Littérature scientifique sur le sujet « Cstnud »
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Articles de revues sur le sujet "Cstnud"
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Cruz-Flores, Gerardo, Eloisa A. Guerra-Hernández, Juan M. Valderrábano-Gómez et Julio Campo-Alvés. « Indicadores de calidad de suelos en bosques templados de la Reserva de la Biosfera los Volcanes, México ». REVISTA TERRA LATINOAMERICANA 38, no 4 (11 octobre 2020) : 781–93. http://dx.doi.org/10.28940/terra.v38i4.421.
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La degradación y erosión edáfica por cambios de uso suelo, disminuyen los contenidos de carbono y su calidad. Con el objetivo de identificar y reconocer los mejores indicadores de calidad edáfica y de relacionarla con sus contenidos de carbono orgánico, se realizó esta investigación en bosques de la Reserva de la Biósfera los Volcanes. Se seleccionaron 26 sitios distribuidos entre 2600 y 3800 m de altitud colectando muestras de suelo de 0 a -0.2 m para análisis físicos y químicos y entre 0 a -0.1 m para bioquímicos y biológicos. Los resultados mostraron como excelentes indicadores parciales para evaluar calidad del suelo (IpCS) al pH, porcentaje de arena; contenido gravimétrico de agua, carbono orgánico, Ca+2 y K+ intercambiables; carbono de biomasa microbiana y actividad fosfatasa ácida y presencia/abundancia de bacterias y algas. Con estos IpCS, se determinó aditiva y conmutativamente, calidad total del suelo (CSTsum y CSTmul) cuyas tendencias fueron similares, aunque el modelo aditivo, muestra mejor que bosques afectados y vegetación secundaria (2600 y 2700 m) tienen menor calidad edáfica, mientras que en la franja media (3000-3300 m) con bosques de Abies y mixto Abies-Pino, los suelos tuvieron mayores contenidos de carbono orgánico y altas CSTsum y CSTmul.
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Fu, Ning, Xue-chang Ren et Jian-xin Wan. « The Effect of Molar Ratios of Ti/Si on Core-Shell SiO2@TiO2 Nanoparticles for Photocatalytic Applications ». Journal of Nanomaterials 2020 (27 avril 2020) : 1–11. http://dx.doi.org/10.1155/2020/5312376.
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After the core-shell SiO2@TiO2 nanoparticles (CSTNs) were synthesized by hydrothermal method, we investigated the influence of different molar ratios of Ti/Si on morphology, structure, and photocatalytic activity of the CSTNs. It was found that the CSTNs showed different size and surface morphology as the Ti/Si molar ratio changed. Besides, the TiO2 and the CSTN had the anatase phase after hydrothermal process and calcination at 450°C for 2 h. The N2 adsorption-desorption isotherms demonstrated the CSTNs with the molar ratio of Ti/Si increased from 1 : 1 to 8 : 1 can be categorized as type IV with hysteresis loop of type H2 and showed to be mesoporous materials. In addition, the CSTNs with the Ti/Si molar ratio of 5 : 1 had the highest surface area of 176.79 m2/g. Surface charges showed the isoelectric point (IEP) of the CSTNs ranged between silica (IEP at pH 3.10) and titania (IEP at pH 5.29). Since the molar ratio of Ti/Si increased from 1 : 1 to 8 : 1 by degradating both colorless organic pollutant of phenol and colored substances of methylene blue (MB) under UV irradiation, the photocatalytic activity of CSTNs exhibited higher photodegradation efficiency compared with TiO2. What is more, the experimental results also showed the CSTNs with Ti/Si molar ratio of 5 : 1 had the highest photocatalytic activity and showed higher photocatalytic efficiency compared with other TiO2-SiO2 composites reported for photodegradation of phenol and MB.
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Hunsberger, Luke, et Roberto Posenato. « Faster Dynamic-Consistency Checking for Conditional Simple Temporal Networks ». Proceedings of the International Conference on Automated Planning and Scheduling 30 (1 juin 2020) : 152–60. http://dx.doi.org/10.1609/icaps.v30i1.6656.
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A Conditional Simple Temporal Network (CSTN) is a structure for representing and reasoning about time in domains where temporal constraints may be conditioned on outcomes of observations made in real time. A CSTN is dynamically consistent (DC) if there is a strategy for executing its time-points such that all relevant constraints will necessarily be satisfied no matter which outcomes happen to be observed. The literature on CSTNs contains only one sound-and-complete DC-checking algorithm that has been implemented and empirically evaluated. It is a graph-based algorithm that propagates labeled constraints/edges. A second algorithm has been proposed, but not evaluated. It aims to speed up DC checking by more efficiently dealing with so-called negative q-loops.This paper presents a new two-phase approach to DC-checking for CSTNs. The first phase focuses on identifying negative q-loops and labeling key time-points within them. The second phase focuses on computing (labeled) distances from each time-point to a single sink node. The new algorithm, which is also sound and complete for DC-checking, is then empirically evaluated against both pre-existing algorithms and shown to be much faster across not only previously published benchmark problems, but also a new set of benchmark problems. The results show that, on DC instances, the new algorithm tends to be an order of magnitude faster than both existing algorithms. On all other benchmark cases, the new algorithm performs better than or equivalently to the existing algorithms.
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Ajmal Ali, Mohammad, Mohammad Tabrez Quasim, Mohammad Abul Farah, Fahad Mohammad Al-Hemaid, Joongku Lee, Khalid Mashay Al-Anazi, Soo Yong Kim et Tapan Pan. « CSTNPD : a database for cancer specific toxic natural products ». Indian Journal of Science and Technology 12, no 10 (1 mars 2019) : 1–5. http://dx.doi.org/10.17485/ijst/2019/v12i10/141396.
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Ma, Yongzheng, Jiangning Chen et Kai Nan. « Global Collaborations in CSTNET ». Proceedings of the Asia-Pacific Advanced Network 37 (7 juin 2014) : 1. http://dx.doi.org/10.7125/apan.37.1.
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Posenato, Roberto. « CSTNU Tool : A Java library for checking temporal networks ». SoftwareX 17 (janvier 2022) : 100905. http://dx.doi.org/10.1016/j.softx.2021.100905.
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Novotný, Vít. « Příprava Zpravodaje CSTUG ». Zpravodaj Československého sdružení uživatelů TeXu 28, no 1-4 (2018) : 1–10. http://dx.doi.org/10.5300/2018-1-4/1.
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Novotný, Vít. « Příprava Zpravodaje CSTUG ». Zpravodaj Československého sdružení uživatelů TeXu 28, no 3-4 (2018) : 1–10. http://dx.doi.org/10.5300/2018-3-4/1.
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Jin, Xiao Ping, Hui Zhen Feng et You Ming Li. « Cooperative Space-Time Network Coding for Multi-Sources Distributed Cooperative Network ». Applied Mechanics and Materials 651-653 (septembre 2014) : 1816–20. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.1816.
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In this paper, a novel cooperation space-time network coding (CSTNC) scheme based on multi-sources distributed cooperative network is considered. In this scheme, multiple sources transmit signals to relay and destination node. The relay re-encodes the decoded signals through space-time network coding with the aid of multiple antennas. The simulation shows that the BER, capacity and outage probability of the CSTNC becomes better with the increasing of relay antenna number and very close to traditional space-time network coding (TCSTC) scheme. Meanwhile, transmission efficiency analysis demonstrates that CSTNC scheme has higher transmission rate.
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Vrabcová, Tereza. « Digital Archival of the CSTUG Bulletin ». Zpravodaj Československého sdružení uživatelů TeXu, no 1 (2022) : 11–17. http://dx.doi.org/10.5300/2022-1-4/11.
Texte intégralThèses sur le sujet "Cstnud"
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BREDA, W. L. « Um Ambiente para Apoio à Tradução Baseado em Conhecimento : Cstudo de Caso com Português-Libras ». Universidade Federal do Espírito Santo, 2008. http://repositorio.ufes.br/handle/10/4059.
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Previous issue date: 2008-02-22Esta dissertação apresenta uma proposta de tradução automática baseada em conhecimento, o projeto e a implementação de um sistema de autoria e uso de tradutores automatizados para apoio à tradução, tendo como estudo de caso a tradução de Português para Libras. Esse sistema possui um ambiente para manipulação dos elementos utilizados no processo de tradução automática e um para tradução automática de textos de uma língua-fonte, em forma de texto, para uma língua-alvo, em forma de texto, vídeo e/ou áudio. Os elementos utilizados no processo de tradução são exemplos de tradução da língua-fonte para a língua-alvo e regras de tradução inferidas considerando esses mesmos exemplos. Para isso, o conteúdo deste trabalho apresenta um estudo sobre tradução automática, apontando seus métodos e, brevemente, seus principais paradigmas, além de uma breve exposição sobre memória de tradução. Apresenta também um estudo sobre a definição de linguagens formais e inferência gramatical, apontando seus métodos e, brevemente, a especificação de problemas de inferência gramatical. Apresenta ainda os algoritmos de tradução e de inferência utilizados pelo sistema, bem como as estruturas de dados necessárias e resultados gerados por eles. Ao longo de todo o conteúdo, é possível observar alguns aspectos de usabilidade, navegabilidade, funcionalidade e complexidade do sistema gerado como produto final deste trabalho, um ambiente de apoio à tradução, baseado em exemplos e sintaxe.
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Mabrouk, Nesrine. « Effet anti-tumoral du GTN +/- doxorubicine dans le cancer du sein triple négatif : implication du système immunitaire ». Thesis, Bourgogne Franche-Comté, 2021. https://nuxeo.u-bourgogne.fr/nuxeo/site/esupversions/1f1d033c-28a0-48c8-a8c4-e49ea46a9f18.
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Le cancer du sein (CS) est une maladie hautement complexe, hétérogène et multifactorielle. Comparé aux autres sous-types, le cancer du sein triple négatif (CSTN) représente l'un des stades les plus avancés de la maladie, et se caractérise par une forte hétérogénéité inter et intra-tumorale et une charge mutationnelle élevée, rendant les traitements très difficiles et inefficaces. L’absence d’expression des récepteurs aux œstrogènes, à la progestérone, et l’absence de surexpression du récepteur HER2, fait des chimiothérapies (exemple : la doxorubicine) adjuvantes ou néo adjuvantes, le traitement de référence chez les patients atteints de ce type de cancer. Malheureusement, le taux de réponse anatomopathologique complète en réponse à ces chimiothérapies, dépasse rarement les 50 % avec un bénéfice à long terme qui touche uniquement 30 à 50% des malades. Le laboratoire LIIC dans lequel j’ai effectué ma thèse a comme objectif de montrer qu’un donneur de monoxyde d’azote (NO), le glycéryl trinitritrate (GTN), médicament utilisé en cardiologie, peut améliorer l’efficacité thérapeutique des chimiothérapies anti-cancéreuses. Le but de mon projet de thèse consistait donc à déterminer si l’association du GTN à la doxorubicine pouvait potentialiser l’activité anti-tumorale de cette chimiothérapie dans le CSTN, et de déterminer le mécanisme par lequel cette combinaison agit en mettant l’accent sur le microenvironnement immunitaire en général, et plus particulièrement sur les cellules myéloïdes immunosuppressives, les MDSCs.Les résultats ont montré que l’association du GTN à la doxorubicine améliorait significativement l'efficacité anti-tumorale de cette dernière, dans un modèle de CSTN induit par l’injection de cellules mammaires 4T1. Cet effet est dû, en partie, à la capacité du GTN à augmenter la différenciation des LTCD4+ vers le sous-type anti-tumorale Th1, à augmenter le recrutement intra-tumoral des cellules CD8+/PD-1+ et des G-MDSCs sous-exprimant PD-L1. Cependant, le mécanisme principal par lequel le GTN agit repose essentiellement sur sa capacité à reprogrammer, en présence des ROS, ces G-MDSCs en faveur d’une diminution de leur activité immunosuppressive. En effet, les résultats ont révélé que le GTN, via la S-nitrosylation de STAT5, était capable de moduler le métabolisme lipidique, dépendant de la protéine FATP2 (Fatty Acid Transport Protein 2) de ces cellules. Ainsi une diminution de FATP2, ainsi que de tous les composants faisant partie de la voie de signalisation de cette protéine, en amont (STAT5) et en aval (PGE2), a été observée en réponse au GTN +/- doxorubicine. Tous ces effets étaient inhibés en présence d’un inhibiteur de ROS, la N-acétyl cystéines (NAC). La NAC retardait également considérablement la progression tumorale lorsqu’elle est associée à la combinaison doxorubicine / GTN.Ce travail, basé sur l’utilisation de deux molécules couramment utilisées en clinique, ouvre sans conteste une nouvelle perspective de traitement pour les patientes atteintes d’un cancer TN et cette combinaison pourra être rapidement proposée aux cliniciensBreast cancer (BC) is a highly complex, heterogeneous and multifactorial disease. Compared to other subtypes, triple negative (TNBC) represents one of the most advanced stages of the disease, and is characterized by a strong inter- and intra-tumor heterogeneity and a high mutational burden, making treatments very difficult and inefficient. The absence of estrogen and progesterone receptors expression, and the absence of HER2 receptor overexpression, makes chemotherapy (example: doxorubicin), the prior treatment in patients with this type of BC. Unfortunately, the complete anatomopathological response rate, in response to these chemotherapies, rarely exceeds 50% with a long-term benefit affecting only 30 to 50% of patients. The LIIC laboratory in which I did my thesis aims to show that a donor of nitric oxide (NO), glyceryl trinitritrate (GTN), a drug used in cardiology, can improve the therapeutic efficacy of anti-cancerous chemotherapy. The aim of my thesis project was therefore to determine whether the association of GTN with doxorubicin could potentiate the antitumor activity of this chemotherapy in TNBC, and to determine the mechanism by which this combination acts by emphasizing the immune microenvironment in general, and more particularly on immunosuppressive myeloid cells, MDSCs.The results showed that the association of GTN with doxorubicin significantly improved the anti-tumor efficacy of this chemotherapy, in a TNBC model induced by the injection of 4T1 breast cells. This effect is due, in part, to the ability of GTN to increase the differentiation of LTCD4 + in the anti-tumor linage Th1, to increase the intra-tumor recruitment of CD8 + / PD-1 + cells and of G-MDSCs down-expressing PD-L1. Nevertheless, the main mechanism by which GTN acts is essentially based on its ability to reprogram, in the presence of ROS, these G-MDSCs towards a less immunosuppressive phenotype. Indeed, the results revealed that GTN, via the S-nitrosylation of STAT5, was able to modulate the lipid metabolism of these cells, which is dependent on the protein FATP2 (Fatty Acid Transport Protein 2). Thus, a decrease in FATP2, as well as all the upstream (STAT5) and downstream (PGE2) components of this signaling pathway was observed in response to GTN +/- doxorubicin. All of these effects were inhibited in the presence of an ROS inhibitor, the N-acetyl cysteines (NAC). NAC also significantly delayed tumor progression when used in combination with doxorubicin / GTN.This work, based on the use of two molecules commonly used in the clinic, undoubtedly opens up a new treatment perspective for patients with TNBC and this combination can quickly be offered to clinicians
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Houhou, Mona. « Caractérisation de sous-populations enrichies en cellules souches cancéreuses et rôle des régulateurs de la transition épithélio-mésenchymateuse dans la plasticité tumorale dans le cancer du sein de type basal ». Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT043.
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Il est généralement admis que le cancer du sein représente un ensemble de plusieurs maladies, définies comme des sous-types ayant des caractéristiques moléculaires et cliniques qui leurs sont propres. Une meilleure compréhension des mécanismes qui sous-tendent l'hétérogénéité du cancer du sein est essentielle au développement de thérapies mieux ajustées. Le concept de cellules souches cancéreuses (CSC) pourrait être un des clés de cette compréhension. A ce jour, un certain nombre de marqueurs ont été proposés pour isoler et caractériser les cellules souches dans le cancer du sein, mais aucun ne semble totalement satisfaisant.Le but de mon travail était de déterminer un marqueur ou une combinaison de marqueurs avec lesquels les fractions enrichies en CSC pourraient être isolées de manière reproductible dans le cancer du sein de sous-types basal (BLBC). En effet, les tumeurs basales représentent 15% de toutes les tumeurs mammaires, mais constituent le sous-type le plus agressif. À cet effet, j'ai analysé un certain nombre de marqueurs par analyse FACS et tri cellulaire et utilisé la capacité de formation de mammosphères (MS) comme critère de validation pour la présence de CSC. Les lignées cellulaires utilisées comme modèles étaient les SUM 159, MDA-MB-231, MDA-MB-436, HCC1143, MDA-MB-468, Hs578T et BT-549 correspondant aux modèles basal-A et B. J'ai également testé trois lignées luminales les MCF7, T47D et BT474.De tous les marqueurs testés, seules, la combinaison des protéines de surface cellulaire CD44/CD24/EpCAM et l’activité enzymatique ALDH élevée ont permis d’obtenir un enrichissement significatif en CSC. Toutefois, le niveau de l'activité ALDH est apparu inconstant d’une lignée cellulaire à une autre et selon le type de tumeurs. D'autres marqueurs membranaires ont donné des résultats mitigés dans le cancer du sein ER-. En effet, la plupart des lignées basales ont montré des profils FACS assez homogènes avec des proportions élevées de cellules CD44+. Cependant, l'association de la positivité de CD44 avec l'EMT et la souchitude, ainsi que la bonne corrélation observée dans les modèles luminaux de la population de cellules CD44+/CD24- avec l’enrichissement en CSC, nous a incité à déterminer si le niveau d'expression en CD44 faisait une différence dans les tumeurs basales. Sur cette base, j’ai montré que les cellules CD44 high présentent une forte capacité à former des MS dans toutes les lignées cellulaires testées. Cette constatation nous a incités à utiliser CD44high vs. CD44low comme critère de tri cellulaire et à utiliser ces fractions pour effectuer une analyse du transcriptome afin d'identifier d'autres marqueurs non encore déterminés, pouvant isoler des fractions cellulaires plus faibles avec un enrichissement plus élevé en CSCIt is now accepted that breast cancer is a compendium of several diseases defined as subtypesthat are associated with different clinical outcomes and molecular characteristics. A betterunderstanding of the mechanisms underlying breast cancer heterogeneity is critical to the development of better adjusted therapies. One of the keys to breast cancer heterogeneity may be explained by cancer stem cells (CSC). A number of markers have been proposed to isolate and characterize breast cancer stem cells, but none appears totally satisfactory.The purpose of my work was determine a marker or combination of markers with which CSC enriched fractions could be reproducibly isolated in basal like breast cancer (BLBC). BLBC represent 15% of all breast tumors, but are the most aggressive subtype. To this aim, I have analyzed a number of markers by FACS analysis and cell sorting and used the capacity to form mammospheres (MS) as a validation criterion for the presence of CSCs. The cell lines used as models were SUM 159, MDA-MB-231, MDA-MB-436, HCC1143, MDA-MB-468, Hs578T and BT-549 comprising both Basal A and Basal B models. I also tested three luminal models MCF7, T47D and BT474.Of all the markers tested those that most consistently allowed enrichment of CSCs were the combination of cell surface proteins CD44/CD24/EpCAM and elevated ALDH enzyme activity. However, ALDH activity appeared irregular, ranging from good to inconsistent according to the cell line. Other cell surface markers gave mixed results in ER- breast cancer because the elevated fraction of CD44+ cells found in most of basal breast cancer cell lines and their propensity to show rather homogenous FACS labeling patterns. However, the association of CD44 positivity with EMT and stemness, as well as the good correlation, we observed in luminal models, of CD44+/CD24- cell population with CSC enrichment incited us to determine whether the level of expression of CD44 could make a difference in basal like models. I show that CD44high cells present higher capacity to form MS in all cell line models tested. This prompted us to use CD44high vs. CD44low as a cell sorting criterion and use these fractions to perform transcriptome analysis in order to identify other markers yet not determined, that may point to smaller cell fractions with a higher CSC enrichment
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Dubois, Clémence. « Optimisation du traitement du cancer du sein Triple-Négatif : développement des modèles de culture cellulaire en trois dimensions, efficacité de l'Olaparib (anti-PARP1) en combinaison avec la radiothérapie et chimiorésistance instaurée par les protéines Multi Drug Résistance ». Thesis, Université Clermont Auvergne (2017-2020), 2018. http://www.theses.fr/2018CLFAS018/document.
Texte intégralRésumé :
Le cancer du sein est une maladie complexe et difficile à caractériser. Parmi les différents sous-types moléculaires, les tumeurs du sein Triple-Négatives (TN) sont particulièrement agressives et de mauvais pronostic. Elles sont caractérisées par une absence d’expression des récepteurs aux œstrogènes (ER), à la progestérone (PR), l’absence de surexpression du récepteur Human Epidermal growth factor 2 (HER2) et de fréquentes mutations sur les gènes BRCA1/2 (profil « BRCAness »). En absence de thérapies ciblées efficaces, de nombreux traitements ciblés notamment les inhibiteurs de poly-ADP-ribose polymérases (anti-PARPs) sont actuellement en cours de développement, en recherche préclinique et clinique. Basés sur le principe de létalité synthétique, les anti-PARPs ciblent les propriétés BRCAness des tumeurs TN. Dans ce contexte, ces travaux de recherche ont été orientés sur le développement d’outils diagnostics afin d’optimiser l’efficacité des anti-PARPs sur des tumeurs TN. Pour ce faire, dans un premier temps, des cultures cellulaires en 3D via la technique Liquid Overlay ainsi que des tests de cytotoxicités associés ont été développés, à partir des lignées cellulaires MDA-MB-231 et SUM1315 de phénotype TN. Ces deux modèles de sphéroïdes ont ensuite été optimisés/normalisés dans un milieu de culture synthétique intitulé OPTIPASS (BIOPASS). Dans un deuxième temps, l’efficacité d’un co-traitement combinant l’anti-PARP1 Olaparib à faibles et à fortes doses et la radiothérapie fractionnée (5x2 Gy) a été modélisée sur les deux lignées MDA-MB-231 et SUM1315, en conditions 2D et 3D. Ces expériences ont clairement mis en évidence un effet potentialisateur de l’Olaparib sur la radiothérapie (i) en présence de faibles doses de cet anti-PARP (5 µM ou inférieur) (ii) à long terme et (iii) en présence d’un fractionnement maximum (5x2 Gy). De plus, les lignées tumorales TN étudiées présentaient des différences de sensibilité vis-à-vis du co-traitement. Ainsi, une analyse transcriptomique in silico a mis en évidence des profils très différents de ces lignées hautement métastatiques et très agressives. Notamment, la lignée SUM1315 semblait présenter un engagement neuronal, suggérant son origine métastatique cérébrale. Ces résultats encourageants pourraient ouvrir de nouvelles perspectives pour le traitement des métastases cérébrales de tumeurs mammaires TN, très fréquentes chez ce sous-type. Dans un troisième temps, afin de mieux caractériser le mode d’action de l’Olaparib sur ces modèles de sphéroïdes, un dérivé fluorescent de l’Olaparib, l’Ola-FL, a été synthétisé et caractérisé. L’analyse de la pénétration et de la distribution de l’Ola-FL au sein des sphéroïdes MDA-MB-231 et SUM1315 a mis en évidence une distribution rapide et homogène du composé ainsi que sa persistance après 3h d’incubation, dans toute la profondeur des sphéroïdes et notamment dans les zones hypoxiques centrales. Enfin, l’analyse de la co-expression de deux pompes Multidrug Resistance (MDR) majeures, la MRP7 et la P-gp après le traitement des deux lignées TN avec l’Olaparib, a mis en évidence sur les cultures 2D, une expression de type relai de la MRP7 et la P-gp. Sur les sphéroïdes traités avec une faible dose d’Olaparib à long terme, une expression basale de la MRP7 et une surexpression de la P-gp ont été détectées, au sein des cellules résiduelles périphériques des sphéroïdes. Ces résultats mettent clairement en évidence l’implication des pompes d’efflux dans les mécanismes de résistances à l’Olaparib, dans ces tumeurs agressives. L’ensemble des résultats issus de la modélisation de l’action de l’Olaparib sur des sphéroïdes MDA-MB-231 et SUM1315 laissent supposer sa plus grande efficacité à faible dose et à long-terme, notamment dans les zones hypoxiques des sphéroïdes, probablement aussi à l’origine de son effet potentialisateur avec la radiothérapieBreast cancer is a very complex and heterogeneous disease. Among the different molecular subtypes, Triple-Negative (TN) breast cancers are particularly aggressive and of poor prognosis. TN tumours are characterized by a lack of estrogen receptors expression (ER), progesterone receptors expression (PR), the absence of Human Epidermal growth factor receptor 2 overexpression (HER2) of the frequent mutations on BRCA1 / 2 genes ("BRCAness" phenotype). In the absence of effective targeted therapies, many targeted therapies including poly-ADP-ribose polymerase inhibitors (anti-PARPs) are currently under development in preclinical and clinical studies. Based on the synthetic lethality concept, the anti-PARPs specifically target the BRCAness properties of TN tumors. In this context, these works were focused on the development of diagnostic tools for the optimization of TN tumours treatment with anti-PARPs. For this, firstly, 3D cell cultures formed with the Liquid Overlay technique as well as associated cytotoxicity tests were developed, from the TN breast cancer cell lines MDA-MB-231 and SUM1315. These two spheroid models were then optimized and standardized in a synthetic culture medium called OPTIPASS (BIOPASS). Secondly, the efficacy of a co-treatment combining anti-PARP1 Olaparib at low and high doses and fractioned radiotherapy (5x2 Gy) was analyzed on the two cell lines MDA-MB-231 and SUM1315 cultured in 2D and 3D conditions. These experiments clearly demonstrated a potentiating effect of Olaparib on radiotherapy (i) in presence of low doses of this anti-PARP (5 μM or inferior) (ii) at long term and (iii) in presence of the maximum fractionation (5x2 Gy). In addition, these two TN cell lines showed a heterogeneous sensitivity to the co-treatment. Thus, an in silico transcriptomic analysis revealed very different profiles of these highly metastatic and highly aggressive cell lines. Notably, the SUM1315 cell line presented a neuronal commitment, suggesting its cerebral metastatic origin. These promising results could open up new perspectives for the treatment of TN tumours brain metastases, which are very common in this subtype. Thirdly, in order to better characterize the mode of action of Olaparib on these spheroid models, a fluorescent derivative of Olaparib, Ola-FL, was synthesized and characterized. The analysis of Ola-FL penetration and distribution in MDA-MB-231 and SUM1315 spheroids showed a rapid and homogeneous distribution of the compound as well as its persistence after 3h of incubation, in all the depth of the spheroids and especially in the central hypoxic zones. Finally, the analysis of the co-expression of two major Multidrug Resistance (MDR) pumps, MRP7 and P-gp after the treatment of the two TN lines with Olaparib, revealed on 2D cultures, a relay type expression of the MRP7 and the P-gp. On spheroids treated with a low dose of Olaparib art long term (10 days), a basal expression of MRP7 and an overexpression of P-gp were detected in the peripheral residual cells of the spheroids. These results clearly highlighted the involvement of these efflux pumps in Olaparib resistance mechanisms, in these aggressive tumors. All the results resulting from the modeling of the action of Olaparib on MDA-MB-231 and SUM1315 spheroids suggest its greater efficacy at low dose and at long-term, especially in the hypoxic zones of the spheroids. This parameter might be probably at the origin of its potentiating effect with radiotherapy
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Zavatteri, Matteo. « Temporal and Resource Controllability of Workflows Under Uncertainty ». Doctoral thesis, 2018. http://hdl.handle.net/11562/979769.
Texte intégralRésumé :
Workflow technology has long been employed for the modeling, validation and execution of business processes. A workflow is a formal description of a business process in which single atomic work units (tasks), organized in a partial order, are assigned to processing entities (agents) in order to achieve some business goal(s). Workflows can also employ workflow paths (projections with respect to a total truth value assignment to the Boolean variables associated to the conditional split connectors) in order (not) to execute a subset of tasks. A workflow management system coordinates the execution of tasks that are part of workflow instances such that all relevant constraints are eventually satisfied. Temporal workflows specify business processes subject to temporal constraints such as controllable or uncontrollable durations, delays and deadlines. The choice of a workflow path may be controllable or not, considered either in isolation or in combination with uncontrollable durations. Access controlled workflows specify workflows in which users are authorized for task executions and authorization constraints say which users remain authorized to execute which tasks depending on who did what. Access controlled workflows may consider workflow paths too other than the uncertain availability of resources (users, throughout this thesis). When either a task duration or the choice of the workflow path to take or the availability of a user is out of control, we need to verify that the workflow can be executed by verifying all constraints for any possible combination of behaviors arising from the uncontrollable parts. Indeed, users might be absent before starting the execution (static resiliency), they can also become so during execution (decremental resiliency) or they can come and go throughout the execution (dynamic resiliency). Temporal access controlled workflows merge the two previous formalisms by considering several kinds of uncontrollable parts simultaneously. Authorization constraints may be extended to support conditional and temporal features. A few years ago some proposals addressed the temporal controllability of workflows by encoding them into temporal networks to exploit "off-the-shelf" controllability checking algorithms available for them. However, those proposals fail to address temporal controllability where the controllable and uncontrollable choices of workflow paths may mutually influence one another. Furthermore, to the best of my knowledge, controllability of access controlled workflows subject to uncontrollable workflow paths and algorithms to validate and execute dynamically resilient workflows remain unexplored. To overcome these limitations, this thesis goes for exact algorithms by addressing temporal and resource controllability of workflows under uncertainty. I provide several new classes of (temporal) constraint networks and corresponding algorithms to check their controllability. After that, I encode workflows into these new formalisms. I also provide an encoding into instantaneous timed games to model static, decremental and dynamic resiliency and synthesize memoryless execution strategies. I developed a few tools with which I carried out some initial experimental evaluations.
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Huang, Po-Chin, et 黃柏欽. « Incorporating a Hole-Transport Material into the Emissive Layer of Solid-State Light-Emitting Electrochemical Cells to Improve Device Performance ». Thesis, 2015. http://ndltd.ncl.edu.tw/handle/cstn6z.
Texte intégralRésumé :
碩士國立交通大學
影像與生醫光電研究所
103
Solid-state light-emitting electrochemical cells (LECs) based on ionic transition metal complexes (iTMCs) have several advantages such as high efficiency, low operation voltage and simple device structure. To improve device efficiency of iTMC-based LECs for practical applications, improving carrier balance to achieve a centered recombination zone would be an important issue. In this work, incorporating a hole-transport material (HTM) into the emissive layer of iTMC-based LECs is shown to improve device performance. When mixed with an HTM (12%), the LECs based on a Ru complex exhibit 1.9X and 1.5X enhancement in peak light output and peak external quantum efficiency (EQE) as compared to neat-film devices. Furthermore, over 2X enhancement in stabilized EQE can be achieved in LECs mixed with an HTM. It is attributed to that more centered recombination zone in LECs mixed with an HTM is beneficial in reducing exciton quenching in the recombination zone approaching extended doped layers. Estimating temporal evolution of recombination zone in the LECs mixed with an HTM by employing microcavity effect is demonstrated to confirm the physical origin for improved device performance. These results reveal that incorporaing of an HTM in the emissive layer of LECs based on an iTMC is a feasible way to improve carrier balance and thus enhances light output and device efficiency.
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Lee, Chien-te, et 李建德. « CSTN LCD Frame Rate Controller For Image Quality Enhancement ». Thesis, 2010. http://ndltd.ncl.edu.tw/handle/08194971132122979072.
Texte intégralRésumé :
碩士國立中山大學
電機工程學系研究所
98
This thesis is mainly focused on FRC (Frame Rate Control) method which can be used for LCD panels, where a new algorithm is proposed to improve the flicker problem. The proposed algorithm can be implemented by simple digital circuits with low power consumption. The proposed design can be applied in both mono- and color- STN panels. It can generate 32768 colors in a panel without any flicker and motion line problems, which can only allow 8 colors originally. The major contribution in this thesis is to add a location number to each pixel of the panel.Notably, the numbers for all the pixels can not be a regular pattern. Otherwise, the flicker problem is resolved at the expense of a serious motion line issue. The consequence is poor display quality. To resolve both the flicker and motion line problem, we propose to employ a PRSG (Pseudo Random Sequence Generator) which generates a non-regular number sequence for all the pixels. Therefore, all the ON pixels can be dispersed on the panel in all frames.
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Su, Meng-kuan, et 蘇孟冠. « Logistics System Design For Two-Stage Manufacturing --A Case Study In CSTN Firm ». Thesis, 2006. http://ndltd.ncl.edu.tw/handle/72308743986899806161.
Texte intégralRésumé :
碩士逢甲大學
經營管理碩士在職專班
94
Due to the considerations of cost, market, environment and other factors, many manufacturing enterprises decompose successive production flows into stage-production model, which are located in many countries, to take advantages of regional manufacturing. However, a firm can’t utilize a single production model through the whole production flow in different sites because of the conditions of culture, political issues, government policies, labor loyalty and manufacturing environment. Under variable production conditions, the logistical system for two-stage manufacturing has become complex and more operational risks needs to be solved. This research aims to develop a robust logistics system to support two-stage manufacture models. The proposed approach applies main ideas of Vendor-Managed Inventory (VMI) such as warehouse management, customer management, supplier management, distribution method and Electronic Data Interchange (EDI) to constructing the logistics system. The system is designed to integrate pull and push productions into a lean-like manufacturing model. A real case regarding to a Liquid Crystal Display (LCD) manufacturer is demonstrated the proposed VMI-based logistics system. Implementation strategy and suggestions are also discussed and summarized. The research results show that the system integrate various production models effectively and manage inventory more efficient and then reducing total manufacturing cost.
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Chen, Shih-Bin, et 陳世斌. « Influence on the vision of different Frame Rate Control methods on CSTN panel ». Thesis, 2009. http://ndltd.ncl.edu.tw/handle/57362009431658652635.
Texte intégralRésumé :
碩士雲林科技大學
電子與資訊工程研究所
97
Color super-twist nematic (CSTN) LCD panel is widely used in mobile handset and consumer device. The frame rate control (FRC) is designed to improve the colors levels of color LCD panel. However, the typical FRC display method is easy to cause the flicker and motion artifact questions in the vision and the image defect caused of crosstalk. This thesis compares and analyzes column alternation, pixel alternation, and normal FRC control methods under the different color and the gray-level, its influence on the human eye vision.
Livres sur le sujet "Cstnud"
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Kokuritsu Kokkai Toshokan (Japan). Kansaikan, dir. Ajia e no chiteki tankyū to toshokan sābisu no shintenkai : Shinpojūmu kirokushū. Kyōto-fu Sōraku-gun Seika-chō : Kokuritsu Kokkai Toshokan, 2004.
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Jiachi, Yang, International Federation of Automatic Control. et International Federation of Operational Research Societies., dir. Control science and technology for development (CSTD'85) : Proceedings of the IFAC/IFORS Symposium, Beijing, People's Republic of China, 20-22 August 1985. Oxford : Published for the International Federation of Automatic Control by Pergamon, 1986.
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IFAC/IFORS, Symposium on Control Science and Technology for Development (1985 Beijing China). Control science and technology for development (CSTD'85) : Proceedings of the IFAC/IFORS Symposium, Beijung, People's Republic of China, 20-22 August 1985. Oxford [Oxfordshire] : Published for the International Federation of Automatic Control by Pergamon Press, 1986.
Trouver le texte intégralActes de conférences sur le sujet "Cstnud"
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Liu, Jiawei, Zheng-Jun Zha, Xierong Zhu et Na Jiang. « Co-Saliency Spatio-Temporal Interaction Network for Person Re-Identification in Videos ». Dans Twenty-Ninth International Joint Conference on Artificial Intelligence and Seventeenth Pacific Rim International Conference on Artificial Intelligence {IJCAI-PRICAI-20}. California : International Joint Conferences on Artificial Intelligence Organization, 2020. http://dx.doi.org/10.24963/ijcai.2020/141.
Texte intégralRésumé :
Person re-identification aims at identifying a certain pedestrian across non-overlapping camera networks. Video-based person re-identification approaches have gained significant attention recently, expanding image-based approaches by learning features from multiple frames. In this work, we propose a novel Co-Saliency Spatio-Temporal Interaction Network (CSTNet) for person re-identification in videos. It captures the common salient foreground regions among video frames and explores the spatial-temporal long-range context interdependency from such regions, towards learning discriminative pedestrian representation. Specifically, multiple co-saliency learning modules within CSTNet are designed to utilize the correlated information across video frames to extract the salient features from the task-relevant regions and suppress background interference. Moreover, multiple spatial-temporal interaction modules within CSTNet are proposed, which exploit the spatial and temporal long-range context interdependencies on such features and spatial-temporal information correlation, to enhance feature representation. Extensive experiments on two benchmarks have demonstrated the effectiveness of the proposed method.
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Yang, Xin, Ying Wang, Haishun Chen et Jie Li. « CSTNET : Enhancing Global-To-Local Interactions for Image Captioning ». Dans 2022 IEEE International Conference on Image Processing (ICIP). IEEE, 2022. http://dx.doi.org/10.1109/icip46576.2022.9897810.
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Hunsberger, Luke, et Roberto Posenato. « Simpler and Faster Algorithm for Checking the Dynamic Consistency of Conditional Simple Temporal Networks ». Dans Twenty-Seventh International Joint Conference on Artificial Intelligence {IJCAI-18}. California : International Joint Conferences on Artificial Intelligence Organization, 2018. http://dx.doi.org/10.24963/ijcai.2018/184.
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Recent work on Conditional Simple Temporal Networks (CSTNs) has focused on checking the dynamic consistency (DC) property assuming that execution strategies can react instantaneously to observations. Three alternative semantics---IR-DC, 0-DC, and π-DC---have been presented. The most practical DC-checking algorithm for CSTNs has only been analyzed with respect to the IR-DC semantics, while the 0-DC semantics was shown to have a serious flaw that the π-DC semantics fixed. Whether the IR-DC semantics had the same flaw and, if so, what the consequences would be for the DC-checking algorithm remained open questions. This paper (1) shows that the IR-DC semantics is also flawed; (2) shows that one of the constraint-propagation rules from the IR-DC-checking algorithm is not sound with respect to the IR-DC semantics; (3) presents a simpler algorithm, called the π-DC-checking algorithm; (4) proves that it is sound and complete with respect to the π-DC semantics; and (5) empirically evaluates the new algorithm.
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Homes, J. E. « A development of reference models for computer systems ». Dans 1988 Computer Standards Evolution : Impact and Imperatives. IEEE, 1988. http://dx.doi.org/10.1109/cstand.1988.4765.
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« Proceedings of the Computer Standards Conference 1988 - Computer Standards Evolution : Impact and Imperatives (Cat. No.88CH2549-4) ». Dans 1988 Computer Standards Evolution : Impact and Imperatives. IEEE, 1988. http://dx.doi.org/10.1109/cstand.1988.4771.
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McGarry, F. E. « Using software metrics and measurements to improve software productivity and quality ». Dans 1988 Computer Standards Evolution : Impact and Imperatives. IEEE, 1988. http://dx.doi.org/10.1109/cstand.1988.4775.
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Carrascal, Jorge, Javier Castilla, Juan C. Oller et Jose M. Perez. « Readout electronics setup for the CSTD project ». Dans 2008 IEEE Nuclear Science Symposium and Medical Imaging conference (2008 NSS/MIC). IEEE, 2008. http://dx.doi.org/10.1109/nssmic.2008.4775195.
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Yi, Qingming, et Jing Zhang. « The design and implementation of follower for CSTN-LCD driver ». Dans 2009 ISECS International Colloquium on Computing, Communication, Control, and Management (CCCM). IEEE, 2009. http://dx.doi.org/10.1109/cccm.2009.5268095.
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Song, Guocong, Kenneth Stewart, Robert Love, Xiangyang Zhuang et Yakun Sun. « Asymptotic Performance of Broadcast Services in IEEE 802.16e with CSTD ». Dans IEEE Vehicular Technology Conference. IEEE, 2006. http://dx.doi.org/10.1109/vtcf.2006.162.
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Levy, Marc A. « 1606c The present and future need of closed system transfer devices (cstd) ». Dans 32nd Triennial Congress of the International Commission on Occupational Health (ICOH), Dublin, Ireland, 29th April to 4th May 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/oemed-2018-icohabstracts.937.
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