Littérature scientifique sur le sujet « Gedesic »

Cough is one of the most common symptoms of acute respiratory viral infections in childhood. In the treatment of acute respiratory infections accompanied by cough in children, the main task is to stop the cough by improving the rheological properties of bronchial secretions for their early withdrawal. Cough can be effectively treated only by improving the discharge of mucus from the respiratory tract. For this purpose, mucoactive drugs are used: secretolytics, capable of thinning mucus (mucolytic action), and secretomotor drugs, which improve its output (expectorant effect). Among the many mucoactive drugs in pediatrics, preference is given to herbal drugs, which have a milder expectorant effect compared to synthetic drugs, and are better tolerated. On the Ukrainian pharmaceutical market there is Gederin Ivy Syrup, a preparation with ivy extract. Among the complex of effects of the ivy leaf extract (expectorant, secretolytic, anti-inflammatory), the unique action that distinguishes it from other herbal and synthetic drugs is bronchospasmolytic one. Taking this into account, preparations with ivy extract can be recommended for respiratory infections accompanied by obstruction. These can be both acute and chronic conditions occurring with reversible narrowing of the airways. Due to its natural composition, the drug is safe. Side effects from Gederin Ivy syrup are very rare. In patients with hypersensitivity to the components of the drug some allergic reactions (mainly rash), as well as gastrointestinal disorders are possible. It should not be administered to patients suffering from fructose intolerance. Sorbitol, which is a component of the syrup, can cause a slight laxative effect. Thus, the combination of such effects of ivy extract in the preparation Gederin Ivy – expectorant (mucokinetic and secretolytic), bronchospasmolytic and anti-inflammatory – predetermines its expressive clinical efficacy in the treatment of cough, as well as good tolerance. And this allows it to be widely used in the complex therapy of bronchitis in pediatric practice. No conflict of interest was declared by the authors. Key words: Mucoactive phytopreparations, children, treatment, ivy extract, efficacy, safety.

Acute respiratory infections (ARI, commen cold) are the most common infection diseases in children. They account for up 75% of all cases of respiratory diseases. In most cases, ARI are selfterminating diseases that require only symptomatic treatment. The most common symptom of ARI is cough. In outpatient practice justified the use of herbal medicine. As an antisussive well eastablished syrup Gedelix. The effectivnesses of the medicine, the possibility of accuracy dosing, pleasant taste facilitate it use in children.

Acute bronchitis is an infectious inflammatory disease of the lower respiratory tract which occurs at any age. The main symptom of acute bronchitis is non-productive (dry) or productive (wet) cough. The main goal in treating acute bronchitis with productive cough is to increase expectoration, including with the help of mucoactive drugs. In clinical practice, herbal medicines are increasingly used to eliminate symptoms of the disease and to suppress inflammation. The advantage of herbal coughs medicines is that various compounds of herbal ingredients are able to enhance the desired effects and neutralize side effects. Among the numerous expectorant herbal preparations, only a few, namely, preparations of common ivy, thyme and primrose, have the most complex effect: they increase mucus secretion and motility, reduce respiratory tract tone and inhibit inflammation. A comparative pharmacoeconomic analysis of medicines based on ivy extract in the form of syrup which are available on the pharmaceutical market showed that treatment with Gederin Ivy Syrup is the optimal from a pharmacoeconomic point of view. The combination of such effects of ivy extract in the preparation Gederin Ivy, as expectorant (mucokinetic and secretolytic), bronchospasmolytic and anti-inflammatory, predetermines its pronounced clinical efficacy for the treatment of cough, as well as good tolerance, allow it to be widely used in the complex therapy of bronchitis in pediatric practice. The author declares no conflict of interest. Key words: mucoactive phytopreparations, ivy extract, efficiency, safety, economic feasibility.

Studies conducted as part of the Federal target program “Research and Development in Priority Directions for the Development of the Russian Science and Technology Complex for 2014–2020”, showed high efficiency of interaction of calculated norms of mineral fertilizers with modern bioagents RECB-50B, RECB-95B and adaptogenic drugs. At the same time, the actual yield of spring rapeseed of the Gedemin variety exceeds the planned one (3 t/ha) by 9.3–12.3 %, respectively, the chemical load on the environment is reduced and the cost of production of oilseeds is reduced.