Thèses sur le sujet « Disordered Potential »
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McDowell, Chester Dale. « Potential heterogeneity in p53/S100B(ββ) complex ». Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/13845.
Texte intégralDepartment of Biochemistry
Jianhan Chen
Paul E. Smith
Intrinsically disordered proteins have been shown to be important in many physiological processes, including cell signaling, translation, and transcription. They are also associated with cancer, and neurodegenerative diseases. The tumor suppressor p53 contains several disordered regions, including the C-terminal negative regulatory domain (NRD). In cancer the function of p53 has been shown to be repressed by S100B(ββ) binding to p53-NRD. Binding of S100B(ββ) blocks acetylation and phosphorylation sites in the p53-NRD, which leads to tetramer dissociation and prevents p53 activation. NMR studies have shown that p53-NRD binds S100B(ββ) in a stable α-helix conformation. Interestingly, despite the well-converged and apparent rigid nature of the NMR structure ensemble, a majority of intermolecular NOEs used to calculate the NMR ensemble are very weak (≥6 Å). The final NMR structures also contains unsatisfied buried charged residues at the binding interface. It’s plausible that the p53-S100B(ββ) complex is more dynamic than previously believed. The goal of the study is to determine the potential conformational heterogeneity in p53-S100B(ββ) complex using molecular modeling. For this, five diverse structures were selected from the 40-member NMR ensemble. For each initial conformation, we performed 100 ns molecular dynamic simulations in explicit solvent to explore the structure and dynamics of the p53-NRD in complex with S100B(ββ). Several analytical tools were used to characterize the p53-NRD conformation, including root-mean squared deviation (RMSD), root-mean squared fluctuation (RMSF), and residue helicity. The accuracy of the simulations was mainly assessed by comparing with experimental NOEs. The results show that, even though the ensemble is heterogeneous it satisfies 82% of the experimental NOEs. Clustering analysis further suggests that many conformational sub-states coexist for this complex, and individual clusters appear to satisfy only subsets of NOE distances. Importantly, the buried surface analysis demonstrates that the heterogeneous ensemble generated from MD provides similar shielding of key residues, which include post-translational modification residues needed for p53 activation. This study also demonstrates that atomistic simulations can provide important insights into structure and dynamics of IDPs for understanding their biological function.
Mukhtar, Musawwadah. « State-dependent disordered potential for studies of Anderson transition with ultracold atoms ». Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLO001/document.
Texte intégralIn this manuscript, we present our progress towards realizing a spectroscopic method to study of Anderson transition with ultracold atoms. This relies on the realization of state-dependent disordered potential whereby the disorder is significant only for one of two involved spin-states. Combined with technique of radio-frequency transfer from the disorder-free state to the state with controlled disorder, it becomes possible to load a matter wave in the disorder in a well-defined energy states. As a proof of principle, we have performed measurements of the spectral functions of ultracold atoms in disordered potentials, which are directly proportional to the transfer rate of the atoms. We present the results showing excellent agreement with numerical calculations. This has opened up prospects for further studies of the Anderson transition. In particular we seek to observe transition between the diffusive and the localized states separated by a critical energy, the so-called mobility edge. Such study requires realization of state-dependent disorder which allows long propagation time in the disorder in order to distinguish the two phases. For this purpose, we present a new scheme of the state-dependent disorder with two laser speckles (bichromatic laser speckle). This paves the way towards spectroscopic approach of Anderson transition with ultracold atoms with energy resolution much higher than those in the previous experiments
Felix, Moscoso Monica, Galvan Jack Denegri, Loayza Fernando Ortega et Adrian V. Hernandez. « Respiratory Therapy in Chronic Heart Failure Patients Complicated With Sleep-Disordered Breathing : Potential Study Bias ». Journal of the Japanese Circulation Society, 2016. http://hdl.handle.net/10757/611825.
Texte intégralCadel, Agnese. « Disordered models : Spin Glasses and Directed Polymers ». Doctoral thesis, Università degli studi di Padova, 2008. http://hdl.handle.net/11577/3425541.
Texte intégralLi, Yuting. « Simulations and Electronic Structure of Disordered Silicon and Carbon Materials ». Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1395410498.
Texte intégralLellouch, Samuel. « Collective localization transitions in interacting disordered and quasiperiodic Bose superfluids ». Thesis, Palaiseau, Institut d'optique théorique et appliquée, 2014. http://www.theses.fr/2014IOTA0017/document.
Texte intégralIn this thesis, we theoretically investigate the collective localization properties of weakly-Interacting Bose superfluids subjected to disordered or quasiperiodic potentials. While disorder has been recognized since Anderson to induce single-Particle localization, the interplay between disorder and interactions in quantum systems is today among the most challenging questions in the field, and underlies fascinating phase transitions and non-Trivial localization effetcs. Focusing on Bose gases in the weakly-Interacting regime for which the Bogoliubov theory proves a successful tool, we study the localization transitions of collective excitations in several contexts. First, in the case of a continuous true disorder, we develop a strong-Disorder formalism going beyond previous studies, providing us with a complete description of the localization behaviour of collective excitations in arbitrary dimension. A generic localization diagram is obtained and the transport of excitations in the disorder is microscopically interpreted. Secondly, we consider the case of one-Dimensional quasiperiodic potentials, which are known to display intermediate properties between periodic and disordered ones. We perform a numerical and analytical treatment of the localization problem of collective excitations, allowing us to quantitatively characterize and interpret the localization transition in terms of an effective multiharmonic problem. Finally, we set up the general inhomogeneous formalism to address such issues in multicomponent Bose gases, and enlighten the basic physic of such systems, which are known to exhibit their own specific features
Schwabe, Nikolai F. « Weighted two-particle Green's functions in the coherent-potential approximation and perturbation effects in tunneling systems out of equilibrium ». Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318916.
Texte intégralLaubie, Hadrien Hyacinthe. « Elastic properties and failure behavior of disordered porous solids : a potential-of-mean-force-based lattice element approach ». Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111443.
Texte intégralCataloged from PDF version of thesis.
Includes bibliographical references (pages 165-175).
The effective mechanical properties of multiphase materials not only depend on the volume fraction and chemical composition of their constituents but also on details of their local texture. Yet, most homogenization methods do not take this texture effect into account. Understanding how local texture affects the overall elastic and failure properties of heterogeneous solids is the focus of this thesis. Emphasis is placed on porous media that are critical for many industry sectors, that either aim at engineering the porosity and its distribution in synthesized materials to reach desired properties; or at predicting the behavior of naturally-occurring porous materials given porosity and porosity fluctuations. To this end, a discrete simulation tool -coined lattice element method (LEM)- was implemented. Akin to potential-of-mean-force approaches used in soft-matter physics, a solid structure is discretized into mass points interacting with the nearest neighbors through effective interaction potentials. Depending on the choice of the local interactions, a phase's effective behavior can be linear or non-linear; isotropic or anisotropic. Introducing two different failure criteria, the fracture behavior is shown to be in perfect agreement with classical theories. A detailed LEM calibration procedure is provided. By means of extensive simulations, the role of textural properties on the mechanical behavior of random porous materials is investigated. Starting from an ordered configuration, it is found that a gradual increase in disorder can considerably deteriorate both stiffness and failure resistance of disordered porous solids. Specifically, it is shown that this disorder-induced strength and stiffness degradation results from a transition from a state governed by a single-pore stress concentration to a state controlled by multi-pore interactions, with the tail length of stress distribution being correlated with disorder. We propose that classical homogenization methods based on first or second-order averaging methods are amended to consider the found higher-order stress-distribution characteristics for highly disordered porous materials.
by Hadrien Laubie.
Ph. D. in Mechanics of Materials
Lang, Brittany. « A Longitudinal Exploration of Drive for Leanness : Potential Uniqueness, Sex Neutrality, Adaptive Nature, and Sociocultural Fit ». Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7537.
Texte intégralRowlands, Derwyn Andrew. « The Korringa-Kohn-Rostoker nonlocal coherent-potential approximation : a new method for calculating the electronic structure of disordered metallic systems ». Thesis, University of Warwick, 2004. http://wrap.warwick.ac.uk/59515/.
Texte intégralIceta, Sylvain. « Repenser la désinhibition alimentaire dans l’obésité, sous l’angle de l’hypothèse de l’addiction à l’alimentation ». Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1003/document.
Texte intégralFood addiction (FA) is an old concept, but still subject to controversy. It affects 18 to 24% of obese people. In this thesis, we are interested in overlaps between food behavior regulation, addiction and FA, in order to better understand the mechanisms linked to food intake disinhibition. Our work leads to several results: 1) A review of the literature has shown the existence of close interaction between eating behavior regulation levels and how FA could be an example of their disturbance. 2) A cohort study demonstrated the existence of common clinical features between addiction and FA and a probable addiction transfer from nicotine to food. 3) From an experimental point of view, we have shown that there are disturbances of P300 and N200 ERP, in obesity and food disinhibition, close to those observed in addictions. 4) Finally, our results suggest the potential role of ghrelin as a marker for eating disorders increased risk. This work opens experimental perspectives, with the suggestion of more relevant control groups; clinical perspectives, with the creation of a screening tool; therapeutics perspectives, with the establishment of a therapeutic trial by tDCS
Gulenko, Anastasia. « Etude structurale du verre de TeO₂ et de la variété désordonnée TeO₂-δ par dynamique moléculaire ». Thesis, Limoges, 2014. http://www.theses.fr/2014LIMO0013/document.
Texte intégralThis work aims to improve the structural description of the pure TeO2 glass and to give a deep insight into the structure of the disordered δ-TeO2 phase by means of molecular dynamics (MD) simulations.We derived simple but nontrivial interatomic potentials (IAPs), which take into account the polarisability of tellurium and oxygen atoms using the core-shell model. We demonstrated the important role of the electronic lone pair of the tellurium atoms in the formation of asymmetrical TeOx units. The accurate IAPs is able to reproduce 17 crystalline TeO2-based structures and are appropriate for MD simulations of disordered systems.The MD simulations of the pure glass and δ-TeO2 phase structures were carried out. It was demonstrated that the TeO2-glass consists of mainly TeO3 and TeO4 structural units and a large number of non-bridging oxygen (NBO) atoms is observed. The coordination number of the tellurium atoms in the glass is less than in the pure crystalline structures.In the δ-TeO2 phase, the tellurium atoms form a well-defined crystalline (FCC) lattice and the oxygen atoms exhibit a large positional disorder. This phase has a structural units distribution and a tellurium coordination number and a proportion of NBO atoms similar to those of the glass. Hence, the structure of δ-TeO2 is closer to that of glass than to the structures of other pure TeO2 crystalline polymorphs
Jendrzejewski, Fred. « Quantum transport of ultracold atoms in disordered potentials ». Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00809290.
Texte intégralKuhn, Robert. « Coherent transport of matter waves in disordered optical potentials ». [S.l.] : [s.n.], 2007. http://opus.ub.uni-bayreuth.de/volltexte/2007/287.
Texte intégralKiang, Michael Wai Jong. « Event-rated brain potential studies of semantic processing in schizophrenia and schizotypal personality ». Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3283453.
Texte intégralTitle from first page of PDF file (viewed November 7, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Farrow, Maree J., et maree farrow@med monash edu au. « Brain electrical activity topography in attention-deficit/hyperactivity disorder ». Swinburne University of Technology, 2003. http://adt.lib.swin.edu.au./public/adt-VSWT20050406.141958.
Texte intégralPISANÒ, CLARISSA ANNA. « Therapeutic potential of RGS4 blockade in movement disorders ». Doctoral thesis, Università degli studi di Ferrara, 2020. http://hdl.handle.net/11392/2478812.
Texte intégralRegulators of G-protein signaling (RGS) are a class of protein which negatively modulate the intracellular pathways evoked by G-proteins. RGS proteins bind the Gα subunit of the heterotrimer G-protein and accelerate the hydrolysis of GTP, turning the GPCR (G-protein coupled receptor) signal off. Targeting an RGS protein could potentiate the activity of an endogenous or exogenous agonist, improving its selectivity or tissue-specificity. RGS4 is the most studied among RGS proteins. It is mostly expressed in brain areas, such as cortex and basal ganglia (BG). The involvement of RGS4 in various pathological conditions, such as schizophrenia, Parkinson’s disease (PD) and L-Dopa induced dyskinesia (LID) has been proven. This thesis adds to these findings, providing evidence of an involvement of RGS4 in neuroleptic-induced parkinsonism (Study I) and disclosing for the first time an RGS4-NOP receptor interaction which can be targeted in LID therapy (Study II). In Study I, the ability of two RGS4 inhibitors in reversing raclopride-induced akinesia was investigated. Dual probe microdialysis was used to monitor in vivo glutamate release in the substantia nigra reticulata to assess whether these inhibitors impact the activity of the indirect pathway and to identify their site of action. Biochemical signatures of D2 signalling pathway activation following RGS4 inhibition were studied. A preliminary attempt to identify the GPCR targeted by RGS4 was made by challenging RGS4 inhibitors with an mGlu5 receptor antagonist. The main findings were that both RGS inhibitors attenuate neuroleptic-induced parkinsonism, acting at the striatal and nigral levels to attenuate the neuroleptic-induced disinhibition of the indirect pathway. At the striatal level, RGS4 inhibition potentiated the neuroleptic-induced activation of MAPK pathway and did not involve mGlu5 receptors. LID is a cluster of abnormal involuntary movements (AIMs), caused by chronic administration of L-Dopa, which represent the most disabling complication of dopamine replacement therapy of PD. In Study II, an attempt was made to widen the therapeutic window of a NOP receptor agonist by leveraging the RGS4-NOP receptor interaction. The interaction of RGS4 with the NOP receptor was first demonstrated in a cell model, then in striatal slices. Biochemical readouts of NOP activity were the D1 receptor-stimulated cAMP accumulation in cell lines, and the D1 receptor-stimulated number of pERK-positive neurons in slices. The impact of the RGS4 inhibitor CCG-203920 on the antidyskinetic effect of the Nociceptin/orphanin FQ (N/OFQ) opioid peptide (NOP) receptor agonist AT-403 was then evaluated in a rat model of LID. The ability of CCG-203920 to potentiate the antidyskinetic effect relative to the sedative effect of AT-403 was assessed, and the interference of CCG-2003920 with the molecular pathways underlying LID was evaluated using Western analysis of pERK and pGluR1 levels. Finally, Western analysis was also used to monitor levels of RGS4 in the striatum following dopamine-depletion and chronic L-Dopa treatment. The main findings of Study II were the demonstration that RGS4 negatively modulates NOP receptor function, and that RGS4 inhibition potentiates the antidyskinetic effect of the NOP receptor agonist without amplifying its sedative effects. RGS4 inhibition might also be useful to correct the upregulation of RGS4 levels in striatum occurring during dyskinesia expression. In conclusion, these studies confirmed the involvement of RGS4 in basal ganglia dysfunction and the therapeutic potential of RGS4 inhibitors for treating neuroleptic-induced parkinsonism and LID. Targeting signaling molecules downstream of GPCRs, i.e. RGS proteins, can prove a novel tool to improve drug safety and clinical profile.
Taylor, Rachael Louise. « Vestibular Evoked Myogenic Potential Characteristics in Common Vestibular Disorders ». Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/15856.
Texte intégralBreitfeld, Jörg [Verfasser]. « Identification of Potential Biomarkers for Depressive Disorders / Jörg Breitfeld ». Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1149154330/34.
Texte intégralTaliaferro, Linda Kay. « Psychiatric Disorders as Potential Predictors in Medical Disease Development ». ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/939.
Texte intégralRogers, Dave Edward. « Event-related potentials in obsessive-compulsive disorder ». Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696168.
Texte intégralWilliams, Kimberley Clare. « Differences in visual attention processing : An event-related potential comparative analysis within psychotic disorders ». University of the Western Cape, 2019. http://hdl.handle.net/11394/6706.
Texte intégralINTRODUCTION: Sustained attention is known to be dysfunctional in psychotic disorders. Sustained attention is the ability to remain focused on a specific time-locked stimulus within a task. We aimed to determine whether there are specific group differences between CON and three psychotic disorders: SCZ, MPD and BPD, then to determine differences between these psychotic disorders. This included differences in behavioural performance and prominent electrophysiological event-related potential (ERP) wave components during cueing and target processing of a visual sustained attention task. Further we aimed to characterize ERP waveform component relationships across and within these groups for demographics, substance use, behavioural performance, and clinical variables, the last limited to the psychotic groups. Lastly, we investigated the effects of prescribed medications on ERP wave components within the psychotic groups. METHODOLOGY: 103 participants (29 schizophrenia (SCZ), 28 bipolar disorder with a history of psychosis (BPD), 21 methamphetamine-induced psychotic disorder (MPD), and 30 controls (CON)) underwent electroencephalography (EEG) record while completing a visual continuous performance task. Participants were presented with 60 trials with three consecutive S’s, the presentation of the third S required a behavioural response. Prominent ERP waveform components were extracted from cues and target stimulus. Group differences were determined by ANOVA with Bonferroni post-hoc correction or multivariate Kruskal-Wallis test dependent on data distribution. Relationships between ERP wave components were determined appropriate with Spearman’s Rank order correlation analyses. RESULTS: (1) MPD reported higher use of substances compared to CON, SCZ and BPD. SCZ behavioural performance was poorer compared to CON which was shown by their longer response times, reduced accuracy and increased errors of omission. Clinically, MPD was found to have a shorter duration of illness compared to SCZ. Then SCZ was found to have more positive symptoms compared to BPD whereas BPD had more negative symptoms compared to SCZ. For the first cue, wave component differences were found only over the left hemisphere, for P100 amplitude over the frontal cortex, P300 amplitude over the central cortex, and N170 amplitude over the parietal cortex. For the presentation of the second cue, differences noted for all groups were localised to the frontal and central brain regions, for P100 and N170 ERP waveforms. For the target stimulus wave component differences were found over the prefrontal, frontal and parietal brain regions, within CON, SCZ, BPD and MPD. (2) For the first cue, education positively correlated with the N170 left parietal amplitude in CON and P300 right parietal amplitude in MPD. During the second cue, the left parietal N170 latency in SCZ correlated positively with education and the left central P300 latency correlated negatively with education in MPD. The age on the day of testing correlated positively with the target left frontal P300 latency in MPD. For the first cue, substance use positively correlated with the left and right parietal P300 latency and negatively for the right parietal P100 amplitude in SCZ. In MPD, a negative correlation was noted across left and right prefrontal N170 and P300 amplitudes, and positive correlation for the left prefrontal P300 latency in MPD. For the target stimulus, correlations were evident for the left and right parietal N70, N170 amplitudes, P300 latency, the right parietal P100 amplitude and left central P300 latency in SCZ. For the first cue, in SCZ PANSS total score correlated positively with left and right central P300 amplitudes and the left parietal P300 amplitude. For the second cue; in MPD, the PANSS negative symptom score, positively correlated with the P100 and N170 left parietal amplitude, left and right parietal P150 amplitude, left central and right parietal P300 amplitude. For the target, the Hamilton depression rating scale correlated positively with the left and right frontal P300 amplitude in MPD and then negatively with the right parietal P300 amplitude in SCZ. Behavioural performance in CON, positively correlated with the left parietal N70, P100, P150 and N170 amplitude the number of correct responses, and left central N170 amplitude. While the number of impulsive responses correlated negatively with the left parietal N70, P100, P150 and N170 and the left central N170 amplitude of CON. For the second cue, behavioural performance was related to the fronto-parietal relationship across all groups. For the target stimulus, impulsive responses positively correlated with the left parietal N70 latency in SCZ. Overall response time negatively correlated with the right parietal P300 latency for SCZ. (3) Medication was found to affect ERP wave components during the sustained visual attention task. For the first cue FGA’s increased the left central P100 amplitude in both SCZ and BPD and decreased the left parietal P100 amplitude in SCZ only. The use of antipsychotics increased the right parietal N70 and left central P100 amplitudes in BPD, specifically the right prefrontal N170 amplitude was increased with the use of SGA’s. Then clozapine use increased the left frontal P100 amplitude in SCZ. For the second cue, SGA’s decreased the right parietal P150 amplitude in SCZ but in MPD the right parietal P150 amplitude was increased with haloperidol use, and FGA. SGA’s increased the left parietal P300 latency in BPD and sodium valproate decreased the left prefrontal P300 latency. For the target stimulus, SGA’s decreased the right parietal P100, P150 and left parietal P150 amplitudes and increased the left central P300 latency in BPD. CONCLUSION: (1) sustained attentional performance is poorer in SCZ. Our study adds to previous studies showing attention processing deficits in SCZ, are evident during cueing of a sustained attention tasks; (2) substance use was found to slow cognitive processing, education improved executive function and information processing, and symptom severity was associated with dysfunction of prefrontal and frontal cortices; (3) antipsychotic medication was related to improved processing of salient information. These data support the current literature and provide novel insights to the attentional processing deficits during cueing in the psychotic disorders.
Eisenbrandt, Lydia L., Alyssa P. Gretak, Brittany S. Sharma et Jill D. Stinson. « Externalizing Disorders as a Potential Risk Factor for Adolescent Males ». Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7883.
Texte intégralXiang, Ping. « Quantum control of dynamics of quasiparticles in periodic and disordered lattice potentials ». Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/49995.
Texte intégralScience, Faculty of
Chemistry, Department of
Graduate
Zoltowska, Katarzyna Marta. « Novel pathogenic mechanisms of myasthenic disorders and potential therapeutic approaches ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:e817f50a-0318-4944-bf67-773af523c4c3.
Texte intégralBerglof, Hollie K. « Differential Diagnosis of Attention Deficit Hyperactivity Disorder and Depression : Potential Bias and Misdiagnosis ». DigitalCommons@USU, 2003. https://digitalcommons.usu.edu/etd/6189.
Texte intégralMohamad, Zaini Zuraiza Binti. « Chromosomal instability in oral potentially malignant disorders ». Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/chromosomal-instability-in-oral-potentially-disorders(bc361088-778f-4089-94c5-86e277eede62).html.
Texte intégralRoberts, Leanne. « Cannabinoids as potential new therapeutics of gastrointestinal motility and inflammatory disorders ». Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/14092/.
Texte intégralDiSilvestro, David Joel. « Encapsulation of Genetically Modified Preadipocytes for Potential Treatment of Metabolic Disorders ». The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449090087.
Texte intégralBrown, Lecia Ashanna Moya. « The Potential Role of Antiretroviral Efavirenz in HIV Associated Neurocognitive Disorders ». Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6685.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1248530.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263904.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1264024.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263926.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1248550.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263964.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1263986.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1264046.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1265284.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1248611.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1265264.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1266688.
Texte intégralROCCHETTI, MATTEO. « AUTISM SPECTRUM DISORDERS IN ADULTS : CLINICAL DIAGNOSIS AND POTENTIAL SERUM BIOMARKER ». Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1265364.
Texte intégralSchulze, Katja Kristina. « Event-related potentials in bipolar disorder : a family study ». Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437286.
Texte intégralHarris, Gregory Glenn. « Potential role of social support systems and post traumatic stress disorder ». Huntington, WV : [Marshall University Libraries], 2005. http://www.marshall.edu/etd/descript.asp?ref=579.
Texte intégralMorgan, Charlie David. « Olfactory event-related potentials in Alzheimer's disease / ». Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9974114.
Texte intégralBoltz, Horst-Holger [Verfasser], Jan [Akademischer Betreuer] Kierfeld et Joachim [Gutachter] Stolze. « Semiflexible polymers in disordered potentials / Horst-Holger Boltz. Betreuer : Jan Kierfeld. Gutachter : Joachim Stolze ». Dortmund : Universitätsbibliothek Dortmund, 2016. http://d-nb.info/1112736662/34.
Texte intégralJoshi, Gururaj. « MULTIFUNCTIONAL POTENTIAL THERAPEUTICS TOWARDS OXIDATIVE STRESS MEDIATED NEURODEGENERATIVE DISORDERS AND MODELS THEREOF ». UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/298.
Texte intégralGray, James Andrew Russell. « Modulating the heat-shock response : a potential therapy for lysosomal storage disorders ». Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:d9b746c9-9026-4a6e-97b5-00bb848100d7.
Texte intégralScotto, Rosato Anna. « TRPML1 : role in autophagy and potential target to treat lysosomal storage disorders ». Thesis, Open University, 2018. http://oro.open.ac.uk/55296/.
Texte intégral