Littérature scientifique sur le sujet « Dihydrolactucin »
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Articles de revues sur le sujet "Dihydrolactucin"
Fronczek, Chris F., Marco L. Gomez-Barrios, Nikolaus H. Fischer et Frank R. Fronczek. « 11β,13-Dihydrolactucin-8-O-acetate hemihydrate ». Acta Crystallographica Section E Structure Reports Online 65, no 10 (30 septembre 2009) : o2564—o2565. http://dx.doi.org/10.1107/s160053680903829x.
Texte intégralShah, Shazia, Zulfiqar Ali, Abdul Malik, Ikhlas A. Khan et Sumayya Saied. « Sesquiterpene Lactones from Cichorium intybus ». Zeitschrift für Naturforschung B 66, no 7 (1 juillet 2011) : 729–32. http://dx.doi.org/10.1515/znb-2011-0714.
Texte intégralRuggieri, Francesca, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert et Nicolas Willand. « A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards ». Pharmaceuticals 16, no 5 (22 mai 2023) : 771. http://dx.doi.org/10.3390/ph16050771.
Texte intégralWeng, Hui, Luanying He, Jiakun Zheng, Qing Li, Xiuping Liu et Dongliang Wang. « Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans ». Nutrients 12, no 12 (28 novembre 2020) : 3675. http://dx.doi.org/10.3390/nu12123675.
Texte intégralKisiel, Wanda. « Sesquiterpene lactones from Picris pauciflora Willd. » Acta Societatis Botanicorum Poloniae 64, no 2 (2014) : 159–61. http://dx.doi.org/10.5586/asbp.1995.021.
Texte intégralHANCE, P., Y. MARTIN, J. VASSEUR, J. HILBERT et F. TROTIN. « Quantification of chicory root bitterness by an ELISA for 11β,13-dihydrolactucin ». Food Chemistry 105, no 2 (2007) : 742–48. http://dx.doi.org/10.1016/j.foodchem.2007.01.029.
Texte intégralMatos, Melanie S., José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall et al. « Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory ». Nutrients 12, no 11 (19 novembre 2020) : 3547. http://dx.doi.org/10.3390/nu12113547.
Texte intégralIlgün, Selen, Esra Küpeli Akkol, Mert Ilhan, Derya Çiçek Polat, Ayse Baldemir Kılıç, Maksut Coşkun et Eduardo Sobarzo-Sánchez. « Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey ». Molecules 25, no 7 (30 mars 2020) : 1587. http://dx.doi.org/10.3390/molecules25071587.
Texte intégralZheleva-Dimitrova, Dimitrina, Alexandra Petrova, Gokhan Zengin, Kouadio Ibrahime Sinan, Vessela Balabanova, Olivier Joubert, Christian Zidorn, Yulian Voynikov, Rumyana Simeonova et Reneta Gevrenova. « Metabolite profiling and bioactivity of Cicerbita alpina (L.) Wallr. (Asteraceae, Cichorieae) ». Plants 12, no 5 (23 février 2023) : 1009. http://dx.doi.org/10.3390/plants12051009.
Texte intégralLang, Roman, Tatjana Lang, Andreas Dunkel, Florian Ziegler et Maik Behrens. « Overlapping activation pattern of bitter taste receptors affect sensory adaptation and food perception ». Frontiers in Nutrition 9 (19 décembre 2022). http://dx.doi.org/10.3389/fnut.2022.1082698.
Texte intégralThèses sur le sujet "Dihydrolactucin"
Ruggieri, Francesca. « Putting nature back into drug discovery : selection, design and synthesis of bioinspired chemical libraries for the discovery of new antibacterials ». Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS013.
Texte intégralNatural products (NPs) have declined in popularity since the introduction of synthetic small molecules several years ago. Many are the reasons behind this choice, such as difficulties in access and supply, complexities of NP chemistry and the advent of combinatorial chemistry. However, NPs offer many interesting properties compared to conventional synthetic molecules, which confer both advantages and challenges for the drug discovery process. Usually, NPs are characterized by a higher number of sp3 carbons and stereogenic centres, large scaffold diversity and structural complexity. With half of the drugs approved by the FDA since 1994 being NPs or hemisynthetic derivatives and the recent stagnation in new drug research and development, it is becoming more and more evident that NPs should be reintroduced in the drug discovery process as a source of inspiration.Therefore, many strategies are now emerging for the construction of nature-inspired chemical libraries, such as “top-down” and “bottom-up” strategies. In “bottom-up” approaches, complexity is created starting from simple building blocks. On the other hand, “top-down” approaches are assumed to make structural modifications to an already complex NP.Our presented work describes two different approaches to enrich the chemical library of our research unit with NP-derived compounds. A “top-down” semisynthetic strategy was planned to obtain derivatives of lactucin and 11β,13-dihydrolactucin, two sesquiterpene lactones extracted from chicory roots. Thirty-six ester derivatives were synthesized in three steps (classical synthesis), together with two amine derivative libraries (using parallel synthesis). All the compounds were then tested against Mycobacterium tuberculosis and some promising hits were found (MICGFP < 1.2 μM). On the other hand, a “bottom-up” strategy allowed the synthesis of two analogues of the known natural antibiotic hygromycin A. This approach started from simple commercially available building blocks and employed a dearomatization strategy in the synthetic process.Together, we explored a broader chemical space, increased the structural diversity of our chemical library and discovered new potential antibacterial hits. Moreover, this work paves the way for the discovery of new antibacterial targets