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Abu, Alabbas Belal. « Between scripture and human reason : an intellectual biography of Muḥammad ibn Ismā'īl al-Bukhārī (d.256/870) ». Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:e4ee70d8-9b60-4982-b382-4a96cd6f0553.
Texte intégralBarouni, Ahmad Yousef. « A critical study and edition of the manuscript of al-Du'afa' (weak narrators) of Muḥammad ibn Ismāʻīl Bukhārī (d. 256 AH/869 CE) ». Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25227.
Texte intégralBarouni, Ahmad Yousef. « A critical study and edition of the manuscript of al-Du’afa’ (weak narrators) of Muḥammad ibn Ismāʻīl Bukhārī (d. 256 AH/869 CE) ». Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25227.
Texte intégralBalagura, V., I. Adachi, H. Aihara, K. Arinstein, V. Aulchenko, T. Aushev, A. M. Bakich et al. « Observation of D_s1(2536)^+ → D^+π^-K^+ and angular decomposition of D_s1(2536)^+ →D^*+K_S^0 ». American Physical Society, 2008. http://hdl.handle.net/2237/11346.
Texte intégralPinheiro, Tânia Marisa Macedo. « A importância clínica da vitamina D ». Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5301.
Texte intégralNos últimos anos, o papel fisiológico da vitamina D tem sido amplamente estudado. A sua ação primordial no metabolismo do cálcio é já bem conhecida, sendo esta uma das hormonas responsáveis pela manutenção dos níveis de cálcio sérico, através da promoção da absorção de cálcio e fósforo a partir do intestino e da reabsorção óssea de cálcio. No entanto, o interesse clínico na vitamina D não se restringe apenas ao metabolismo fosfocálcio, mas também se manifesta em várias outras condições médicas (diabetes, doenças cardiovasculares, esclerose múltipla, câncer, distúrbios psiquiátricos, doenças neuro-muscular). De facto, evidências recentes correlacionam níveis insuficientes de vitamina D, com um risco aumentado de desenvolvimento de outras doenças, não relacionadas com a componente óssea. A elevada prevalência de níveis inadequados de vitamina D é hoje em dia encarada como um problema de saúde pública que afeta vários países da Europa e os EUA. Por este motivo, e pelo conhecimento do crescente número de doenças associadas a esta deficiência, a medição exata dos níveis de vitamina D tem assumido elevada relevância na clínica. Desta forma, o número de análises para avaliação da quantidade de vitamina D para fins de diagnóstico aumentou significativamente. A concentração de 25- hidroxivitamina D (25(OH)D) é o parâmetro de rotina, mas a determinação de outros metabolitos, em particular a forma fisiologicamente ativa 1,25 dihidroxivitamina D (1,25(OH)2D) pode ser também de interesse clínico. No entanto, os níveis séricos de 25(OH)D são o melhor indicador do conteúdo corporal de vitamina D, uma vez que reflete a quantidade obtida a partir da ingestão e exposição à luz solar, assim como da conversão de vitamina D a partir de depósitos de gordura no fígado. As últimas orientações da Endocrine Society sugerem o rastreio do défice de vitamina D apenas em indivíduos em risco e não na população em geral. Nestes doentes, recomenda-se a medição da 25(OH)D sérica circulante, por um método analítico fiável. Ao longo dos anos, técnicas de quantificação de 25(OH)D e a 1,25(OH)D têm aumentado e evoluído. Estes métodos são baseados em ensaios de ligação competitiva por meio de imunoensaio e cromatografia líquida associados com espectrometria de massa, no entanto estes têm demonstrado vários desafios analíticos, sendo que as vantagens e desvantagens de cada método mudam constantemente com novos desenvolvimentos tecnológicos. Os imunoensaios continuam a ser o modo predominante de medição para 25(OH)D, embora os problemas com a recuperação equimolar dos metabolitos D2 e D3 permanecem um problema. O défice de vitamina D é definido por um valor de 25(OH)D inferior a 20 ng/mL (50 nmol/L). Em indivíduos em risco recomenda-se a ingestão de vitamina D na dieta, de acordo com a idade e situações especiais (gravidez, amamentação, obesidade e toma concomitante de alguns fármacos). Para o tratamento e prevenção do défice de vitamina D sugere-se a utilização de qualquer das isoformas de vitamina D (o colecalciferol ou vitamina D3 e o ergocalciferol ou vitamina D2, em dose dependente do grupo etário e das necessidades específicas.
In recent years, the physiological role of vitamin D have been widely studied intensively. Its primary action on the calcium metabolism is well known, this being one of hormones responsible for the maintenance of serum levels of calcium, by promoting calcium and phosphorus absorption from the intestine and from bone calcium resorption. However, clinical interest in vitamin D is not restricted to the fosfocalcium metabolism but also is affects several other medical conditions (diabetes, cardiovascular disease, multiple sclerosis, cancer, psychiatric disorders, neuro-muscular disease). In fact, recent evidences correlates insufficient levels of vitamin D with an increased risk of developing other diseases, not related to bone component. The high prevalence of inadequate vitamin D levels is nowadays seen as a public health problem that affects several countries in Europe and the USA. For this reason, and the knowledge of the growing number of diseases associated with this deficiency, the exact measurement of vitamin D levels has assumed great relevance in the clinic practice. Thus, the number of assays to determine circulating vitamin D for diagnostic purposes has increased significantly. Circulating 25 hydroxyvitamin D (25 (OH)D) concentration is routinely used, but measurement of other metabolites, especially the physiologically active 1,25 dihydroxyvitamin D (1,25 (OH)2D), are of clinical value. However, serum levels of 25(OH)D are the best indicator of vitamin D body content, as it reflects the vitamin obtained from dietary intake and exposure to sunlight, as well as the conversion of vitamin D from fatty deposits in liver. The latest Endocrine Society guidelines suggest screening for vitamin D deficiency only in individuals at risk and not in the general population. In these patients, it is recommended the measurement of 25(OH)D circulating in serum, by a reliable analytical method. Over the years, the development of the methods to quantify 25(OH)D and 1,25 (OH)2D have increased and evolved. These method are based in competitive binding assays through to immunoassay and liquid chromatography aligned to mass spectrometry, however these have demonstrated various analytical challenges, the advantages and disadvantages of each method are constantly changing with new technological developments. Immunoassay remains the predominant mode of measurement for 25(OH)D although problems with equimolar recovery of the D2 and D3 metabolites remain an issue. The vitamin D deficiency is defined by a value of 25 (OH) D lower than 20 ng/mL (50 nmol/L). In individuals at risk, the intake of dietary vitamin D according to the age and special medical conditions is recommended (pregnancy, breastfeeding, obesity and concomitant intake of drugs). For treatment and prevention of vitamin D deficiency it is suggested the use of any of the isoforms (cholecalciferol or vitamin D3 and ergocalciferol or vitamin D2) in an age-dependent and individual dose.
Rondeau, Marc. « Dosage sanguin de la 25 hydroxyvitamine d chez 128 entrants d'un service de medecine generale et rhumatologie a nantes ». Nantes, 1988. http://www.theses.fr/1988NANT002M.
Texte intégralBörjesson, Emma. « Analys av 25-hydroxyvitamin D i primärvården ». Thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120406.
Texte intégralBakgrund: Intresset för vitamin D har ökat de senare åren. Det beror dels på att det finns många eventuella positiva effekter av vitamin D och dels på att många individer har brist på vitamin D. Nutidens människa spenderar mycket tid inomhus vilket leder till lägre nivåer av vitamin D. Personer som har utvandrat från ett soligt klimat till nordiskt klimat får ofta brist på grund av en mer pigmenterad hud som behöver större mängd UVB för att få en adekvat syntes av vitamin D. Syfte: Syftet med den här studien är att jämföra och utvärdera hur lika det patientnära instrumentet mini VIDAS mäter 25(OH)D total mot befintlig metod cobas e 602. Diskussion om analysen 25(OH)D total har en plats i primärvården ingår även i studien. Metod: Jämförelsen baserades på 39 st prover. Proven analyserades på cobas e 602 och mini VIDAS. Ett precisionsförsök gjordes. Externkontroller från DEQAS inkluderades även i studien. Resultaten har presenterats genom enkel linjär regressionsanalys, medelvärde, SD och CV. Resultat: Jämförelsen mellan cobas e 602 och mini VIDAS gav en förklaringsgrad på 81,43 %. mini VIDAS var närmst externkontrollernas målvärden. Slutsats: Det går inte att dra självklara slutsatser ifall mini VIDAS uppfyller kraven att införas i primärvården. Förklaringsgraden som är på 81,43 % bör vara minst 95 %. Däremot överensstämmer mini VIDAS med externkontrollerna bättre än cobas e 602. Det finns faktorer som tyder på att analysen 25(OH)D har en plats i primärvården med avseende på efterfrågan, användningsområde och antal individer med brist. Instrumentet är dessutom användarvänligt för ett primärvårdslaboratorium.
Wyatt, Candy. « Serum 25-hydroxyvitamin D concentration in relation to melanoma progress ». Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/62441/2/Candy_Wyatt_Thesis.pdf.
Texte intégralEisele, Susanne [Verfasser]. « Bildgebung koronarer Plaques mittels 256-Zeilen Multidetektor Computertomographie : Untersucher-Varianz bei der Plaquevolumetrie unter Verwendung einer semiautomatischen Plaqueerkennungs-Software / Susanne Eisele ». Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1030316376/34.
Texte intégralQuitzke, Marcus [Verfasser], et Gunnar [Akademischer Betreuer] Lund. « Detektionsgenauigkeit von Koronarplaques und Reproduzierbarkeit von Koronarplaquequantifizierungen mittels 256-Zeilen-Computertomographie unter Verwendung einer automatischen Koronarplaqueanalysesoftware / Marcus Quitzke. Betreuer : Gunnar Lund ». Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1074642473/34.
Texte intégralPatel, Shalini. « Demographic, Dietary, and Lifestyle Determinants of Vitamin D Status in the US Population : National Health and Nutrition Examination Survey, 2005-2006 ». Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/37.
Texte intégralEllfolk, Maria. « Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D ». Doctoral thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9412.
Texte intégralPeiris, Alan N., Beth A. Bailey, Todd Manning et Les N. Peiris. « Are 25-Hydroxyvitamin D Levels Adequately Monitors Following Evidence of Vitamin D Insufficiency in Veterans ? » Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/6308.
Texte intégralAsano, Lisa. « Vitamin D metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP ». 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225512.
Texte intégralRose, Stanley David. « Regulation of pituitary function by 1α,25-dihydroxyvitamin D₃ ». Thesis, Massachusetts Institute of Technology, 1985. http://hdl.handle.net/1721.1/95537.
Texte intégralMICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.
Vita.
Includes bibliographical references.
by Stanley David Rose.
Ph.D.
Bennett, Sarah. « 3-epi-25 hydroxyvitamin D : assay development and measurement ». Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695221.
Texte intégralKhan, Shanchita R. « Effect of sunlight exposure on 25-Hydroxyvitamin D concentration ». Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/115121/2/Shanchita%20Khan%20Thesis.pdf.
Texte intégralSouza, Emily Fonseca de. « A unificação da Síria e o jihād de Nūr ad-Dīn na crônica Kitāb al-Kāmil fi l-ta\'rīkh, de Ibn al-Athīr ». Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/8/8138/tde-25102016-115357/.
Texte intégralIn our dissertation, we study the extract of Ibn al-Athīr\'s chronicle, Kitāb al-Kāmil fi l-ta\'rīkh, reporting the years of Nūr ad-Dīn\'s governmet. Our research is divided into three parts. The first presents the author and his work, the chronicles origin and the composition, besides presenting the historiographical debate on the work. The second approachs the rhetoric genres of Aristotles Rhetoric and the use of two of these genres, epideictic and deliberative, at the construction of Ibn al-Athīr\'s discourse. The third discusses the definitions of jihād both at Coran and at muslims juridical treatises, indicating how our author uses them to legitimate Nūr ad-Dīn\'s action in order to elaborate him, through his discourse, as an example of ruler.
Bandzaitė, Virginija. « Vitamino D, kalcitonino ir parathormono kiekių kaita karvių kraujo serume bei reikšmė mineralinių medžiagų apykaitos procesams ». Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20051230_125132-51108.
Texte intégralMorris, Carolyn W. « The Relationship Between Serum 25-Hydroxyvitamin D, Vitamin D and Calcium Intake, and Adiposity in Infants ». Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/nutrition_theses/46.
Texte intégralMartineau, Bernadette. « Associations of Serum Vitamin D Concentrations with Dietary Patterns in US Children ». Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/33.
Texte intégralYener, Mahmut Akkaş Selami. « Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri / ». Isparta : SDÜ Tıp Fakültesi, 2005. http://tez.sdu.edu.tr/Tezler/TT00216.pdf.
Texte intégralMilone, Cristiana. « Association between Serum Vitamin D Concentrations and Depression in the US Population : National Health and Nutrition Examination Survey, 1988-1994 ». Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/nutrition_theses/5.
Texte intégralTommie, Jessica. « Serum Vitamin D Status and Breast Cancer Risk by Receptor Status : A Systematic Review ». University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945.
Texte intégralHuang, Alice. « Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & ; Protein Expression : Complex Extracellular Ca2+ Concentration Dependence ». Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20127.
Texte intégralBahner, Johannes [Verfasser]. « Quantifizierung der Aortenklappenöffnungsfläche in der 256-Zeilen Computertomographie : Ein Vergleich mit der transösophagealen Echokardiographie und dem Herzkatheter bei Patienten mit hochgradiger Aortenklappenstenose vor perkutanem Aortenklappenersatz / Johannes Bahner ». Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1028862334/34.
Texte intégralKohlhaus, Rebekka Katharina Verfasser], et Guido [Akademischer Betreuer] [Sauter. « Die Rolle von p53, Ki-67, HER2 und TRRAP beim duktalen Adenokarzinom des Pankreas : Eine Gewebe - Mikroarray - Untersuchung an 256 Tumoren / Rebekka Katharina Kohlhaus. Betreuer : Guido Sauter ». Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/102041832X/34.
Texte intégralPalaniswamy, S. (Saranya). « Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study ». Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219295.
Texte intégralTiivistelmä D-vitamiinin puutos, lihavuus ja lyhyt telomeerien pituus liittyvät mahdollisesti lisääntyneeseen riskiin sairastua metabolisiin sairauksiin sekä yleisemmin kuolleisuuteen. Eräs selitys tälle voi löytyä tulehdustekijöistä. Lihavuuden, liikunnan puutteen ja verinäytteenoton ajankohdan tiedetään vaikuttavan 25-hydroksi-D-vitamiinin [25(OH)D]-pitoisuuteen, mutta niiden yhteys D-vitamiinin isomuotoihin (D2, D3) on vielä huonosti tunnettu. Aiemmin ei ole selvitetty 25(OH)D:n, painoindeksin (BMI), tulehduksen ja leukosyyttien telomeerien pituuden (LTL) välisiä yhteyksiä, ja siksi näistä tarvitaan lisätutkimusta. Tutkimusaineistona oli Pohjois-Suomen 1966 syntymäkohortin, 31-vuoden seurantaan osallistuneet henkilöt (N=4,758). Tutkimuksessa keskityttiin 1) selvittämään D2- ja D3-vitamiinipitoisuuksien määrittäviä tekijöitä ja tunnistamaan D-vitamiinin puutteeseen liittyviä riskitekijöitä, 2) tutkimaan 25(OH)D-pitoisuuden ja BMI:n suhdetta LTL:n kanssa sekä testaamaan, onko suhde riippumaton tulehduksellisista tekijöistä ja 3) arvioimaan ilmeneekö BMI:n ja tulehdussytokiinien välinen yhteys 25(OH)D-pitoisuuden kautta. Tutkimus osoitti, että D2-isomuodon osuus oli 5 % ja D3:n osuus 95 % koko 25(OH)D-pitoisuudesta. Näitä isomuotoja määrittäviä tekijöitä tutkittaessa havaittiin, että vähäisellä auringonvalolle altistumisella on todennäköisesti yhteys lisääntyneeseen D2-pitoisuuteen, mutta alhaisempaan D3-pitoisuuteen. Suun kautta otettavien ehkäisypillereiden käytöllä oli yhteys molempien muotojen lisääntyneisiin pitoisuuksiin. Tutkimus vahvisti alhaisten D-vitamiinipitoisuuksien tunnetut riskitekijät: lyhyt altistus auringon valolle sekä fyysinen passiivisuus. 25(OH)D-pitoisuus ei ollut yhteydessä LTL:ään mutta tulehdus näytti osittain vaikuttavan BMI-LTL-assosiaatioon. Korkeampi 25(OH)D-pitoisuus yhdistyi matalampiin tulehdussytokiinipitoisuuksiin, kun taas matala 25(OH)D-pitoisuus muokkasi BMI:n ja biomarkkereiden välisisiä yhteyksiä, tosin heikosti. Yhteenvetona voidaan todeta, että tulokset tukevat tunnettujen riskitekijöiden merkitystä D-vitamiinin puutoksessa ja tuovat lisää tietoa eri isomuotoihin vaikuttavista tekijöistä. Tutkimus antaa myös uusia näkemyksiä D-vitamiinin roolista lihavuuteen liittyvässä matala-asteisessa tulehduksessa. D-vitamiinin vaikutuksien tarkempi tunteminen on merkityksellistä myös kansanterveyden kannalta
Marcondes, Natália Aydos. « Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística ». reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/115588.
Texte intégralIntroduction: Cystic fibrosis patients have a susceptibility to vitamin D deficiency due to nutrient malabsorption. Prevalence studies of hypovitaminosis D in patients with cystic fibrosis have highly variable results and there is no data about the non pediatric population in Brazil. Objectives: To evaluate the prevalence of hypovitaminosis D in non pediactric cystic fibrosis patients and the factors associated with serum 25-hydroxyvitamin D levels. Methods: Cross-sectional study. The study population was composed of patients older than 16 years accompanied in the Cystic Fibrosis Ambulatory of the Hospital de Clínicas de Porto Alegre. We evaluated the prevalence of vitamin D deficiency defined as 25-hydroxyvitamin D < 30 ng/mL, as suggested recently by the Cystic Fibrosis Foundation, and clinical and laboratory factors associated with its serum levels. Nutritional status and hospital admissions were evaluated. Data was collected from medical records and interviews with patient, blood was collected. Laboratory analisys were performed at Clinical Pathology Laboratory of the Hospital. Serum C-reactive protein, calcium, phosphate, magnesium, albumin, 25-hydroxyvitamin D (method: chemiluminescence), and parathyroid hormone levels (method: sandwich immunoassay to intact PTH) were measured. Lung function was evaluated by spirometry and clinical and chest radiographic scores were assessed. Statistical significance level was set at P<0.05. Results: Prevalence of hypovitaminosis D was 61.0 %, with serum 25-hydroxyvitamin D levels of 28,42±10,94 ng/mL. Patients with pancreatic insufficiency had a trend to have higher vitamin D levels. Sixteen patients had severe lung disease with FEV1% predicted below 40%. After multivariable analysis, body mass index and hospitalization in the last month remained significantly associated negatively with serum 25-hydroxivitamin D levels. Conclusions: The prevalence of hypovitaminosis D in the present study was inferior to previously related. Vitamin D insufficiency is still a problem in cystic fibrosis patients, even in those receiving supplementation.
Chen, Nancy Nannan. « The effect of vitamin D supplementation during pregnancy and lactation on maternal & ; infant 25-hydroxyvitamin D concentration ». Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44967.
Texte intégralBeyer, Sarah. « Effekten av vitamin D2 vs. D3 på 25(OH)D-statusen : En litteraturstudie ». Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-76417.
Texte intégralBackground: Vitamin D comes in two different forms, D3 from animals (cholecalciferol) and D2 from plants (ergocalciferol). There has been different opinions among physicians and the general public about which of the calciferols is more potent to raise 25(OH)D-levels in the blood, which is the value that is measured to determine the vitamin D-status in the body. Since vitamin D deficiency is common among the people of the Nordic countries it is important to know which form has the best effect and should be used to treat and prevent vitamin D deficiency. Furthermore, it is relevant for vegans who do not eat the animalic D3, where recommendations might have to be changed. Aim: The aim of the study was to find out if there were differences in potency of D2 vs. D3 to raise 25(OH)D status in the blood and if so, to find possible explanations for those differences. Methods: Six relevant original articles that examined the effect of D2 vs. D3 on 25(OH)D status in the blood, were found in the database PubMed. The studies where published between the years 2008 and 2017. The participants were healthy adults. Results: Four of the studies suggested that D3 is more effective than D2 in order to raise the 25(OH)D status. One study concluded that there is no difference in the effectiveness of D2 vs D3 and one study showed that D2 is more effective than D3 when it comes to daily treatment but that D3 has a better effect than D2 when treatment happens on a two or four weekly basis with large doses. Conclusion: Most of the articles suggested a better effectiveness of D3 than D2 to raise 25(OH)D levels in the blood. However, besides the mixed results, the number of studies and participants was too small to come to a clear conclusion.
Omoike, Gracious. « Har D-vitamintillskott effekt vid behandling av Systemisk Lupus Erythematosus ? : En litteraturstudie ». Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-85942.
Texte intégralBackground: Systemic Lupus Erythematosus is a prototypical autoimmune disease in which antibodies attack healthy tissues in the body, causing inflammation in several organs. Aim: The aim of this literature study was to investigate the effect of Vitamin Dsupplementation on SLE. Method: The articles were searched in the database called ”Pubmed” using the search terms ”Systemic Lupus Erythematosus and Vitamin D supplementation”. Six of the articles which examined the effects of D-vitamin supplementation on SLE were relevant for this study. Result: More than half of the patients in all six studies reached sufficient serum 25(OH)D. Vitamin D-supplement reduced Th1/Th17-cells but increased Tregs-cells and Th2-cells. 3 studies showed a decrease in disease-activity and anti-dsDNA. C3 decreased in study 2. Discussion: Five studies indicated that the oral administration of vitamin-D supplementation had a positive effect on SLE. Two of the examined studies did not observe any clinical effect of the vitamin-D supplement. Conclusion: Vitamin-D supplement suppresses the immunesystem by increasing Treg cells and Th-2 cells but also reducing Th1/Th17-cells and B-cells as well as the production of autoantibodies and anti-dsDNA antibodies. The effect of vitamin D-supplement is unclear. More studies with more participants are required to determine if vitamin-D supplement can be used as a treatment for SLE.
Velarde, Laos Edmundo. « Fatty acid and lipid chemistry / F. D. Gunstone. London : Chapman and Hall, 1996. 252 p ». Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/99752.
Texte intégralMarsura, Lucia <1996>. « La disclosure sul capitale intellettuale nella Relazione sulla gestione dopo il D. Lgs. 254/2016 ». Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/18074.
Texte intégralGuenther, Isabel. « The relationship between serum leptin, 25-hydroxyvitamin D₃, and body composition ». Connect to this title, 2008. http://scholarworks.umass.edu/theses/196/.
Texte intégralHerdick, Michaela. « Modulation der Interaktion von Vitamin D3-Rezeptor-Komplexen mit Kernproteinen durch 1[alpha],25(OH)2D3 [1 alpha,25(OH) 2 D 3] und 1[alpha],25(OH)2D3-Analoge [1 alpha,25(OH) 2 D 3-Analoge] ». [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960407987.
Texte intégralBella, Leonardo Mendes. « Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus ». Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/.
Texte intégralDiabetes mellitus (DM) is a disease with high prevalence and morbidity worldwide, and the DM1 is responsible for 5-10% of cases. The vitamin D hormone pleiotropic action, can improve the course of T1DM, although the mechanisms are not fully elucidated. Thus, better understanding the action of this hormone can aid in prognosis as well as in understanding the possible mechanisms involved in the prevention of diabetes. We evaluated the physiological effects of vitamin D (800 IU/day/seven days, v.o.) in male mice (n=31, C57BL/6 strain) divided into four groups: Control + Water (CW, n=9); Control Vitamin D + (CV n=9); Diabetic + Water (DW, n=6) Diabetic + Vitamin D (VD, n=7). The mice induced-diabetes by alloxan (60 mg/kg, i.v.), when compared to controls, exhibited reduced body weight and plasma glucose concentrations were higher during the experimental period of 10 days (features insulinopenic state). However, vitamin D supplementation did not alter this condition. Diabetic mice, compared to controls, exhibited reduced body weight (p<0,05) and plasma glucose concentrations (p <0.001) higher during the trial period. Animals supplemented with vitamin D showed higher levels of 25 (OH) D than controls (CW vs CV, p <0,001; DW vs DV, p<0,001). Higher serum urea (CW vs. DW, p <0,05; CW vs DV, p <0,01; CV vs DA, p <0,05; CV vs DV, p <0,01) and creatinine (CW vs. DW, p <0,001; CW vs DV, p <0,001; CV vs DW, p <0,001; CV vs DW, p <0,001), thickening of Bowman\'s capsule, glomerular hypertrophy and destruction of hepatocytes were observed in diabetic mice compared to controls. However, vitamin D supplementation did not alter these conditions. The DW group showed lower serum albumin compared to CW (p<0,05) and CV (p<0,05) groups; lower hemoglobin (p<0,05) and hematocrit (p <0,05) compared to the DV group; and lower leukocyte counts compared to CW (p <0,05) and mononuclear blood (p <0,05) compared to the CW group. The results suggest that Vitamin D may influence the immune response in diabetic animals, modulating hematocrit, hemoglobin and serum albumin
Yousef, Fatimah Mohammadali. « Vitamin D Status and Breast Cancer in Saudi Arabian Women : Case Control Study ». Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202986.
Texte intégralAntonoglou, G. (Georgios). « Vitamin D and periodontal infection ». Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526209166.
Texte intégralTiivistelmä Tutkimuksen tarkoituksena oli selvittää seerumin 25-hydroksivitamiini D:n [25(OH)D, D-vitamiinin varastomuoto] ja 1,25-dihydroksivitamiini D:n [1,25(OH)2D, D-vitamiinin aktiivinen muoto] tasojen yhteyttä parodontiumin alueen infektiosairauksiin. Tulokset perustuvat kolmeen tutkimusasetelmaan: tapaus-verrokki-tutkimus (63 parodontiitti-potilasta, 30 verrokkia), interventio-tutkimus [80 tyypin 1 diabetes mellitus (T1DM) potilasta, joista 65 osallistui seurantaan parodontologisen hoidon jälkeen] ja poikittaistutkimus Terveys 2000 tutkimuksen osa-aineistossa (1262 30-49 vuotiasta tupakoimatonta ei-diabeetikkoa). Tapaus-verrokki- ja interventiotutkimuksissa tutkittiin myös seerumin parathormoonin (PTH) yhteyttä parodontaali-infektioon sekä PTH:n vaikutusta seerumin 1,25(OH)2D tasoon infektion hoidon jälkeen. D-vitamiinin ja PTH:n tasot määritettiin immunologisin menetelmin. Yhteyksiä tutkittiin käyttäen vakioituja monimuuttujamalleja. Tapaus-verrokki-tutkimuksessa yksilöt, joilla seerumin 1,25(OH)2D taso oli alhainen, kuuluivat todennäköisemmin parodontiitti- kuin verrokkiryhmään. Interventiotutkimuksen alkutilanteessa seerumin 1,25(OH)2D:n ja parodontaali-infektion vaikeusasteen välillä vallitsi tilastollisesti merkittävä käänteinen yhteys ja taso nousi merkittävästi infektion hoidon jälkeen. Myös seerumin PTH taso nousi parodontaali-infektion hoidon jälkeen; nousu oli tilastollisesti merkittävä (p = 0.016) pitkälle edennyttä parodontiittia sairastavilla. Interventiotutkimuksen tulokset viittaavat kausaaliseen yhteyteen 1,25(OH)2D:n ja parodontaali-infektion välillä. Alhainen seerumin 1,25(OH)2D pitoisuus infektion vallitessa voi selittyä sen suurella käytöllä immuunipuolustukseen infektion aikana tai lisääntyneellä hajoamisella. Tason nousu hoidon jälkeen tukee edellä mainittua. PTH on 25(OH)D:n hydroksylaation pääsäätelijä ja 1,25(OH)2D:n nousua hoidon jälkeen voi osittain selittää myös seerumin PTH tason kohoaminen. Seerumin 25(OH)D:n ja parodontaali-infektion välillä havaittu yhteys oli heikko, mutta ei täysin sulje pois 25(OH)D:n suojaavaa vaikutusta. Käänteinen yhteys löytyi vain interventiotutkimuksen alkutilanteessa T1DM potilailla. Infektion hoito ei vaikuttanut 25(OH)D tasoon. Terveys 2000 tutkimuksen osa-aineistossa havaittiin hyvän suuhygienian omaavilla jonkin verran alhaisempi määrä syventyneitä ientaskuja ylemmissä kuin alemmissa 25(OH)D kvintiileissä
Borradale, David. « Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland ». Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/26359/1/David_Borradale_Thesis.pdf.
Texte intégralBorradale, David. « Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland ». Queensland University of Technology, 2008. http://eprints.qut.edu.au/26359/.
Texte intégralProsser, David Eric. « Modeling and mechanistic studies of the mitochondrial vitamin D¦3, 25-hydroxylase ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0003/NQ38327.pdf.
Texte intégralDahl, Anna. « 25(OH)D-brist hos överviktiga barnoch ungdomar och desskorrelation till insulinresistens ». Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207668.
Texte intégralHill, Natasha Tremayne. « Vitamin D receptor and 1alpha, 25-dihydroxyvitamin D3 mediated regulation of DeltaNp63alpha ». Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1450456950.
Texte intégralPenlou, Sébastien. « Préparation d'haptènes de la vitamine D et obtention d'anticorps monoclonaux anti 25 hydroxyvitamine D pour la mise au point d'un immunodosage simultané des deux 25 hydroxyvitamines D2 et D3 ». Phd thesis, Université Claude Bernard - Lyon I, 2004. http://tel.archives-ouvertes.fr/tel-00952865.
Texte intégralFakler, Johannes, Antonia Grafe, Jamila Dinger, Christoph Josten et Gabriela Aust. « Perioperative risk factors in patients with a femoral neck fracture – influence of 25-hydroxyvitamin D and C-reactive protein on postoperative medical complications and 1-year mortality ». Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206107.
Texte intégralRockwell, Michelle S. « Vitamin D in Human Health and Performance : The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty ». Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/93168.
Texte intégralPh.D.
Vitamin D is known as the “sunshine vitamin” since it can be synthesized by the human body when exposed to specific wavelengths of ultraviolet-B (UVB) light. Some foods and dietary supplements also contain vitamin D. A relationship between vitamin D and bone health is well-established, but emerging research has also associated vitamin D status with a number of different diseases and health problems, including cancer, cardiovascular disease, autoimmune conditions, and depression. Unfortunately, this research is currently inconclusive, and healthcare providers’ professional guidelines related to vitamin D are highly variable. Thus, providing evidence-based care related to vitamin D is complicated. This dissertation consists of a series of three research studies that describe healthcare providers’ vitamin D-related care considering the uncertain landscape, and two research studies that explore the role of vitamin D in collegiate athletes. We chose athletes since a high proportion of them have deficient or insufficient vitamin D status, and because some research has shown that this low vitamin D status affects athletic performance. Results of these studies showed that vitamin D-related health services such as blood testing have increased dramatically over the past 15 years, as have costs associated with these services. Opportunities to improve consistency and quality of care were observed in multiple settings. In the athlete studies, a high rate of vitamin D deficiency and insufficiency was observed among basketball athletes, and we identified vitamin D supplement treatment protocol effective in improving vitamin D status. In addition, swimmers who took vitamin D supplements performed better on strength and conditioning tests than those who took placebo supplements. A favorable relationship between testosterone concentrations and vitamin D status was shown in both basketball athletes and swimmers. Continuing to conduct research focused on specific populations can help healthcare providers develop consistent, high quality, evidence-based care related to vitamin D.
Monticielo, Odirlei André. « Estudo dos polimorfismos BsmI e FokI do receptor da vitamina D e avaliação dos níveis séricos da 25-hidroxivitamina D em pacientes com lúpus eritematoso sistêmico ». reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/28358.
Texte intégralIntroduction: Vitamin D has pleiotropic actions on many chronic diseases. The expression of the VDR (vitamin D receptor) in various cells of the immune system strengthens the possible influence of vitamin D on autoimmune diseases. Genetic polymorphisms located in VDR gene may determine changes in the mechanisms of action of vitamin D, but with results still unknown. The BsmI VDR polymorphism was associated with systemic lupus erythematosus (SLE) in Asian patients. Studies with SLE patients in Brazil have not been conducted. Objectives: To investigate the possibility of BsmI and FokI polymorphisms of VDR gene causing increased risk for development of SLE and to evaluate the possible association of these polymorphisms with clinical and laboratory manifestations of the disease. To determine serum levels of 25-hydroxyvitamin D [25(OH)D)] in patients and to investigate the possible association of their concentrations with the studied polymorphisms and clinical and laboratory expressions of SLE. Materials and methods: Case-control study involving 195 SLE patients and 201 healthy controls from the same geographical area. The BsmI and FokI polymorphisms of VDR gene were studied. Serum 25(OH)D levels were measured in the cases. Genotyping was performed by Restriction Fragment Length Polymorphism-Polymerase Chain Reaction (RFLP-PCR), using primers and restriction enzymes specific for each polymorphism. The measurement of 25(OH)D was performed by chemiluminescence. The clinical and laboratory data were collected from medical records. Results: There was no statistically significant difference in genotypic and allelic frequencies of BsmI and FokI polymorphisms among European-derived cases and controls. There was no association between clinical and laboratory features in SLE patients and the studied polymorphisms. The mean serum levels of 25(OH)D were 25.51±11.43 ng/ml in SLE patients. When patients were classified according to vitamin D status, the following distribution was observed: 55 (30.4%) had normal (≥30 ng/ml), 63 (34.8%) insufficient (20-30 ng/ml), 52 (28.7%) deficient (<20 ng/ml) and 11 (6,1%) critically low serum levels (<10 ng/ml). Fifty six percent of patients with deficiency received at least 800 IU of vitamin D per day. Based on genotype distribution, 25(OH)D levels were significantly higher in patients carrying the f/f genotype, when compared to patients carrying the F/F genotype (31.614.1 ng/ml versus 23.09.2 ng/ml, p=0.004). Vitamin D levels were not associated with clinical and laboratory features of SLE. Conclusions: The BsmI and FokI polymorphisms did not present association with SLE in our European-derived studied patients. The FokI polymorphism showed significant influence on 25(OH)D levels, reinforcing its role in functional activity of VDR. This finding may be considered in future clinical and experimental studies involving vitamin D measurements. Serum concentrations of 25(OH)D required to maintain optimal musculoskeletal, cardiovascular and immune health should be individualized for each patient and new guidelines about vitamin D supplementation may have to take into consideration the individual genetic background. Genetic-specific definitions of ideal levels of vitamin D in SLE should therefore be established in future studies.
Rockell, Jennifer, et n/a. « Serum 25-hydroxyvitamin D concentrations and their determinants in the New Zealand population ». University of Otago. Department of Nutrition, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080929.142611.
Texte intégralByrd, Alyson. « Evidence for a receptor binding 24R,25-dihydroxyvitamin D¦3 in developing bone ». Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/MQ50730.pdf.
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