Littérature scientifique sur le sujet « Folate receptor α »
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Articles de revues sur le sujet "Folate receptor α"
Boss, Silvan D., et Simon Mensah Ametamey. « Development of Folate Receptor−Targeted PET Radiopharmaceuticals for Tumor Imaging—A Bench-to-Bedside Journey ». Cancers 12, no 6 (9 juin 2020) : 1508. http://dx.doi.org/10.3390/cancers12061508.
Texte intégralHøier-Madsen, Mimi, Jan Holm et Steen I. Hansen. « α Isoforms of soluble and membrane-linked folate-binding protein in human blood ». Bioscience Reports 28, no 3 (1 juin 2008) : 153–60. http://dx.doi.org/10.1042/bsr20070033.
Texte intégralScaranti, Mariana, Elena Cojocaru, Susana Banerjee et Udai Banerji. « Exploiting the folate receptor α in oncology ». Nature Reviews Clinical Oncology 17, no 6 (9 mars 2020) : 349–59. http://dx.doi.org/10.1038/s41571-020-0339-5.
Texte intégralBremer, Ryan E., Tatiana S. Scoggin, Elizabeth B. Somers, Daniel J. O'Shannessy et David E. Tacha. « Interobserver Agreement and Assay Reproducibility of Folate Receptor α Expression in Lung Adenocarcinoma : A Prognostic Marker and Potential Therapeutic Target ». Archives of Pathology & ; Laboratory Medicine 137, no 12 (9 avril 2013) : 1747–52. http://dx.doi.org/10.5858/arpa.2013-0039-oa.
Texte intégralBartouskova, Marie, Bohuslav Melichar et Beatrice Mohelnikova-Duchonova. « Folate receptor : a potential target in ovarian cancer ». Pteridines 26, no 1 (1 mars 2015) : 1–12. http://dx.doi.org/10.1515/pterid-2014-0013.
Texte intégralMiotti, S., M. Bagnoli, A. Tomassetti, M. I. Colnaghi et S. Canevari. « Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1 ». Journal of Cell Science 113, no 2 (15 janvier 2000) : 349–57. http://dx.doi.org/10.1242/jcs.113.2.349.
Texte intégralNogueira, Eugénia, Marisa P. Sárria, Nuno G. Azoia, Egipto Antunes, Ana Loureiro, Diana Guimarães, Jennifer Noro, Alexandra Rollett, Georg Guebitz et Artur Cavaco-Paulo. « Internalization of Methotrexate Conjugates by Folate Receptor-α ». Biochemistry 57, no 49 (19 novembre 2018) : 6780–86. http://dx.doi.org/10.1021/acs.biochem.8b00607.
Texte intégralCagle, Philip T., Qihui “Jim” Zhai, Linda Murphy et Philip S. Low. « Folate Receptor in Adenocarcinoma and Squamous Cell Carcinoma of the Lung : Potential Target for Folate-Linked Therapeutic Agents ». Archives of Pathology & ; Laboratory Medicine 137, no 2 (1 février 2013) : 241–44. http://dx.doi.org/10.5858/arpa.2012-0176-oa.
Texte intégralKim, Hye Won, Yun Jung Choi, Ki Nam Kim, Tsunenobu Tamura et Namsoo Chang. « Effect of paternal folate deficiency on placental folate content and folate receptor α expression in rats ». Nutrition Research and Practice 5, no 2 (2011) : 112. http://dx.doi.org/10.4162/nrp.2011.5.2.112.
Texte intégralSamodelov, Sophia L., Zhibo Gai, Gerd A. Kullak-Ublick et Michele Visentin. « Renal Reabsorption of Folates : Pharmacological and Toxicological Snapshots ». Nutrients 11, no 10 (2 octobre 2019) : 2353. http://dx.doi.org/10.3390/nu11102353.
Texte intégralThèses sur le sujet "Folate receptor α"
Sivakumaran, Suneethi. « Role of Androgen Receptor in Folate Receptor α Regulation and in Prostate Cancer ». University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1345570201.
Texte intégralAMBROSI, Emanuele. « Expression, purification and structural characterization of three human proteins : apolipoprotein M, heme-binding protein 2 and folate receptor α ». Doctoral thesis, 2008. http://hdl.handle.net/11562/337640.
Texte intégralThis thesis work was aimed at the expression, purification and crystallization of three human proteins (apolipoprotein M, folate receptor α and SOUL protein) in order to determine their three-dimensional structure by means of X-ray protein crystallography. Human apolipoprotein M was expressed using the methylotrophic yeast P. pastoris. The recombinant protein was purified by ion-exchange chromatography, preparative isoelectric focusing, gel filtration, and Lipidex-1000 chromatography. In order to obtain a more homogeneous protein, the non-glycosylated mutant (Asn135Gln) was also expressed and purified. The crystallization trials gave some positive results with mutated apoM, although the crystals are still not suitable for X-ray diffraction experiments. The heterologous expression of the human FR-a was troublesome, and although different expression systems (P. pastoris, baculovirus, and N. benthamiana) were tested, only a low amount of recombinant protein was obtained (from P. pastoris) and purified (by ion-exchange chromatography and gel filtration). However non of the crystallization conditions tested was successful, probably due to the low protein concentration. Human SOUL (heme-binding protein 2) was expressed in E. coli and purified by immobilized metal ion affinity chromatography, using the hexa-histidine tag added to the C-terminus of the protein. The recombinant SOUL was crystallized both as apoprotein and as a complex in the presence of hemin. The preliminary X-ray diffraction analysis shows the presence of six molecules in the unit cell, and no significant differences between the apoand the holoprotein were found. Further studies suggest that hemin is not bound to the protein, since the Fe peak could not be found in the X-ray fluorescence spectrum of the crystals. Attempts to solve the three-dimensional structure by means of multiple isomorphous replacement, multiwavelength anomalous diffraction and molecular replacement are still in progress.
Chapitres de livres sur le sujet "Folate receptor α"
Ng, Chau H. M., et Ann L. Jackman. « Potential for α-Folate Receptor-Targeted Treatment for Ovarian Cancer ». Dans Emerging Therapeutic Targets in Ovarian Cancer, 245–58. New York, NY : Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-7216-3_12.
Texte intégralMishra, Brahmeshwar, et Sathish Thokala. « Multifunctional Nanocarrier Systems for Effective Delivery of Drugs in Cancer Treatment ». Dans Multifunctional Nanocarriers for Contemporary Healthcare Applications, 301–27. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-4781-5.ch011.
Texte intégralActes de conférences sur le sujet "Folate receptor α"
O'Shannessy, Daniel J., Elizabeth B. Somers, Yao-Shi Fu, Robert Smale, Robert P. Thiel et Nicholas C. Nicolaides. « Abstract 2516 : Immunohistochemical characterization of a novel, highly sensitive monoclonal antibody to folate receptor α ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2516.
Texte intégralYazaki, Shu, Yohei Chiba, Yuki Kojima, Hiroshi Yoshida, Shigemasa Takamizawa, Rui Kitadai, Ayumi Saito et al. « 2022-RA-629-ESGO Association of folate receptor α expression and tumor immune microenvironment in patients with cervical cancer ». Dans ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.39.
Texte intégralNg, Chau HM, Melanie Valenti, Ruth Ruddle, Florence Raynaud, Davinder S. Theti, Fraser Mitchell et Ann L. Jackman. « Abstract 2544 : Preclinical pharmacodynamics (PD) of ONX 0801, a folate receptor-α (FRα) and tumor-targeted thymidylate synthase (TS) inhibitor ». Dans Proceedings : AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011 ; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2544.
Texte intégralAb, Olga, Laura M. Bartle, Xiuxia Sun, Rui Wu, Holly A. Johnson, Kathleen R. Whiteman, Alyssa LaBelle et Victor S. Goldmacher. « Abstract 667 : IMGN853, a folate receptor (FR) α-targeting antibody-drug conjugate (ADC), is highly effective against xenograft models with clinically relevant levels of receptor expression ». Dans Proceedings : AACR Annual Meeting 2014 ; April 5-9, 2014 ; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-667.
Texte intégralFittall, Matthew W., Anthony Cheung, Gyula M. Petranyi, Diana Rodriguez-Dominguez, Heather J. Bax, Panagiotis Karagiannis, Kristina M. Ilieva, Andrew Tutt et Sophia N. Karagiannis. « Abstract A090 : Exploring folate receptor α immunotherapy of breast carcinomas : Human monocytic cell-mediated killing triggered by IgG1 and IgE antibodies ». Dans Abstracts : CRI-CIMT-EATI-AACR Inaugural International Cancer Immunotherapy Conference : Translating Science into Survival ; September 16-19, 2015 ; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6074.cricimteatiaacr15-a090.
Texte intégralQiu, Qifeng, Rui Wu, Leanne Lanieri, Erin Maloney, Anna Skaletskaya, Shan Jin, Lintao Wang et al. « Abstract 71 : Bystander activity andin vivoefficacy of a folate receptor α (FRα)-targeting antibody-drug conjugate with a novel peptide linker ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-71.
Texte intégralLu, Yingjuan, Theresa P. Johnson, Leroy W. Wheeler, Alex M. Lloyd, Vicky A. Cross, Elaine M. Westrick, Nikki L. Parker et Christopher P. Leamon. « Abstract 3670 : Treatment of epithelial ovarian cancer with folate receptor (α/β) targeted chemotherapy is enhanced by CTLA-4 blockade : Learning from animal models ». Dans Proceedings : AACR Annual Meeting 2017 ; April 1-5, 2017 ; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-3670.
Texte intégralCherian, Christina, Lei Wang, Adrianne Wallace, Steven Orr, Zhanjun Hou, Aleem Gangjee et Larry H. Matherly. « Abstract 2706 : Tumor-targeting with novel pyridyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor (FR) α and the proton-coupled folate transporter (PCFT) and inhibition ofde novopurine nucleotide biosynthesis ». Dans Proceedings : AACR Annual Meeting 2014 ; April 5-9, 2014 ; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2706.
Texte intégralThirlway, Jenny, Adam Lodge, Andria Pelava, Daniel J. Williamson, Davide Carta, Majid Al Nakeeb, Justyna Mysliwy, Paul J. M. Jackson, David E. Thurston et Robert J. Lutz. « Abstract C023 : IKS01, a next generation antibody drug conjugate, shows target-dependent efficacy in a platinum-resistant tumor model with low levels of folate receptor α expression ». Dans Abstracts : AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics ; October 26-30, 2019 ; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-c023.
Texte intégralMatherly, Larry H., Xin Zhang, Adrianne Wallace, Zhanjun Hou, Christina George, Xilin Zhou et Aleem Gangjee. « Abstract 4481 : Tumor-targeting with novel 6-substituted thienoyl[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α, and inhibition of de novopurine nucleotide biosynthesis ». Dans Proceedings : AACR 106th Annual Meeting 2015 ; April 18-22, 2015 ; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4481.
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