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1

Saleh Al-hisnawy, Zeena Fouad. « Effect of alcoholic extracts ( Cuminum cyminum,Thymus vulgaris and Menthe pulegium) and tri mixed and di mixed extracts on enterobactericea (E. coli , Brucella abortus, Salmonella entridius) growth in vitro ». Kufa Journal For Veterinary Medical Sciences 4, no 2 (31 décembre 2013) : 5–11. http://dx.doi.org/10.36326/kjvs/2013/v4i23971.

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The present study aimed to determine the effect of alcoholic extracts of ( Cuminum cyminum,Thymus vulgaris and Menthe pulegium) activity against some of enterobactericea of gram negative stain (E. coli , Brucella abortus Salmonella entridius) ,at a varying concentration of 10 mg/ml by using agar well diffusion methods. Different chemical detection methods indicate that Cuminum cyminum contained Flavonoids, Thumus vulgaris contained Reins and Saponins while Menthe pulegium contained Flavonoids. The result showed that Brucella abortus more sensitive for antimicrobial activity alcoholic extract of Menthe pulegium and equal to tri mixed alcoholic extracts and di mixed, one of( Cuminum cyminum and Menthe pulegium), Cuminum cyminum alcoholic extract and Thymus vulgaris alcoholic extract that showed zone inhibitions of (38.66, 26.66 , 24, 19.33, 8.66) mm respectively. E. coli was found to be sensitive for di mixed alcoholic extract of (Menthe pulegium and Thumus vulgaris) rcoreded zone inhibition 26.66mm although sensitive from di mixed of (Cuminum cyminum and Thumus vulgaris) alcoholic extract by zone inhibition 17.33mm while Cuminum cyminum alcoholic extract showed zone inhibition of 9.33mm. Bacteria Salmonella entritidis was found only sensitive for di mixed of (Cuminum cyminum and Thumus vulgaris) alcoholic extract recorded zone inhibition 16.66mm.
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Saleh Al-hisnawy, Zeena Fouad. « Effect of alcoholic extracts ( Cuminum cyminum,Thymus vulgaris and Menthe pulegium) and tri mixed and di mixed extracts on enterobactericea (E. coli , Brucella abortus, Salmonella entridius) growth in vitro ». Kufa Journal For Veterinary Medical Sciences 4, no 2 (31 décembre 2013) : 5–11. http://dx.doi.org/10.36326/kjvs/2013/v4i23971.

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The present study aimed to determine the effect of alcoholic extracts of ( Cuminum cyminum,Thymus vulgaris and Menthe pulegium) activity against some of enterobactericea of gram negative stain (E. coli , Brucella abortus Salmonella entridius) ,at a varying concentration of 10 mg/ml by using agar well diffusion methods. Different chemical detection methods indicate that Cuminum cyminum contained Flavonoids, Thumus vulgaris contained Reins and Saponins while Menthe pulegium contained Flavonoids. The result showed that Brucella abortus more sensitive for antimicrobial activity alcoholic extract of Menthe pulegium and equal to tri mixed alcoholic extracts and di mixed, one of( Cuminum cyminum and Menthe pulegium), Cuminum cyminum alcoholic extract and Thymus vulgaris alcoholic extract that showed zone inhibitions of (38.66, 26.66 , 24, 19.33, 8.66) mm respectively. E. coli was found to be sensitive for di mixed alcoholic extract of (Menthe pulegium and Thumus vulgaris) rcoreded zone inhibition 26.66mm although sensitive from di mixed of (Cuminum cyminum and Thumus vulgaris) alcoholic extract by zone inhibition 17.33mm while Cuminum cyminum alcoholic extract showed zone inhibition of 9.33mm. Bacteria Salmonella entritidis was found only sensitive for di mixed of (Cuminum cyminum and Thumus vulgaris) alcoholic extract recorded zone inhibition 16.66mm.
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V, Paheerathan. « In-vitro Evaluation of Anti-Urolithiatic Activity of Cuminum Cyminum Seed Extract on Calcium Oxalate Stone ». Journal of Natural & ; Ayurvedic Medicine 7, no 1 (4 janvier 2023) : 1–5. http://dx.doi.org/10.23880/jonam-16000370.

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The present study was undertaken to evaluate the Invitro Anti- urolithiatic activity of the selected plant Cuminum cyminum seed extract by using the titrimetry method. The work was performed by using invitro Anti- urolithiatic model for calculating percentage dissolution of Calcium oxalate stone. The standard drug was cystone. The seed extract of Cuminum cyminum showed the higher dissolution than the standard drug cystone. The 30mg/ml seed extract of Cuminum cyminum was highest among the test groups. This study has been primary evidence for Cuminum cyminum as the plant which possess Antiurolithiatic property.
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Tanapichatsakul, Chutima, Sarunpron Khruengsai et Patcharee Pripdeevech. « In vitro and in vivo antifungal activity of Cuminum cyminum essential oil against Aspergillus aculeatus causing bunch rot of postharvest grapes ». PLOS ONE 15, no 11 (24 novembre 2020) : e0242862. http://dx.doi.org/10.1371/journal.pone.0242862.

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Bunch rot in grapes is an aggressive disease and needs to be controlled during the postharvest period. We investigate the antifungal potential of Zanthoxylum bungeanum Maxim., Zanthoxylum rhetsa, Cuminum cyminum, Coriandrum sativum, and Zingiber montanum (J. Koenig) Link ex A. Dietr. essential oils against Aspergillus aculeatus that cause bunch rot disease on postharvest grapes. C. cyminum essential oil exhibited stronger significantly inhibition percentage of 95.08% than other treatments in in vitro assay. Cumin aldehyde (33.94%) and α-terpinen-7-al (32.20%) were identified as major volatile compounds in C. cyminum oil. Antifungal potential of C. cyminum oil was then tested in conidia germination and in vitro tests compared to cumin aldehyde and α-terpinen-7-al. Their EC50 values against the conidial germination were also estimated. Significant reduction of conidia germination was also detected in C. cyminum essential oil and cumin aldehyde at a concentration of 1,000 and 100 μg/mL, respectively. EC50 values of the C. cyminum essential oil, cumin aldehyde, and α-terpinen-7-al were 67.28 μg/mL, 9.31 μg/mL, and 13.23 μg/mL, respectively. In vivo assay, the decrease of the disease severity (0.69%) and incidence (1.48%) percentage of A. aculeatus on grape berries treated at 1,000 μg/mL of C. cyminum essential oil was significantly greater than that obtained from other treatments after 10 days incubation. In addition, grape berries treated with C. cyminum essential oil decreased weight loss and retained fruit firmness. The changing of total soluble solids, total phenolic content, and antioxidant activity are also delayed in treated fruits. Therefore, essential oil of C. cyminum may be applied as a biological antifungal agent to control A. aculeatus in postharvest grapes without any negative effects on its quality.
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Azimi, Solmaz, Shima Rahmani et Maghsoud Pazhouhandeh. « Effect of protein extracts of Amaranthus retroflexus (Amaranthaceae) and Cuminum cyminum (Apiaceae) on digestive proteinases and biological characters of Helicoverpa (Heliothis) armigera (Hübner) (Lepidoptera : Noctuidae) ». Canadian Entomologist 152, no 5 (5 juin 2020) : 646–62. http://dx.doi.org/10.4039/tce.2020.28.

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AbstractPlant proteinase inhibitors are among the promising biopesticides which are induced in plants tissues against the several Lepidoptera pests to inhibit digestive proteases. In this study, protein extracts of two nonhost plant seeds, Amaranthus retroflexus Linnaeus (Amaranthaceae) and Cuminum cyminum Linnaeus (Apiaceae), were examined on Helicoverpaarmigera (Hübner) (Lepidoptera: Noctuidae). The results obtained by using azocasein as a substrate showed that inhibitory activity of general proteases of the larvae fed on a diet incorporated with both inhibitors was dose dependent. Seed extracts of A. retroflexus and C. cyminum at the highest concentration showed that inhibition activities of chymotrypsin-like proteinase and trypsin-like proteinase were between 31–45% and 28–61%, respectively. Based on polyacrylamide gel electrophoresis, all of the proteinase isoforms, including those of A. retroflexus seed extracts, disappeared entirely, and only one band was detected in the seed extracts of C. cyminum. Larval mortality in the larvae fed on A. retroflexus and C. cyminum seed extracts was 56 ± 2.15 and 68 ± 2.23, respectively, but mortality in control (no seed protein extract) was 12 ± 2.34 individuals. Also, the life table parameters were affected significantly by A. retroflexus and C. cyminum protein seed extracts. Therefore, A. retroflexus and C. cyminum seed protein extracts showed inhibitory effect on H. armigera digestive proteinases and adverse effects on survival and fitness of the pest; hence, they could be introduced as a successful biopesticide in the near future.
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Raana Mahmood, Itrat Jawed, Nosheen, Raheela Najam, Nargis Anjum, Bushra Z Sayeed et Faiza Zafar. « Study of Analgesic Activity of Methanolic Extracts of Cuminum Cyminum (L.) and Centratherum Anthelminticum (L.) in Mice ». ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & ; DENTAL COLLEGE 24, no 2 (30 juin 2019) : 90–95. http://dx.doi.org/10.58397/ashkmdc.v24i2.36.

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Objective: This study was conducted to investigate and compare the analgesic activity of methanolic ex- tracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L)in mice. Methods: This study was conducted in the department of Pharmacology University of Karachi; 30 healthy mice were selected from animal house of Pharmacology department of University of Karachi for the study. All animals were divided into three groups, each group of 10 mice. Mice of Group 1 were given DMSO (Dimethyl sulphoxide) an organic solvent, mice of group 2 were given Methanolic extract of Cuminum Cyminum (L) and mice of group 3 were given Methanolic extract of Centratherum anthelminticum (L). The analgesic activity was investigated by tail flick test, heat is used to stimulate pain and observe analgesic activity, after a week of oral dosing of Methanolic extracts of seeds of Cuminum Cyminum (L) and Centratherum anthelminticum (L) in mice. Methanolic extracts of Cuminum Cyminum (L) and Centratherum anthelminticum (L) were insoluble in water so Dimethyl sulphoxide (DMSO) i.e. an organic solvent was used in this study (it is used for solutes that are insoluble in water). The methanolic extracts of Cuminum cyminum(L), Centratherum anthelminticum (L) and DMSO (dim- ethyl sulphoxide) were administered orally to three groups of mice for a week and on 7th day of dosing analgesic activity was tested through tail flick test, response is checked after 30, 60, 90, 120, 150, 180 and 240 minutes of 7th day of dosing. Results: The group of mice, which were given Methanolic extract of Cuminum cyminum(L)showed highly significant analgesic activity after 60, 90, 120, 150, 180 and 240 minutes of dosing. The group of mice which was given Methanolic extract of Centratherum anthelminticum (L) showed significant analgesic activ- ity after 60, 90, 120, 150, 180 andhighly significant analgesic activity after 240 min. of dosing on 7th day. Conclusion: The results indicate that both extracts of Cuminum Cyminum (L) and Centratherum anthelminticum (L)showed analgesic activity. On comparison Cuminum Cyminum (L) have more supe- rior analgesic potential than Centratherum anthelminticum (L).
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Alomar, Hatun A., Noha Fathallah, Marwa M. Abdel-Aziz, Taghreed A. Ibrahim et Wafaa M. Elkady. « GC-MS Profiling, Anti-Helicobacter pylori, and Anti-Inflammatory Activities of Three Apiaceous Fruits’ Essential Oils ». Plants 11, no 19 (5 octobre 2022) : 2617. http://dx.doi.org/10.3390/plants11192617.

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Eradication of Helicobacter pylori is a challenge due to rising antibiotic resistance and GIT-related disorders. Cuminum cyminum, Pimpinella anisum, and Carum carvi are fruits belonging to the Apiaceae family. Their essential oils were extracted, analyzed using GC-MS, tested for anti-H. pylori activity by a micro-well dilution technique, identified for potential anti-H. pylori inhibitors by an in-silico study, and investigated for anti-inflammatory activity using a COX-2 inhibition assay. Results showed that the main components of C. cyminum, P. anisum, and C. carvi were cumaldehyde (41.26%), anethole (92.41%), and carvone (51.38%), respectively. Essential oil of C. cyminum exhibited the greatest anti-H. pylori activity (3.9 µg/mL) followed by P. anisum (15.63 µg/mL), while C. carvi showed the lowest activity (62.5 µg/mL). The in-silico study showed that cumaldehyde in C. cyminum has the best fitting energy to inhibit H. pylori.C. cyminum essential oil showed the maximum ability to reduce the production of Cox-2 expression approaching celecoxib with IC50 = 1.8 ± 0.41 µg/mL, followed by the C. carvi oil IC50 = 7.3 ± 0.35 µg/mL and then oil of P. anisum IC50 = 10.7±0.63 µg/mL. The investigated phytochemicals in this study can be used as potential adjunct therapies with conventional antibiotics against H. pylori.
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Hasan S. AL-Dhaher, Areej. « Effect of Some Plants Extracts on the Mortality of the 4th Larval Instar Mosquitoes Culex quinquefasciatus ». Al-Qadisiyah Journal Of Pure Science 26, no 2 (24 février 2021) : 9–21. http://dx.doi.org/10.29350/qjps.2021.26.2.1291.

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In this study, the effect of water and alcoholic (ethanol) extracts of Caper Bush Capparis spinosa L., Cumine Cuminum cyminum L. , Black pepper Piper nigrum L., Sage Salvia sp. and Cat thyme Teucrium polium L. plants on the 4th instar larvae of Culex quinquefasciatus have been evaluated .The results showed that the water extract of P. nigrum had the highest effect on the larvae, with 48h LC50 155. 9 ppm followed by ethanol extracts of C. cyminum , C. spinosa and P. nigrum with 48h LC50 308.2 ,315.1and 791.4 ppm respectively. For all studied plants, the secondary compounds were identified. Alkaloids and phenol extracts from Capparis spinosa, Alkaloids, flavonoids and volatile oils from Cuminum cyminum and Alkaloids and volatile oils from Piper nigrum had been isolated. The volatile oils and alkaloids extracts of P. nigrum showed the highest effect with 48h LC50 values 6.3 and 10.2 ppm, respectively then the volatile oil extract and alkaloids extract of C. cyminum with 48h LC50 were 21.1 and 429.4 ppm respectively
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Ramya, S., T. Loganathan, M. Chandran, R. Priyanka, K. Kavipriya, G. Grace Lydial Pushpalatha, Devaraj Aruna, L. Ramanathan, R. Jayakumararaj et Vikrant Saluja. « Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil ». Journal of Drug Delivery and Therapeutics 12, no 2-S (15 avril 2022) : 110–18. http://dx.doi.org/10.22270/jddt.v12i2-s.5280.

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Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Pharmacological studies indicate that BASMs in seeds of C. cyminum exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. In the present study phytochemical screening, GCMS, FTIR profile of bioactive natural products from C. cyminum has been envisaged. Phytochemical screening revealed the presence of alkaloids, anthraquinones, carbohydrates, coumarins, flavonoids, glycosides, proteins, quinones, saponins, steroids, tannins and terpenoids. GC-MS analysis revealed the presence of 21 compounds, of which Cuminaldehyde was prominent. FTIR analysis showed the presence of a strong peak value for 15 compounds and medium peak value for 6 compounds. Many of the compounds in the list could be ADMET bioprospected for biomedical applications as natural drug leads. Keywords: Cuminum cyminum; Cuminaldehyde; Bioactive Natural Products; GCMS; FTIR
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Ramya, S., T. Loganathan, M. Chandran, R. Priyanka, K. Kavipriya, G. Grace Lydial Pushpalatha, Devaraj Aruna, L. Ramanathan, R. Jayakumararaj et Vikrant Saluja. « Phytochemical Screening, GCMS, FTIR profile of Bioactive Natural Products in the methanolic extracts of Cuminum cyminum seeds and oil ». Journal of Drug Delivery and Therapeutics 12, no 2-S (15 avril 2022) : 110–18. http://dx.doi.org/10.22270/jddt.v12i2-s.5280.

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Seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma. C. cyminum have been used in traditional medicine to treat a variety of diseases. Literature presents ample evidence for biomedical activities of cumin which is attributed to its bioactive secondary metabolites - terpenes, phenols, and flavonoids. Besides, health effects of cumin seeds have been experimentally validated through phytochemical analysis depicting the presence of a wide array of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinone, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Pharmacological studies indicate that BASMs in seeds of C. cyminum exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. In the present study phytochemical screening, GCMS, FTIR profile of bioactive natural products from C. cyminum has been envisaged. Phytochemical screening revealed the presence of alkaloids, anthraquinones, carbohydrates, coumarins, flavonoids, glycosides, proteins, quinones, saponins, steroids, tannins and terpenoids. GC-MS analysis revealed the presence of 21 compounds, of which Cuminaldehyde was prominent. FTIR analysis showed the presence of a strong peak value for 15 compounds and medium peak value for 6 compounds. Many of the compounds in the list could be ADMET bioprospected for biomedical applications as natural drug leads. Keywords: Cuminum cyminum; Cuminaldehyde; Bioactive Natural Products; GCMS; FTIR
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Taghizadeh, Mohsen, Mohammad Reza Memarzadeh, Zatollah Asemi et Ahmad Esmaillzadeh. « Effect of the cumin cyminum L. Intake on Weight Loss, Metabolic Profiles and Biomarkers of Oxidative Stress in Overweight Subjects : A Randomized Double-Blind Placebo-Controlled Clinical Trial ». Annals of Nutrition and Metabolism 66, no 2-3 (2015) : 117–24. http://dx.doi.org/10.1159/000373896.

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Background: The current study was performed to determine the effects of cumin cyminum L. intake on weight loss and metabolic profiles among overweight subjects. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 78 overweight subjects (male, n = 18; female, n = 60) aged 18-60 years old. Participants were randomly assigned into three groups to receive: (1) cumin cyminum L. capsule (n = 26); (2) orlistat120 capsule (n = 26) and (3) placebo (n = 26) three times a day for 8 weeks. Anthropometric measures and fasting blood samples were taken at baseline and after 8 weeks of intervention. Results: Consumption of the Cuminum cyminum L. and orlistat120 resulted in a similar significant decrease in weight (-1.1 ± 1.2 and -0.9 ± 1.5 vs. 0.2 ± 1.5 kg, respectively, p = 0.002) and BMI (-0.4 ± 0.5 and -0.4 ± 0.6 vs. 0.1 ± 0.6 kg/m2, respectively, p = 0.003) compared with placebo. In addition, taking Cuminum cyminum L., compared with orlistat and placebo, led to a significant reduction in serum insulin levels (-1.4 ± 4.5 vs. 1.3 ± 3.3 and 0.3 ± 2.2 µIU/ml, respectively, p = 0.02), HOMA-B (-5.4 ± 18.9 vs. 5.8 ± 13.3 and 1.0 ± 11.0, respectively, p = 0.02) and a significant rise in QUICKI (0.01 ± 0.01 vs. -0.005 ± 0.01 and -0.004 ± 0.01, respectively, p = 0.02). Conclusion: Taking cumin cyminum L. for eight weeks among overweight subjects had the same effects of orlistat120 on weight and BMI and beneficial effects on insulin metabolism compared with orlistat120 and placebo.
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Villarreal, José Pablo Villarreal, Pedro Rassier dos Santos, Maria Antonieta Machado Pereira da Silva, Rosaria Helena Machado Azambuja, Carolina Lambrecht Gonçalves, Jesus Jaime Hernández Escareño, Tânia Regina Bettin dos Santos, Claudio Martin Pereira de Pereira, Rogério Antonio Freitag et Patrícia da Silva Nascente. « Evaluation of phytotherapy alternatives for controlling Rhipicephalus (Boophilus) microplus in vitro ». Revista Brasileira de Parasitologia Veterinária 26, no 3 (septembre 2017) : 299–306. http://dx.doi.org/10.1590/s1984-29612017052.

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Abstract The objective of this study was to identify the main chemical components of the essential oil of Cuminum cyminum L. (cumin) and of the fixed oils of Bertholletia excelsa (Brazil nut) and of Helianthus annuus (sunflower seed). As well as testing the three oils and three different commercial synthetic acaricides against engorged females of Rhipicephalus (Boophilus) microplus in order to explore their acaricidal efficacy. Six different concentrations of the oils (200, 100, 50, 25, 12.5 and 6.25 mg/mL) and the active principles were evaluated with the Adult Immersion Test (AIT). The two main chemicals components of C. cyminum L. were the cuminaldehyde and the γ-terpinene. In both B. excelsa and H. annuus were the linoleic and oleic acid. C. cyminum L. showed high acaricidal activity (100%) over the engorged females and on their reproductive characteristat from the concentration of 100 mg/mL. B. excelsa and H. annuus had low acaricidal activity (39.39% and 58.75% in the concentration of 200 mg/mL respectively). The amidine and the pyrethroid (35.12% and 1.50% respectively). It can be concluded that the oil of C. cyminum L. may be a phytoterapic alternative for the cattle's tick control.
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Campana, Raffaella, Mattia Tiboni, Filippo Maggi, Loredana Cappellacci, Kevin Cianfaglione, Mohammad Reza Morshedloo, Emanuela Frangipani et Luca Casettari. « Comparative Analysis of the Antimicrobial Activity of Essential Oils and Their Formulated Microemulsions against Foodborne Pathogens and Spoilage Bacteria ». Antibiotics 11, no 4 (25 mars 2022) : 447. http://dx.doi.org/10.3390/antibiotics11040447.

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The antimicrobial activity of several essential oils (EOs) and their related microemulsions (MEs) was investigated. EOs were obtained from Cannabis sativa L. cv CS (C. sativa), Carum carvi L. (C. carvi), Crithmum maritimum L. (C. maritimum), Cuminum cyminum L. (C. cyminum), x Cupressocyparis leylandii A.B. Jacks & Dallim. (C. leylandii), Cupressus arizonica Greene (C. arizonica), Ferula assa-foetida L. (F. assa-foetida)., Ferula gummosa Boiss. (F. gummosa), Juniperus communis L. (J. communis), Juniperus x pfitzeriana (Spath) P.A. Schmidt (J. pfitzeriana), Pimpinella anisum L (P. anisum). Preliminary screening revealed that Cuminum cyminum, Crithmum maritimum, and Pimpinella anisum (10% v/v) were effective against all tested microorganisms (Escherichia coli ATCC 35218, Listeria monocytogenes ATCC 7644, Staphylococcus aureus ATCC 29213, Pseudomonas fluorescens DSM 4358, and Candida albicans ATCC 10231), with growth inhibition diameter from 10 to 25 mm. These EOs were used to formulate the MEs with an average size < 50 nm and a good stability over 30 days. EOs’ antimicrobial activity was further enhanced in the MEs, with a generalized lowering of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. C. cyminum-ME reached, in most cases, MIC two times lower (0.312%) than the corresponding EO (0.625%) and even eight times lower against S. aureus (0.156 vs. 1.25%). A more remarkable microbicide effect was noted for C. cyminum-ME, with MBC values eight times lower (from 0.312 to 0.625%) than the corresponding EO (from 2.5 to 5%). Overall, MEs resulted in an efficient system for EOs encapsulation, enhancing solubility and lowering concentration to exert antimicrobial efficacy.
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SOLTANBEIGI, Amir, Harun DIRAMAN et Mohammad Bagher HASSANPOURAGHDAM. « Chemical components of volatile oil and fatty acids of wild Bunium persicum (Boiss.) B. Fedtsch. and cultivated Cuminum cyminum L. populations ». Acta agriculturae Slovenica 117, no 2 (14 juillet 2021) : 1. http://dx.doi.org/10.14720/aas.2021.117.2.1335.

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<p>Volatile oil and fatty acids components of six various populations of wild Bunium persicum Boiss. (Bam and Zirkuh/Iran) and cultivated Cuminum cyminum L. (Rayen/Iran; Cukurcak, Taskopru and Asagialicomak/Turkey) species were investigated. The volatile oil content of Bam and Zirkuh populations were 3.9 and 4.7 %, respectively. The analysis of volatile oils by the GC/FID-MSD showed that γ-terpinene (33.62-39.62 %), cuminal (17.9-19.3 %), o-cymene (5.3-11.1 %), benzenemethanol, α-methyl- (7.4-9.5 %), 1-phenyl-1-butanol (6.4-8.4 %) and limonene (6.4-8.6 %) were the major components of B. persicum populations. Rayen, Cukurcak, Taskopru and Asagialicomak populations of C. cyminum had 2.6, 2.2, 2.0 and 2.5 % of volatile oil, respectively. Cuminal (22.8-37.6 %), benzenemethanol, α-methyl- (5.3-22.6 %), γ-terpinene (16.7-19.4 %), β-pinene (11.2-11.9 %) and 1-phenyl-1-butanol (5.4-12.5 %) were identified as the main components of C. cyminum. Fatty acids were detected by the GC/FID. In total, 15 fatty acids were characterised in B. persicum populations from Iran. Petroselinic acid (26.3-52.6 %), lauric acid (16.2-37.0 %) and linoleic acid (18.3-33.0 %) were the predominant fatty acids identified in Iranian populations. C. cyminum populations were rich in the same fatty acids but, the order was: petroselinic acid (47.5-55.5 %), linoleic acid (22.5-25.4 %) and lauric acid (13.4-24.2 %). Monounsaturated fatty acids (27.4-56.2 %) were the major subgroup. Overall, B. persicum populations from Iran and C. cyminum from Turkey were almost similar in fatty acids profile although they had wide diversity in the volatile oils compositional profile.</p>
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Raana Mahmood, Rahila Najam, Mohammad Irfan Khan et Talat Tariq. « Evaluation and Comparison of Anti-Epileptic Activity of Methanolic Extracts of Seeds of Cuminum Cyminum L. and Centratherum Anthelminticum L. in Seizure Model ». ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & ; DENTAL COLLEGE 23, no 1 (31 mars 2018) : 4–9. http://dx.doi.org/10.58397/ashkmdc.v23i1.44.

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Objective: Evaluation and comparison of anti-epileptic activity of methanolic extracts of seeds of Cuminum cyminum L. and Centratherum anthelminticum L. in strychnine-induced seizure model. Methods: The study was conducted in the Department of Pharmacology, University of Karachi. After 15 days of dosing, experiment was performed. A total of 40 healthy mice were selected from animal house of the Pharmacology department, University of Karachi, and were equally divided into four groups. Group 01 was on DMSO (dimethyl sulphoxide) organic solvent as control; Group 02 was on methanolic extract of Cuminum cyminum L. (500 mg/kg); Group 03 was on methanolic extract of Centratherum anthelminticum L. (200 mg/kg) and Group 04 was on reference drug diazepam (3 mg/kg). On the day of experiment, after giving doses of DMSO, methanolic extract of Cuminum cyminum L., methanolic extract of Centratherum anthelminticum L. and diazepam, respectively to all groups, strychnine was administered and animals were observed for latency period and duration of Mortality rate was also evaluated. Results: Group 02 and 03, receiving methanolic extracts of Cuminum cyminum L. and Centratherum anthelminticum L. showed significant seizure protection as observed by delayed seizure onset (p <0.001) and decreased total duration of convulsions in groups 02 and 03 (p£ 0.01, p£ 0.05) respectively. The mortality rate also decreased significantly (p £ 0.05) in comparison with group 01. Conclusion: Anticonvulsant activity of methanolic extracts of Cuminum cyminum L. and Centratherum anthelminticum L. could be due to their antioxidant activity and further enhanced by potentiation of GABAergic and glycinergic activity. Further studies are required to confirm exact mechanism of action.
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Kolait, Hiba, et Matthias Melzig. « Kreuzkümmel, Cuminum cyminum L. » Zeitschrift für Phytotherapie 36, no 05 (19 novembre 2015) : 229–35. http://dx.doi.org/10.1055/s-0041-105256.

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Patil, Swapnil B., Shreehari S. Takalikar, Madhav M. Joglekar, Vivek S. Haldavnekar et Akalpita U. Arvindekar. « Insulinotropic and β-cell protective action of cuminaldehyde, cuminol and an inhibitor isolated from Cuminum cyminum in streptozotocin-induced diabetic rats ». British Journal of Nutrition 110, no 8 (14 mars 2013) : 1434–43. http://dx.doi.org/10.1017/s0007114513000627.

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Cuminum cyminum, a commonly used spice, is known to have anti-diabetic action. The present study aims towards the isolation of bioactive components from C. cyminum and the evaluation of their insulin secretagogue potential with the probable mechanism and β-cell protective action. The anti-diabetic activity was detected in the petroleum ether (pet ether) fraction of the C. cyminum distillate and studied through in vivo and in vitro experiments. Bioactive components were identified through GC–MS, Fourier transform infrared spectroscopy and NMR analysis. The isolated components were evaluated for their insulin secretagogue action using rat pancreatic islets. Further, the probable mechanism of stimulation of islets was evaluated through in vitro studies using diazoxide, nifedipine and 3-isobutyl-1-methylxanthine. β-Cell protection was evaluated using the (1-(4,5-dimethylthiazol-2-yl)-3,5-diphenylformazan) (MTT) assay, the alkaline comet assay and nitrite production. The administration of the pet ether fraction for 45 d to streptozotocin-induced diabetic rats revealed an improved lipid profile. Cuminaldehyde and cuminol were identified as potent insulinotrophic components. Cuminaldehyde and cuminol (25 μg/ml) showed 3·34- and 3·85-fold increased insulin secretion, respectively, than the 11·8 mm-glucose control. The insulinotrophic action of both components was glucose-dependent and due to the closure of the ATP-sensitive K (K+-ATP) channel and the increase in intracellular Ca2+ concentration. An inhibitor of insulin secretion with potent β-cell protective action was also isolated from the same pet ether fraction. In conclusion, C. cyminum was able to lower blood glucose without causing hypoglycaemia or β-cell burn out. Hence, the commonly used spice, C. cyminum, has the potential to be used as a novel insulinotrophic therapy for prolonged treatment of diabetes.
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Коритнюк, Р. С., А. В. Кабачна, С. О. Соловйов, В. В. Трохимчук et М. І. Наумова. « Physical-chemical and biopharmaceutical research of ointments with cyminal ». Farmatsevtychnyi zhurnal, no 1 (27 février 2024) : 52–58. http://dx.doi.org/10.32352/0367-3057.1.24.06.

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Local wound treatment remains one of the most pressing problems of modern medicine. The effectiveness of local drug therapy with the use of various medications depends on the differentiated use of drugs depending on the phase of the wound process. Taking into account modern wound treatment technologies, it is important to develop the composition and technology of an application drug (cream, ointment, gel) taking into account not only the phase of the wound process, but also the Time-concept component, in particular the ability of the drug to create an optimal moist environment and have antimicrobial properties, since the absence of infection in the wound is the basis for successful healing. The aim of our study was to develop an optimal composition of ointment for wound treatment based on technological and physicochemical studies. The rheological properties of the samples were studied using a Reotest-2 rotational viscometer (USA) with a water circulating heater. The structural viscosity was determined at a temperature of 20 ± 0,2 °C. Thermostatization was performed in the ITZH-0-03 thermostat. The temperature was determined by a laboratory thermometer with a division price of 0,1 °C. The acid-base balance was determined potentiometrically according to the State Standard Form I. The pharmacokinetic parameters of the drug were determined by dialysis through a semipermeable membrane. The experimental ointment is a non-Newtonian fluid. Its fluidity begins after a certain mechanical stress is applied, i.e., after the kinetic energy of the particles of the structural frame increases, which leads to the breakdown of bonds between its elements. The maximum destruction of the system occurs at a temperature of 40 °С. The experimental data showed that the pH of the ciminal ointment is in the range from 5,5 to 7.5, which is optimal for the treatment of infected wounds. The pharmacokinetic parameters of the drug were determined: reaction rate of release of active substances; reaction rate constants, half-life. The kinetic processes of ciminals release from the drug are described by the first-order equation. The composition and technology of the ointment have been substantiated on the basis of experimental studies.
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Atrooz, Omar M. « Characterization and Effects of β–Galactosidase in the Crude Extracts of Cuminum cyminum and Curcuma longa in Preparation of Delactosed Milk and Whey ». Journal of Applied Biotechnology 5, no 1 (21 novembre 2016) : 1. http://dx.doi.org/10.5296/jab.v5i1.10212.

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<p>β-galactosidase (EC 3.2.1.23) was extracted from <em>Cuminum cyminum </em>and<em> Curcuma longa</em>. The crude extracts of these plants were then characterized in term of pH, temperature, and enzyme kinetic. The crude extracts were also used in hydrolysis of lactose in milk and whey. The enzyme activity was measured by its ability to hydrolyze the substrate o-nitrophenyl β -D-galactopyranoside (ONPG).</p><p>It was found that β-galactosidase in the crude extracts of <em>Cuminum cyminum </em>exhibited maximum activity at pH 8.0 and optimum temperature at 60 °C. While, β-galactosidase in the crude extracts of <em>Curcuma longa</em> have optimum pH at 5.0 and 7.0 and optimum temperature at 50 °C.The K<sub>m</sub> and V<sub>max</sub> values of the β-galactosidase in the crude extracts of <em>Cuminum cyminum</em> and <em>Curcuma longa </em>were 4.16 mM and 0.087 μmol/min, and 2.63 mM and 0.333μmol/min, respectively.</p><p>The results showed that 96.84-97.08% of lactose was hydrolyzed in cow’s milk and whey when treated with crude extracts of <em>Cuminum cyminum</em> and 90-98.6% when treated with crude extracts of <em>Curcuma longa</em>.</p>
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Shosha, Nehad Naem Hamed, Nouran Mohammed Fahmy, Abdel nasser B. Singab et Radwa Wahid Mohamed. « Anti-ulcer effects of cumin (Cuminum cyminum L.), thyme (Thymus vulgaris L.), and caraway (Carum carvi L.) essential oils on peptic ulcer and ulcerative colitis models in rats ». Journal of Herbmed Pharmacology 11, no 3 (25 juin 2022) : 389–400. http://dx.doi.org/10.34172/jhp.2022.45.

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Introduction: Essential oils are considered a potential alternative to synthetic drugs in the management of diseases such as peptic ulcer (PU) and ulcerative colitis (UC). This study is concerned with comparing the therapeutic effects of Cuminum cyminum L, Carum carvi L, and Thymus vulgaris L. essential oils on PU and UC models induced by ethanol. Methods: Rats were divided into 10 groups; control groups were treated with saline and experimental groups with 500 mg/kg body weight of C. cyminum, C. carvi, or T. vulgaris essential oil. Curative effects were determined by measuring tissue oxidative markers, such as reduced glutathione (GSH), malondialdehyde (MDA), and myeloperoxidase (MPO), as well as the inflammatory marker prostaglandin E2 (PGE2), stomach pepsin (PEP), and colon alkaline phosphatase (ALP). Biochemical and histological examinations were done on stomach and colon tissues. Results: The current study proved the anti-ulcer effects of C. cyminum, C. carvi, and T. vulgaris essential oils. They improved the oxidative and inflammatory markers in both stomach and colon tissues and modulated stomach PEP and colon ALP activities. T. vulgaris essential oil modulated GSH and MDA levels resulting in a significant elevation in GSH levels by 120.43% and 99.46% and a significant reduction in MDA levels by 20.05% and 24.1% in PU and UC models, respectively. C. carvi essential oil was the most effective in restoring PGE2 by 71.51% compared to UC group. Results were confirmed by the morphological and histopathological changes. Conclusion: C. cyminum, C. carvi, or T. vulgaris essential oils might be used in the management of acute PU and UC.
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Pakhira, Bhabani Prasad, Abhinandan Ghosh, Adrija Tripathy et Debidas Ghosh. « Antitesticular activities of different solvent fractions from hydro-methanol (2:3) extract of Cuminum cyminum in albino rat : A Comparative analysis ». International Journal of Phytomedicine 9, no 4 (28 décembre 2017) : 605. http://dx.doi.org/10.5138/09750185.2131.

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Currently available contraceptives are associated with adverse effects. So, search on safer agents in this purpose is one of the priority areas of WHO. Our previous study showed a significant antifertility effect of hydro-methanol extract of <em>Cuminum cyminum</em> Linn (Umbelliferae) in male albino rat. The main objective of this work isto search outthe potentfraction of hydro-methanol extract of seed of <em>Cuminum cyminum</em> in adult male albino rat for the development of herbal male contraceptive to reduce the bio-burden of phytomolecules. The n-hexane, chloroform, ethyl acetate, and n-butanol fractions of the hydro-methanol (2:3) extract of seed of <em>Cuminum cyminum</em> were administrated orally to male rat. Results showed the maximum antitesticular activity of chloroform fraction (CH-Fr) than other fractions included here. Treatment with CH-Fr fraction resulted a significant inhibition in spermiological parameters, activities of testicular androgenic key enzymes and antioxidative enzymes, levels of serum testosterone and seminal vesicular fructose, number of different generations of germ cells at stage VII of spermatogenic cell cycle and seminiferous tubular diameter (STD) along with significant increase in the level of testicular cholesterol in respect to the control. Significant upward and downward expression in Bax and Bcl-2 gene of male germ cells were indicated which focussed the sperm apoptotic enhancer activities of the fraction. The findings indicated that among the said four different fractions, the chloroform fraction of the hydro-methanol extract of the seed of <em>Cuminum cyminum</em> had most effective antitesticular activity.
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Dolatabadi, Samaneh, Zahra Salari et Mohaddese Mahboubi. « Antifungal effects of Ziziphora tenuior, Lavandula angustifolia, Cuminum cyminum essential oils against clinical isolates of Candida albicans from women suffering from vulvovaginal candidiasis ». Infectio 23, no 3 (19 mars 2019) : 222. http://dx.doi.org/10.22354/in.v23i3.784.

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Candida sp. especially C. albicans is the main cause of candidiasis in women in reproductive ages. The prevalence of drug resistant C. albicans along with adverse effects of current treatments have encouraged the scientists to research on medicinal plant’s essential oils. The aim of this study was to evaluate the potential effects of Ziziphora tenuior, Lavandula angustifolia, Cuminum cyminum essential oils against clinical isolates of C. albicans, which were isolated from women with vulvovaginal candidiasis. The anti-candidal effects of these commercial essential oils were screened against these clinical isolates (n=80) by disc diffusion and micro-broth dilution assays. The means of inhibition zone diameters, MIC and MFCs were reported for each essential oil. Also, the capability of fungal strain for biofilm formation in comparison with C. albicans ATCC 10231 were determined. The anti-biofilm effects of essential oils against 11 biofilm producing strains of C. albicans were determined. The results showed C. cyminum and Z. tenuior essential oils had the best anti-candidal effects, while the best biofilm killing effects was for L. angustifolia essential oil. C. cyminum and Z. tenuior essential oils can be formulated for more evaluations in preclinical and clinical studies.
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Zhang, Zhong, Qiang Qin, Ruojun Ding, Yibing Xia, Libo Xiong, Yang Bi et Dov Prusky. « Acidolysis-dominated pretreatment elevates distillation yield and impacts composition, antioxidant and antifungal activities of essential oil from Cuminum cyminum seeds ». RSC Advances 8, no 56 (2018) : 32283–95. http://dx.doi.org/10.1039/c8ra03575j.

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Jeliazkova, Ekaterina A., Valtcho D. Jeliazkov, Lyle E. Craker et Baoshan Xing. « Heavy Metals and Seed Germination in Medicinal and Aromatic Plants ». HortScience 33, no 2 (avril 1998) : 206d—206. http://dx.doi.org/10.21273/hortsci.33.2.206d.

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Phytoremediation has been suggested as a solution to heavy metal—polluted soils, but the choices of suitable plant species for phytoremediation have been limited. Medicinal and aromatic plants appear to be excellent selections for these plantings, since these plants are grown for economically valuable secondary products (essential oils), not for food or feed. Preliminary research indicates that heavy metals are not accumulated in essential oils, permitting the oil to be used commercially. Productivity of some, but not all aromatic plants was reduced, however, by the heavy metals. The objective of our experiment was to distinguish the mechanism of heavy metal tolerance of plants using germinating seeds of medicinal and aromatic plant species. Seeds from medicinal and aromatic plants were germinated in solutions with selected levels of heavy metals (cadmium at 6 and 10 (μg·L-1; copper at 60 and 150 μg·L-1; lead at 100 and 500 μg·L-1; zinc at 400 and 800 μg·L-1) and in distilled water. Tests on Anethum graveolens L., Carum carvi L., Cuminum cyminum L., Foeniculum vulgare Mill., Pimpinella anisum L., Ocimum basilicum L., and the hyperaccumulator species Brassica juncea L. and Alyssum bertolonii established that different plant species reacted in different ways to the heavy metals. For example, cadmium did not decrease seed germination of Alyssum, O. basilicum, and B. juncea compared with germination in water but did decrease germination of C. cyminum. Lead did not affect germination of A. bertolonii and B. juncea as compared with water but did negatively affect germination of P. anisum, F. vulgare, and C. cyminum. Except for B. juncea, F. vulgare, and C. cyminum, copper had a negative effect on germination. Zinc decreased germination in all tested species except B. juncea.
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Raana Mahmood, Rahela Najam, Mukesh Kumar et Sadia Saleem Rao. « Evaluation of Antihyperlipidaemic Activity of Methanolic Extract of Cuminum cyminum L. Seeds in Diet Induced Hyperlipidaemic Rabbits ». ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & ; DENTAL COLLEGE 22, no 1 (31 mars 2017) : 20–25. http://dx.doi.org/10.58397/ashkmdc.v22i1.92.

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Objective: To evaluate antihyperlipidaemic activity of methanolic extract of seeds of Cuminum cyminum L. in hyperlipidaemia in rabbits. Methods: This study was conducted in Pharmacology Department of University of Karachi; the duration of study was 30 days. Healthy rabbits were taken and hyperlipidaemia was induced by giving high cholesterol diet for four weeks. All animals were divided into three groups, with each group having ten rabbits (n=10).The methanolic extract of seeds of Cuminum cminum L. was dissolved in an organic solvent DMSO (Dimethyl-sulphoxide). One group was control-receiving DMSO, while second group received methanolic extract of Cuminum cyminum L. (MECC) 500mg/kg and third group re- ceived Atorvastatin 2mg/kg.Blood samples were taken at 0, 15th and 30th day of dosing and sent for the tests to Punjwani Centre for Molecular medicine & Drug research (PCMD) Diagnostic Laboratory. Results: The group that was given methanolic extract of Cuminum Cyminum L. showed decrease in High Density Lipoprotein (HDL) - cholesterol ratio (7.62 ± 4.01 to 4.45 ± 3.23) (p<0.05), cholesterol (208.54 ± 5.71 to 130.26 ± 5.72) (p<0.01), triglyceride (158.75 ± 5.23 to 136.14 ± 8.72) (p<0.001) and Low Density Lipoprotein (LDL) (168.17 ± 5.43 to 135.42±11.39) (p<0.001) and the group that was given Atorvastatin showed HDL-cholesterolratio(7.33 ± 3.27 to 3.12 ± 2.19) (p<0.01), cholesterol (208.11 ± 6.72 to 98.75 ± 3.77) (p<0.001), triglyceride (157.21 ± 6.72 to 141.25 ± 6.84) (p<0.01) and Low Density Lipoprotein (LDL) (167.25 ± 4.32 to 127.67 ± 10.96) (p<0.001) towards its normal levels from day 0 to 30th day of dosing on comparison to control, whereas triglycerides were significantly de- creased by extract than atorvastatin. Conclusion: The result of this study showed methanolic extract of Cuminum cyminum L. possesses antihyperlipidaemic activity.
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Freitas, Morgana A., Raynara I. A. Machado, Isabelle H. M. Rocha, Lorena S. Lima, Lucas P. Coutinho, Norberto K. V. Monteiro, Pedro L. Neto, Selma E. Mazzetto, Hugo A. O. Rocha et Richele J. A. Machado. « Determination of phenolic compounds and antioxidant potential of aqueous extracts of Curcuma longa L., Piper nigrum L. and Cuminum cyminum : an experimental and a quantum-mechanical study ». Journal of Health & ; Biological Sciences 10, no 1 (6 avril 2022) : 1. http://dx.doi.org/10.12662/2317-3076jhbs.v10i1.3859.p1-10.2022.

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Objectives: Evaluation of phenolic compounds and antioxidant activities of aqueous extracts of C. longa, P. nigrum and C. cyminum. In addition to proposing a quantum-mechanical model to evaluate the antioxidant activity. Methods: The aqueous extracts were prepared using roots of the Curcuma longa L., seeds of the Piper nigrum L. and seeds of Cuminum cyminum. The extracts were subjected to tests to detect and quantify phenolic compounds and to assess their antioxidant capacity by different methods. Furthermore, in order to investigate the electronic nature of the antioxidant activity of the main compounds present in these extracts, frontier molecular orbitals (FMOs) were obtained by DFT/B3LYP/6-31G(d,p) level of theory. Results: After statistical analysis of the results, a greater number of phenolic compounds and better antioxidant activity was identified in the aqueous extracts of cumin (C. cyminum) in all three assays performed, when compared to the other extracts tested. The theoretical model based on the Pietro method is in agreement with the experimental results. Conclusion: This study has an innovative proposal with the trivial antioxidant activity combined with theoretical quantum-mechanical calculations that can serve to reduce costs and time and to predict the antioxidant activity of subsequent studies.
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Karpagam K et Priya U. « Effectiveness of cumin cyminum plus lime administration on obesity among womens ». International Journal of Research in Pharmaceutical Sciences 10, no 4 (16 octobre 2019) : 2965–69. http://dx.doi.org/10.26452/ijrps.v10i4.1577.

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Obesity is a medical condition which occurs due to the accumulation of excess body fat to the extent that results in a negative effect in health. Obese are generally known when the body mass index (BMI) of a person is above 25. According to World health organization obesity and corpulent are defined as a risk of body health due to over or abnormal accumulation of fat in a human body. 50 (25 experimental groups and 25 control group) women's who met the inclusion criteria were selected by using non-probability convenience sampling technique. After selecting the sample, the investigator explained the purpose of the study and informed consent was obtained. Demographic variables were collected pre-test was done by using BMI for both experimental and control group. For the experimental group, cumin cyminum plus lime water is given for 3 weeks on an early morning in empty stomach. The data were tabulated and analyzed by descriptive and inferential statistics. The calculated ‘t’ value is significant at P< 0.005. The study indicates that administration of cumin cyminum plus lime water is effective in reducing overweight. The present study showed that cumin cyminum plus lime was not only beneficial but also safe and effective in the treatment of obesity.
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Reyes-Calderón, Almendra, Claudia Gutiérrez-García, Andrea G. Urióstegui-Pena, Aashish Srivastava, Liliana Aguilar-Marcelino, Hafiz M. N. Iqbal, Shiek S. S. J. Ahmed, Sujay Paul et Ashutosh Sharma. « Identification of Cumin (Cuminum cyminum) MicroRNAs through Deep Sequencing and Their Impact on Plant Secondary Metabolism ». Plants 12, no 9 (25 avril 2023) : 1756. http://dx.doi.org/10.3390/plants12091756.

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The pharmacological properties of plants lie in the content of secondary metabolites that are classified into different categories based on their biosynthesis, structures, and functions. MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial post-transcriptional regulatory roles in plants, including development and stress-response signaling; however, information about their involvement in secondary metabolism is still limited. Cumin is one of the most popular seeds from the plant Cuminum cyminum, with extensive applications in herbal medicine and cooking; nevertheless, no previous studies focus on the miRNA profile of cumin. In this study, the miRNA profile of C. cyminum and its association with the biosynthesis of secondary metabolites were determined using NGS technology. The sequencing data yielded 10,956,054 distinct reads with lengths ranging from 16 to 40 nt, of which 349 miRNAs were found to be conserved and 39 to be novel miRNAs. Moreover, this work identified 1959 potential target genes for C. cyminum miRNAs. It is interesting to note that several conserved and novel miRNAs have been found to specifically target important terpenoid backbone, flavonoid biosynthesis, and lipid/fatty acid pathways enzymes. We believe this investigation will aid in elucidating the implications of miRNAs in plant secondary metabolism.
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Mapari, Pankaj N., Faijuddin Ahammad, Rohit Kumar, Prafull Patil, Jagriti Thakur, Shivani Datre et Sobita Simon. « In vitro Assessment of Botanical Compatibility with Agaricus bisporus for Sustainable Disease Management ». Archives of Current Research International 24, no 5 (18 juin 2024) : 630–37. http://dx.doi.org/10.9734/acri/2024/v24i5736.

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Button mushroom (Agaricus bisporus) cultivation is a significant aspect of the global mushroom industry, the production of fruiting bodies is severely affected by fungal, bacterial and viral pathogens that can have an effect on yield and quality. Botanicals, such as plant extracts, have been reported to possess various bioactive compounds with potential benefits for mushroom growth and disease control. A lab experiment was carried out in the Department of Plant Pathology, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, to evaluate the compatibility of various botanicals viz., Allium sativum (garlic), Coriandrum sativum (coriander), Cuminum cyminum (jeera), Mentha spicata (pudina) with Agaricus bisporus in a Completely Randomised Design. In vitro evaluation was carried out using poison food technique at 10, 20 and 30% concentrations and 24, 48 & 72 hours of incubation. The maximum radial growth of Agaricus bisporus was observed in T0-Control (Agaricus bisporus) (17.86 mm), (16.82 mm) and (16.53 mm) and minimum in T3- Cuminum cyminum (jeera) (2.23 mm), (0.98 mm) and (0.39 mm) at 10, 20 and 30 percent concentration respectively. Maximum percentage of inhibition was observed in T3 - Cuminum cyminum (jeera) (87.51 %), (94.11 %) and (98.24 %) at 10, 20 and 30 percent concentration respectively.
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Ramya, S., T. Loganathan, M. Chandran, R. Priyanka, K. Kavipriya, G. Lydial Grace Lydial Pushpalatha, Devaraj Aruna, GC Abraham et R. Jayakumararaj. « ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications ». Journal of Drug Delivery and Therapeutics 12, no 2-S (15 avril 2022) : 127–41. http://dx.doi.org/10.22270/jddt.v12i2-s.5286.

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Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been experimentally validated through phytochemical screening deciphering the fact that it contains a large number of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinones, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Furthermore, pharmacological studies indicate that BASMs in CCS exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. Cuminaldehyde is one of the major bioactive compounds in CCS that holds significant pharmacological prominence. However, in-depth studies are lacking henceforth warranted to elucidate and fill the gaps, particularly on phytocompound isolation, pre-clinical, clinical characterization, and evaluation of structure–activity relationship. The present study prospects ADMETox perspectives of cuminaldehyde (4-Isopropylbenzaldehyde). Keywords: Cuminaldehyde; Isopropylbenzaldehyde; Cuminum cyminum; ADMETox; Natural Product (NP)
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Ramya, S., T. Loganathan, M. Chandran, R. Priyanka, K. Kavipriya, G. Lydial Grace Lydial Pushpalatha, Devaraj Aruna, GC Abraham et R. Jayakumararaj. « ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications ». Journal of Drug Delivery and Therapeutics 12, no 2-S (15 avril 2022) : 127–41. http://dx.doi.org/10.22270/jddt.v12i2-s.5286.

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Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been experimentally validated through phytochemical screening deciphering the fact that it contains a large number of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinones, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Furthermore, pharmacological studies indicate that BASMs in CCS exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. Cuminaldehyde is one of the major bioactive compounds in CCS that holds significant pharmacological prominence. However, in-depth studies are lacking henceforth warranted to elucidate and fill the gaps, particularly on phytocompound isolation, pre-clinical, clinical characterization, and evaluation of structure–activity relationship. The present study prospects ADMETox perspectives of cuminaldehyde (4-Isopropylbenzaldehyde). Keywords: Cuminaldehyde; Isopropylbenzaldehyde; Cuminum cyminum; ADMETox; Natural Product (NP)
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Ramya, S., T. Loganathan, M. Chandran, R. Priyanka, K. Kavipriya, G. Lydial Grace Lydial Pushpalatha, Devaraj Aruna, GC Abraham et R. Jayakumararaj. « ADME-Tox profile of Cuminaldehyde (4-Isopropylbenzaldehyde) from Cuminum cyminum seeds for potential biomedical applications ». Journal of Drug Delivery and Therapeutics 12, no 2-S (15 avril 2022) : 127–41. http://dx.doi.org/10.22270/jddt.v12i2-s.5286.

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Cuminum cyminum L (Family: Apiaceae) is a small multipurpose herb. Seeds of cumin are widely used as a spice for its distinctive aroma, and more commonly in various indigenous traditional systems of medicine. Access through web literature provides ample evidence for biomedical activities of Cuminum cyminum seeds (CCS). CCS has been used in traditional medicine to treat variety of diseases, including hypolipidemia, cancer, and diabetes. Biomedical properties of CCS is attributed to its phytochemical class of compounds viz., terpenes, phenols and flavonoids. Health effects of CCS have been experimentally validated through phytochemical screening deciphering the fact that it contains a large number of bioactive secondary metabolites (BASMs) viz., alkaloid, coumarin, anthraquinones, flavonoid, glycoside, protein, resin, saponin, tannin and steroid. Furthermore, pharmacological studies indicate that BASMs in CCS exert antimicrobial, insecticidal, anti-inflammatory, analgesic, antioxidant, anticancer, antidiabetic, anti-platelet-aggregation, hypotensive, bronchodilatory, immunological, contraceptive, anti-amyloidogenic, anti-osteoporotic, aldose reductase, α-glucosidase and tyrosinase inhibitory effects. Cuminaldehyde is one of the major bioactive compounds in CCS that holds significant pharmacological prominence. However, in-depth studies are lacking henceforth warranted to elucidate and fill the gaps, particularly on phytocompound isolation, pre-clinical, clinical characterization, and evaluation of structure–activity relationship. The present study prospects ADMETox perspectives of cuminaldehyde (4-Isopropylbenzaldehyde). Keywords: Cuminaldehyde; Isopropylbenzaldehyde; Cuminum cyminum; ADMETox; Natural Product (NP)
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Esmaeili, Farshid. « Composition of Essential Oil ofCuminum cyminum ». Journal of Essential Oil Bearing Plants 18, no 2 (4 mars 2015) : 507–9. http://dx.doi.org/10.1080/0972060x.2014.989186.

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Özer, G., et H. Bayraktar. « Determination of fungal pathogens associated with Cuminum cyminum in Turkey ». Plant Protection Science 51, No. 2 (2 juin 2016) : 74–79. http://dx.doi.org/10.17221/51/2014-pps.

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Lal, Uma Ranjan, Shailendra Mani Tripathi, Sanjay M. Jachak, Kamlesh Kumar Bhutani et Inder Pal Singh. « RP-HPLC Analysis of Jirakadyarishta and Chemical Changes during Fermentation ». Natural Product Communications 5, no 11 (novembre 2010) : 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501113.

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Jirakadyarishta, an Ayurvedic formulation prepared by the fermentation of a decoction of Cuminum cyminum (seeds) is traditionally used for intestinal disorders. RP-HPLC analysis of the decoction and the final processed formulation revealed that apigenin-7- O-[galacturonide (1→4)- O-glucoside] and luteolin-4′- O-glucoside-7- O-galacturonide) were the two major constituents of the decoction of C. cyminum. Selective hydrolysis of 7 -O-glucosides of luteolin and apigenin during fermentation resulted in an increase in the amount of luteolin and apigenin. The 4′- O-glucoside-7- O-galacturonide of luteolin and galacturonide derivative of apigenin were not hydrolyzed during fermentation. Monomeric phenolics, together with 5-hydroxymethyl furfural (5-HMF), were also introduced into the formulation through the jaggery and other plant materials during fermentation. This communication highlights the importance of the ancient processing methods used in Ayurveda.
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Majid Khan, Hina, Bushra Bibi, Erum Dilshad et Rehana Rani. « Identification of Anticancer Potential of Phytoconstituents of Cuminum cyminum Effective against Hepatocellular Carcinoma Using Computational Approaches ». Life and Science 4, no 3 (4 juillet 2023) : 14. http://dx.doi.org/10.37185/lns.1.1.302.

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Objective: To explore anticancer agents from Cuminum cyminum against hepatocellular carcinoma.Study Design: In-silico approaches using computational tools to determine the anticancer potential of phytoconstituents of cumin against hepatocellular carcinoma.Place and Duration of Study: This study was conducted from May 2021 to January 2022 at the Department of Bioinformatics and Biosciences of Capital University of Science and Technology, Islamabad, Pakistan.Materials and Methods: In this study, bioactive compounds of Cuminum cyminum representatives of Flavonoids, Phenolic acids, Terpenes, and Glycosides were selected to determine the anticancer potential of these ligands using an in-silico approach. Virtual screening of these ligands was carried out against the drug target, which was Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2). To identify novel anticancer bioactive compounds of Cuminum cyminum as potential inhibitors of VEGFR-2, Lipinski rule of five, Pharmacokinetic properties, and molecular docking were performed. Lipinski's rule of five and the Pharmacokinetic properties of ligands were studied through the pkCSM tool. Auto-dock performed molecular docking.Results: From these selected compounds, four ligands showed themselves as hit compounds. Among them, Quercetin was selected as the lead compound in this research against VEGFR-2 because it showed a -10.14 kcal/mol binding score and showed more active results with less toxic effects than the standard drug, which was Lenvatinib. All ligands-protein interaction visualization analyses were performed by PyMol molecular visualization tool and Discovery tool.Conclusion: Quercetin was identified as a lead compound that should be explored as a drug candidate in wet lab analysis to validate its efficacy for the treatment of HCC.
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Omar, A. F., M. E. El-Ebiary, G. M. Nasr et H. M. Hassan. « Toxicity and Biochemical Effects of Cumin and Basil Essential Oils on Tribolium Castaneum ». Scientia Agriculturae Bohemica 52, no 3 (1 septembre 2021) : 39–48. http://dx.doi.org/10.2478/sab-2021-0005.

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Abstract The essential oils (EOs) of cumin (Cuminum cyminum L.) seeds and basil (Ocimum basilicum L.) herb were extracted by hydrodistillation and tested against the red flour beetle, Tribolium castaneum (Herbst) for insecticidal and biochemical effects on certain enzymes of this insect. Major components of C. cyminum EO determined by gass chromatography-mass spectrometry (GC/MS) analysis were γ-terpinene (15.78 %) and benzenemethanol (11.32 %), while those of O. basilicum EO were linalool (56.7 %) and epi-α-cadinol (11.4 %). The lethal concentration values for 50% mortality after three days of T. castaneum whole body exposure were 678 mg kg–1 for cumin oil and 755 mg kg–1 for basil oil. The enzymatic activity of treated insects showed a reduction in total protein, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase compared to untreated ones. However, α-amylase activity increased with both tested EOs. Hence, for T. castaneum control, these EOs may represent alternatives to conventional insecticides.
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Kumar, Suresh, et Suman Chowdhury. « Kinetics of acetylcholinesterase inhibition by an aqueous extract of Cuminum cyminum seeds. » International Journal of Applied Sciences and Biotechnology 2, no 1 (25 mars 2014) : 64–68. http://dx.doi.org/10.3126/ijasbt.v2i1.9348.

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The cholinergic hypothesis of Alzheimer’s disease (AD) has provided the rationale for the current pharmacotherapy of this disease. Acetylcholinesterase (AChE) inhibitors are currently the only approved therapy for the symptomatic treatment of AD. The current drugs available in the market has shown various side effect which prompted scientist to search for new and potent AChE inhibitors which exerts minimal side effect in AD patient. In present study, an aqueous extract of Cumin cyminum was tested for in vitro acetylcholinesterase inhibitory activity based on Ellman’s method. C. cyminum showed maximum inhibition of 76.90±0.003% in an aqueous extract at 50μg/ml final concentration. Further studies were conducted to elucidate the mode of AChE inhibition by kinetic studies. Competitive inhibition was observed at lower concentrations (12.5μg/ml & 25μg/ml) and mixed inhibition was observed at higher concentrations (50μg/ml & 100μg/ml). DOI: http://dx.doi.org/10.3126/ijasbt.v2i1.9348 Int J Appl Sci Biotechnol, Vol 2(1): 64-68
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Jafar Teaimah, Sadeq, Kadhim Saleh Al-Hadlag et Nasir Abd Ali Hlif. « Evaluation of the Activity of some Plant Extracts and Malathion on the Control of Callosobruchus maculatus ». Sumer 1 8, CSS 1 (15 août 2023) : 1–8. http://dx.doi.org/10.21931/rb/css/2023.08.01.66.

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This study aimed to evaluate the efficacy of some plant extracts on the control of callosobruchus maculatus.The plant extracts were Cuminum cyminum seeds, Nerium oleander leaves, and Conocarpus erotica leaves at three concentrations: 0.5, 1, and 2% compared to the pesticide malathion 1.25ml. l-1 against the southern bean insect Callosobruchus maculatus. Results showed that the ethanolic Conocarpus erotica leaves extract 2% achieved the highest mortality percentages to eggs, larvae and pupae by the values 12.86, 77.14, and 17.12 %, compared to malathion, 77.7, 95.3, 70.36 % respectively, followed by ethanolic Nerium oleander leaves extract 2%. In contrast, the aqueous and ethanolic extracts of Cuminum cyminum seeds performed the lowest effects. Repellent activities of Conocarpus erotica leaves and Nerium oleander leaves extracts gave a good and higher effect, especially with the highest concentration, 2%, and when extracted by ethanol. These extracts could be recommended in integrated pest management programs to protect cowpea seeds against Callosobruchus maculatus. Keywords:- Plant extracts, Mortality, Repellency effect, Callosobruchus maculatus.
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Satria, Satria, Marhayani Marhayani et Rizky Rinaldi. « Pengaruh Penambahan Tepung Jintan Putih (Cuminum cyminum) Dalam Pakan Terhadap Konsumsi Dan Efisiensi Pakan Pada Ayam Ras Petelur ». JAGO TOLIS : Jurnal Agrokompleks Tolis 4, no 1 (1 décembre 2023) : 71. http://dx.doi.org/10.56630/jago.v4i1.533.

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Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pemberian tepung jintan putih (Cuminum cyminum) ke dalam pakan ternak, mempengaruhi konsumsi dan efisiensi pakan ayam ras petelur afkir. Studi ini dilakukan dari Januari hingga Februari 2022 di Laboratorium STIP Mujahidin Tolitoli dan di Kandang milik SMK Negeri 1 Galang Kabupaten Tolitoli. Studi ini menggunakan Rancangan Acak Lengkap (RAL), yang terdiri dari empat perlakuan, empat ulangan, dan dua ekor ayam untuk setiap ulangan. Konsumsi pakan, konsumsi air minum, dan efisiensi pakan adalah variabel yang diamati dalam penelitian ini Perlakuan tepung jintan putih (TJP) meliputi: P0 (pakan + TJP 0%); P1 (pakan + TJP 1%); P2 (pakan + TJP 2%) dan P3 (pakan + TJP 3%). Hasil penelitian menunjukkan bahwa ayam petelur afkir tidak mengalami pengaruh yang signifikan (P>0,05) terhadap konsumsi pakan, konsumsi air minum, dan efisiensi pakan ketika tepung jintan putih ditambahkan pada tiga perlakuan.Kata Kunci : Tepung jintan putih, Cuminum cyminum, konsumsi pakan, konsumsi air minum, efisiensi pakan, ayam ras petelur
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Bose, Debajyoti. « POTENTIALS OF CUMINUM CYMINUM IN MICROBIAL CONTROL ». International Journal of Advancement in Life Sciences Research 1, no 2 (15 avril 2018) : 8–12. http://dx.doi.org/10.31632/ijalsr.2018v01i02.002.

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Johri, RK. « Cuminum cyminum and Carum carvi : An update ». Pharmacognosy Reviews 5, no 9 (2011) : 63. http://dx.doi.org/10.4103/0973-7847.79101.

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Gupta, Dipali, et Shekhar Bhargava. « Thidiazuron Induced Regeneration in Cuminum cyminum L ». Journal of Plant Biochemistry and Biotechnology 10, no 1 (janvier 2001) : 61–62. http://dx.doi.org/10.1007/bf03263109.

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Kolokolova, A. P., et M. A. Subotyalov. « Therapeutic potential of the plant Cuminum cyminum ». Традиционная медицина, no 4 (2022) : 27–34. http://dx.doi.org/10.54296/18186173_2022_4_27.

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Rosa, J. S., L. Oliveira, R. M. O. F. Sousa, C. B. Escobar et M. Fernandes-Ferreira. « Bioactivity of some Apiaceae essential oils and their constituents against Sitophilus zeamais (Coleoptera : Curculionidae) ». Bulletin of Entomological Research 110, no 3 (9 décembre 2019) : 406–16. http://dx.doi.org/10.1017/s0007485319000774.

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AbstractSitophilus zeamais is a key pest of stored grains. Its control is made, usually, using synthetic insecticides, despite their negative impacts. Botanical insecticides with fumigant/repellent properties may offer an alternative solution. This work describes the effects of Anethum graveolens, Petroselinum crispum, Foeniculum vulgare and Cuminum cyminum essential oils (EOs) and (S)-carvone, cuminaldehyde, estragole and (+)-fenchone towards adults of S. zeamais. Acute toxicity was assessed by fumigation and topical application. Repellence was evaluated by an area preference bioassay and two-choice test, using maize grains. LC50 determined by fumigation ranged from 51.8 to 535.8 mg L−1 air, with (S)-carvone being the most active. LD50 values for topical applications varied from 23 to 128 µg per adult for (S)-carvone > cuminaldehyde > A. graveolens > C. cyminum > P. crispum. All EOs/standard compounds reduced significantly the percentage of insects attracted to maize grains (65–80%) in the two-choice repellence test, whereas in the area preference bioassay RD50 varied from 1.4 to 45.2 µg cm−2, with cuminaldehyde, (S)-carvone and estragole being strongly repellents. Petroselinum crispum EO and cuminaldehyde affected the nutritional parameters relative growth rate, efficiency conversion index of ingested food and antifeeding effect, displaying antinutritional effects toward S. zeamais. In addition, P. crispum and C. cyminum EOs, as well as cuminaldehyde, showed the highest acetylcholinesterase inhibitory activity in vitro (IC50 = 185, 235 and 214.5 µg mL−1, respectively). EOs/standard compounds exhibited acute toxicity, and some treatments showed antinutritional effects towards S. zeamais. Therefore, the tested plant products might be good candidates to be considered to prevent damages caused by this pest.
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Mahdi, Osama S. « Evaluation of inhibitory activity of extracts of Apium gravelens, Coriandrum sativum and Cuminum cyminum against number of pathogenic bacteria ». Kufa Journal For Veterinary Medical Sciences 2, no 2 (30 décembre 2011) : 37–50. http://dx.doi.org/10.36326/kjvs/2011/v2i23912.

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Natural resources especially plants are useful bactericides for the control of bacterial infection .To evaluate the antibacterial potential of three types of plants, essential oils were extracted from the seeds of Apium gravelens, Coriandrum sativum and Cuminum cyminum and assayed in vitro for antibacterial activity aganist most prevalent pathogens Staphylococcus aureus, Salmonella spp.,Escherishia coli and Pseudomonas aeruginosa at 37 º C and 25 ºC.The antimicrobial effect was assessed using agar diffusion method by applying ethanolic solutions of extracts using it in two different temperatures 37 ºC and 25 ºC. The result shows that the extract of Apium gravelens, Coriandrum sativum and Cuminum cyminum alcoholic extract at 25 ºC exhibited an inhibition zone on S. aureus in the concentration 200 mg/ml and had a exhibited significantly (p < 0.05) greater than that produced by gentamicine,also the extract of Apium gravelens at 25 ºC in the concentration 100 mg/ml had a significant antibacterial activity on S. aureus, and the extract of Apium gravelens alcoholic extract at 25 ºC and 37 ºC pronounced antibacterial activity against Pseudomonas aeruginosa in the concentration 100 and 200 mg/ml respectively moreover the inhibition produced by gentamicine. While the antibacterial effect Apium gravelens and Coriandrum sativum at 37 ºC on S. aureus in the concentration 200 mg/ml show very similar effect with gentamicine. The antibacterial activity against Salmonella spp.and E. coli were moderate in action It was found that the investigated extracts of Apium gravelens , Coriandrum sativum and Cuminum cyminum were exhibited a considerable inhibitory effect against S. aureus and extracts of Apium gravelens and Coriandrum sativum against P. aerogene. The significant antibacterial activity appears promising.
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Chandran, M., R. Priyanka, D. Kavipriya, S. Ramya, R. Jayakumararaj, T. Loganathan, G. Pandiarajan et al. « Reformulation and Scientific Evaluation of CUSOCO : A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis ». Journal of Drug Delivery and Therapeutics 12, no 5 (15 septembre 2022) : 127–31. http://dx.doi.org/10.22270/jddt.v12i5.5604.

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In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic. Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care
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Pajohi Alamoti, Mohammadreza, Behnaz Bazargani-Gilani, Razzagh Mahmoudi, Anna Reale, Babak Pakbin, Tiziana Di Renzo et Ata Kaboudari. « Essential Oils from Indigenous Iranian Plants : A Natural Weapon vs. Multidrug-Resistant Escherichia coli ». Microorganisms 10, no 1 (5 janvier 2022) : 109. http://dx.doi.org/10.3390/microorganisms10010109.

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Aim of this study was to investigate the antimicrobial properties of herbal plant essential oils (EOs) from selected Iranian plant species such as Ferulago angulata, Zataria multiflora, Cuminum cyminum, and Mentha longifolia against antibiotic-resistant Escherichia coli (E. coli) strains. For this purpose, the Escherichia coli strains, isolated from raw cow’s milk and local dairy products (yogurt, cream, whey, cheese, and confectionery products) collected from different areas of Hamedan province, Iran, were investigated for their resistance to antibiotics (i.e., streptomycin, tetracycline, gentamicin, chloramphenicol, ciprofloxacin, and cefixime). Thus, the E. coli strains were tested for their susceptibility to the above-mentioned essential oils. Regarding antibiotics, the E. coli strains were highly sensitive to ciprofloxacin. In relation to essential oils, the most effective antibacterial activity was observed with Zataria multiflora; also, the bacteria were semi-sensitive to Cuminum cyminum and Mentha longifolia essential oils. All strains were resistant to Ferulago angulata essential oil. According to the results, the essential oil of Zataria multiflora can be considered as a practical and alternative antibacterial strategy to inhibit the growth of multidrug-resistant E. coli of dairy origin.
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Suzan Adil Rashid Al-Naqeeb. « The effect of some plant extracts on the resistance Staphylococcus spp ». Tikrit Journal of Pure Science 26, no 3 (4 décembre 2022) : 12–17. http://dx.doi.org/10.25130/tjps.v26i3.135.

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Staphylococci spp ubiquitous, including a different species as normal flora. The most virulent and resistant to antibiotic are Staphylococcus aureus and mutans, species which colonizes epithelial surfaces and causes dangerous humans infections. The objectives of this study is studying and Using the agar agar weal diffusion process, researchers tested the The degree of susceptibility of bacteria from one type of plant extract to another varies for six different concentrations using several methods (50, 100, 200, 300, 400, 500 mg/ml) of each Aqueous and alcoholic plant extracted were used then evaluated. The alcoholic Ziziphus In this study, we see that the strongest activity of the extract against the tested bacterium Ziziphus. this analysis. Turmeric, alcoholic, and aqueous extracts, on the other hand, had comparable antimicrobial activity but at higher concentrations. However, against S. aureus and S. mutans, the aqueous extract of cuminum cyminum had no inhibitory action. The S. aureus isolates seemed to be resistant to the extracts of Ziziphus and Tumeric. The S. mutans isolate, on the other hand, was more susceptible to cuminum cyminum, but only at low concentrations
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Rescia, Laura. « Guillaume Colletet, Cyminde ou les deux victimes (1642) ». Studi Francesi, no 197 (LXVI | II) (1 août 2022) : 414. http://dx.doi.org/10.4000/studifrancesi.49894.

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