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Thèses sur le sujet « Functional delivery »

Auteur : Grafiati

Publié le 29 mars 2025

Mis à jour le 31 juillet 2025

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1

Alexander, Shirin. "Multi functional polymers for drug delivery." Thesis, University of Bristol, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.566691.

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Amphiphilic block and graft copolymers have been studied because of the possibility of tailoring their complex and fascinating chemical properties. Potential applications include wetting agents, foaming agents, plastic modifiers as well as biomedical applications in drug delivery, owing to their biocompatible and low toxic nature. This thesis describes the study of a series of amphiphilic block copolymers, known as Pluronics, and their aqueous interaction with a hydrophobic drug, flurbiprofen. Synthesis and characterisation of novel graft copolymers with interesting associative behaviour that

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Siva, Sahithi Pokala. "Design and delivery : functional colour web pages." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343620.

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3

Zhang, Chengxiang. "Functional Conjugates for Drug and Gene Delivery." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu158703024326976.

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4

Kilsby, Samuel. "Functional polyesters for drug delivery and 3D printing." Thesis, Loughborough University, 2016. https://dspace.lboro.ac.uk/2134/20177.

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Funtional εCL monomers have been successfully synthesised utilising a primary amine (protected as a CBZ or BOC carbamate) and also a protected ketone (using an acetal protecting group). Amine derivatives were synthesised from the commercially available trans-4-aminocyclohexanol. The acetal protected ketone was synthesised from the commercially available 1,4-cyclohexanedione monoethylene acetal. The subsequent exposure of these monomers to ring opening polymerisation conditions (using stannous octanoate) in the presence of εCL, yielded random copolymers with a functionalised polyester backbone.

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5

Bansode, Ratnadeep Vitthal. "Functional ionic liquids in crystal engineering and drug delivery." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14563.

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The objective of this research is to explore the use of ionic liquds in crystal engineering and drug delivery. Ionic liquids have a wide range of applications in pharmaceutical field due to their unique physicochemical propertie ssuch as chemical, thermal stability, low melting point, nonvolatility, nonflamability, low toxicity and recyclability which offer unique and interesting potential for pharmaceuitcal applications. Currently, many research groups are working on the development of ionic liquids to use in this field but there is need to develop systematic understanding about new technique

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Bansode, Ratnadeep V. "Functional ionic liquids in crystal engineering and drug delivery." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14563.

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The objective of this research is to explore the use of ionic liquds in crystal engineering and drug delivery. Ionic liquids have a wide range of applications in pharmaceutical field due to their unique physicochemical propertie ssuch as chemical, thermal stability, low melting point, nonvolatility, nonflamability, low toxicity and recyclability which offer unique and interesting potential for pharmaceuitcal applications. Currently, many research groups are working on the development of ionic liquids to use in this field but there is need to develop systematic understanding about new technique

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7

Wright, Ruvimbo Pearl. "Soysomes and Other Functional Biomaterials from Sucrose Soyate Derivatives." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/29872.

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Biomaterials serve as interventional tools in medicine to treat, improve or replace diseased tissues, organs or function of the body. Although several polymeric biomaterials already exist, they often present challenges, at material level, such as non-biodegradability, degradation into acidic by-products or tissue incompatibility, or at functional level such as failure to sustain prolonged release of therapeutic payload for a desired period. Research has been focused on investigating new polymeric candidates to address these problems of current systems. The use of renewable resources to generat

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8

Haag, Shannon S. "Effects of response-independent stimulus delivery and functional communication training." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2613.

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Thesis (M.A.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains viii, 38 p. : ill. Includes abstract. Includes bibliographical references (p. 33-37).

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9

Probert, John Michael. "Functional nano-particles derived from dendrimer derivatisation and self-assembly." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266664.

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10

Li, Zhenqing. "Development of Multi-functional Stem Cell Delivery Systems for Cardiac Therapy." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337223886.

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11

NAIRI, VALENTINA. "Functional ordered mesoporous silica in nanomedicine: target and drug delivery systems." Doctoral thesis, Università degli Studi di Cagliari, 2018. http://hdl.handle.net/11584/255981.

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Ordered mesoporous materials (OMMs) are characterized by high surface area (up to 1000 m2/g), high pore volume (1-3 cm3/g) and narrow pore size (2-30 nm) distribution. Recently, mesoporous silica nanoparticles (MSNs), a subclass of OMMs, have had great development as nanocarriers for drug delivery, particularly for cancer treatment. The research activity of my PhD work was aimed to study SBA-15 and MCM-41 mesoporous silica samples for biomedical applications. The texture and the structure of the synthesized materials were characterized through N2 adsorption/desorption isotherms, SAXS, and TEM.

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12

Wang, Qi. "Synthesis of multi-functional dendrimers for targeted delivery of nucleic acids." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4068/document.

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Nous avons démontré que structurellement flexibles poly(amidoamine) (PAMAM) dendrimères sont efficaces système de livraison de siRNA in vitro et in vivo récemment. Nous voulons mener une enquête plus approfondie sur la livraison de siRNA ciblés en utilisant des dendrimères conjugués avec des ligands spécifiques ou d'anticorps, qui peuvent reconnaître les récepteurs correspondants ou des protéines exprimées à la surface des cellules. De cette façon, le siRNA peuvent être livrés spécifiquement aux cellules d'intérêt, conduisant à une délivrance ciblée, ce qui peut améliorer l'efficacité livraiso

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13

Wang, Qi. "Synthesis of multi-functional dendrimers for targeted delivery of nucleic acids." Electronic Thesis or Diss., Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4068.

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Nous avons démontré que structurellement flexibles poly(amidoamine) (PAMAM) dendrimères sont efficaces système de livraison de siRNA in vitro et in vivo récemment. Nous voulons mener une enquête plus approfondie sur la livraison de siRNA ciblés en utilisant des dendrimères conjugués avec des ligands spécifiques ou d'anticorps, qui peuvent reconnaître les récepteurs correspondants ou des protéines exprimées à la surface des cellules. De cette façon, le siRNA peuvent être livrés spécifiquement aux cellules d'intérêt, conduisant à une délivrance ciblée, ce qui peut améliorer l'efficacité livraiso

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14

Fernandes, Alinda. "Lentiviral-mediated gene delivery to investigate the functional role of neuropsychiatric genes." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/lentiviralmediated-gene-delivery-to-investigate-the-functional-role-of-neuropsychiatric-genes(b6392e47-e94b-4e64-b343-e7eafd696b26).html.

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Genetic studies have led to the identification of several candidate genes, some novel and others established, that may contribute to the risk of developing neuropsychiatric disorders. For example, dopamine receptor genes are established candidates for a number of psychiatric disorders such as Parkinson’s Disease, alcohol addiction and mood disorders. On the other hand, a gene of unknown function, AUTS2 (Autism susceptibility candidate 2), has recently been associated with alcohol consumption in a GWAS meta-analysis performed by our group. Interestingly, it has been associated with a broad rang

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15

Levy, Charlotte Luanne Victoria. "Nanoporous calcium carbonate-based substrates for the controlled delivery of functional materials." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/9288.

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The overall aim of this project was to study 'functionalised' calcium carbonates (FCCs) for use as a carrier for the controlled release of 'actives,' by permeation and diffusion, and is being proposed as an environmentally friendly and non-toxic pharmaceutical excipient, nutraceutical, and flavour carrier. The delivery of a drug to its target site in the appropriate amount and time-frame in order for it to have a controlled release effect whilst achieving the maximum therapeutic effect remains a topic of design and development for novel drug delivery systems. FCCs encompass a family of new pha

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16

Keshwan, Abdulmohsin. "Utilising cross-functional teams to achieve marketing/operations integration for delivery priority." Thesis, University of Salford, 2016. http://usir.salford.ac.uk/40450/.

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In today's manufacturing environment, due to the complexity of products, and the progress of technology, organisations are forced to be more responsive to the pressure of the dynamic market by developing, producing and delivering products quickly and before competitors (Bendoly et al., 2012; Gattiker, 2007). As a result, the integration between marketing and operations as core functions of a manufacturing organisation (Slack et al., 2013) has increasingly received attention from many academics and practitioners (e.g., Hausman et al., 2002; O’Leary-Kelly & Flores, 2002; Prabhaker, 2001; Swink &

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17

Nelson, Ashley M. "Design of Functional Polyesters for Electronic and Biological Applications." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/74914.

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Melt polymerization and novel monomers enabled the synthesis of polyesters for electronic and biological applications. Inspiration from nature and a passion for environmental preservation instigated an emphasis on the incorporation of renewable resources into polymeric materials. Critical analysis of current research surrounding bisphenol-A replacements and ioncontaining segmented polyurethanes aided in identifying benchmark polymers, including limitations, challenges, and future needs. Structure-property-morphology relationships were investigated to evaluate the polymers for success in the pr

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18

Shanbhag, Mihir S. Wheatley Margaret A. "Development of a multi-functional construct for central nervous system repair /." Philadelphia, Pa. : Drexel University, 2008. http://hdl.handle.net/1860/2906.

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19

Errico, Claudia. "Ultrasound sensitive agents for transcranial functional imaging, super-resolution microscopy and drug delivery." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC013.

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Cette thèse porte sur deux branches majeures de l'utilisation d'agents sensibles aux ultrasons: l'échographie ultrarapide du cerveau assistée par microbulles et la délivrance par ultrasons de médicaments pour la thérapie du cancer. Dans la première approche, des microbulles remplies de gaz fluoré ont été utilisés pour observer l'activation du cerveau à travers le crâne des rongeurs. Nous avons été en mesure de reconstituer de manière non invasive le réseau vasculaire du cerveau, puis de récupérer sa réponse hémodynamique avec une résolution spatio-temporelle élevée. La validation de cette appr

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20

Smith, Meghan Elisabeth. "Biologically Functional Scaffolds for Tissue Engineering and Drug Delivery, Produced through Electrostatic Processing." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1251224066.

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Thesis(Ph.D.)--Case Western Reserve University, 2010<br>Title from PDF (viewed on 2009-12-30) Department of Chemical Engineering Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center

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21

Huang, Wei-Pang. "Functional analysis of Aut7 in vacuolar delivery of aminopeptidase I in Saccharomyces cerevisiae /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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22

CURTO, M. D. DEL. "ORAL DELIVERY SYSTEMS INTENDED FOR COLONIC RELEASE OF INSULIN AND SELECTED FUNCTIONAL ADJUVANTS." Doctoral thesis, Università degli Studi di Milano, 2009. http://hdl.handle.net/2434/152826.

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Abstract of the PhD thesis entitled “Oral delivery systems intended for colonic release of insulin and selected functional adjuvants” Colon delivery has gained increased attention as a potential approach to improve the oral bioavailability of peptides and proteins. In this respect, the suitability of a previously developed release platform (ChronotopicTM) was explored for the conveyance of insulin and selected functional adjuvants. The system consists of a drug core and a swellable/erodible hydroxypropyl methylcellulose (HPMC) release-controlling coating. When an outer enteric film is a

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23

Yang, Xia. "Multi-functional Hyaluronan Based Biomaterials for Biomedical Applications." Doctoral thesis, Uppsala universitet, Polymerkemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224371.

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This thesis presents strategies for constructing multi-functional biomaterials based on hyaluronan (HA) derivatives for various biomedical applications, such as drug delivery, tissue regeneration, and imaging biomaterials. The aim of this study is to improve the functionalities of HA biomaterials as well as simplify the preparation procedures. Native HA polymer contains D-glucuronic acid residue with a carboxyl group per disaccharide unit that can be easily modified by carbodiimide-mediated amidation reaction. Therefore, we have designed a series of orthogonal groups (hydrazide, carbazate, al

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24

Dupont, Kenneth Michael. "Human stem cell delivery and programming for functional regeneration of large segmental bone defects." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39647.

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Large bone defects pose a significant clinical challenge currently lacking an adequate therapeutic solution. Bone tissue engineering (BTE) therapies aim to provide that solution by combining structural scaffolds, bioactive factors, and/or osteogenic cells. Cellular therapies are likely vital to repair severe defects in patients lacking sufficient endogenous cells. Stem cells are attractive cell choices due to their osteogenic differentiation and extensive proliferation abilities, but their therapeutic potential is still uncertain, as studies comparing stem cell sources and delivery methods

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25

Manson, Joanne. "PLGA films containing poly(ethylene glycol) functional gold nanoparticles for potential drug delivery applications." Thesis, University of Ulster, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557399.

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In this study novel composites comprising poly(ethylene glycol) functionalised gold nanoparticles (PEG-AuNP) dispersed within a poy(DL-Iactic-co-glycolic) (PLGA) film were produced via a solvent-casting technique and their effect on the degradation of PLGA investigated. In addition to the release profile of AuNPs during degradation was studied. The production of PLGA films containing PEG-AuNPs is a first step proof-of-principle concept for the aim of producing a composite capable of both targeted and sustained drug delivery. PLGA films were produced via solvent-casting using a number of molecu

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26

Vabbilisetty, Pratima. "Functional Anchoring Lipids for Drug Delivery Carrier Fabrication and Cell Surface Re-Engineering Applications." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1424175323.

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27

Nichols, Sarah, Nathan Justice, Anjali Malkani, and David Wood. "The Path(way) to a Clean Colon: Improving the Management of Functional Constipation." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/42.

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Title: The path(way) to a clean colon: Improving the management of functional constipation Authors: Sarah Nichols, D.O. Pediatrics Resident, Nathan Justice, M.D. Pediatrics Hospital Medicine, Anjali Malkani, M.D. Pediatric Gastroenterology, David Wood, M.D., MPH General Pediatrics and Adolescent Medicine Purpose / Objectives: Hospitalization for the treatment of functional constipation is a leading cause among encounters that incur a financial loss at our institution. There are few resources that describe best practices or quality improvement efforts in the management of children who are hospi

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Clemente, Ilaria. "Compartmentalized algal-based nanocarriers as vectors for antioxidants: structural and functional characterization." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1193669.

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The delivery of poorly water-soluble natural drugs is a longtime challenge that has led to the development of several solubilizing and encapsulating carrier systems, to administrate hydrophobic molecules for biomedical, pharmaceutical, food and cosmetics applications. Among the most popular soft matter nanocarriers, lipid-based vectors are particularly favored thanks to the advantageous properties of lipids used as versatile and biocompatible building blocks. Indeed, lipids are the class of bio-macromolecules with the richest polymorphism and spontaneous self-assembly character, that result i

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Lee, Hyun-Jung. "Delivery of thermostabilized chondroitinase ABC enhances axonal sprouting and functional recovery after spinal cord injury." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31734.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Ravi V. Bellamkonda; Committee Member: Andreas Bommarius; Committee Member: Andrés J. García; Committee Member: Niren Murthy; Committee Member: Robert J. McKeon. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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Xu, Zhenhua, and 许振华. "Functional characterization of cell cycle-related kinase in glioblastoma and development of gene delivery system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47752658.

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Cell cycle-related kinase (CCRK) is a 42 KDa serine/threonine protein kinase homologous to Cdk1, 2 and 7. Previous work has shown that CCRK regulates cell cycle transition by phosphorylating Cdk2 and Rb. More importantly, it was found that CCRK was a candidate oncogene in both glioblastoma multiform (GBM) and human colorectal cancer. However, the mechanistic role of CCRK in tumorigenicity is still not completely understood. In the first part of this thesis, I found that casein kinas II beta (CKIIβ) was one of proteins that interact with CCRK using the high-throughput yeast-two-hybrid

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31

Gulfam, Muhammad. "Development of functional micelles from biodegradable amphiphilic block copolymers for drug delivery and tumour therapy." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47106/.

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Drug delivery systems in the size range of ~ 10-250 nm are enabling tools for site-specific targeting and controlled release applications. To take advantage of these capabilities, various nanocarriers e.g., micelles, dendrimers, liposomes, nanoparticles, nanocapsules, nanotubes, and nanogels, have been designed for drug delivery. Specifically, micelle-based drug carrier systems have emerged as promising tools for site-specific delivery and controlled release applications. Despite several advantages over conventional drugs, some limitations of micelle-based drug delivery have also been reported

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Riddle, Ryan T. "Maximizing sulforaphane delivery and sensory acceptability of a novel soy-tomato-broccoli sprout beverage." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1323373292.

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Liang, Ya Palmese Giuseppe R. Lowman Anthony M. "Functional polymer-polymer composites by nano/meso-fiber encapsulation : applications in drug delivery systems and polymer toughening /." Philadelphia, Pa. : Drexel University, 2010. http://hdl.handle.net/1860/3316.

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McKee, Deloyce A. "Assessing the background and training for delivery of functional behavior assessment at the application level in Kansas /." Search for this dissertation online, 2006. http://wwwlib.umi.com/cr/ksu/main.

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35

He, Wei. "Dual-functional polyurea microcapsules for chronic wound care dressings: sustained drug delivery and non-leaching infection control." John Wiley and Sons, 2012. http://hdl.handle.net/1993/8443.

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A new design of dual-functional polyurea microcapsules was proposed for chronic wound dressings to provide both non-leaching infection control and sustained topical drug delivery functionalities. Quaternary ammonium functionalized polyurea microcapsules (MCQs) were synthesized under mild conditions through an interfacial crosslinking reaction between branched polyethylenimine (PEI) and 2,4-toluene diisocyanate (TDI) in a dimethylformamide/cyclohexane emulsion. An in-situ modification method was developed to endow non-leaching surface antimicrobial properties to MCQs via bonding antimicrobial s

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Schneider, Anselm Fabian Lowell [Verfasser]. "Novel Cell-Penetrating Peptides in the Delivery of Functional Protein Conjugates Into Living Cells / Anselm Fabian Lowell Schneider." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1229917306/34.

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Lee, Cen Ying. "Integrative Trust-Based Functional Contracting: A Complementary Contractual Approach to BIM-Enabled Oil And Gas EPC Project Delivery." Thesis, Curtin University, 2019. http://hdl.handle.net/20.500.11937/75059.

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The research has successfully bridged the gap between contractual and technological practices for the Engineering, Procurement and Construction (EPC) contracts in oil and gas projects. It has identified the related Building Information Modelling (BIM) uses and developed an integrative trust-based functional contracting that complement to EPC contracts. The research contributes to new functional perspectives of contracting and also provides significant insights into the proper use contract functions for improving BIM-enabled projects’ performance.

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Uesaka, Akihiro. "Precise Structural and Functional Control of Molecular Assemblies Composed of Amphiphilic Peptides Having a Hydrophobic Helical Block." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199273.

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Myers, Meredith R. Myers. "Comparison of Consumer Acceptance, Physico-chemical Properties, and Bioactive Delivery of Blueberry Extract and Whole Blueberry Powder Confections." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531490769497695.

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Khan, Md Arif. "NANOHARVESTING AND DELIVERY OF BIOACTIVE MATERIALS USING ENGINEERED SILICA NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/110.

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Mesoporous silica nanoparticles (MSNPs) possess large surface areas and ample pore space that can be readily modified with specific functional groups for targeted binding of bioactive materials to be transported through cellular barriers. Engineered silica nanoparticles (ESNP) have been used extensively to deliver bio-active materials to target intracellular sites, including as non-viral vectors for nucleic acid (DNA/RNA) delivery such as for siRNA induced interference. The reverse process guided by the same principles is called “nanoharvesting”, where valuable biomolecules are carried out and

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41

Burberry, Diane. "LOW COST PRODUCTION OF PROINSULIN IN TOBACCO AND LETTUCE CHLOROPLASTS FOR INJECTABLE OR ORAL DELIVERY OF FUNCTIONAL INSULIN AND." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2148.

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Current treatment for type I diabetes includes delivery of insulin via injection or pump, which is highly invasive and expensive. The production of chloroplast-derived proinsulin should reduce cost and facilitate oral delivery. Therefore, tobacco and lettuce chloroplasts were transformed with the cholera toxin B subunit fused with human proinsulin (A, B, and C peptides) containing three furin cleavage sites (CTB-PFx3). Transplastomic lines were confirmed for site-specific integration of transgene and homoplasmy. Old tobacco leaves accumulated proinsulin up to 47% of total leaf protein (TLP). O

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Theune, Loryn Elisabeth [Verfasser]. "Thermo-Responsive Nanogels as Versatile Platform for Smart Drug Delivery Systems and Multi-Functional Photothermal Agents / Loryn Elisabeth Theune." Berlin : Freie Universität Berlin, 2020. http://d-nb.info/1212031814/34.

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43

Boehm, Michael. "EXPERIMENTAL INVESTIGATION OF TWO-PHASE PENETRATING FLOW OF NEWTONIAN AND NON-NEWTONIAN POLYMERIC FLUIDS AND DEVELOPMENT OF PRACTICAL APPLICATIONS IN DRUG/GENE DELIVERY." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253548237.

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44

Mindemark, Jonas. "Functional Cyclic Carbonate Monomers and Polycarbonates : Synthesis and Biomaterials Applications." Doctoral thesis, Uppsala universitet, Polymerkemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-169677.

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The present work describes a selection of strategies for the synthesis of functional aliphatic polycarbonates. Using an end-group functionalization strategy, a series of DNA-binding cationic poly(trimethylene carbonate)s was synthesized for application as vectors for non-viral gene delivery. As the end-group functionality was identical in all polymers, the differences observed in DNA binding and in vitro transfection studies were directly related to the length of the hydrophobic poly(trimethylene carbonate) backbone and the number of functional end-groups. This enabled the use of this polymer

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45

Glanz, Maria. "Chemoselective conjugation of biological active peptides to functional scaffolds." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20223.

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Peptide bilden eine einzigartige Klasse von Biomolekülen. Auf Grund ihrer komplexen Struktur sind sie in der Lage hochspezifisch an Zielmoleküle zu binden und können darüber hinaus bioaktive Eigenschaften aufweisen. In dieser Dissertation wurden verschiedene Anwendungen, für die biologisch aktive Peptide genutzt werden können untersucht und darüber hinaus die Konjugation ungeschützter Peptide an funktionelle Gerüstmoleküle betrachtet. Die spezifischen Bindungseigenschaften eines Hemagglutinin bindenden Peptids konnten durch deren multivalente Präsentation auf einem Polymer-Nanopartikel genutzt

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Villar, Gabriel. "Aqueous droplet networks for functional tissue-like materials." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:602f9161-368c-48c0-9619-7974f743f2f2.

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An aqueous droplet in a solution of lipids in oil acquires a lipid monolayer coat, and two such droplets adhere to form a bilayer at their interface. Networks of droplets have been constructed in this way that function as light sensors, batteries and electrical circuits by using membrane proteins incorporated into the bilayers. However, the droplets have been confined to a bulk oil phase, which precludes direct communication with physiological environments. Further, the networks typically have been assembled manually, which limits their scale and complexity. This thesis addresses these limitat

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Kasper, Marc-André. "Chemoselective synthesis of functional drug conjugates." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/20870.

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In der vorliegenden Arbeit wird eine modulare Reaktionssequenz von zwei aufeinanderfolgenden chemoselektiven Umwandlungen vorgestellt: Es wird gezeigt, dass Vinyl- und Ethynylphosphonamidate chemoselektiv mit Cysteinen von Proteinen und Antikörpern reagieren. Weiterhin wird gezeigt, dass elektrophile Phosphonamidate durch eine vorhergehende chemoselektive Staudinger-Phosphonit Reaktion zwischen Aziden und ungesättigten Phosphoniten in das gewünschte Molekül eingebaut werden können. Hierbei wird ein elektronenreiches Phosphonit in ein elektronenarmes Phosphonamidat umgewandelt, welches somit fü

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Yang, Xin. "Evaluation of neurochemical and functional effects of glial cell-derived neurotrophic factor gene delivery using a tetracycline-regulatable adeno-associated viral vector." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209984.

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Gene transfer to the brain is a promising therapeutic strategy for a variety of neurodegenerative disorders including Parkinson‟s disease (PD). PD is the second most common neurodegenerative disease. Although many drugs have been developed and introduced into the market to provide symptomatic treatment, there is still no cure for PD. Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for injured nigrostriatal dopamine neurons and is currently being evaluated as a potential treatment for PD. Gene therapy allows localized, long-term and stable transgene expression aft

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Diarrassouba, Fatoumata. "Interactions between ß-lactoglobulin and nutraceutical ligands riboflavin, vitamin D3 and lysozyme Formation, physico-chemical and biological characterization of functional delivery scaffolds." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/30500/30500.pdf.

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La protéine majeure du lactosérum, la β-lactoglobuline (βlg) est bien reconnue pour ses propriétés structurales intéressantes lui permettant d’établir des interactions avec des ligands de taille et de caractéristiques différentes. La riboflavine (RF) et la vitamine D3 (D3) ont été sélectionnées comme modèles de petits nutraceutiques amphiphiles et hydrophobes, respectivement, et le lysozyme (Lyso), comme ligand protéique de plus grande taille. La capacité de la βlg à lier la RF a été étudiée par des méthodes spectroscopiques. La βlg et la RF forment le complexe βlg-RF dont la photoactivation g

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Diarrassouba, Fatoumata. "Interactions between ß-lactoglobulin and nutraceutical ligands riboflavin, vitamin D₃ and lysozyme : formation, physico-chemical and biological characterization of functional delivery scaffolds." Doctoral thesis, Université Laval, 2013. http://hdl.handle.net/20.500.11794/22672.

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La protéine majeure du lactosérum, la β-lactoglobuline (βlg) est bien reconnue pour ses propriétés structurales intéressantes lui permettant d’établir des interactions avec des ligands de taille et de caractéristiques différentes. La riboflavine (RF) et la vitamine D3 (D3) ont été sélectionnées comme modèles de petits nutraceutiques amphiphiles et hydrophobes, respectivement, et le lysozyme (Lyso), comme ligand protéique de plus grande taille. La capacité de la βlg à lier la RF a été étudiée par des méthodes spectroscopiques. La βlg et la RF forment le complexe βlg-RF dont la photoactivation g

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