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Littérature scientifique sur le sujet « Germline gene editing »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 25 juillet 2025

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Articles de revues sur le sujet "Germline gene editing"

Cwik, Bryan. "Intergenerational monitoring in clinical trials of germline gene editing." Journal of Medical Ethics 46, no. 3 (2019): 183–87. http://dx.doi.org/10.1136/medethics-2019-105620.

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Design of clinical trials for germline gene editing stretches current accepted standards for human subjects research. Among the challenges involved is a set of issues concerning intergenerational monitoring—long-term follow-up study of subjects and their descendants. Because changes made at the germline would be heritable, germline gene editing could have adverse effects on individuals’ health that can be passed on to future generations. Determining whether germline gene editing is safe and effective for clinical use thus may require intergenerational monitoring. The aim of this paper is to id

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Sugarman, Jeremy. "Ethics and germline gene editing." EMBO reports 16, no. 8 (2015): 879–80. http://dx.doi.org/10.15252/embr.201540879.

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Mason, Veronica R. J. M. "Hurtling toward Germline Gene Editing." Ethics & Medics 44, no. 8 (2019): 1–4. http://dx.doi.org/10.5840/em201944811.

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Genetic enhancement runs up against several moral issues, perhaps the chief of which is the inevitable eugenic attitude it would foster and the associated inequality it would create between those who have the “proper” enhancements and those who do not. For simplicity’s sake, this analysis leaves aside questions related to genetic enhancement and considers only changes made for therapeutic purposes. Regardless, most of the censure of He Jiankui focuses on the results of human modification and often overlooks the prior question of how gene editing research itself conducted. Germline gene editing

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Cartier-Lacave, Nathalie, Robin Ali, Seppo Ylä-Herttuala, et al. "Debate on Germline Gene Editing." Human Gene Therapy Methods 27, no. 4 (2016): 135–42. http://dx.doi.org/10.1089/hgtb.2016.28999.deb.

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Nalley, Catlin. "Germline Gene Editing for Deafness." Hearing Journal 73, no. 2 (2020): 28. http://dx.doi.org/10.1097/01.hj.0000654908.10936.e1.

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Ewuoso, Cornelius. "Germline Gene Editing Applications and the Afro-communitarian Ubuntu Philosophy." Filosofia Theoretica: Journal of African Philosophy, Culture and Religions 12, no. 1 (2023): 1–12. http://dx.doi.org/10.4314/ft.v12i1.1.

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Germline gene editing has many applications or uses. This article focuses on specific applications. Specifically, the article draws on a moral norm arising from the thinking about the value of communal relationships in the Afro-communitarian ubuntu philosophy to interrogate key issues that specific applications of germline gene editing – for xeno-transplantation, agriculture and wildlife – raise. The article contends that the application of germline gene editing in these areas is justified to the extent that they foster the capacity to relate with others and to be communed with by others. The

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Gyngell, Christopher, Thomas Douglas, and Julian Savulescu. "The Ethics of Germline Gene Editing." Journal of Applied Philosophy 34, no. 4 (2016): 498–513. http://dx.doi.org/10.1111/japp.12249.

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Ranisch, Robert, Tina Rudolph, Hans-Joachim Cremer, and Nikolaus Knoepffler. "Ordo-Responsibility for Germline Gene Editing." CRISPR Journal 3, no. 1 (2020): 37–43. http://dx.doi.org/10.1089/crispr.2019.0040.

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Savvina, Olga V. "Genetic Modification of Human Embryos: Limits." Ethical Thought 22, no. 1 (2022): 124–34. http://dx.doi.org/10.21146/2074-4870-2022-22-1-124-134.

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The article analyses the moral justification of human germline editing and the tendency to its legalization. The study is based on documents of international organizations, such as the World Health Organization (WHO), national bioethics committees and others that regulate the usage of technologies for human germline editing or issue related recommendations. The paper analyzes the impact of the introduction of new technologies on human germline editing recommendations. It is concluded that that the development of biotechnologies contributes to liberal attitude towards human germline editing,

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Ryu, Junghyun, Eli Y. Adashi, and Jon D. Hennebold. "The History, Use, and Challenges of Therapeutic Somatic Cell and Germline Gene Editing." Obstetrical & Gynecological Survey 79, no. 3 (2024): 143–45. http://dx.doi.org/10.1097/01.ogx.0001010424.79207.9c.

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ABSTRACT Gene editing is a technology that has been rapidly developing and that has many applications as well as ethical and practical implications. This article is a review that outlines the history of current technology, as well as the advantages and challenges in use for somatic cell and germline gene editing. Clustered regularly interspaced short palindromic repeat (CRISPR) was first introduced in 2002 and initially saw limited use among researchers. However, in 2012, it was discovered that a nuclease associated with CRISPR (Cas9) could be used with guide RNA to cleave double-stranded DNA

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Thèses sur le sujet "Germline gene editing"

Svensson, Ellen. "CRISPR AND THETREATMENT/EN DISTINCTION : On Vagueness, Borderline Cases and Germline Genome Editing." Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184615.

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In this thesis, I argue that the treatment/enhancement distinction that is central to the ethical debate concerning germline genome editing and CRISPR is too vague to be ethically and normatively guiding. The problem of vagueness is twofold, being both a semantic and epistemic issue. This vagueness creates borderline cases, cases that cannot be properly defined as either treatment or enhancement, I call this The Borderline Cases Argument. These borderline cases enable a slippery slope towards eugenic practices, radical enhancement and dangerous applications of CRISPR. The distinction therefore

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BONOMELLI, SARA. "L'EDITING GENETICO GERMINALE UMANO, TRA PROBLEMI ETICI E QUESTIONI DI GOVERNANCE." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/922688.

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The dissertation aims at identifying and analyzing the scientific, legal, and ethical issues raised by the perspective of intentional modification of human germline by the potential future use of gene editing techniques in the context of human reproduction. Such a study makes it possible to formulate some critical considerations about human germline gene editing governance. The dissertation claims that the best option to regulate the use of this biotechnological innovation for reproductive purposes consists of a regulation on a state-by-state-basis, which should however be developed within a

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Hedberg, Rickard. "Preimplantation genetic diagnosis and therapy in humans- Opportunities and risks." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81532.

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IntroductionPreimplantation Genetic Diagnosis (PGD) was developed in the 1990s and has been used since to diagnose and discard embryos with genetic conditions or chromosomal abnormalities. CRISPR-Cas9 was discovered in 2012 and has been used in research, but has not become clinical practice on humans yet. CRISPR-Cas9 could potentially be applied to treat and prevent genetic disorders.AimThe aim was to investigate the ethical dilemmas of each method through a set of research questions. The ethics of applying PGD according to Swedish guidelines and applying CRISPR-Cas9 on humans was investigated

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Botas, Bruna Patrícia Marques. "Edição Genética em Embriões Humanos - A Responsabilidade Civil Médica No Contexto da Terapia Génica Germinal." Master's thesis, 2021. http://hdl.handle.net/10316/97516.

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Dissertação de Mestrado em Direito apresentada à Faculdade de Direito<br>O mundo tem vindo a assistir grandes desenvolvimentos no domínio da genética e medicina reprodutiva, passando-se a falar da “Revolução GNR (Genética, Nanotecnologia e Robótica)”, capaz de promover a saúde e qualidade de vida humana, como nunca antes. O avanço que maior destaque tem tido na comunidade científica e que será aqui objeto de estudo, insere-se no contexto da Engenharia genética, com o surgimento da tecnologia CRISPR/Cas com potencialidade de corrigir, substituir e modificar o genoma humano, de forma rápida e pr

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Livres sur le sujet "Germline gene editing"

de Melo-Martín, Inmaculada. Reprogenetic Technologies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190460204.003.0002.

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This chapter offers a brief description of the main reprogenetic technologies in use today as well as some of the most significant ones being developed. Because of their relevance in the field, particular attention is given to in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD). The chapter discusses the differences between somatic and germline modifications, the most common uses of reprogenetic technologies today, and some possible and likely future uses. It also includes a description of recent technological advances such as mitochondrial transfer and gene editing techni

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van Beers, Britta. Imagining Future People in Biomedical Law. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780198795896.003.0007.

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Human genetic engineering and other human enhancement technologies bring about uncertainties and risks on both the physical and the conceptual and intangible levels. Much of the controversy surrounding these emerging technologies is due to the fact that categorical distinctions, such as between person and thing, and chance and choice, are blurred in radical ways. As a consequence, the emergence of biomedical technologies also entails, what could be called, metaphysical risks and symbolic uncertainties. This chapter explores the ways in which imaginings of the future of mankind and mankind itse

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Joyner, Alexandra, ed. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.

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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first

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Chapitres de livres sur le sujet "Germline gene editing"

Hayenhjelm, Madeleine, and Christer Nordlund. "Consequence Arguments for and Against Germline Editing." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_7.

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Abstract This chapter explores various consequence-based arguments on the ethics of germline gene editing. First, the chapter distinguishes between descriptive and normative consequence arguments. Second, it takes a deep dive into arguments related to risks and safety, on the one hand, and into arguments related to prospective benefits, on the other. Both arguments for and against germline gene editing appeal to different kinds of consequence-arguments. The chapter highlight various questions raised by a focus on the potential consequences. This includes the question of who the beneficiary of

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Hayenhjelm, Madeleine, and Christer Nordlund. "Introduction." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_1.

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Abstract Is there a moral line to be drawn at the human germline? For a long time, the dominant view on gene technology was that there is a moral line drawn at the human germline such that somatic gene editing as part of therapy is morally permissible, but heritable gene editing of early embryos or germline cells is not. The germline has been interchangeably referred to as a “boundary,” a “barrier,” and a “red line.” This previously dominant position has slowly weakened over the past decade. Has the germline as a moral boundary lost its relevance? The aim of the book The Risks and Ethics of Hu

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Hayenhjelm, Madeleine, and Christer Nordlund. "Categorical Objections to Germline Editing." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_6.

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Abstract This chapter takes a closer look at so-called categorical objections to human germline gene editing. Categorical objections played an important part in some of the earlier debate and has informed some of the legal and regulatory frameworks on germline gene editing. The chapter explores different categorical objections as well as various objections to these. Are there convincing reasons to presume that germline gene editing interventions violates fundamental moral norms? The chapter explores different versions of such arguments based on deontological concepts such as human dignity, ind

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Chiong, Siddharta B., and Nicanor Austriaco. "Germline gene editing with CRISPR." In The Routledge Handbook of the Ethics of Human Enhancement. Routledge, 2023. http://dx.doi.org/10.4324/9781003105596-15.

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Zaretsky, Adam. "Human germline gene editing is bioart." In Routledge Handbook of Art, Science, and Technology Studies. Routledge, 2021. http://dx.doi.org/10.4324/9780429437069-34.

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Hayenhjelm, Madeleine, and Christer Nordlund. "A New Pair of Scissors and Moral Alarm Bells." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_2.

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Abstract The chapter gives a short background to the ethical debates surrounding the gene editing tool CRISPR. It discusses the early worries and alarm bells when the first studies came out that demonstrated that heritable germline editing on humans was realistically possible as well as the subsequent calls for ethics. Three key distinctions that has done a lot of moral boundary work in this debate are presented: between somatic and germline interventions; between research and clinical application; and between therapy and enhancement.

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Hayenhjelm, Madeleine, and Christer Nordlund. "Lingering Concerns." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_9.

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Abstract Is there something particularly morally problematic about human germline gene editing, to the extent that it would warrant another moral approach than weighing the pros against the cons, or asking whether it violates any moral principles or norms? In this chapter the ethical arguments discussed in the previous chapters is revisited via the perspective of risk. The relevant risks are divided into three different kinds—technical, social, and moral and metaphysical risks—and it is also discussed what the “most severe kind of risks” would be. Are there things that we could not live with h

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Hayenhjelm, Madeleine, and Christer Nordlund. "Three Moral Perspectives on the Permissibility of Germline Editing." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_4.

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Abstract The chapter identifies and explores three distinct moral outlooks found in the gene editing debate with different implications on what the relevant moral questions and answers are with regard to germline gene editing. The Technical View equates ethical questions with questions about the direct risks of the intervention itself, that is if it is sufficiently safe and precise. The Democratic View stress that ethical questions are not only technical questions, but also pertain to values and must find solutions that all affected parties can agree upon. Finally, the Moral View treats the et

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Hayenhjelm, Madeleine, and Christer Nordlund. "Enhancement Arguments." In Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer Fachmedien Wiesbaden, 2025. https://doi.org/10.1007/978-3-658-46979-5_8.

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Abstract The chapter takes a closer look at arguments for and against germline gene editing for human enhancement, including radical human enhancement. On the one hand, there are hopes of taking control of evolution, dreams of perfecting humankind and reaching a posthuman Utopia, and visions of saving humanity from natural disasters, while on the other hand, there are fears about jeopardizing the existence of humanity itself. Even though these arguments are indeed speculative, it is stressed in the chapter that they raise some difficult questions about the kind of future we value, who we might

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Obermeier, Mariella, Vera Rogiers, Tamara Vanhaecke, and Yoni Baert. "Lipofection-Based Delivery of CRISPR/Cas9 Ribonucleoprotein for Gene Editing in Male Germline Stem Cells." In Methods in Molecular Biology. Springer US, 2024. http://dx.doi.org/10.1007/978-1-0716-3698-5_10.

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Rapports d'organisations sur le sujet "Germline gene editing"

Morin, S., L. L. Walling, Peter W. Atkinson, J. Li, and B. E. Tabashnik. ets for CRISPR/Cas9-mediated gene drive in Bemisia tabaci. United States-Israel Binational Agricultural Research and Development Fund, 2021. http://dx.doi.org/10.32747/2021.8134170.bard.

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The goal of our BARD proposal was to build both the necessary infrastructure and knowledge for using the CRISPR/Cas9-based gene drive system to control the whitefly Bemisia tabaci. Our research focused on achieving three main goals: (1) establishing a CRISPR/Cas9 gene-editing system for producing genetically-edited B. tabaci; (2) generating and testing CRISPR/Cas9-mediated mutations targeting genes that represent two gene drive strategies: population replacement and population suppression; (3) using computer modeling to optimize strategies for applying CRISPR/Cas9 to control B. tabaci populati

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