. Cambridge : Cambridge Un ». Common Market Law Review 49, Issue 3 (1 juin 2012) : 1263–64. http://dx.doi.org/10.54648/cola2012062.

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Residente, Residente. « Neurología ». Acta Médica Colombiana 43, n^o 2S (24 juin 2019) : 220–31. http://dx.doi.org/10.36104/amc.2018.1404.

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NR-1 SINDROME DE WALLENBERG EN EL CONTEXTO DE UNA EMERGENCIA HIPERTENSIVA (COGOLLO MARYSABEL, USTA EDUARDO) NR-2 ESCLEROSIS MÚLTIPLE EN UNA PACIENTE CON SECUELAS DE POLIOMIELITIS (COGOLLO MARYSABEL, USTA EDUARDO, BORRÉ DIANA) NR- 3 SÍNDROME DE VASOCONSTRICCIÓN CEREBRAL REVERSIBLE SECUNDARIO A PARAGANGLIOMA CAROTÍDEO METANEFRINA POSITIVO (ARENAS MAYRA, RICAURTE ANDRÉS, OCAMPO MARIA ISABEL, BARACALDO IVÁN, CORAL JULIANA, JUAN ANDRÉS MEJÍA) NR-4 SÍNDROME DE CALL-FLEMING Y HEMORRAGIA SUBARACNOIDEA ASOCIADO A INHIBIDOR DE AROMATASA: CLAVES EN SU ABORDAJE DIAGNÓSTICO Y TERAPÉUTICO (CORAL JULIANA, MCCORMICK SILVIA, RICAURTE ANDRÉS, BARRACALDO IVÁN, JIMÉNEZ CAMILO, MEJÍA JUAN) NR-5 PARÁMETROS DE RESPIRACIÓN MITOCONDRIAL ESTÁN RELACIONADOS CON LA SEVERIDAD DE SÍNTOMAS COGNITIVOS EN PACIENTES CON ENFERMEDAD DE PARKINSON (PAYÁN-GÓMEZ CÉSAR, MOLANO NICOLÁS, MILANESE CHIARA, MASTROBERARDINO PIER GIORGIO) NR-6 ANGEÍTIS PRIMARIA DEL SISTEMA NERVIOSO CENTRAL EN MUJER CON DEMENCIA RAPIDAMENTE PROGRESIVA: UN REPORTE DE CASO (RIVERA NEIBY, PRIETO JAVIER, BERNAL ADRIANA, MÉNDEZ JUAN, LEGRO GIOVANNI) NR-7 VASCULITIS DE SISTEMA NERVIOSO CENTRAL EN UNA INSTITUCIÓN DE COLOMBIA DURANTE LOS AÑOS 2014 2018 (PÉREZ MARÍA ALEJANDRA, ZULUAGA JUAN DAVID, ROA LUIS FERNANDO) NR-8 ENCEFALITIS AUTOINMUNE POR ANTICUERPOS CONTRA EL RECEPTOR DE NMDA (GRANELA KATYA, BUZÓN EVERT, CHÁVEZ SAMUEL, BROCHADO LEONARDO) NR-9 POLINEUROPATÍA COMO PRESENTACIÓN DE AMILOIDOSIS ASOCIADA A VASCULITIS NECTROTIZANTE (CABRA ANDREA, PRIETO JAVIER, CUERVO MAURICIO) NR-10 DIPLEJIA FACIAL, VARIANTE ATÍPICA DEL SÍNDROME DE GUILLAIN BARRE (CÁRDENAS JOSÉ M., QUINTERO DIANA C.*, LÓPEZ JUANITA, JARAMILLO WILLIAM, HERNÁNDEZ LINA, KLINGER HELEN, OSORIO JUAN M) NR-11 SINDROME ENCEFALOPATIA POSTERIOR REVERSIBLE (PRES): DIAGNOSTICO DIFERENCIAL DE CONVULSIONES EN LUPUS ERITEMATOSO SISTEMICO (FUENTES CARLOS, ESPINOSA DAVID, MORA JAVIER, CUERVO JESSICA, OVIEDO PABLO, PRIETO JAVIER) NR-12 COMPLICACIONES NEUROLOGICAS DEL ALCOHOLISMO (AGUDELO ESTEBAN, ALTMAN DAVID, ÁLVAREZ SEBASTIÁN, ÁNGEL JUAN, ÁNGEL PAOLA, RIOS CESAR AUGUSTO*, BALCAZAR CARLOS MARIO, CARDENAS JOSE MAURICIO)

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Huang, Zhaoliang, Xinghua Pang, Tingting Zhong, Chunshan Jin, Na Chen, Xinrong He, Dennis Xia et al. « 750 AK119, a CD73 targeting antibody with dual mechanism of action ». Journal for ImmunoTherapy of Cancer 9, Suppl 2 (novembre 2021) : A783—A784. http://dx.doi.org/10.1136/jitc-2021-sitc2021.750.

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BackgroundAK119 is an Fc-engineered humanized IgG1 monoclonal antibody targeting human CD73. CD73-extracellular adenosine pathway regulates conversion of pro-inflammatory and immuno-stimulatory extracellular adenosine ATP into immunosuppressive adenosine. CD73 expresses on cancer cells, endothelial cells, fibroblasts, lymphocytes and myeloid cells. CD73 upregulated can be a result of tissue hypoxia,1 epithelial-to-mesenchymal transition,2 inflammation3 and/or cytotoxic stress.4 Also, increasing immune response may lead to faster viral clearance, shorter recovery time, less complications, longer immunity and protection from re-infection. Inhibiting CD73 was reported to evoke B cells activation and shows anti-fibrotic effects. The ability of enhancing immune response provides a potential opportunity to treat COVID-19. Thus, we investigated pharmacological activity of AK119 as an agent treating cancers, COVID-19 and fibrosis.MethodsAK119 inhibition of CD73 enzymatic activity was tested in human PBMCs based assay. The ability of AK119 to enhance B cells immune response was detected by cell-based assay. PBMCs were incubated overnight with APCP (inhibitor of CD73 enzyme acitvity) or AK119, CPI006 or MEDI9447. Flow cytometry analysis was performed with gating on B cells (CD19+CD3-) and MFI and positive percent were reported for antibody staining of CD69 or CD83, as well as HLA-DR and IgM. Enhancement of anti-SARS-CoV-2 antibody production was studied using human CD73 transgenic mouse immunized with SARS-CoV-2 spike protein. The in-vivo activity of AK119 was further studied in bleomycin-induced pulmonary fibrosis model in human CD73 transgenic mouse.ResultsAK119 shows a more potent antigen binding (figure 1) and completely CD73 enzyme inhibition activity (figure 2). AK119 promotes B cell proliferation, and upregulating CD69, CD83, HLA-DR and IgM that are markers of B cell activation (figure 3). B cell activation induced by AK119 is independent of adenosine. AK119 show significantly higher bioactivity to induce B cells activation in comparison with MEDI9447 or CPI006 (figure 4). In human CD73 transgenic mice, AK119 increased secretion of anti-S protein IgG (figure 5). In pulmonary fibrosis mouse model, number of inflammatory cell in broncholveolr lavage fluid of AK119 was significantly decreased, and decreased HYP representing collagen content in lung tissue homogenate of mice was found in both AK119 50 mg/kg and 10 mg/kg group (figure 6).ConclusionsAK119 selectively binds to and inhibits the ectonucleotidase activity of CD73 thus reducing adenosine accumulation. Results from non-clinical pharmacology studies reveal potent bioactivities as well as favorable safety properties of AK119. AK119 is intended for advanced solid tumors, pulmonary fibrosis and therapy of COVID-19.ReferencesBullen JW, Tchernyshyov I, Holewinski RJ, DeVine L, Wu F, Venkatraman V, Kass DL, Cole RN, Van Eyk J, Semenza GL, Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1. Sci Signal 2016;9(430):ra56.Lupia M, Angiolini F, Bertalot G, Freddi S, Sachsenmeier KF, Chisci E, Kutryb-Zajac B, Confalonieri S, Smolenski RT, Giovannoni R, Colombo N, Bianchi F, Cavallaro U. CD73 regulates stemness and epithelial-Mesenchymal transition in ovarian cancer-initiating cells, Stem Cell Rep 2018;10(4):1412–1425.Reinhardt J, Landsberg J, Schmid-Burgk JL, Ramis BB, Bald T, Glodde N, Lopez-Ramos D, Young A, Ngiow SF, Nettersheim D, Schorle H, Quast T, Kolanus W, Schadendorf D, Long GV, Madore J, Scolyer RA, Ribas A, Smyth MJ, Tumeh PC, Tuting T, Holzel M. MAPK signaling and inflammation link melanoma phenotype switching to induction of CD73 during immunotherapy. Cancer Res 2017;77(17):4697–4709.Samanta D, Park Y, Ni X, Li H, Zahnow CA, Gabrielson E, Pan F, Semenza GL. Chemotherapy induces enrichment of CD47(+)/CD73(+)/ PDL1(+) immune evasive triple-negative breast cancer cells, Proc Natl Acad Sci USA. 2018;115(6):E1239–E1248.Abstract 750 Figure 1Binding activity of AK119 to human PBMCs. Binding Curve of AK119 to CD73 expressed on (A) CD8+ T cells and (B) CD19+ B cells in human PBMCsAbstract 750 Figure 2Inhibition activity of CD73 on human PBMCs. AK119 Inhibits Enzymatic Activity of CD73 Expressed on human PBMCsAbstract 750 Figure 3Effect of upregulating B cell markers by AK119. AK119 Upregulates (A) CD69, (B) CD83, (C) HLA-DR and (D) IgM Expression on B cellsAbstract 750 Figure 4Stimulation of B cell Proliferation by AK119Abstract 750 Figure 5Therapeutic activity in the COVID-19 mouse model. Serum Concentration of S protein-specific IgG in Mouse Model of COVID-19Abstract 750 Figure 6Therapeutic activity in the asthma mouse model. (A) AK119 relieves the increased airway resistance and restore the lung function. (B) Reduction of the inflammatory cells in BALF by AK119

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Arteaga Montes, Giovanny Paolo. « Carlos Camacho Arango. El conflicto de Leticia (1932-1933) y los ejércitos de Perú y Colombia (Bogotá : Universidad Externado de Colombia – Colección Centro de Estudios en Historia (CEHIS), 2016). » Historia y Espacio 13, n^o 49 (13 novembre 2017). http://dx.doi.org/10.25100/hye.v13i49.5855.

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Reseña Carlos Camacho Arango. El conflicto de Leticia (1932-1933) y los ejércitos de Perú y Colombia (Bogotá: Universidad Externado de Colombia – Colección Centro de Estudios en Historia (CEHIS), 2016). Por: Giovanny Paolo Arteaga Montes

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Hough, Phillip. « Global Commodity Chains and the Spatial-Temporal Dimensions of Labor Control : Lessons from Colombias Coffee and Banana Industries ». Journal of World-Systems Research, 26 août 2010, 123–61. http://dx.doi.org/10.5195/jwsr.2010.450.

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In this paper, the author seeks to explain the trajectories of local labor regime dynamics in Colombias coffee and banana industries from the post war developmental decades until the present. In order to explain these dynamics, the author first develops a neo-Gramscian ideal-typical schema to highlight the full range of labor regime dynamics emergent in Colombia, including hegemonic, despotic, and crisis regimes. The author then develops a theory of local labor regime types that draws from Giovanni Arrighis work on commodity chains. Finally, using comparative and world-historical methods, the author finds that the shifting trajectories of labor regimes in Colombia are affected by the nodal location of these regimes within their respective commodity chains.

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« An Integrated Framework for Genetic Improvement and Artificial Breeding of Beef Cattle : a Case Study in Livestock Industry of Colombia ». International Journal of Advanced Trends in Computer Science and Engineering 8, n^o 1 (15 février 2019) : 62–70. http://dx.doi.org/10.30534/ijatcse/2019/11812019.

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Graziadei, Michele. « Fundamental Rights and Private Law in the European Union : Volume I : A Comparative Overview ; Volume II : Analyses of Selected Case Patterns, edited by Gert Brüggemeier, Aurelia Colombi Ciacchi, Giovanni Commandé, Cambridge University Press, Cambridge, 2010, i–808 ; i–456. » European Review of Contract Law 7, n^o 4 (janvier 2011). http://dx.doi.org/10.1515/ercl.2011.573.

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Articles de revues sur le sujet « Giovanni Colombo »

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