Thèses sur le sujet « Enzyme »
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Ekici, Ozlem Dogan. « Design, synthesis, and evaluation of novel irreversible inhibitors for caspases ». Diss., Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/5333.
Texte intégralFinnigan, William John Andrew. « The exploitation of thermophiles and their enzymes for the construction of multistep enzyme reactions from characterised enzyme parts ». Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/27323.
Texte intégralMüller, Roger. « Artificial enzymes : from catalytic antibodies toward de novo enzyme design / ». Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17897.
Texte intégralReichstädter, Marek. « Imobilizace vybraných glykanohydroláz ». Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2015. http://www.nusl.cz/ntk/nusl-217152.
Texte intégralEkici, Özlem Doğan. « Design, synthesis, and evaluation of novel irreversible inhibitors for caspases ». Available online, Georgia Institute of Technology, 2004:, 2003. http://etd.gatech.edu/theses/available/etd-04062004-164633/unrestricted/ekici%5Fozlem%5Fd%5F200312%5Fphd.pdf.
Texte intégralObrecht, Lorenz. « Artificial metalloenzymes in catalysis ». Thesis, University of St Andrews, 2015. http://hdl.handle.net/10023/7248.
Texte intégralBodhe, A. M. « Enzyme inhibitors ». Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1988. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3302.
Texte intégralQian, Yuhui. « Study of Basic Wood Decay Mechanisms and Their Biotechnological Applications ». Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/QianY2008.pdf.
Texte intégralZhao, Xueyan. « Nanoscale biocatalysts for bioelectrochemical applications ». Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1164149161.
Texte intégral"December, 2006." Title from electronic thesis title page (viewed 06/27/2007) Advisor, Ping Wang; Committee members, Lu-Kwang Ju, Steven S. C. Chuang; Department Chair, Lu-Kwang Ju; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
Moore, Robert Goodwin Douglas C. « Towards the understanding of complex biochemical systems the significance of global protein structure and thorough parametric analysis / ». Auburn, Ala, 2009. http://hdl.handle.net/10415/1766.
Texte intégralAstier, Yann. « Enzyme kinetics and electrochemical polymer transistor detection of enzyme reactions ». Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273800.
Texte intégralEwing, Erin. « In vacuo glycation of enzymes : A novel approach for increasing enzyme stability ». Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27129.
Texte intégralMao, Wei. « Etude biochimique et sélection d'inhibiteurs spécifiques d'une cible thérapeutique leishmanienne : la GDP-Mannose-Pyrophosphorylase ». Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS481.
Texte intégralLeishmaniases are Neglected Tropical Disease (NTD)caused by a protozoan parasite of the genus Leishmania and transmitted by an insect vector, the phlebotomine sandfly. Leishmaniases threaten 310 millions people in 98 countries around the world. Current antileishmanial treatments are limited and present major issues of toxicity and drug resistance emergence. In this context, it is necessary to develop new specific antileishmanial drugs specifically directed against a therapeutic target in the parasite.The GDP-Mannose Pyrophosphorylase (GDP-MP) is a therapeutic target which has been described to be essential for parasite survival both in vitro and in vivo. Several differences have been identified in the active site of leishmanial GDP-MPs compared to the human counterpart, showing the prominence of this therapeutic target in the development of new treatments against leishmaniasis. The GDP-MP catalyzes the synthesis of GDP-Mannose,the activated form of mannose, an important molecular constituent of the glycosylation processes involved in the biosynthesis of glycoconjugates which are essential for host-parasite recognition. My thesis work consisted in the production and purification of GDP-MPs from 3 Leishmania species (Leishmania donovani,Leishmania infantum and Leishmania mexicana)and from humanin order to compare their enzymatic properties. From potential inhibitors designed and synthesized on the basis of leishmanial and human GDP-MP molecular models, 100 compounds were evaluated on purified enzymes and on parasites in vitro. These analyses allowed us to select some compounds which are specifically directed against the parasite target and presenting antileishmanial activities. We have also initiated a study of expression and localization of GDP-MP after treatment with the most potent compounds. These compounds will be used as pharmacological tools for the development of new specific antileishmanial drugs
Robertson, Graeme. « Enzyme pesticide biosensors ». Thesis, University of Strathclyde, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366815.
Texte intégralBirkin, Peter Robert. « Microelectrochemical enzyme transistors ». Thesis, University of Southampton, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240628.
Texte intégralWilson, Robert. « Enzyme amplified immunoassays ». Thesis, Cranfield University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237805.
Texte intégralAl-Lolage, Firas Ahmed Thanon. « Amperometric enzyme electrodes ». Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/419053/.
Texte intégralBolon, Daniel N. Goddard William A. « Computational enzyme design / ». Diss., Pasadena, Calif. : California Institute of Technology, 2002. http://resolver.caltech.edu/CaltechETD:etd-01252002-100801.
Texte intégralSILVA, JOSE A. A. da. « Aspectos de atividade biologica da giroxina (enzima trombina simile) isolada do veneno da cascavel brasileira, Crotalus durissus terrificus ». reponame:Repositório Institucional do IPEN, 2004. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11191.
Texte intégralMade available in DSpace on 2014-10-09T14:02:30Z (GMT). No. of bitstreams: 1 09994.pdf: 3905779 bytes, checksum: 7cdc8d8ae9585729a6a818ed202c59c8 (MD5)
Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Epstein, Todd Matthew. « Structural and kinetic studies of two enzymes catalyzing phospholipase A2 activity ». Access to citation, abstract and download form provided by ProQuest Information and Learning Company ; downloadable PDF file 2.39 Mb., 186 p, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3200538.
Texte intégralSnider, Catherine E. « Synthesis and biochemical evaluation of irreversible inhibitors of aromatase / ». The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266362338344.
Texte intégralHaileselassie, Seble Sereke Berhan. « Production of enzyme-modified cheese and bioactive peptides by Lactobacillus and commercial enzymes ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ50782.pdf.
Texte intégralDong, Liang-Chang. « Thermally reversible hydrogels for controlled drug delivery and enzyme immobilization / ». Thesis, Connect to this title online ; UW restricted, 1990. http://hdl.handle.net/1773/8009.
Texte intégralO'Neil, Crystal L. « Enzyme Exploitation : Manipulating Enzyme Function for Therapy, Synthesis and Natural Product Modification ». The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1293722936.
Texte intégralFriemann, Rosmarie. « Structure-function studies of iron-sulfur enzyme systems / ». Uppsala : Dept. of Molecular Biology, Swedish Univ. of Agricultural Sciences, 2005. http://epsilon.slu.se/a504.pdf.
Texte intégralWilliams, Simon-Peter. « Studies of enzyme kinetics and aspects of enzyme structure in vivo using NMR and molecular genetics ». Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:d8baa574-a5d4-45a2-95a2-c141fbf8d277.
Texte intégralLee, Charles Kai-Wu. « Eurythermalism of a deep-sea symbiosis system from an enzymological aspect ». The University of Waikato, 2007. http://hdl.handle.net/10289/2588.
Texte intégralGavva, Sandhya Reddy. « Alternate Substrates and Isotope Effects as a Probe of the Malic Enzyme Reaction ». Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc330840/.
Texte intégralPeters, Thilo. « Extrazelluläre Enzyme aus Basidiomyceten ». [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97236191X.
Texte intégralYAMANE, Tsuneo. « Enzyme Engineering for Lipids ». 名古屋大学農学国際教育協力研究センター, 2004. http://hdl.handle.net/2237/8930.
Texte intégralWilliams, Richard James. « Enzyme assisted self-assembly ». Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496231.
Texte intégralBeh, Seng Kee. « Membranes for enzyme electrodes ». Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305091.
Texte intégralZaman, Flora. « Kinetics of enzyme models ». Thesis, University of Kent, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263701.
Texte intégralParratt, Julian Simon. « Enzyme catalysed nitrile hydrolysis ». Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357898.
Texte intégralDennison, Manus. « Gas-phase enzyme biosensors ». Thesis, Cranfield University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309584.
Texte intégralHall, Geoffrey F. « Organic phase enzyme electrodes ». Thesis, Cranfield University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278720.
Texte intégralSaini, S. « Organic phase enzyme electrodes ». Thesis, Cranfield University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332925.
Texte intégralKalia, Yogeshvar Nath. « Development of enzyme electrodes ». Thesis, Imperial College London, 1991. http://hdl.handle.net/10044/1/46856.
Texte intégralCoote, Alexander Stuart. « Polyurethanes for enzyme immobilisation ». Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47386.
Texte intégralSutar, I. I. « Studies on proteolytic enzyme ». Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 1987. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3285.
Texte intégralOudshoorn, Matthew Leslie. « Tests of predictions made by the Equilibrium Model for the effect of temperature on enzyme activity ». The University of Waikato, 2008. http://hdl.handle.net/10289/2418.
Texte intégralSilveira, Alvito J. « Synthesis of 6-guanidinobenzoxazinones as potential inhibitors of trypsin-like enzymes ». Thesis, Georgia Institute of Technology, 1989. http://hdl.handle.net/1853/26914.
Texte intégralGarrett, Mark Denis. « A study on selectivity in microbial biotransformations of substituted arenes ». Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287620.
Texte intégralSha, Zhou. « A Chemical Approach to Detect and Characterize The Activities of Mitochondrial ATP-dependent Protease Lon and ClpXP ». Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1595239191845497.
Texte intégralFisher, Oriana. « Subcloning, enzymatic characterization, and in silico docking of transglutaminase 2 ». Waltham, Mass. : Brandeis University, 2009. http://dcoll.brandeis.edu/handle/10192/23253.
Texte intégralVögeli, Bastian [Verfasser], et Tobias [Akademischer Betreuer] Erb. « Control of reactive intermediates in enzymes and enzyme complexes / Bastian Vögeli ; Betreuer : Tobias Erb ». Marburg : Philipps-Universität Marburg, 2019. http://d-nb.info/1185068716/34.
Texte intégralMaheshwari, Sweta. « Caractérisation biochimique et cellulaire des enzymes clés du métabolisme des phospholipides chez Plasmodium falciparum ». Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20004.
Texte intégralPhospholipids are essential for the growth and development of Plasmodium falciparum malaria parasite. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are its major structural phospholipids. This study focused on CTP: phosphoethanolamine cytidylyltransferase (ECT) and CTP: phosphocholine cytidylyltransferase (CCT) that catalyzes the rate-limiting steps of the de novo Kennedy pathways for PE and PC biosynthesis respectively. Both ECT and CCT are essential in the rodent malaria parasite P. berghei and constitute potential chemotherapeutic targets to fight against malaria. PfCCT consists of two very similar cytidylyltransferase (CT) domains whereas the human enzyme consists of only one CT domain. The presence of two CT domains in ECT seems to be widespread in all the organisms. Sequence and structural analysis showed that the C-terminal CT domain of ECT lacks key residues in the substrate binding motif. This study aimed at unravelling the enzymatic properties and cellular characteristics of PfECT and PfCCT enzymes. In addition, these studies addressed the key question if C-terminal CT domain of PfECT is catalytically active. Kinetic parameters of the enzymes were evaluated in vitro on native proteins as well as on recombinant proteins, the latter being produced in bacterial system. Cellular characterisation studies using polyclonal antisera showed that PfECT and PfCCT are expressed throughout the intra-erythrocytic life cycle of the parasite. PfECT is found mainly in soluble form in the parasite while PfCCT is present in soluble as well as insoluble forms in the parasite. Furthermore, immunofluorescence studies for PfECT revealed that it is mainly cytosolic. To assess the contribution of each CT domain to overall PfECT enzyme activity, recombinant PfECT mutants were generated by site-directed mutagenesis. Kinetic studies on these mutants indicated that the N-terminal CT domain was the only active domain of PfECT. Collectively, these results bring new insights into the kinetic and cellular properties of the enzymes and will pave the way in developing a future pharmacological approach
Chiu, May Leung. « Investigation and characterization of analyte-reporter enzyme conjugates for the enzyme-multiplied immunoassay technique ». Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1930910331&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Texte intégralFedatto, Luciana Maria. « Caracterização de proteases extracelulares produzidas por Xylella fastidiosa de citros e videira ». Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/91/91131/tde-21062005-134055/.
Texte intégralXylella fastidiosa is a pathogenic bacterium found in several plants. These bacteria secrete extracellular proteases into the culture broth as visualized in sodium-dodecyl-sulfate polyacrylamide activity gels containing gelatin as a co-polymerized substrate. Three major protein bands were produced by strain X0 (citrus) with molar masses (MM) of 122, 84 and 65 kDa. Grape strain 9713 produced two bands of approximately 84 and 64 kDa. These organisms produced zones of hydrolysis in agar plates amended with gelatin, casein and hemoglobin. Gelatin was the best substrate for these proteases. SDS-PAGE activity gel indicated that the protease activities of X. fastidiosa from citrus and grape were completely inhibited by PMSF and partially inhibited by EDTA. The optimal temperature for protease activity was 30oC with an optimal pH of 7.0. Among the proteolytic enzymes secreted by the phytopathogen, chitinase and β-1,3-glucanase activities were also detected in cultures of X. fastidiosa (citrus). From these results, it is suggested that these proteases produced by strains of X. fastidiosa from citrus and grape, belong to the serine- and metallo-protease group.
Preneta, A. Z. « Studies on lactate oxidising enzymes and their application to ferrocene-based enzyme electrodes for lactate ». Thesis, Cranfield University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376191.
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