Thèses sur le sujet « Farman »
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1
Farman-Farmaian, Ayshe. « Videodisc-based simulations for language learning ». Thesis, Massachusetts Institute of Technology, 1987. http://hdl.handle.net/1721.1/73286.
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Thesis (M.S.V.S.)--Massachusetts Institute of Technology, Dept. of Architecture, 1987.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.
Accompanied by videocassette (30 min. : sd., col. ; 3/4 in.) entitled: En quête d'un appartement.
Bibliography: leaves 38-39.
by Ayshe Farman-Farmaian.
M.S.V.S.
2
Ebrahimkhil, Jasmin Jaheda [Verfasser], Wolfgang [Akademischer Betreuer] Wuttke, Michael [Akademischer Betreuer] Müller et Patricia [Akademischer Betreuer] Virsik-köpp. « Effekte von Estradiol und Raloxifen sowie der pflanzlichen Substanzen Agnus castus, Belamcanda chinensis und Silybum marianum im Brustgewebe der ovarektomierten Ratte im Hinblick auf das Mammakarzinomrisiko / Jasmin Jaheda Ebrahimkhil, geb. Farman. Gutachter : Michael Müller ; Patricia Virsik-Köpp. Betreuer : Wolfgang Wuttke ». Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2013. http://d-nb.info/104424951X/34.
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Valderová, Lenka. « Ocenění společnosti FARMAK, a.s ». Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-199756.
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The diploma thesis is dealing with the valuation of the Compaq FARMAK, a.s. and it is created for potential investors. The company evaluation refers to December 4, 2013. The beginning of the thesis is related to the theoretical part, where methods used in the practical part are described. In the first instance, there is financial analysis of financial statements performed. The analysis has three elements -- vertical analysis, horizontal analysis and ratio analysis. Then the strategic analysis is performed with its analysis of micro and macro environment. Then financial plan was planned based on previous analyses and prognosis of value generators. The valuation of the company is using yield method of discounted free cash flow. -- FCFF and then the value is compared with the accounting value of the company.
4
Částková, Monika. « Farma v jeskyni : Odtržení ». Master's thesis, Akademie múzických umění v Praze.Hudební a taneční fakulta. Knihovna, 2018. http://www.nusl.cz/ntk/nusl-391690.
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The thesis studies and describes movement in physical theatre. Specifically it works with the production Odtržení of the dance group Farm in the cave.
The production was selected as the best production of the year 2016 on the festival of Czech Dance Platform. The thesis uncovers the backstage of preparations of the production, including the study stay in Japan and the process of creation of individual components of the production. It describes the content and the movement interpretation of individual scenes and situations. Since the author of the thesis took part in the production as one of its interpreters and at the same time participated in its choreography, the thesis includes subjective reflections, personal experience and interviews with other actors in the production.
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Trykarová, Štěpánka. « Farma větrných elektráren Mauricius ». Master's thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-9194.
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This diploma thesis evaluates the present standing of the wind energy in the Czech republic and in the world. It targets the results of new installed wind power stations to the economy. It ilustrates the preparation procedure. It shows the reasons why to invest to the wind energy. It is concerned with the question, if the building-up of wind power plant has the perspective of economic efficiency. It points out the effect on the environment and health.
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Kühnová, Edita. « Farma v Horní Lipové ». Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2016. http://www.nusl.cz/ntk/nusl-240235.
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This diploma thesis deals with the processing of project documentation in the documentation phase for construction of building object SO 01 – Detached house with facilities. The thesis is not worked out in full extent, as prescribed in Decree No. 62/2013 Coll. Amending Decree No. 499/2006 Coll., On Construction Documentation. It includes only part A (Data Accompanying Report), B (Summary Technical Report), C (Situational Drawings), D.1.1 (Architectural and Building Solutions) and D.1.3 (Fire Safety Solutions) of Appendix 6 of this Decree. In addition, a thermal-technical assessment of the building was elaborated. There are two specializations in small range as additional part of the documentation as well. The proposed two-storey house with small cellar is situated on flat land in the village of Lipová-lázně and layout of the object is divided into two parts, part of house with function of housing and part with facilities for cooking and catering for more persons.
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Holubová, Hana. « Včelí farma s prvky inovací ». Master's thesis, Vysoká škola ekonomická v Praze, 2015. http://www.nusl.cz/ntk/nusl-264048.
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The aim of the thesis is to create a business plan Bee farm U Králů in the region Šumava. The main activity of bee farm is the production of bee products. Thesis also deals with the problem of loss of beekeepers and the lack of awareness of this discipline in the Czech Republic through the beekeeping club, apitourism and bee educational trail. Bee farm is also pathfinder on the Czech market in the sphere apitherapy. The contribution of the thesis is in the support of beekeeping and in the production of quality products.
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Ketchum, Lynn G. « After 1,000 Years...Agave Farmin Is Back ». College of Agriculture, University of Arizona (Tucson, AZ), 1986. http://hdl.handle.net/10150/295372.
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Dominová, Barbora. « Rodinná farma jako přirozená součást venkovského prostoru ». Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-258237.
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The subject of this masters thesis Family farm as an organic part of the rural space is position of the rural space and agriculture with possibilities for solution of specific problems of the territory.
The goals of this thesis are divided into two partial tasks. The first of which is the literature review of contemporary position and happening on the countryside, the position of the family farms in the Czech Republic, the possibilities and conditions of goat breeding and requirements in cultivation. The second part is focused on project design of small family business with focus on dairy goats breeding in the LFA area and production of selected crops.
The results of this thesis describe the position of the rural and agriculture in the Czech Republic. The proposal of the family farm as a small business on the countryside represents the development possibility of the village, the attractiveness of the place and total avoidance of depopulation of the village.
10
Pönisch, Jens. « Farben in LaTeX ». Universitätsbibliothek Chemnitz, 2002. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-200200082.
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Dettleff, James A. « El faraón Betito ». La Mirada de Telemo, 2013. http://repositorio.pucp.edu.pe/index//handle/123456789/20420.
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Luego de un lustro de prolífica producción de miniseries biográficas de cantantes populares (desde “La lucha por un sueño” en el 2005), nuestra televisión parecía haber detenido su interés por este tipo de historias, retornando más bien a la realización de formatos de ficción de más largo aliento, colocando en nuestras pantallas telenovelas nacionales que luchaban por el rating con bastante éxito. Pero pareciera que el 2012 América Televisión decidió retomar las mini series biográficas de cantantes populares, y para ello recurrió a su rey Midas casero (Efraín Aguilar) quien ya había probado el sub-género en “Nacida para triunfar”, en el año 2008.
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Arnegard, Iver O. « Farland ». View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3353560.
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Weiand, Katrin. « Optimierung der Administrationsumgebung für Citrix-Farmen in Windows-Netzumgebungen ». Hamburg Diplomica-Verl, 2007. http://d-nb.info/988383020/04.
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Ver?ssimo, Lourena Mafra. « Desenvolvimento de nanosistemas farmac?uticos para terapia g?nica ». Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12638.
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Previous issue date: 2011-03-14Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Gene therapy is one of the major challenges of the post-genomic research and it is based on the transfer of genetic material into a cell, tissue or organ in order to cure or improve the patient s clinical status. In general, gene therapy consists in the insertion of functional genes aiming substitute, complement or inhibit defective genes. The achievement of a foreigner DNA expression into a population of cells requires its transfer to the target. Therefore, a key issue is to create systems, vectors, able to transfer and protect the DNA until it reaches the target. The disadvantages related to the use of viral vectors have encouraged efforts to develop emulsions as non-viral vectors. In fact, they are easy to produce, present suitable stability and enable transfection. The aim of this work was to evaluate two different non-viral vectors, cationic liposomes and nanoemulsions, and the possibility of their use in gene therapy. For the two systems, cationic lipids and helper lipids were used. Nanoemulsions were prepared using sonication method and were composed of Captex? 355; Tween? 80; Spam? 80; cationic lipid, Stearylamine (SA) or 1,2-dioleoyl-3-trimethylammoniumpropane (DOTAP) and water (Milli-Q?). These systems were characterized by average droplet size, Polidispersion Index (PI) and Zeta Potential. The stability of the systems; as well as the DNA compaction capacity; their cytotoxicity and the cytotoxicity of the isolated components; and their transfection capacity; were also evaluated. Liposomes were made by hydration film method and were composed of DOTAP; 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), containing or not Rhodaminephosphatidylethanolamine (PE- Rhodamine) and the conjugate Hyaluronic Acid DOPE (HA-DOPE). These systems were also characterized as nanoemulsions. Stability of the systems and the influence of time, size of plasmid and presence or absence of endotoxin in the formation of lipoplexes were also analyzed. Besides, the ophthalmic biodistribution of PE-Rhodamine containing liposomes was studied after intravitreal injection. The obtained results show that these systems are promising non-viral vector for further utilization in gene therapy and that this field seems to be very important in the clinical practice in this century. However, from the possibility to the practice, there is still a long way
A terapia g?nica ? um dos maiores desafios propostos pela pesquisa p?s-gen?mica e se baseia na transfer?ncia de material gen?tico a uma c?lula, tecido ou ?rg?o com o intuito de curar ou melhorar o estado cl?nico do paciente. Em sua forma mais simples, a terapia g?nica consiste na inser??o de genes funcionais em c?lulas com genes defeituosos objetivando substituir, complementar ou inibir esses genes causadores de doen?as. Para que o DNA ex?geno seja expresso em uma popula??o celular faz-se necess?ria a sua transfer?ncia at? o local de a??o. Assim, ? necess?rio criar ve?culos, que transportem e protejam o DNA at? que este chegue a uma popula??o celular alvo. Os obst?culos encontrados com a utiliza??o de vetores virais t?m proporcionado o interesse no desenvolvimento de vetores n?o-virais, por serem f?ceis de produzir, apresentarem estabilidade control?vel e facilitarem a transfec??o g?nica. O objetivo deste trabalho foi avaliar dois diferentes vetores n?o virais, lipossomas e nanoemuls?es cati?nicos, e sua poss?vel utiliza??o na terapia g?nica. Para isso, foram utilizados lip?deos cati?nicos e co-tensoativos na produ??o dos dois sistemas. As nanoemuls?es foram produzidas pelo m?todo de sonica??o e compostas por Captex? 355; Tween? 80; Spam? 80; lip?deo cati?nico, Estearilamina (EA) ou N-[1-(2,3-Dioleoiloxi)propil]-N,N,Ntrimetilamonio metilsulfato (DOTAP); e ?gua ultra-pura (Milli-Q?). Estes sistemas foram caracterizados quanto ao tamanho m?dio de got?cula, ?ndice de polidispers?o (PI) e potencial zeta. Avaliou-se ainda a estabilidade dos sistemas e suas capacidades de compacta??o do material gen?tico. Os lipossomas foram preparados a partir do m?todo de hidrata??o do filme e compostos por DOTAP, Dioleilfosfatidiletanolamina (DOPE), na presen?a ou aus?ncia de Rodaminafosfatidiletanolamina (PE-Rodamina) e do conjugado ?cido Hialur?nico DOPE (HA-DOPE). Estes sistemas foram caracterizados da mesma forma que as nanoemuls?es e tamb?m foram avaliados estabilidade, influ?ncia do tempo, tamanho de material gen?tico e presen?a ou aus?ncia de endotoxinas na forma??o dos lipoplexos. Os resultados obtidos permitem afirmar que os sistemas s?o promissores para posterior utiliza??o na terapia g?nica e que esta ?rea promete ser uma ?rea f?rtil de pesquisa cient?fica e cl?nica por muitos anos, e provavelmente se tornar? uma pr?tica cl?nica importante neste s?culo. No entanto, da possibilidade ? pr?tica existe um longo caminho a percorrer
15
Lishomwa, Lileko. « Anything but a head in the sand ? : pioneering ostrich farming in New Zealand : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Arts in Sociology in the University of Canterbury / ». Thesis, University of Canterbury. Sociology and Anthropology, 2007. http://hdl.handle.net/10092/995.
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The aim of this research was to identify how farmers learn how to farm using pluriactive lifestyle block ostrich farmers who are part of the New Zealand ostrich industry as a case study. Ostrich farming is comparatively new to New Zealand farmers and the industry has attracted innovative individuals who have developed informal learning strategies. Ostrich farmers use other farmers as their main resource which is mainly facilitated through events organised by the New Zealand Ostrich Association (NZOA) and aimed at lifestyle block farmers. Ostrich farmers' community of practice is centred around their membership to the Association which enables farmers to come together to learn and socialise. For learning to effectively take place the key is social interaction, where ideas can be transferred between farmers. This thesis illustrates the important events and structure of the industry and how this has shaped farmer learning. Through semi-structured interviews and participant observation on a chick rearing farm I was able to gain a picture of how lifestyle block farmers balance full time off-farm employment while running stock, in an attempt to satisfy their version of the rural idyll. The industry is now in decline as most of the early players have exited the industry and it is now focused around New Zealand Ostrich Export (NZOE) goals. By exploring the period called the breeder phase which was characterised by some farmers making a fortune as ostrich farming was the 'next big thing' and the history since then, I have identified how these particular farmers have learned how to farm.
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Nava, Farfan Analuisa [Verfasser]. « Synthese von optisch aktivem 6,11-Methylen-lipoxin B4 / Analuisa Nava Farfan ». Mainz : Universitätsbibliothek Mainz, 2016. http://d-nb.info/1119746337/34.
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Maja, Gullberg. « "Du och jag, farsan". : En genusvetenskaplig studie av fadersgestalter i "pappalitteratur" ». Thesis, Uppsala universitet, Centrum för genusvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-305444.
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This master thesis explores representations of fatherhood in the contemporary genre “daddy literature.” The study is based on four Swedish “daddy memoirs” published 2007-2010. In the genre, now adult children take a retrospective view on their relationships with their fathers, incorporating both a "child's perspective" on the father, and their present-day adult perspective. The analysis draws upon research about primary and secondary parenthood, critical studies of men and masculinities, and fatherhood studies. The analysis shows that the authors explicitly describe their fathers’ bodies. The male body is portrayed as muscular and strong, but the study shows that class, age and addiction restrict the male body. Three of the authors also describe their fathers’ as authorities that sometimes become violent. In a sense the father is the primary parent throughout the memoirs whilst the mother is usually portrayed, as the secondary parent even though she makes sure the child is properly cared for. “Daddy literature” renegotiates the power between the father and the child.
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Ver?ssimo, Lourena Mafra. « Desenvolvimento de sistemas farmac?uticos emulsionados para veicula??o g?nica ». Universidade Federal do Rio Grande do Norte, 2007. http://repositorio.ufrn.br:8080/jspui/handle/123456789/16784.
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Previous issue date: 2007-02-26Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Broadly speaking, the concept of gene therapy involves the transfer of a genetic material into a cell, tissue, or organ in order to cure a disease or at least improve the clinical status of a patient. Making it simple, gene therapy consists in the insertion of functional genes into cells containing defective genes by substituting, complementing or inhibiting them. The achievement of a foreigner DNA expression into a population of cells requires its transfer to the target. Therefore, it is a key issue to create systems able to transfer and protect the DNA until it reaches the target, the vectors. The disadvantages related to the use of viral vectors have encouraged efforts to develop emulsions as non-viral vectors. In fact, they are easily produced, present controllable stability and enable transfection. The aim of this work was to develop an emulsion for gene therapy and evaluate its ability to compact nucleic acids by the development of a complex with the plasmid pIRES2-EGFP. The first step was to determine the Hydrophilic Lipophilic Balance (HLB) of the Captex? 355 (oily internal phase of the emulsion) through long and short term stability assays. Based on the results, emulsions composed of Captex? 355, Tween 20? and Span 60? with 10.7 HLB were produced by three different methods: phase inversion, spontaneous emulsification and sonication. The results showed that the lowest diameter and best stability of the emulsions were achieved by the sonication method. The cationic emulsions were made by adding DOTAP to the basic emulsion. Its association with pIRES2-EGFP was evaluated by electrophoresis. Several rates of emulsion and DNA were evaluated and the results showed that 100% of the complex was formed when the rate DOTAP/DNA(nmol/?g) was 130. In conclusion, the overall results show the ability of the proposed emulsion to compact pIRES2-EGFP, which is a requirement to a successful transfection. Therefore, such formulation may be considered a promising candidate for gene therapy
Terapia g?nica, em uma ampla defini??o, ? o tratamento de doen?as baseado na transfer?ncia de material gen?tico a uma c?lula, tecido ou ?rg?o com o intuito de curar ou melhorar o estado cl?nico do paciente. Em sua forma mais simples, a terapia g?nica consiste na inser??o de genes funcionais em c?lulas com genes defeituosos objetivando substituir, complementar ou inibir esses genes causadores de doen?as. Para que o DNA ex?geno seja expresso em uma popula??o celular faz-se necess?ria a sua transfer?ncia at? o local. Assim, ? necess?rio criar ve?culos, os vetores, que transportem e protejam o DNA at? que este chegue a uma popula??o celular alvo. Os obst?culos encontrados com a utiliza??o de vetores virais t?m proporcionado o interesse no desenvolvimento de emuls?es cati?nicas como vetores n?o-virais, por serem f?ceis de produzir, apresentarem estabilidade control?vel e facilitarem a transfec??o g?nica. O objetivo deste trabalho foi desenvolver um sistema emulsionado para terapia g?nica e avaliar sua capacidade de compacta??o de ?cidos nucl?icos atrav?s da sua associa??o com o plasm?deo pIRES2-EGFP. Primeiramente o EHLc do TCM utilizado, o Captex? 355, foi determinado atrav?s de ensaios de estabilidade acelerada e a longo termo. Com base nos resultados obtidos, emuls?es de EHL 10,7 compostas de Captex? 355, Tween 20? e Span 60? foram preparadas pelos m?todos de invers?o de fases, emulsifica??o espont?nea e sonica??o e elegeu-se o melhor m?todo para o preparo das emuls?es cati?nicas. As emuls?es de menor granulometria e maior estabilidade foram obtidas atrav?s do m?todo de sonica??o. As emuls?es cati?nicas foram preparadas acrescendo-se ? emuls?o base o DOTAP e a sua associa??o com o pIRES2-EGFP foi avaliada atrav?s da t?cnica de eletroforese em gel de agarose. V?rias propor??es de emuls?o e DNA foram testadas e os resultados demonstraram que houve forma??o de 100% dos complexos quando a propor??o DOTAP/DNA(nmol/?g) foi igual a 130. Em conclus?o, o conjunto dos resultados obtidos demonstra a capacidade da emuls?o proposta neste trabalho de compactar o DNA, requisito necess?rio para uma boa transfec??o, tornando a formula??o uma forte candidata ? utiliza??o em terapia g?nica
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Bürger, Thomas. « Das Sehen und die Farben ». Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-33130.
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Die Ausstellung „Color continuo 1810 – 2010 System und Kunst der Farbe“ der SLUB und der AltanaGalerie der TU Dresden erinnert an die Wirkung der Farbenlehre Goethes. Die TU Dresden besitzt einen große historische Farbstoffstammlung. Goethe und Runge forschten zur Farbenlehre, und Schopenhauer arbeitete in der Königlichen öffentlichen Bibliothek in Dresden, um Goethes Farbenlehre zu vollenden. Die Ausstellung würdigt diese Arbeiten und stellt sie in einem gedruckten Katalog vor.
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Canal, Fabiana. « Profarmaci polimerici di farmaci antitumorali ». Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425020.
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Anticancer drugs are very active molecules but they present limits that often prevent their success in chemotherapy. Most common problems are low half-life, due to rapid kidney clearance and to rapid inactivation by metabolic enzymes, and low selectivity towards cancer cells that causes severe side effects. The aim of this PhD thesis is to overcome some of the limits of anticancer drugs, especially the low molecular weight ones. In particular, some polymeric conjugates were prepared by linking an anticancer drug to a polymer that acts like a carrier. Poly-(ethylene glycol) was chosen as a carrier and it was linked to two anticancer drugs: gemcitabine, an antimetabolite drug, and epirubicin, an anthracycline. The following conjugates were prepared: mPEG-gemcitabine conjugates, with different molecular weights and shapes, folate-PEG-gemcitabine conjugates, by linking the drug at one side of polymer chain and a targeting moiety at the other side. The stability at different pH values, in plasma and towards the metabolic enzyme, pharmacokinetc behaviour and cytotoxicity were studied. Some epirubicin-PEG-folate conjugates were also prepared, with different number of molecules of folic acid per polymer chain, and were compared to similar ones without folic acid. In this case the cytotoxic activity, the cellular uptake and localization were studied.
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Khalid, Farhan [Verfasser]. « Hybrid Precoding for Multiuser Multiple-Input Multiple-Output Mobile Communications / Farhan Khalid ». Aachen : Shaker, 2013. http://d-nb.info/1051575907/34.
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Oliveira, Luciane Cristina Feltrin de. « Avalia??o da asist?ncia Farmac?utica b?sica no SUS municipal ». UNIVERSIDADE ESTADUAL DE FEIRA DE SANTANA, 2007. http://localhost:8080/tede/handle/tede/41.
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Persson, Alva Andersdotter, et Melina Westerberg. « Dör faran med gärningsmannen ? : En kvalitativ framinganalys av skolattentatet i Trollhättan ». Thesis, Linnéuniversitetet, Institutionen för medier och journalistik (MJ), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-59866.
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In October 2015, a masked man armed with a sword and a knife entered the school Kronan in the Swedish town Trollhättan. Four people, including the perpetrator, were killed and another two severely injured. The aim of this study is to examine the frames in medias description of the event and of the perpetrator from the view of the journalistic responsibilities. The event in Trollhättan can be seen as an act of terror and during such events the journalistic responsibilities sometimes changes. There is a conflict in the aspect of telling the truth on one hand and protecting the citizens from harm on the other, in order not to reproduce the terrorist’s message in the press. This study is a qualitative framing analysis of 11 articles from the local newspaper TTELA. We found that the most salient frame of the event was grief rather than drama and that the media acted on the responsibility of protecting the citizens from details. The perpetrator was described as a lone wolf with connections to racist groups on the Internet. There was a shallow frame regarding the danger with the groups on the Internet but the main problem was described as gone with the death of the lonely perpetrator.
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Fellnerová, Petra. « Rodinná farma a její pozice ve venkovském prostoru : Historie a současnost ». Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-260312.
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Family farms have irreplaceable place in the history of our society. The aim of this thesis was to find out how the selected family farms in rural areas have changed their position in the course of historical development. The thesis also supplements the theoretical knowledge of family farms.
This thesis is divided into two parts. The first part contains a review of literature related to the rural areas, agriculture and family farms. The research is based on interviews with the owners of selected family farms. The acquired information is supplemented with data from the survey, which took place in the context of sales events organized by family farms. Respondents answered questions about their relationship to a particular family farm and expressed opinions on the family farm in general.
The thesis confirmed the stated hypotheses that family farms have a stable position in rural areas, are actively involved in the protection of nature and landscape and their activities are positively perceived by the public. It has not confirmed the hypothesis that the owners of family farms reflect the improvement in the status of family farms in rural areas now than in the past.
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Eleftheriou, Georgios. « Uso di farmaci Antidepressivi Inbitori del Reuptake della Serotonina, di farmaci Antiepilettici e di Retinoidi in Gravidanza ». Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425534.
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After the catastrophic event of thalidome in Europe, early in the sixties, the FDA planed experimental protocols for the study of the reproduction toxicity of drugs and other substances.
In this work, we begun our route from the fecundation to the normal fetal development and the principles of developmental toxicology. We reported an outline of the pathogenesis of developmental toxicity and we mentioned the sources of the teratogenic evaluation: animal experiments and epidemiologic data.
Finally, we refer the follow-up interview; this interview consisted of a comprehensive list of questions with regard to maternal health during pregnancy, pregnancy outcome, delivery, and neonatal health.
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Gerlack, Leticia Farias. « Assist?ncia farmac?utica em institui??o de longa perman?ncia para idosos ». Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2012. http://tede2.pucrs.br/tede2/handle/tede/2669.
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Previous issue date: 2012-03-20To evaluate the Pharmaceutical Services process in nursing homes we conducted a cross-sectional observational study. The sample was selected by convenience, with all elderly residents who were using drugs. The research began only after the project approval by the PUCRS Ethics Committee in Research, number 10/05111. Data collection was performed between August 2010 and April 2011 and consisted of questions about residents' health, drugs used and their satisfaction with pharmaceutical care, as well as medicine products storage. Data was collected by reviewing nursing home medical records, medicine purchase receipts and interviews with residents and nursing homes professionals and observation of the researcher. For the satisfaction was considered the minimum level score 05 points and 25 points for the highest degree, from the responses of the specific questionnaire applied to the elderly. In the collection period, 113 of the elderly residing in ILPI only two were iv excluded because they were not on use any medications. The average residence time of 111 elderly was 6.3 ? 7.5. Most (74.1%) was composed of women, the mean age was 81.5 ? 7.7 years. The average consumption of drugs was 5.2 ? 2.33. According to the Beers criteria, 27 (24.3%) prescriptions contained inappropriate drugs and 51 (45.9%) at least one drug without problem described in the medical records to justify its use. In 40 (36%) prescriptions were observed 99 drug interactions. Those classified as moderate severity were the most frequent (64.9%), followed by gravity high (22.9%). These frequencies were elevated compared with other studies in nursing homes in Brazil and abroad, especially those of greater severity. The storage conditions of medications were far from desirable, where most of the expected quality criteria were not met. The drugs were in a high humidity location, in the presence of mold, many in boxes placed in direct contact with the ground, and without any control records. A wide range of problems concerning all the processes related to the pharmaceutical care was observed, from the purchase to the final use by the elderly. The average satisfaction with pharmaceutical care among women (18.5 ? 2.02) and men (18.93 ? 2.37) was similar, indicating that gender did not influence the degree of satisfaction with care (p = 0.573). The linear regression of satisfaction and age showed a positive relationship in which older residents had higher levels of satisfaction, although this relationship was not significant (p = 0.558). During the period of one year were purchased by the institution 107 different types of drugs, among which 22 (20.6%) could have been accessed for free Health System or the Popular Pharmacy of Brazil program, which equates to a saving of R $ 7,721.52 (29.4%) for the institution. In detailing many problems observed in this study and the complexity of the pharmaceutical services process, whether related to the purchase, access, storage, distribution and use, was identified the need for inclusion of the pharmacist in nursing homes teams working in Brazil. As has been occurring in foreign countries, the presence of a pharmacist generates positive impacts both nursing homes and their elderly residents, and consequently to the health system.
Para avaliar as a??es relacionadas ao ciclo da Assist?ncia Farmac?utica em Institui??o de Longa Perman?ncia para Idosos (ILPI) foi realizado um estudo transversal, descritivo e anal?tico. A amostra foi selecionada por conveni?ncia, constituindo-se por todos os idosos residentes que faziam uso de medicamentos. A pesquisa iniciou somente aprova??o do projeto pelo Comit? de ?tica em Pesquisa da PUCRS, sob registro 10/05111. A coleta de dados foi realizada entre agosto de 2010 e abril de 2011 e orientada por um instrumento contendo quest?es referentes ? sa?de dos resiGdentes, aos medicamentos utilizados e ? sua satisfa??o com a assist?ncia farmac?utica, bem como ?s condi??es do acondicionamento dos medicamentos. A coleta constitui-se de pesquisas em prontu?rio, em notas fiscais de compras de medicamentos, entrevistas com os idosos e com profissionais da ILPI e de observa??o da pesquisadora. Quanto ? satisfa??o, foi considerado grau m?nimo o escore de 05 pontos e 25 pontos para grau m?ximo, a partir das respostas do question?rio espec?fico aplicado aos idosos. No per?odo da coleta, dos 113 idosos que residiam na ILPI apenas dois foram exclu?dos por n?o estarem utilizando algum medicamento. A maioria (74,1%) foi composta por mulheres e a m?dia de idade foi 81,5 ? 7,7 anos. O consumo m?dio de medicamentos foi 5,2 ? 2,33. De acordo com os Crit?rios de Beers, 27 (24,3%) das prescri??es continham medicamentos inapropriados e 51 (45,9%) no m?nimo, um medicamento sem problema descrito em prontu?rio que justificasse seu uso. Em 40 (36%) das prescri??es foram observadas 99 intera??es medicamentosas. As classificadas como de gravidade moderada foram as mais frequentes (64,9%), seguidas das de gravidade alta (22,9%). Estas frequ?ncias foram elevadas, quando comparadas com estudos realizados em ILPIs no Brasil e exterior, sobretudo as de maior gravidade. As condi??es de estocagem dos medicamentos estavam muito aqu?m do desej?vel, onde a maioria dos crit?rios de qualidade esperados n?o foi atendida. Os medicamentos encontravam-se em local ?mido, com presen?a de mofo, muitos em caixas dispostas diretamente em contato com o ch?o, sem quaisquer registros de controle de estoque. Uma ampla gama de problemas quanto aos processos relacionados ao ciclo da assist?ncia farmac?utica foi observada, desde a aquisi??o de medicamentos at? a sua utiliza??o pelos idosos. A m?dia de satisfa??o com a assist?ncia farmac?utica entre as mulheres (18,5 ? 2,02) e os homens (18,93 ? 2,37) foi semelhante, indicando que o iii sexo n?o influenciou o grau de satisfa??o quanto ? assist?ncia (p=0,573). A regress?o linear do grau de satisfa??o e da idade mostrou uma rela??o positiva na qual os residentes mais idosos apresentaram n?veis de satisfa??o mais elevados, embora esta rela??o n?o tenha sido significativa (p=0,558). Durante o per?odo de um ano foram adquiridos pela institui??o 107 diferentes tipos de f?rmacos, entre os quais, 22 (20,6%) poderiam ter sido acessados gratuitamente atrav?s do Sistema ?nico de Sa?de ou pelo programa Farm?cia Popular do Brasil, o que corresponderia a uma economia de R$ 7.721,52 (29,4%) para a institui??o nesse per?odo. Os in?meros problemas observados neste estudo poderiam servir de alerta ?s autoridades no sentido de definir melhores indicadores da assist?ncia farmac?utica nestes locais, bem como qualificar a rede de assist?ncia ? sa?de aos residentes. Em face da complexidade dos processos relacionados ao uso de medicamentos, sejam eles relacionados ? aquisi??o, acesso, armazenamento, estoque, distribui??o e utiliza??o, percebe-se a necessidade da inclus?o do farmac?utico nas equipes que atuam em ILPIs brasileiras, como j? vem ocorrendo em pa?ses estrangeiros, gerando impactos positivos tanto as ILPIs, quanto aos idosos residentes e, consequentemente ao sistema de sa?de.
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Goularte, Juliana Henriques. « As dimens?es da qualidade do relacionamento no contexto do mercado farmac?utico ». Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2009. http://tede2.pucrs.br/tede2/handle/tede/5580.
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Previous issue date: 2009-08-31Os aspectos intang?veis de um relacionamento s?o dif?ceis de serem copiados pelos concorrentes, proporcionando assim uma vantagem competitiva sustent?vel para as empresas que se preocupam com o desenvolvimento da qualidade do relacionamento. A partir da revis?o dos trabalhos realizados sobre qualidade do relacionamento, identificou-se a necessidade em entender os motivos respons?veis pela sua forma??o. Com base no modelo das dimens?es da qualidade do relacionamento validado por Roberts, Varki e Brodie (2003), realizou-se uma pesquisa de natureza qualitativa, junto a m?dicos e representantes de medicamentos, com o objetivo de entender os motivos das rela??es entre satisfa??o, comprometimento, confian?a, conflito afetivo e qualidade do relacionamento, no contexto da ind?stria farmac?utica. A an?lise de conte?do das entrevistas proporcionou um conjunto de achados relevantes para entender os motivos que permeiam as rela??es em quest?o. Para a rela??o entre satisfa??o e qualidade do relacionamento, os motivos encontrados foram os benef?cios acumulados durante intera??es passadas e o envolvimento. Quanto ? rela??o entre comprometimento e qualidade do relacionamento, os motivos apresentados foram a neglig?ncia de informa??es negativas por parte dos concorrentes, os custos de mudan?a e os benef?cios econ?micos. J? para a rela??o entre confian?a e qualidade do relacionamento, s?o apresentados os benef?cios da confian?a, a troca de conhecimentos e a similaridade de valores com os representantes como os motivos que permeiam esta rela??o. Para a rela??o entre conflito afetivo e qualidade do relacionamento, os motivos apresentados foram os benef?cios sociais e a coopera??o. Por fim, apresentam-se as implica??es acad?micas e gerenciais dos resultados obtidos, bem como suas limita??es e sugest?es para pesquisas futuras decorrentes da realiza??o deste estudo
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Cabe, Carolina Moraes. « Determina??o de par?metros de qualidade para formas farmac?uticas homeop?ticas ». Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13466.
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Previous issue date: 2012-02-10All medicine, whether allopathic or homeopathic, must go through strict quality control, which must ratify their characteristics throughout the period of validity. During the time of preparation and storage, solutions of the drugs are in permanent contact with packaging materials that can release undesirable substances to the solution. Several factors may influence the release of packing materials, and factorial design (FD) is a useful tool for analyzing the phenomenon. The aim of this study was the determination of quality parameters for Homeopathic solid (globules) and liquid (drops) dosage forms. It was carried out analysis in homeopathic globules for weight variation, mechanical strength, and moisture content uniformity. For liquid preparations, standard solutions were prepared from natural rubber bulbs, which were subjected to exhaustive extraction with two ethanol solutions (30 and 70%) in the ultrasonic bath for 20 minutes at 25?C and 50?C in three successive cycles. Studies of transfer have been made within five days, by spectrophotometric analysis in the UV region at 312 nm with λm?x and 323 nm for samples in 70% ethanol and 30% respectively. PH values were analyzed. We also conducted two FD studies, where the first, the three-level variables were solvent (chloroform, ethanol and nhexane), sample mass (30, 60 and 90mg), particle size (large disk, small disk and powder sample). In the second study, the solvent level variables were different ethanolic degrees (EtOH 30%, 70% and pure). The percentage of lending in the solutions was 5.5%, 12.4%, 24.2% and 41% of the total estimated in the reference solution. The values of rate constants of transfer were determined in the order of 0.0134 days-1 and 0.0232 days-1 in absorbance values, the solutions in ethanol at 30% and 70% respectively. These results suggest that the speed of transfer of materials from rubber is affected both by the nature of the vehicle as by the temperature
Todo medicamento, quer seja alop?tico ou homeop?tico, deve passar por rigoroso controle de qualidade, o qual deve ratificar as suas caracter?sticas ao longo de todo o per?odo de validade. Durante o tempo de preparo e armazenamento, as solu??es dos medicamentos est?o em contato permanente com os materiais de embalagem que podem liberar subst?ncias indesej?veis para a solu??o. V?rios fatores podem influenciar a libera??o de materiais da embalagem, e planejamento fatorial (PF) ? uma ferramenta ?til para analisar o fen?meno. O objetivo deste trabalho foi a determina??o de par?metros de qualidade para Formas Farmac?uticas Homeop?ticas s?lidas (gl?bulos) e liquidas (gotas). Foi efetuada a avalia??o dos gl?obulos homeop?ticos no que diz respeito ? sua varia??o de peso, testes de resist?ncia mec?nica, uniformidade de conte?do e umidade. Para as prepara??es liquidas, preparamos solu??es de refer?ncia a partir de bulbos de borracha natural, os quais foram submetidos ? extra??o exaustiva com duas solu??es de etanol (30 e 70%), em banho de ultrassom durante 20 minutos a 25?C e 50?C, em tr?s ciclos sucessivos de 24 horas. Os estudos de ced?ncia foram efetuados num tempo de cinco dias, atrav?s de an?lise espectrofotom?trica na regi?o UV com λm?x em 312 nm e 323 nm para as amostras em etanol a 70% e 30%, respectivamente. Foram verificados valores de pH. Foram tamb?m realizados dois estudos de PF, onde no primeiro, as tr?s vari?veis de n?vel foram solvente (clorof?rmio, etanol e n-hexano), massa de amostra (30, 60 e 90mg), a forma de amostra (grande disco, disco pequeno, a amostra em p?). No segundo estudo, as vari?veis de n?vel solvente foram gradua??es etan?licas diferentes (EtOH 30%, 70% e puro). O percentual de ced?ncia nas solu??es foi de 5,5%, 12,4%, 24,2% e 41% do total estimado na solu??o de refer?ncia. Os valores das constantes de velocidade de ced?ncia foram determinados na ordem de 0,0134 dia-1 e 0,0232 dia-1, em valores de absorb?ncia, nas solu??es em etanol a 30% e 70%, respectivamente. Esses resultados sugerem que a velocidade de ced?ncia de materiais a partir da borracha ? afetada tanto pela natureza do ve?culo como pela temperatura
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Rybak, Katarzyna [Verfasser], Farhah [Akademischer Betreuer] [Gutachter] Assaad-Gerbert et Jörg [Gutachter] Durner. « Tethering complexes required for plant cytokinesis / Katarzyna Rybak ; Gutachter : Jörg Durner, Farhah Assaad-Gerbert ; Betreuer : Farhah Assaad-Gerbert ». München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1120584175/34.
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Marczal, Diego. « FARMA : uma ferramenta de autoria para objetos de aprendizagem de conceitos matemáticos ». reponame:Repositório Institucional da UFPR, 2014. http://hdl.handle.net/1884/37363.
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Orientador : Prof. Dr. Alexandre Ibraim DireneCoorientador : Prof. Dr. Andrey Ricardo Pimentel
Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Exatas, Programa de Pós-Graduação em Informática. Defesa: Curitiba, 24/11/2014
Inclui referências
Resumo: Atualmente a tecnologia é fundamental para o processo de ensino e aprendizagem, sendo uma das abordagens de destaque o uso dos Objetos de Aprendizagem. A partir desta óptica, esta pesquisa desenvolveu uma ferramenta web de autoria para Objetos de Aprendizagem, que permite a manipulação dos registros de erros na prática docente por meio de um mecanismo que possibilita a retroação ao contexto de erros e acertos dos aprendizes. Dessa forma, argumenta-se que o armazenamento, a visualização, a manipulação e a recuperação de registros de erros e também de acertos dos aprendizes podem trazer benefícios para o ensino e aprendizagem. Neste trabalho, o problema de construção de Objetos de Aprendizagem com ferramentas de autoria é exposto de maneira crítica. As principais limitações das abordagens atuais do ensino de matemática com Objetos de Aprendizagem são apontadas na resenha literária. Uma ferramenta web de autoria, chamada FARMA, com enfoque no conceito de mobilidade tecnológico-educacional, é apresentada como alternativa às abordagens pedagógicas existentes que se apoiam em aparatos tecnológicos. A teoria ACT (Adaptive Control of Thought) embasou o modelo de criação e apresentação de exercícios do arcabouço proposto. O erro do aprendiz é destacado como abordagem cognitivista central da aprendizagem no contexto da atual versão da FARMA. A avaliação do processo de autoria foi realizada por meio de estudos empíricos focados na simplicidade de criar Objetos de Aprendizagem matemáticos. O experimento realizado para avaliação de uma nova abordagem de trabalhar com o erro dos aprendizes em Objetos de Aprendizagem se deteve na sua utilização por professores e aprendizes, assim como, nos potenciais ganhos para ensino e aprendizagem. Os resultados mostram que o arcabouço apresentado, com a proposta da utilização dos erros no processo de aquisição de conhecimento, fundamentalmente diferente das encontradas em ambientes educacionais, têm grandes potencialidades para o ensino e aprendizagem. Palabras-chave: Retroação a Erros, Ambientes de Autoria, Objetos de Aprendizagem.
Abstract: Nowadays the technology is essencial to the process of teaching and learning and one of the prominent approaches is the use of Learning Objects. Seeing that, the research developed a web authoring tool to Learning Objects, which allows the manipulation of the error records in the teaching practice through retroaction mechanism that allows going back to the context of correct and wrongs interactions of apprentices. Thus, it is argued that the storage, visualization, manipulation, and retrieval of errors records and also correct interaction of the learners can bring benefits for teaching and learning. In this thesis, the problem of building learning objects with authoring tools is exposed in a critical way. The main limitations of current approaches to mathematics teaching with learning objects are pointed out in the literature review. A web authoring tool, called FARMA, focusing on the concept of techno-educational mobility, is presented as an alternative to existing pedagogic approaches that rely on technological devices, the theory Adaptive Control of Thought guided the fellowship model creation and presentation of the proposed framework exercises. The mistakes of the learner are highlighted as a central cognitive approach of learning in the current version of FARMA. The evaluation of the authoring tool was done as an empirical study focused on simplicity to create mathematical Learning Objects. The experiment conducted to evaluate a new approach of working with errors in Learning Objects focused in the use by teachers and learners and their potential benefits for teaching and learning. The results show that the framework developed with the proposed use of errors in the acquisition of knowledge, fundamentally di
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BRAGA, Jovita Maria de Farias. « Estudo farma cognóstico de duas espécies de Priva de ocorrência em Pernambuco ». Universidade Federal de Pernambuco, 2007. https://repositorio.ufpe.br/handle/123456789/3568.
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Previous issue date: 2007O gênero Priva é de distribuição tropical e está bem representado em nosso país por duas espécies: a Priva bahiensis A. DC., nativa e a Priva lappulacea (L) Pers.. Ambas são herbáceas terrestres do grupo dos carrapichos e se desenvolvem em terrenos úmidos e semi-ensombreados, sem possuírem um aroma acentuado, traço comum a muitas Verbenaceae. A forte presença, sobretudo de P. lappulacea , nos domínios do Campus e a falta de citações na literatura pertinente sobre suas características farmacognósticas e de bioatividade nos impulsionou a feitura desse trabalho, de forma a valorizar espécies locais com possíveis potencialidades de emprego como insumo farmacêutico. Após caracterização botânica das duas espécies, efetuamos um diagnóstico mais profundo de P. lappulacea , por existir em maior abundância, proporcionando mais fácil aquisição de material para as diversas investigações que foram desenvolvidas. Um estudo farmacobotânico direcionado à anatomia e histo-química desse táxon foi desenvolvido, resultando na obtenção de dados ainda inéditos para o mesmo. Além da definição de um perfil fitoquímico para os dois taxa, onde se constatou a predominância de glicosídeos de fenilpropanóides e de iridóides, caracterizando-se por procedimentos e/ou espectroscópicos o verbascosídeo, a ipolamida e o catalpol. Os ensaios de bioatividade realizados especialmente com material oriundo de P. lappulacea foram direcionados à definição de sua toxicidade e potencialidades como antiinflamatório, antitumoral e antimicrobiano, proporcionando resultados promissores quanto aos mesmos
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Shirvani, Fardad [Verfasser]. « Optimierung des Rechtsschutzes im Vergaberecht / Fardad Shirvani ». Baden-Baden : Nomos Verlagsgesellschaft mbH & ; Co. KG, 2016. http://d-nb.info/1106288831/34.
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Coghi, P. S. « Sintesi e meccanismo d'azione dei farmaci antimalarici ». Doctoral thesis, Università degli Studi di Milano, 2008. http://hdl.handle.net/2434/154294.
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Malaria nowadays remains one of the world’s greatest public health problems, especially in the developing countries. Despite numerous efforts expended to reduce its mortalityand morbidity,[1] malaria still threatens approximately 2 billion people worldwide, being responsible for almost two million deaths per year, mostly among young children in sub-Saharan Africa.[2] Among the four malaria species that infect humans, the parasite P. falciparum is universally considered the most aggressive. Particularly impressive is its ability in mutating forms in response to administered antiplasmodial treatment, rapidly giving rise to adaptation and resistance. 4-Aminoquinolines have recently been indicated to be an important class of chemotherapeutic agents for artemisinin based antimalarial combination therapy. A rapid, cheap, possibly clean and scalable route to 4-aminoquinolines endowed with multiple diversity is therefore badly needed. We here report microwave flash-heating chemistry to allow the efficient conversion of the available 4,7-dichloroquinoline into a library of aminoquinolines in high yields and purities, with no need for further purification steps and requiring very short reaction times. Some of the compounds in this library were active against chloroquine-sensitive and chloroquine-resistant parasite strains. [3].The combined use of conventional SNAr reaction and microwave irradiation is another approach developed, proved very valuable in producing derivatized triazines with tunable substituents. A library of 2,4,6-triamino-1,3,5-triazines was synthesized as both cycloguanil and chloroquine analogues, and were assessed in terms of in vitro antimalarial activity and toxicity. [4] [5]Some of the compounds in this library showed higher activity against CQ-resistant parasite strains
and some exhibited CQ-sensitive activity in the same order as chloroquine itself.
Another important parts of this thesis was study mechanism of action of peroxide compounds.
We have demonstrated that a non metallic reagent such a leucomethylene blue is capable of efficiently activating a series of endoperoxides compounds including dioxanes, trioxanes and tetraoxanes. In principle our results suggest that is possible to hypothesize the existence of a unique common activator at the biological level inducing devastating effect toward parasite survival.The present work puts under discussion the assumption of the roles of iron and C center radical in the mechanism of action of antimalarial drugs based on artemisinin derivatives , and paves the way towards a new interpretation of the biological evidences so far.[7,8]
We also demonstrated that In line with the enhancement of antimalarial activities of the current clinical artemisinins against parasites cultured under CO, the artemisinins are unaffected in vitro by carboxyhemoglobin (CO–Hb–FeII) or CO–heme–FeII, but are competitively decomposed by Hb–FeII or heme–FeII. In the latter case, the heme studies are greatly facilitated by solubilization of the heme in aqueous medium by use of arginine. None of the Hb species has an appreciable effect on artemisone, or on other aminoartemisinins, and antimalarial activities are either less affected or remain essentially unchanged against parasites cultured under standard microaerophilic conditions or under CO.The findings not only indicate that artemisinins do not require Hb–FeII or heme–FeII for promotion of antimalarial activity, but are also important in relation to the therapy of severe/complicated or cerebral malaria.[6]
References
[1] World Health Organization 2006: http://www.rollbackmalaria.org/malariaFAQ.html.[2] C. A. Swales, P. L. Chiodini, B. A. J. Bannister, Infect. 2007,54, 107–110; b) D. A. van Schalkwyk, T. J. Egan, Drug Resist.Updates 2006, 9, 211–226.[3] S. Melato, P. Coghi, N. Basilico, D. Prosperi, D. Monti, “Novel 4-Aminoquinolines through Microwave-Assisted SNAr Reactions: a Practical Route Antimalarial Agents”.Eur. J. Org. Chem. 2007, 6118–6123. [4] S.Melato, D.Prosperi, P.Coghi, N.Basilico, and D.Monti. “A Combinatorial Approach to 2,4,6-Trisubstituted Triazines with Potent Antimalarial Activity: Combining Conventional Synthesis and Microwave-Assistance” ChemMedChem,2008, 1 – 4.[5] Expert Meeting COST B22 "DRUG DISCOVERY & DEVELOPMENT FOR PARASITIC DISEASES", Modena, Italy, 19-20 February 2007.[6] Coghi, P. ; Basilico, N. ; Wing-Chi Chan ; Haynes K.R. ; Taramelli ;Monti D. Interaction of Artemisinins with Oxyhemoglobin Hb-FeII, Hb-FeII, CarboxyHb-FeII, Heme-FeII, and Carboxyheme FeII: Significance for Mode of Action and Implications for Therapy of Cerebral Malaria Chemmedchem .2009 [7] Richard K. Haynes, Kwan-Wing Cheu, Maggie Mei-Ki Tang, Min-Jiao Chen, Zu-Feng Guo, Zhi-Hong Guo, Paolo Coghi, Diego Monti Reactions of Antimalarial Peroxides with Each of Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model Exemplified.. Chemmedchem .2011[8] Richard K. Haynes,Wing-Chi Chan,Ho-Ning Wong, Ka-Yan Li, Wai-Keung Wu, Kit-Man Fan, Herman H. Y. Sung, Ian D. Williams, Davide Prosperi, Sergio Melato,Paolo Coghi, and Diego Monti Facile Oxidation of Leucomethylene Blue and Dihydroflavins by Artemisinins: Relationship with Flavoenzyme Function and Antimalarial Mechanism ofAction,ChemMedChem. 2010, 1-19
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Airo, Juha. « Role of cerebral dopamine and noradrenaline in locomotor sensitization to morphine in mice ». Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/airio/.
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Honkanen, Aapo. « Modulation of brain dopaminergic neurotransmission in alcohol-preferring rats by alcohol and opioids ». Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/honkanen/.
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Summanen, Jari Olavi. « A chemical and ethnopharmacological study on Phyllanthus emblica L. (Euphorbiaceae) ». Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/summanen/.
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Lautala, Pia. « Catechol O-methyltransferase : glucuronidation of inhibitors and methylation of substates ». Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/lautala/.
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Parkkisenniemi, Ulla-Mari. « Factors affecting the tone of the bovine retractor penis muscle with special reference to endothelins ». Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/parkkisenniemi/.
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Rantanen, Jukka. « Near-infrared reflectance spectroscopy in the measurement of water as a part of multivariate process monitoring of fluidised bed granulation process ». Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/rantanen/.
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Salminen, Outi. « Effect of nicotine on dopaminergic neurotransmission and expression of fos protein ». Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/salminen/.
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Westermarck, Sari. « Use of mercury porosimetry and nitrogen adsorption in characterisation of the pore structure of mannitol and microcrystaline cellulose powders, granules and tablets ». Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/westermarck/.
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Halsas, Marikki. « Development and biopharmaceutical evaluation of press-coated tablets taking account of circadian rhythms of disease ». Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/halsas/.
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Mikkola, Janne. « Role of brain dopamine in psychomotor stimulation induced by morphine and cocaine in alcohol-preferring and alcohol-avoiding rats ». Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/mikkola/.
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Ojala, Tiina. « Biological screening of plant coumarins ». Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/ojala/.
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Peltonen, Leena. « The interfacial behaviour of sorbitan surfactant monolayers and the bulk properties of these surfactants as a function of temperature ». Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/peltonen/.
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Rauha, Jussi-Pekka. « The search for biological activity in Finnish plant extracts containing phenolic compounds ». Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/rauha/.
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Seppä, Tiina. « Role of nicotinic acetylcholine receptors in cerebral dopaminergic transmission and expression of Fos protein ». Helsinki : University of Helsinki, 2001. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/seppa/.
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Christiansen, Leena I. « Preparation, analysis and cholesterol lowering effect of a novel microcrystalline b[beta]-sitosterol suspension in oil and phase behaviour of b[beta]-sitosterol with cholesterol ». Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/christiansen/.
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Gäddnäs, Helena. « Long-term oral nicotine treatment and daily variations in brain monoamines and motor activity ». Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/gaddnas/.
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Kankaanpää, Aino. « The effects of psychostimulant drugs on brain dopaminergic and serotonergic neuronal systems : the role of 5-HT3 receptors ». Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/kankaanpaa/.
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