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Littérature scientifique sur le sujet « Ependymal stem progenitor cells »

Auteur : Grafiati

Publié le 9 mars 2023

Mis à jour le 10 mars 2023

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Articles de revues sur le sujet "Ependymal stem progenitor cells"

Xing, Liujing, Teni Anbarchian, Jonathan M. Tsai, Giles W. Plant et Roeland Nusse. « Wnt/β-catenin signaling regulates ependymal cell development and adult homeostasis ». Proceedings of the National Academy of Sciences 115, n^o 26 (11 juin 2018) : E5954—E5962. http://dx.doi.org/10.1073/pnas.1803297115.

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In the adult mouse spinal cord, the ependymal cell population that surrounds the central canal is thought to be a promising source of quiescent stem cells to treat spinal cord injury. Relatively little is known about the cellular origin of ependymal cells during spinal cord development, or the molecular mechanisms that regulate ependymal cells during adult homeostasis. Using genetic lineage tracing based on the Wnt target geneAxin2, we have characterized Wnt-responsive cells during spinal cord development. Our results revealed that Wnt-responsive progenitor cells are restricted to the dorsal midline throughout spinal cord development, which gives rise to dorsal ependymal cells in a spatially restricted pattern. This is contrary to previous reports that suggested an exclusively ventral origin of ependymal cells, suggesting that ependymal cells may retain positional identities in relation to their neural progenitors. Our results further demonstrated that in the postnatal and adult spinal cord, all ependymal cells express the Wnt/β-catenin signaling target geneAxin2, as well as Wnt ligands. Genetic elimination of β-catenin or inhibition of Wnt secretion in Axin2-expressing ependymal cells in vivo both resulted in impaired proliferation, indicating that Wnt/β-catenin signaling promotes ependymal cell proliferation. These results demonstrate the continued importance of Wnt/β-catenin signaling for both ependymal cell formation and regulation. By uncovering the molecular signals underlying the formation and regulation of spinal cord ependymal cells, our findings thus enable further targeting and manipulation of this promising source of quiescent stem cells for therapeutic interventions.

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Mothe, Andrea J., Iris Kulbatski, Rita L. van Bendegem, Linda Lee, Eiji Kobayashi, Armand Keating et Charles H. Tator. « Analysis of Green Fluorescent Protein Expression in Transgenic Rats for Tracking Transplanted Neural Stem/Progenitor Cells ». Journal of Histochemistry & ; Cytochemistry 53, n^o 10 (27 juin 2005) : 1215–26. http://dx.doi.org/10.1369/jhc.5a6639.2005.

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Green fluorescent protein (GFP) expression was evaluated in tissues of different transgenic rodents—Sprague-Dawley (SD) rat strain [SD-Tg(GFP)Bal], W rat strain [Wistar-TgN(CAG-GFP)184ys], and M mouse strain [Tg(GFPU)5Nagy/J]—by direct fluorescence of native GFP expression and by immunohistochemistry. The constitutively expressing GFP transgenic strains showed tissue-specific differences in GFP expression, and GFP immunohistochemistry amplified the fluorescent signal. The fluorescence of stem/progenitor cells cultured as neurospheres from the ependymal region of the adult spinal cord from the GFP SD and W rat strains was assessed in vitro. After transplantation of the cells into wildtype spinal cord, the ability to track the grafted cells was evaluated in vivo. Cultured stem/progenitor cells from the SD strain required GFP immunostaining to be visualized. Likewise, after transplantation of SD cells into the spinal cord, immunohistochemical amplification of the GFP signal was required for detection. In contrast, GFP expression of stem/progenitor cells generated from the W strain was readily detected by direct fluorescence both in vitro and in vivo without the need for immunohistochemical amplification. The cultured stem/progenitor cells transplanted into the spinal cord survived for at least 49 days after transplantation, and continued to express GFP, demonstrating stable expression of the GFP transgene in vivo.

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Rodriguez-Jimenez, Francisco, Ana Alastrue-Agudo, Miodrag Stojkovic, Slaven Erceg et Victoria Moreno-Manzano. « Connexin 50 Expression in Ependymal Stem Progenitor Cells after Spinal Cord Injury Activation ». International Journal of Molecular Sciences 16, n^o 11 (6 novembre 2015) : 26608–18. http://dx.doi.org/10.3390/ijms161125981.

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Rodriguez-Jimenez, Francisco Javier, Ana Alastrue, Miodrag Stojkovic, Slaven Erceg et Victoria Moreno-Manzano. « Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells ». Cell and Tissue Research 365, n^o 2 (24 mai 2016) : 295–307. http://dx.doi.org/10.1007/s00441-016-2421-y.

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Finkel, Zachary, Fatima Esteban, Brianna Rodriguez, Tianyue Fu, Xin Ai et Li Cai. « Diversity of Adult Neural Stem and Progenitor Cells in Physiology and Disease ». Cells 10, n^o 8 (10 août 2021) : 2045. http://dx.doi.org/10.3390/cells10082045.

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Adult neural stem and progenitor cells (NSPCs) contribute to learning, memory, maintenance of homeostasis, energy metabolism and many other essential processes. They are highly heterogeneous populations that require input from a regionally distinct microenvironment including a mix of neurons, oligodendrocytes, astrocytes, ependymal cells, NG2+ glia, vasculature, cerebrospinal fluid (CSF), and others. The diversity of NSPCs is present in all three major parts of the CNS, i.e., the brain, spinal cord, and retina. Intrinsic and extrinsic signals, e.g., neurotrophic and growth factors, master transcription factors, and mechanical properties of the extracellular matrix (ECM), collectively regulate activities and characteristics of NSPCs: quiescence/survival, proliferation, migration, differentiation, and integration. This review discusses the heterogeneous NSPC populations in the normal physiology and highlights their potentials and roles in injured/diseased states for regenerative medicine.

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Gotoh, Yukiko. « IL2 Neural stem cell regulation and brain development ». Neuro-Oncology Advances 3, Supplement_6 (1 décembre 2021) : vi1. http://dx.doi.org/10.1093/noajnl/vdab159.001.

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Abstract Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone (SVZ) are derived from a subpopulation of embryonic neural stem-progenitor cells (NPCs) that is characterized by a slower cell cycle relative to the more abundant rapid cycling NPCs that build the brain. We have previously shown that slow cell cycle can cause the establishment of adult NSCs at the SVZ, although the underlying mechanism remains unknown. We found that Notch and an effector Hey1 form a module that is upregulated by cell cycle arrest in slowly dividing NPCs. In contrast to the oscillatory expression of the Notch effectors Hes1 and Hes5 in fast cycling progenitors, Hey1 displays a non-oscillatory stationary expression pattern and contributes to the long-term maintenance of NSCs. These findings reveal a novel division of labor in Notch effectors where cell cycle rate biases effector selection and cell fate. I will also discuss the heterogeneity of slowly dividing embryonic NPCs and the lineage relationship between adult NSCs and ependymal cells, which together form the niche for adult neurogenesis at the SVZ.

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Donato, Sarah V., et Matthew K. Vickaryous. « Radial Glia and Neuronal-like Ependymal Cells Are Present within the Spinal Cord of the Trunk (Body) in the Leopard Gecko (Eublepharis macularius) ». Journal of Developmental Biology 10, n^o 2 (1 juin 2022) : 21. http://dx.doi.org/10.3390/jdb10020021.

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As is the case for many lizards, leopard geckos (Eublepharis macularius) can self-detach a portion of their tail to escape predation, and then regenerate a replacement complete with a spinal cord. Previous research has shown that endogenous populations of neural stem/progenitor cells (NSPCs) reside within the spinal cord of the original tail. In response to tail loss, these NSPCs are activated and contribute to regeneration. Here, we investigate whether similar populations of NSPCs are found within the spinal cord of the trunk (body). Using a long-duration 5-bromo-2′-deoxyuridine pulse-chase experiment, we determined that a population of cells within the ependymal layer are label-retaining following a 20-week chase. Tail loss does not significantly alter rates of ependymal cell proliferation within the trunk spinal cord. Ependymal cells of the trunk spinal cord express SOX2 and represent at least two distinct cell populations: radial glial-like (glial fibrillary acidic protein- and Vimentin-expressing) cells; and neuronal-like (HuCD-expressing) cells. Taken together, these data demonstrate that NSPCs of the trunk spinal cord closely resemble those of the tail and support the use of the tail spinal cord as a less invasive proxy for body spinal cord injury investigations.

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Marcuzzo, Stefania, Dimos Kapetis, Renato Mantegazza, Fulvio Baggi, Silvia Bonanno, Claudia Barzago, Paola Cavalcante, Nicole Kerlero de Rosbo et Pia Bernasconi. « Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells ». Experimental Neurology 253 (mars 2014) : 91–101. http://dx.doi.org/10.1016/j.expneurol.2013.12.007.

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Redmond, Stephanie A., María Figueres-Oñate, Kirsten Obernier, Marcos Assis Nascimento, Jose I. Parraguez, Laura López-Mascaraque, Luis C. Fuentealba et Arturo Alvarez-Buylla. « Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor ». Cell Reports 27, n^o 2 (avril 2019) : 429–41. http://dx.doi.org/10.1016/j.celrep.2019.01.088.

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Mokhtar, Doaa M., Ramy K. A. Sayed, Giacomo Zaccone, Marco Albano et Manal T. Hussein. « Ependymal and Neural Stem Cells of Adult Molly Fish (Poecilia sphenops, Valenciennes, 1846) Brain : Histomorphometry, Immunohistochemical, and Ultrastructural Studies ». Cells 11, n^o 17 (27 août 2022) : 2659. http://dx.doi.org/10.3390/cells11172659.

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This study was conducted on 16 adult specimens of molly fish (Poecilia sphenops) to investigate ependymal cells (ECs) and their role in neurogenesis using ultrastructural examination and immunohistochemistry. The ECs lined the ventral and lateral surfaces of the optic ventricle and their processes extended through the tectal laminae and ended at the surface of the tectum as a subpial end-foot. Two cell types of ECs were identified: cuboidal non-ciliated (5.68 ± 0.84/100 μm2) and columnar ciliated (EC3.22 ± 0.71/100 μm2). Immunohistochemical analysis revealed two types of GFAP immunoreactive cells: ECs and astrocytes. The ECs showed the expression of IL-1β, APG5, and Nfr2. Moreover, ECs showed immunostaining for myostatin, S100, and SOX9 in their cytoplasmic processes. The proliferative activity of the neighboring stem cells was also distinct. The most interesting finding in this study was the glia–neuron interaction, where the processes of ECs met the progenitor neuronal cells in the ependymal area of the ventricular wall. These cells showed bundles of intermediate filaments in their processes and basal poles and were connected by desmosomes, followed by gap junctions. Many membrane-bounded vesicles could be demonstrated on the surface of the ciliated ECs that contained neurosecretion. The abluminal and lateral cell surfaces of ECs showed pinocytotic activities with many coated vesicles, while their apical cytoplasm contained centrioles. The occurrence of stem cells in close position to the ECs, and the presence of bundles of generating axons in direct contact with these stem cells indicate the role of ECs in neurogenesis. The TEM results revealed the presence of neural stem cells in a close position to the ECs, in addition to the presence of bundles of generating axons in direct contact with these stem cells. The present study indicates the role of ECs in neurogenesis.

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Thèses sur le sujet "Ependymal stem progenitor cells"

MARCUZZO, STEFANIA. « New insights in the understanding of motor neuron disease by longitudinal brain and muscle MRI analysis and characterization of spinal cord-derived stem cells in G93-SOD1 mouse model of ALS ». Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/43854.

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Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative disorder caused by the degeneration of motor neurons in the CNS, which results in complete paralysis of skeletal muscles. To establish the timeframe of motor neuron degeneration in relation to muscle atrophy in motor neuron disease, we have used MRI to monitor changes throughout disease in brain and skeletal muscle of G93A-SOD1 mice, a purported model of ALS. Longitudinal MRI examination of the same animals indicated that muscle volume in the G93A-SOD1 mice was significantly reduced from as early as week 8 of life, four weeks prior to clinical onset. Progressive muscle atrophy from week 8 onwards was confirmed by histological analysis. In contrast, brain MRI indicated that neurodegeneration occurs later in G93A-SOD1 mice, with hyperintensity MRI signals detected only at weeks 10-18. Neurodegenerative changes were observed only in the motor nuclei areas of the brainstem; MRI changes indicative of neurodegeneration were not detected in the motorcortex where first motor neurons originate, even at the late disease stage. This longitudinal MRI study establishes unequivocally that, in the experimental murine model of ALS, muscle degeneration occurs before any evidence of neurodegeneration and clinical signs, supporting the postulate that motor neuron disease can initiate from muscle damage and result from retrograde dying-back of the motor neurons. In G93A-SOD1 ALS mice the response to neurodegeneration comprises proliferation and migration of ependymal stem progenitor cells (epSPCs), normally present and quiescent in spinal cord. We isolated epSPCs from G93A-SOD1 mice at 8 (asymptomatic) and 18 (symptomatic) weeks of age, and characterized the ability of epSPC cultures to proliferate and differentiate into the three neural cell lineages. G93A epSPCs produced neurospheres of self-renewing cells, and differentiated into more neurons and fewer astrocytes than control epSPCs, whereas oligodendrocytes did not show difference between the examined groups. The G93A-SOD1 neurons were small and the astrocytes were consistently activated. MicroRNA analysis revealed that miR-9 and miR-124a, involved in neural cell fate, were upregulated in differentiating G93A-SOD1 epSPCs, particularly at 18 weeks. miR-19a and miR-19b, implicated in cell-cycle regulation, were differentially expressed during epSPC differentiation in G93A-SOD1 compared with controls. Our findings demonstrated that G93A-SOD1 epSPCs have neurogenic potential constituting a source of multipotent cells useful for understanding the ALS pathogenesis and for identifying new therapeutic targets.

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Noisa, Parinya. « Characterization of neural progenitor/stem cells derived from human embryonic stem cells ». Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5712.

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Human embryonic stem cells (hESCs) are able to proliferate indefinitely without losing their ability to differentiate into multiple cell types of all three germ layers. Due to these fascinating properties, hESCs have promise as a robust cell source for regenerative medicine and as an in vitro model for the study of human development. In my PhD study, I have investigated the neural differentiation process of hESCs using our established protocol, identified characteristics associated with each stage of the differentiation and explored possible signalling pathways underlying these dynamic changes. It was found that neural differentiation of hESCs could be divided into 5 stages according to their morphology, marker expression and differentiation potencies: hESCs, neural initiation, neural epithelium/rosette, neuronal progenitor cells and neural progenitor/stem cells (NPSCs) and 4 of these stages have been studied in more detail. At the neural initiation, hESCs firstly lose TRA-1-81 expression but retain SSEA4 expression. This transient cell population shows several similar properties to the primitive ectoderm. After neural-tube like structure/neural rosette formation, neural progenitor cells appear as typical bipolar structures and exhibit several properties of radial glial cells, including gene expression and pro-neuronal differentiation. The neural progenitor cells are able to grow in culture for a long time in the presence of growth factors bFGF and EGF. However, they gradually lose their bipolar morphology to triangular cell type and become pro-glial upon further differentiation. In addition, the state of neural progenitor and stem cells can be distinguished by their differential response to canonical Notch effector, C protein-binding factor 1. It was also found that delta like1 homolog (DLK-1) is temporally upregulated upon initial neural differentiation, but becomes undetectable after the neural progenitor stage. Overexpression of DLK-1 in NPSCs enhances neuronal differentiation in the presence of serum by blocking BMP and Notch pathways. These results show that neural differentiation of hESCs is a dynamic process in which cells go through sequential changes, and the events are reminiscent of the in vivo neurodevelopment process. Moreover, I have characterized stably transfected nestin-GFP reporter hESC lines and found that the cell lines maintained the features of hESCs and the expression of GFP is restricted to the neural lineage after differentiation. Therefore, these reporter lines will be useful for the study of factors that regulate neural differentiation and for the enrichment of neural progenitors from other lineages. Taken together, this study has demonstrated that hESCs are a good in vitro model to study the mechanisms and pathways that are involved in neural differentiation. The availability of hESCs allows us to explore previously inaccessible processes that occur during human embryogenesis, such as gastrulation and neurogenesis.

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Marshall, Gregory Paul. « Neurospheres and multipotent astrocytic stem cells neural progenitor cells rather than neural stem cells / ». [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010047.

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Thesis (Ph.D.)--University of Florida, 2005.
Typescript. Title from title page of source document. Document formatted into pages; contains 97 pages. Includes Vita. Includes bibliographical references.

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Greenhowe, Jennifer. « Stem and progenitor cells in wound healing ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:87a9a7a1-b595-458a-913f-64497174f988.

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As more patients with large body surface area burns are surviving and requiring reconstructive surgery, there is a necessity for advances in the provision of bioengineered alternatives to autologous skin cover. The aims of this Thesis are to identify feasible source tissues of Endothelial Colony Forming Cells and Mesenchymal Stem/Stromal Cells for microvascular network formation in vitro with three-dimensional dermal substitute scaffolds. The working hypothesis is that pre-vascularised dermal scaffolds will result in better quality scarring when used with split thickness skin grafts. Human umbilical cord blood, peripheral blood and adipose tissue were collected and processed with ethical approval and informed consent. Samples were cultured to form endothelial outgrowth colonies and confluent Mesenchymal Stem/Stromal Cells, which were characterised using flow cytometry and expanded in vitro. Mesenchymal Stem/Stromal Cell multipotency was confirmed with tri-lineage mesenchymal differentiation. Primary cells were tested in a two-dimensional tubule formation co-culture assay and differences assessed using a proangiogenic antibody array. Tubule formation was tested in four different acellular dermal substitute scaffolds; Integra® Dermal Regeneration Template, Matriderm®, Neuskin-F® and De-cellularised Human Cadaveric Dermis. Umbilical cord blood was the most reliable source of Endothelial Colony Forming Cells, the yield of which could be predicted from placental weight. Microvasculature dissected free from adipose tissue was a reliable source of Mesenchymal Stem/Stromal Cells which supported significantly more tubule formation than Mesenchymal Stem/Stromal Cells from whole adipose tissue. Microvasculature Mesenchymal Stem/Stromal Cells secreted significantly higher levels of the proangiogenic hormone leptin, and addition of exogenous leptin to the tubule formation assay resulted in significantly increased tubule formation. Microvasculature was cultured in all four of the scaffolds tested, but depth of penetration was limited to 100µm. The artificial oxygen carrier perfluorocarbon was shown to increase two-dimensional tubule formation and may be useful in further three-dimensional scaffolds studies to improve microvascular penetration.

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Pearce, Daniel. « Intracellular analysis of stem and progenitor cells ». Thesis, Kingston University, 2001. http://eprints.kingston.ac.uk/20685/.

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A population of rare pluripotential stem cells with extensive proliferative and self-renewal capabilities sustains haemopoiesis throughout life. Such cells, capable of differentiating into any haemopoietic lineage are required for gene therapy, ex-vivo expansion and stem cell transplantation strategies. It is currently not possible to positively identify these cells; their presence can only be retrospectively assessed through elaborate, time consuming culture techniques and animal repopulating studies. Stem cells can be isolated through negative selection, a complex and very expensive procedure. The CD34 antigen is routinely used as a surrogate marker of primitive haemopoietic cells and identifies most of the committed progenitors of the bone marrow as well as some of the more immature pluripotential cells. AC133, discovered in 1997, is reportedly expressed on a subset of CD34[sup]+stem/progenitor cells, suggesting an alternative for CD34. The present study first assessed the potential of one or both molecules (CD34/AC133) for progenitor cell acquisition in order to determine the status of AC133 as a unique stem cell antigen. Results suggested that selection of cells on the basis of AC133 excluded the more mature committed cells of the CD34[sup]+ population (especially erythroid). Consequently, the AC133[sup]+ population is more highly enriched (than the whole CD34[sup]+ cell population) for cells of a high proliferative potential and long-term culture initiating ability. The CD34 molecule can be very quickly upregulated. Upregulation is rapid (1 minute), independent of transcription/translation, and is unaffected by inhibitors of protein synthesis. Upregulation is of a fully formed glycosylated molecule and is probably from preformed intracellular stores. This research developed methodology for simultaneously fluorescent antibody-labelling internal and external stores of CD34. This was applied to investigating the internal expression of CD34, attempting to determine its significance in the hierarchy of haemopoietic cells, and this was achieved via flow cytometry, simultaneously examining the expression of internal CD34, external CD34 and one other established haemopoietic cell marker (CD38, AC133, Thy-1, CD164, CD117 and CD7). The results indicated that the CD34 molecule translocates from internal stores to membrane surface during external CD34[sup]+ haemopoietic stem/progenitor cell maturation and development. In addition, internal CD34 expression identifies a novel subset of primitive haemopoietic external CD34 negative (CD34[sup]NEG) cells, which may contain cells that precede external CD34[sup]+ cells in the hierarchy of haemopoiesis. Specific fluorescent antibody labelling was then confirmed by laser confocal microscope examination of labelled cells. The technique of simultaneously labelling 2 antigens for the confocal microscope was established, and allowed the cellular localisation of internal and external CD34 to be confirmed. A possible clinical application of this technology (internal CD34 labelling) to the monitoring of mobilisation protocols was further investigated by analysing daily peripheral blood samples, taken from patients undergoing G-CSF mobilisation therapy. Results suggested that cells with a more primitive phenotype (internal CD34[sup]+, external CD34[sup]NEG) than external CD34[sup]+ cells are released in significant numbers during the early stages of mobilisation, and are missed by the conventional harvest date. Such cells may have an improved transplant potential. This Ph.D. project has established the significance of internal CD34 expression a possible application and has identified a possible application for this technology.

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Chavez, Garcia Edison. « Phosphoinositides regulation and function in the ciliary compartment of Neural stem cells and Ependymal cells ». Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/221625.

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This thesis describes the work that I have carried out in the Laboratory of Neurophysiolgy at the Université Libre de Bruxelles, under the supervision of Prof. Serge Schiffmann, in collaboration with Prof. Stéphane Schurmans of Université of Liège.The work is divided in two distinct but related projects and the results section is thus divided into two main chapters. The results described are presented in the form of two manuscripts, the first chapter is named “Ciliary phosphoinositides regulation by INPP5E controls Shh signaling by allowing trafficking of Gpr161 in neural stem cells primary cilium”.The second is named “Regulation of phosphoinositides ciliary levels controls trafficking and ciliogenesis in ependymal cells”.Since both manuscripts are comprehensive regarding the results, and methods, these are inserted as such into the thesis.An expanded introduction to the field, placing the results into context, precedes these two chapters. An extended discussion section follows each chapter; it presents some elements of discussion not included in the manuscripts, the implications of the results and the scope for further research.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished

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Neilson, Kirstie Jane. « Differentiation of mouse embryonic stem cells into endothelial progenitor cells ». Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500200.

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Addicks, Gregory Charles. « Epigenetic Regulation of Muscle Stem and Progenitor Cells ». Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37112.

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Epigenetic mechanisms are of fundamental importance for resolving and maintaining cellular identity. The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration and maintenance. Important roles for the trithorax H3K4 histone methyltransferase (HMT) MLL1 have been established for early embryogenesis, and for hematopoietic and neural identity. Here, using a conditional Mll1 knockout (KO), we find that in vivo, MLL1 is necessary for efficient muscle regeneration, and for maintenance and proliferation of muscle stem and progenitor cells. Loss of Mll1 in cultured myoblasts reveals an essential role for expression of the myogenic specification gene Pax7. Mll1 KO results in a minor decrease in Pax7 mRNA and a strong decrease of Pax7 protein. While MLL1 was found to bind the Pax7 promoter, Mll1 KO results in a minor decrease of H3K4me3 at Pax7, supporting a recognized non-HMT role for Mll1 at Pax7. Microarray analysis of mRNA expression in Mll1 KO myoblasts finds that Myf5 is the most strongly downregulated of all genes, unexpectedly, mRNA expression of previously identified MLL1 targets are unaffected by loss of MLL1 in myoblasts. Pax7 activates Myf5 expression through recruitment of a H3K4 HMT, and in Mll1 KO myoblasts expression of, and H3K4me3 at Myf5 is lost. Exogenous Pax7 rescues Myf5 expression and H3K4me3 at Myf5 in the absence of MLL1, indicating that Myf5 expression is conditional on Pax7, but not MLL1. We also show that Myf5 DNA is methylated in non-myogenic cells, and in satellite stem cells that have never expressed Myf5, but is not methylated in satellite cells that are committed to the myogenic lineage, indicating that demethylation of Myf5 may be a fundamental step in myogenic commitment. Intriguingly, Myf5 promoter DNA becomes remethylated in Mll1 KO myoblasts. This work finds that Pax7 expression and myogenic identity is partly dependent on MLL1 expression. Further, evidence is uncovered that myogenic commitment is initiated by demethylation of Myf5. These findings add to the understanding of the epigenetic mechanisms that regulate and define muscle stem cells.

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Schütte, Judith. « Analysis of regulatory networks in blood stem/progenitor cells ». Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648631.

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Ma, Kwai-yee Stephanie. « Identification and characterization of tumorigenic liver cancer stem/progenitor cells ». Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557534.

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Livres sur le sujet "Ependymal stem progenitor cells"

Reynolds, Brent A., et Loic P. Deleyrolle. Neural progenitor cells : Methods and protocols. New York : Humana Press, 2013.

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American Association of Blood Banks. Progenitor Cell Standards Task Force., dir. Standards for hematopoietic progenitor cells. Bethesda, Md : American Association of Blood Banks, 1996.

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E, Brecher Mark, dir. Hematopoietic progenitor cells : Processing, standards, and practice. Bethesda, Md : American Association of Blood Banks, 1995.

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Atala, Anthony. Progenitor and stem cell technologies and therapies. Cambridge, UK : Woodhead Publishing, 2012.

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American Association of Blood Banks., dir. Standards for hematopoietic progenitor cell services. 2^e éd. Bethesda, Md : American Association of Blood Banks, 2000.

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Co, Business Communications, dir. Stem cell and progenitor cell therapy : Current uses and future possibilities. Norwalk, CT : Business Communications Co., 2002.

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Arturo, Álvarez-Buylla, et García-Verdugo José Manuel, dir. Identification and characterization of neural progenitor cells in the adult mammalian brain. Berlin : Springer, 2009.

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American Association of Blood Banks. Standards for hematopoietic progenitor cell and cellular product services. 3^e éd. Bethesda, Md : American Association of Blood Banks, 2002.

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Progenitor cell therapy for neurological injury. New York : Humana Press, 2011.

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I, Moldovan Nicanor, dir. Novel angiogenic mechanisms : Role of circulating progenitor endothelial cells. New York : Kluwer Academic/Plenum, 2003.

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Chapitres de livres sur le sujet "Ependymal stem progenitor cells"

Cetrulo, Curtis L., et Margaret J. Starnes. « Perinatal Endothelial Progenitor Cells ». Dans Perinatal Stem Cells, 95–102. Hoboken, NJ, USA : John Wiley & Sons, Inc., 2010. http://dx.doi.org/10.1002/9780470480151.ch7.

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Keller, Patricia J., Lisa M. Arendt et Charlotte Kuperwasser. « Human Mammary Epithelial Stem/Progenitor Cells ». Dans Stem Cells Handbook, 235–44. New York, NY : Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7696-2_17.

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Itzhaki-Alfia, Ayelet, et Jonathan Leor. « Resident Cardiac Progenitor Cells ». Dans Adult and Pluripotent Stem Cells, 21–35. Dordrecht : Springer Netherlands, 2014. http://dx.doi.org/10.1007/978-94-017-8657-7_2.

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Horie, Nobutaka. « Neural Stem Cells/Neuronal Progenitor Cells ». Dans Cell Therapy Against Cerebral Stroke, 27–37. Tokyo : Springer Japan, 2017. http://dx.doi.org/10.1007/978-4-431-56059-3_3.

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Parolini, Ornella, Debashree De, Melissa Rodrigues et Maddalena Caruso. « Placental Stem/Progenitor Cells : Isolation and Characterization ». Dans Perinatal Stem Cells, 141–57. New York, NY : Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1118-9_13.

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Di Nardo, Paolo, et Francesca Pagliari. « Cardiac Progenitor Cell Extraction from Human Auricles ». Dans Adult Stem Cells, 145–54. New York, NY : Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6756-8_11.

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Rodewald, Hans-Reimer. « Epithelial Stem/Progenitor Cells in Thymus Organogenesis ». Dans Adult Stem Cells, 83–100. Totowa, NJ : Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-732-1_6.

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Honorio, Sofia, Hangwen Li et Dean G. Tang. « Prostate Cancer Stem/Progenitor Cells ». Dans Stem Cells and Cancer, 217–30. Totowa, NJ : Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-933-8_17.

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Geraerts, Martine, et Catherine M. Verfaillie. « Adult Stem and Progenitor Cells ». Dans Engineering of Stem Cells, 1–21. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/10_2008_21.

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Pedini, Francesca, Mary Anna Venneri et Ann Zeuner. « Hematopoietic Stem/Progenitor Cells : Response to Chemotherapy ». Dans Stem Cells and Cancer Stem Cells, Volume 6, 333–44. Dordrecht : Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-2993-3_29.

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Actes de conférences sur le sujet "Ependymal stem progenitor cells"

Sharma, Vishal P., et Michael E. Geusz. « Abstract 268 : Circadian rhythms of glioma stem cells and progenitor cells. » Dans Proceedings : AACR 104th Annual Meeting 2013 ; Apr 6-10, 2013 ; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-268.

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Hawkins, Finn J., Tyler Longmire, Laertis Oikonomou et Darrell N. Kotton. « Directed Differentiation Of Mouse Embryonic Stem Cells Into Primordial Lung Progenitor Cells ». Dans American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6348.

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Tao, Luwei, Amy Roberts, Karen Dunphy, Haoheng Yan et D. Joseph Jerry. « Abstract B61 : Regulation of mammary stem/progenitor cells by p53 ». Dans Abstracts : First AACR International Conference on Frontiers in Basic Cancer Research--Oct 8–11, 2009 ; Boston MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.fbcr09-b61.

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San, Isabelle V. Leefa Chong, Gaelle Prost et Ulrike Nuber. « Abstract A09 : Effects of Podocalyxin on neural stem/progenitor cells ». Dans Abstracts : AACR Special Conference : Advances in Brain Cancer Research ; May 27-30, 2015 ; Washington, DC. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.brain15-a09.

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Nguyen, T. S., D. Verma, C. Graf, D. S. Krause et W. Ruf. « EPCR Raft Signaling Controls Activity of Hematopoietic Progenitor and Stem Cells ». Dans 63rd Annual Meeting of the Society of Thrombosis and Haemostasis Research. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1680099.

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Lee, Y.-S., G. Collins et T. Livingston Arinzeh. « Neural differentiation of human neural stem/progenitor cells on piezoelectric scaffolds ». Dans 2010 36th Annual Northeast Bioengineering Conference. IEEE, 2010. http://dx.doi.org/10.1109/nebc.2010.5458264.

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Visvader, JE, et GJ Lindeman. « Abstract BL1 : Deciphering stem and progenitor cells to understand breast cancer ». Dans Abstracts : 2019 San Antonio Breast Cancer Symposium ; December 10-14, 2019 ; San Antonio, Texas. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.sabcs19-bl1.

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Lannagan, Tamsin, Susan Woods, Laura Vrbanac, Miao Yang, Jia Ng, Tongtong Wang, Yagnesh Tailor, Samuel Asfaha, Timothy Wang et Daniel L. Worthley. « Abstract 1721 : Desmoplasia stem and progenitor cells within the tumor microenvironment ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-1721.

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Yin, Gang, Vinny Craveiro, Jennie Holmberg, Han-Hsuan Fu, Michael K. Montagna, Ayesha Alvero et Gil Mor. « Abstract 3405 : Epithelial ovarian cancer stem cells are the source of metastatic progenitor cells ». Dans Proceedings : AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011 ; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3405.

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Lombardi, Sara, Christophe Ginestier, Gabriella Honeth, Ireneusz Shinomiya, Rebecca Marlow, Bharath Buchupalli, Patrycja Gazinska et al. « Abstract LB-190 : Growth hormone signaling in mammary stem and progenitor cells ». Dans Proceedings : AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012 ; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-lb-190.

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Rapports d'organisations sur le sujet "Ependymal stem progenitor cells"

Shull, James D. Mammary Stem/Progenitor Cells and Cancer Susceptibility. Fort Belvoir, VA : Defense Technical Information Center, juin 2012. http://dx.doi.org/10.21236/ada567916.

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Paguirigan, Amy L. Development of Micro-Scale Assays of Mammary Stem and Progenitor Cells. Fort Belvoir, VA : Defense Technical Information Center, juillet 2008. http://dx.doi.org/10.21236/ada487181.

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Sullivan, Genevieve M. The Regenerative Response of Endogenous Neural Stem/Progenitor Cells to Traumatic Brain Injury. Fort Belvoir, VA : Defense Technical Information Center, mai 2014. http://dx.doi.org/10.21236/ad1012867.

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Lewis, Michael T. Unmasking Stem/Progenitor Cell Properties in Differentiated Epithelial Cells Using Short-term Transplantation. Fort Belvoir, VA : Defense Technical Information Center, août 2006. http://dx.doi.org/10.21236/ada462432.

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Liu, Can. MicroRNA Regulation of CD44+ Prostate Tumor Stem/Progenitor Cells and Prostate Cancer Development/Metastasis. Fort Belvoir, VA : Defense Technical Information Center, mai 2013. http://dx.doi.org/10.21236/ada580115.

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Halevy, Orna, Sandra Velleman et Shlomo Yahav. Early post-hatch thermal stress effects on broiler muscle development and performance. United States Department of Agriculture, janvier 2013. http://dx.doi.org/10.32747/2013.7597933.bard.

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In broilers, the immediate post-hatch handling period exposes chicks to cold or hot thermal stress, with potentially harmful consequences to product quantity and quality that could threaten poultry meat marketability as a healthy, low-fat food. This lower performance includes adverse effects on muscle growth and damage to muscle structure (e.g., less protein and more fat deposition). A leading candidate for mediating the effects of thermal stress on muscle growth and development is a unique group of skeletal muscle cells known as adult myoblasts (satellite cells). Satellite cells are multipotential stem cells that can be stimulated to follow other developmental pathways, especially adipogenesis in lieu of muscle formation. They are most active during the first week of age in broilers and have been shown to be sensitive to environmental conditions and nutritional status. The hypothesis of the present study was that immediate post-hatch thermal stress would harm broiler growth and performance. In particular, growth characteristics and gene expression of muscle progenitor cells (i.e., satellite cells) will be affected, leading to increased fat deposition, resulting in long-term changes in muscle structure and a reduction in meat yield. The in vitro studies on cultured satellite cells derived from different muscle, have demonstrated that, anaerobic pectoralis major satellite cells are more predisposed to adipogenic conversion and more sensitive during myogenic proliferation and differentiation than aerobic biceps femoris cells when challenged to both hot and cold thermal stress. These results corroborated the in vivo studies, establishing that chronic heat exposure of broiler chicks at their first two week of life leads to impaired myogenicity of the satellite cells, and increased fat deposition in the muscle. Moreover, chronic exposure of chicks to inaccurate temperature, in particular to heat vs. cold, during their early posthatch periods has long-term effects of BW, absolute muscle growth and muscle morphology and meat quality. The latter is manifested by higher lipid and collagen deposition and may lead to the white striping occurrence. The results of this study emphasize the high sensitivity of muscle progenitor cells in the early posthatch period at a time when they are highly active and therefore the importance of rearing broiler chicks under accurate ambient temperatures. From an agricultural point of view, this research clearly demonstrates the immediate and long-term adverse effects on broiler muscling and fat formation due to chronic exposure to hot stress vs. cold temperatures at early age posthatch. These findings will aid in developing management strategies to improve broiler performance in Israel and the USA. BARD Report - Project4592 Page 2 of 29

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