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1

Roebuck, Derek. « Focal liver lesion in children ». Pediatric Radiology 38, S3 (10 mai 2008) : 518–22. http://dx.doi.org/10.1007/s00247-008-0850-9.

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Goral, Vedat, Kerem Mert Goral et Necati Ormeci. « Follow-up Strategies in Focal Liver Lesions and Treatment Methods ». Gastroenterology Pancreatology and Hepatobilary Disorders 6, no 2 (12 janvier 2022) : 01–07. http://dx.doi.org/10.31579/2641-5194/059.

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Today, advances in cross-sectional imaging have led to the detection and early recognition of incidental/focal liver lesions (FCL). In approximately 17,000 cases of chest CT, incidental liver lesions were found in 6% [1]. In general, FCL consists of hepatocytes, biliary epithelium, mesenchymal tissue, connective tissue, or metastasized cells from distant sites. Most incidental lesions are benign, some may require careful management and treatment. In evaluating the lesion, the patient's clinical history, underlying disease and age factor should be considered. FCL can be detected at a rate of 10-30% in normal healthy and chronic liver disease patients, and even in oncology patients with malignancy, FCLs can be highly benign (50-80%)
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Liao, Ai-Ho, Ya-Chien Cheng, Chien-Hsiu Weng, Ting-Fen Tsai, Wei-Hsiang Lin, Shiou-Hwei Yeh, Wen-Chun Yeh et Pai-Chi Li. « Characterization of Malignant Focal Liver Lesions with Contrast-Enhanced 40 MHz Ultrasound Imaging in Hepatitis B Virus X Transgenic Mice : A Feasibility Study ». Ultrasonic Imaging 30, no 4 (octobre 2008) : 203–16. http://dx.doi.org/10.1177/016173460803000402.

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Contrast-enhanced ultrasound (CEUS) imaging has been a reliable clinical method of detecting three vascular contrast phases and characterizing focal liver lesions. Previous results were all from human (i.e., clinical studies). The main purpose of this study was to extend this to small animals and to investigate the feasibility of using CEUS in preclinical research. Specifically, high-frequency (40 MHz) ultrasound liver imaging with albumin-shelled microbubbles was employed to detect the three vascular contrast phases and characterize focal liver lesions that developed in thirteen Hepatitis B virus X (HBx) transgenic mice at around 14 to 16 months of age. Previous studies indicated that 90–100% incidence of hepatocellular carcinoma (HCC) was observed in HBx transgenic male mice. After injecting the contrast agent, the time-intensity curves (TICs) of focal liver lesions, vessels in focal liver lesions and surrounding liver parenchyma tissues were measured for 30 minutes. The peak of mean intensity relative to the baseline increased 7.36 dB (p<0.02). On the other hand, the mean contrast between the focal liver lesion and the liver parenchyma increased by 7.74 (p<0.05) dB, thus allowing clear detection of the lesion margin. Histopathology investigations confirmed the development of the lesion in these mice. In addition, guidelines of European Federation of Societies for Ultrasound in Medicine and Biology were followed as an attempt to characterize features of the TICs in mice. The arterial phase was defined as 2 to 60 seconds post contrast injection, and the parenchyma phase was defined as the time period from 10 to 30 minutes post contrast injection. Comparing the imaging with the pathology results, the sensitivity, specificity and accuracy of CEUS for the detection of malignant focal liver lesion in HBx transgenic mice were 91%, 100% and 92%. These results demonstrated that high-frequency CEUS imaging potentially can be used for detecting the three vascular contrast phases of malignant focal liver lesions and characterizing malignant focal liver lesions in mice. Thus can be a valuable tool in preclinical research.
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Shiozawa, Kazue, Manabu Watanabe, Takashi Ikehara, Michio Kogame, Mie Shinohara, Masao Shinohara, Koji Ishii, Yoshinori Igarashi, Hiroyuki Makino et Yasukiyo Sumino. « Evaluation of Hemodynamics in Focal Steatosis and Focal Spared Lesion of the Liver Using Contrast-Enhanced Ultrasonography with Sonazoid ». Radiology Research and Practice 2014 (2014) : 1–7. http://dx.doi.org/10.1155/2014/604594.

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We aim to investigate the hemodynamics in focal steatosis and focal spared lesion of the liver using contrast-enhanced ultrasonography (CEUS) with Sonazoid. The subjects were 47 patients with focal steatosis and focal spared lesion. We evaluated enhancement patterns (hyperenhancement, isoenhancement, and hypoenhancement) in the vascular phase and the presence or absence of a hypoechoic area in the postvascular phase for these lesions using CEUS. Of the 24 patients with focal steatosis, the enhancement pattern was isoenhancement in 19 and hypoenhancement in 5. Hypoechoic areas were noted in the postvascular phase in 3 patients. Of the 23 patients with focal spared lesions, the enhancement pattern was isoenhancement in 18 and hyperenhancement in 5. No hypoechoic areas were noted in the postvascular phase in any patient. The hemodynamics in focal steatosis and focal spared lesions in nondiffuse fatty liver can be observed using low-invasive procedures in real-time by CEUS. It was suggested that differences in the dynamics of enhancement in the vascular phase of CEUS were influenced by the fat deposits in the target lesion, the surrounding liver parenchyma, and the third inflow.
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Piorkowska, Marta Anna, Rok Dezman, Maria E. Sellars, Annamaria Deganello et Paul S. Sidhu. « Characterization of a hepatic haemangioma with contrast-enhanced ultrasound in an infant ». Ultrasound 26, no 3 (19 octobre 2017) : 178–81. http://dx.doi.org/10.1177/1742271x17733298.

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Focal liver lesions are uncommon in the paediatric population, majority are benign but need to be clearly identified as benign. Contrast-enhanced ultrasound has recently received approval for paediatric hepatic use and represents an inexpensive and safe alternative to computed tomography and magnetic resonance imaging for focal liver lesion characterization. We report a case of an incidental focal liver lesion in a four-month-old infant, indeterminate on B-mode ultrasound but successfully characterized with contrast-enhanced ultrasound as a haemangioma, without recourse to other imaging techniques, and with minimal patient discomfort.
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Chi, Yanling, Jiayin Zhou, Sudhakar K. Venkatesh, Su Huang, Qi Tian, Tiffany Hennedige et Jimin Liu. « Computer-aided focal liver lesion detection ». International Journal of Computer Assisted Radiology and Surgery 8, no 4 (31 mars 2013) : 511–25. http://dx.doi.org/10.1007/s11548-013-0832-8.

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Roderburg, Christoph, Sven H. Loosen, Philipp Bruners et Tom Luedde. « Die unklare Leberraumforderung ». DMW - Deutsche Medizinische Wochenschrift 144, no 23 (novembre 2019) : 1651–64. http://dx.doi.org/10.1055/a-0733-6122.

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AbstractUnknown liver lesions represent a common clinical challenge, for example in the context of routine ultrasound examinations of primary care physicians. There are different data on the prevalence of primary liver lesions in the literature. As such, a forensic autopsy series described focal liver lesions in about 50 % of all examined men between 35 and 69 years of age with an increasing incidence for older people. In the diagnostic work-up of unclear liver lesions, a careful distinction between lesions that occur in asymptomatic and healthy individuals and are benign in over 95 % of cases, and lesion found in patients with pre-existing malignant, inflammatory or cirrhotic disease must be made. The main goal in the diagnosis of unclear liver lesions is to prove the benignity of the lesion and to exclude a malignant cause as reliably as possible. In case of benign lesions, an attempt should be made to achieve an exact classification. The most common benign focal liver lesions include liver cysts, focal fatty liver deposition or sparing, haemangiomas, focal calcifications, focal nodular hyperplasia (FNH), nodular regenerative hyperplasia, biliary hamartomas (von-Meyenburg complexes) and hepatocellular adenomas. Abscesses, inflammatory infiltrations or pseudotumors as well as sites of extramedullary haematopoiesis are observed much less frequently. Among the most frequent malignant focal liver lesions are metastases of other tumor entities such as colorectal cancer or pancreatic adenocarcinoma as well as hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCA). Other entities such as hepatic lymphomas or mesenchymal malignant neoplasia are extremely rare.
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Sansone, Vito, Lorenzo Falsetti, Francesco Tovoli, Rita Golfieri, Matteo Cescon et Fabio Piscaglia. « An Uncommon Focal Liver Lesion : Intrahepatic Splenosis ». Journal of Gastrointestinal and Liver Diseases 29, no 2 (3 juin 2020) : 257–62. http://dx.doi.org/10.15403/jgld-617.

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Multiple focal liver lesions were incidentally detected in a patient screened by ultrasound for a recent diagnosis of lower limb deep vein thrombosis, for which anticoagulation had been initiated. Past medical history reported a post-traumatic splenectomy 15 years before. Magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) showed a subcapsular lesion in liver segment 5 consistent with focal nodular hyperplasia (FNH) and multiple other nodules, with a different pattern from the former, judged as probable hepatic adenomas by MRI but probable hemangiomas by CEUS (hyperenhancement in the late phase). Therefore, another MRI with gadoxetic acid was performed. The diagnosis of FNH was confirmed. The other lesions showed an hyperenhancing pattern in the arterial phase with progressive wash-out in the portal and late phase and marked hypointensity in the hepatobiliary phase. This pattern apparently confirmed the hypothesis of adenomas, with a potential risk of malignancy due to the hepatobiliary phase pattern and the recent occurrence of deep vein thrombosis. Due to the inherent risk of spontaneous bleeding from subcapsular adenomas increased by the ongoing anticoagulant therapy and the recommendation of international guidelines to resect adenomas in male subjects, the patient was directly offered surgery. Pathology of the resected specimens confirmed one FNH but demonstrated intrahepatic splenosis for all other lesions. This case suggests that in the setting of previous splenic trauma any discrepancy between MRI and CEUS findings should lead one to consider also the hypothesis of intrahepatic splenosis.
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Shahid, Soban, Sahar Javed et Mustafa Ali Siddiqi. « Analysis of the Role of Shear Wave Elastography in Diagnosing Focal Liver Lesions ». Pakistan Journal of Medical and Health Sciences 16, no 8 (31 août 2022) : 361–63. http://dx.doi.org/10.53350/pjmhs22168361.

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Objective: Focal hepatic lesions are the second leading cause of death in men worldwide. However, shear wave elastography (SWE) has proved to help assess liver fibrosis. We aim to demonstrate the role of shear wave elastography in the diagnosis of focal liver lesions. Methods: A prospective study was conducted in the radiology department of CPEIC Multan from April 2021-April 2022. A total of 70 patients with 93 focal lesions were included. Shear wave elastography (SWE) was performed on all the patients, and local lesions and parenchyma stiffness values were calculated. Ten patients were excluded as they failed elastography acquisitions. Contrast-enhanced CT and MRI were performed on the remaining 60 patients. Thirty-two patients underwent liver biopsy. Benign focal lesions were confirmed by analyzing the results of ultrasound biopsy, CT, and MRI. Results: Cholangiocarcinoma was found to have the highest stiffness value (34.2kPa), hence the stiffest malignant lesion. Focal nodular hyperplasia had a stiffness value of 25.4kPa and was the most stiff benign lesion. The average stiffness value between malignant and benign lesions had a significant difference, the value of malignant lesions being significantly high ( p<0.001). Conclusion: Shear wave elastography can efficiently differentiate between malignant and benign hepatic lesions and can individually characterize these lesions accurately. Keywords: Focal liver lesions, malignant, stiffness value, shear wave elastography, benign
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Colagrande, Stefano, Francesco Regini, Filippo Pasquinelli, Lorenzo Nicola Mazzoni, Francesco Mungai, Antonella Filippone et Luigi Grazioli. « Focal Liver Lesion Classification and Characterization in Noncirrhotic Liver ». Journal of Computer Assisted Tomography 37, no 4 (2013) : 560–67. http://dx.doi.org/10.1097/rct.10.1097/rct.0b013e3182951fe9.

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Taori, Kishor, Rupan Sanyal, Rajesh Jawale, Jawahar Rathod et Manish Bhagat. « Intrabiliary Hydatid Without Any Focal Liver Lesion ». Journal of Ultrasound in Medicine 25, no 3 (mars 2006) : 397–98. http://dx.doi.org/10.7863/jum.2006.25.3.397.

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Rembak-Szynkiewicz, Justyna, Barbara Bobek-Billewicz, Maria Sokół et Marek K. Jurkowski. « Current methods of focal liver lesion diagnosis ». Polish Annals of Medicine 20, no 2 (décembre 2013) : 141–48. http://dx.doi.org/10.1016/j.poamed.2013.09.003.

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Costa, R., P. Santos, F. Alves, R. Abreu et A. Faria. « A rare case of focal liver lesion ». European Journal of Internal Medicine 24 (octobre 2013) : e145. http://dx.doi.org/10.1016/j.ejim.2013.08.374.

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Park, Hee Sun, Young Jun Kim, Mi Hye Yu, Sung Il Jung et Hae Jeong Jeon. « Shear Wave Elastography of Focal Liver Lesion ». Ultrasound Quarterly 31, no 4 (décembre 2015) : 262–71. http://dx.doi.org/10.1097/ruq.0000000000000175.

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Numminen, K., H. Isoniemi, J. Halavaara, P. Tervahartiala, H. Mäkisalo, L. Laasonen et K. Höckerstedt. « Preoperative assessment of focal liver lesions : multidetector computed tomography challenges magnetic resonance imaging ». Acta Radiologica 46, no 1 (février 2005) : 9–15. http://dx.doi.org/10.1080/02841850510016108.

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Purpose: To investigate prospectively multidetector computed tomography (CT) (MDCT) and magnetic resonance (MR) imaging (MRI) in the preoperative assessment of focal liver lesions. Material and Methods: Multiphasic MDCT and conventional gadolinium‐enhanced MRI were performed on 31 consecutive patients prior to hepatic surgery. All images were blindly analyzed as consensus reading. Lesion counts and their relation to vascular structures and possible extrahepatic disease were determined. The data from the MDCT and MRI were compared with the results obtained by intraoperative ultrasound (IOUS) and palpation. Histopathologic verification was available. Results: At surgery, IOUS and palpation revealed 45 solid liver lesions. From these, preoperative MDCT detected 43 (96%) and MRI 35 (78%) deposits. MDCT performed statistically better than MRI in lesion detection ( P = 0.008). Assessment of lesion vascular proximity was correctly determined by MDCT in 98% of patients and by MRI in 87%. Statistical difference was found ( P = 0.002). IOUS and palpation changed the preoperative surgical plan as a result of extrahepatic disease in 8/31 (26%) cases. In MDCT as well in MRI extrahepatic involvement was suspected in two cases. Conclusion: MDCT was superior to MRI and nearly equal to IOUS in liver lesion detection and in the determination of lesion vascular proximity. However, both techniques fail to reliably detect extrahepatic disease.
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Agha, Adnan, Manuele Furnari, Rafaat Morched Chakik, Mamdouh M. Abdulhadi Ali, Dib Alsaudi, Mohammed Bazeed, Vincenzo Savarino et Edoardo G. Giannini. « Hepatocellular Carcinoma Is the Most Frequent Final Diagnosis of Focal Liver Lesions Identified in a Cross-Sectional Evaluation of Patients with Chronic Liver Disease in Saudi Arabia ». Journal of Cancer Research 2015 (6 janvier 2015) : 1–4. http://dx.doi.org/10.1155/2015/492782.

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Background. Hepatocellular carcinoma (HCC) is a frequent diagnosis in patients with chronic liver disease (CLD) and a newly identified liver lesion, although benign diseases may also be responsible for this finding. Objective. To evaluate the characteristics of focal liver lesions in a population of patients with CLD not under surveillance for HCC in the Middle East. Methods. We performed a cross-sectional study evaluating 77 patients with CLD and a focal liver lesion identified during ultrasonography. Patients’ characteristics were analyzed on the basis of the final diagnosis (HCC versus benign lesions). Results. The most frequent diagnosis was HCC (64.9%). These patients were older (median age 64 versus 55 years, P=0.003) and cirrhotics (80.0% versus 51.9%, P=0.018), with multinodular lesions (58.0% versus 29.6%, P=0.031) and portal vein thrombosis (24.0% versus 0%, P=0.001) compared to patients with benign lesions. Prevalence of elevated alpha-fetoprotein (>10 ng/mL) was similar in both groups (80.0% versus 88.9%, P=0.198). Cirrhosis (odds ratio: 3.283) and multinodularity (odds ratio: 2.898) were independently associated with HCC. Conclusions. HCC is the most common diagnosis in Middle-Eastern patients with CLD and a liver lesion identified outside HCC surveillance programs, especially in cirrhotic patients. In these patients, elevated alpha-fetoprotein does not differentiate HCC from benign lesions.
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Savushkina, N. Y., et T. A. Fatykhova. « A case of misdiagnosis of liver cancer with metastases in a patient with systemic vasculitis ». Kazan medical journal 80, no 1 (15 janvier 1999) : 72. http://dx.doi.org/10.17816/kazmj65185.

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In the group of malignant liver lesions, the frequency of occurrence of metastatic lesions is in the first place. It is distinguished by a pronounced variety of the echographic picture. However, not always a vivid picture of focal lesion corresponds to a true metastatic lesion. The presented observation can serve as an example of such a situation.
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Forgione, Antonella, Francesco Tovoli, Matteo Ravaioli, Matteo Renzulli, Francesco Vasuri, Fabio Piscaglia et Alessandro Granito. « Contrast-Enhanced Ultrasound LI-RADS LR-5 in Hepatic Tuberculosis : Case Report and Literature Review of Imaging Features ». Gastroenterology Insights 12, no 1 (17 janvier 2021) : 1–9. http://dx.doi.org/10.3390/gastroent12010001.

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Background: The liver is involved in disseminated tuberculosis in more than 80% of cases while primary liver involvement is rare, representing <1% of all cases. Hepatic tuberculosis (TB) can be treated by conventional anti-TB therapy; however, diagnosing this disease remains a challenge. The diagnosis might be particularly difficult in patients with a single liver lesion that could be misdiagnosed as a tumor or other focal liver lesions. Although computed tomography (CT) and magnetic resonance imaging (MRI) findings have been described, there is a paucity of literature on contrast-enhanced ultrasound (CEUS) features of hepatic TB. Case Summary: herein, we describe a case of a patient with tuberculous lymphadenopathy and chronic Hepatitis C Virus (HCV)-related liver disease who developed a single macronodular hepatic TB lesion. Due to the finding of a hepatocellular carcinoma (HCC) highly suggestive CEUS pattern, specifically a LR5 category according to the Liver Imaging Reporting and Data System (LI-RADS), and a good response to antitubercular therapy, a non-invasive diagnosis of HCC was made, and the patient underwent liver resection. We also review the published literature on imaging features of hepatic TB and discuss the diagnostic challenge represented by hepatic TB when occurs as a single focal liver lesion. Conclusions: this report shows for the first time that the CEUS pattern of hepatic TB might be misinterpreted as HCC and specific imaging features are lacking. Personal history and epidemiological data are mandatory in interpreting CEUS findings of a focal liver lesion even when the imaging pattern is highly suggestive of HCC.
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Del Prato, Alberto, Michela Perinetti, Gerardo Dessì, Fabio Chiesa, Ilan Rosenberg, Teseo Stefanini, Franco Fedeli, Giovanni Berisso, Alberto Tagliafico et Alessandro Villa. « A rare diagnosis of a focal liver lesion ». Italian Journal of Medicine 9, no 1 (20 mars 2015) : 71. http://dx.doi.org/10.4081/itjm.2015.506.

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Tharayil, Vivek, et Lewis R. Roberts. « Evaluation of a Focal Lesion in the Liver ». Gastroenterology 139, no 2 (août 2010) : e10-e11. http://dx.doi.org/10.1053/j.gastro.2009.09.072.

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Chaudhari, Dhara, Atul Khanna, Puneet Goenka et Mark Young. « Radiographic Difference in Focal Liver Lesion of Cholangiocarcinoma ». American Journal of Gastroenterology 108 (octobre 2013) : S341. http://dx.doi.org/10.14309/00000434-201310001-01154.

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Röther, Mareike, Jean-Francois Dufour et Beat Schnüriger. « An Uncommon Cause of a Focal Liver Lesion ». Gastroenterology 144, no 3 (mars 2013) : 510–659. http://dx.doi.org/10.1053/j.gastro.2012.10.017.

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Sood, Ajit, Rahul Gupta et Aminder Singh. « A Rare Cause of a Focal Liver Lesion ». Gastroenterology 147, no 1 (juillet 2014) : e14-e15. http://dx.doi.org/10.1053/j.gastro.2014.02.045.

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Verhagen, MV, O. Ciocarlie, P. Humphries et T. Watson. « Contrast-enhanced ultrasound for multiple liver lesions after bone marrow transplant in a child with leukaemia : Multifocal focal nodular hyperplasia ». Ultrasound 27, no 2 (13 août 2018) : 122–26. http://dx.doi.org/10.1177/1742271x18795328.

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We present a case of a two-year-old girl in which liver lesions were characterised on contrast-enhanced ultrasound as multifocal focal nodular hyperplasia. This child had previously undergone haematopoietic stem cell transplantation for juvenile myelomonocytic leukaemia and was suspected to have hepatobiliary graft versus host disease. Liver biopsy was performed to confirm the unexpected focal nodular hyperplasia and look for concurrent graft versus host disease. Focal nodular hyperplasia was histologically confirmed on a background of diffuse liver damage in keeping with polypharmacotherapy, steatosis and sepsis. An element of graft versus host disease was not excluded but was not confidently shown in the sample of the lesion. This case report describes and illustrates how contrast-enhanced ultrasound may be of use to further assess hepatic lesions in a complex case of multifactorial hepatic pathology. Radiologists, haematologists and pathologists should be aware that multifocal focal nodular hyperplasia is part of the differential diagnosis of liver lesions in a child with liver damage due to complex disease and treatment. Biopsy remains the gold standard, if there is a concurrent clinical suspicion of graft versus host disease.
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Breder, V. V., R. B. Alikhanov, S. S. Bagnenko, E. N. Bessonova, V. A. Isakov, N. E. Kudashkin, B. M. Medvedeva, A. V. Mishchenko, M. S. Novruzbekov et V. S. Rudakov. « Screening and Early Diagnosis of Hepatocellular Cancer and Optimization of Diagnostic Imaging Techniques : A Review and Conclusion of the Expert Panel ». Russian Journal of Gastroenterology, Hepatology, Coloproctology 32, no 5 (28 février 2023) : 16–23. http://dx.doi.org/10.22416/1382-4376-2022-32-5-16-23.

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Аim: to describe modern approaches for screening and early diagnosis of hepatocellular carcinoma (HCC).Key points. Screening for HCC in high-risk groups (cirrhosis of any etiology, patients with chronic viral hepatitis B and patients with F3 liver fibrosis) should be organized as regular (every 6 months) liver ultrasound in combination with determination of the serum alpha-fetoprotein (AFP) level. At an AFP level of ≥ 20 ng/ml, even in the absence of changes according to ultrasound data, it is advisable to perform MRI with a hepatospecific contrast agent (gadoxetic acid) which makes it possible to detect very small focal liver lesions. If focal liver lesions of 1–2 cm are detected on ultrasound, additional imaging of the liver using MRI with a hepatospecific contrast agent gadoxetic acid helps to identify HCC at an earlier stage or high degree dysplastic nodes. When planning surgical treatment and liver transplantation, it is preferable to use MRI with a hepatospecific contrast agent, since the presence of the hepatobiliary phase may allow the detection of additional smaller focal liver lesions and assess the nature of the focal liver lesion. When a patient is included in the waiting list for liver transplantation, the optimal frequency of liver MRI is 1 time in 3 months.Conclusion. MRI with hepatospecific contrast agent gadoxetic acid is effective in screening, early diagnosis and treatment planning for HCC.
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Stollmayer, Róbert, Bettina Katalin Budai, Aladár Rónaszéki, Zita Zsombor, Ildikó Kalina, Erika Hartmann, Gábor Tóth et al. « Focal Liver Lesion MRI Feature Identification Using Efficientnet and MONAI : A Feasibility Study ». Cells 11, no 9 (5 mai 2022) : 1558. http://dx.doi.org/10.3390/cells11091558.

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Liver tumors constitute a major part of the global disease burden, often making regular imaging follow-up necessary. Recently, deep learning (DL) has increasingly been applied in this research area. How these methods could facilitate report writing is still a question, which our study aims to address by assessing multiple DL methods using the Medical Open Network for Artificial Intelligence (MONAI) framework, which may provide clinicians with preliminary information about a given liver lesion. For this purpose, we collected 2274 three-dimensional images of lesions, which we cropped from gadoxetate disodium enhanced T1w, native T1w, and T2w magnetic resonance imaging (MRI) scans. After we performed training and validation using 202 and 65 lesions, we selected the best performing model to predict features of lesions from our in-house test dataset containing 112 lesions. The model (EfficientNetB0) predicted 10 features in the test set with an average area under the receiver operating characteristic curve (standard deviation), sensitivity, specificity, negative predictive value, positive predictive value of 0.84 (0.1), 0.78 (0.14), 0.86 (0.08), 0.89 (0.08) and 0.71 (0.17), respectively. These results suggest that AI methods may assist less experienced residents or radiologists in liver MRI reporting of focal liver lesions.
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Wasif, Nabil, Sebastian Sasu, William C. Conway et Anton Bilchik. « Focal Nodular Hyperplasia : Report of an Unusual Case and Review of the Literature ». American Surgeon 74, no 11 (novembre 2008) : 1100–1103. http://dx.doi.org/10.1177/000313480807401112.

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Focal nodular hyperplasia (FNH) is the second most common benign lesion of the liver and a common differential in the workup of solid liver lesions. With increasing use of modern imaging modalities FNH is becoming clinically more relevant. We present a case of pedunculated FNH presenting as a pericholecystic mass. This was resected laparoscopically due to persistent symptoms and uncertainty in diagnosis. We summarize the current literature with regard to the diagnosis, etiology, and management of FNH lesions.
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Wu, Size, Rong Tu, Guangqing Liu, Ruixia Nan, Ying Guan, Enhai Zheng et Yanyan Zhao. « Anatomical variation of the liver with elongated left lobe may be a trap forthe ultrasound detection of focal liver lesion. » Medical Ultrasonography 17, no 1 (1 mars 2015) : 12. http://dx.doi.org/10.11152/mu.2013.2066.171.zwu.

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Aims: The aim of this study was to evaluate the impact of anatomical variations of the elongated left lobe of the liver on the ultrasound detection of focal liver lesions. Materials and methods: We evaluated, by ultrasonography (US), 296 patients with elongated left lobe of the liver and 30 patients with focal lesions in the normal length left lobe of the liver. Those patients had undergone prior computed tomography (CT) evaluation. Results: Of the 296 patients evaluated, 34 patients had focal lesions (the size range 11- 20 mm) in the distal region of the elongated left lobe of the liver, and none of the lesions was visualized at US examination (p<0.001). All the focal lesions in the normal length left lobe of the liver of the 30 patients were visualized by US without significant difference between the dimensions established by CT and US (p=0.136). Conclusion: Focal lesions in the distal region of elongated left lobe of the liver are difficult to be detected by conventional US examination and the main reason is the impact of anatomical localization on the examination protocol.
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Sannikov, M. Yu, O. Yu Borodin, A. A. Ermakova et A. A. Kolotushkina. « Contrast-Enhanced Magnetic Resonance Imaging with Magnetic Transfer Effect in Differential Diagnosis of Hemangiomas and Metastases of Liver ». Medical Visualization, no 1 (28 février 2017) : 20–28. http://dx.doi.org/10.24835/1607-0763-2017-1-20-28.

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Objective: to investigate the operating characteristics of contrast MRI of the liver using magnetization transfer effect in the differential diagnosis of hemangiomas and metastatic lesions in comparison with dynamic contrast.Material and methods. The material of the study were dynamic contrast MRI images of 25 patients with diagnosis of direction of focal liver lesion. Inclusion criteria were detection of typical MR-semiotic for hemangioma (n = 10 to 40% of cases) or multiple liver metastases (n = 15 to 60% of cases).In the group with metastases exclusion criteria was the primary detection of obscure single focal lesions, as well as the diagnosis of other primary tumors, in particular cholangiocellular cancer (n = 1). All MRI studies were performed using MRI Toshiba Titan Octave with of 1.5 Tesla magnetic field. T1-weighted static contrast MRI investigation of liver performed after 3–5 minutes after a series of dynamic contrast MRI with modes: T1-FE-FSat and T1-TSEMTS (Δf = -210 Hz, FA = 600°). The magnevist at a dose of 0.1 mmol/kg was used as a contrast agent. Each focal liver lesion differentiated between hemangiomaand metastasis with the calculation of contrast ratio (CR) for each lesion. Statistical analysis of CR was performed using T-test and T-test Welch. The sensitivity and specificity parameters were compared during the ROC-analysis.Results. In our statistical analysis groups formed not from patients, because we were compared results about focal lesions of a liver referred to metastasis or hemangiomas. All the patients included in a research had focal lesions mostly multiple and in the comparative analysis of contrast ratio in the T1-FE-FSat and T1-TSE-MTC was carried out on 21 (20%) hemangiomas and 84 (80%) metastasises. The significant (p < 10–4) contrast enhancement using T1-TSE-MTS, as in the case of hemangiomas and in metastatic lesions relative to T1-FE-FSat revealed by comparing the CRs. No significant differences were found in the differentiation of hemangiomas and liver metastases in modes T1-FE-FSat and T1-TSE-MTS when paired comparison of ROC-curves (p > 0.18). No significant differences were found when paired comparison of CRs between hemangiomas in T1-FE-FSat mode and metastases in T1-TSEMTSimages (p > 0.8). An additive effect (sensitivity and specificity – 98.8% and 85.7%) occurs when we used to CRcomm=35.7% in T1-FE-FSat modes and T1-TSE-MTS.Conclusions. 1. Contrast MRI using magnetization transfer effect allows significantly increase the contrast of focal liver formations on the type of hemangiomas and metastases. 2. The achieved contrast level in 2D TSE images with magnetization transfer effect of liver metastatic foci corresponds to that of hemangiomas in 2D FE mode. 3. Maximum parameters of sensitivity and specificity in the differential diagnosis of hemangiomas and liver metastases obtained by using 2D-FE-FSat and 2D-TSE-MTC in post contrast phase.
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Salama, Fady, Nimish Thakral, Venkata Rajesh Konjeti, Adrian Dawkins, Roberto Gedaly et Aman Khurana. « Sa1418 : DIAGNOSTIC CONTRAST ENHANCED ULTRASOUND IN FOCAL LIVER LESION ». Gastroenterology 162, no 7 (mai 2022) : S—1165. http://dx.doi.org/10.1016/s0016-5085(22)63477-2.

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Kirichenko, Igor Borisovich. « A clinical case of focal liver lesion in tuberculosis ». Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no 6 (1 juin 2021) : 67–70. http://dx.doi.org/10.33920/med-10-2106-08.

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In the clinical practice of a general practitioner, there are many difficulties in the diagnosis of certain nosological forms, even in spite of various diagnostic studies. This is often due to the fact that in most cases, the used methods, especially ultrasound, as well as the results of many biochemical studies, make it possible to suspect pathology or reveal its indirect signs. Accurate diagnostic methods such as laparoscopy, biopsy, targeted biopsy, computed tomography and colonoscopy are rarely used. The clinical case presented below is one of the confirmations of the above [2; 3].
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Ros, Pablo R., et Gary L. Davis. « The incidental focal liver lesion : Photon, proton, or needle ? » Hepatology 27, no 5 (mai 1998) : 1183–90. http://dx.doi.org/10.1002/hep.510270501.

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Demarco, Mario P., Perry Shen, Robert F. Bradley et Edward A. Levine. « Intraperitoneal Hemorrhage in a Patient with Hepatic Focal Nodular Hyperplasia ». American Surgeon 72, no 6 (juin 2006) : 555–59. http://dx.doi.org/10.1177/000313480607200620.

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Focal nodular hyperplasia (FNH) is a common benign liver tumor that is often confused with hepatic adenoma. Despite the benign course of both lesions, hepatic adenomas are associated with rupture and bleeding, and suggested management often includes prophylactic surgical resection. FNH lesions are thought to not rupture or bleed, and traditional management does not include resection. We report the case of a woman with FNH who presented with intraperitoneal hemorrhage after the rupture of a FNH lesion. Only six previous documented cases of hemoperitoneum associated with FNH have ever been reported. This report reviews all previously recorded cases of FNH lesions that have resulted in intraperitoneal hemorrhage. We suggest that although FNH is a benign lesion and intervention is typically unnecessary, the potential for rupture requiring surgical resection should always be considered.
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Chira, Romeo Ioan, Adriana Calauz, Simona Manole, Simona Valean et Petru Adrian Mircea. « Unusual discovery after an examination for abdominal pain : Abernethy 1b malformation and liver adenomatosis. A case report ». Journal of Gastrointestinal and Liver Diseases 26, no 1 (1 mars 2017) : 85–88. http://dx.doi.org/10.15403/jgld.2014.1121.261.abe.

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Congenital extrahepatic portosystemic shunt (Abernethy malformation) is a rare condition characterized by developmental abnormalities of the portal venous system resulting in the diversion of the portal blood from the liver to the systemic venous system through a complete or partial shunt of the portomesenteric blood. We report the case of an 18 year-old female examined for abdominal pain, presenting cholestasis syndrome and an elevated serum aspartate aminotransferase level. Liver ultrasound examination revealed the absence of the portal vein with a complete extrahepatic shunt of the portal blood, multiple focal liver lesions, and multiple associated vascular anomalies. A surgical portosystemic shunt and a secondary portosystemic shunt due to portal vein thrombosis were excluded, enabling the diagnosis of a congenital portosystemic shunt. A complex investigation also discovered bone anomalies, and the liver biopsy of the dominant focal lesion revealed adenoma. On a short-term follow-up under hepatoprotective medication, the biochemical parameters improved mildly; however, the size of the main focal lesion increased.Congenital absence of the portal vein often remains an incidental diagnosis. In experienced hands, ultrasonography can diagnose it, but a comprehensive thoraco-abdominal evaluation is compulsory, considering the many potential associated anomalies. In these patients, development of adenomatous liver lesions secondary to Abernethy type Ib malformation represents an indication for liver transplantation.Abbreviations: AMA: anti-mitochondrial antibodies; ASMA: anti-smooth muscle antibody; ANA: anti-nuclear antibody; anti-LKM-1: liver-kidney microsomal type 1 antibodies; CEPS: congenital extrahepatic portosystemic shunt; IVC: inferior vena cava; SMV: superior mesenteric vein; SV: splenic vein.
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ashraf, obaid, naseer choh et omair shah. « Qualitative And Quantitative Magnetic Resonance Imaging Assessment Of Focal Liver Lesions : A Study To Evaluate The Role Of Different MRI Sequences. » Journal of Research in Clinical Medicine 9, no 1 (7 juin 2021) : 27. http://dx.doi.org/10.34172/jrcm.2021.027.

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Background: Focal liver lesions have a broad differential diagnosis. MRI with its improved soft tissue characterization and newer sequences can significantly narrow the differentials especially when discriminating benign from malignant lesions. Methods: T1, T1 IN AND OUT OF PHASE, T2, LONG TE T2 AND Diffusion Weighted Imaging was done in 159 patients with USG documented focal liver lesion. Qualitative and quantitative assessment of ADC values and long TE images was done and a threshold for differentiating benign from malignant lesions was obtained. The MRI diagnosis was compared with final diagnosis obtained from histopathology in most cases or follow up and other tests (markers and RBC scan) were histopathology was not available. Sensitivity, specificity and accuracy of MRI sequences in differentiating various focal lesions were obtained. Results: T1 weighted images were useful for identifying fat, hemorrhage and iron within the lesions. T2 weighted imaging was able to correctly classify 82.0% lesions as malignant and 83.7% lesions as benign. Long TE T2 images were highly accurate in distinguishing haemangiomas and cysts from solid lesions. On diffusion-weighted (DW) imaging, 89.5% (i.e. 60 out of 67) lesions were correctly classified as malignant and 88.0% (i.e. 81 out of 92) lesions were correctly classified as benign. Threshold ADC value of 1.37 × 10-3 mm2/s is highly accurate for differentiating malignant from benign lesions. Conclusion: DWI is a sine qua non in liver lesion assessment allowing improved detection and characterization. Long TE T2 weighted imaging can accurately detect haemangiomas and cysts and rule out metastasis.
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Scali, Elena P., Triona Walshe, Hina Arif Tiwari, Alison C. Harris et Silvia D. Chang. « A Pictorial Review of Hepatobiliary Magnetic Resonance Imaging with Hepatocyte-Specific Contrast Agents : Uses, Findings, and Pitfalls of Gadoxetate Disodium and Gadobenate Dimeglumine ». Canadian Association of Radiologists Journal 68, no 3 (août 2017) : 293–307. http://dx.doi.org/10.1016/j.carj.2016.10.008.

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Magnetic resonance imaging (MRI) has a well-established role as a highly specific and accurate modality for characterizing benign and malignant focal liver lesions. In particular, contrast-enhanced MRI using hepatocyte-specific contrast agents (HSCAs) improves lesion detection and characterization compared to other imaging modalities and MRI techniques. In this pictorial review, the mechanism of action of gadolinium-based MRI contrast agents, with a focus on HSCAs, is described. The clinical indications, protocols, and emerging uses of the 2 commercially available combined contrast agents available in the United States, gadoxetate disodium and gadobenate dimeglumine, are discussed. The MRI features of these agents are compared with examples of focal hepatic masses, many of which have been obtained within the same patient therefore allowing direct lesion comparison. Finally, the pitfalls in the use of combined contrast agents in liver MRI are highlighted.
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Pang, Emily H. T., Alison C. Harris et Silvia D. Chang. « Approach to the Solitary Liver Lesion : Imaging and When to Biopsy ». Canadian Association of Radiologists Journal 67, no 2 (mai 2016) : 130–48. http://dx.doi.org/10.1016/j.carj.2015.07.005.

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The characterization and management of focal liver lesions is a commonly encountered problem in radiology. While the imaging findings will often be diagnostic, in equivocal cases the decision of how to proceed may be challenging. The primary modalities for liver lesion characterization are multiphase contrast-enhanced computed tomography and magnetic resonance imaging. Most lesions have typical imaging features, and when taken in conjunction with patient demographics and biochemistry the diagnosis can usually be made. Ancillary imaging modalities such as contrast-enhanced ultrasound and hepatobiliary specific contrast agents are also useful. Cirrhotic livers present a challenge due to the spectrum of benign, dysplastic, and malignant nodules that can occur. The report should include information necessary for accurate staging, and published standardized reporting guidelines should be taken into consideration. A decision to proceed to biopsy should be made only after multidisciplinary review of the case. If biopsy is required, fine needle aspiration is usually sufficient, though core needle biopsy may be required in certain circumstances.
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Stosic, Srdjan, Sanja Stojanovic, Stevan Idjuski et Jelena Stosic. « Hepatocellular carcinoma presenting with pyrexia and leukocytosis : A case report ». Medical review 70, no 1-2 (2017) : 48–52. http://dx.doi.org/10.2298/mpns1702048s.

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Introducion. This type of hepatocellular carcinoma is characterized by fever and persistent leukocytosis. Case report. This is a report of a patient with a long term fever accompanied by persistent leukocytosis. Abdominal ultrasonography revealed a focal lesion in the left hepatic lobe, whereas, computed tomography/magnetic resonance imaging findings were consistent with a liver abscess. The patient received therapy for liver abscess, without improvement. He underwent left lobe segmentectomy 3, with histological features of hepatocellular carcinoma (pseudoglandular type). Conclusion. In patients with focal hepatic lesions accompanied with raised temeparature and persistent leukocytosis, without adequate therapeutic response, this clinicopathological type of hepatocellular carcinoma should be considered.
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Colovic, Radoje, Nikica Grubor, Marjan Micev et Natasa Colovic. « Biliary mucinous cystadenoma of the liver with focal malignant alteration ». Srpski arhiv za celokupno lekarstvo 133, no 1-2 (2005) : 65–68. http://dx.doi.org/10.2298/sarh0502065c.

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Biliary mucinous cystadenoma of the liver is a rare tumor that develops almost exclusively in women. Its typical localization is near the hepatic hilus. It may become malignant, and therefore careful histological examination of the entire resected specimen is mandatory. Incomplete excision results in recurrence and occasionally in malignant alteration. The authors present a 66-year old woman who presented with the right upper abdominal pain and occasional vomiting, and who was diagnosed with cystic lesion of the right lobe of the liver. The lesion was totally excised by an open operation. It was filled with mucinous viscous fluid and there was proliferation in one part of the internal surface. The cystic lesion communicated with the common hepatic duct through a tiny duct (above the cystic duct), but in spite of that, it did not contain bile. Histological examination showed mucinous cystadenoma with focal malignant alteration. After the uneventful recovery, the pain and vomiting were eliminated and she has remained symptom free so far.
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Zhao, A. V., G. G. Karmazanovsky, S. A. Bugaev et A. O. Chugunov. « Diagnostic and treatment challenges in focal liver disease ». Almanac of Clinical Medicine 46, no 6 (29 novembre 2018) : 618–30. http://dx.doi.org/10.18786/2072-0505-2018-46-6-618-630.

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Finding a focal liver lesion during screening may not uncommonly lead to a misinterpretation of the results of radiological diagnostics. Based on the consolidation of our wide experience (more than 1000 cases) of surgical treatment of patients with various focal liver diseases, we analyzed the main causes of diagnostic pitfalls and, as a consequence, errors in the treatment of these patients. The most typical objective and subjective diagnostic pitfalls that may lead to a wrong treatment strategy are discussed with clinical cases taken as examples. The objective factors are related to the rarity of disease, absence of pathognomonic semiotics, as well as limitations in the resolution power of imaging methods. In addition, a misinterpretation of results of ultrasound examination, magnetic resonance imaging and multiaxial computed tomography may be explained by identical properties of images in different tumors related to similar physical and chemical properties of a lesion. The subjective factors are related to a wrong interpretation of clinical and instrumental assessment data, or insufficient evaluation needed in an individual patient. The number of diagnostic and treatment errors could be decreased by a multidisciplinary approach taking into account the opinions of various profile experts.
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Balagourouchetty, Lakshmipriya, Jayanthi K. Pragatheeswaran, Biju Pottakkat et G. Ramkumar. « GoogLeNet-Based Ensemble FCNet Classifier for Focal Liver Lesion Diagnosis ». IEEE Journal of Biomedical and Health Informatics 24, no 6 (juin 2020) : 1686–94. http://dx.doi.org/10.1109/jbhi.2019.2942774.

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Chen, Yufei, Cheng Zhang, Xianhui Liu et Gang Wang. « Focal Liver Lesion Classification Based on Receiver Operating Characteristic Analysis ». Journal of Medical Imaging and Health Informatics 9, no 2 (1 février 2019) : 284–92. http://dx.doi.org/10.1166/jmihi.2019.2609.

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Background: Computer-Aided Diagnosis (CAD) on Focal Liver Lesion (FLL) has been widely researched. It aims at classifying liver images into malignant or benign, so as to help doctors to make corresponding diagnosis. In most existing CAD systems, the automatic decision strategies on challenging cases usually lead to risky diagnosis. Objective: In this paper, we adopted a ROC optimal abstention model for FLL classification to reduce the misclassification risk. Method: The workflow of ROC based FLL classification includes the stages of feature extraction, statistic for building ROC curve and ROC optimal abstaining classification. Through investigating the properties of ROC, we can automatically find two optimal thresholds for building the abstention model. A part of cases refrains from being classified to achieve the lowest misclassification cost. Results: The model classifies the FLL medical records into positive (malignant), negative (benign) and abstaining cases. The abstained challenging cases can be carefully examined by experts in order to reduce the misclassification risk. Conclusion: Abundant experiments indicate that the proposed method can achieve satisfied results and is effective for FLL diagnosis.
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Sutherland, Tom, Emma Steele, Frans van Tonder et Kelvin Yap. « Solid focal liver lesion characterisation with apparent diffusion coefficient ratios ». Journal of Medical Imaging and Radiation Oncology 58, no 1 (1 juillet 2013) : 32–37. http://dx.doi.org/10.1111/1754-9485.12087.

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Mittal, Deepti, Vinod Kumar, Suresh Chandra Saxena, Niranjan Khandelwal et Naveen Kalra. « Neural network based focal liver lesion diagnosis using ultrasound images ». Computerized Medical Imaging and Graphics 35, no 4 (juin 2011) : 315–23. http://dx.doi.org/10.1016/j.compmedimag.2011.01.007.

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Purysko, A. S., E. M. Remer et J. C. Veniero. « Focal liver lesion detection and characterization with GD-EOB-DTPA ». Clinical Radiology 66, no 7 (juillet 2011) : 673–84. http://dx.doi.org/10.1016/j.crad.2011.01.014.

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&NA;. « Focal nodular hyperplasia of the liver is a clonal lesion ». Advances in Anatomic Pathology 4, no 3 (mai 1997) : 181. http://dx.doi.org/10.1097/00125480-199705000-00011.

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Quaia, Emilio, Elisa Mosconi, Francesca Degobbis et Roberto Pozzi Mucelli. « Focal liver lesion characterization using low acoustic power ultrasound imaging ». Academic Radiology 12, no 5 (mai 2005) : S66. http://dx.doi.org/10.1016/j.acra.2005.03.027.

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Abraham-Nordling, Mirna, Emma Öistämö, Thomas Josephson, Fredrik Hjern et Lennart Blomqvist. « The value of preoperative computed tomography combined with ultrasound in the investigation of small indeterminate liver lesions in patients with colorectal cancer ». Acta Radiologica 58, no 11 (12 mars 2017) : 1288–93. http://dx.doi.org/10.1177/0284185117693461.

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Background Computed tomography (CT) is used routinely for the preoperative detection of colorectal cancer (CRC) metastases. When small indeterminate focal liver lesions are detected that are too small to characterize (TSTC) on CT, additional imaging is usually needed, resulting in a potential delay in obtaining a complete diagnostic work-up. Purpose To determine the diagnostic accuracy of ultrasound (US) of the liver performed in direct conjunction to CT in the preoperative investigation among patients with newly diagnosed CRC when indeterminate liver lesions were found on CT. Material and Methods Preoperative investigations with CT and consecutive US where CT had shown at least one focal liver lesion in 74 patients diagnosed with CRC between June 2009 and February 2012 were retrospectively reviewed. Either histopathological findings or a combination of imaging and clinical follow-up one to three years after surgery was used as the reference. Results Liver metastases were diagnosed with CT/US in 13 out of 74 patients (17.6%). In one patient, a liver cyst was preoperatively regarded as liver metastasis by a combined CT/US. The sensitivity and specificity for the CT with consecutive US procedure was 100% (13/13) and 98.4% (60/61). Conclusion US performed in conjunction with CT in patients with indeterminate focal liver lesions on CT is an accurate work-up for detection of liver metastases in patients with newly diagnosed CRC. Although our results are promising, they cannot be considered safely generalizable to all hospitals.
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Alfayez, Adel, Helayel Almodhaiberi, Hussa Al Hussaini, Ibrahim Alhasan, Abdullah Algarni et Tharaa Takrouni. « Hepatic focal nodular hyperplasia in a five-year-old healthy boy : A case report and literature review ». International Journal of Hepatobiliary and Pancreatic Diseases 11, no 2 (27 août 2021) : 1–8. http://dx.doi.org/10.5348/100095z04aa2021cr.

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Introduction: Focal nodular hyperplasia is unusually seen in a pediatric age group, with few reported cases in the literature. We report the case of a 5-year-old boy not known to have medical illnesses, who was found to have a liver mass, underwent right trisectionectomy. The purpose of this report is to familiarize the healthcare community with similar events, review the literature, and discuss recommendations for future similar cases. Case Report: A case of focal nodular hyperplasia (FNH) in a 5-year-old healthy boy who was found to have a huge liver lesion on ultrasound imaging due to a vague abdominal pain and distension. The patient underwent surgical excision of the mass due to abdominal pain, distension, and atypical features of FNH in radiological examinations. Histopathological analysis revealed a focal nodular hyperplasia. Conclusion: Focal nodular hyperplasia considered a benign lesion that has no malignant transformation. The presenting symptoms are variable, usually asymptomatic. Laboratory tests have of little significance. Imaging modalities mainly ultrasound scan initially then magnetic resonance imaging (MRI) are useful to obtain more accurate characteristic features of the lesion. Uncertain diagnostic lesion needs to be biopsied and examined under microscopy. Confirming the diagnosis will follow an acceptable conservative management approach. Surgical resection is the preferred method in uncertain, questionable, or atypical features observed in radiological imaging.
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Nacheva-Georgieva, Emiliya Lyubomirova, Daniel Ilianov Doykov, Vladimir Nikolov Andonov, Katya Angelova Doykova et Silviya Bogdanova Tsvetkova. « Point Shear Wave Elastography and 2-Dimensional Shear Wave Elastography as a Non-Invasive Method in Differentiating Benign from Malignant Liver Lesions ». Gastroenterology Insights 13, no 3 (10 septembre 2022) : 296–304. http://dx.doi.org/10.3390/gastroent13030030.

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Non-invasive, ultrasound-based methods for visualizing and measuring tissue elasticity are becoming more and more common in routine daily practice. An accurate diagnosis of malignant and benign tumors is essential for determining the appropriate treatment. Despite the wide use of imaging techniques, the investigation for assessing the elasticity of focal liver lesions and their differentiating is still continuing. Aim: To investigate the value of point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) for the differential diagnosis of benign and malignant focal liver lesions. Materials and Methods: A total of 125 adult patients were included from the Clinic of Gastroenterology of University Hospital Kaspela, Plovdiv city, Bulgaria, in the period from January 2021 to July 2022. Participants were divided into two groups—with benign (hemangiomas) and malignant focal liver lesions (hepatocellular carcinoma). The group with benign lesions included 63 patients and the group with malignant focal liver lesions (FLLs)—62 patients. Point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) integrated in the same ultrasound machine (Esaote MyLab™ 9Exp) were performed for each lesion. Results: Malignant FLLs have significantly higher stiffness in both pSWE (2.52–4.32 m/s, 90% CI: 2.37 to 2.68, 90% CI: 4.19 to 4.55) and 2d-SWE (2.52–4.43 m/s, 90% CI: 2.31 to 2.65, 90% CI: 4.27 to 4.61). Conclusion: 2D-SWE and pSWE could provide complementary data about FLLs. They enable us to conveniently and easily obtain accurate stiffness information of FLLs.
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