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Auteur : Grafiati
Publié le 11 septembre 2023

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1

Terada, Kazutoyo, Masaki Kanazawa, Bernd Bukau et Masataka Mori. « The Human DnaJ Homologue dj2 Facilitates Mitochondrial Protein Import and Luciferase Refolding ». Journal of Cell Biology 139, no 5 (1 décembre 1997) : 1089–95. http://dx.doi.org/10.1083/jcb.139.5.1089.

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DnaJ homologues function in cooperation with hsp70 family members in various cellular processes including intracellular protein trafficking and folding. Three human DnaJ homologues present in the cytosol have been identified: dj1 (hsp40/hdj-1), dj2 (HSDJ/hdj-2), and neuronal tissue-specific hsj1. dj1 is thought to be engaged in folding of nascent polypeptides, whereas functions of the other DnaJ homologues remain to be elucidated. To investigate roles of dj2 and dj1, we developed a system of chaperone depletion from and readdition to rabbit reticulocyte lysates. Using this system, we found that heat shock cognate 70 protein (hsc70) and dj2, but not dj1, are involved in mitochondrial import of preornithine transcarbamylase. Bacterial DnaJ could replace mammalian dj2 in mitochondrial protein import. We also tested the effects of these DnaJ homologues on folding of guanidine-denatured firefly luciferase. Unexpectedly, dj2, but not dj1, together with hsc70 refolded the protein efficiently. We propose that dj2 is the functional partner DnaJ homologue of hsc70 in the mammalian cytosol. Bacterial DnaJ protein could replace mammalian dj2 in the refolding of luciferase. Thus, the cytosolic chaperone system for mitochondrial protein import and for protein folding is highly conserved, involving DnaK and DnaJ in bacteria, Ssa1–4p and Ydj1p in yeast, and hsc70 and dj2 in mammals.
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Requejo-Aguilar, Raquel, Irene Lopez-Fabuel, Daniel Jimenez-Blasco, Emilio Fernandez, Angeles Almeida et Juan P. Bolaños. « DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating pink1 ». Biochemical Journal 467, no 2 (2 avril 2015) : 303–10. http://dx.doi.org/10.1042/bj20141025.

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DnaJ-1 or hsp40/hdj-1 (DJ1) is a multi-functional protein whose mutations cause autosomal recessive early-onset Parkinson's disease (PD). DJ1 loss of function disrupts mitochondrial function, but the signalling pathway, whereby it interferes with energy metabolism, is unknown. In the present study, we found that mouse embryonic fibroblasts (MEFs) obtained from DJ1-null (dj1−/−) mice showed higher glycolytic rate than those from wild-type (WT) DJ1 (dj1+/+). This effect could be counteracted by the expression of the full-length cDNA encoding the WT DJ1, but not its DJ1-L166P mutant form associated with PD. Loss of DJ1 increased hypoxia-inducible factor-1α (Hif1α) protein abundance and cell proliferation. To understand the molecular mechanism responsible for these effects, we focused on phosphatase and tensin homologue deleted on chromosome 10 (PTEN)-induced protein kinase-1 (Pink1), a PD-associated protein whose loss was recently reported to up-regulate glucose metabolism and to sustain cell proliferation [Requejo-Aguilar et al. (2014) Nat. Commun. 5, 4514]. Noticeably, we found that the alterations in glycolysis, Hif1α and proliferation of DJ1-deficient cells were abrogated by the expression of Pink1. Moreover, we found that loss of DJ1 decreased pink1 mRNA and Pink1 protein levels and that DJ1, by binding with Foxo3a (forkhead box O3a) transcription factor, directly interacted with the pink1 promoter stimulating its transcriptional activity. These results indicate that DJ1 regulates cell metabolism and proliferation through Pink1.
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Bednarikova, Marketa, Petra Vinklerova, Jana Gottwaldova, Petra Ovesna, Jitka Hausnerova, Lubos Minar, Michal Felsinger, Dalibor Valik, Zdenka Cermakova et Vit Weinberger. « The Clinical Significance of DJ1 and L1CAM Serum Level Monitoring in Patients with Endometrial Cancer ». Journal of Clinical Medicine 10, no 12 (15 juin 2021) : 2640. http://dx.doi.org/10.3390/jcm10122640.

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Circulating tumor markers are not routinely used in patients with endometrial cancer (EC). This pilot study evaluated the role of monitoring new biomarkers DJ1 and L1CAM, in correlation with CA125 and HE4, for the effects of anticancer treatment and preoperative management in EC patients. Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. Serum DJ1, L1CAM, CA125 and HE4 levels were significantly higher at the time of diagnosis compared to those measured during follow-up (FU). In patients with recurrent disease, serum DJ1, CA125 and HE4 levels were significantly higher at the time of recurrence compared to levels in disease-free patients. Serum L1CAM levels were also higher in patients with recurrence but without reaching statistical significance. While DJ1 levels were not affected by any of the observed patient-related characteristics, L1CAM levels were significantly higher in patients with age ≥60 years who were overweight. At the time of EC diagnosis, DJ1 and L1CAM serum levels did not correlate with stage, histological type or risk of recurrence. This is a preliminary description of the potential of serial DJ1 and L1CAM serum level measurement for monitoring the effects of treatment in EC patients.
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Jonas, Elizabeth A., Emma Lazrove, Panah Nabili et Kambiz N. Alavian. « DJ1 regulates Neuronal Mitochondrial Bioenergetic Efficiency ». Biophysical Journal 104, no 2 (janvier 2013) : 657a. http://dx.doi.org/10.1016/j.bpj.2012.11.3628.

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Zhao, Miao, Bingwei Wang, Chenyu Zhang, Zhijie Su, Bingbing Guo, Yun Zhao et Ruimao Zheng. « The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease ». Cell Death & ; Differentiation 28, no 8 (24 mars 2021) : 2517–35. http://dx.doi.org/10.1038/s41418-021-00767-2.

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AbstractThe pathogenesis of Parkinson’s disease (PD) remains unclear, and there is no disease-modifying agent for PD. Withaferin A (WA), a naturally occurring compound, has emerged as a neuroprotective agent. However, the mechanisms by which WA is neuroprotective in PD are unknown. Here we show that WA protected against loss of dopaminergic neurons, neuroinflammation, and motor deficits in MPTP-induced PD mouse models. Whole-genome deep sequencing analysis combined with Meta-analysis of human PD studies reveal that DJ1, Nrf2, and STING in substantia nigra pars compacta (SNc) are linked to anti-PD effect of WA. We found that WA activated DJ1 and Nrf2, and suppressed STING within SNc; and overexpression of STING in SNc dampened the effect of WA. Using genetically modified mice (DJ1-KO, Nrf2-KO, STINGgt/gt and STING-KO) and immunolabeling technique, we identified that WA targeted DJ1-Nrf2-STING pathway in dopaminergic neurons; and we demonstrate that STING might be an important factor in PD pathogenesis. In addition, WA alleviated accumulation of phosphorylated α-synuclein (p-α-syn) and insoluble α-syn within SNc in adeno-associated virus (AAV)-mediated human α-syn overexpression PD model. Our comparative analysis on whole-genome transcriptome profiles suggests that STING might be a key target of WA and amantadine in PD treatment. This study highlights a multifaceted role for WA in neuroprotection, and suggests that WA can be a potential candidate for treatment of PD.
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Nair, Divya N., Rajesh Prasad, Neha Singhal, Manish Bhattacharjee, Renu Sudhakar, Pushpa Singh, Subramonian Thanumalayan, Uday Kiran, Yogendra Sharma et Puran Singh Sijwali. « A conserved human DJ1-subfamily motif (DJSM) is critical for anti-oxidative and deglycase activities of Plasmodium falciparum DJ1 ». Molecular and Biochemical Parasitology 222 (juin 2018) : 70–80. http://dx.doi.org/10.1016/j.molbiopara.2018.05.003.

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Meiser, Johannes, Alexei Vazquez et Karsten Hiller. « DJ1 at the interface between neuro-degeneration and cancer ». Oncotarget 8, no 6 (29 janvier 2017) : 9015–16. http://dx.doi.org/10.18632/oncotarget.14889.

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Maraganore, D. M., K. Wilkes, T. G. Lesnick, K. J. Strain, M. de Andrade, W. A. Rocca, J. H. Bower, J. E. Ahlskog, S. Lincoln et M. J. Farrer. « A limited role for DJ1 in Parkinson disease susceptibility ». Neurology 63, no 3 (9 août 2004) : 550–53. http://dx.doi.org/10.1212/01.wnl.0000133402.78621.ad.

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Ho, Kuo-Ling, Bin Lin, Yu-You Chen et Duu-Jong Lee. « Biodegradation of phenol using Corynebacterium sp. DJ1 aerobic granules ». Bioresource Technology 100, no 21 (novembre 2009) : 5051–55. http://dx.doi.org/10.1016/j.biortech.2009.05.050.

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Wang, I.-Lin, Yi-Ming Chen, Ke-Ke Zhang, Yu-Ge Li, Yu Su, Chou Wu et Chun-Sheng Ho. « Influences of Different Drop Height Training on Lower Extremity Kinematics and Stiffness during Repetitive Drop Jump ». Applied Bionics and Biomechanics 2021 (3 mars 2021) : 1–9. http://dx.doi.org/10.1155/2021/5551199.

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Drop jump (DJ) is often used as a plyometric exercise to improve jumping performance. Training from improper drop heights and for improper durations lead to unfavorable biomechanical changes in the lower extremities when landing, which result in reduced training effects and even lower extremity injuries. Purpose. To study the effects of repeated DJ training at drop heights of 30 cm, 40 cm, and 50 cm (drop jump height (DJH) 30, DJH40, and DJH50) on lower extremity kinematics and kinetics. The 1st, 50th, 100th, 150th, and 200th DJs (DJ1, DJs50, DJs100, DJs150, and DJs200) were recorded by using a BTS motion capture system and force platform. The MATLAB software was used to compare the kinematic and stiffness data of DJ1, DJs50, DJs100, DJs150, and DJs200 with one-way ANOVA repeated measure. If there were significant differences, the LSD method was used for post hoc comparisons. Methods. Twenty healthy male Division III athlete volunteers were selected as subjects, and 200 drop jumps (DJs200) were performed from DJH30, DJH40, and DJH50. Results. The jumping height (JH), contact time (CT), and GRF increased with drop height, and the stiffness of the legs and ankle at DJH30 was higher than that at DJH40 and DJH50 ( p < 0.05 ). Conclusion. Within DJs200, training at DJH50 yield the high impact easily leads to lower extremity injury; training at DJH30 can increase the stiffnesses of the legs and ankle joints, thus effectively utilizing the SSC benefits to store and release elastic energy, reducing the risk of lower extremity musculoskeletal injury. Therefore, coaches can choose different drop heights and training quantities for each person to better prevent lower extremity injury.
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Chen, Calvin Yu-Chian. « Mechanism of BAG1 repair on Parkinson’s disease-linked DJ1 mutation ». Journal of Biomolecular Structure and Dynamics 30, no 1 (mai 2012) : 1–12. http://dx.doi.org/10.1080/07391102.2012.674182.

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Bras, Jose M., Rita J. Guerreiro, James T. H. Teo, Lee Darwent, Jenny Vaughan, Sophie Molloy, John Hardy et Susanne A. Schneider. « Atypical Parkinsonism-Dystonia Syndrome Caused by a Novel DJ1 Mutation ». Movement Disorders Clinical Practice 1, no 1 (avril 2014) : 45–49. http://dx.doi.org/10.1002/mdc3.12008.

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Abbas, Masoom M., Shyla T. Govindappa, Sumedha Sudhaman, B. K. Thelma, Ramesh C. Juyal, Madhuri Behari et Uday B. Muthane. « Early Onset Parkinson's disease due to DJ1 mutations : An Indian study ». Parkinsonism & ; Related Disorders 32 (novembre 2016) : 20–24. http://dx.doi.org/10.1016/j.parkreldis.2016.04.024.

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van Horssen, Jack, Joost A. R. Drexhage, Thomas Flor, Wouter Gerritsen, Paul van der Valk et Helga E. de Vries. « Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions ». Free Radical Biology and Medicine 49, no 8 (1 novembre 2010) : 1283–89. http://dx.doi.org/10.1016/j.freeradbiomed.2010.07.013.

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Soares, Bárbara Emanuelle Alves Silva, Virgínia Cabral Benício, Havena Mariana dos Santos Souza, Emerson Iago Garcia e. Silva, Marianne Louise Marinho Mendes et Cristhiane Maria Bazílio de Omena Messias. « Caracterização físico-química de doce cremoso funcional do fruto do juazeiro (Ziziphus joazeiro Mart.) ». Research, Society and Development 11, no 9 (11 juillet 2022) : e33411931772. http://dx.doi.org/10.33448/rsd-v11i9.31772.

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Os doces em pasta e em pedaço são considerados produtos que auxiliam o desenvolvimento das regiões que os produzem e são uma boa forma de aproveitamento e conservação das frutas. Todavia, a literatura científica é muito escassa quanto à adição de probióticos em doces. Objetivou-se desenvolver um doce cremoso funcional a partir do fruto do juazeiro com adição de frutoligossacarídeo (FOS) e explorar suas características físico-químicas e nutricionais. Foram desenvolvidas duas formulações de doces cremosos: DJP (controle) contendo apenas polpa, sacarose (60%) e suco de limão; e DJ1 contendo polpa, sacarose (30%), FOS (10%) e suco de limão. Os produtos foram avaliados quanto à caracterização físico-química e nutricional. Os teores de umidade, cinzas, fibra bruta, lipídeo e proteína foram maiores (p<0,05) nos doces acrescidos de FOS (38,4%; 1,11%; 1,72%; 0,05% e 1,22% respectivamente). Já o pH, acidez titulável, Brixº, carboidratos e calorias totais foram maiores (p<0,05) para o doce controle sem FOS (5,03; 55,3º; 96,9% e 390,62 Kcal/100g respectivamente). Os compostos fenólicos foram superiores no DJ1, enquanto a atividade antioxidante não diferiu significativamente (p <0,05). As formulações demonstraram características físico-químicas e nutricionais apropriadas para sua utilização, destacando-se os compostos bioativos e fibras. O doce experimental mostrou-se como uma opção funcional e inovadora.
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Alizadeh, P., C. Terroba Chambi, B. Achen, K. Cantu Flores et V. Bruno. « P.024 Pain in monogenic Parkinson’s Disease ». Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 50, s2 (juin 2023) : S64. http://dx.doi.org/10.1017/cjn.2023.128.

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Background: Pain is one of the most bothersome symptoms reported in Parkinson’s disease (PD), yet its underlying pathophysiological mechanisms are not well understood. Its prevalence and effects on quality of life in patients with monogenic forms of PD have not been systematically explored. Methods: Comprehensive literature review exploring the association between monogenic forms of PD (SNCA, PRKN, PINK1, DJ1, and LRRK2) and pain. We included pain in ATP13A2, VPS35, and GBA1 mutation carriers. After initial screening, sixty-five relevant articles were identified. Studies’ design, sample sizes, and pain outcome measures were highly heterogeneous. Results: Our review suggests that patients with some PD monogenic causes show a higher prevalence of specific pain subtypes. While painful foot dystonia is more frequently reported in SNCA and PRKN carriers, the last ones also describe frequent lower back pain mostly. Pain in general is most commonly reported in PINK1 mutation carriers followed by patients with LRRK2 mutations. Pain as an initial symptom and severe symptom is well described in GBA1-PD patients. There is limited and insufficient evidence to report on pain and ATP13A2, DJ1, and VPS35 mutations. Conclusions: Linking genetic profiles to pain outcomes may have a meaningful clinical impact, facilitating individualized treatment for pain in PD.
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Drapalo, Katarzyna, et Jaroslaw Jozwiak. « Parkin, PINK1 and DJ1 as possible modulators of mTOR pathway in ganglioglioma ». International Journal of Neuroscience 128, no 2 (28 août 2017) : 167–74. http://dx.doi.org/10.1080/00207454.2017.1366906.

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Lopez-Fabuel, Irene, Lucia Martin-Martin, Monica Resch-Beusher, Garikoitz Azkona, Rosario Sanchez-Pernaute et Juan P. Bolaños. « Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants ». Neurochemistry International 109 (octobre 2017) : 101–5. http://dx.doi.org/10.1016/j.neuint.2017.03.023.

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Hering, Robert, Karsten M. Strauss, Xiao Tao, Andreas Bauer, Dirk Woitalla, Eva-Maria Mietz, Slobodanka Petrovic et al. « Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7) ». Human Mutation 24, no 4 (30 août 2004) : 321–29. http://dx.doi.org/10.1002/humu.20089.

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Ljubojević, Mirjana, Katarina Šavikin, Gordana Zdunić, Sandra Bijelić, Snežana Mrđan, Marija Kozomara, Magdalena Pušić et Tijana Narandžić. « Selection of Mulberry Genotypes from Northern Serbia for ‘Ornafruit’ Purposes ». Horticulturae 9, no 1 (24 décembre 2022) : 28. http://dx.doi.org/10.3390/horticulturae9010028.

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The genus Morus L., mulberry, is an interesting taxonomic group on account of its existing genetic variability, functional food potential and commercial importance. Mulberry trees are found in a wide range of areas in Serbia, accounting for a large phenotypic diversity in its genetic resources. Tree and fruit characteristics of more than 300 mulberry specimens were surveyed, and 15 genotypes of Morus alba, Morus nigra and Morus rubra species were selected for further analyses. These were located at various sites in the province of Vojvodina, Serbia. The present study was undertaken to investigate the diversity of the collected material aiming to pre-select genotypes suitable for landscaping/ornamental and/or fruit production purposes. Genotypes BP 3/9, DT1, ZP3 and MR1 have semi-vigorous growth, dropping growth habits, different leaf shapes (ovate, oval, cordate) and leaf color (from light to dark green), corresponding to ornamental mulberries. In addition, the semi-vigorous genotype ZD1 with a spreading tree and interesting palmate-lobed leaves was distinguished as a unique genotype for landscaping purposes. The most vigorous annual shoot growth was detected in the ZP3 genotype (118.5 cm), followed by DT1 (108.2 cm), MR1 (101.8 cm) and ZP1 (100.5 cm) genotypes. Contrary, genotype DJ1 exhibited the lowest annual growth with only a 32.9 cm average length of the shoots. Due to the greater fruit mass (4.2–6.1 g), sweetness and acidity balance as well as chemical composition, genotypes BP 1/4, DJ1, MG, MR1, DT1 and ZP3 may be recommended for fresh consumption, while genotypes DJ1, DT1, MR1, ZD1, ZP1 and BP 3/9 could be appropriate for home processing. According to fruit chemical analyses, the most promising genotypes were MR1 and DT1 combining high soluble solids content (21.2% and 18.5%, respectively), total sugar content (17.41% and 15.20%, respectively) and ascorbic acid content (42.24 and 49.28 mg/%, respectively). Additionally, DT1 genotype was also characterized by the highest total phenolic content (221.08 mg 27 GAE/100 g fresh weight). The most ornamental genotypes from this study (BP 3/9, DT1, ZD1, ZP3 and MR1) combined with their pomological and chemical characterization can be recommended for edible gardening purposes due to both aesthetic appearance and nutritive value of the fruits.
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Narendra, Derek P., Risa Isonaka, Diana Nguyen, Alice B. Schindler, Angela D. Kokkinis, Debra Ehrlich, Tanya M. Bardakjian, David S. Goldstein, Tsao-Wei Liang et Pedro Gonzalez-Alegre. « Peripheral synucleinopathy in a DJ1 patient with Parkinson disease, cataracts, and hearing loss ». Neurology 92, no 23 (26 avril 2019) : 1113–15. http://dx.doi.org/10.1212/wnl.0000000000007614.

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Sironi, Francesca, Paola Primignani, Sara Ricca, Sara Tunesi, Michela Zini, Silvana Tesei, Roberto Cilia, Gianni Pezzoli, Manuela Seia et Stefano Goldwurm. « DJ1 analysis in a large cohort of Italian early onset Parkinson Disease patients ». Neuroscience Letters 557 (décembre 2013) : 165–70. http://dx.doi.org/10.1016/j.neulet.2013.10.048.

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Hanagasi, Hasmet A., Anamika Giri, Ece Kartal, Gamze Guven, Başar Bilgiç, Ann-Kathrin Hauser, Murat Emre et al. « A novel homozygous DJ1 mutation causes parkinsonism and ALS in a Turkish family ». Parkinsonism & ; Related Disorders 29 (août 2016) : 117–20. http://dx.doi.org/10.1016/j.parkreldis.2016.03.001.

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Wilhelmus, Micha M. M., Philip G. Nijland, Benjamin Drukarch, Helga E. de Vries et Jack van Horssen. « Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders ». Free Radical Biology and Medicine 53, no 4 (août 2012) : 983–92. http://dx.doi.org/10.1016/j.freeradbiomed.2012.05.040.

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Sukhorukov, Vladimir, Alina Magnaeva, Tatiana Baranich, Anna Gofman, Dmitry Voronkov, Tatiana Gulevskaya, Valeria Glinkina et Sergey Illarioshkin. « Brain Neurons during Physiological Aging : Morphological Features, Autophagic and Mitochondrial Contribution ». International Journal of Molecular Sciences 23, no 18 (14 septembre 2022) : 10695. http://dx.doi.org/10.3390/ijms231810695.

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Accumulating data suggest that the brain undergoes various changes during aging. Among them are loss of both white and gray matter, neurons and synapses degeneration, as well as oxidative, inflammatory, and biochemical changes. The above-mentioned age-related features are closely related to autophagy and mitochondria. Therefore, we aimed to reveal the most peculiar morphological features of brain nervous tissue and to characterize the expression of autophagy and mitochondrial immunohistochemical biomarkers in neurons of different human brain zones during aging. Counting the number of neurons as well as Microtubule-associated proteins 1A/1B light chain 3B (LC3B), Heat shock protein 70 (HSP70), Lysosome-associated membrane protein type 2A (LAMP2A), Alpha subunit of ATP synthase (ATP5A), and Parkinson disease protein 7 (DJ1) immunohistochemical staining were performed on FFPE samples of human prefrontal cortex, corpus striatum, and hippocampus obtained from autopsy. Statistical analysis revealed a loss of neurons in the studied elderly group in comparison to the young group. When the expression of macroautophagy (LC3B), chaperon-mediated autophagy (HSP70, LAMP2A), and mitochondrial respiratory chain complex V (ATP5A) markers for the young and elderly groups were compared, the latter was found to have a significantly higher rate of optical density, whilst there was no significance in DJ1 expression. These findings, while preliminary, suggest that both autophagy and mitochondria are involved in neuronal maintenance during aging and could indicate their potential role in adaptive mechanisms that occur in aging.
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Zhang, Ke-Ke, Yi-Ming Chen, Yu-Ge Li, Shun Yao, Yu Su et I.-Lin Wang. « Different Drop Heights in Bilateral Asymmetry and Interjoint Coordination during Repetitive Drop-Jumps ». Symmetry 13, no 9 (29 août 2021) : 1590. http://dx.doi.org/10.3390/sym13091590.

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The difference of drop heights will affect the biomechanics of lower extremities during drop-jump (DJ) landing. Therefore, this study explored the effects of drop heights and training volumes on interjoint coordination and the side-to-side asymmetry of the lower extremities during landing. Twenty males were randomly assigned to perform 200 DJs (DJs200) from 30, 40 and 50 cm (drop-jump height (DJH) 30, DJH40 and DJH50) platform. One-way ANOVA repeated measure, using MATLAB software, was used to compare the differences of interjoint coordination, side-to-side asymmetry of ground contact time (GCT) and the maximum impact in vertical ground-reaction forces peak (I-vGRFpeak) in the 1st, 50th, 100th, 150th and 200th jumps (DJ1, DJs50, DJs100, DJs150 and DJs200). To examine whether significant differences exist, the least significant difference’s (LSD) method was used for post-hoc comparison. The mean absolute relative phase (MARP) and deviation phase (DP) of hip–knee were lower than DJH50 at DJH30 and DJH40, while side-to-side asymmetry of GCT and I-vGRFpeak were greater than DJH30 and DJH40 at DJH50 within DJs200 (all p <0.05). However, there was no significant difference in MARP and DP of hip–ankle and knee–ankle. Therefore, training at DJH30 may effectively improve jumping performance and reduce musculoskeletal injury risk.
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Yang, Katie M., Katherine V. Blue, Haleigh M. Mulholland, Meghna P. Kurup, Cynthia A. Kelm-Nelson et Michelle R. Ciucci. « Characterization of oromotor and limb motor dysfunction in the DJ1 -/- model of Parkinson disease ». Behavioural Brain Research 339 (février 2018) : 47–56. http://dx.doi.org/10.1016/j.bbr.2017.10.036.

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Ghaderi, Shahrooz, Neda Alidadiani, Jafar SoleimaniRad, Hamid R. Heidari, Nafi Dilaver, Christian Heim, Martina Ramsperger-gleixner, Behzad Baradaran et Michael Weyand. « DJ1 and microRNA-214 act synergistically to rescue myoblast cells after ischemia/reperfusion injury ». Journal of Cellular Biochemistry 119, no 9 (28 mai 2018) : 7192–203. http://dx.doi.org/10.1002/jcb.26842.

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Kasten, Meike, Corinna Hartmann, Jennie Hampf, Susen Schaake, Ana Westenberger, Eva-Juliane Vollstedt, Alexander Balck et al. « Genotype-Phenotype Relations for the Parkinson's Disease Genes Parkin , PINK1 , DJ1 : MDSGene Systematic Review ». Movement Disorders 33, no 5 (11 avril 2018) : 730–41. http://dx.doi.org/10.1002/mds.27352.

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Ganesh, Aravind, et Steven Galetta. « Editors' note : Peripheral synucleinopathy in a DJ1 patient with Parkinson disease, cataracts, and hearing loss ». Neurology 94, no 21 (25 mai 2020) : 943.1–943. http://dx.doi.org/10.1212/wnl.0000000000009488.

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Namnah, Montaser, Orly Elpeleg, Marc Gotkine et David Arkadir. « Reader response : Peripheral synucleinopathy in a DJ1 patient with Parkinson disease, cataracts, and hearing loss ». Neurology 94, no 21 (25 mai 2020) : 943.2–944. http://dx.doi.org/10.1212/wnl.0000000000009495.

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Narendra, Derek P., Risa Isonaka, Diana Nguyen, Alice B. Schindler, Angela D. Kokkinis, Debra Ehrlich, Tanya M. Bardakjian, David S. Goldstein, Tsao-Wei Liang et Pedro Gonzalez-Alegre. « Author response : Peripheral synucleinopathy in a DJ1 patient with Parkinson disease, cataracts, and hearing loss ». Neurology 94, no 21 (25 mai 2020) : 944.1–944. http://dx.doi.org/10.1212/wnl.0000000000009502.

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Robson, Arthur J., et Larry Samuelson. « The Evolution of Time Preference with Aggregate Uncertainty ». American Economic Review 99, no 5 (1 décembre 2009) : 1925–53. http://dx.doi.org/10.1257/aer.99.5.1925.

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We examine the evolutionary foundations of intertemporal preferences. When all the risk affecting survival and reproduction is idiosyncratic, evolution selects for agents who maximize the discounted sum of expected utility, discounting at the sum of the population growth rate and the mortality rate. Aggregate uncertainty concerning survival rates leads to discount rates that exceed the sum of population growth rate and death rate, and can push agents away from exponential discounting. (JEL D11, D81, D91)
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Chakraborty, Anujit, Yoram Halevy et Kota Saito. « The Relation between Behavior under Risk and over Time ». American Economic Review : Insights 2, no 1 (1 mars 2020) : 1–16. http://dx.doi.org/10.1257/aeri.20190051.

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The paper establishes a tight relation between nonstandard behaviors in the domains of risk and time, by considering a decision-maker with non-expected utility preferences who believes that only present consumption is certain while any future consumption is uncertain. We provide the first complete characterizations of the two-way relations between the certainty effect and present bias, and between the common ratio effect and temporal reversals. (JEL D11, D15, D81, D91)
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Danan, Eric, Thibault Gajdos et Jean-Marc Tallon. « Harsanyi's Aggregation Theorem with Incomplete Preferences ». American Economic Journal : Microeconomics 7, no 1 (1 février 2015) : 61–69. http://dx.doi.org/10.1257/mic.20130117.

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We provide a generalization of Harsanyi's (1955) aggregation theorem to the case of incomplete preferences at the individual and social level. Individuals and society have possibly incomplete expected utility preferences that are represented by sets of expected utility functions. Under Pareto indifference, social preferences are represented through a set of aggregation rules that are utilitarian in a generalized sense. Strengthening Pareto indifference to Pareto preference provides a refinement of the representation. (JEL D01, D11, D71)
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Kumar, Narayan, Chaithanya Venkata Krishna Ponnaluri, Aarthi Putarjunan, Sridevi Ranganathan, Utpal Roy et Ashis Das. « Characterization of temperature inducible promoters from a novel rolling circle replicating plasmid of Enterococcus faecium DJ1 ». Plasmid 67, no 3 (mai 2012) : 211–26. http://dx.doi.org/10.1016/j.plasmid.2011.12.002.

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Merikallio, Heta, Paavo Pääkkö, Vuokko L. Kinnula, Terttu Harju et Ylermi Soini. « Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer ». Human Pathology 43, no 4 (avril 2012) : 577–84. http://dx.doi.org/10.1016/j.humpath.2011.05.024.

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Xu, Changshui, Jun Xu, Yanmin Zhang, Jianjun Ma, Hideshi Kawakami, Hirofumi Maruyama et Masaki Kamada. « Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease ». Neurology Research International 2010 (2010) : 1–4. http://dx.doi.org/10.1155/2010/674740.

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Objective. To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD).Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine-rich repeat kinase 2(LRRK2), PINK1(PTEN-induced putative kinase 1), PARK7(Protein DJ1), PARK2(Parkinson juvenile disease protein 2), the glucocerebrosidase (GBA), and ATP(Ezrin-binding protein PACE-1), were sequenced by the use of polymerase chain reaction (PCR) technique. The gene dose of SNCA was checked.Results. There were only two missense mutations observed, respectively, at exon 5 of LRRK2 and exon 10 of PARK2, and both were enrolled in SNPs.Conclusion. No meaningful mutations could be detected, and other susceptibility genes should be detected in FDP patients in China.
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Bernheim, B. Douglas, Luca Braghieri, Alejandro Martínez-Marquina et David Zuckerman. « A Theory of Chosen Preferences ». American Economic Review 111, no 2 (1 février 2021) : 720–54. http://dx.doi.org/10.1257/aer.20190390.

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We propose and develop a dynamic theory of endogenous preference formation in which people adopt worldviews that shape their judgments about their experiences. The framework highlights the role of mindset flexibility, a trait that determines the relative weights the decision-maker places on her current and anticipated worldviews when evaluating future outcomes. The theory generates rich behavioral dynamics, thereby illuminating a wide range of applications and providing potential explanations for a variety of observed phenomena. (JEL D11, D81, D91, Z13)
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Gul, Faruk, Wolfgang Pesendorfer et Tomasz Strzalecki. « Coarse Competitive Equilibrium and Extreme Prices ». American Economic Review 107, no 1 (1 janvier 2017) : 109–37. http://dx.doi.org/10.1257/aer.20141287.

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We introduce a notion of coarse competitive equilibrium, to study agents’ inability to tailor their consumption to prices. Our goal is to incorporate limited cognitive ability (in particular limited attention, memory, and complexity) into the analysis of competitive equilibrium. Compared to standard competitive equilibrium, our concept yields more extreme prices and, when all agents have the same endowment, riskier allocations. We provide a tractable model suitable for general equilibrium analysis as well as asset pricing. (JEL D11, D51, D91, G10)
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Krasko, Maryann N., Jesse D. Hoffmeister, Nicole E. Schaen-Heacock, Jacob M. Welsch, Cynthia A. Kelm-Nelson et Michelle R. Ciucci. « Rat Models of Vocal Deficits in Parkinson’s Disease ». Brain Sciences 11, no 7 (13 juillet 2021) : 925. http://dx.doi.org/10.3390/brainsci11070925.

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Parkinson’s disease (PD) is a progressive, degenerative disorder that affects 10 million people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a motor speech disorder that impairs vocal communication and quality of life. Despite the prevalence of vocal deficits in this population, very little is known about the pathological mechanisms underlying this aspect of disease. As such, effective treatment options are limited. Rat models have provided unique insights into the disease-specific mechanisms of vocal deficits in PD. This review summarizes recent studies investigating vocal deficits in 6-hydroxydopamine (6-OHDA), alpha-synuclein overexpression, DJ1-/-, and Pink1-/- rat models of PD. Model-specific changes to rat ultrasonic vocalization (USV), and the effects of exercise and pharmacologic interventions on USV production in these models are discussed.
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Kubler, Felix, Larry Selden et Xiao Wei. « Asset Demand Based Tests of Expected Utility Maximization ». American Economic Review 104, no 11 (1 novembre 2014) : 3459–80. http://dx.doi.org/10.1257/aer.104.11.3459.

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We provide conditions under which contingent claim and asset demands are consistent with state independent Expected Utility maximization. The paper focuses on the case of a single commodity and demands are allowed to be functions of probabilities and not just prices and income. We extend prior analyses by deriving three distinct tests for demands to be rationalized by Expected Utility: (i) a contingent claim analogue to the certainty strong axiom of revealed preference, (ii) a characterization of the functional form for demand, and (iii) necessary and sufficient conditions based on the Slutsky matrix. (JEL D01, D11, D81)
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Sun, Yi, Wen-Jia Zhang, Xin Zhao, Ren-Pei Yuan, Hui Jiang et Xiao-Ping Pu. « PARK7 protein translocating into spermatozoa mitochondria in Chinese asthenozoospermia ». REPRODUCTION 148, no 3 (septembre 2014) : 249–57. http://dx.doi.org/10.1530/rep-14-0222.

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PARK7 (DJ1) is a multifunctional oxidative stress response protein that protects cells against reactive oxygen species (ROS) and mitochondrial damage. PARK7 defects are known to cause various physiological dysfunctions, including infertility. Asthenozoospermia (AS), i.e. low-motile spermatozoa in the ejaculate, is a common cause of human male infertility. In this study, we found that downregulation of PARK7 resulted in increased levels of lipid peroxide and ROS, decreased mitochondrial membrane potential, and reduced mitochondrial complex I enzyme activity in the spermatozoa from AS patients. Furthermore, it was observed that PARK7 was translocated into the mitochondria of damaged spermatozoa in AS. Finally, we examined the oxidative state of PARK7 and the results demonstrated the enhancement of oxidation, expressed by increased sulfonic acid residues, the highest form of oxidation, as the sperm motility decreased. Taken together, these results revealed that PARK7 deficiency may increase the oxidative stress damage to spermatozoa. Our present findings open new avenues of therapeutic intervention targeting PARK7 for the treatment of AS.
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Denti, Tommaso. « Posterior Separable Cost of Information ». American Economic Review 112, no 10 (1 octobre 2022) : 3215–59. http://dx.doi.org/10.1257/aer.20211252.

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We provide testable conditions under which the cost of acquiring information is given by the expected reduction of a measure of uncertainty (e.g., entropy). The assumption, under the name of posterior separability, is nearly universal in the literature of rational inattention; yet, a testable characterization has been lacking. In applications to experimental data, we indicate situations in which posterior separability is—and is not—a compelling assumption for the cost of information; we propose a generalization to address some of its shortcomings. We also show how to identify and estimate nonparametrically the cost of information from observable choice behavior. (JEL C91, D11, D12, D81, D91)
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Frick, Mira, Ryota Iijima et Yuhta Ishii. « Dispersed Behavior and Perceptions in Assortative Societies ». American Economic Review 112, no 9 (1 septembre 2022) : 3063–105. http://dx.doi.org/10.1257/aer.20190486.

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We formulate a model of social interactions and misinferences by agents who neglect assortativity in their society, mistakenly believing that they interact with a representative sample of the population. A key component of our approach is the interplay between this bias and agents’ strategic incentives. We highlight a mechanism through which assortativity neglect, combined with strategic complementarities in agents’ behavior, drives up action dispersion in society (e.g., socioeconomic disparities in education investment). We also suggest that the combination of assortativity neglect and strategic incentives may be relevant in understanding empirically documented misperceptions of income inequality and political attitude polarization. (JEL C78, D11, D31, D72, D82, D91)
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Brüggemann, Bettina. « Higher Taxes at the Top : The Role of Entrepreneurs ». American Economic Journal : Macroeconomics 13, no 3 (1 juillet 2021) : 1–36. http://dx.doi.org/10.1257/mac.20170441.

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This paper computes optimal top marginal tax rates in Bewley-Huggett-Aiyagari–type economies that include entrepreneurs. Consistent with the data, entrepreneurs are overrepresented at the top of the income distribution and are thus disproportionately affected by an increase in the top marginal income tax rate. The top marginal tax rate that maximizes welfare is 60 percent. While average welfare gains are positive and similar across occupations along the transition, they are larger for entrepreneurs than for workers in the long run, and this occupational gap in welfare gains after the tax increase widens with increasing income. (JEL D11, D21, D31, H21, H24, L26)
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Robson, Arthur J., et Balázs Szentes. « A Biological Theory of Social Discounting ». American Economic Review 104, no 11 (1 novembre 2014) : 3481–97. http://dx.doi.org/10.1257/aer.104.11.3481.

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We consider a growth model in which intergenerational transfers are made via stocks of private and public capital. Private capital is the outcome of individuals' private savings while decisions regarding public capital are made collectively. We hypothesize that private saving choices evolve through individual selection while public saving decisions are the result of group selection. The main result of the paper is that the equilibrium rate of return to private capital is at least 2–3 percent more than the rate of return to public capital. In other words, social choices involving intertemporal trade-offs exhibit much more patience than individual choices do. (JEL D11, D71, D91, H43)
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Lizzeri, Alessandro, et Leeat Yariv. « Collective Self-Control ». American Economic Journal : Microeconomics 9, no 3 (1 août 2017) : 213–44. http://dx.doi.org/10.1257/mic.20150325.

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Behavioral economics presents a “paternalistic” rationale for a benevolent government's intervention. We consider an economy where the only “distortion” is agents' time-inconsistency. We study the desirability of various forms of collective action, ones pertaining to costly commitment and ones pertaining to the timing of consumption, when government decisions respond to voters' preferences via the political process. Three messages emerge. First, welfare is highest under either full centralization or laissez-faire. Second, introducing collective action only on consumption decisions yields no commitment. Last, individuals' relative preferences for commitment may reverse depending on whether future consumption decisions are centralized or not. (JEL D03, D11, D61, D72, D91)
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Bilsland, Alan E., Yu Liu, Andrew Turnbull, David Sumpton, Katrina Stevenson, Claire J. Cairney, Susan M. Boyd, Jon Roffey, David Jenkinson et W. Nicol Keith. « A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation ». Neoplasia 21, no 9 (septembre 2019) : 893–907. http://dx.doi.org/10.1016/j.neo.2019.07.008.

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Ishibashi, Matsujiro, Yuka Ouchiyama, Yukiko Inoue, Ayaka Iwashita, Yuri Sengan, Michio Onjo et Masao Tokunaga. « [Regular Paper] Cloning, Expression and Purification in Escherichia coli of DJ1 Protein from Dioscorea japonica Thunb. » Bulletin of Applied Glycoscience 4, no 3 (2014) : 241–48. http://dx.doi.org/10.5458/bag.4.3_241.

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