Bibliographies thématiques / F11A

Littérature scientifique sur le sujet « F11A »

Auteur : Grafiati
Publié le 11 mars 2023

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Articles de revues sur le sujet "F11A"

1

Ottaviano, Emerenziana, Elisa Borghi, Laura Giovati, Monica Falleni, Delfina Tosi, Walter Magliani, Giulia Morace, Stefania Conti et Tecla Ciociola. « Therapeutic Effect of an Antibody-Derived Peptide in a Galleria mellonella Model of Systemic Candidiasis ». International Journal of Molecular Sciences 22, no 20 (9 octobre 2021) : 10904. http://dx.doi.org/10.3390/ijms222010904.

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The synthetic peptide T11F (TCRVDHRGLTF), with sequence identical to a fragment of the constant region of human IgM, and most of its alanine-substituted derivatives proved to possess a significant candidacidal activity in vitro. In this study, the therapeutic efficacy of T11F, D5A, the derivative most active in vitro, and F11A, characterized by a different conformation, was investigated in Galleria mellonella larvae infected with Candida albicans. A single injection of F11A and D5A derivatives, in contrast with T11F, led to a significant increase in survival of larvae injected with a lethal inoculum of C. albicans cells, in comparison with infected animals treated with saline. Peptide modulation of host immunity upon C. albicans infection was determined by hemocyte analysis and larval histology, highlighting a different immune stimulation by the studied peptides. F11A, particularly, was the most active in eliciting nodule formation, melanization and fat body activation, leading to a better control of yeast infection. Overall, the obtained data suggest a double role for F11A, able to simultaneously target the fungus and the host immune system, resulting in a more efficient pathogen clearance.
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Massie, Steven T., A. Goldman, David G. Murcray et John C. Gille. « Approximate absorption cross sections of F12, F11, C1ONO_2, N_2O_5, HNO_3, CCl_4, CF_4, F21, F113, F114, and HNO_4 ». Applied Optics 24, no 21 (1 novembre 1985) : 3426. http://dx.doi.org/10.1364/ao.24.003426.

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Pertinhez, Thelma A., Tecla Ciociola, Laura Giovati, Walter Magliani, Silvana Belletti, Luciano Polonelli, Stefania Conti et Alberto Spisni. « Dissection of the Structural Features of a Fungicidal Antibody-Derived Peptide ». International Journal of Molecular Sciences 19, no 12 (28 novembre 2018) : 3792. http://dx.doi.org/10.3390/ijms19123792.

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The synthetic peptide T11F (TCRVDHRGLTF), derived from the constant region of human IgM antibodies, proved to exert a significant activity in vitro against yeast strains, including multidrug resistant isolates. Alanine substitution of positively charged residues led to a decrease in candidacidal activity. A more dramatic reduction in activity resulted from cysteine replacement. Here, we investigated the conformational properties of T11F and its alanine-substituted derivatives by circular dichroism (CD) and nuclear magnetic resonance (NMR) spectroscopy. Peptide interaction with Candida albicans cells was studied by confocal and scanning electron microscopy. T11F and most of its derivatives exhibited CD spectra with a negative band around 200 nm and a weaker positive band around 218 nm suggesting, together with NMR coupling constants, the presence of a polyproline II (PPII) helix, a conformational motif involved in a number of biological functions. Analysis of CD spectra revealed a critical role for phenylalanine in preserving the PPII helix. In fact, only the F11A derivative presented a random coil conformation. Interestingly, the loss of secondary structure influenced the rate of killing, which turned out to be significantly reduced. Overall, the obtained results suggest that the PPII conformation contributes in characterising the cell penetrating and fungicidal properties of the investigated peptides.
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Kobayashi, Hiyori, Teizo Asano, Tomohiro Tanaka, Hiroyuki Suzuki, Mika K. Kaneko et Yukinari Kato. « Determination of the Binding Epitope of an Anti-Mouse CCR9 Monoclonal Antibody (C9Mab-24) Using the 1× Alanine and 2× Alanine-Substitution Method ». Antibodies 12, no 1 (31 janvier 2023) : 11. http://dx.doi.org/10.3390/antib12010011.

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C-C chemokine receptor 9 (CCR9) is a receptor for C-C-chemokine ligand 25 (CCL25). CCR9 is crucial in the chemotaxis of immune cells and inflammatory responses. Moreover, CCR9 is highly expressed in tumors, including several solid tumors and T-cell acute lymphoblastic leukemia. Several preclinical studies have shown that anti-CCR9 monoclonal antibodies (mAbs) exert antitumor activity. Therefore, CCR9 is an attractive target for tumor therapy. In this study, we conducted the epitope mapping of an anti-mouse CCR9 (mCCR9) mAb, C9Mab-24 (rat IgG2a, kappa), using the 1× alanine (1× Ala)- and 2× alanine (2× Ala)-substitution methods via enzyme-linked immunosorbent assay. We first performed the 1× Ala-substitution method using one alanine-substituted peptides of the mCCR9 N-terminus (amino acids 1–19). C9Mab-24 did not recognize two peptides (F14A and F17A), indicating that Phe14 and Phe17 are critical for C9Mab-24-binding to mCCR9. Furthermore, we conducted the 2× Ala-substitution method using two consecutive alanine-substituted peptides of the mCCR9 N-terminus, and showed that C9Mab-24 did not react with four peptides (M13A–F14A, F14A–D15A, D16A–F17A, and F17A–S18A), indicating that 13-MFDDFS-18 is involved in C9Mab-24-binding to mCCR9. Overall, combining, the 1× Ala- or 2× Ala-scanning methods could be useful for understanding for target–antibody interaction.
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Babinska, Anna, Bani Azari, Moro Salifu, Ruijie Liu, Xian-Cheng Jiang, Malgorzata Sobocka, Dorothy Boo et al. « The F11 receptor (F11R/JAM-A) in atherothrombosis : Overexpression of F11R in atherosclerotic plaques ». Thrombosis and Haemostasis 97, no 02 (2007) : 272–81. http://dx.doi.org/10.1160/th06-08-0454.

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SummaryF11R is the gene name for an adhesion protein, called the F11-receptor, aka JAM-A, which under normal physiological conditions is expressed constitutively on the surface of platelets and localized within tight junctions of endothelial cells (EC). Previous studies of the interactions between human platelets and EC suggested that F11R/JAM-A plays a crucial role in inflammatory thrombosis and atherosclerosis. The study reported here obtained in-vivo confirmation of this conclusion by investigating F11R/JAM-A protein and mRNA in patients with aortic and peripheral vascular disease and in an animal model of atherosclerosis. Molecular and immunofluorescence determinations revealed very high levels of F11R/JAM-A mRNA and F11R/JAM-A protein in atherosclerotic plaques of cardiovascular patients. Similar results were obtained with 12-week-old atherosclerosis-prone apoE-/- mice, an age in which atherosclerotic plaques are well established. Enhanced expression of the F11R/JAM-A message in cultured EC from human aortic and venous vessels was observed following exposure of the cells to cytokines. Determinations of platelet adhesion to cultured EC inflamed by combined cytokine treatment in the presence of F11R/JAM-A – antagonists provided data indicating that de novo expression of F11R/JAM-A on the luminal surface of inflamed EC has an important role in the conversion of EC to a thrombogenic surface. Further studies of these interactions under flow conditions and under in-vivo settings could provide a final proof of a causal role for F11R/JAM-A in the initiation of thrombosis. Based on our invitro and in-vivo studies to date, we propose that therapeutic drugs which antagonize the function of F11R/JAM-A should be tested as novel means for the prevention and treatment of atherosclerosis, heart attacks and stroke.
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Babinska, Anna, Tahir Ahmed, Olcay Batuman, Yigal Ehrlich, M. Hussain, Mamdouh Kedees, Humra Athar et Elizabeth Kornecki. « F11-Receptor (F11R/JAM) Mediates Platelet Adhesion to Endothelial Cells : Role in Inflammatory Thrombosis ». Thrombosis and Haemostasis 88, no 11 (2002) : 843–50. http://dx.doi.org/10.1055/s-0037-1613312.

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SummaryThe F11 receptor (F11R) is a cell adhesion molecule (CAM), member of the immunoglobulin superfamily found on the surface of human platelets, and determined to play a role in platelet aggregation, secretion, adhesion and spreading. The same molecule is present also at tight junctions of endothelial cells (EC) where it is known as JAM and acts as a CAM through homophilic interactions. The role of F11R/JAM in the interaction of platelets with endothelial cells was investigated in the current studies. We report here that washed human platelets adhere specifically to a matrix made of immobilized, recombinant sF11R. Furthermore, platelets adhere to cytokine(TNF-α, INF-γ) stimulated human umbilical vein endothelial cells (HUVEC), and approximately 40-60% of the adhesive force is exerted by homophilic interactions between the F11R of platelets and EC. This is evidenced by the inhibition of platelet adhesion to endothelial cells by recombinant soluble form of the F11R, and by two F11R peptides with amino acid sequences of the N-terminal region, and in the 1st Ig fold of the F11R, respectively. This study suggests a role for F11R in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes. Agents that block the F11R-mediated adhesion of platelets to EC may be of therapeutic value in controlling thrombosis and preventing heart attacks and stroke.
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Sobocka, Malgorzata B., Tomasz Sobocki, Probal Banerjee, Cipora Weiss, Julie I. Rushbrook, Allen J. Norin, John Hartwig et al. « Cloning of the human platelet F11 receptor : a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation ». Blood 95, no 8 (15 avril 2000) : 2600–2609. http://dx.doi.org/10.1182/blood.v95.8.2600.

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Abstract This study demonstrates that the human platelet F11 receptor (F11R) functions as an adhesion molecule, and this finding is confirmed by the structure of the protein as revealed by molecular cloning. The F11R is a 32-/35-kd protein duplex that serves as the binding site through which a stimulatory monoclonal antibody causes platelet aggregation and granule secretion. A physiological role for the F11R protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the F11R was revealed by demonstrating the presence of F11R-antibodies in patients with thrombocytopenia. Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs). To determine the structure of this protein, we cloned the F11R cDNA from human platelets. The predicted amino acid sequence demonstrated that it is an integral membrane protein and an immunoglobulin superfamily member containing 2 extracellular C2-type domains. The structure of the F11R as a member of a CAM family of proteins and its activity in mediating adhesion confirm each another. We conclude that the F11R is a platelet-membrane protein involved in 2 distinct processes initiated on the platelet surface. The first is antibody-induced platelet aggregation and secretion that are dependent on both the FcγRII and the GPIIb/IIIa integrin and that may be involved in pathophysiological processes associated with certain thrombocytopenias. The second is an F11R-mediated platelet adhesion that is not dependent on either the FcγRII or the fibrinogen receptor and that appears to play a role in physiological processes associated with platelet adhesion and aggregation.
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Sobocka, Malgorzata B., Tomasz Sobocki, Probal Banerjee, Cipora Weiss, Julie I. Rushbrook, Allen J. Norin, John Hartwig et al. « Cloning of the human platelet F11 receptor : a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation ». Blood 95, no 8 (15 avril 2000) : 2600–2609. http://dx.doi.org/10.1182/blood.v95.8.2600.008k28_2600_2609.

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This study demonstrates that the human platelet F11 receptor (F11R) functions as an adhesion molecule, and this finding is confirmed by the structure of the protein as revealed by molecular cloning. The F11R is a 32-/35-kd protein duplex that serves as the binding site through which a stimulatory monoclonal antibody causes platelet aggregation and granule secretion. A physiological role for the F11R protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the F11R was revealed by demonstrating the presence of F11R-antibodies in patients with thrombocytopenia. Adhesion of platelets through the F11R resulted in events characteristic of the action of cell adhesion molecules (CAMs). To determine the structure of this protein, we cloned the F11R cDNA from human platelets. The predicted amino acid sequence demonstrated that it is an integral membrane protein and an immunoglobulin superfamily member containing 2 extracellular C2-type domains. The structure of the F11R as a member of a CAM family of proteins and its activity in mediating adhesion confirm each another. We conclude that the F11R is a platelet-membrane protein involved in 2 distinct processes initiated on the platelet surface. The first is antibody-induced platelet aggregation and secretion that are dependent on both the FcγRII and the GPIIb/IIIa integrin and that may be involved in pathophysiological processes associated with certain thrombocytopenias. The second is an F11R-mediated platelet adhesion that is not dependent on either the FcγRII or the fibrinogen receptor and that appears to play a role in physiological processes associated with platelet adhesion and aggregation.
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Babinska, Anna, Mamdouh Kedees, Humra Athar, Tomasz Sobocki, Malgorzata Sobocka, Tahir Ahmed, Yigal Ehrlich, M. Hussain et Elizabeth Kornecki. « Two Regions of the Human Platelet F11-Receptor (F11R) Are Critical for Platelet Aggregation, Potentiation and Adhesion ». Thrombosis and Haemostasis 87, no 04 (2002) : 712–21. http://dx.doi.org/10.1055/s-0037-1613070.

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SummaryThe F11 receptor (F11R) was first identified on the surface of human platelets as a target for a stimulatory monoclonal antibody (M.Ab.F11) that induces secretion, followed by exposure of fibrinogen receptors and aggregation. Cloning of the gene of F11R has revealed that this protein is a cell adhesion molecule (CAM), a member of the Ig superfamily and an ortholog of the murine protein called junctional adhesion molecule (JAM). The present study has identified two domains through which M.Ab.F11 triggers a platelet response culminating with aggregation. M.Ab.F11-mediated platelet adhesion, and the potentiation of collagen and ADP-induced platelet aggregation by M.Ab.F11, were found to involve the same two domains. A F11R recombinant protein (sF11R) completely inhibited platelet aggregation, adhesion and potentiation induced by M.Ab.F11, indicative that the active conformation of the external domain of F11R is present in the soluble, secreted recombinant protein. Furthermore, a specific peptide containing the sequence of the N-terminal amino acids S-1 to C-23 of F11R, and a peptide with the sequence of K-70 to C-82 in the 1st immunoglobulin-like (Ig) fold of F11R, both inhibited M.Ab.F11-induced aggregation, adhesion and potentiation of the aggregation of human platelets. Modeling of the 3D structure of the extracellular domain of the human platelet F11R suggests that these two regions form an active site within the conformation of this CAM. The sequence of these functional domains of F11R (in the N-terminus and 1st Ig-fold) provide the basis for new drug development in the treatment of certain types of thrombocytopenia and inflammatory thrombosis.
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Chagas, Edvan Alves, Jairo Osvaldo Cazetta, Eliana Gertrudes Macedo Lemos, Moacir Pasqual, Antonio de Goes, Jose Darlan Ramos, Rafael Pio, Wilson Barbosa, Vander Mendonça et Luis Alberto Ambrosio. « Identificação de híbridos de citros resistentes à mancha-marrom-de-alternária por meio de fAFLP e testes de patogenicidade ». Pesquisa Agropecuária Brasileira 42, no 7 (juillet 2007) : 975–83. http://dx.doi.org/10.1590/s0100-204x2007000700009.

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O objetivo deste trabalho foi identificar híbridos, oriundos de hibridações controladas entre 'Folha Murcha' x 'Ponkan' e testá-los quanto à resistência a Alternaria alternata f. sp. citri. As plântulas foram obtidas via cultura in vitro de embriões. Utilizou-se o marcador molecular fAFLP para identificação dos híbridos e, em seguida, realizou-se o teste de patogenicidade nos híbridos com isolados de Alternaria alternata f. sp. citri, em condições de laboratório. Os pares de primers EcoRI AAG - MseI CAG e EcoRI ACC - MseI CAA foram os mais eficientes na identificação dos híbridos, os quais identificaram 48,5% de híbridos. Os híbridos F64, F108, F111, F113, F131 e F139 são potencialmente resistentes a Alternaria alternata f. sp. citri.
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Thèses sur le sujet "F11A"

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Vermeersch, Sabine Anne. « Investigation of the F117A vortical flow characteristics ». Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/49908.

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Haddemo, Peter, et Jenny Siljehög. « Viktreducering av hydraulmaskin F11-010 ». Thesis, Högskolan Väst, Institutionen för ingenjörsvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-2997.

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Möjligheter att reducera vikten på en hydraulmotor, som tillverkas på Parker Hannifin AB i Trollhättan, har studerats. Målet med arbetet var att ge förslag på hur motorn kan göras lättare för att nå det framtida målet att erbjuda kunder en lättviktsmotor (LWM) lämpad som fläktmotor. För att identifiera komponenterna och deras vikter vägdes alla delar var för sig. Värdena visade att trumhus, lagerhus, axel och lagerpaket stod för ca 75 % av motorns totala vikt. Arbetet koncentrerades därför på att reducera vikten på dessa delar. Flera koncept togs fram med lägre vikt och bibehållen prestanda. Vissa delar kontrollerades mot hållfasthet med handberäkningar och FEM-analyser. Enligt beräkningarna finns möjlighet att reducera vikten med 45 %. Om hydraulmotorn konstrueras enligt koncepten, bör det framtida målet kunna nås, till-verkning av en lättviktsmotor som är betydligt lättare än dagens hydraulmotor.
The weight reducing possibilities for a hydraulic motor, produced by Parker Hannifin AB in Trollhättan, have been investigated. The goal was to provide suggestions for weight optimization to offer customers a light weight motor (LWM) that is well suited as a fan motor. The mass of each part was determined and their functions were identified. The result showed that the housings, shaft and bearings represented 75% of the motor’s total mass. The work was thus concentrated to these parts. Multiple suggestions were generated where weight and performance were taken into consideration. Some parts were analyzed with the aid of FEA-software and hand calculations. The result indicates that a weight reduction of 45% is possible. If the hydraulic motor is redesigned according to the concepts, the goal of a light weight motor can be achieved.
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Ma, Wenwei. « Protein-nanoparticles interaction and assembly ». Thesis, University of Lincoln, 2017. http://eprints.lincoln.ac.uk/30884/.

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Nanoparticles are increasingly important in biotechnology as they are extensively used as drug delivery carriers and in biosensors. In both these two contexts, protein-nanoparticle interactions are often involved. Proteins that are present in body fluids inevitably interact with nanoparticle based drug carriers and typically surround them forming the so called “protein corona”. Biosensors that are based on nanoparticles often have proteins deliberately attached to their surface, for example antibodies that bind specific analytes. The understanding of the assembly mechanisms at the protein-nanoparticle interface and the ability to engineer proteins that interact with nanoparticles in the desired way, are therefore two essential requisites for the future development of nano-medicines and nano-biosensors. In this work, we focused on the interaction of proteins with gold nanoparticles (GNPs). GNPs are available with a broad range of surface chemistries, suitable for the conjugation of many biomolecules. Although there are at least three decades of studies on gold colloids with different surface chemistries, there is still quite little known about what are the exact features of a protein that determine its adsorption onto gold. We developed methods to study this and applied them to characterise the adsorption on GNPs of Glutathione-S-Transerase (GST), which was reported previously as a protein that strongly binds gold. We determined its affinity and kinetics of binding and unravelled the mechanism of its thiol-mediated chemisorption. We found that GST binds to GNPs even more efficiently than other known gold-binding proteins, such as Bovine Serum Albumin (BSA). We concluded that GST could be considered a very useful gold-protein interface, especially considering that GST fusion is routinely used for affinity purification of recombinant proteins and therefore well established. We also fused self-assembling proteins to GST or chemically cross-linked them to BSA. The scope was to explore the feasibility of hierarchical and ordered assembly of designer proteins onto GNPs, with the ultimate goal of providing a convenient tool for modular assembly of proteins onto nanomaterials. It is known that proteins tend to denature and lose their function when in contact with GNPs, which is not optimal for biosensors or in nanomedicine. We found that it is possible to use GST or BSA to form a sacrificial layer on gold, which exposes linked, self-assembling proteins that are able to bind their counterpart, unaffected by the GNP surface. We reported two proof-of-concepts: the first based on mimics of the self-assembling neuronal SNARE proteins and the second based on the pair SpyCatcher/SpyTag, derived from Streptococcus pyogenes proteins and used in bio-conjugation for their ability to self-catalyse the formation of isopeptidic bonds. We believe that the novel methods and original results presented in this thesis apply to both the understanding and the engineering of the protein-nanoparticle interface and will be beneficial for the broad nanobiotechnology community. In fact, our findings have potential applications in a broad range of fields, spanning from the improvement of the circulation life-time of nanomedicines by preventing the binding of serum protein and opsonisation, to the improvement of the manufacturing of GNPs-based immune-biosensors such as those used in lateral flow devices.
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Karatasios, Ioannis. « The effect of barium hydroxide on the physicochemical properties of lime-based conservation mortars ». Thesis, De Montfort University, 2005. http://hdl.handle.net/2086/13255.

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The research undertaken concerns the analysis of original Byzantine mortars and the study of new compatible lime-based mixtures, for conservation purposes, which present enhanced resistance to sulphates. The thesis focuses on the effect of barium hydroxide, as an additive, to both the physicochemical properties and the durability of conservation mortars. Both binary pastes and mortar mixtures, containing varying amounts of barium hydroxide, were prepared and their physicochemical properties and durability determined. Comparisons were made with a reference mixture containing no barium hydroxide. The laboratory mixtures were synthesised according to the analysis of original mortars, collected from six different Byzantine mosaic pavements. The durability of the mortar mixtures against sulphate action was studied through the use of accelerated aging tests: crystallisation of soluble salts; electrochemical degradation; sulphate fixation; and resistance to leaching of cementing material. The results of these tests were considered together with the physical properties of the mortars, since these also influence their durability. From the interpretation of the results it was shown that the setting of lime-based barium mixtures can be described by two mechanisms; the carbonation process of calcium hydroxide and barium hydroxide; and the precipitation of a barium calcium carbonate [BaCa(CO3)2] solid solution. It has been shown that the presence of barium hydroxide in lime-based mortars has a physical effect on the pore space characteristics of the mortar. It has also been shown that its presence improves the durability of the mortar, playing a protective role against sulphate attack.
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Edwards, Stephen John. « Measurement of halides in photographic emulsions ». Thesis, University of Bedfordshire, 2003. http://hdl.handle.net/10547/622158.

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Conventional Ag/AgX electrodes, responsive to halide X, cannot be used to monitor the addition of a second halide Y since such additions result in a slow chemical conversion of the macroscopic halide coating AgX to AgY. This is a serious problem in the manufacture of photographic emulsions that frequently contain more than one silver halide. The thesis describes a new electrochemical measurement technique with the ability to make appropriate determinations in solutions of mixed halides. In the new technique (termed "clean/coat/measure"), silver electrodes were prepared "in situ" by applying square wave pulses to the electrode. First the previous halide layer was removed, then the electrode was coated in situ with a new layer of silver halide and this was used to measure the open circuit potential before the cycle was repeated. In this way the halide coating reflected the composition of the measurement solution. Existing commercial instrumentation was inappropriate for the proposed measurement sequence. Thus, a range of instrument hardware and software was designed and built by the author and used to study the influences of a multitude of parameters on the measurement performance. 1. A stable and accurate measurement system was designed and fabricated allowing the potentials of eight electrodes to be measured simultaneously in grounded solutions. Data was collected and stored on a PC using custom written software. Calibration curves for conventional silver/silver chloride, bromide and iodide electrodes were obtained over a range of concentrations and temperatures. Silver/silver halides electrodes with small surface areas (< 9 mm2) and thin halide coatings (< 1 nm thick) were studied to ensure that such electrodes performed as conventional large, thickly coated electrodes. Calibration curves showed no deterioration of response due to small surface areas and, over short time scales (< 2 min), no deterioration due to thin layers. 2. A laboratory instrument was designed and built to apply potential pulses, control a rotating disc electrode (RDE) and collect data. The system allowed both controlled potential pulses to be applied to the electrodes and open circuit potentiometric measurements to be made. Measurements of potential and current were collected at a rate of 10,000 measurements per second. The system used custom software running on a PC to control the instrumentation and to store data on the PC. Using this instrumentation a RDE was used to study the new "clean/coat/measure" pulsed technique. Results from the RDE study indicated that an electrode capable of sensing halide could be produced by this technique if an applied potential pulse with sufficient charge was applied. This minimum charge (11 x w-s C cm-2) produced a coating thickness approximately equivalent to a monolayer. The study also indicated that the technique was independent of the speed of rotation of the silver electrode and was successful over a wide range of conditions of pulse time, applied potential and cycle times for solution of potassium bromide in the range 0.001 to 0.05 M. The technique also successfully measured the addition of potassium iodide to a solution of potassium bromide while conventional thickly coated electrodes did not. 3. Two further instrumentation systems were designed and built to be used in a grounded stainless steel emulsion making vessel , one to apply controlled potential pulses and one to apply constant current pulses. Using these instruments and the conditions found for the RDE, static cylindrical electrodes in stirred solutions were investigated using both controlled potential and constant current square wave pulses of between 50 and 500 ms. Both potential step and current step techniques successfully measured the halide concentration of solutions of potassium chloride and bromide (0.001 to 0.5 M) and potassium iodide (0.0001 to 0.5 M). Both methods were also shown to be able to successfully monitor the addition of iodide to bromide and chloride solutions. With respect to future work, modifications to the instrumentation are proposed, including the replacement of the PC by an on-board microprocessor, the design of a multi-channel system and use of intelligent software to determine the optimum potential or current to apply. Areas of work required to be carried out before the system could be used in a production environment are given.
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Silvester, Debbie Sue. « Electrochemical studies in room temperature ionic liquids ». Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:be9e6269-f19a-48de-96e3-41c0c7143d6a.

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The work presented in this thesis involves the application of room temperature ionic liquids (RTILs) as solvents for use in electrochemical experiments. Initially, the fundamentals of electrochemistry is presented, followed by a comprehensive overview of RTILs in terms of their properties, applications and their behaviour as electrochemical solvents compared to conventional aprotic solvents. The results of 8 original studies are then presented as follows: X-Ray photoelectron spectroscopy is used to quantify the concentration of bromide ions in an ionic liquid, and is independently confirmed by potential-step chronoamperometry. The reaction mechanisms and kinetics for the electrochemical reduction of some aromatic nitro compounds (namely nitrobenzene and 4-nitrophenol) are determined. The electrochemistry of phosphorus trichloride and phosphorus oxychloride is studied in detail for the first time, due to the unusual stability of these highly reactive compounds in RTILs. The reductions and oxidations of sodium and potassium nitrate are studied, giving rise to 'melt'-like behaviour. The electrodeposition of sodium oxide on platinum is also demonstrated. The electrochemical oxidation of nitrite and the oxidation and reduction of the toxic gas, nitrogen dioxide, is presented. The oxidation of hydrogen gas is studied in ten RTILs with a range of different cations and anions, and contrasting interactions with the RTIL anions are seen. The electrochemical oxidation of ammonia gas is studied in five RTILs with different anions and a general reaction mechanism is suggested. The reduction of benzoic acid is studied in six RTILs, and the kinetics of the dissociation step are found to be very fast. The first five studies are all carried out in one particular ionic liquid, and the reactions and mechanisms are compared to that observed in conventional aprotic solvents. The last three studies employ several RTILs with different cations and anions to look at the contrasting interaction of protons with the RTIL cation/anion and ultimately help to understand the pH properties of the solvent. The overall findings from the work in this thesis are that some reactions and mechanisms (e.g bromide, nitro derivatives and ammonia) are generally the same in RTILs as in conventional aprotic solvents, but other species (e.g. nitrates, phosphorus derivatives) show remarkably different behaviour. It has also been demonstrated that RTILs are suitable media for the detection of nitrogen dioxide, hydrogen and ammonia gases. This suggests that RTILs could potentially offer many advantages when employed as solvents in electrochemical reactions and in amperometric gas sensors.
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Markwica, Robin. « The passions of power politics : how emotions influence coercive diplomacy ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f0c5b87d-f11c-4c61-bd8a-35feb7b56078.

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In coercive diplomacy, actors employ the threat of force to get targets to change their behavior. The goal is to achieve the opponent's compliance without waging war. In practice, however, the strategy often falls short-even when coercers enjoy substantial military superiority. This finding inspires the central question of this thesis: What prompts leaders to reject coercive threats from stronger adversaries, and under what conditions do they yield? I argue that target leaders' affective reactions can help to explain why coercive diplomacy succeeds in some cases but not in others. Combining insights from psychology and social constructivism, this thesis presents a theory of emotional choice to analyze how affect enters into target leaders' decision-making. Specifically, it makes the case that preferences are not only socially but also emotionally constructed. The core of the theoretical framework outlines how five key emotions-fear, anger, hope, pride, and humiliation-help to constitute target leaders' preferences. This represents the first attempt to explore how a spectrum of emotions influences leaders' foreign policy decision-making. To test the analytic utility of emotional choice theory, the thesis examines nine major decisions by Nikita Khrushchev during the Cuban missile crisis in 1962 and ten main decisions by Saddam Hussein in the course of the Gulf conflict in 1990-91. The analysis yields mixed results: In the case of about a third of all decisions, the five key emotions exerted only minor effects or no impact at all. Another third of the decisions were influenced by one or more of these emotions to a degree similar to the impact of other factors. In the case of the final third of decisions, however, some of these emotions became the primary forces shaping the construction of preferences. Overall, emotional choice theory has thus advanced our understanding of the target leaders' decision-making in the missile crisis and the Gulf conflict, offering a more comprehensive explanation of why coercive diplomacy succeeded in one case but not in the other.
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Dalung, Emma, et Mikael Johansson. « Kvalitetssäkring av monteringsmoment vid Fasta Motorers F11-montering utifrån en process-, felläges- och effektanalys ». Thesis, Högskolan Väst, Institutionen för ingenjörsvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-4257.

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I detta examensarbete har möjligheten att kvalitetssäkra en monteringsbana vid Parker Hannifin Manufacturing Sweden AB:s anläggning i Trollhättan utretts. Syftet med studien var att förbättra kvalitetssäkringen vid Fasta Motorers F11-montering och arbetet baserades på en tidigare utarbetad felläges- och effektanalys. För att styrka kundperspektivet genomfördes en undersökning av vad kunderna reklamerar, i form av PQP-anmälningar samt NCMR-rapporter. Genom att därefter identifiera kritiska monteringsmoment i felläges- och effektanalysen, PQP-anmälningar och NCMR-rapporter, var en prioritering möjlig att utföra. Prioriteringen resulterade i att feltyperna felvridet lagerhus, felplock av material samt kuggfel ansågs vara de mest kritiska att kvalitetssäkra. Målet med arbetet var att reducera det totala risktalsvärdet, vilket var möjligt genom en konceptgenerering samt ett konceptval för de specifika prioriteringarna. I samband med konceptgenereringen undersöktes, genom intervjuer med berörd personal, specifika kundbehov. Dessa kundbehov omarbetades därefter till målspecifikationer för att underlätta genereringen av koncept. Då informativa koncept var framtagna återstod ett val av det bäst lämpade konceptet. Valet utfördes med två olika metoder, screening och scoring samt 3P, för att ytterligare säkerställa att rätt koncept valts. Det var därmed möjligt att uppdatera felläges- och effektanalysen med de valda åtgärderna och då påvisa att syftet var uppnått. Syftet med kvalitetssäkringen uppnåddes genom att sänka det totala risktalsvärdet med 47,5 procent mot det tidigare risktalsvärdet, 6415.
In this thesis an investigation has been made in order to find possibilities to assure the quality at an assembly line at Parker Hannifin Manufacturing Sweden AB:s facility in Trollhättan. The purpose with the study was to improve the quality assurance at Fixed Motors F11-assembly line, where the work was based on an already conducted process-FMEA. In order to verify and further investigate the customer perspective, an inquiry was also done to see what customers complained about, this with help of PQP, Product Quality Problems, and NCMR, Nonconformance reports. By analyzing the process-FMEA, PQP and NCMR reports an identification and prioritization of critical failures were made. The result from these steps was three failures, incorrect positioning of the bearing house, picking of incorrect material and incorrect gear timing. These three were considered to be the most critical failures to quality assure. The aim with the quality work were set to reduce the total RPN, Risk Priority Number, of the process-FMEA, which was rendered by applying a concept generation and a concept selection for the specific failures. In relation with the concept selection, interviews were made with staff that was considered important and vital for the project. This was made to identify specific customer needs regarding solutions to the three failures. From these needs a target specification was developed to ease the generation of concepts. After generating a number of well specified concepts, a concept selection was made using the two methods screening and scoring and an additional Parker method called 3P to further establish that the right concepts was chosen. Further it was then possible to update the process-FMEA with the chosen concept solutions and by doing that reaching the project aim. By implementing the solutions it was possible to reduce total RPN, 6415, with 47,5 percent.
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Jovanovic, Milan. « Structure-function relationships in the protein subunit of bacterial ribonuclease P ». Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092422670.

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Thesis (Ph. D.)--Ohio State University, 2004.
Title from first page of PDF file. Document formatted into pages; contains xvii, 287 p.; also includes graphics (some col.). Includes bibliographical references (p. 282-287). Available online via OhioLINK's ETD Center
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Griffin, Sean James. « A systems engineering design of a retirement for cause life management process for life-limited F110-GE-400 engine parts ». Master's thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-03172010-020231/.

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Livres sur le sujet "F11A"

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F117, ili, Sunovrat NATO strategije. Beograd : Verzal press, 1999.

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The F-117A Stealth Fighter. Blue Ridge Summit, PA : TAB Aero, 1992.

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J, Ouzts Peter, et United States. National Aeronautics and Space Administration., dir. Real-time simulation of an F110/STOVL turbofan engine. [Washington, D.C.] : NASA, 1989.

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Drummond, Colin K. Real-time simulation of an F110/STOVL turbofan engine. [Washington, D.C.] : NASA, 1989.

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5

A, Clague D., et Geological Survey (U.S.), dir. Shipboard report for Hawaii GLORIA ground-truth cruise F11-88-HW, 25 Oct.-7 Nov., 1988. [Denver, Colo.?] : U.S. Dept. of the Interior, Geological Survey, 1989.

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Camm, Frank A. The development of the F100-PW-220 and F110-GE-100 engines : A case study of risk assessment and risk management. Santa Monica, CA (P.O. Box 2138, Santa Monica 90407-2138) : Rand, 1993.

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R, Hein James, et Geological Survey (U.S.), dir. Geology, geophysics, geochemistry, and deep-sea mineral deposits, Federated States of Micronesia : KORDI-USGS R.V. Farnella Cruise F11-90-CP. Menlo Park, CA : U.S. Geological Survey, 1992.

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Dodd, Luke. F11 Journal. Cork University Press, 2000.

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MARKETING 650 (F11 CUSTOM). McGraw Hill Learning Solutions, 2012.

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Ginter, Steve, Corwin Meyer et Ginter Steve. Naval Fighters Number Forty Grumman F11F Tiger. Naval Fighters, 1997.

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Chapitres de livres sur le sujet "F11A"

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Weik, Martin H. « dBa(F1A) ». Dans Computer Science and Communications Dictionary, 364. Boston, MA : Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_4427.

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Said, Hanan, et Robert Carachi. « F11 Ovarian Surgery ». Dans Basic Techniques in Pediatric Surgery, 407–9. Berlin, Heidelberg : Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-20641-2_124.

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Weik, Martin H. « F1A line weighting ». Dans Computer Science and Communications Dictionary, 668. Boston, MA : Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_7849.

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Behnert, Christiane. « Schlussbetrachtungen ». Dans Popularität und Relevanz in der Suche, 229–40. Wiesbaden : Springer Fachmedien Wiesbaden, 2022. http://dx.doi.org/10.1007/978-3-658-37512-6_5.

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ZusammenfassungDie Erforschung von Kriterien, anhand derer informationssuchende Personen die Relevanz von Dokumenten bewerten, ist Gegenstand vieler – hauptsächlich explorativer – informationswissenschaftlicher Studien. In den bisherigen Studien werden unterschiedliche Begriffe als Einflussparameter auf die Relevanzbewertung verwendet, die keiner einheitlichen Definition folgen und sich auch konzeptuell nicht eindeutig voneinander abgrenzen lassen. Diese Forschungslücke wurde im Rahmen der vorliegenden Arbeit mit der Beantwortung der Forschungsfrage F1a (Wie lassen sich Merkmale, Kriterien und Faktoren als Einflüsse im Prozess der Relevanzbewertung für die Entwicklung eines experimentellen Untersuchungsdesigns definitorisch und konzeptuell voneinander abgrenzen?) und mit der in direktem Zusammenhang stehenden Forschungsfrage F1b (Wie können Kriterien bei der Relevanzbewertung von Suchergebnissen für eine experimentelle Studie operationalisiert werden?) geschlossen.
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Miller, S. A., D. D. Dykes et M. S. Schanfield. « Identification of F13A*7 as a Population Specific Marker ». Dans Advances in Forensic Haemogenetics, 296–99. Berlin, Heidelberg : Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75496-8_88.

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Riola, J. M., J. C. Díaz-Cuadra et Publio Beltrán. « Noise and Vibration Control Program for Warship : The New Spanish Frigate F110 ». Dans Proceeding of the VI International Ship Design & ; Naval Engineering Congress (CIDIN) and XXVI Pan-American Congress of Naval Engineering, Maritime Transportation and Port Engineering (COPINAVAL), 163–74. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-35963-8_14.

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Dykes, Dale D., Shirley Miller et Herbert Polesky. « Gene Frequency Distribution of F13A and F13B in U.S. Whites, Blacks, Amerindians and Mexican-Americans ». Dans Advances in Forensic Haemogenetics, 261–67. Berlin, Heidelberg : Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71150-3_56.

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Yu, Yong-gang, Jing Yu, Zhu Zhou, Jiangtao Huang, Gang Liu et Xiong Jiang. « Numerical Simulation for DLR-F11 Based on PMB3D Solver with Structural Overlapped Grid ». Dans Lecture Notes in Electrical Engineering, 711–22. Singapore : Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-3305-7_57.

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Delany, I. R., U. F. Walsh, I. Ross, A. M. Fenton, D. M. Corkery et F. O’Gara. « Enhancing the biocontrol efficacy of Pseudomonas fluorescens F113 by altering the regulation and production of 2,4-diacetylphloroglucinol ». Dans Interactions in the Root Environment : An Integrated Approach, 195–205. Dordrecht : Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0566-1_19.

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Caesar], Caesar [Gaius Julius. « Grammatical Number (F11A–B) ». Dans Caesar's De Analogia, sous la direction de Alessandro Garcea, 187. Oxford University Press, 2012. http://dx.doi.org/10.1093/oseo/instance.00168532.

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Actes de conférences sur le sujet "F11A"

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TADIOS, EDEN. « F111 crew escape module pilot parachute ». Dans 11th Aerodynamic Decelerator Systems Technology Conference. Reston, Virigina : American Institute of Aeronautics and Astronautics, 1991. http://dx.doi.org/10.2514/6.1991-883.

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Castells, O. T., et J. T. Strong. « F-14 Re-Engining With the F110 Engine ». Dans ASME 1985 International Gas Turbine Conference and Exhibit. American Society of Mechanical Engineers, 1985. http://dx.doi.org/10.1115/85-gt-184.

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The advantages of re-engining the F-14 aircraft with the F110 engine is presented. The areas of improvement and the engine development philosophy are explained. A summary description of the pertinent engine design features of the F110 are presented. The flight test results on inlet/engine compatability, afterburner operation, airplane performance, and maintainability/reliability/durability are interpreted. Finally, a description of the proposed version of the F110 engine for the F-14 is presented.
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Khamis, Mostafa. « F1A : Networks on chip ». Dans 2017 30th IEEE International System-on-Chip Conference (SOCC). IEEE, 2017. http://dx.doi.org/10.1109/socc.2017.8226063.

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Collberg, Leif, Malcolm Carr et Erik Levold. « Safebuck Design Guideline and DNV-RP-F110 ». Dans Offshore Technology Conference. Offshore Technology Conference, 2011. http://dx.doi.org/10.4043/21575-ms.

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Wadia, A. R., et F. D. James. « F110-GE-129 EFE — Enhanced Power Through Low Risk Derivative Technology ». Dans ASME Turbo Expo 2000 : Power for Land, Sea, and Air. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/2000-gt-0578.

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The F110-GE-129 EFE (Enhanced Fighter Engine), presently undergoing qualification testing, is being offered at two different thrust/inspection levels with a maximum augmented thrust of 34,000 pounds. The EFE has been developed using low risk derivative engine technology. It features a new increased airflow, high efficiency, three-stage long chord blisk fan and an advanced radial augmentor that reduces complexity, improves maintainability and provides increased parts life. The paper first provides a historical background of the F110 engines to relate the heritage of the F110-GE-129 EFE. The F110 engine model development roadmap is shown to illustrate the incremental low risk approach used to provide thrust growth with improved product reliability. A detailed description of the unique power management features of the EFE engine to meet individual customer thrust and life requirements is outlined. The long chord blisk fan design, development and test results are presented followed by a description of the radial augmentor and the exhaust nozzle. The EFE engine has successfully completed sea level static and altitude development testing and fan aero mechanical qualification at the AEDC in Tullahoma, Tennessee.
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Green, Steven, et Dennis Fernandez. « F117A composite rudder aeroelastic stability flight test program ». Dans Biennial Flight Test Conference. Reston, Virigina : American Institute of Aeronautics and Astronautics, 1994. http://dx.doi.org/10.2514/6.1994-2107.

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« F1A : MPSoC and Design Methodologies I ». Dans 2018 31st IEEE International System-on-Chip Conference (SOCC). IEEE, 2018. http://dx.doi.org/10.1109/socc.2018.8618528.

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« F1A : MPSoC and Design Methodologies I ». Dans 2018 31st IEEE International System-on-Chip Conference (SOCC). IEEE, 2018. http://dx.doi.org/10.1109/socc.2018.8618547.

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Miner, J. R., J. Dell, A. T. Galbato et M. A. Ragen. « F117–PW–100 Hybrid Ball Bearing Ceramic Technology Insertion ». Dans ASME 1995 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1995. http://dx.doi.org/10.1115/95-gt-390.

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Results of an Advanced Research Projects Agency (ARPA) sponsored project to demonstrate the operational benefits of incorporating advanced structural ceramic ball elements into the F117–PW–100 aircraft gas turbine engine high rotor thrust bearings is described. This program consists of design, fabrication and experimental evaluation of candidate hybrid ball bearing designs in Pratt & Whitney and MRC Bearings test facilities. The bearing design criteria and development test conditions utilized for the project are compatible with the requirements of the F117–PW–100 engine system application. Two hybrid bearing designs were produced by analytically varying internal geometry features such as M–50 race curvatures and contact angles to optimize for the modulus of elasticity of the ceramic balls. One–and–one–eighth inch size CERBEC grade NBD 200 silicon nitride ceramic balls demonstrated integrity and a quadruple rolling contact fatigue life improvement versus state–of–the–art M–50 steel balls in single ball test rigs. Thermal performance data obtained in full scale bearing rig performance testing with one–hundred–seventy–eight millimeter size hybrid and all–steel baseline bearings shows comparable characteristics. The hybrid bearing displayed a distinct survivability benefit in bearing liquid lubricant starvation testing. Two dozen hybrid bearings will be fabricated for full–scale bearing rig endurance tests to be conducted in 1995–1996 as a prerequisite to validation in operating F117–PW–100 engines in 1996–1997.
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Haldorsen, Lars M., Bård Nyhus et Gisle Rørvik. « Hydrogen Induced Stress Cracking of Superduplex Steels : Effect of Operation Temperature ». Dans ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-77252.

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Duplex stainless steel has been used on subsea facilities since the mid 80-ties. The experiences with these materials have been relative good and only a few failures have been reported. However, BP and Shell experience some serious cracking of duplex steel in the mid 90-ties and in beginning of the century. The root cause of these failures was identified to be Hydrogen Induced Stress Cracking, HISC, where the hydrogen source was the cathodic protection system of the subsea facility. These and other similar failures resulted establishment of Joint Industry Projects, JIPs with financial and technical contribution from leading oil companies, contractors, material suppliers and research institutions as TWI, SINTEF and DNVGL. The objective of the JIPs was to establish practical usage limits for duplex stainless steels. The JIPs resulted in a recommended practice “DNV-RP-F112 - Design of duplex stainless subsea equipment exposed to cathodic protection.” This document minimized the failure rate of duplex steel components used subsea. However, since duplex steels components have been used on subsea facilities long before the guidelines and recommendations were issued, there are lot of components presently in use that may be overloaded compared to guidelines and recommendations. As a part of life time extension of one of Statoil’s long time producing fields, a HISC re-calculation of spools connecting SPSs to infield pipelines showed that many of the spools were exposed to stresses above the recommended stresses given in DNV-RP-F112. Since these recommendations were primarily based on testing at ambient seabed temperature (4°C), Statoil, together with SINTEF, started in 2016 a project where the aim was to evaluate the resistance against HISC as an effect of the operation temperature. The results of this project show that the critical net section stress/AYS (HISC resistance) increases with increasing temperature. Based on this, the before mentioned spools can be considered safe even though the spools are exposed to stresses above the recommendations in DNV-RP-F112. Further, the investigations show that the guidelines and recommendations given in DNV-RP-F112 may be conservative for temperatures above 4°C. It is therefore recommended to perform more testing to confirm and incorporate the findings from the present investigation in future revision of DNV-RP-F112.
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Rapports d'organisations sur le sujet "F11A"

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Ethington, P. R. Concentrator E-F11 water test. Office of Scientific and Technical Information (OSTI), février 1994. http://dx.doi.org/10.2172/10153902.

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Shumway, L. A. Characterization of Jet Engine Exhaust Particulates for the F404, F118, T64, and T58 Aircraft Engines. Fort Belvoir, VA : Defense Technical Information Center, mars 2002. http://dx.doi.org/10.21236/ada405470.

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DoD Office of Inspector General. U.S. Air Force Spent Billions on F117 Engine Sustainment Without Knowing What a Fair Price Was. Fort Belvoir, VA : Defense Technical Information Center, mars 2016. http://dx.doi.org/10.21236/ad1016478.

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Olaes, Christopher, Richard Lampo, Lawrence Clark, Susan Drozdz et Jeffrey Ryan. Demonstration and validation of portable electrochemical impedance spectroscopy technology : final report on Project F11-AR08. Construction Engineering Research Laboratory (U.S.), juin 2018. http://dx.doi.org/10.21079/11681/27349.

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McInerney, Michael, Steven Sweeney et Orange Marshall. Demonstration of dehumidification technology for a missile-storage facility : final report on Project F11-AR25. Engineer Research and Development Center (U.S.), mars 2019. http://dx.doi.org/10.21079/11681/32297.

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SCALE : A modular code system for performing standardized computer analyses for licensing evaluation : Functional modules, F9-F11. Office of Scientific and Technical Information (OSTI), mars 1997. http://dx.doi.org/10.2172/469123.

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