Littérature scientifique sur le sujet « Germline gene editing »
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Articles de revues sur le sujet "Germline gene editing"
Sugarman, Jeremy. « Ethics and germline gene editing ». EMBO reports 16, no 8 (2 juillet 2015) : 879–80. http://dx.doi.org/10.15252/embr.201540879.
Texte intégralMason, Veronica R. J. M. « Hurtling toward Germline Gene Editing ». Ethics & ; Medics 44, no 8 (2019) : 1–4. http://dx.doi.org/10.5840/em201944811.
Texte intégralCartier-Lacave, Nathalie, Robin Ali, Seppo Ylä-Herttuala, Kazuto Kato, Bernard Baetschi, Robin Lovell-Badge, Luigi Naldini et Adrian Thrasher. « Debate on Germline Gene Editing ». Human Gene Therapy Methods 27, no 4 (août 2016) : 135–42. http://dx.doi.org/10.1089/hgtb.2016.28999.deb.
Texte intégralNalley, Catlin. « Germline Gene Editing for Deafness ». Hearing Journal 73, no 2 (février 2020) : 28. http://dx.doi.org/10.1097/01.hj.0000654908.10936.e1.
Texte intégralCwik, Bryan. « Intergenerational monitoring in clinical trials of germline gene editing ». Journal of Medical Ethics 46, no 3 (31 août 2019) : 183–87. http://dx.doi.org/10.1136/medethics-2019-105620.
Texte intégralGyngell, Christopher, Thomas Douglas et Julian Savulescu. « The Ethics of Germline Gene Editing ». Journal of Applied Philosophy 34, no 4 (9 novembre 2016) : 498–513. http://dx.doi.org/10.1111/japp.12249.
Texte intégralRanisch, Robert, Tina Rudolph, Hans-Joachim Cremer et Nikolaus Knoepffler. « Ordo-Responsibility for Germline Gene Editing ». CRISPR Journal 3, no 1 (1 février 2020) : 37–43. http://dx.doi.org/10.1089/crispr.2019.0040.
Texte intégralCwik, Bryan. « Designing Ethical Trials of Germline Gene Editing ». New England Journal of Medicine 377, no 20 (16 novembre 2017) : 1911–13. http://dx.doi.org/10.1056/nejmp1711000.
Texte intégralSharma, Akshay, Nickhill Bhakta et Liza-Marie Johnson. « Germline Gene Editing for Sickle Cell Disease ». American Journal of Bioethics 20, no 8 (2 août 2020) : 46–49. http://dx.doi.org/10.1080/15265161.2020.1781970.
Texte intégralKoplin, Julian J., Christopher Gyngell et Julian Savulescu. « Germline gene editing and the precautionary principle ». Bioethics 34, no 1 (27 juin 2019) : 49–59. http://dx.doi.org/10.1111/bioe.12609.
Texte intégralThèses sur le sujet "Germline gene editing"
Svensson, Ellen. « CRISPR AND THETREATMENT/EN DISTINCTION : On Vagueness, Borderline Cases and Germline Genome Editing ». Thesis, Umeå universitet, Institutionen för idé- och samhällsstudier, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184615.
Texte intégralBONOMELLI, SARA. « L'EDITING GENETICO GERMINALE UMANO, TRA PROBLEMI ETICI E QUESTIONI DI GOVERNANCE ». Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/922688.
Texte intégralHedberg, Rickard. « Preimplantation genetic diagnosis and therapy in humans- Opportunities and risks ». Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81532.
Texte intégralBotas, Bruna Patrícia Marques. « Edição Genética em Embriões Humanos - A Responsabilidade Civil Médica No Contexto da Terapia Génica Germinal ». Master's thesis, 2021. http://hdl.handle.net/10316/97516.
Texte intégralO mundo tem vindo a assistir grandes desenvolvimentos no domínio da genética e medicina reprodutiva, passando-se a falar da “Revolução GNR (Genética, Nanotecnologia e Robótica)”, capaz de promover a saúde e qualidade de vida humana, como nunca antes. O avanço que maior destaque tem tido na comunidade científica e que será aqui objeto de estudo, insere-se no contexto da Engenharia genética, com o surgimento da tecnologia CRISPR/Cas com potencialidade de corrigir, substituir e modificar o genoma humano, de forma rápida e precisa, visando o aprimoramento genético e/ou a prevenção e tratamento de doenças/malformações genéticas. Contudo, com ela surgem também riscos que colocam em dúvida a sua utilização no contexto da prática clínica, reclamando o debate público, a sua regulamentação e o estabelecimento de critérios a serem seguidos caso o seu uso venha a ser admitido. Não obstante, várias são as normas internacionais, supranacionais e nacionais, com princípios norteadores da investigação científica e prática clínica, no contexto da genética e da biomedicina, que iremos evidenciar. Com base nessa análise, passaremos para a consideração dos dilemas ético-jurídicos que surgem à volta da terapia génica germinal e que se prendem com direitos fundamentais do ser humano. E, sendo esta uma realidade cada vez mais próxima, importa a reflexão acerca da responsabilidade civil dos médicos, por danos que possam surgir no âmbito da terapia génica germinal, analisando os seus pressupostos, focando-nos no domínio privado, e na consequente propositura das wrong actions e surgimento das novas ações de wrongful genetic makeup. Neste caminho, refletimos ainda acerca do eventual surgimento de novos direitos e danos daí decorrentes, fazendo, por fim, breve reflexão sobre os prazos de prescrição, tendo em conta a incerteza e tardia manifestação desses danos. Concluímos defendendo a admissibilidade da terapia génica germinal, ainda que após debate público, reflexão sobre a responsabilidade civil dos profissionais de saúde pelas lesões que daí possam surgir, e regulamentação e fixação de critérios que garantam a segurança das técnicas.
The world has been witnessing great developments in the field of genetics and reproductive medicine, arising the “GNR (Genetics, Nanotechnology and Robotics) Revolution”, capable of promoting human health and quality of life like never before. The most prominent advance in the scientific community which will be the object of study here is part of the context of genetic engineering, which is the emergence of the CRISPR/Cas technology with the potential to correct, replace and modify the human genome, in a more precise and faster way, aiming at genetic enhancement and/or the prevention and treatment of genetic diseases/malformations. However, with it arises risks that cast doubt on its use in the context of clinical practice, demanding public debate, its regulation, and the establishment of criteria to be followed if its use is admitted. Nevertheless, there are several international, supranational and national norms, with guiding principles for scientific research and clinical practice, in the context of genetics and biomedicine, which will be highlighted.Based on this analysis, we will move on to the consideration of the ethical-juridical dilemmas that arise around germinal gene therapy and that relate to fundamental human rights. And, as this reality is ever closer, it is important to reflect on the civil liability of physicians, for damages that may arise in the context of germinal gene therapy, analyzing its assumptions, focusing on the private domain, and the consequent proposition of wrong actions and the emergence of new wrongful genetic makeup actions. On this path, we also reflect on the possible emergence of new rights and damages arising from these techniques, finally making a brief reflection on the limitation periods, considering the uncertainty and late manifestation of these damages. We conclude defending the admissibility of germinal gene therapy, only after a public debate, reflection on civil liability of health professionals for the damages that may arise from it, and fixation of criteria that guarantee the safety of the techniques.
Livres sur le sujet "Germline gene editing"
de Melo-Martín, Inmaculada. Reprogenetic Technologies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190460204.003.0002.
Texte intégralvan Beers, Britta. Imagining Future People in Biomedical Law. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780198795896.003.0007.
Texte intégralJoyner, Alexandra, dir. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.
Texte intégralChapitres de livres sur le sujet "Germline gene editing"
Zaretsky, Adam. « Human germline gene editing is bioart ». Dans Routledge Handbook of Art, Science, and Technology Studies, 450–64. London : Routledge, 2021. http://dx.doi.org/10.4324/9780429437069-34.
Texte intégralSýkora, Peter. « Chapter 11 Germline Gene Therapy in the Era of Precise Genome Editing : How Far Should We Go ? » Dans The Ethics of Reproductive Genetics, 157–71. Cham : Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-60684-2_11.
Texte intégralEllison, Evan E., James C. Chamness et Daniel F. Voytas. « Viruses as vectors for the delivery of gene-editing reagents ». Dans Genome editing for precision crop breeding, 97–122. Burleigh Dodds Science Publishing, 2021. http://dx.doi.org/10.19103/as.2020.0082.28.
Texte intégralEvans, John H. « Possible Barriers Further Down the Slope ». Dans The Human Gene Editing Debate, 111–33. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780197519561.003.0004.
Texte intégralEvans, John H. « The First Barriers in the Human Genetic Engineering Debate ». Dans The Human Gene Editing Debate, 25–66. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780197519561.003.0002.
Texte intégralEvans, John H. « The CRISPR Era, the National Academies Report, and the Median Trait Barrier ». Dans The Human Gene Editing Debate, 67–110. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780197519561.003.0003.
Texte intégralHauskeller, Michael. « Editing the Best of All Possible Worlds ». Dans Human Flourishing in an Age of Gene Editing, 61–71. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190940362.003.0005.
Texte intégralHochschild, Jennifer. « Who Should Govern ? » Dans Genomic Politics, 186–219. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197550731.003.0008.
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