Littérature scientifique sur le sujet « CRISPR, Cas9, genome editing, gRNA »
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Articles de revues sur le sujet "CRISPR, Cas9, genome editing, gRNA"
Jo, Areum, Sangwoo Ham, Gum Hwa Lee, Yun-Il Lee, SangSeong Kim, Yun-Song Lee, Joo-Ho Shin et Yunjong Lee. « Efficient Mitochondrial Genome Editing by CRISPR/Cas9 ». BioMed Research International 2015 (2015) : 1–10. http://dx.doi.org/10.1155/2015/305716.
Texte intégralXie, Kabin, Bastian Minkenberg et Yinong Yang. « Boosting CRISPR/Cas9 multiplex editing capability with the endogenous tRNA-processing system ». Proceedings of the National Academy of Sciences 112, no 11 (2 mars 2015) : 3570–75. http://dx.doi.org/10.1073/pnas.1420294112.
Texte intégralMekler, Vladimir, Konstantin Kuznedelov et Konstantin Severinov. « Quantification of the affinities of CRISPR–Cas9 nucleases for cognate protospacer adjacent motif (PAM) sequences ». Journal of Biological Chemistry 295, no 19 (1 avril 2020) : 6509–17. http://dx.doi.org/10.1074/jbc.ra119.012239.
Texte intégralBruegmann, Tobias, Khira Deecke et Matthias Fladung. « Evaluating the Efficiency of gRNAs in CRISPR/Cas9 Mediated Genome Editing in Poplars ». International Journal of Molecular Sciences 20, no 15 (24 juillet 2019) : 3623. http://dx.doi.org/10.3390/ijms20153623.
Texte intégralWardhani, Bantari W. K., Meidi U. Puteri, Yukihide Watanabe, Melva Louisa, Rianto Setiabudy et Mitsuyasu Kato. « TMEPAI genome editing in triple negative breast cancer cells ». Medical Journal of Indonesia 26, no 1 (16 mai 2017) : 14–8. http://dx.doi.org/10.13181/mji.v26i1.1871.
Texte intégralKong, Qihui, Jie Li, Shoudong Wang, Xianzhong Feng et Huixia Shou. « Combination of Hairy Root and Whole-Plant Transformation Protocols to Achieve Efficient CRISPR/Cas9 Genome Editing in Soybean ». Plants 12, no 5 (23 février 2023) : 1017. http://dx.doi.org/10.3390/plants12051017.
Texte intégralJameel, Mohd Rizwan. « From design to validation of CRISPR/gRNA primers towards genome editing ». Bioinformation 18, no 5 (31 mai 2022) : 471–77. http://dx.doi.org/10.6026/97320630018471.
Texte intégralJung, Soo Bin, Chae young Lee, Kwang-Ho Lee, Kyu Heo et Si Ho Choi. « A cleavage-based surrogate reporter for the evaluation of CRISPR–Cas9 cleavage efficiency ». Nucleic Acids Research 49, no 15 (4 juin 2021) : e85-e85. http://dx.doi.org/10.1093/nar/gkab467.
Texte intégralForeman, Hui-Chen Chang, Varvara Kirillov, Gabrielle Paniccia, Demetra Catalano, Trevor Andrunik, Swati Gupta, Laurie T. Krug et Yue Zhang. « RNA-guided gene editing of the murine gammaherpesvirus 68 genome reduces infectious virus production ». PLOS ONE 16, no 6 (4 juin 2021) : e0252313. http://dx.doi.org/10.1371/journal.pone.0252313.
Texte intégralYoo, Byung-Chun, Narendra S. Yadav, Emil M. Orozco et Hajime Sakai. « Cas9/gRNA-mediated genome editing of yeast mitochondria and Chlamydomonas chloroplasts ». PeerJ 8 (6 janvier 2020) : e8362. http://dx.doi.org/10.7717/peerj.8362.
Texte intégralThèses sur le sujet "CRISPR, Cas9, genome editing, gRNA"
Roidos, Paris. « Genome editing with the CRISPR Cas9 system ». Thesis, KTH, Skolan för bioteknologi (BIO), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-163694.
Texte intégralRan, Fei Ann. « CRISPR-Cas : Development and applications for mammalian genome editing ». Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11610.
Texte intégralHirosawa, Moe. « Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch ». Kyoto University, 2019. http://hdl.handle.net/2433/242421.
Texte intégralCastanon, velasco Oscar. « Targeting the transposable elements of the genome to enable large-scale genome editing and bio-containment technologies ». Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX006.
Texte intégralProgrammable and site-specific nucleases such as CRISPR-Cas9 have started a genome editing revolution, holding hopes to transform human health. Multiplexing or the ability to simultaneously introduce many distinct modifications in the genome will be required for basic and applied research. It will help to probe the physio-pathological functions of complex genetic circuits and to develop improved cell therapies or anti-viral treatments. By pushing the boundaries of genome engineering, we may reach a point where writing whole mammalian genomes will be possible. Such a feat may lead to the generation of virus-, cancer- or aging- free cell lines, universal donor cell therapies or may even open the way to de-extinction. In this doctoral research project, I outline the current state-of-the-art of multiplexed genome editing, the current limits and where such technologies could be headed in the future. We leveraged this knowledge as well as the abundant transposable elements present in our DNA to build an optimization pipeline and develop a new set of tools that enable large-scale genome editing. We achieved a high level of genome modifications up to three orders of magnitude greater than previously recorded, therefore paving the way to mammalian genome writing. In addition, through the observation of the cytotoxicity generated by multiple double-strand breaks within the genome, we developed a bio-safety switch that could potentially prevent the adverse effects of current and future cell therapies. Finally, I lay out the potential concerns and threats that such an advance in genome editing technology may be bringing and point out possible solutions to mitigate the risks
Valladares, Rodrigo, et Hanna Briheim. « Metoder och tillämpningar av CRISPR-Cas9 i cancerforskning. : Samt hur CRISPR-Cas9 kan implementeras i skolundervisningen ». Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166140.
Texte intégralCRISPR-Cas9 has recently emerged as an effective genome editing tool. The tool derives from an adaptive immune system in prokaryotes. The technology is used for modification of DNA in plants, animals and humans in a simple and inexpensive way. CRISPR-Cas9 has shown great potential in fighting different diseases like cancer which today is a global health issue. It is seen as a promising tool for cancer research when it comes to cancer therapy and drug development. Here we summarize current methods and applications of CRISPR-Cas9 for cancer research. Furthermore, we explore the possibilities of introducing and applying this kind of genetic engineering in biology teaching.
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Toffessi, Tcheuyap Vanina. « Development of von Willebrand Factor Zebrafish Mutant Using CRISPR/Cas9 Mediated Genome Editing ». Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc984227/.
Texte intégralCanver, Matthew. « Elucidation of Mechanisms of Fetal Hemoglobin Regulation by CRISPR/Cas9 Mediated Genome Editing ». Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:33493407.
Texte intégralMedical Sciences
Antoniani, Chiara. « A genome editing approach to induce fetal hemoglobin expression for the treatment of β-hemoglobinopathies ». Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB077.
Texte intégralΒ-hemoglobinopathies (β-thalassemias and sickle cell disease) are genetic anemias affecting thousands of newborns annually worldwide. β-thalassemias and sickle cell disease (SCD) are caused by mutations affecting the adult hemoglobin expression and are currently treated by red blood cell transfusion and iron chelation regiments. For patients affected by severe β-hemoglobinopathies, allogenic hematopoietic stem cell (HSCs) transplantation is the only definitive therapy. However, transplantation of autologous, genetically corrected HSCs represents an alternative therapy for patients lacking a suitable HSC donor. Naturally occurring large deletions encompassing β- and δ-globin genes in the β-globin gene cluster, defined as Hereditary Persistence of Fetal Hemoglobin (HPFH) traits, lead to increased fetal hemoglobin (HbF) expression ameliorating both thalassemic and SCD clinical phenotypes. In this study, we integrated transcription factor binding site analysis and HPFH genetic data to identify potential HbF silencers in the β-globin locus. Based on this analysis, we designed a CRISPR/Cas9 strategy disrupting: (i) a putative δγ-intergenic HbF silencer targeted by the HbF repressor BCL11A in adult erythroblasts; (ii) the shortest deletion associated with elevated HbF levels (“Corfu” deletion) in β-thalassemic patients, encompassing the putative δγ-intergenic HbF silencer; (iii) a 13.6-kb genomic region including the δ- and β-globin genes and the putative intergenic HbF silencer. Targeting the 13.6-kb region, but not the Corfu and the putative δγ-intergenic regions, caused a robust HbF re-activation and a concomitant reduction in β-globin expression in an adult erythroid cell line and in healthy donor hematopoietic stem/progenitor cells (HSPC)-derived erythroblasts. We provided a proof of principle of this potential therapeutic strategy: disruption of the 13.6-kb region in HSPCs from SCD donors favored the β-to-γ globin switching in a significant proportion of HSPC-derived erythroblasts, leading to the amelioration of the SCD cell phenotype. Finally, we dissected the mechanisms leading to HbF de-repression demonstrating changes in the chromatin conformation and epigenetic modifications within the β-globin locus upon deletion or inversion of the 13.6-kb region. Overall, this study contributes to the knowledge of the mechanisms underlying fetal to adult hemoglobin switching, and provides clues for a genome editing approach to the treatment of SCD and β-thalassemia
Lin, ChieYu. « Characterization and Optimization of the CRISPR/Cas System for Applications in Genome Engineering ». Thesis, Harvard University, 2014. http://etds.lib.harvard.edu/hms/admin/view/61.
Texte intégralHsu, Patrick David. « Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering ». Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13068392.
Texte intégralLivres sur le sujet "CRISPR, Cas9, genome editing, gRNA"
María Vaschetto, Luis. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases. New York : CRC Press, 2021. http://dx.doi.org/10.1201/9781003088516.
Texte intégralKozubek, James. Modern Prometheus : Editing the Human Genome with Crispr-Cas9. Cambridge University Press, 2016.
Trouver le texte intégralRavindhran, Ramalingam, Govindan Ganesan et Vinoth A. Crop Genome Editing Using CRISPR/Cas9 : Theory and Practice. Elsevier Science & Technology, 2019.
Trouver le texte intégralModern Prometheus : Editing the Human Genome with Crispr-Cas9. Cambridge University Press, 2018.
Trouver le texte intégralKozubek, Jim. Modern Prometheus : Editing the Human Genome with Crispr-Cas9. Cambridge University Press, 2018.
Trouver le texte intégralRavindhran, Ramalingam, Govindan Ganesan et Vinoth A. Crop Genome Editing Using CRISPR/Cas9 : Theory and Practice. Elsevier Science & Technology Books, 2019.
Trouver le texte intégralKozubek, James. Modern Prometheus : Editing the Human Genome with Crispr-Cas9. Cambridge University Press, 2019.
Trouver le texte intégralVaschetto, Luis María. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases. Taylor & Francis Group, 2021.
Trouver le texte intégralVaschetto, Luis M. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases. CRC Press LLC, 2022.
Trouver le texte intégralVaschetto, Luis M. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases. Taylor & Francis Group, 2022.
Trouver le texte intégralChapitres de livres sur le sujet "CRISPR, Cas9, genome editing, gRNA"
Hoof, Jakob B., Christina S. Nødvig et Uffe H. Mortensen. « Genome Editing : CRISPR-Cas9 ». Dans Methods in Molecular Biology, 119–32. New York, NY : Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7804-5_11.
Texte intégralSeruggia, Davide, et Lluis Montoliu. « CRISPR/Cas9 Approaches to Investigate the Noncoding Genome ». Dans Genome Editing, 31–43. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34148-4_2.
Texte intégralPatial, Meghna, Kiran Devi et Rohit Joshi. « CRISPR/Cas9-Mediated Targeted Mutagenesis in Medicinal Plants ». Dans Genome Editing, 55–70. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08072-2_3.
Texte intégralBansal, Monika, et Shabir Hussain Wani. « Virus-Mediated Delivery of CRISPR/CAS9 System in Plants ». Dans Genome Editing, 197–203. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08072-2_10.
Texte intégralGurumurthy, Channabasavaiah B., Rolen M. Quadros, Masahiro Sato, Tomoji Mashimo, K. C. Kent Lloyd et Masato Ohtsuka. « CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation Technologies ». Dans Genome Editing, 65–77. Cham : Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-34148-4_4.
Texte intégralKatam, Ramesh, Fatemeh Hasanvand, Vinson Teniyah, Jessi Noel et Virginia Gottschalk. « Biosafety Issue Related to Genome Editing in Plants Using CRISPR-Cas9 ». Dans Genome Editing, 289–317. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08072-2_16.
Texte intégralSaeed, Fozia, Tariq Shah, Sherien Bukhat, Fazal Munsif, Ijaz Ahmad, Hamad Khan et Aziz Khan. « Genome Engineering as a Tool for Enhancing Crop Traits : Lessons from CRISPR/Cas9 ». Dans Genome Editing, 3–25. Cham : Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08072-2_1.
Texte intégralNadakuduti, Satya Swathi, Colby G. Starker, Daniel F. Voytas, C. Robin Buell et David S. Douches. « Genome Editing in Potato with CRISPR/Cas9 ». Dans Methods in Molecular Biology, 183–201. New York, NY : Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-8991-1_14.
Texte intégralLiu, Junqi, Samatha Gunapati, Nicole T. Mihelich, Adrian O. Stec, Jean-Michel Michno et Robert M. Stupar. « Genome Editing in Soybean with CRISPR/Cas9 ». Dans Methods in Molecular Biology, 217–34. New York, NY : Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-8991-1_16.
Texte intégralVelusamy, Thilaga, Anjali Gowripalan et David C. Tscharke. « CRISPR/Cas9-Based Genome Editing of HSV ». Dans Methods in Molecular Biology, 169–83. New York, NY : Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9814-2_9.
Texte intégralActes de conférences sur le sujet "CRISPR, Cas9, genome editing, gRNA"
Shukla, Jayanti, Bhairvi Pant, Neema Tufchi, Gracy Chand Paul, Kumud Pant, Manu Pant et Somya Sihna. « CRISPR Cas9 genome editing approach for gRNA of the genes associated with Schizophrenia : A computational approach ». Dans 2022 2nd International Conference on Innovative Sustainable Computational Technologies (CISCT). IEEE, 2022. http://dx.doi.org/10.1109/cisct55310.2022.10046633.
Texte intégralStacey, Minviluz. « Utility of CRISPR/Cas in accelerating gene discovery in soybean ». Dans 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/rzne1660.
Texte intégralMETLEVA, Anastasia S., et Konstantin V. BESPOMESTNYKH. « Selection of Grna for Genomic Editing of the Bovine Leucosis Virus Susceptible Alleles of the 2 Exon of the Bola-DRB3 Gene by CRISPR/Cas9 ». Dans IV International Scientific and Practical Conference "Modern S&T Equipments and Problems in Agriculture". Sibac, 2020. http://dx.doi.org/10.32743/kuz.mepa.2020.148-157.
Texte intégralTedesco, Donato, Paul Diehl, Mikhail Makhanov, Sylvain Baron, Dmitry Suchkov et Alex Chenchik. « Abstract C161 : CRISPR/Cas9 genome-wide gRNA library screening platform ». Dans Abstracts : AACR-NCI-EORTC International Conference : Molecular Targets and Cancer Therapeutics ; November 5-9, 2015 ; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c161.
Texte intégralTedesco, Donato, Paul Diehl, Mikhail Makhanov, Sylvain Baron, Dmitry Suchkov, Costa Frangou et Alex Chenchik. « Abstract 4354 : CRISPR/Cas9 genome-wide gRNA library for target identification ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4354.
Texte intégralRastogi, Khushboo. « Rice Biofortification through CRISPR/Cas9-Multiplex Genome Editing ». Dans ASPB PLANT BIOLOGY 2020. USA : ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1383191.
Texte intégralShima, K., T. Suzuki, Y. Ma, C. Mayhew, A. Sallese, B. C. Carey, P. Arumugam et B. C. Trapnell. « CRISPR/Cas9 Genome Editing Therapy for Hereditary Pulmonary Alveolar Proteinosis ». Dans American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4004.
Texte intégralКершанская, О. И., Г. Л. Есенбаева, Д. С. Нелидова, З. Н. Садуллаева et С. Н. Нелидов. « PERSPECTIVES OF BREEDING DEVELOPMENT IN BARLEY THROUGH CRISPR/CAS9 GENOME EDITING ». Dans Материалы I Всероссийской научно-практической конференции с международным участием «Геномика и современные биотехнологии в размножении, селекции и сохранении растений». Crossref, 2020. http://dx.doi.org/10.47882/genbio.2020.48.47.015.
Texte intégralZheng, Qi, Ling-Jie Kong, Huanyu Jin, Jinling Li et Ruby Yanru Chen-Tsai. « Abstract 663 : Factors affecting genome editing using CRISPR/Cas9 in mouse model ». Dans Proceedings : AACR 107th Annual Meeting 2016 ; April 16-20, 2016 ; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-663.
Texte intégral« CRISPR/Cas9 – mediated genome editing of bread wheat to modulate heading time ». Dans Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Novosibirsk ICG SB RAS 2021, 2021. http://dx.doi.org/10.18699/plantgen2021-135.
Texte intégralRapports d'organisations sur le sujet "CRISPR, Cas9, genome editing, gRNA"
Paran, Ilan, et Allen Van Deynze. Regulation of pepper fruit color, chloroplasts development and their importance in fruit quality. United States Department of Agriculture, janvier 2014. http://dx.doi.org/10.32747/2014.7598173.bard.
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