Littérature scientifique sur le sujet « CRISPR spacers »
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Articles de revues sur le sujet "CRISPR spacers"
Horvath, Philippe, Dennis A. Romero, Anne-Claire Coûté-Monvoisin, Melissa Richards, Hélène Deveau, Sylvain Moineau, Patrick Boyaval, Christophe Fremaux et Rodolphe Barrangou. « Diversity, Activity, and Evolution of CRISPR Loci in Streptococcus thermophilus ». Journal of Bacteriology 190, no 4 (7 décembre 2007) : 1401–12. http://dx.doi.org/10.1128/jb.01415-07.
Texte intégralToro, Magaly, Guojie Cao, Wenting Ju, Marc Allard, Rodolphe Barrangou, Shaohua Zhao, Eric Brown et Jianghong Meng. « Association of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) Elements with Specific Serotypes and Virulence Potential of Shiga Toxin-Producing Escherichia coli ». Applied and Environmental Microbiology 80, no 4 (13 décembre 2013) : 1411–20. http://dx.doi.org/10.1128/aem.03018-13.
Texte intégralAchigar, Rodrigo, Martina Scarrone, Geneviève M. Rousseau, Cécile Philippe, Felipe Machado, Valentina Duvós, María Pía Campot et al. « Ectopic Spacer Acquisition in Streptococcus thermophilus CRISPR3 Array ». Microorganisms 9, no 3 (1 mars 2021) : 512. http://dx.doi.org/10.3390/microorganisms9030512.
Texte intégralvan der Ploeg, Jan R. « Analysis of CRISPR in Streptococcus mutans suggests frequent occurrence of acquired immunity against infection by M102-like bacteriophages ». Microbiology 155, no 6 (1 juin 2009) : 1966–76. http://dx.doi.org/10.1099/mic.0.027508-0.
Texte intégralSerbanescu, M. A., M. Cordova, K. Krastel, R. Flick, N. Beloglazova, A. Latos, A. F. Yakunin, D. B. Senadheera et D. G. Cvitkovitch. « Role of the Streptococcus mutans CRISPR-Cas Systems in Immunity and Cell Physiology ». Journal of Bacteriology 197, no 4 (8 décembre 2014) : 749–61. http://dx.doi.org/10.1128/jb.02333-14.
Texte intégralPavlova, Yekaterina S., David Paez-Espino, Andrew Yu Morozov et Ilya S. Belalov. « Searching for fat tails in CRISPR-Cas systems : Data analysis and mathematical modeling ». PLOS Computational Biology 17, no 3 (26 mars 2021) : e1008841. http://dx.doi.org/10.1371/journal.pcbi.1008841.
Texte intégralDeveau, Hélène, Rodolphe Barrangou, Josiane E. Garneau, Jessica Labonté, Christophe Fremaux, Patrick Boyaval, Dennis A. Romero, Philippe Horvath et Sylvain Moineau. « Phage Response to CRISPR-Encoded Resistance in Streptococcus thermophilus ». Journal of Bacteriology 190, no 4 (7 décembre 2007) : 1390–400. http://dx.doi.org/10.1128/jb.01412-07.
Texte intégralBolotin, Alexander, Benoit Quinquis, Alexei Sorokin et S. Dusko Ehrlich. « Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin ». Microbiology 151, no 8 (1 août 2005) : 2551–61. http://dx.doi.org/10.1099/mic.0.28048-0.
Texte intégralHeussler, Gary E., Jon L. Miller, Courtney E. Price, Alan J. Collins et George A. O'Toole. « Requirements for Pseudomonas aeruginosa Type I-F CRISPR-Cas Adaptation Determined Using a Biofilm Enrichment Assay ». Journal of Bacteriology 198, no 22 (29 août 2016) : 3080–90. http://dx.doi.org/10.1128/jb.00458-16.
Texte intégralLopatina, Anna, Sofia Medvedeva, Daria Artamonova, Matvey Kolesnik, Vasily Sitnik, Yaroslav Ispolatov et Konstantin Severinov. « Natural diversity of CRISPR spacers of Thermus : evidence of local spacer acquisition and global spacer exchange ». Philosophical Transactions of the Royal Society B : Biological Sciences 374, no 1772 (25 mars 2019) : 20180092. http://dx.doi.org/10.1098/rstb.2018.0092.
Texte intégralThèses sur le sujet "CRISPR spacers"
Medvedeva, Sofia. « Natural Diversity of CRISPR Spacers ». Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS538.
Texte intégralCRISPR-Cas is a prokaryotic immunity system against mobile genetic elements, such as viruses and plasmids. The system consists of two components: the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas). In the CRISPR array, short fragments of foreign DNA, called spacers, are interleaved with palindromic repeats. During the adaptation stage of the CRISPR-Cas immunity, new spacers are inserted into the CRISPR array, whereas during the expression and interference stages, spacers are transcribed, processed and complexed with Cas proteins to target the complementary foreign DNA or RNA molecules for degradation. Analysis of CRISPR spacers is a valuable source of information about virus-host interactions, particularly powerful when applied to metagenomic data. In this work, we explored the diversity of CRISPR spacers in different natural prokaryotic communities, including extinct Escherichia coli community from a mammoth intestine, Flavobacterium communities from Antarctic surface snow, Thermus communities from four distant hot springs in Italy and Chile, and Sulfolobales community from a Japanese thermal field. The comparison of obtained environmental spacer sets with each other and with spacers from public databases as well as with sequences of viruses allowed us to reach several non-trivial conclusions and to gain insights into virus-host and virus-virus interactions in natural microbial communities
Vyhovskyi, Danylo. « In vivo studies of CRISPR adaptation mechanism and specificity ». Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS729.
Texte intégralThis thesis investigates the mechanisms of the CRISPR-Cas adaptive immunity in prokaryotes, primarily using the type I-E system in Escherichia coli, focusing on the spacer acquisition process and the system's specificity. It sheds light on the dynamics of spacers generation and integration into CRISPR arrays, comparing naive and primed adaptation modes. The study reveals that a particular PAM (protospacer adjacent motif) - proximal sequence impedes spacer acquisition in the primed mode, providing a distinct identifier for naturally acquired spacers. The study further reveals the role of non-Cas enzymes, linked to DNA repair pathways, in spacer generation and processing, contributing to CRISPR adaptation and interference.Another course of the study identifies potential hazards posed by off-target effects caused by Cas9 (dCas9) RNA-guided enzyme that can inadvertently silence genes. This occurs when there's a minimal match of just four nucleotides between the gRNA and the target within the PAM-proximal sequence, emphasizing the need for careful experimental design in CRISPR-Cas research.Overall, the thesis expands understanding of the complex molecular mechanisms behind CRISPR adaptation, highlighting the role of non-Cas proteins and the significance of a specific genetic context of seed sequences, leading to the development of more precise and efficient genetic engineering tools
Jacot-Guillarmod, Paul. « Sobriety of crisp and fuzzy topological spaces ». Thesis, Rhodes University, 2004. http://hdl.handle.net/10962/d1005228.
Texte intégralStens, Cassandra, Isabella Enoksson et Sara Berggren. « The CRISPR-Cas system ». Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171997.
Texte intégralWong, Shi Pey. « Analysis of the adaptation mechanism in the type II-A CRISPR-Cas system ». Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19806.
Texte intégralThe RNA guided adaptive immune system CRISPR (clustered regularly interspaced short palindromic repeats) Cas (CRISPR-associated) immunizes prokaryotic cells against mobile genetic elements (MGEs). During spacer acquisition stage, a short nucleic acid sequence (prespacer) is acquired from the MGEs, processed and finally integrated into the CRISPR array as a spacer, which serves as genetic memory to defend against the invasion of the cognate MGEs. The molecular mechanism for the spacer acquisition of the type II A systems, which encode cas9, cas1, cas2, csn2 and tracrRNA, is still not fully understood. Therefore, we investigated the requirement of the different Cas proteins for spacer acquisition. We verified the acquisition activity of the type II A systems of Streptococcus thermophilus LMD 9 via spacer acquisition studies by phage challenge. We observed higher acquisition rates in the CRISPR3 locus compared to the CRISPR1 locus. Our plasmid-based spacer acquisition study confirmed in addition to Cas1, Cas2 and Csn2 the requirement of Cas9 for spacer acquisition. Yeast two hybrid and pull down approaches revealed specific interactions among the Cas proteins, as well as interactions between Cas and DNA repair proteins. The interaction regions of Cas1 with Cas9 were identified by SPOT peptide assay. Altogether, our study suggests that Cas proteins interact with proteins within and beyond the CRISPR Cas systems, and it provides a basis for the investigation of the potential roles of DNA repair proteins in the CRISPR Cas systems and/or vice versa.
Hille, Frank [Verfasser]. « Investigation of Spacer Acquisition Mechanisms in Type V-A CRISPR-Cas Systems / Frank Hille ». Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1215570341/34.
Texte intégralRibeiro, Mateus Cotta. « A reprodução crítica do espaço na porção meridional da Serra do Espinhaço de Minas Gerais : modernização do espaço e crise da sociedade do trabalho ». Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/8/8136/tde-15012016-135253/.
Texte intégralThis study deals with the social changes experienced by people from the southern area of Serra do Espinhaço, Minas Gerais, Brazil. These changes are related to the increase of the tourism industry however they are determined by crise o work society reproduction.
Cruz, Murilo Medici Navarro da. « Estado, espaço e acumulação na crise contemporânea ». Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/8/8136/tde-20062007-153251/.
Texte intégralThis work starts from a matter put by the current reality: The world economic crisis, specially seem on what has been denominated \"money predomination economy\" and, along with the crisis, the one of national State, both seen under the world\'s perspective and, equally, the Brazilian perspective. Nevertheless, this work does not intend, herein, to give a historical or purely economic treatment of the problem. Instead, what you will see is closer to an analytical and theoretical exercise. This work constitutes, firstly, of a deep discussion about the basis of capital economy which, according to what is understood, also are the basis of the current economic crisis. Secondly, to reflect about the economic crisis as much as politics, is necessary to reflect about the production of space and the State\'s role within the capitalist society. And thirdly, the union between the State and the capital shows itself identifiable on the national territory analysis along with your basis. Last but not least, the current crisis problem is put through a criticism to the lack of focusing the capital on a specific market, criticism that takes us to formulate the hypothesis of an abstract investment of capital, which would be a characteristic of the crisis itself.
Philipp, Carolin [Verfasser]. « Spaces of Resistance – Framing Crisis and Activism in Athens / Carolin Philipp ». Kassel : Universitätsbibliothek Kassel, 2018. http://d-nb.info/1155948718/34.
Texte intégralKreston, Nicholas Alexander. « Post-Keynesian financial spaces, places, and flows : geographies of finance and financial crisis ». Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:3ea77af2-650c-456a-a4c2-5ee67c83d293.
Texte intégralLivres sur le sujet "CRISPR spacers"
Martin, David. Crisis in space. New York : Ballantine Books, 1986.
Trouver le texte intégralCorporation, British Broadcasting, dir. Crisis in space. London : Severn House by arrangement with the British Broadcasting Corporation, 1986.
Trouver le texte intégralHolt, Michael. Crisis in space. New York : Ballantine Books, 1986.
Trouver le texte intégralill, Kinsella Pat, dir. Crisis. Minneapolis, MN : Magic Wagon, 2017.
Trouver le texte intégralNansen, Ralph. Energy crisis : Solution from space. Burlington, Ont : Apogee Books, 2009.
Trouver le texte intégralReis, Ronald A. Apollo 13 : Crisis in space. New York : Chelsea House, 2012.
Trouver le texte intégralVitalidad y crisis en los espacios públicos de Sevilla. [Seville] : Diputación de Sevilla, 2006.
Trouver le texte intégralCabannes, Yves, Mike Douglass et Rita Padawangi, dir. Cities in Asia by and for the People. NL Amsterdam : Amsterdam University Press, 2018. http://dx.doi.org/10.5117/9789462985223.
Texte intégralMaking Humanitarian Spaces Global : Coordinating Crisis Response through the Cluster Approach. [New York, N.Y.?] : [publisher not identified], 2012.
Trouver le texte intégralBouma, Geiske. Ruimtelijke ordening in crisis : Bijdragen aan de PlanDag 2010. Delft] : [Stichting Planologische Discussiedagen], 2010.
Trouver le texte intégralChapitres de livres sur le sujet "CRISPR spacers"
Davison, Michelle, et Devaki Bhaya. « Creation and Analysis of a Virome : Using CRISPR Spacers ». Dans Methods in Molecular Biology, 307–16. New York, NY : Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9_20.
Texte intégralDupuis, Marie-Ève, Rodolphe Barrangou et Sylvain Moineau. « Procedures for Generating CRISPR Mutants with Novel Spacers Acquired from Viruses or Plasmids ». Dans Methods in Molecular Biology, 195–222. New York, NY : Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9_13.
Texte intégralPallarés, Ana Morcillo. « Crisis and opportunity ». Dans Manhattan's Public Spaces, 61–69. London : Routledge, 2021. http://dx.doi.org/10.4324/9781003198543-4.
Texte intégralMokrousov, Igor, et Nalin Rastogi. « Spacer-Based Macroarrays for CRISPR Genotyping ». Dans Methods in Molecular Biology, 111–31. New York, NY : Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2687-9_7.
Texte intégralBurman, Erica. « Lockdown Vistas : Time, Space, Solidarity, Action ». Dans The Psychology of Global Crises and Crisis Politics, 189–212. Cham : Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76939-0_9.
Texte intégralJones, Martin, et Kevin Ward. « Excavating the Logic of British Urban Policy : Neoliberalism as the “Crisis of Crisis-Management” ». Dans Spaces of Neoliberalism, 126–47. Chichester, UK : John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9781444397499.ch6.
Texte intégralPallarés, Ana Morcillo. « Identity crisis : Lincoln Center and the High Line ». Dans Manhattan's Public Spaces, 144–69. London : Routledge, 2021. http://dx.doi.org/10.4324/9781003198543-9.
Texte intégralMartín-Moruno, Dolores. « Crisis ? What Crisis ? Making Humanitarian Crises Visible in the History of Emotions ». Dans Making Humanitarian Crises, 1–28. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-00824-5_1.
Texte intégralGouw, Arvin M. « CRISPR Challenges and Opportunities for Space Travel ». Dans Human Enhancements for Space Missions, 19–34. Cham : Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-42036-9_2.
Texte intégralMaciocco, Giovanni, et Silvano Tagliagambe. « The Aesthetic Crisis as the Crisis of the Glance ». Dans People and Space, 13–18. Dordrecht : Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-9879-6_3.
Texte intégralActes de conférences sur le sujet "CRISPR spacers"
Timkin, P. D., et A. A. Penzin. « An experimental approach for diagnosing cercosporosis using RPA+CRISPR/Cas12a ». Dans II All-Russian (national) scientific conference with international participation "Russian Science, Innovation, Education". Krasnoyarsk Science and Technology City Hall, 2023. http://dx.doi.org/10.47813/rosnio-ii.2023.8.263-266.
Texte intégralPernak, Elizaveta, Mariia Vladimirova, Viktoria Muntyan, Alexey Afonin et Marina Roumiantseva. « ANALYSIS OF CRISPR CASSETTE ELEMENTS IN NATIVE ISOLATES OF SINORHIZOBIUM MELILOTI ISOLATED IN THE CENTRAL ASIAN ORIGIN OF PLANT DIVERSITY ». Dans 23rd SGEM International Multidisciplinary Scientific GeoConference 2023. STEF92 Technology, 2023. http://dx.doi.org/10.5593/sgem2023/6.1/s25.13.
Texte intégralMuhlbauer, Rachel L., Kristen Turner, Finn Hiatt, Robert Dyer, Jeff Slostad et Robert P. Hoyt. « CRISSP : Customizable, Recyclable Launch Packaging ». Dans AIAA SPACE 2016. Reston, Virginia : American Institute of Aeronautics and Astronautics, 2016. http://dx.doi.org/10.2514/6.2016-5243.
Texte intégralTsafoulia, Loukia, et Severino Alfonso. « Transient Spaces : Building Community in Crisis Contexts ». Dans 2018 ACSA International Conference. ACSA Press, 2018. http://dx.doi.org/10.35483/acsa.intl.2018.1.
Texte intégralBaryshev, Yurij. « Physics of Gravitational Interaction : Geometry of Space or Quantum Field in Space ». Dans 1st CRISIS IN COSMOLOGY CONFERENCE, CCC-1. AIP, 2006. http://dx.doi.org/10.1063/1.2189130.
Texte intégralWu, Wei-Zhi, et You-Hong Xu. « Rough approximations of intuitionistic fuzzy sets in crisp approximation spaces ». Dans 2010 Seventh International Conference on Fuzzy Systems and Knowledge Discovery (FSKD). IEEE, 2010. http://dx.doi.org/10.1109/fskd.2010.5569662.
Texte intégralStranix, Katie. « Building Resiliency Through Small Scale Restorative Spaces ». Dans 2022 AIA/ACSA Intersections Research Conference. ACSA Press, 2022. http://dx.doi.org/10.35483/acsa.aia.inter.22.12.
Texte intégralTsafoulia, Loukia. « Transient Spaces : Building Community in Crisis Contexts Project ». Dans 2018 ACSA International Conference. ACSA Press, 2018. http://dx.doi.org/10.35483/acsa.intl.2018.2.
Texte intégralBachtarzi, Rym Mouni, Djamel Alkama et Hana Salah-Salah. « Urban Public Space in The Context of a New Era, Case of Annaba City-Algeria ». Dans 4th International Conference of Contemporary Affairs in Architecture and Urbanism – Full book proceedings of ICCAUA2020, 20-21 May 2021. Alanya Hamdullah Emin Paşa University, 2021. http://dx.doi.org/10.38027/iccaua2021199n3.
Texte intégralLasmane, Skaidrīte. « Including the Emotional Potential of Literature in Post-crisis Education ». Dans 80th International Scientific Conference of the University of Latvia. University of Latvia Press, 2022. http://dx.doi.org/10.22364/htqe.2022.73.
Texte intégralRapports d'organisations sur le sujet "CRISPR spacers"
Castilleja Vargas, Liliana, Daniel Hernaiz, Alejandro Rasteletti et Eduardo Borensztein. International Crises and Policy Responses in the Southern Cone. Inter-American Development Bank, octobre 2012. http://dx.doi.org/10.18235/0011434.
Texte intégralMolloy, James P. Air and Space Expeditionary Force Crisis Action Leadership for Commanders. Fort Belvoir, VA : Defense Technical Information Center, avril 2004. http://dx.doi.org/10.21236/ada434089.
Texte intégralCuerden, Richard, Mary Williams, Jeanne Breen, Dan Campsal, Suzy Charman, David G. Davies, Nick Reed et Sarah Simpson. Safe Roads for All. TRL, août 2021. http://dx.doi.org/10.58446/ohss3066.
Texte intégralRebucci, Alessandro, Andrew Powell et Eduardo Fernández-Arias. The Multilateral Response to the Global Crisis : Rationale, Modalities, and Feasibility. Inter-American Development Bank, juin 2009. http://dx.doi.org/10.18235/0010916.
Texte intégralRomer, Christina, et David Romer. Fiscal Space and the Aftermath of Financial Crises : How It Matters and Why. Cambridge, MA : National Bureau of Economic Research, avril 2019. http://dx.doi.org/10.3386/w25768.
Texte intégralAbed, Dana, Rihab Sawaya et Nadim Tabbal. Analyzing Voter Turnout in Lebanon : Political Change in Times of Crisis. Oxfam, avril 2022. http://dx.doi.org/10.21201/2022.8823.
Texte intégralSobhy, Hania. Reforms for Another Planet : The Global Learning Crisis, Political Drivers and Expert Views on Egypt’s Edu 2.0. Research on Improving Systems of Education (RISE), février 2023. http://dx.doi.org/10.35489/bsg-rise-2023/pe06.
Texte intégralTrapani, Paola. Collaborative Housing as a Response to the Housing Crisis in Auckland. Unitec ePress, juillet 2018. http://dx.doi.org/10.34074/ocds.0821.
Texte intégralMontiel, Peter J., et Eduardo Fernández-Arias. Crisis Response in Latin America : Is the "Rainy Day" at Hand ? Inter-American Development Bank, juin 2009. http://dx.doi.org/10.18235/0010915.
Texte intégralBonomo, Marco, Claudio R. Frischtak et Paulo Ribeiro. Public Investment and Fiscal Crisis in Brazil : Finding Culprits and Solutions. Inter-American Development Bank, avril 2021. http://dx.doi.org/10.18235/0003199.
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