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Articles de revues sur le sujet « Gene editing governance »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 31 juillet 2025

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1

C&EN editorial staff. "Gene editing calls for good governance." C&EN Global Enterprise 102, no. 32 (2024): 2. http://dx.doi.org/10.1021/cen-10232-editorial.

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Marchant, Gary E. "Global Governance of Human Genome Editing: What Are the Rules?" Annual Review of Genomics and Human Genetics 22, no. 1 (2021): 385–405. http://dx.doi.org/10.1146/annurev-genom-111320-091930.

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Human gene editing, particularly using the new CRISPR/Cas9 technology, will greatly increase the capability to make precise changes to human genomes. Human gene editing can be broken into four major categories: somatic therapy, heritable gene editing, genetic enhancement, and basic and applied research. Somatic therapy is generally well governed by national regulatory systems, so the need for global governance is less urgent. All nations are in agreement that heritable gene editing should not proceed at this time, but there is likely to be divergence if and when such procedures are shown to be

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Xue, Yang, and Lijun Shang. "Governance of Heritable Human Gene Editing World-Wide and Beyond." International Journal of Environmental Research and Public Health 19, no. 11 (2022): 6739. http://dx.doi.org/10.3390/ijerph19116739.

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To date, the controversy surrounding the unknown risks and consequences of heritable genome editing has grown, with such work raising biosafety and ethical concerns for future generations. However, the current guideline of global governance is limited. In the context of the new framework for the governance of human genome editing developed by the World Health Organization (WHO) committee, this paper presents further analysis by highlighting predicaments of governance on germline engineering that merit the most attention: (1) building a scientific culture informed by a broader set of values and

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Gordon, Doria R., Gregory Jaffe, Michael Doane, Aviva Glaser, Thomas M. Gremillion, and Melissa D. Ho. "Responsible governance of gene editing in agriculture and the environment." Nature Biotechnology 39, no. 9 (2021): 1055–57. http://dx.doi.org/10.1038/s41587-021-01023-1.

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Riggan, Kirsten A., Richard R. Sharp, and Megan Allyse. "Where Will We Draw the Line? Public Opinions of Human Gene Editing." Qualitative Health Research 29, no. 12 (2019): 1823–35. http://dx.doi.org/10.1177/1049732319846867.

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The application of gene editing technologies to prevent or mitigate genetic disease in humans is considered one of its most promising applications. However, as the technology advances, it is imperative to understand the views of the broader public on how it should be used. We conducted focus groups to understand public views on the ethical permissibility and governance of gene editing technologies in humans. A total of 50 urban and semirural residents in the upper Midwest took part in six focus groups. Participants expressed multiple concerns about nonmedical uses of gene editing and its poten

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Fernando, Kalani, Duminda De Silva, and Asanka Ekanayake. "Regulatory Frameworks for Human Gene Editing: A Systematic Literature Review." International Journal of Law and Policy 3, no. 6 (2025): 21–49. https://doi.org/10.59022/ijlp.333.

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Human gene editing technologies, especially CRISPR-Cas9, have advanced rapidly, raising complex regulatory, ethical, and scientific issues. This study reviews 47 peer-reviewed articles published between 2015 and 2025, following PRISMA 2020 guidelines. The analysis reveals major empirical, theoretical, methodological, and practical gaps in governance. It notes a lack of global harmonisation, weak ethical oversight, and inconsistent national policies that obstruct responsible innovation. Developing countries often lack enforceable guidelines, while developed nations use varied regulatory framewo

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Stasi, Alessandro, and Onnida Thongpravati. "Biotechnology Innovation in Do-It-Yourself (DIY) Gene Editing: A Call for a New Regulatory Framework." OBM Genetics 08, no. 02 (2024): 1–11. http://dx.doi.org/10.21926/obm.genet.2402238.

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The expansion of do-it-yourself (DIY) gene editing, facilitated by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology, has catalyzed a significant shift in scientific research and biotechnology innovation. This movement is propelled by a community-driven approach that challenges the traditional confines of scientific exploration, allowing amateur scientists to perform sophisticated biological experiments. While this democratization fosters inclusivity and accelerates innovation, it simultaneously introduces significant biosecurity risks. The possibility of unregulate

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Eichmeier, April A., and Michael A. Xenos. "CRISPR is easy: Exposure to Last Week Tonight enhances knowledge about gene editing." PLOS ONE 19, no. 10 (2024): e0306563. http://dx.doi.org/10.1371/journal.pone.0306563.

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Experts have called for public engagement with the governance of controversial scientific research and discoveries, including CRISPR, the technology that enables gene editing. Though engaging and informing citizens who are not interested in the issue is a challenge, recent studies suggest humor has potential to close interest and knowledge gaps. We tested this potential by exposing individuals (N = 303) to one of three videos (an edited clip from Last Week Tonight, an edited clip from 60 Minutes, or control) that contained broadly overlapping facts about gene editing in an online survey. Resul

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Yüksel, Fatma. "Comprehensive Exploration of CRISPR and Gene Editing Technologies: Applications, Ethical Considerations, and Future Implications in Genetic Research." Next Frontier For Life Sciences and AI 8, no. 1 (2024): 69. http://dx.doi.org/10.62802/3nwhcj06.

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CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and other gene-editing technologies have revolutionized genetic research by enabling precise, targeted modifications of DNA sequences. This paper provides a comprehensive exploration of CRISPR technology, detailing its development, mechanism of action, and versatility in diverse applications. From advancements in medicine, including therapeutic interventions for genetic disorders, to innovations in agriculture aimed at enhancing crop resilience and yield, CRISPR's transformative potential is vast. However, the rapid evolution o

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Saldaña Tejeda, Abril. "Global divisions of health; bioethical principles, practices and regulations on human genome editing and stem cell research in Latin America." Bionatura 4, no. 3 (2019): 895–96. http://dx.doi.org/10.21931/rb/2019.04.03.2.

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Recent genetic technologies have uncovered the urgent need for global governance of health that can guarantee an ethical consensus on human genome editing and stem cell research. Although the majority of gene-transfer trials have been located in the Americas and Europe, the regulation of human somatic cell genome editing is generally limited in Latin America and largely informed by ethical concerns about genetically modified plants and animals, biopiracy, biosecurity, and use of stem cells for clinical care. Few jurisdictions in the region (i.e., Chile, Panama, Ecuador, and Colombia) have expl

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Mainaly, Shiva. "Diversity, Equity, And Inclusion (Dei) Quotient in The Age of Crispr-Cas 9: A Speculative Spectrum of Argumentation." International Journal of Arts, Humanities & Social Science 05, no. 04 (2024): 63–71. http://dx.doi.org/10.56734/ijahss.v5n4a4.

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The advent of CRISPR-Cas9 gene-editing technology has sparked a complex discourse on diversity, equity, and inclusion (DEI). While it could potentially eradicate genetic disorders affecting marginalized groups, concerns arise regarding ethical implications, eugenics, exacerbating biases, and socioeconomic divides. One salient aspect of this discourse pertains to the ethical considerations surrounding using CRISPR-Cas9 for germline editing, which could theoretically eradicate genetic disorders disproportionately affecting specific populations. Proponents argue it could foster inclusivity throug

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Aliyev, Tofiq, and Duyğu Eyvazova. "Genetic Engineering and Its Ethical Implications: A Bioethical Perspective." Luminis Applied Science and Engineering 2, no. 1 (2025): 57–64. https://doi.org/10.69760/lumin.20250001010.

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Genetic engineering has revolutionized the fields of medicine, agriculture, and biotechnology, offering unprecedented control over DNA modification. The development of CRISPR-Cas9 and other gene-editing tools has enabled precise genetic alterations, raising both scientific opportunities and ethical dilemmas. This paper explores the methodologies of germline and somatic gene editing, the applications of gene drives in conservation, and the corporate influence on genetically modified organisms (GMOs). Ethical concerns regarding human genetic modification, ecological risks, and economic inequalit

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Macnaghten, Phil, and Michelle G. J. L. Habets. "Breaking the impasse: Towards a forward‐looking governance framework for gene editing with plants." PLANTS, PEOPLE, PLANET 2, no. 4 (2020): 353–65. http://dx.doi.org/10.1002/ppp3.10107.

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Namusisi H, Nambi. "Synthetic Biology: Creating Custom Organisms for Industry." Research Output Journal of Engineering and Scientific Research 4, no. 2 (2025): 95–100. https://doi.org/10.59298/rojesr/2025/4.2.95100.

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Synthetic biology represents a transformative interdisciplinary field that integrates biology, engineering, and computational science to design and construct new biological entities and systems. This paper examines the scientific foundations and historical emergence of synthetic biology, highlighting its technological advances in gene editing, DNA synthesis, metabolic engineering, and the design of custom organisms. It examines industrial applications across sectors such as pharmaceuticals, agriculture, and biofuels, illustrating how synthetic biology enables the production of tailored organis

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LEONE, Luca. "Gene Editing for the EU Agrifood: Risks and Promises in Science Regulation." European Journal of Risk Regulation 10, no. 4 (2019): 766–80. http://dx.doi.org/10.1017/err.2019.55.

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In today’s innovation-driven agrifood domain, the perspective of using so-called New Breeding Techniques (NBTs) on both non-human animals and plants calls into question the regulatory approach (process/product-based) to be used, while asking for a critical reflection on the potential impact of products on the industrial sector and citizens. A possible reconfiguration of European (EU) discipline will have to grapple with not only agrifood market’s interests and needs, but mostly and primarily with the growing quest for public and participatory discussion on the current dominant vision on life s

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Dr.A.Shaji, George, George A.S.Hovan, Himika Devi Dr.Salam, and Shahul Aakifa. "Your Future Kids Might Be Genetically Engineered: Implications, Possibilities, and Ethical Considerations." Partners Universal Innovative Research Publication (PUIRP) 03, no. 02 (2025): 1–9. https://doi.org/10.5281/zenodo.15249246.

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Recent advances in gene editing and reproductive technologies may enable prospective parents to genetically modify embryos before implantation, raising the possibility of "designer babies." This could eliminate inherited diseases, select traits like intelligence and athleticism, and enable same-sex couples to biologically conceive. However, it also poses ethical issues around inequality, regulation, safety concerns from manipulating the human genome, and the overall societal impacts of steering human evolution. This paper provides an overview of the technologies involved, potential medical ben

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Waltz, Margaret, Eric T. Juengst, Teresa Edwards, et al. "The View from the Benches: Scientists' Perspectives on the Uses and Governance of Human Gene-Editing Research." CRISPR Journal 4, no. 4 (2021): 609–15. http://dx.doi.org/10.1089/crispr.2021.0038.

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Nawaz, Sara, and Milind Kandlikar. "Drawing Lines in the Sand? Paths Forward for Triggering Regulation of Gene-Edited Crops." Science and Public Policy 48, no. 2 (2021): 246–56. http://dx.doi.org/10.1093/scipol/scab014.

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Abstract Researchers are making use of new gene-editing techniques in medicine, bioenergy, industrial biotechnology, and beyond, and the field of crop breeding is no exception. These techniques, which differ from genetic modification techniques, spell difficult questions for regulatory oversight: will current rules-of-play apply, or do new techniques necessitate fundamental shifts in regulations? Thus far, little explicit attention has focused on the fundamental yet elusive questions of which technical specifics currently trigger regulation of gene-edited crops, and where different jurisdictio

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Meyer, Morgan, and Cornelius Heimstädt. "The divergent governance of gene editing in agriculture: a comparison of institutional reports from seven EU member states." Plant Biotechnology Reports 13, no. 5 (2019): 473–82. http://dx.doi.org/10.1007/s11816-019-00578-5.

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Choriyeva, Zebiniso. "Genetically modified ecosystems: Innovative approaches in agriculture and their environmental impact." BIO Web of Conferences 149 (2024): 01009. http://dx.doi.org/10.1051/bioconf/202414901009.

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The exploration of genetically modified ecosystems in agriculture has evolved significantly, presenting innovative solutions to global food security challenges while raising ethical, health, and ecological concerns. This literature review critically examines the advancements in genetically modified organisms (GMOs) and their regulatory frameworks, emphasizing their dual role in enhancing agricultural productivity and posing potential risks. Foundational studies highlight biotechnology’s ability to create herbicide-tolerant and insect-resistant crops, significantly reducing reliance on chemical

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Kleiderman, Erika, and Ubaka Ogbogu. "Realigning gene editing with clinical research ethics: What the “CRISPR Twins” debacle means for Chinese and international research ethics governance." Accountability in Research 26, no. 4 (2019): 257–64. http://dx.doi.org/10.1080/08989621.2019.1617138.

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Yi, Hu, and Chen Ye. "Genetic Modification Technology and Food Security: Opportunities, Challenges and Response Strategies." Global Academic Frontiers 3, no. 1 (2025): 11–27. https://doi.org/10.5281/zenodo.15074505.

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Against the background of global population growth, climate change and the increasing tension of arable land resources, how to ensure food security has become a major issue that needs to be addressed by the international community. As an efficient and precise means of genetic modification, transgenic technology has demonstrated remarkable potential in increasing crop yield, enhancing stress resistance and optimising nutritional quality. However, the large-scale application of this technology is still faced with scientific risks such as genetic drift and ecological balance disruption, as well a

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Mollaki, Vasiliki. "Ethical Challenges in Organoid Use." BioTech 10, no. 3 (2021): 12. http://dx.doi.org/10.3390/biotech10030012.

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Organoids hold great promises for numerous applications in biomedicine and biotechnology. Despite its potential in science, organoid technology poses complex ethical challenges that may hinder any future benefits for patients and society. This study aims to analyze the multifaceted ethical issues raised by organoids and recommend measures that must be taken at various levels to ensure the ethical use and application of this technology. Organoid technology raises several serious ethics issues related to the source of stem cells for organoid creation, informed consent and privacy of cell donors,

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Franklin, Sarah. "Developmental Landmarks and the Warnock Report: A Sociological Account of Biological Translation." Comparative Studies in Society and History 61, no. 04 (2019): 743–73. http://dx.doi.org/10.1017/s0010417519000252.

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AbstractAt a crucial meeting during their proceedings, on 9 November 1983, the sixteen members of Britain's influential Warnock Inquiry into Human Fertilisation and Embryology reached a key decision on how to base proposals for comprehensive legislation governing this largely uncharted territory. Famously, they chose the formation of the “primitive streak” in the early embryo as the basis for the fourteen-day rule that has now served as the global benchmark for experimental research in this area for nearly thirty years. Based on newly available archival material and interviews, this article of

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Trompeter, Sara, Shane Grimsley, Anthony Poles, et al. "A National Programme of a High Throughput Axiom Array Genotyping Platform for HEA and HLA Testing for All Patients with Sickle Cell, Thalassaemia and Transfusion Dependent Rare Inherited Anaemias in the United Kingdom." Blood 144, Supplement 1 (2024): 5598. https://doi.org/10.1182/blood-2024-208129.

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In January 2024 the National Health Service (NHS) (NHS England (NHSE) and NHS Blood and Transplant (NHSBT)), launched a programme of typing for 56 Human Erythroid Antigen (HEA) types and Human Leukocyte Antigen (HLA) Class I and II types, at first field resolution by Axiom array genotyping. The test was free at the point of testing, to all patients with sickle cell (SCD), thalassaemia and transfusion dependent rare inherited anaemias in England. This was the clinical deployment of a next version of the Universal Blood Donor Typing array (Gleadall, 2021) developed by the Blood transfusion Genom

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Munjal, Renu. "Role of Artificial Intelligence in transforming agriculture and unveiling new horizons." Journal of Environmental Biology 46, no. 4 (2025): i—ii. https://doi.org/10.22438/jeb/46/4/editorial.

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The agricultural sector, often regarded as the backbone of human civilization, is undergoing a remarkable transformation, thanks to the integration of Artificial Intelligence (AI). With its ability to analyse vast datasets, predict outcomes and automate complex tasks, AI is revolutionizing how we cultivate crops, manage resources, and ensure food security in the face of global challenges.One of the most significant impacts of AI in agriculture is its role in precision farming. AI-powered systems utilize satellite imagery, drones, and sensors to monitor soil conditions, weather patterns, and cr

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Dewi Teresia, Estiani Sinta, and Hermi Hermi. "PENGARUH STRUKTUR KEPEMILIKAN, UKURAN PERUSAHAAN DAN KEPUTUSAN KEUANGAN TERHADAP NILAI PERUSAHAAN DENGAN PERTUMBUHAN PERUSAHAAN SEBAGAI VARIABEL MODERATING." Jurnal Magister Akuntansi Trisakti 3, no. 1 (2016): 73. http://dx.doi.org/10.25105/jmat.v3i1.4969.

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<p>Abukosim, Mukhtaruddin, Ika Sasti Ferina and Claudya Nurcahaya. 2014. Ownership Structure and Firm Value : Empirical Study on Indonesia Manufacturing Listed Company. <em>Journal of Economic</em>. Vol. 5, No. 4.</p><p>Afzal, Arie. 2012. Pengaruh Keputusan Investasi, Keputusan Pendanaan, dan Kebijakan Dividen terhadap Nilai Perusahaan.<em>Skripsi Universitas Diponegoro</em>. Semarang. (tidak dipublikasikan)</p><p>Aries, Heru Prasetyo. 2011. Evaluasi Perusahaan. Jakarta Pusat. PPM.</p><p>Asmawati dan Lailatul Amanah. 2013. Penga

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"“Prevention” and Human Gene Editing Governance." AMA Journal of Ethics 23, no. 1 (2021): E49–54. http://dx.doi.org/10.1001/amajethics.2021.49.

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Shah, Esha, David Ludwig, and Phil Macnaghten. "The complexity of the gene and the precision of CRISPR." Elementa: Science of the Anthropocene 9, no. 1 (2021). http://dx.doi.org/10.1525/elementa.2020.00072.

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The rapid development of CRISPR-based gene editing has been accompanied by a polarized governance debate about the status of CRISPR-edited crops as genetically modified organisms. This article argues that the polarization around the governance of gene editing partly reflects a failure of public engagement with the current state of research in genomics and postgenomics. CRISPR-based gene-editing technology has become embedded in a narrow narrative about the ease and precision of the technique that presents the gene as a stable object under technological control. By tracing the considerably dest

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Peng, Yaojin, Jianwei Lv, Lulu Ding, Xia Gong, and Qi Zhou. "Responsible governance of human germline genome editing in China." Biology of Reproduction, May 27, 2022. http://dx.doi.org/10.1093/biolre/ioac114.

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Abstract Considerable improvements have been made to gene editing technology, which has been increasingly applied to research involving humans. Nevertheless, human heritable germline genome editing is associated with a series of potential ethical, legal, and social risks, which have generated major controversies and discussions worldwide, especially after the “gene-edited babies” incident. Influenced by this incident, China has realized the importance of ethical governance in the field of life science and technology, has accelerated legislative and policy efforts in this field, and has gradual

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Middelveld, Senna, and Phil Macnaghten. "Gene editing of livestock." Elementa: Science of the Anthropocene 9, no. 1 (2021). http://dx.doi.org/10.1525/elementa.2020.00073.

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Gene editing technologies allow users to make in vivo (live) changes to an organism’s DNA. Advances in the field of gene editing have made it arguably more precise, efficient, flexible, and cheaper compared to previous technologies. This has generated an upsurge of interest in gene editing and its governance, including in livestock applications. Although gene editing in livestock promises benefits, it also raises technical, ethical, and societal questions alongside the prospect of (radical) transformation. Since the technology is still to be developed into marketable products, it is the design

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Chen, Long. "Legal Governance of Human Gene Editing Technology: From Single Governance to Multiple Governance." Biotechnology Law Report, October 7, 2024. http://dx.doi.org/10.1089/blr.2024.86733.chen.

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Cwik, Bryan. "Global health and global governance of emerging biomedical technologies." Journal of Medical Ethics, February 7, 2023, jme—2022–108673. http://dx.doi.org/10.1136/jme-2022-108673.

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Global governance of emerging, disruptive biomedical technologies presents a multitude of ethical problems. The recent paper by Shoziet alraises some of these problems in the context of a discussion of what could be themostdisruptive (and most morally fraught) emerging biomedical technology—human germline genome editing. At the heart of their argument is the claim that, for something like gene editing, there is likely to be tension between the interests of specific states in crafting regulation for the technology, and disagreement about what would be necessary to meet the requirements for resp

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Selfa, Theresa, Christopher Cummings, Michael Dahlstrom, et al. "Gene Editing in Agriculture: Social Concerns, Public Engagement, and Governance." Science, Technology, & Human Values, September 3, 2023. http://dx.doi.org/10.1177/01622439231194817.

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Selfa, Theresa, Sonja Lindberg, and Carmen Bain. "Governing gene editing in agriculture and food in the United States." Elementa: Science of the Anthropocene 9, no. 1 (2021). http://dx.doi.org/10.1525/elementa.2020.00153.

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Biotechnologies in agriculture and food are increasingly governed by both state and nonstate actors. In this article, we explore emerging tensions and contestations in the United States over how gene-editing technologies in agriculture and food should be governed and by whom. This article is framed theoretically by the literatures examining the politics of state and nonstate governance of the agrifood and biotechnology sectors. We draw on semistructured interviews with 45 key actors in the United States, including representatives of regulatory agencies, commodity groups, consumer and environme

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Selfa, Theresa, Sonja Lindberg, and Carmen Bain. "Governing gene editing in agriculture and food in the United States." Elementa: Science of the Anthropocene 9, no. 1 (2021). http://dx.doi.org/10.1525/elementa.2020.00153.

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Biotechnologies in agriculture and food are increasingly governed by both state and nonstate actors. In this article, we explore emerging tensions and contestations in the United States over how gene-editing technologies in agriculture and food should be governed and by whom. This article is framed theoretically by the literatures examining the politics of state and nonstate governance of the agrifood and biotechnology sectors. We draw on semistructured interviews with 45 key actors in the United States, including representatives of regulatory agencies, commodity groups, consumer and environme

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Asquer, Alberto, and Michael Morrison. "Editorial: Regulation and governance of gene editing technologies (CRISPR, etc.)." Frontiers in Political Science 4 (September 20, 2022). http://dx.doi.org/10.3389/fpos.2022.1027410.

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Meyer, Morgan, and Frédéric Vergnaud. "The Geographies and Politics of Gene Editing: Framing Debates Across Seven Countries." Frontiers in Political Science 3 (October 25, 2021). http://dx.doi.org/10.3389/fpos.2021.731496.

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This article traces the contours and dynamics of the debates about the politics of gene editing. It does so by providing both a quantitative and qualitative analysis of the publications on the topic. We present a scientometric analysis of scientific publications; we discuss the geographies of gene editing by analysing the scales and spatial terms mobilised; and we undertake a lexicometric analysis of how debates are framed and the public is positioned. Our scientometric analysis of scientific articles shows that the governance and regulation of gene editing is discussed across an increasing ra

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Middelveld, Senna, Phil Macnaghten, and Franck Meijboom. "Imagined futures for livestock gene editing: Public engagement in the Netherlands." Public Understanding of Science, August 1, 2022, 096366252211119. http://dx.doi.org/10.1177/09636625221111900.

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Gene editing is an emerging technology with diverse applications in the making, including in livestock. While the technology is commonly represented as offering unbounded possibilities and societal benefit, it remains unclear how to characterise public views and the process through which responses are developed. Rather than simply being about individual attitudes, beliefs or preferences, we explicate an interpretative approach that seeks to understand how people make sense of the technology in the form of shared cultural idioms and stories. Based on five anticipatory focus group discussions wi

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Mourby, Miranda, Jessica Bell, Michael Morrison, et al. "Biomodifying the ‘natural’: from Adaptive Regulation to Adaptive Societal Governance." Journal of Law and the Biosciences 9, no. 1 (2022). http://dx.doi.org/10.1093/jlb/lsac018.

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Abstract Biomodifying technologies—such as gene editing, induced pluripotent stem cells, and bioprinting—are being developed for a wide range of applications, from pest control to lab-grown meat. In medicine, regulators have responded to the challenge of evaluating modified ‘natural’ material as a therapeutic ‘product’ by introducing more flexible assessment schemes. Attempts have also been made to engage stakeholders across the globe on the acceptable parameters for these technologies, particularly in the case of gene editing. Regulatory flexibility and stakeholder engagement are important, b

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Chen, Yuan, and Xiaoliang Luo. "Reflection on Gene Editing from the Perspective of Biopolitics." NanoEthics 18, no. 1 (2024). http://dx.doi.org/10.1007/s11569-023-00451-4.

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AbstractThe study examines the creation of gene-edited infants from the perspective of biopolitics. Through an analysis at the level of “body-power”, we show that the infants are a product of an advanced stage of biopolitics. On the other hand, considering the level of “space-power”, we indicate that the mechanism of space deepens the governance of population through biopower, leading to real conflicts between past and future in the present. The infants can be seen as “heterotopias of mirrors”, where super-reality replaces the reality, culminating in a rational dilemma. We must also consider h

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Feeney, Oliver, Julian Cockbain, and Sigrid Sterckx. "Ethics, Patents and Genome Editing: A Critical Assessment of Three Options of Technology Governance." Frontiers in Political Science 3 (September 21, 2021). http://dx.doi.org/10.3389/fpos.2021.731505.

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Current methods of genome editing have been steadily realising the once remote possibilities of making effective and realistic genetic changes to humans, animals and plants. To underpin this, only 6 years passed between Charpentier and Doudna’s 2012 CRISPR-Cas9 paper and the first confirmed (more or less) case of gene-edited humans. While the traditional legislative and regulatory approach of governments and international bodies is evolving, there is still considerable divergence, unevenness and lack of clarity. However, alongside the technical progress, innovation has also been taking place i

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Dhai, Ames, Glenda Gray, Martin Veller, and Daynia Ballot. "Governance of gene editing in South Africa: Towards addressing the ethico-legal hiatus." South African Journal of Science 116, no. 5/6 (2020). http://dx.doi.org/10.17159/sajs.2020/7933.

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Chokshi, Krishna, and Daniel Johnson. "The Widespread Ethical Disagreement of CRISPR-Cas9." Journal of Student Research 13, no. 2 (2024). http://dx.doi.org/10.47611/jsrhs.v13i2.6610.

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In the early 21st century, gene therapy, specifically CRISPR-Cas9, was developed as a viable option to prevent heritable diseases and treat genetic disorders in somatic and germline cells. However, the advancement of this technology has led to misuse, as genetic “engineers” aim to alter the DNA of future generations to conform to an idealistic set of standards. The abuse of technology, coupled with the ability to reconstruct an individual’s genetic makeup, leads to the societal question about the best way to regulate this software. This paper addresses three key factors in preventing misuse wh

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Yang, Yao, and Xiaoyong Shi. "International practice and enlightenment for the ethical governance of emerging technologies." Cultures of Science, February 18, 2025. https://doi.org/10.1177/20966083251321285.

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Science and technology (S&T) ethics is the base for promoting the healthy development of S&T, and the governance of emerging technology ethics has become an important part of global S&T ethics governance. This study discusses the ethical governance of leading technologies of the new round of the scientific revolution, such as artificial intelligence, human gene editing and stem cell technology. We analyse the approaches taken by international organizations such as the United Nations, the European Union, the World Health Organization and the International Society for Stem Cell Resea

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Montenegro de Wit, Maywa. "Democratizing CRISPR? Stories, practices, and politics of science and governance on the agricultural gene editing frontier." Elementa: Science of the Anthropocene 8 (January 1, 2020). http://dx.doi.org/10.1525/elementa.405.

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Many trends in agricultural biotechnology have extended fluidly from the first era of genetic modification using recombinant DNA techniques to the era of gene editing. But the high-profile, explicit, and assertive discourse of democratization with gene editing — especially CRISPR-Cas9 — is something new. In this paper, I draw on semi-structured interviews with gene editors, policy analysts, and communications experts as well as with critical academic and civil society experts. I use Science and Technology Studies and political ecology lenses to unpack democratization in three main parts. First

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Nielsen, Jane, Lisa Eckstein, Dianne Nicol, and Cameron Stewart. "Integrating Public Participation, Transparency and Accountability Into Governance of Marketing Authorisation for Genome Editing Products." Frontiers in Political Science 3 (October 15, 2021). http://dx.doi.org/10.3389/fpos.2021.747838.

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Public participation, transparency and accountability are three of the pillars of good governance. These pillars become particularly important for innovative, personalised health technologies, because of the tendency of these technologies to raise distinct scientific, ethical, legal and social issues. Genome editing is perhaps the most personal of all innovative health technologies, involving precise modifications to an individual’s genome. This article focuses on the adequacy of current requirements for public participation, transparency and accountability in the governance of the market auth

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Mongo, Muriel Tapiwa. "Ethical Risk Governance in Biotechnology: A Framework for Bioethics and Risk Analysis." 1, no. 1 (2025): 1–13. https://doi.org/10.5281/zenodo.15430500.

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This article explores the intersection of bioethics and risk analysis in biotechnology, focusing on how ethical frameworks and risk governance can guide responsible innovation in the life sciences. Through real world case studies and policy insights, it examines challenges in areas such as gene editing, biopharmaceuticals, and synthetic biology. The paper advocates for integrative ethical oversight to protect public health, enhance biosafety, and ensure biotech entrepreneurship aligns with societal values. It serves as a critical resource for researchers, policymakers, and entrepreneurs workin

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Li, Jieli. "Governing High-Risk Technologies in a Fragmented World: Geopolitical Tensions, Regulatory Gaps, and Institutional Barriers to Global Cooperation." Fudan Journal of the Humanities and Social Sciences, May 16, 2025. https://doi.org/10.1007/s40647-025-00445-4.

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Abstract The global governance of high-risk technologies—including nuclear technology, artificial intelligence (AI), quantum computing, biotechnology, and gene editing—faces mounting challenges due to geopolitical tensions, regulatory gaps, and institutional barriers. Drawing on sociopolitical theories such as Beck’s Risk Society, Giddens’ Runaway World, and Perrow’s Normal Accidents, this paper examines the complexities of regulating rapidly advancing technologies within a fragmented global landscape. Unlike previous industrial revolutions, today’s technological transformations are unfolding

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Mehlman, Maxwell J., Ronald A. Conlon, and Alex Pearlman. "Governing nonconventional genetic experimentation." Journal of Law and the Biosciences 10, no. 1 (2023). http://dx.doi.org/10.1093/jlb/lsad003.

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Abstract A large and highly heterogeneous group of individuals conducts genetic and genomic research outside of traditional corporate and academic settings. They can be an important source of innovation, but their activities largely take place beyond the purview of existing regulatory systems for promoting safe and ethical practices. Historically the gene-targeting technology available for non-traditional genomic research has been limited, and therefore these activities have attracted little regulatory attention. New technologies such as CRISPR/Cas9, however, give nonconventional experimenters

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